Geysson Javier Fernandez Garcia

Pós-doutorado

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Orientou

Produções bibliográficas

• MORAES, DIOGO DE ; MOUSOVICH-NETO, FELIPPE ; CURY, SARAH SANTILONI ; OLIVEIRA, JAKELINE ; SOUZA, JEFERSON DOS SANTOS ; FREIRE, PAULA PACCIELLI ; DAL-PAI-SILVA, MAELI ; MORI, MARCELO ALVES DA SILVA ; FERNANDEZ, GEYSSON JAVIER ; CARVALHO, ROBSON FRANCISCO . The Transcriptomic Landscape of Age-Induced Changes in Human Visceral Fat and the Predicted Omentum-Liver Connectome in Males. Biomedicines , v. 11, p. 1446, 2023.

• SANTOS, DRIÉLE B. ; FERNANDEZ, GEYSSON J. ; PARDINI, LUCIANA M. C. ; PARDINI, MARIA INÊS M. C. ; FERRASI, ADRIANA C. . Transcriptomic Profile of Canine Mammary Ductal Carcinoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 24, p. 5212, 2023.

• MONTAÑO MENDOZA, VICKY MARGARITA ; MENDEZ CORTINA, YORJAGIS ANDRES ; RODRÍGUEZ-PEREA, ANA LUCÍA ; FERNANDEZ, GEYSSON JAVIER ; RUGELES, MARÍA TERESA ; VELILLA HERNANDEZ, PAULA A. ; CARDONA MAYA, WALTER D. . Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection. HELIYON , v. 9, p. e13045, 2023.

• FERNANDEZ, GEYSSON JAVIER ; RAMÍREZ-MEJÍA, JULIETA M ; CASTILLO, JORGE ANDRÉS ; URCUQUI-INCHIMA, SILVIO . Vitamin D modulates expression of antimicrobial peptides and proinflammatory cytokines to restrict Zika virus infection in macrophages. INTERNATIONAL IMMUNOPHARMACOLOGY , v. 119, p. 110232, 2023.

• FRAGOSO, MARIANA F. ; FERNANDEZ, GEYSSON J. ; VANDERVEER, LISA ; COOPER, HARRY S. ; SLIFKER, MICHAEL ; CLAPPER, MARGIE L. . Dysregulation of miR-1-3p: An Early Event in Colitis-Associated Dysplasia. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 23, p. 13024, 2022.

• DE PAULA, TASSIANA GUTIERREZ ; ZANELLA, BRUNA TEREZA THOMAZINI ; DE MORAES, LEONARDO NAZÁRIO ; VALENTE, JÉSSICA SILVINO ; NASCIMENTO-OLIVEIRA, JORDANA INÁCIO ; MARECO, EDSON ASSUNÇÃO ; FERNANDEZ, GEYSSON JAVIER ; DAL-PAI-SILVA, MAELI . Degree of piRNA sharing and Piwi gene expression in the skeletal muscle of Piaractus mesopotamicus (pacu), Colossoma macropomum (tambaqui), and the hybrid tambacu. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY , v. 264, p. 111120, 2022.

• VALDÉS-LÓPEZ, JUAN FELIPE ; FERNANDEZ, GEYSSON J. ; URCUQUI-INCHIMA, SILVIO . Synergistic Effects of Toll-Like Receptor 1/2 and Toll-Like Receptor 3 Signaling Triggering Interleukin 27 Gene Expression in Chikungunya Virus-Infected Macrophages. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY , v. 10, p. 1, 2022.

• FERNANDEZ, GEYSSON JAVIER ; RAMÍREZ-MEJÍA, JULIETA M ; URCUQUI-INCHIMA, SILVIO . Transcriptional and post-transcriptional mechanisms that regulate the genetic program in Zika virus-infected macrophages. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY , v. 153, p. 106312, 2022.

• FERNANDEZ, GEYSSON JAVIER ; RAMÍREZ-MEJÍA, JULIETA M ; URCUQUI-INCHIMA, SILVIO . Vitamin D boosts immune response of macrophages through a regulatory network of microRNAs and mRNAs. JOURNAL OF NUTRITIONAL BIOCHEMISTRY , v. 109, p. 109105, 2022.

