Philip Reed Larsen

Possui graduação em Medicina pela Columbia University(1963), especialização em Research Fellow In Endocrinology pela National Institute Of Health(1967) e residencia-medicapela Columbia University(1965). Atualmente é professor titular da Harvard Medical School. Tem experiência na área de Medicina, com ênfase em Clínica Médica.

Informações coletadas do Lattes em 10/11/2022

Acadêmico

Formação acadêmica

Especialização - Residência médica

1963 - 1965

Columbia University
Residência médica em: Internal MedicineNúmero do registro: . Grande área: Ciências da Saúde / Área: Medicina / Subárea: Clínica Médica.

Especialização em Research Fellow In Endocrinology

1965 - 1967

National Institute Of Health
Orientador: J WOLFF

Graduação em Medicina

1959 - 1963

Columbia University

Idiomas

Bandeira representando o idioma Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Áreas de atuação

Grande área: Ciências da Saúde / Área: Medicina / Subárea: Clínica Médica/Especialidade: Endocrinologia.

Grande área: Ciências Biológicas / Área: Fisiologia / Subárea: Fisiologia de Órgãos e Sistemas/Especialidade: Fisiologia Endócrina.

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.

Produções bibliográficas

  • CANANI, Luis Henrique ; CAPP, Clarissa ; DORA, Jose Miguel ; MEYER, Erika L Souza ; WAGNER, Marcia S ; HARNEY, John W ; GROSS, Jorge Luiz ; LARSEN, Philip Reed ; BIANCO, Antonio C ; MAIA, Ana Luiza . The Type 2 Deiodinase A/G (Thr92Ala) Polymorphism is associated with Decreased Enzyme Velocity and Increased Insulin Resistance in Patients with Type 2 Diabetes Mellitus. Journal of Clinical Endocrinology and Metabolism , Estados Unidos, v. in, n.press, 2005.

  • ZAVACKI, A M ; YING, H ; CHRISTOFFOLETE, M A ; AERTS, G ; SO, e ; HARNEY, John W ; CHENG, Sy ; LARSEN, Philip Reed ; BIANCO, Antonio C . Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.. Endocrinology , Estados Unidos, v. 146, p. 1568-1575, 2005.

  • ALEXANDER, e K ; MARQUSEE, e ; FISCHER, G A ; LARSEN, Philip Reed ; LAWRENCE, J . Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism . New England Journal of Medicine , Estados Unidos, v. 351, p. 241-249, 2004.

  • KIM, S W ; HONG, S J ; KIM, K M ; SO, e ; HO, S C ; LARSEN, Philip Reed . A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene. Molecular Endocrinology , Estados Unidos, v. 12, p. 2924-2936, 2004.

  • CARVALHO-BIANCO, Suzy D ; KIM, Brian W ; ZHANG, J X ; RIBEIRO, Rogerio S ; GEREBEN, Balaz ; MENDE, U ; LARSEN, Philip Reed . Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.. Molecular Endocrinology , Estados Unidos, v. 18, p. 1840-1849, 2004.

  • FEKETE, C ; GEREBEN, Balaz ; DOLESCHALL, M ; HARNEY, John W ; DORA, Jose Miguel ; BIANCO, Antonio C ; SARKAR, S ; KACSKOVICS, I ; LARSEN, Philip Reed ; LECHAN, R M . Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology , Estados Unidos, v. 145, p. 1649-1655, 2004.

  • KIM, Brian W ; ZAVACKI, A M ; MORELLI, Cyntia Curcio ; DENTICE, Monica ; HARNEY, John W ; LARSEN, Philip Reed ; BIANCO, Antonio C . Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Molecular Endocrinology , Estados Unidos, v. 17, p. 2603-2612, 2003.

  • CALLEBAUT, I ; MORELLI, Cyntia Curcio ; MORNON, J P ; GEREBEN, Balaz ; BUETTNER, C ; HUANG, S ; CASTRO, B ; HARNEY, John W ; BIANCO, Antonio C ; LARSEN, Philip Reed . The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. Journal of Biological Chemistry , Estados Unidos, v. 278, p. 36887, 2003.

  • HUANG, S ; DORFMAN, D M ; SALVATORE, Domenico ; GENEST, D R ; LARSEN, Philip Reed . Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium.. Journal of Clinical Endocrinology and Metabolism , Estados Unidos, v. 88, p. 1384-1388, 2003.

