Igor Correia de Almeida

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Produções bibliográficas

• FARANI, PRISCILA SILVA GRIJÓ ; BEGUM, KHODEZA ; VILAR-PEREIRA, GLAUCIA ; PEREIRA, ISABELA RESENDE ; ALMEIDA, IGOR C. ; ROY, SOURAV ; LANNES-VIEIRA, JOSELI ; MOREIRA, OTACILIO CRUZ . Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy. Frontiers in Cellular and Infection Microbiology , v. 11, p. 692655, 2021.

• ZAMITH-MIRANDA, DANIEL ; PERES DA SILVA, ROBERTA ; COUVILLION, SNEHA P. ; BREDEWEG, ERIN L. ; BURNET, MEAGAN C. ; COELHO, CAROLINA ; CAMACHO, EMMA ; NIMRICHTER, LEONARDO ; PUCCIA, ROSANA ; ALMEIDA, IGOR C. ; CASADEVALL, ARTURO ; RODRIGUES, MARCIO L. ; ALVES, LYSANGELA R. ; NOSANCHUK, JOSHUA D. ; NAKAYASU, ERNESTO S. . Omics Approaches for Understanding Biogenesis, Composition and Functions of Fungal Extracellular Vesicles. Frontiers in Genetics , v. 12, p. 648524, 2021.

• TORRICO, FAUSTINO GASCÓN, JOAQUIM BARREIRA, FABIANA BLUM, BETHANIA ALMEIDA, IGOR C ALONSO-VEGA, CRISTINA BARBOZA, TAYNÁ BILBE, GRAEME CORREIA, ERIKA GARCIA, WILSON ORTIZ, LOURDES PARRADO, RUDY RAMIREZ, JUAN CARLOS RIBEIRO, ISABELA STRUB-WOURGAFT, NATHALIE VAILLANT, MICHEL SOSA-ESTANI, SERGIO ARTEAGA, ROGER DE LA BARRA, ANABELLE CAMACHO BORJA, JHONNY MARTINEZ, IVANA FERNANDES, JAYME GARCIA, LINETH LOZANO, DANIEL PALACIOS, ALEJANDRO , et al. SCHIJMAN, ALEJANDRO PINAZO, MARIA JESUS PINTO, JIMMY ROJAS, GIMENA ESTEVAO, IGOR ORTEGA-RODRIGUEZ, URIEL MENDES, MARIA TAYS SCHUCK, EDGAR HATA, KATSURA MAKI, NORITSUGU ASADA, MAKOTO ; New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial. LANCET INFECTIOUS DISEASES , v. 21, p. 1129-1140, 2021.

• MONTOYA, ALBA L. ; AUSTIN, VICTORIA M. ; PORTILLO, SUSANA ; VINALES, IRODIEL ; ASHMUS, ROGER A. ; ESTEVAO, IGOR ; JANKURU, SOHAN R. ; ALRAEY, YASSER ; AL-SALEM, WALEED S. ; ACOSTA-SERRANO, ÁLVARO ; ALMEIDA, IGOR C. ; MICHAEL, KATJA . Reversed Immunoglycomics Identifies -Galactosyl-Bearing Glycotopes Specific for Infection. JACS Au , v. 1, p. 1275-1287, 2021.

• TODA, HARUKA DIAZ-VARELA, MIRIAM SEGUI-BARBER, JOAN ROOBSOONG, WANLAPA BARO, BARBARA GARCIA-SILVA, SUSANA GALIANO, ALICIA GUALDRÓN-LÓPEZ, MELISA ALMEIDA, ANNE C. G. BRITO, MARCELO A. M. DE MELO, GISELY CARDOSO APARICI-HERRAIZ, IRIS CASTRO-CAVADÍA, CARLOS MONTEIRO, WUELTON MARCELO BORRÀS, EVA SABIDÓ, EDUARD ALMEIDA, IGOR C. CHOJNACKI, JAKUB MARTINEZ-PICADO, JAVIER CALVO, MARIA ARMENGOL, PILAR CARMONA-FONSECA, JAIME YASNOT, MARIA FERNANDA LAUZURICA, RICARDO MARCILLA, ANTONIO , et al. PEINADO, HECTOR GALINSKI, MARY R. LACERDA, MARCUS V. G. SATTABONGKOT, JETSUMON FERNANDEZ-BECERRA, CARMEN DEL PORTILLO, HERNANDO A. ; Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence. Nature Communications , v. 11, p. 2761, 2020.

• CORTES-SERRA, NURIA ; MENDES, MARIA TAYS ; MAZAGATOS, CLARA ; SEGUI-BARBER, JOAN ; ELLIS, CAMERON C. ; BALLART, CRISTINA ; GARCIA-ALVAREZ, ANA ; GÁLLEGO, MONTSERRAT ; GASCON, JOAQUIM ; ALMEIDA, IGOR C. ; PINAZO, MARÍA JESÚS ; FERNANDEZ-BECERRA, CARMEN . Plasma-Derived Extracellular Vesicles as Potential Biomarkers in Heart Transplant Patient with Chronic Chagas Disease. EMERGING INFECTIOUS DISEASES , v. 26, p. 1846-1851, 2020.

• ALONSO-PADILLA, JULIO ; ABRIL, MARCELO ; ALARCÓN DE NOYA, BELKISYOLÉ ; ALMEIDA, IGOR C. ; ANGHEBEN, ANDREA ; ARAUJO JORGE, TANIA ; CHATELAIN, ERIC ; ESTEVA, MONICA ; GASCÓN, JOAQUIM ; GRIJALVA, MARIO J. ; GUHL, FELIPE ; HASSLOCHER-MORENO, ALEJANDRO MARCEL ; LÓPEZ, MANUEL CARLOS ; LUQUETTI, ALEJANDRO ; NOYA, OSCAR ; PINAZO, MARÍA JESÚS ; RAMSEY, JANINE M. ; RIBEIRO, ISABELA ; RUIZ, ANDRES MARIANO ; SCHIJMAN, ALEJANDRO G. ; SOSA-ESTANI, SERGIO ; THOMAS, M. CARMEN ; TORRICO, FAUSTINO ; ZREIN, MAAN ; PICADO, ALBERT . Target product profile for a test for the early assessment of treatment efficacy in Chagas disease patients: An expert consensus. PLoS Neglected Tropical Diseases , v. 14, p. e0008035, 2020.

• CRONEMBERGER-ANDRADE, ANDRÉ ; XANDER, PATRÍCIA ; SOARES, RODRIGO PEDRO ; PESSOA, NATÁLIA LIMA ; CAMPOS, MARCO ANTÔNIO ; ELLIS, CAMERON C. ; GRAJEDA, BRIAN ; OFIR-BIRIN, YIFAT ; ALMEIDA, IGOR CORREIA ; REGEV-RUDZKI, NETA ; TORRECILHAS, ANA CLAUDIA . Trypanosoma cruzi-Infected Human Macrophages Shed Proinflammatory Extracellular Vesicles That Enhance Host-Cell Invasion via Toll-Like Receptor 2. Frontiers in Cellular and Infection Microbiology , v. 10, p. 99, 2020.

• COSTA MENDONÇA-NATIVIDADE, FLÁVIA ; DUQUE LOPES, CARLA ; RICCI-AZEVEDO, RAFAEL ; SARDINHA-SILVA, ALINE ; FIGUEIREDO PINZAN, CAMILA ; PAIVA ALEGRE-MALLER, ANA CLAUDIA ; L. NOHARA, LILIAN ; B. CARNEIRO, ALAN ; PANUNTO-CASTELO, ADEMILSON ; C. ALMEIDA, IGOR ; ROQUE-BARREIRA, MARIA CRISTINA . Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from Toxoplasma Gondii. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 20, p. 5001, 2019.

• DUARTE, TREVOR T. ; ELLIS, CAMERON C. ; GRAJEDA, BRIAN I. ; DE CHATTERJEE, ATASI ; ALMEIDA, IGOR C. ; DAS, SIDDHARTHA . A Targeted Mass Spectrometric Analysis Reveals the Presence of a Reduced but Dynamic Sphingolipid Metabolic Pathway in an Ancient Protozoan, Giardia lamblia. Frontiers in Cellular and Infection Microbiology , v. 9, p. 245, 2019.

• PORTILLO, SUSANA ; ZEPEDA, BRENDA G. ; INIGUEZ, EVA ; OLIVAS, JANET J. ; KARIMI, NASIM H. ; MOREIRA, OTACILIO C. ; MARQUES, ALEXANDRE F. ; MICHAEL, KATJA ; MALDONADO, ROSA A. ; ALMEIDA, IGOR C. . A prophylactic -Gal-based glycovaccine effectively protects against murine acute Chagas disease. npj Vaccines , v. 4, p. 13, 2019.

• QASIM, HANAN ; KARIM, ZUBAIR A. ; SILVA'ESPINOZA, JUAN C. ; KHASAWNEH, FADI T. ; RIVERA, JOSÉ O. ; ELLIS, CAMERON C. ; BAUER, STEPHANIE L. ; ALMEIDA, IGOR C. ; ALSHBOOL, FATIMA Z. . Short-Term E-Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice. Journal of the American Heart Association , v. 7, p. e009264, 2018.

• RIBEIRO, KLEBER SILVA ; VASCONCELLOS, CAMILLA IOSHIDA ; SOARES, RODRIGO PEDRO ; MENDES, MARIA TAYS ; ELLIS, CAMERON C. ; AGUILERA-FLORES, MARCELA ; DE ALMEIDA, IGOR CORREIA ; SCHENKMAN, SERGIO ; IWAI, LEO KEI ; TORRECILHAS, ANA CLAUDIA . Proteomic analysis reveals different composition of extracellular vesicles released by two Trypanosoma cruzi strains associated with their distinct interaction with host cells. JOURNAL OF EXTRACELLULAR VESICLES , v. 7, p. 1463779, 2018.

• SUBRAMANIAM, KRISHANTHI S. ; AUSTIN, VICTORIA ; SCHOCKER, NATHANIEL S. ; MONTOYA, ALBA L. ; ANDERSON, MATTHEW S. ; ASHMUS, ROGER A. ; MESRI, MINA ; AL-SALEM, WALEED ; ALMEIDA, IGOR C. ; MICHAEL, KATJA ; ACOSTA-SERRANO, ALVARO . Anti--Gal antibodies detected by novel neoglycoproteins as a diagnostic tool for Old World cutaneous leishmaniasis caused by. PARASITOLOGY , v. 145, p. 1758-1764, 2018.

• TORRICO, FAUSTINO GASCON, JOAQUIM ORTIZ, LOURDES ALONSO-VEGA, CRISTINA PINAZO, MARÍA-JESÚS SCHIJMAN, ALEJANDRO ALMEIDA, IGOR C ALVES, FABIANA STRUB-WOURGAFT, NATHALIE RIBEIRO, ISABELA SANTINA, GLAUCIA BLUM, BETHANIA CORREIA, ERIKA GARCIA-BOURNISEN, FACUNDO VAILLANT, MICHEL MORALES, JIMENA RAMOS PINTO ROCHA, JIMY JOSE ROJAS DELGADILLO, GIMENA MAGNE ANZOLEAGA, HELMUT RAMON MENDOZA, NILCE QUECHOVER, ROXANA CHALLAPA CABALLERO, MARIA YURLY ESCOBAR LOZANO BELTRAN, DANIEL FRANZ ZALABAR, ALBERT MENDOZA ROJAS PANOZO, LIZETH , et al. PALACIOS LOPEZ, ALEJANDRO TORRICO TERCEROS, DUNIA FERNANDEZ GALVEZ, VIOLETA ALEJANDRA CARDOZO, LETTY CUELLAR, GABRIELA VASCO ARENAS, RUDY NELSON GONZALES, ISABEL HOYOS DELFIN, CARLOS FLORENCIO GARCIA, LINETH PARRADO, RUDY DE LA BARRA, ANABELLE MONTANO, NAIR VILLARROEL, SANDRO DUFFY, TOMAS BISIO, MARGARITA RAMIREZ, JUAN CARLOS DUNCANSON, FRED EVERSON, MICHAEL DANIELS, ANTONIA ASADA, MAKOTO COX, EUGENE WESCHE, DAVID DIDERICHSEN, PAUL MATTHIAS MARQUES, ALEXANDRE F IZQUIERDO, LUIS SENDER, SILVIA SANZ REVERTER, JOAN CARLOS MORALES, MANUEL JIMENEZ, WLADIMIRO ; Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial. LANCET INFECTIOUS DISEASES , v. 18, p. 419-430, 2018.