• FREIRE, PAULA P. ; CURY, SARAH S. ; LOPES, LETÍCIA O. ; FERNANDEZ, GEYSSON J. ; LIU, JIANMING ; DE MORAES, LEONARDO NAZARIO ; DE OLIVEIRA, GRASIELI ; OLIVEIRA, JAKELINE S. ; DE MORAES, DIOGO ; CABRAL-MARQUES, OTAVIO ; DAL-PAI-SILVA, MAELI ; HU, XIAOYUN ; WANG, DA-ZHI ; CARVALHO, ROBSON F. . Decreased miR-497-5p Suppresses IL-6 Induced Atrophy in Muscle Cells. Cells , v. 10, p. 3527, 2021.

• VALDÉS-LÓPEZ, JUAN FELIPE ; FERNANDEZ, GEYSSON J. ; URCUQUI-INCHIMA, SILVIO . Interleukin 27 as an inducer of antiviral response against chikungunya virus infection in human macrophages. CELLULAR IMMUNOLOGY , v. 367, p. 104411, 2021.

• FERNANDEZ, GEYSSON JAVIER ; CASTILLO, JORGE ANDRÉS ; GIRALDO, DIANA MARCELA ; URCUQUI-INCHIMA, SILVIO . Vitamin D Regulates the Expression of Immune and Stress Response Genes in Dengue Virus-infected Macrophages by Inducing Specific MicroRNAs. MicroRNA , v. 10, p. 240-249, 2021.

• FREIRE, PAULA PACCIELLI ; FERNANDEZ, GEYSSON JAVIER ; MORAES, DIOGO ; CURY, SARAH SANTILONI ; DAL PAI'SILVA, MAELI ; REIS, PATRÍCIA PINTOR ; ROGATTO, SILVIA REGINA ; CARVALHO, ROBSON FRANCISCO . The expression landscape of cachexia-inducing factors in human cancers. Journal of Cachexia, Sarcopenia and Muscle , v. 11, p. 947-961, 2020.

• FREIRE, PAULA PACCIELLI ; FERNANDEZ, GEYSSON JAVIER ; MORAES, DIOGO ; CURY, SARAH SANTILONI ; DAL PAI'SILVA, MAELI ; DOS REIS, PATRÍCIA PINTOR ; ROGATTO, SILVIA REGINA ; CARVALHO, ROBSON FRANCISCO . The authors reply: Comment on -The expression landscape of cachexia-inducing factors in human cancers- by Freire et al.. Journal of Cachexia, Sarcopenia and Muscle , v. 11, p. 1854-1857, 2020.

• FERNANDEZ, GEYSSON JAVIER ; FERREIRA, JUAREZ HENRIQUE ; VECHETTI, IVAN JOSÉ ; DE MORAES, LEONARDO NAZARIO ; CURY, SARAH SANTILONI ; FREIRE, PAULA PACCIELLI ; GUTIÉRREZ, JAYSON ; FERRETTI, RENATO ; DAL-PAI-SILVA, MAELI ; ROGATTO, SILVIA REGINA ; CARVALHO, ROBSON FRANCISCO . MicroRNA-mRNA Co-sequencing Identifies Transcriptional and Post-transcriptional Regulatory Networks Underlying Muscle Wasting in Cancer Cachexia. Frontiers in Genetics , v. 11, p. 1, 2020.

• FERRASI, ADRIANA CAMARGO ; FERNANDEZ, GEYSSON JAVIER ; GROTTO, REJANE MARIA TOMMASINI ; SILVA, GIOVANNI FARIA ; GONCALVES, JOAO ; COSTA, MARINA C. ; ENGUITA, FRANCISCO J. ; PARDINI, MARIA INÊS DE MOURA CAMPOS . New LncRNAs in Chronic Hepatitis C progression: from fibrosis to hepatocellular carcinoma. Scientific Reports , v. 10, p. 1, 2020.