  • KIM, Brian W ; DANIELS, G H ; HARRISON, B J ; PRICE, A ; LARSEN, Philip Reed ; WEETMAN, A P . Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels. Journal of Clinical Endocrinology and Metabolism , Estados Unidos, v. 88, p. 594-598, 2003.

  • MORELLI, Cyntia Curcio ; GEREBEN, Balaz ; ZAVACKI, A M ; KIM, Brian W ; HUANG, S ; HARNEY, John W ; BIANCO, Antonio C ; LARSEN, Philip Reed . In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology , Estados Unidos, v. 144, p. 937-946, 2003.

  • FRENCH, C. A. ; ALEXANDER, e K ; CIBAS, E. S. ; NOSE, V. ; LAGUETTE, J. ; FAQUIN, W. ; GARBER, J. ; MOORE, J. ; FLETCHER, J. A. ; LARSEN, Philip Reed . Genetic and biological subgroups of low-stage follicular thyroid cancer.. Am J Pathol, v. 162, p. 1053-1060, 2003.

  • ALEXANDER, e K ; HURWITZ, S. ; HEERING, J. P. ; BENSON, C. B. ; FRATES, M. C. ; DOUBILET, P. M. ; CIBAS, E. S. ; LARSEN, Philip Reed ; MARQUSEE, e . Natural history of benign solid and cystic thyroid nodules.. Ann Intern Med., v. 138, p. 315-318, 2003.

  • HUANG, S ; SALVATORE, Domenico ; MANDEL, Susan J ; DORFMAN, D M ; KOZAKEWICH, H P ; LARSEN, Philip Reed . A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase.. Journal of Clinical Endocrinology and Metabolism , Estados Unidos, v. 87, p. 4457-4451, 2002.

  • GEREBEN, Balaz ; KOLLAR, A ; HARNEY, John W ; LARSEN, Philip Reed . The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression. Molecular Endocrinology , Estados Unidos, v. 16, p. 1667-1679, 2002.

  • BIANCO, Antonio C ; SALVATORE, Domenico ; GEREBEN, Balaz ; BERRY, Marla J ; LARSEN, Philip Reed . Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.. Endocrine Reviews , Estados Unidos, v. 23, p. 38-89, 2002.

  • ALEXANDER, e K ; LARSEN, Philip Reed . High dose of (131)I therapy for the treatment of hyperthyroidism caused by Graves'disease. Journal of Clinical Endocrinology and Metabolism , Estados Unidos, v. 87, p. 1073-1077, 2002.

  • LARSEN, Philip Reed ; ROSS, J. E. ; TAPLEY, D. F. . Transport of neutral, dibasic and N-methyl substituted amino acids by rat small intestine.. Biochimica et Biophysica Acta, v. 88, p. 570-577, 1964.

Prêmios

2004

William Silen Lifetime Achievement in Mentoring Award, Harvard University.

2002

Edwin B. Astwood Lecture Award, Endocrine Society.

2000

Knoll Pharmaceuticals Mentor Award, The Endocrine Society.

1992

Merck Prize, European Thyroid Association.

1992

Clinical Endocrinology Trust of the United Kingdom: Medal for Distinguished Contributions to Endocrinology, Joint British Endocrine Societies.

1989

Parke-Davis Distinguished Lectureship, American Thyroid Association.

1987

Pitt-Rivers Lecturer, British Thyroid Club, Joint British Endocrine Societies.

1976

Van Meter-Armour Prize Award, American, American Thyroid Association.

Histórico profissional

Endereço profissional

  • Harvard Medical School, Brigham And Women's Hospital, Division Of Endocrinology Diabetes And Hypertension. , Room 644, Harvard Institutes of Medicine, 02115 - Boston, - Estados Unidos, URL da Homepage:

Experiência profissional

1975 - Atual

Harvard Medical School

Vínculo: Professor, Enquadramento Funcional: Professor titular, Carga horária: 0, Regime: Dedicação exclusiva.

Atividades

  • 01/2002

    Direção e administração, Brigham And Women's Hospital, Division Of Endocrinology Diabetes And Hypertension.,Cargo ou função, Chefe de Departamento.