• INIGUEZ, EVA ; SCHOCKER, NATHANIEL S. ; SUBRAMANIAM, KRISHANTHI ; PORTILLO, SUSANA ; MONTOYA, ALBA L. ; AL-SALEM, WALEED S. ; TORRES, CARESSE L. ; RODRIGUEZ, FELIPE ; MOREIRA, OTACILIO C. ; ACOSTA-SERRANO, ALVARO ; MICHAEL, KATJA ; ALMEIDA, IGOR C. ; MALDONADO, ROSA A. . An -Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major. PLoS Neglected Tropical Diseases , v. 11, p. e0006039, 2017.

• SHARMA, AABHA I. ; OLSON, CHERYL L. ; MAMEDE, JOÃO I. ; GAZOS-LOPES, FELIPE ; EPTING, CONRAD L. ; ALMEIDA, IGOR C. ; ENGMAN, DAVID M. . Sterol targeting drugs reveal life cycle stage-specific differences in trypanosome lipid rafts. Scientific Reports , v. 7, p. 9105, 2017.

• ZHENG, XUEYUN ; ZHANG, XING ; SCHOCKER, NATHANIEL S. ; RENSLOW, RYAN S. ; ORTON, DANIEL J. ; KHAMSI, JAMAL ; ASHMUS, ROGER A. ; ALMEIDA, IGOR C. ; TANG, KEQI ; COSTELLO, CATHERINE E. ; SMITH, RICHARD D. ; MICHAEL, KATJA ; BAKER, ERIN S. . Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses. ANALYTICAL AND BIOANALYTICAL CHEMISTRY , v. 409, p. 467-476, 2017.

• PINAZO, MARIA-JESUS ; POSADA, ELIZABETH DE JESUS ; IZQUIERDO, LUIS ; TASSIES, DOLORS ; MARQUES, ALEXANDRE-FERREIRA ; DE LAZZARI, ELISA ; ALDASORO, EDELWEISS ; MUOZ, JOSE ; ABRAS, ALBA ; TEBAR, SILVIA ; GALLEGO, MONTSERRAT ; DE ALMEIDA, IGOR CORREIA ; REVERTER, JOAN-CARLES ; GASCON, JOAQUIM . Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response. PLoS Neglected Tropical Diseases (Online) , v. 10, p. e0004269, 2016.

• RAMIREZ, M.I. ; DEOLINDO, P. ; DE MESSIAS-REASON, I.J. ; ARIGI, EMMA A. ; CHOI, H. ; ALMEIDA, I.C. ; EVANS-OSSES, I. . Dynamic flux of microvesicles modulate parasite-host cell interaction of Trypanosoma cruzi in eukaryotic cells. CELLULAR MICROBIOLOGY , v. 19, p. e12672, 2016.

• BRITO, CARLOS RAMON NASCIMENTO ; MCKAY, CRAIG S. ; AZEVEDO, MAÍRA ARAÚJO ; SANTOS, LUÍZA COSTA BRANDÃO ; VENUTO, ANA PAULA ; NUNES, DANIELA FERREIRA ; D?ÁVILA, DANIELLA ALCHAAR ; RODRIGUES DA CUNHA, GISELE MACEDO ; ALMEIDA, IGOR CORREIA ; GAZZINELLI, RICARDO TOSTES ; GALVÃO, LUCIA MARIA CUNHA ; CHIARI, EGLER ; SANHUEZA, CARLOS A. ; FINN, M. G. ; MARQUES, ALEXANDRE FERREIRA . Virus-like Particle Display of the -Gal Epitope for the Diagnostic Assessment of Chagas Disease. ACS Infectious Diseases , v. 2, p. 917-922, 2016.

• SZEMPRUCH, ANTHONYJ. ; SYKES, STEVENE. ; KIEFT, RUDO ; DENNISON, LAUREN ; BECKER, ALLISONC. ; GARTRELL, ANZIO ; MARTIN, WILLIAMJ. ; NAKAYASU, ERNESTOS. ; ALMEIDA, IGORC. ; HAJDUK, STEPHENL. ; HARRINGTON, JOHNM. . Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia. CELL , v. 164, p. 246-257, 2016.

• HERRERA, LINDA J. ; BRAND, STEPHEN ; SANTOS, ANDRES ; NOHARA, LILIAN L. ; HARRISON, JUSTIN ; NORCROSS, NEIL R. ; THOMPSON, STEPHEN ; SMITH, VICTORIA ; LEMA, CAROLINA ; VARELA-RAMIREZ, ARMANDO ; GILBERT, IAN H. ; ALMEIDA, IGOR C. ; MALDONADO, ROSA A. . Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi. PLoS Neglected Tropical Diseases , v. 10, p. e0004540, 2016.

• ARAUJO, RICARDO NASCIMENTO ; FRANCO, PAULA FERREIRA ; RODRIGUES, HENRIQUE ; SANTOS, LUIZA C.B. ; MCKAY, CRAIG S. ; SANHUEZA, CARLOS A. ; BRITO, CARLOS RAMON NASCIMENTO ; AZEVEDO, MAÍRA ARAÚJO ; VENUTO, ANA PAULA ; COWAN, PETER J. ; ALMEIDA, IGOR C. ; FINN, M.G. ; MARQUES, ALEXANDRE F. . Amblyomma sculptum tick saliva: -Gal identification, antibody response and possible association with red meat allergy in Brazil. INTERNATIONAL JOURNAL FOR PARASITOLOGY , v. 46, p. 213-220, 2016.

• VARGAS, GABRIELE ; ROCHA, JULIANA D. B. ; OLIVEIRA, DEBORA LEITE ; ALBUQUERQUE, PRISCILA COSTA ; FRASES, SUSANA ; SANTOS, SUELEN S. ; NOSANCHUK, JOSHUA DANIEL ; GOMES, ANDRE MARCO OLIVEIRA ; MEDEIROS, LIA C. A. S. ; MIRANDA, KILDARE ; SOBREIRA, TIAGO J. P. ; NAKAYASU, ERNESTO S. ; ARIGI, EMMA A. ; CASADEVALL, ARTURO ; GUIMARAES, ALLAN J. ; RODRIGUES, MARCIO L. ; FREIRE-DE-LIMA, CELIO GERALDO ; ALMEIDA, IGOR C. ; NIMRICHTER, LEONARDO . Compositional and immunobiological analyses of extracellular vesicles released by C andida albicans. Cellular Microbiology (Print) , v. 17, p. 389-407, 2015.

• LONGO, LARISSA V. G. ; NAKAYASU, ERNESTO S. ; PIRES, JHON H. S. ; GAZOS-LOPES, FELIPE ; VALLEJO, MILENE C. ; SOBREIRA, TIAGO J. P. ; ALMEIDA, IGOR C. ; PUCCIA, ROSANA . Characterization of Lipids and Proteins Associated to the Cell Wall of the Acapsular Mutant Cryptococcus neoformans Cap 67. The Journal of Eukaryotic Microbiology , v. 62, p. n/a-n/a, 2015.

• PINAZO, MARIA-JESUS ; THOMAS, MARIA-CARMEN ; BUSTAMANTE, JUAN ; ALMEIDA, Igor Correia de ; LOPEZ, MANUEL-CARLOS ; GASCON, JOAQUIM . Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives. Memórias do Instituto Oswaldo Cruz (Impresso) , v. 110, p. 422-432, 2015.

• IRIBARREN, P. A. ; BERAZATEGUI, M. A. ; BAYONA, J. C. ; ALMEIDA, I. C. ; CAZZULO, J. J. ; ALVAREZ, V. E. . Different proteomic strategies to identify genuine Small Ubiquitin-like MOdifier targets and their modification sites in procyclic forms. Cellular Microbiology (Print) , v. 17, p. 1413-1422, 2015.

• JACQUEZ, PEDRO ; AVILA, GUSTAVO ; BOONE, KYLE ; ALTIYEV, AGAMYRAT ; PUSCHHOF, JENS ; SAUTER, ROLAND ; ARIGI, EMMA ; RUIZ, BLANCA ; PENG, XIULI ; ALMEIDA, IGOR ; SHERMAN, MICHAEL ; XIAO, CHUAN ; SUN, JIANJUN . The Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen Pore. Plos One , v. 10, p. e0130832, 2015.

• LARA, FLAVIO ALVES ; POHL, PAULA C. ; GANDARA, ANA CAROLINE ; FERREIRA, JESSICA DA SILVA ; NASCIMENTO-SILVA, MARIA CLARA ; BECHARA, GERVÁSIO HENRIQUE ; SORGINE, MARCOS H. F. ; ALMEIDA, IGOR C. ; VAZ, ITABAJARA DA SILVA ; OLIVEIRA, PEDRO L. . ATP Binding Cassette Transporter Mediates Both Heme and Pesticide Detoxification in Tick Midgut Cells. Plos One , v. 10, p. e0134779, 2015.

• MAJUMDAR, SANGHAMITRA ; ALMEIDA, IGOR C. ; ARIGI, EMMA A. ; CHOI, HYUNGWON ; VERBERKMOES, NATHAN C. ; TRUJILLO-REYES, JESICA ; FLORES-MARGEZ, JUAN P. ; WHITE, JASON C. ; PERALTA-VIDEA, JOSE R. ; GARDEA-TORRESDEY, JORGE L. . Environmental Effects of Nanoceria on Seed Production of Common Bean ( ): A Proteomic Analysis. Environmental Science & Technology , v. 49, p. 13283-13293, 2015.

• MARTINS, NADINI OLIVEIRA ; SOUZA, RENATA TORRES DE ; CORDERO, ESTEBAN MAURICIO ; MALDONADO, DANIELLE CORTEZ ; CORTEZ, CRISTIAN ; MARINI, MARJORIE MENDES ; FERREIRA, EDEN RAMALHO ; BAYER-SANTOS, ETHEL ; ALMEIDA, Igor Correia de ; YOSHIDA, NOBUKO ; SILVEIRA, JOSÉ FRANCO DA . Molecular Characterization of a Novel Family of Trypanosoma cruzi Surface Membrane Proteins (TcSMP) Involved in Mammalian Host Cell Invasion. PLoS Neglected Tropical Diseases (Online) , v. 9, p. e0004216, 2015.

• SCHOCKER, NATHANIEL S. ; PORTILLO, SUSANA ; BRITO, CARLOS R. N. ; MARQUES, ALEXANDRE F. ; ALMEIDA, IGOR C. ; MICHAEL, KATJA . Synthesis of Gal(1,3)Gal(1,4)GlcNAc-, Gal(1,4)GlcNAc-, and GlcNAc-containing neoglycoproteins and their immunological evaluation in the context of Chagas disease. Glycobiology (Oxford) , v. 26, p. cwv081, 2015.

• DE ALMEIDA, IGOR CORREIA . Lytic anti-alpha-galactosyl antibodies as reliable biomarkers for the follow-up of Chagas disease chemotherapy.. Revista Espaola de Salud Pública , v. 88, p. 9-16, 2014.

• BAYER-SANTOS, ETHEL ; LIMA, FÁBIO MITSUO ; RUIZ, JERONIMO CONCEIÇÃO ; ALMEIDA, IGOR C. ; DA SILVEIRA, JOSÉ FRANCO . Characterization of the small RNA content of Trypanosoma cruzi extracellular vesicles. Molecular and Biochemical Parasitology (Print) , v. 193, p. 71-74, 2014.

• SERNA, CARYLINDA ; LARA, JOSHUA A. ; RODRIGUES, SILAS P. ; MARQUES, ALEXANDRE F. ; ALMEIDA, IGOR C. ; MALDONADO, ROSA A. . A synthetic peptide from Trypanosoma cruzi mucin-like associated surface protein as candidate for a vaccine against Chagas disease. Vaccine (Guildford) , v. 32, p. 3525-3532, 2014.

• MARIANO, VANIA SAMMARTINO ; ZORZETTO-FERNANDES, ANDRE LUIZ ; DA SILVA, THIAGO APARECIDO ; RUAS, LUCIANA PEREIRA ; NOHARA, LILIAN L. ; DE ALMEIDA, IGOR CORREIA ; ROQUE-BARREIRA, MARIA CRISTINA . Recognition of TLR2 N-Glycans: Critical Role in ArtinM Immunomodulatory Activity. Plos One , v. 9, p. e98512, 2014.