• BARBOSA BATISTA, THIAGO ; Javier fernandez, Geysson ; ALEXANDRE DA SILVA, TIAGO ; MAIA, JÚLIO ; AMARAL DA SILVA, EDVALDO APARECIDO . Transcriptome analysis in osmo-primed tomato seeds with enhanced longevity by heat shock treatment. AoB Plants , v. 12, p. 1, 2020.

• FREIRE, PAULA PACCIELLI ; FERNANDEZ, GEYSSON JAVIER ; CURY, SARAH SANTILONI ; DE MORAES, DIOGO ; OLIVEIRA, JAKELINE SANTOS ; DE OLIVEIRA, GRASIELI ; DAL-PAI-SILVA, MAELI ; DOS REIS, PATRÍCIA PINTOR ; CARVALHO, ROBSON FRANCISCO . The Pathway to Cancer Cachexia: MicroRNA-Regulated Networks in Muscle Wasting Based on Integrative Meta-Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 20, p. 1962, 2019.

• ARBOLEDA, JOHN F. ; FERNANDEZ, GEYSSON J. ; URCUQUI-INCHIMA, SILVIO . Vitamin D-mediated attenuation of miR-155 in human macrophages infected with dengue virus: Implications for the cytokine response. INFECTION GENETICS AND EVOLUTION , v. 69, p. 12-21, 2019.

• SANTILONI CURY, SARAH ; DE MORAES, DIOGO ; PACCIELLI FREIRE, PAULA ; DE OLIVEIRA, GRASIELI ; VENÂNCIO PEREIRA MARQUES, DOUGLAS ; Javier fernandez, Geysson ; DAL-PAI-SILVA, MAELI ; NISHIDA HASIMOTO, ÉRICA ; PINTOR DOS REIS, PATRICIA ; REGINA ROGATTO, SILVIA ; FRANCISCO CARVALHO, ROBSON . Tumor Transcriptome Reveals High Expression of IL-8 in Non-Small Cell Lung Cancer Patients with Low Pectoralis Muscle Area and Reduced Survival. Cancers , v. 11, p. 1251, 2019.

• RIBEIRO, MARIANA A. ; ESTILL, MOLLY S. ; FERNANDEZ, GEYSSON J. ; MORAES, LEONARDO N. ; KRAWETZ, STEPHEN A. ; SCARANO, WELLERSON R. . Integrative transcriptome and microRNome analysis identifies dysregulated pathways in human Sertoli cells exposed to TCDD. TOXICOLOGY , v. 409, p. 112, 2018.

• FERREIRA, JUAREZ H. ; CURY, SARAH S. ; VECHETTI-JÚNIOR, IVAN J. ; FERNANDEZ, GEYSSON J. ; MORAES, LEONARDO N. ; ALVES, CARLOS A. B. ; FREIRE, PAULA P. ; FREITAS, CARLOS E. A. ; DAL-PAI-SILVA, MAELI ; CARVALHO, ROBSON F. . Low-level laser irradiation induces a transcriptional myotube-like profile in C2C12 myoblasts. LASERS IN MEDICAL SCIENCE , v. 33, p. 1673-1683, 2018.

• MORAES, LEONARDO N. ; FERNANDEZ, GEYSSON J. ; VECHETTI-JÚNIOR, IVAN J. ; FREIRE, PAULA P. ; SOUZA, RODRIGO W. A. ; VILLACIS, ROLANDO A. R. ; ROGATTO, SILVIA R. ; REIS, PATRICIA P. ; DAL-PAI-SILVA, MAELI ; CARVALHO, ROBSON F. . Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia. Scientific Reports , v. 7, p. 6998, 2017.

• DIOSA-TORO, MAYRA ; ECHAVARRÍA-CONSUEGRA, LILIANA ; FLIPSE, JACKY ; FERNÁNDEZ, GEYSSON JAVIER ; KLUIVER, JOOST ; VAN DEN BERG, ANKE ; URCUQUI-INCHIMA, SILVIO ; SMIT, JOLANDA M. . MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression. PLoS Neglected Tropical Diseases , v. 11, p. e0005981, 2017.