• GAZOS-LOPES, FELIPE ; OLIVEIRA, MAURICIO M. ; HOELZ, LUCAS V. B. ; VIEIRA, DANIELLE P. ; MARQUES, ALEXANDRE F. ; NAKAYASU, ERNESTO S. ; GOMES, MARTA T. ; SALLOUM, NASIM G. ; PASCUTTI, PEDRO G. ; SOUTO-PADRÓN, THAÏS ; MONTEIRO, ROBSON Q. ; LOPES, ANGELA H. ; ALMEIDA, IGOR C. . Structural and Functional Analysis of a Platelet-Activating Lysophosphatidylcholine of Trypanosoma cruzi. PLoS Neglected Tropical Diseases (Online) , v. 8, p. e3077, 2014.

• AL-SALEM, WALEED S. ; FERREIRA, DANIELA M. ; DYER, NAOMI A. ; ALYAMANI, ESSAM J. ; BALGHONAIM, SALAH M. ; AL-MEHNA, AHMED Y. ; AL-ZUBIANY, SALEEM ; IBRAHIM, EL-KEIR ; AL SHAHRANI, ALI M. ; ALKHUAILED, HAMED ; ALDAHAN, MOHAMMED A. ; AL JARALLH, ABDULAZIZ M. ; ABDELHADY, SAMER S. ; AL-ZAHRANI, MOHAMMED H. ; ALMEIDA, IGOR C. ; ACOSTA-SERRANO, ALVARO . Detection of high levels of anti--galactosyl antibodies in sera of patients with Old World cutaneous leishmaniasis: a possible tool for diagnosis and biomarker for cure in an elimination setting. Parasitology (London. Print) , v. 141, p. 1898-1903, 2014.

• ALEGRE-MALLER, ANA CLAUDIA PAIVA ; MENDONÇA, FLÁVIA COSTA ; DA SILVA, THIAGO APARECIDO ; OLIVEIRA, ALINE FERREIRA ; FREITAS, MATEUS SILVEIRA ; HANNA, EBERT SEIXAS ; ALMEIDA, IGOR C. ; GAY, NICHOLAS J. ; ROQUE-BARREIRA, MARIA CRISTINA . Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs. PLoS Neglected Tropical Diseases (Online) , v. 8, p. e3317, 2014.

• MARCILLA, ANTONIO ; MARTIN-JAULAR, LORENA ; TRELIS, MARIA ; DE MENEZES-NETO, ARMANDO ; OSUNA, ANTONIO ; BERNAL, DOLORES ; FERNANDEZ-BECERRA, CARMEN ; ALMEIDA, IGOR C. ; DEL PORTILLO, HERNANDO A. . Extracellular vesicles in parasitic diseases. Journal of Extracellular Vesicles , v. 3, p. 25040, 2014.

• TAHIRI, FATIMA ; LI, YUNSEN ; HAWKE, DAVID ; GANIKO, LUCIANE ; ALMEIDA, IGOR ; LEVERY, STEVEN ; ZHOU, DAPENG . Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology. Journal of Carbohydrate Chemistry , v. 32, p. 44-67, 2013.

• LONGO, LARISSA V.G. ; NAKAYASU, ERNESTO S. ; MATSUO, ALISSON L. ; PERES DA SILVA, ROBERTA ; SOBREIRA, TIAGO J.P. ; VALLEJO, MILENE C. ; GANIKO, LUCIANE ; ALMEIDA, IGOR C. ; PUCCIA, ROSANA . Identification of human plasma proteins associated with the cell wall of the pathogenic fungus Paracoccidioides brasiliensis. FEMS Microbiology Letters , v. 341, p. 87-95, 2013.

• BAYER-SANTOS, ETHEL ; AGUILAR-BONAVIDES, CLEMENTE ; RODRIGUES, SILAS PESSINI ; CORDERO, ESTEBAN MAURÍCIO ; MARQUES, ALEXANDRE FERREIRA ; VARELA-RAMIREZ, ARMANDO ; CHOI, HYUNGWON ; YOSHIDA, NOBUKO ; DA SILVEIRA, JOSÉ FRANCO ; ALMEIDA, IGOR C. . Proteomic Analysis of Trypanosoma cruzi Secretome: Characterization of Two Populations of Extracellular Vesicles and Soluble Proteins. Journal of Proteome Research (Print) , v. 12, p. 883-897, 2013.

• PENG, BO ; HUANG, XUEYONG ; NAKAYASU, ERNESTO S. ; PETERSEN, JOHN R. ; QIU, SUIMIN ; ALMEIDA, IGOR C. ; ZHANG, JIAN-YING . Using Immunoproteomics to Identify Alpha-enolase as an Autoantigen in Liver Fibrosis. Journal of Proteome Research (Print) , v. 12, p. 1789-1796, 2013.

• LONGO, LARISSA V. G. ; NAKAYASU, ERNESTO S. ; GAZOS-LOPES, FELIPE ; VALLEJO, MILENE C. ; MATSUO, ALISSON L. ; ALMEIDA, IGOR C. ; PUCCIA, ROSANA . Characterization of Cell Wall Lipids from the Pathogenic Phase of Paracoccidioides brasiliensis Cultivated in the Presence or Absence of Human Plasma. Plos One , v. 8, p. e63372, 2013.

• MENDEZ, T. L. ; DE CHATTERJEE, A. ; DUARTE, T. T. ; GAZOS-LOPES, F. ; ROBLES-MARTINEZ, L. ; ROY, D. ; SUN, J. ; MALDONADO, R. A. ; ROYCHOWDHURY, S. ; ALMEIDA, I. C. ; DAS, S. . Glucosylceramide Transferase Activity Is Critical for Encystation and Viable Cyst Production by an Intestinal Protozoan, Giardia lamblia. The Journal of Biological Chemistry (Print) , v. 288, p. 16747-16760, 2013.

• ASHMUS, ROGER A. ; SCHOCKER, NATHANIEL S. ; CORDERO-MENDOZA, YANIRA ; MARQUES, ALEXANDRE F. ; MONROY, ERIKA Y. ; PARDO, ANDREW ; IZQUIERDO, LUIS ; GÁLLEGO, MONSERRAT ; GASCON, JOAQUIM ; ALMEIDA, IGOR C. ; MICHAEL, KATJA . Potential use of synthetic alpha-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease. Organic & Biomolecular Chemistry , v. 11, p. 5579-5583, 2013.

• IZQUIERDO, LUIS ; MARQUES, ALEXANDRE FERREIRA ; GALLEGO, MONTSERRAT ; SANZ, SILVIA ; TEBAR, SILVIA ; RIERA, CRISTINA ; QUINTO, LLORENC ; ALDASORO, EDELWEISS ; ALMEIDA, IGOR C ; GASCON, JOAQUIM . Evaluation of a chemiluminescent enzyme-linked immunosorbent assay for the diagnosis of Trypanosoma cruzi infection in a nonendemic setting. Memórias do Instituto Oswaldo Cruz (Impresso) , v. 108, p. 928-931, 2013.

• CARNEIRO, ALAN BRITO ; IACIURA, BRUNA MARIA FERREIRA ; NOHARA, LILIAN LIE ; LOPES, CARLA DUQUE ; VEAS, ESTEBAN MAURICIO CORDERO ; MARIANO, VANIA SAMMARTINO ; BOZZA, PATRICIA TORRES ; LOPES, ULISSES GAZOS ; ATELLA, GEORGIA CORREA ; ALMEIDA, IGOR CORREIA ; SILVA-NETO, MÁRIO ALBERTO CARDOSO . Lysophosphatidylcholine Triggers TLR2- and TLR4-Mediated Signaling Pathways but Counteracts LPS-Induced NO Synthesis in Peritoneal Macrophages by Inhibiting NF-B Translocation and MAPK/ERK Phosphorylation. Plos One , v. 8, p. e76233, 2013.

• ZANFORLIN, TAMIRIS ; BAYER-SANTOS, ETHEL ; CORTEZ, CRISTIAN ; ALMEIDA, IGOR C. ; YOSHIDA, NOBUKO ; DA SILVEIRA, JOSÉ FRANCO . Molecular Characterization of Trypanosoma cruzi SAP Proteins with Host-Cell Lysosome Exocytosis-Inducing Activity Required for Parasite Invasion. Plos One , v. 8, p. e83864, 2013.

• RODRIGUES, MARCIO L. ; NAKAYASU, ERNESTO S. ; ALMEIDA, IGOR C. ; NIMRICHTER, LEONARDO . The impact of proteomics on the understanding of functions and biogenesis of fungal extracellular vesicles. Journal of Proteomics (Print) , v. Epub, p. April 10---, 2013.

• RIZZO, J. ; OLIVEIRA, D. L. ; JOFFE, L. S. ; HU, G. ; GAZOS-LOPES, F. ; FONSECA, F. L. ; ALMEIDA, I. C. ; FRASES, S. ; KRONSTAD, J. W. ; RODRIGUES, M. L. . Role of the Apt1 protein in polysaccharide secretion by Cryptococcus neoformans. Eukaryotic Cell , v. 13, p. 715-726, 2013.

• EAVES-PYLES, T. ; PATEL, J. ; ARIGI, E. ; CONG, Y. ; CAO, A. ; GARG, N. ; DHIMAN, M. ; PYLES, R. B. ; ARULANANDAM, B. ; MILLER, A. L. ; POPOV, V. L. ; SOONG, L. ; CARLSEN, E. D. ; COLETTA, C. ; SZABO, C. ; DE ALMEIDA, IGOR CORREIA . Immunomodulatory and antibacterial effects of cystatin 9 against Francisella tularensis.. Molecular Medicine (Cambridge, Mass. Print) , v. 19, p. 263-275, 2013.

• NAKAYASU, ERNESTO S. ; SOBREIRA, TIAGO J. P. ; TORRES, RAFAEL ; GANIKO, LUCIANE ; OLIVEIRA, PAULO S. L. ; MARQUES, ALEXANDRE F. ; ALMEIDA, IGOR C. . Improved Proteomic Approach for the Discovery of Potential Vaccine Targets in. Journal of Proteome Research (Print) , v. 11, p. 237-246, 2012.

• VALLEJO, MILENE C. ; NAKAYASU, ERNESTO S. ; MATSUO, ALISSON L. ; SOBREIRA, TIAGO J. P. ; LONGO, LARISSA V. G. ; GANIKO, LUCIANE ; ALMEIDA, IGOR C. ; PUCCIA, ROSANA . Vesicle and Vesicle-Free Extracellular Proteome of Paracoccidioides brasiliensis : Comparative Analysis with Other Pathogenic Fungi. Journal of Proteome Research (Print) , v. 11, p. 1676-1685, 2012.

• RODRIGUES, SILAS P. ; VENTURA, JOSÉ A. ; AGUILAR, CLEMENTE ; NAKAYASU, ERNESTO S. ; CHOI, HYUNGWON ; SOBREIRA, TIAGO J.P. ; NOHARA, LILIAN L. ; WERMELINGER, LUCIANA S. ; ALMEIDA, IGOR C. ; ZINGALI, RUSSOLINA B. ; FERNANDES, PATRICIA M.B. . Label-free quantitative proteomics reveals differentially regulated proteins in the latex of sticky diseased Carica papaya L. plants. Journal of Proteomics (Print) , v. 75, p. 3191-3198, 2012.

• Soares, R. P. ; Torrecilhas, A. C. ; ASSIS, R. R. ; ROCHA, M. N. ; MOURA E CASTRO, F. A. ; FREITAS, G. F. ; MURTA, S. M. ; SANTOS, S. L. ; MARQUES, A. F. ; ALMEIDA, I. C. ; ROMANHA, A. J. . Intraspecies Variation in Trypanosoma cruzi GPI-Mucins: Biological Activities and Differential Expression of -Galactosyl Residues. The American Journal of Tropical Medicine and Hygiene , v. 87, p. 87-96, 2012.

• VALLEJO, MILENE C. ; NAKAYASU, ERNESTO S. ; LONGO, LARISSA V. G. ; GANIKO, LUCIANE ; LOPES, FELIPE G. ; MATSUO, ALISSON L. ; ALMEIDA, IGOR C. ; PUCCIA, ROSANA . Lipidomic Analysis of Extracellular Vesicles from the Pathogenic Phase of Paracoccidioides brasiliensis. Plos One , v. 7, p. e39463, 2012.

• LOURES, FLÁVIO V. ; STROEDER, HELENI ; ALMEIDA, IGOR ; CALICH, VERA L. G. . Paracoccidioides brasiliensis lipids modulate macrophage activity via Toll-dependent or independent mechanisms. FEMS Immunology and Medical Microbiology (Print) , v. 66, p. 58-70, 2012.

• SONG, W. ; DELYRIA, E. S. ; CHEN, J. ; HUANG, W. ; LEE, J. S. ; MITTENDORF, E. A. ; IBRAHIM, N. ; RADVANYI, L. G. ; LI, Y. ; LU, H. ; XU, H. ; SHI, Y. ; WANG, L. ; ROSS, J. A. ; RODRIGUES, S. P. ; DE ALMEIDA, IGOR CORREIA ; YANG, X. ; QU, J. ; SCHOCKER, N. S. ; MICHAEL, K. ; ZHOU, D. . MUC1 glycopeptide epitopes predicted by computational glycomics. International Journal of Oncology , v. 41, p. 1977-1984, 2012.

• EMMER, B. T. ; NAKAYASU, E. S. ; SOUTHER, C. ; CHOI, H. ; SOBREIRA, T. J. P. ; EPTING, C. L. ; NESVIZHSKII, A. I. ; ALMEIDA, I. C. ; ENGMAN, D. M. . Global Analysis of Protein Palmitoylation in African Trypanosomes. Eukaryotic Cell , v. 10, p. 455-463, 2011.

• VALLEJO, M. C. ; MATSUO, A. L. ; GANIKO, L. ; MEDEIROS, L. C. S. ; MIRANDA, K. ; SILVA, L. S. ; FREYMULLER-HAAPALAINEN, E. ; SINIGAGLIA-COIMBRA, R. ; ALMEIDA, I. C. ; PUCCIA, R. . The Pathogenic Fungus Paracoccidioides brasiliensis Exports Extracellular Vesicles Containing Highly Immunogenic -Galactosyl Epitopes. Eukaryotic Cell , v. 10, p. 343-351, 2011.

• GUIMARÃES, ALLAN JEFFERSON ; NAKAYASU, ERNESTO S. ; SOBREIRA, TIAGO J. P. ; CORDERO, RADAMES J. B. ; NIMRICHTER, LEONARDO ; ALMEIDA, IGOR C. ; NOSANCHUK, JOSHUA DANIEL . Histoplasma capsulatum Heat-Shock 60 Orchestrates the Adaptation of the Fungus to Temperature Stress. Plos One , v. 6, p. e14660, 2011.

• BUSSACOS, ANA C.M. ; NAKAYASU, ERNESTO S. ; HECHT, MARIANA M. ; ASSUMPÇÃO, TERESA C.F. ; PARENTE, JULIANA A. ; SOARES, CÉLIA M.A. ; SANTANA, JAIME M. ; ALMEIDA, IGOR C. ; TEIXEIRA, ANTÔNIO R.L. . Redundancy of proteins in the salivary glands of Panstrongylus megistus secures prolonged procurement for blood meals. Journal of Proteomics (Print) , v. 74, p. 1693-1700, 2011.

• ZHOU, D. ; LEVERY, S. B. ; HSU, F. ; WANG, P. G. ; TENEBERG, S. ; ALMEIDA, I. C. ; LI, Y. ; XU, H. ; WANG, L. ; XIA, C. ; IBRAHIM, N. K. ; MICHAEL, K. . Immunologic mapping of glycomes: implications for cancer diagnosis and therapy.. Frontiers in Bioscience , v. 3, p. 1520, 2011.

• GENOVESIO, AUGUSTE ; GIARDINI, MIRIAM A. ; KWON, YONG-JUN ; DOSSIN, FERNANDO DE MACEDO ; CHOI, SEO YEON ; KIM, NAM YOUL ; KIM, HI CHUL ; JUNG, SUNG YONG ; SCHENKMAN, SERGIO ; ALMEIDA, IGOR C. ; EMANS, NEIL ; FREITAS-JUNIOR, LUCIO H. . Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection. Plos One , v. 6, p. e19733, 2011.

• RODRIGUES, SILAS P. ; VENTURA, JOSÉ A. ; AGUILAR, CLEMENTE ; NAKAYASU, ERNESTO S. ; ALMEIDA, IGOR C. ; FERNANDES, PATRICIA M. B. ; ZINGALI, RUSSOLINA B. . Proteomic analysis of papaya (Carica papaya L.) displaying typical sticky disease symptoms. Proteomics (Weinheim. Print) , v. 11, p. 2592-2602, 2011.

• BUSSACOS, ANA C.M. ; NAKAYASU, ERNESTO S. ; HECHT, MARIANA M. ; PARENTE, JULIANA A. ; SOARES, CÉLIA M.A. ; TEIXEIRA, ANTÔNIO R.L. ; ALMEIDA, IGOR C. . Diversity of anti-haemostatic proteins in the salivary glands of Rhodnius species transmitters of Chagas disease in the greater Amazon. Journal of Proteomics (Print) , v. 74, p. 1664-1672, 2011.

• PEREIRA, MIRIA G. ; NAKAYASU, ERNESTO S. ; SANT'ANNA, CELSO ; DE CICCO, NUCCIA N. T. ; ATELLA, GEORGIA C. ; DE SOUZA, WANDERLEY ; ALMEIDA, IGOR C. ; CUNHA-E-SILVA, NARCISA . Trypanosoma cruzi Epimastigotes Are Able to Store and Mobilize High Amounts of Cholesterol in Reservosome Lipid Inclusions. Plos One , v. 6, p. e22359, 2011.

• BAYONA, J. C. ; NAKAYASU, E. S. ; LAVERRIERE, M. ; AGUILAR, C. ; SOBREIRA, T. J. P. ; CHOI, H. ; NESVIZHSKII, A. I. ; ALMEIDA, I. C. ; CAZZULO, J. J. ; ALVAREZ, V. E. . SUMOylation Pathway in Trypanosoma cruzi: Functional Characterization and Proteomic Analysis of Target Proteins. Molecular & Cellular Proteomics , v. 10, p. M110.007369-M110.007369, 2011.

• GESTEIRA, TARSIS F. ; COULSON-THOMAS, VIVIEN JANE ; OGATA, FERNANDO T. ; FARIAS, EDUARDO H.C. ; CAVALHEIRO, RENAN P. ; DE LIMA, MARCELO A. ; CUNHA, GABRIEL L.A. ; NAKAYASU, ERNESTO S. ; ALMEIDA, IGOR C. ; TOMA, LENY ; NADER, HELENA B. . A novel approach for the characterisation of proteoglycans and biosynthetic enzymes in a snail model. Biochimica et Biophysica Acta. Proteins and Proteomics , v. 1814, p. 1862-1869, 2011.

• DE MARCHI, C. R. ; DI NOIA, J. M. ; FRASCH, A. C. C. ; AMATO NETO, V. ; ALMEIDA, I. C. ; BUSCAGLIA, C. A. . Evaluation of a Recombinant Trypanosoma cruzi Mucin-Like Antigen for Serodiagnosis of Chagas' Disease. Clinical and Vaccine Immunology , v. 18, p. 1850-1855, 2011.

• MARTIN-JAULAR, LORENA ; NAKAYASU, ERNESTO S. ; FERRER, MIREIA ; ALMEIDA, IGOR C. ; DEL PORTILLO, HERNANDO A. . Exosomes from Plasmodium yoelii-Infected Reticulocytes Protect Mice from Lethal Infections. Plos One , v. 6, p. e26588, 2011.

• MARQUES, ALEXANDRE ; NAKAYASU, ERNESTO ; ALMEIDA, IGOR . Purification of extracellular and intracellular amastigotes of Trypanosoma cruzi from mammalian host-infected cells. Nature Protocol Exchange , v. xx, p. xx-xx, 2011.

• VENKATAKRISHNAN, PRIYA ; NAKAYASU, ERNESTO S. ; ALMEIDA, IGOR C. ; MILLER, R.T. . Arginase activity in mitochondria - An interfering factor in nitric oxide synthase activity assays. Biochemical and Biophysical Research Communications (Print) , v. 394, p. 448-452, 2010.

• DOBROFF, ANDREY S. ; RODRIGUES, ELAINE G. ; JULIANO, MARIA A. ; FRIAÇA, DAYSON M. ; NAKAYASU, ERNESTO S. ; ALMEIDA, IGOR C. ; MORTARA, RENATO A. ; JACYSYN, JACQUELINE F. ; AMARANTE-MENDES, GUSTAVO P. ; MAGLIANI, WALTER ; CONTI, STEFANIA ; POLONELLI, LUCIANO ; TRAVASSOS, LUIZ R. . Differential Antitumor Effects of IgG and IgM Monoclonal Antibodies and Their Synthetic Complementarity-Determining Regions Directed to New Targets of B16F10-Nex2 Melanoma Cells. Translational Oncology (Online) , v. 3, p. 204-217, 2010.

• FONSECA, F. L. ; NOHARA, L. L. ; CORDERO, R. J. B. ; FRASES, S. ; CASADEVALL, A. ; ALMEIDA, I. C. ; NIMRICHTER, L. ; RODRIGUES, M. L. . Immunomodulatory Effects of Serotype B Glucuronoxylomannan from Cryptococcus gattii Correlate with Polysaccharide Diameter. Infection and Immunity (Print) , v. 78, p. 3861-3870, 2010.

• OLIVEIRA, DÉBORA L. ; NAKAYASU, ERNESTO S. ; JOFFE, LUNA S. ; GUIMARÃES, ALLAN J. ; SOBREIRA, TIAGO J. P. ; NOSANCHUK, JOSHUA D. ; CORDERO, RADAMES J. B. ; FRASES, SUSANA ; CASADEVALL, ARTURO ; ALMEIDA, IGOR C. ; NIMRICHTER, LEONARDO ; RODRIGUES, MARCIO L. . Characterization of Yeast Extracellular Vesicles: Evidence for the Participation of Different Pathways of Cellular Traffic in Vesicle Biogenesis. Plos One , v. 5, p. e11113, 2010.

• CRUZ, CARLOS E ; FOGAÇA, ANDRÉA C ; NAKAYASU, ERNESTO S ; ANGELI, CLÁUDIA B ; BELMONTE, RODRIGO ; ALMEIDA, IGOR C ; MIRANDA, ANTÔNIO ; MIRANDA, MARIA ; TANAKA, APARECIDA S ; BRAZ, GLÓRIA R ; CRAIK, CHARLES S ; SCHNEIDER, ERIC ; CAFFREY, CONOR R ; DAFFRE, SIRLEI . Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasites & Vectors , v. 3, p. 63, 2010.

• NOHARA, L.L. ; LEMA, C. ; BADER, J.O. ; AGUILERA, R.J. ; ALMEIDA, I.C. . High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi. Parasitology International (Print) , v. 59, p. 565-570, 2010.

• OLIVEIRA, DÉBORA L. ; NAKAYASU, ERNESTO S. ; JOFFE, LUNA S. ; GUIMARÃES, ALLAN J. ; SOBREIRA, TIAGO J. P. ; NOSANCHUK, JOSHUA D. ; CORDERO, RADAMES J. B. ; FRASES, SUSANA ; CASADEVALL, ARTURO ; ALMEIDA, IGOR C. ; NIMRICHTER, LEONARDO ; RODRIGUES, MARCIO L. . Biogenesis of extracellular vesicles in yeast: Many questions with few answers. Communicative & Integrative Biology , v. 3, p. 533-535, 2010.

• C. ALMEIDA, IGOR . Subcellular Proteomics and Global Analysis of Posttranslational Modifications to Study Functional Roles of Trypanosoma cruzi Molecules. The Open Parasitology Journal , v. 4, p. 167-177, 2010.

• MEDEIROS, MARCELO NEVES DE ; BELMONTE, RODRIGO ; SOARES, BRUNO CÉSAR C. ; MEDEIROS, LUCIANO NEVES DE ; CANETTI, CLÁUDIO ; FREIRE-DE-LIMA, CELIO G. ; MAYA-MONTEIRO, CLARISSA MENEZES ; BOZZA, PATRÍCIA TORRES ; ALMEIDA, IGOR C. ; MASUDA, HATISABURO ; KURTENBACH, ELEONORA ; MACHADO, EDNILDO A. . Arrest of oogenesis in the bug Rhodnius prolixus challenged with the fungus Aspergillus niger is mediated by immune response-derived PGE2. Journal of Insect Physiology , v. 55, p. 151-158, 2009.

• SANT'ANNA, CELSO ; NAKAYASU, ERNESTO S. ; PEREIRA, MIRIA G. ; LOURENÇO, DANIELA ; DE SOUZA, WANDERLEY ; ALMEIDA, IGOR C. ; CUNHA-E-SILVA, NARCISA L. . Subcellular proteomics of Trypanosoma cruzi reservosomes. Proteomics (Weinheim. Print) , v. 9, p. 1782-1794, 2009.