• FREIRE, PAULA PACCIELLI ; CURY, SARAH SANTILONI ; DE OLIVEIRA, GRASIELI ; FERNANDEZ, GEYSSON JAVIER ; MORAES, LEONARDO NAZARIO ; DA SILVA DURAN, BRUNO OLIVEIRA ; FERREIRA, JUAREZ HENRIQUE ; FUZIWARA, CÉSAR SEIGI ; KIMURA, EDNA TERUKO ; DAL-PAI-SILVA, MAELI ; CARVALHO, ROBSON FRANCISCO . Osteoglycin inhibition by microRNA miR-155 impairs myogenesis. PLoS One , v. 12, p. e0188464, 2017.

• VECHETTI-JUNIOR, I. J. ; BERTAGLIA, R. S. ; FERNANDEZ, G. J. ; DE PAULA, T. G. ; DE SOUZA, R. W. A. ; MORAES, L. N. ; MARECO, E. A. ; DE FREITAS, C. E. A. ; AGUIAR, A. F. ; CARVALHO, R. F. ; DAL-PAI-SILVA, M. . Aerobic Exercise Recovers Disuse-induced Atrophy Through the Stimulus of the LRP130/PGC-1  Complex in Aged Rats. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences , v. 1, p. 1-9, 2015.

• SOUZA, RODRIGO WAGNER ALVES ; FERNANDEZ, GEYSSON J. ; CUNHA, JOAO P. Q. ; PIEDADE, WARLEN PEREIRA ; SOARES, LUANA CAMPOS ; SOUZA, PAULA AIELLO TOMÉ ; DE CAMPOS, DIJON HENRIQUE SALOME ; OKOSHI, KATASHI ; CICOGNA, ANTONIO CARLOS ; DAL-PAI-SILVA, MAELI ; CARVALHO, ROBSON FRANCISCO . Regulation of cardiac microRNAs induced by aerobic exercise training during heart failure. American Journal of Physiology. Heart and Circulatory Physiology , v. 309, p. ajpheart.00941, 2015.

• DURAN, BRUNO OLIVEIRA DA SILVA ; FERNANDEZ, GEYSSON JAVIER ; MARECO, EDSON ASSUNÇÃO ; MORAES, LEONARDO NAZARIO ; SALOMÃO, RONDINELLE ARTUR SIMÕES ; GUTIERREZ DE PAULA, TASSIANA ; SANTOS, VANDER BRUNO ; CARVALHO, ROBSON FRANCISCO ; DAL-PAI-SILVCA, MAELI . Differential microRNA Expression in Fast- and Slow-Twitch Skeletal Muscle of Piaractus mesopotamicus during Growth. Plos One , v. 10, p. e0141967, 2015.

• PENA, V. H. ; Fernandez, G.J. ; GOMEZ, A. M. ; Mejia A ; CANTILLO, O. ; Triana O . High-Resolution Melting (HRM) of the Cytochrome B Gene: A Powerful Approach to Identify Blood-Meal Sources in Chagas Disease Vectors. PLoS Neglected Tropical Diseases (Online) , v. 6, p. e1530, 2012.

• Mejia A ; Fernandez, G.J. ; Montilla M ; Nicholls S ; Triana O . Sensibilidad al benzonidazol de cepas de Trypanosoma cruzi sugiere la circulación de cepas naturalmente resistentes en Colombia. Biomédica (Bogotá) , v. 32, p. 196-205, 2012.

• Mejia A ; Fernandez, G.J. ; PALACIO, L. ; Triana O . Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benznidazole in Trypanosoma cruzi. Parasites & Vectors , v. 4, p. 169-181, 2011.

• Ochoa L ; Fernandez, G.J. ; jimenez L . Development of the axial skeleton during the early ontogeny of pimelodus Sp. (Pisces: Pimelodidade). Boletín Científico Museo de Historia Natural , v. 14, p. 131-134, 2010.

• Muñoz K ; SIERRA, J. ; Fernandez, G.J. ; Alzate F ; Arango G ; Segura C ; Bravo K . Inhibition of a specific antimalarial molecular target and correlation with the activity against p. falciparum as selection criteria of potential antimalarials from natural source. Pharmacologyonline (Salerno) , v. 3, p. 656-661, 2006.