• NAKAYASU, ERNESTO S ; YASHUNSKY, DMITRY V ; NOHARA, LILIAN L ; TORRECILHAS, ANA CLAUDIA T ; NIKOLAEV, ANDREI V ; ALMEIDA, IGOR C . GPIomics: global analysis of glycosylphosphatidylinositol-anchored molecules of Trypanosoma cruzi. Molecular Systems Biology , v. 5, p. 261, 2009.

• VENKATAKRISHNAN, P. ; NAKAYASU, E. S. ; ALMEIDA, I. C. ; MILLER, R. T. . Absence of Nitric-oxide Synthase in Sequentially Purified Rat Liver Mitochondria. The Journal of Biological Chemistry (Print) , v. 284, p. 19843-19855, 2009.

• CORDERO, ESTEBAN M. ; NAKAYASU, ERNESTO S. ; GENTIL, LUCIANA G. ; YOSHIDA, NOBUKO ; ALMEIDA, IGOR C. ; DA SILVEIRA, JOSE' FRANCO . Proteomic Analysis of Detergent-Solubilized Membrane Proteins from Insect-Developmental Forms of Trypanosoma cruzi -. Journal of Proteome Research (Print) , v. 8, p. 3642-3652, 2009.

• NAKAYASU, ERNESTO S. ; GAYNOR, MATTHEW R. ; SOBREIRA, TIAGO J. P. ; ROSS, JEREMY A. ; ALMEIDA, IGOR C. . Phosphoproteomic analysis of the human pathogen Trypanosoma cruzi at the epimastigote stage. Proteomics (Weinheim. Print) , v. 9, p. 3489-3506, 2009.

• YICHOY, MAYTE ; NAKAYASU, ERNESTO S. ; SHPAK, MAX ; AGUILAR, CLEMENTE ; ALEY, STEPHEN B. ; ALMEIDA, IGOR C. ; DAS, SIDDHARTHA . Lipidomic analysis reveals that phosphatidylglycerol and phosphatidylethanolamine are newly generated phospholipids in an early-divergent protozoan, Giardia lamblia. Molecular and Biochemical Parasitology (Print) , v. 165, p. 67-78, 2009.

• DIAS, BIANCA R ; RODRIGUES, ELAINE G ; NIMRICHTER, LEONARDO ; NAKAYASU, ERNESTO S ; ALMEIDA, IGOR C ; TRAVASSOS, LUIZ R . Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3. Molecular Cancer , v. 8, p. 116, 2009.

• RODRIGUES, M. L. ; NAKAYASU, E. S. ; OLIVEIRA, D. L. ; NIMRICHTER, L. ; NOSANCHUK, J. D. ; ALMEIDA, I. C. ; CASADEVALL, A. . Extracellular Vesicles Produced by Cryptococcus neoformans Contain Protein Components Associated with Virulence. Eukaryotic Cell , v. 7, p. 58-67, 2008.

• FURUCHÓ, CELIA REGINA ; UMEZAWA, EUFROZINA S. ; ALMEIDA, IGOR ; FREITAS, VERA L. ; BEZERRA, RITA ; NUNES, ELISABETE V. ; SANCHES, MARIA C. ; GUASTINI, CRISTINA M. ; TEIXEIRA, ANTONIO R. ; SHIKANAI-YASUDA, MARIA A. . Inconclusive results in conventional serological screening for Chagas? disease in blood banks: evaluation of cellular and humoral response. TM & IH. Tropical Medicine and International Health (Print) , v. 13, p. 1527-1533, 2008.

• FRIDBERG, A. ; OLSON, C. L. ; NAKAYASU, E. S. ; TYLER, K. M. ; ALMEIDA, I. C. ; ENGMAN, D. M. . Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei. Journal of Cell Science , v. 121, p. 522-535, 2008.

• ALBUQUERQUE, PRISCILA COSTA ; NAKAYASU, ERNESTO S. ; RODRIGUES, MARCIO L. ; FRASES, SUSANA ; CASADEVALL, ARTURO ; ZANCOPE-OLIVEIRA, ROSELY M. ; ALMEIDA, IGOR C. ; NOSANCHUK, JOSHUA D. . Vesicular transport in Histoplasma capsulatum : an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes. Cellular Microbiology (Print) , v. 10, p. 1695-1710, 2008.

• LOOI, KOK SUN ; NAKAYASU, ERNESTO S. ; DIAZ, RAQUEL A. DE ; TAN, ENG M. ; ALMEIDA, IGOR C. ; ZHANG, JIAN-YING . Using Proteomic Approach to Identify Tumor-Associated Antigens as Markers in Hepatocellular Carcinoma. Journal of Proteome Research (Print) , v. 7, p. 4004-4012, 2008.

• DHIMAN, MONISHA ; NAKAYASU, ERNESTO SATOSHI ; MADAIAH, YASHODA HOSAKOTE ; REYNOLDS, BROBEY K. ; WEN, JIAN-JUN ; ALMEIDA, IGOR CORREIA ; GARG, NISHA JAIN . Enhanced Nitrosative Stress during Trypanosoma cruzi Infection Causes Nitrotyrosine Modification of Host Proteins. The American Journal of Pathology (Print) , v. 173, p. 728-740, 2008.

• MESQUITA, R. D. ; CARNEIRO, A. B. ; BAFICA, A. ; GAZOS-LOPES, F. ; TAKIYA, C. M. ; Souto-Padron, T. ; VIEIRA, D. P. ; FERREIRA-PEREIRA, A. ; ALMEIDA, I. C. ; FIGUEIREDO, R. T. ; PORTO, B. N. ; BOZZA, M. T. ; GRACA-SOUZA, A. V. ; LOPES, A. H. C. S. ; ATELLA, G. C. ; SILVA-NETO, M. A. C. . Trypanosoma cruzi Infection Is Enhanced by Vector Saliva through Immunosuppressant Mechanisms Mediated by Lysophosphatidylcholine. Infection and Immunity (Print) , v. 76, p. 5543-5552, 2008.

• PEREIRA, LOURIVALDO S. ; SILVA, PEDRO I. ; MIRANDA, M. TERÊSA M. ; ALMEIDA, IGOR C. ; NAOKI, HIDEO ; KONNO, KATSUHIRO ; DAFFRE, SIRLEI . Structural and biological characterization of one antibacterial acylpolyamine isolated from the hemocytes of the spider Acanthocurria gomesiana. Biochemical and Biophysical Research Communications (Print) , v. 352, p. 953-959, 2007.

• NOGUEIRA, NADIR F.S. ; GONZALEZ, MARCELO S. ; GOMES, JOSÉ EUGÊNIO ; DE SOUZA, WANDERLEY ; GARCIA, ELOI S. ; AZAMBUJA, PATRICIA ; NOHARA, LILIAN L. ; ALMEIDA, IGOR C. ; ZINGALES, BIANCA ; COLLI, WALTER . Trypanosoma cruzi: Involvement of glycoinositolphospholipids in the attachment to the luminal midgut surface of Rhodnius prolixus. Experimental Parasitology , v. 116, p. 120-128, 2007.

• MATSUO, ALISSON L. ; CARMONA, ADRIANA K. ; SILVA, LUIZ S. ; CUNHA, CARLOS E.L. ; NAKAYASU, ERNESTO S. ; ALMEIDA, IGOR C. ; JULIANO, MARIA A. ; PUCCIA, ROSANA . C-Npys (S-3-nitro-2-pyridinesulfenyl) and peptide derivatives can inhibit a serine-thiol proteinase activity from Paracoccidioides brasiliensis. Biochemical and Biophysical Research Communications (Print) , v. 355, p. 1000-1005, 2007.

• HANNA, EBERT S ; ROQUE-BARREIRA, MARIA-CRISTINA ; BERNARDES, EMERSON S ; PANUNTO-CASTELO, ADEMILSON ; SOUSA, MARCELO V ; ALMEIDA, IGOR C ; BROCCHI, MARCELO . Evidence for glycosylation on a DNA-binding protein of Salmonella enterica. Microbial Cell Factories , v. 6, p. 11, 2007.

• DE MARCHI, CLÁUDIA REGINA ; AMATO NETO, VICENTE ; ALMEIDA, Igor Correia de . Comportamento do método quimioluminescente-ELISA em relação a resultados considerados discordantes por meio de três técnicas convencionais para diagnóstico da doença de Chagas. Revista da Sociedade Brasileira de Medicina Tropical (Impresso) , v. 40, p. 68-70, 2007.

• PEREIRA, LUIZA O. R. ; OLIVEIRA, PEDRO L. ; ALMEIDA, IGOR C. ; PAIVA-SILVA, GABRIELA O. . Biglutaminyl-Biliverdin IX Alpha as a Heme Degradation Product in the Dengue Fever Insect-Vector Aedes aegypti -. Biochemistry (Easton) , v. 46, p. 6822-6829, 2007.

• FOGAÇA, ANDRÉA C. ; ALMEIDA, IGOR C. ; EBERLIN, MARCOS N. ; TANAKA, APARECIDA S. ; BULET, PHILIPPE ; DAFFRE, SIRLEI . Ixodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases. Peptides (New York, N.Y. 1980) , v. 27, p. 667-674, 2006.

• GOMES, MARTA T. ; MONTEIRO, ROBSON Q. ; GRILLO, LUCIANO A. ; LEITE-LOPES, FRANCISCO ; STROEDER, HELENI ; FERREIRA-PEREIRA, ANTONIO ; ALVIANO, CELUTA S. ; BARRETO-BERGTER, Eliana ; NETO, HUGO CASTRO-FARIA ; CUNHA E SILVA, NARCISA L. ; ALMEIDA, IGOR C. ; SOARES, ROSANGELA M.A. ; LOPES, ANGELA H. . Platelet-activating factor-like activity isolated from Trypanosoma cruzi. International Journal for Parasitology , v. 36, p. 165-173, 2006.

• LAURINO, C. C. F. C. ; FRITZLER, M. J. ; MORTARA, R. A. ; SILVA, N. P. ; ALMEIDA, I. C. ; ANDRADE, L. E. C. . Human autoantibodies to diacyl-phosphatidylethanolamine recognize a specific set of discrete cytoplasmic domains. Clinical and Experimental Immunology (Print) , v. 143, p. 572-84, 2006.

• UTZ, S. ; RODITI, I. ; KUNZ RENGGLI, C. ; ALMEIDA, I. C. ; ACOSTA-SERRANO, A. ; BUTIKOFER, P. . Trypanosoma congolense Procyclins: Unmasking Cryptic Major Surface Glycoproteins in Procyclic Forms. Eukaryotic Cell , v. 5, p. 1430-1440, 2006.

• OLIVEIRA, GISELLE A. ; BAPTISTA, DANIELA L. ; GUIMARÃES-MOTTA, HORACIO ; ALMEIDA, IGOR C. ; MASUDA, HATISABURO ; ATELLA, GEORGIA C. . Flight-oogenesis syndrome in a blood-sucking bug: Biochemical aspects of lipid metabolism. Archives of Insect Biochemistry and Physiology , v. 62, p. 164-175, 2006.

• DA CUNHA, JULIA PINHEIRO CHAGAS ; NAKAYASU, ERNESTO SATOSHI ; DE ALMEIDA, IGOR CORREIA ; SCHENKMAN, SERGIO . Post-translational modifications of Trypanosoma cruzi histone H4. Molecular and Biochemical Parasitology (Print) , v. 150, p. 268-277, 2006.

• MONTEIRO, A. C. ; SCHMITZ, V. ; SVENSJO, E. ; Gazzinelli, R. T. ; ALMEIDA, I. C. ; TODOROV, A. ; DE ARRUDA, L. B. ; TORRECILHAS, A. C. T. ; PESQUERO, J. B. ; MORROT, A. ; BOUSKELA, E. ; BONOMO, A. ; LIMA, A. P. C. A. ; MULLER-ESTERL, W. ; SCHARFSTEIN, J. . Cooperative Activation of TLR2 and Bradykinin B2 Receptor Is Required for Induction of Type 1 Immunity in a Mouse Model of Subcutaneous Infection by Trypanosoma cruzi. The Journal of Immunology (1950) , v. 177, p. 6325-6335, 2006.

• MALDONADO, ROSA A. ; KUNIYOSHI, RENATA K. ; LINSS, JUTTA G. ; ALMEIDA, IGOR C. . TRYPANOSOMA CRUZI OLEATE DESATURASE: MOLECULAR CHARACTERIZATION AND COMPARATIVE ANALYSIS IN OTHER TRYPANOSOMATIDS. The Journal of Parasitology , v. 92, p. 1064-1074, 2006.

• Paiva-Silva, G. O. ; CRUZ-OLIVEIRA, C. ; NAKAYASU, E. S. ; MAYA-MONTEIRO, C. M. ; DUNKOV, B. C. ; Masuda, H. ; ALMEIDA, I. C. ; Oliveira, P. L. . A heme-degradation pathway in a blood-sucking insect. Proceedings of the National Academy of Sciences of the United States of America (Online) , v. 103, p. 8030-8035, 2006.

• DA CUNHA, JULIA PINHEIRO CHAGAS ; NAKAYASU, ERNESTO S. ; ELIAS, MARIA CAROLINA ; PIMENTA, DANIEL C. ; TELLEZ-INON, MARIA TERESA ; ROJAS, FEDERICO ; MANUEL, MUOZ ; ALMEIDA, IGOR C. ; SCHENKMAN, SERGIO . Trypanosoma cruzi histone H1 is phosphorylated in a typical cyclin dependent kinase site accordingly to the cell cycle. Molecular and Biochemical Parasitology (Print) , v. 140, p. 75-86, 2005.

• NIMRICHTER, L. ; CERQUEIRA, M. D. ; LEITAO, E. A. ; MIRANDA, K. ; NAKAYASU, E. S. ; ALMEIDA, S. R. ; ALMEIDA, I. C. ; ALVIANO, C. S. ; BARRETO-BERGTER, E. ; RODRIGUES, M. L. . Structure, Cellular Distribution, Antigenicity, and Biological Functions of Fonsecaea pedrosoi Ceramide Monohexosides. Infection and Immunity (Print) , v. 73, p. 7860-7868, 2005.

• Campos, M. A. ; Rosinha, G. M. ; Almeida, I. C. ; ALMEIDA, Igor Correia de ; Salgueiro, X. S. ; Jarvis, B. W. ; Splitter, G. A. ; Qureshi, N. ; Bruna-Romero, O. ; Gazzinelli, R. T. ; Oliveira, S. C. . Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Infection and Immunity , Estados Unidos, v. 72, n.1, p. 176-186, 2004.

• BUSCAGLIA, C ; CAMPO, V ; NOIA, J Di ; TORRECILLHAS, A C T ; MARCHI, C R de ; FERGUSON, M A J ; FRASCH, A C C ; ALMEIDA, Igor Correia de . The surface coat of the mammalian-dwelling infective Trypomastigote stage of Trypanosoma cruzi is formed by highly diverse immunogenic mucins. The Journal of Biological Chemistry , EUA, v. 279, n.16, p. 15860-15869, 2004.

• da SILVA, André F C ; RODRIGUES, Marcio L ; FARIAS, Sandra E ; ALMEIDA, Igor Correia de ; PINTO, Marcia R ; BARRETO-BERGTER, Eliana . Glucosylceramides in Colletotrichum gloeosporioides are involved in the differentiation of conidia into mycelial cells.. FEBS Letters , EUA, v. 561, p. 137-143, 2004.

• MALLEY, R ; MORSE, S C ; LEITE, L C ; AREAS, A P ; HO, P L ; KUBRUSLY, F S ; ALMEIDA, Igor Correia de ; ANDERSON, P . Multiserotype Protection of Mice against Pneumococcal Colonization of the Nasopharynx and Middle Ear by Killed Nonencapsulated Cells Given Intranasally with a Nontoxic Adjuvant. Infection and Immunity , EUA, v. 72, p. 4290-4292, 2004.

• ANDRADE, A L S S ; MARTELLI, C M T ; OLIVEIRA, R M ; SILVA, S A ; SOUSSUMI, L M T ; COVAS, D T ; SILVA, L S ; ANDRADE, J G ; TRAVASSOS, L R ; ALMEIDA, Igor Correia de . Benznidazole efficacy among Trypanosoma cruzi-infected adolescents after 6-year follow-up. American Journal of Tropical Medicine and Hygiene , v. press, 2004.

• CASSERA, MARÍA B. ; GOZZO, FABIO C. ; D'ALEXANDRI, FABIO L. ; MERINO, EMILIO F. ; DEL PORTILLO, HERNANDO A. ; PERES, VALNICE J. ; ALMEIDA, IGOR C. ; EBERLIN, MARCOS N. ; WUNDERLICH, GERHARD ; WIESNER, JOCHEN ; JOMAA, HASSAN ; KIMURA, EMILIA A. ; KATZIN, ALEJANDRO M. . The Methylerythritol Phosphate Pathway Is Functionally Active in All Intraerythrocytic Stages of Plasmodium falciparum. The Journal of Biological Chemistry (Print) , v. 279, p. 51749-51759, 2004.

• ZAMBONI, D. S. ; Campos, M. A. ; TORRECILHAS, A. C. T. ; KISS, K. ; SAMUEL, J. E. ; GOLENBOCK, D. T. ; LAUW, F. N. ; ROY, C. R. ; ALMEIDA, I. C. ; Gazzinelli, R. T. . Stimulation of Toll-like Receptor 2 by Coxiella burnetii Is Required for Macrophage Production of Pro-inflammatory Cytokines and Resistance to Infection. Journal of Biological Chemistry (Online) , v. 279, p. 54405-54415, 2004.

• ANDRADE, A.L.S.S ; MARTELLI, C. M. T. ; OLIVEIRA, R. M. ; SILVA, S. A. ; AIRES, A. I. S. ; SOUSSUMI, L. M. T. ; COVAS, D. T. ; SILVA, L. S. ; ANDRADE, J. G. ; TRAVASSOS, L. R. ; ALMEIDA, I. C. . Benznidazole efficacy among Trypanosoma cruzi-infected adolescents after a six-year follow-up.. The American Journal of Tropical Medicine and Hygiene , v. 71, p. 594-597, 2004.

• Lara, F. A. ; Lins, U. ; Paiva-Silva, G. ; ALMEIDA, Igor Correia de ; Braga, C. M. ; Miguens, F. C. ; Oliveira, P. L. ; Dansa-Petretski, M. . A new intracellular pathway of haem detoxification in the midgut of the cattle tick Boophilus microplus: aggregation inside a specialized organelle, the hemosome. Journal of Experimental Biology , Estados Unidos, v. 206, n.10, p. 1707-1715, 2003.

• Zufferey, R. ; Allen, S. ; Barron, T. ; Sullivan, D. R. ; Denny, P. W. ; ALMEIDA, Igor Correia de ; Smith, D. F. ; Turco, S. J. ; Ferguson, M. A. ; Beverley, S. M. . Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major. The Journal of Biological Chemistry , Estados Unidos, v. 278, n.45, p. 44708-44718, 2003.

• Di NOIA, J M ; BUSCAGLIA, C A ; MARCHI, C R de ; ALMEIDA, I C ; ALMEIDA, Igor Correia de ; FRASCH, A C C . A Trypanosoma cruzi small surface molecule provides the first immunological evidence that Chagas'disease is due to a single parasite lineage. Journal of Experimental Medicine , Estados Unidos, v. 195, n.4, p. 401-413, 2002.

• Soares, R. P. ; Macedo, M. E. ; Ropert, C. ; Gontijo, N. F. ; ALMEIDA, Igor Correia de ; Gazzinelli, R. T. ; Pimenta, P. F. ; Turco, S. J. . Leishmania chagasi: lipophosphoglycan characterization and binding to the midgut of the sand fly vector Lutzomyia longipalpis. Molecular and Biochemical Parasitology , Estados Unidos, v. 121, n.2, p. 213-224, 2002.

• Ropert, C. ; Ferreira, L. R. ; Campos, M. A ; Procopio, D. O. ; Travassos, L. R. ; Ferguson, M. A. ; Reis, L. F. ; Teixeira, M. M. ; ALMEIDA, Igor Correia de ; Gazzinelli, R. T. . Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes. Microbes and Infection , França, v. 4, n.9, p. 1015-1025, 2002.

• Paiva-Silva, G. O. ; Sorgine, M. H. ; Benedetti, C. E. ; Meneghini, R. ; Almeida, I. C. ; ALMEIDA, Igor Correia de ; Machado, E. A. ; Dansa-Petretski, M. ; Yepiz-Plascencia, G. ; Law, J. H. ; Oliveira, P. L. ; Masuda, H. . On the biosynthesis of Rhodnius prolixus heme-binding protein. Insect Biochemistry and Molecular Biology , Estados Unidos, v. 32, n.11, p. 1533-1541, 2002.

• Procopio, D. O. ; ALMEIDA, Igor Correia de ; Torrecilhas, A. C. ; Cardoso, J. E. ; Teyton, L. ; Travassos, L. R. ; Bendelac, A. ; Gazzinelli, R. T. . Glycosylphosphatidylinositol-anchored mucin-like glycoproteins from Trypanosoma cruzi bind to CD1d but do not elicit dominant innate or adaptive immune responses via the CD1d/NKT cell pathway. Journal of Immunology (Baltimore) , Estados Unidos, v. 169, n.7, p. 3926-3933, 2002.

• ROPERT, C ; ALMEIDA, Igor Correia de ; CLOSEL, M ; TRAVASSOS, L R ; FERGUSON, M A J ; COHEN, P ; Gazzinelli, R T . Requirement of mitogen-activated protein kinases and IkappaB phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial lipopolysaccharide.. Journal of Immunology (Baltimore) , EUA, v. 166, n.5, p. 3423-3431, 2001.

• ALMEIDA, Igor Correia de ; Gazzinelli, R T . Proinflammatory activity of glycosylphosphatidylinositol anchors derived from Trypanosoma cruzi: structural and functional analyses. J Leukoc Biol, EUA, v. 70, n.4, p. 467-477, 2001.

• Campos, M A ; ALMEIDA, I C ; ALMEIDA, Igor Correia de ; Takeuchi, O ; Akira, S ; Valente, E P ; Procopio, D O ; TRAVASSOS, L R ; Smith, J A ; Golenbock, D T ; Gazzinelli, R T . Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. Journal of Immunology (Baltimore) , EUA, v. 167, n.1, p. 416-426, 2001.

• SERRANO, A A ; ALMEIDA, I C ; ALMEIDA, Igor Correia de ; FREITAS-JUNIOR, L H ; YOSHIDA, N ; Schenkman, S. . The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles. Mol Biochem Parasitol, v. 114, n.2, p. 143-150, 2001.

• LISCHKE, A. ; KLEIN, C. ; STIERHOF, Y. D. ; HEMPEL, M. ; MEHLERT, A. ; ALMEIDA, Igor Correia de ; FERGUSON, M A J ; OVERATH, P. . Isolation and characterization of glycosylphosphatidylinositol-anchored, mucin-like surface glycoproteins from bloodstream forms of the freshwater-fish parasite Trypanosoma carassii.. Biochemical Journal (London) , England, v. 345, n.3, p. 693-700, 2000.

• Pereira-Chioccola, V. L. ; Acosta-Serrano, A. ; ALMEIDA, Igor Correia de ; FERGUSON, M A J ; Souto-Padron, T. ; Rodrigues, M M ; TRAVASSOS, L R ; Schenkman, S. . Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-(alpha)-galactosyl antibodies.. Journal of Cell Science , England, v. 113, n.7, p. 1299-1307, 2000.

• ALMEIDA, Igor Correia de ; CAMARGO, M. M. ; Procopio, D O ; SILVA, L S ; MEHLERT, A. ; TRAVASSOS, L R ; Gazzinelli, R T ; FERGUSON, M A J . Highly-purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents.. EMBO Journal , England, v. 19, n.7, p. 1476-1485, 2000.

• TALVANI, A. ; RIBEIRO, C. S. ; ALIBERTI, J. C. S. ; MICHAILOWSKY, V. ; SANTOS, P. V. A. ; MURTA, S. M. F. ; ROMANHA, A. J. ; ALMEIDA, Igor Correia de ; FARBER, J. ; LANNES-VIEIRA, J ; SILVA, J. S. ; Gazzinelli, R T . Kinetics of cytokine genes expression in experimental chagasic cardiomyopathy: tissue parasitism and IFN-g as important determinants of chemokine mRNAs expression during infection with Trypanosoma cruzi. Microbes And Infection, França, v. press, n.in press, 2000.

• Panunto-Castello, A ; ALMEIDA, Igor Correia de ; Rosa, J. C. ; Greene, L. J. ; Roque-Barreira, M. C. . The Rubino test for leprosy is a b2-glycoprotein I-dependent antiphospholipid reaction.. Immunology (Oxford) , Reino Unido, v. press, n.in press, 2000.

• GIRALDO, M. ; CANNIZZARO, H. ; FERGUSON, M. A. J. ; ALMEIDA, Igor Correia de ; Gazzinelli, R T . Fractionation of membrane components from tachyzoite forms of toxoplasma gondii: differential recognition by immunoglobulin M (IgM) and IgG present in sera from patients with acute or chronic toxoplasmosis. Journal of Clinical Microbiology , Estados Unidos, v. 38, p. 1453-1460, 2000.

• Gazzinelli, R T ; Rodrigues, M M ; ALMEIDA, I C ; ALMEIDA, Igor Correia de ; TRAVASSOS, L R . Role of parasite surface glycoconjugates on induction/regulation of immune responses and inflammation elicited during Trypanosoma cruzi infection: potential implications on pathophysiology of Chagas'disease. Ciência e Cultura (SBPC) , São Paulo, v. 51, p. 411-428, 2000.

• Maya-Monteiro, C M ; Daffre, S ; Logullo, C ; Lara, F A ; Alves, E W ; Capurro, M L ; Zingali, R ; ALMEIDA, Igor Correia de ; Oliveira, P L . HeLp, a heme lipoprotein from the hemolymph of the cattle tick, boophilus microplus. The Journal of Biological Chemistry , Estados Unidos, v. 275, n.47, p. 36584-36589, 2000.

• PROCOPIO, D. O. ; TEIXEIRA, M M ; CAMARGO, M. M. ; TRAVASSOS, L. R. ; FERGUSON, M. A. J. ; ALMEIDA, Igor Correia de ; GAZZINELI, R. T. . Differential inhibitory mechanism of cyclic AMP on TNF-alpha and IL-12 synthesis by macrophages exposed to microbial stimuli.. British Journal of Pharmacology , England, v. 127, n.5, p. 1195-1205, 1999.

• BRANQUINHA, M. H. ; VERMELHO, A. B. ; ALMEIDA, Igor Correia de ; MEHLERT, A. ; FERGUSON, M. A. J. . Structural studies on the polar glycoinositol phospholipids of Trypanosoma (Schizotrypanum) dionisii from bats.. Molecular and Biochemical Parasitology , Netherlands, v. 102, n.1, p. 179-189, 1999.

• ALMEIDA, Igor Correia de ; ALMEIDA, I C ; Gazzinelli, R T ; FERGUSON, M A J ; TRAVASSOS, L R . Trypanosoma cruzi mucins: potential functions of a complex structure.. Brazilian Journal of Medical and Biological Research , Brazil, v. 94, n.1, p. 173-176, 1999.

• CAMARGO, M. M. ; ALMEIDA, Igor Correia de ; PEREIRA, M. E. ; FERGUSON, M A J ; TRAVASSOS, L R ; GAZZINELLI, R. T. . Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes initiate the synthesis of proinflammatory cytokines by macrophages.. Journal of Immunology (Baltimore) , United States, v. 158, n.12, p. 5890-5901, 1997.

• ALMEIDA, Igor Correia de ; COVAS, D. T. ; SOUSSUMI, L. M. T. ; TRAVASSOS, L. R. . A highly sensitive and specific chemiluminescent enzyme-linked immunosorbent assay for diagnosis of active Trypanosoma cruzi infection.. Transfusion (Arlington) , United States, v. 37, n.8, p. 850-857, 1997.

• Gazzinelli, R T ; CAMARGO, M. M. ; ALMEIDA, Igor Correia de ; MORITA, Y. S. ; GIRALDO, M. ; ACOSTA-SERRANO, A. ; HIENY, S. ; ENGLUND, P. T. ; FERGUSON, M A J ; SHER, A. . Identification and characterization of protozoan products that trigger the synthesis of IL-12 by inflammatory macrophages.. CHEMICAL IMMUNOLOGY , Switzerland, v. 68, p. 136-152, 1997.

• CAMARGO, M. M. ; ANDRADE, A. C. ; ALMEIDA, Igor Correia de ; TRAVASSOS, L R ; Gazzinelli, R T . Glycoconjugates isolated from Trypanosoma cruzi but not from Leishmania species membranes trigger nitric oxide synthesis as well as microbicidal activity in IFN-gamma-primed macrophages.. Journal of Immunology (Baltimore) , United States, v. 159, n.12, p. 6131-6139, 1997.

• ALMEIDA, Igor Correia de ; NEVILLE, D. C. ; MEHLERT, A. ; TREUMANN, A. ; FERGUSON, M. A. J. ; PREVIATO, J. O. ; TRAVASSOS, L. R. . Structure of the N-linked oligosaccharide of the main diagnostic antigen of the pathogenic fungus Paracoccidioides brasiliensis. Glycobiology (Oxford) , England, v. 6, n.5, p. 507-515, 1996.

• DE ANDRADE, A. L. ; ZICKER, F. ; DE OLIVEIRA, R. M. ; ALMEIDA SILVA, S. ; LUQUETTI, A. ; TRAVASSOS, L. R. ; ALMEIDA, Igor Correia de ; DE ANDRADE, S. S. ; DE ANDRADE, J. G. ; MARTELLI, C. M. . Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet , England, v. 348, n.9039, p. 1407-1413, 1996.

• TRAVASSOS, L. R. ; PUCCIA, R. ; CISALPINO, P. ; TABORDA, C. ; RODRIGUES, E. G. ; RODRIGUES, M. ; SILVEIRA, J. F. ; ALMEIDA, Igor Correia de . Biochemistry and molecular biology of the main diagnostic antigen of Paracoccidioides brasiliensis.. Archives of Medical Research , Mexico, v. 26, n.3, p. 297-304, 1995.

• SOUTO-PADRON, T. ; ALMEIDA, Igor Correia de ; DE SOUZA, W. ; TRAVASSOS, L. R. . Distribution of alpha-galactosyl-containing epitopes on Trypanosoma cruzi trypomastigote and amastigote forms from infected Vero cells detected by Chagasic antibodies.. The Journal of Eukaryotic Microbiology , United States, v. 41, n.1, p. 47-54, 1994.

• ALMEIDA, Igor Correia de ; RODRIGUES, E. G. ; TRAVASSOS, L. R. . Chemiluminescent immunoassays: discrimination between the reactivities of natural and human patient antibodies with antigens from eukaryotic pathogens, Trypanosoma cruzi and Paracoccidioides brasiliensis.. Journal of Clinical Laboratory Analysis , United States, v. 8, n.6, p. 424-431, 1994.

• ALMEIDA, Igor Correia de ; FERGUSON, M. A. J. ; SCHENKMAN, S. ; TRAVASSOS, L. R. . GPI-anchored glycoconjugates from Trypanosoma cruzi trypomastigotes are recognized by lytic anti-alpha-galactosyl antibodies isolated from patients with chronic Chagas'disease.. Brazilian Journal of Medical and Biological Research , Brazil, v. 27, n.2, p. 443-447, 1994.

• ALMEIDA, Igor Correia de ; FERGUSON, M. A. J. ; SCHENKMAN, S. ; TRAVASSOS, L. R. . Lytic anti-alpha-galactosyl antibodies from patients with chronic Chagas'disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi.. Biochemical Journal (London) , England, v. 304, n.3, p. 793-802, 1994.

• TRAVASSOS, L. R. ; ALMEIDA, Igor Correia de . Carbohydrate immunity in American trypanosomiasis.. Springer Seminars in Immunopathology , Germany, v. 15, n.2-3, p. 183-204, 1993.

• ALMEIDA, Igor Correia de ; KRAUTZ, G. M. ; KRETLLI, A. U. ; TRAVASSOS, L. R. . Glycoconjugates of Trypanosoma cruzi: a 74 kD antigen of trypomastigotes specifically reacts with lytic anti-alpha-galactosyl antibodies from patients with chronic Chagas disease.. Journal of Clinical Laboratory Analysis , United States, v. 7, n.6, p. 307-316, 1993.

• TRAVASSOS, L R ; ALMEIDA, Igor Correia de ; TAKAHASHI, H. K. . Antibody specificity in the conventional serology for Chagas disease. Ciência e Cultura (SBPC) , São Paulo, v. 46, p. 242-248, 1993.

• GUTIERREZ, P.S. ; ALMEIDA, Igor Correia de ; NADER, H.B. ; DIETRICH, C. P. . Decrease in sulphated glycosaminoglycans in aortic dissection - possible role in the pathogenesis.. Cardiovascular Research , England, v. 25, n.9, p. 742-748, 1991.

• ALMEIDA, Igor Correia de ; MILANI, S R ; GORIN, P A ; TRAVASSOS, L R . Complement-mediated lysis of Trypanosoma cruzi trypomastigotes by the human anti-alfa-galactosyl antibodies. Journal of Immunology (Baltimore) , United States, v. 146, n.7, p. 2394-2400, 1991.

• YICHOY, M. ; NAKAYASU, E. S. ; CHATTERJEE, A. ; ALMEIDA, I. C. ; DAS, S. . Giardia: A Model Organism. 1. ed. Austria: Springer, 2011. v. 1. 420p .

• ORTEGA-RODRIGUEZ, URIEL ; PORTILLO, SUSANA ; ASHMUS, ROGER A. ; Duran, Jerry A. ; SCHOCKER, NATHANIEL S. ; INIGUEZ, EVA ; MONTOYA, ALBA L. ; ZEPEDA, BRENDA G. ; OLIVAS, JANET J. ; KARIMI, NASIM H. ; ALONSO-PADILLA, JULIO ; IZQUIERDO, LUIS ; Pinazo, Maria-Jesús ; de Noya, Belkisyolé Alarcón ; NOYA, OSCAR ; MALDONADO, ROSA A. ; TORRICO, FAUSTINO ; GASCON, JOAQUIM ; MICHAEL, KATJA ; ALMEIDA, IGOR C. . Purification of Glycosylphosphatidylinositol-Anchored Mucins from Trypanosoma cruzi Trypomastigotes and Synthesis of -Gal-Containing Neoglycoproteins: Application as Biomarkers for Reliable Diagnosis and Early Assessment of Chemotherapeutic Outcomes(...). Methods in Molecular Biology. 1ed.: Springer New York, 2019, v. , p. 287-308.

• SCHOCKER, NATHANIEL S. ; PORTILLO, SUSANA ; ASHMUS, ROGER A. ; BRITO, CARLOS R. N. ; Silva, Igor E. ; Mendoza, Yanira Cordero ; MARQUES, ALEXANDRE F. ; MONROY, ERIKA Y. ; PARDO, ANDREW ; IZQUIERDO, LUIS ; GÁLLEGO, MONTSERRAT ; GASCON, JOAQUIM ; ALMEIDA, IGOR C. ; MICHAEL, KATJA . Probing forTrypanosoma cruzi Cell SurfaceGlycobiomarkers for the Diagnosis and Follow-Up of Chemotherapy of Chagas Disease. Coupling and Decoupling of Diverse Molecular Units in Glycosciences. 1ed.: Springer International Publishing, 2018, v. , p. 195-211.

• Yichoy, M ; Nakayasu, ES ; Chatterjee, A ; Aley, SB ; Igor C. Almeida ; Das, S . Mass Spectrometric Analysis of Phospholipids and Fatty Acids in Giardia lamblia. In: Hugo D. Lujan; Staffan Svard. (Org.). Giardia: A Model Organism. #ed.Vienna: Springer, 2011, v. , p. 1-.

• ALMEIDA, I. C. ; ACOSTA-SERRANO, A. ; HUTCHINSON, C. ; NAKAYASU, E. S. ; CARRINGTON, M. . Chapter 10: Comparison and Evolution of the Surface Architecture of Trypanosomatid Parasites. In: David Barry; Richard McCulloch; Jeremy Mottram; Alvaro Acosta-Serrano. (Org.). Trypanosomes: After the Genome. 1ed.: Horizon Bioscience, 2007, v. 1, p. 1-478.

• Teixeira, M. M. ; ALMEIDA, Igor Correia de ; Gazzinelli, R. T. . Introduction: innate recognition of bacteria and protozoan parasites. Microbes And Infection , França, v. 4, n.9, p. 883-886, 2002.

Outras produções

Projetos de pesquisa

• 2019 - Atual

  Border Biomedical Research Center - Research Infrastructure Core (RIC), Descrição: To provide BBRC faculty, staff and students full access to cutting-edge instrumentation for biochemical and mass spectrometric analysis of biomolecules from organisms of biomedical relevance.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador / Kirken, Robert - Integrante.

• 2018 - 2021

  Differential diagnosis of cutaneous leishmaniasis by immunoassays with density controlled presentation of glycan biomarkers, Descrição: Discovery of glycan biomarkers for the reliable diagnosis of cutaneous leishmaniasis. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Integrante / Michael Katja - Coordenador.

• 2018 - Atual

  New Chemotherapy Regimens and Biomarkers for Chagas Disease, Descrição: The goal of this clinical trial is to test new regimens of the two current drugs for Chagas disease to improve their safety and efficacy, and develop and test novel diagnostic tools (biomarkers) that will provide a more efficient measure of disease state and treatment outcomes.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador.

• 2018 - Atual

  Role of CD4-CD8- DN T cells in Chagas Cardiomyopathy, Descrição: To study the role of CD4-CD8-DN T cells and CD1 in the cardiomyopathy of Chagas disease. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador / Dutra, Walderez - Integrante.

• 2017 - Atual

  Glycogen in Bacterial Vaginosis & How Carbohydrates Shape the Vaginal Microbiome, Descrição: To examine the proteomes of human vaginal specimens in search of the bacterial enzymes that break down carbohydrates and could be involved in bacterial vaginosis, which is associated with higher risks and many serious reproductive health complications in women. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador / LEWIS, WARREN - Integrante.

• 2014 - 2019

  Border Biomedical Research Center, Descrição: To provide BBRC faculty, staff and students full access to cutting-edge instrumentation for biochemical and mass-spectrometric analysis of biomolecules from organisms of biomedical relevance. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador / Kirken, Robert - Integrante.

• 2014 - 2017

  Novel Vaccine for Chagas Disease: Efficacy Testing in Baboons, Descrição: Over the years, various groups have developed experimental vaccines, using mainly parasite lysates, or purified or recombinant proteins and peptides, and DNA, targeting almost exclusively protein antigens. Most, if not all, of these vaccines, however, have failed to provide sterile protection to animals challenged with different parasite strains. Although glycoconjugates (i.e., glycolipids and glycoproteins) are the major antigens on T. cruzi surface and contain highly immunogenic epitopes, they remain practically unexplored as vaccine targets. Patients with acute or chronic ChD, from diverse geographical locations in Latin America, have very high titers of trypanolytic anti--galactosyl antibodies (Ch anti--Gal Abs). These antibodies are protective and thought to be the major host immune mechanism controlling parasitemia at both acute and chronic stages of ChD. Ch anti--Gal Abs recognize highly immunogenic terminal, non-reducing -Gal-containing epitopes or glycotopes abundantly expressed on major immunodominant glycoproteins (i.e., mucins and TS/gp85 glycoproteins) of the mammal-dwelling trypomastigote forms. Since these -Gal epitopes are absent in human cells, we propose that an effective ChD vaccine could be obtained using these immunodominant B-cell epitopes. The experimental glycoconjugate or neoglycoprotein (NGP) vaccine, developed by Dr. Almeida (PI) and Dr. Katja Michael (Chemistry Dept., UTEP) (Co-PI), is based on a linear glycan (Gal1,3Gal1,4GlcNAc, or Gal3LN or KM24) that exists naturally on the surface of T. cruzi, and does not exist in humans and Old World primates such as baboons. Therefore, this T. cruzi sugar is detected as a foreign substance and a powerful immune response is mounted against it in patients with ChD and in transgenic mice lacking this glycotope. After experimental immunization with KM24 coupled to a carrier protein (bovine serum albumin, BSA) (NGP KM24b), the immune system of the immunized animals are primed to recognize T. cruzi as foreign and to kill the parasites soon after they enter the blood stream, and before they can get into cells where they reproduce. The KM24b vaccine also induces strong CD4 (helper) T cell activation, as observed with other glycoconjugate vaccines, and production of cytokines essential for isotype switching (from IgM to IgG) and differentiation of activated B cells into memory B cells, thus leading to a long-term immunity. Animals vaccinated with KM24b show 100% protection against two consecutive lethal parasite challenges and 99.9% parasite load reduction in the heart, as measured by qRT-PCR. Finally, lytic anti--Gal Abs purified from KM24b-immunized mice, are able to partially protect mice against T. cruzi infection, indicating a potential therapeutic value of this NGP vaccine. In addition to the KM24h vaccine, Dr. Almeida and collaborator (Dr. Rosa A. Maldonado, UTEP) have developed a peptide vaccine (MASPpep), based on a highly abundant and immunogenic surface antigen (mucin-associated surface glycoprotein, MASP), secreted by infective T. cruzi mammal-dwelling trypomastigote forms. MASPpep differs from previous peptides used as experimental ChD vaccines, because it is a longer (20-mer) peptide containing multiple B cell and CD4 and CD8 T-cell epitopes. Thus, it elicits a strong anti-T. cruzi immune response in mice mediated by both B and T cells, resulting in a very good protection (~86%) against lethal parasite challenge. Mice vaccinated with MASPpep also show 97% reduction of parasite load in the heart. Our rationale to test MASPpep as vaccine candidate in baboons, alone or in combination with KM24h, is that together, these immunogens could strongly elicit both B and T cell-mediated immune responses, leading to a fully protective and, ideally, sterile vaccine against T. cruzi.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador / Jonh Vanderberg - Integrante.

• 2014 - 2017

  Synthetic neoglycopeptides as Chagas disease vaccines, Descrição: Chagas disease (ChD) is a devastating neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. It is estimated that 8-11 million people are chronically infected in Latin America, representing a substantial social and economic burden. Owing to the extensive global migration of asymptomatic, chronically infected individuals from endemic regions, ChD now affects thousands of people in nonendemic regions like North America and Europe. The two available drugs for ChD chemotherapy have limited efficacy in the chronic phase of the disease and are rather toxic. Moreover, there is no preventive or therapeutic vaccine for human ChD, despite numerous experimental efforts targeting almost entirely parasite proteins. Although glycoconjugates are the major surface molecules of the infective trypomastigote stages (from both insect vector and host cells), they remain completely unexplored as vaccine targets. Highly abundant T. cruzi trypomastigote surface glycoconjugates, such as glycosylphosphatidylinositol (GPI)-anchored mucin glycoproteins (tGPI-mucins), contain highly immunogenic terminal -galactopyranosyl residues (-Gal), which are not expressed in human cells. Accordingly, very high levels of trypanolytic, protective anti--Gal antibodies are observed in both acute and chronic stages of human ChD. We thus hypothesized that terminal -Gal-containing epitopes could be highly effective vaccines for ChD. To test our hypothesis, we recently employed the 1,3-galactosyltransferase-knockout (1,3GalT-KO) mouse model, which closely mimics the human humoral immune response against T. cruzi. As immunogen, we used the synthetic trisaccharide Gal1,3Gal1,4GlcNAc (Gal3LN), which is one of the major O-glycans on tGPI-mucins, covalently linked to bovine serum albumin (BSA) as carrier protein. Gal3LN-BSA-immunized mice showed very high levels of protective anti--Gal antibodies, much lower parasitemia, and very low parasite levels in the heart, as compared to control BSA-immunized animals. Although not sterile, the protection induced by the Gal3LN-BSA vaccine was long lasting and dependent on CD4+ (helper) T cells. Based on these results, we hypothesize that the ideal vaccine for ChD should induce both humoral (B cell) and cellular (T cell) immune responses, since both lytic antibodies and T cells play a decisive role in controlling T. cruzi infection. Aiming at the generation of a ChD vaccine that provides sterile protection against T. cruzi mediated by both B and T cells, here we plan to synthesize a series of neoglycopeptides (NGPs) consisting of a well-characterized major histocompatibility complex class II (MHCII)-binding peptide, i.e., tetanus toxoid peptide (TTp) or ovalbumin peptide (OVAp), covalently linked to the immunodominant Gal3LN epitope. These synthetic NGPs will be employed for the immunization of 1,3GalT-KO mice and the B and T cell-mediated immune responses will be examined. To achieve these objectives, we propose three specific aims: Specific Aim 1: Chemical synthesis of 1,3-Gal-containing neoglycopeptides. Specific Aim 2: Vaccination of 1,3GalT-KO mice with synthetic 1,3-Gal-containing neoglycopeptides and evaluation of the protective B cell-mediated immune response. Specific Aim 3: Elucidation of T cell-dependent immune mechanisms by synthetic T. cruzi glycan epitopes. We anticipate that high levels of protective anti--Gal antibodies will be achieved following immunization with the synthetic NGPs. In addition, we will learn which NGP architecture(s) will be ideal for achieving long-term, sterile protection against T. cruzi, dependent on both B and helper T cells. We strongly believe that this project will establish the basis for development of the first synthetic glycoconjugate vaccine able to induce a long-term, sterile protection against T. cruzi.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador / Michael Katja - Integrante.

• 2014 - 2017

  Mechanisms in viral RNA replication complex assembly: novel targets for antiviral therapy, Descrição: The major goals of this project are to examine the role of post-translational modification of the Nodamura virus RNA-dependent RNA polymerase in its localization to viral RNA replication complexes in the cell. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador / JOHNSON, KYLE - Integrante.

• 2014 - 2014

  Exploration of the CD4 T-cell dependent humoral immune response to synthetic tetanus toxoid peptide-glycan conjugates as vaccines for Chagas disease, Descrição: To evaluate synthetic neoglycopeptides vaccine for Chagas disease in mice.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador / Michael Katja - Integrante.

• 2013 - 2017

  Global Characterization of Protein Palmitoylation in Trypanosomes, Descrição: Dual acylation with myristate and palmitate is essential for targeting of some proteins to specific lipid domains, and is commonly observed on eukaryotic cell signalling molecules. While N-myristoylation is carried out by a single N-myristoyltransferase, S-palmitoylation is mediated by one of a number of palmitoyl acyltransferases (PAT), each having its own subcellular location and substrate specificity. Palmitoylation is an essential modification in all eukaryotes. One goal of our research is to define for the first time the subcellular locations and substrates of every PAT in a eukaryotic cell. We have chosen the single-celled eukaryote Trypanosoma brucei for our studies, an excellent model system for this kind of analysis given its complex cell structure and powerful genetic tools. Over half a billion people are at risk of infection with one of three neglected tropical pathogens: Trypanosoma brucei, the agent of African sleeping sickness (60 million), Trypanosoma cruzi, the agent of Chagas disease (100 million), and Leishmania species (350 million), the agents of cutaneous, visceral and mucocutaneous leishmaniasis. There is no vaccine to prevent and/or treat any of these neglected diseases. Moreover, the drugs available for treating these infections suffer from poor efficacy and high toxicity. There are species-specific PATs in all organisms. Therefore, PAT inhibition may be a potentially novel drug target for the treatment of these and other infections with eukaryotic pathogens. A complementary aspect of our work will be the identification of those palmitoylating enzymes that are necessary for parasite growth and survival during infection and are therefore potential drug targets. The Specific Aims of this project are: - To determine the palmitoyl acyltransferase-specific palmitoyl proteomes and map palmitoylation sites in T. brucei. - To localize each of the 12 T. brucei palmitoyl acyltransferases and selected substrates. - To investigate the palmitoyl acyltransferases as potential in vivo drug targets.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Integrante / David Engman - Coordenador.

• 2011 - 2017

  Sphingolipid and Mechanism of Cyst Formation by Giardia, Descrição: To elucidate the mechanism by which glucosylceramide transferase-1 regulates the biogenesis of encystation-specific vesicles (ESVs) and viability of giardial cysts. My role is to advise and help the PI in designing experiments related to mass spectrometry.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Integrante / DAS, SIDDHARTHA - Coordenador.

• 2010 - 2012

  Molecular Composition and Function of Trypanosoma cruzi Shed Vesicles, Descrição: To understand how T. cruzi shed vesicles secreted by the parasite are able to interact with host effector (receptor) molecules, leading to cell invasion and continuous escape from host immunity.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador.

• 2009 - 2013

  Synthesis of immunogenic glycolipopeptides for the development of vaccines for Chagas disease, Descrição: To chemically synthesize immunogenic glycolipopeptides to be used as experimental Chagas disease vaccine. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Integrante / Katja Michael - Coordenador.

• 2007 - 2013

  Molecular Composition and Function of Trypanosoma cruzi Shed Vesicles, Descrição: To understand how T. cruzi shed vesicles secreted by the parasite are able to interact with host effector (receptor) molecules, leading to cell invasion and continuous escape from host immunity.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador.

• 2007 - 2011

  Identification and validation of novel antigenic targets in Trypanosoma cruzi, Descrição: To validate novel antigenic targets in Trypanosoma cruzi for vaccine development. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador.

• 2004 - 2006

  Structure and Immunological Function of Trypanosoma cruzi Glycosylphosphatidylinositol (GPI)-anchored glycoconjugates, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Igor Correia de Almeida - Coordenador.

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