• Fernandez, G.J. ; carvalho R ; REIS, P. P. ; SILVA, M. D. P. ; MARCHAL, K. ; FIERRO, C. ; SANCHEZ, A. ; NOGUEIRA, C. R. . Reconstruction of molecular Networks involved in cytokine induced myotubes atophy by integrating miRNA and mRNA expression profiling. In: EMBO workshop: Molecular mechanisms of muscle growth and wasting in health and disease, 2013, Ascona, switzerland. Molecular mechanisms of muscle growth and wasting in health and disease, 2013.

• SENE, L. B. ; Moraes LN ; Fernandez, G.J. ; GONTIJO, J. ; carvalho R ; PATRICIA, . Micro-RNAs involved in epithelial-to-mesenchymal transition are altered and differentially expressed in adult renal cortex and isolated glomeruli of glomerulusclerosis programmed by low protein diet in uteri. In: microRNA 2012 International Symposium, 2012, Sao Paulo. microRNA 2012 International Symposium, 2012.

• FERREIRA, A. ; Fernandez, G.J. ; SILVA, M. D. P. ; carvalho R . MicroRNA 499 is up regulated in red muscle of adults pacu (Piaractus mesopotamicus). In: microRNA 2012 International Symposium, 2012, Sao Paulo. microRNA 2012 International Symposium, 2012.

• FERNANDEZ, F. ; Fernandez, G.J. ; Moraes LN ; CASTAN, E. ; SILVA, M. D. P. ; carvalho R . Expression of microRNAs mir-1, mir-133 and mir-206 in skeletal muscle of rats with heart failure. In: microRNA 2012 international symposium, 2012, Sao Paulo. microRNA 2012 international symposium, 2012.

• NACHTIGALL, P. ; carvalho R ; Fernandez, G.J. ; MARECO, E. ; MARTINS, C. ; PINHAL, D. . Differential expression of miR-499 between white and red muscle fibers in Nile tilapia fish.. In: microRNA 2012 international symposium, 2012, Sao Paulo. microRNA 2012 international symposium, 2012.

• DELELLA, F. ; MOROZ, A. ; AE, M. ; Fernandez, G.J. ; carvalho R ; DEFFUNE, E. ; FELISBINO, S. L. . miR-16 and miR-125b expression in normal and tumoral prostatic cells treated with finasteride. In: microRNA 2012 international symposium, 2012, Sao Paulo. microRNA 2012 international symposium, 2012.

• CARVALHO, A. J. ; Fernandez, G.J. ; Moraes LN ; CASTAN, E. ; SILVA, M. D. P. ; carvalho R . Down-regulation of micro-RNAs -208b and -499 in slow-to-fast phenotype transition and atrophy of rat skeletal muscle with heart failure. In: microRNA 2012 international symposium, 2012, Sao Paulo. microRNA 2012 international symposium, 2012.

• Fernandez, G.J. ; carvalho R ; SILVA, M. D. P. ; REIS, P. P. ; NOGUEIRA, C. R. ; CONDE, S. J. . Time course of atrogenes MurF1 and MAFbx mRNA expression during skeletal muscle atrophy in C2C12 cells. In: Cancer cachexia conference, 2012, Boston. Journal of Cachexia, Sarcopenia and Muscle. Germany: Springer, 2012. v. 3. p. 288-289.

• PENA, V. H. ; Fernandez, G.J. ; CANTILLO, O. ; GOMEZ, A. M. ; Mejia A ; Triana O . High resolution melting del gen citocromo B, una poderosa herramienta para identificar fuentes alimenticias de vectores de la enfermedad de Chagas (Reduviidae: Triatominae). In: XX Congreso Latinoamericano de Parasitologia, 2011, Bogota. Biomédica (Bogotá). Colombia: Biomedica, 2011. v. 31. p. 58-58.

• Fernandez, G.J. ; Mejia A ; Triana O . Sensibilidad al benznidazol ce cepas colombianas de Trypanosoma cruzi y analisis de la expresión de genes involucrados en la resistencia a la droga. In: XLV CONGRESO NACIONAL DE CIENCIAS BIOLÓGICAS, 2010, Armenia. MEMORIAS XLV CONGRESO NACIONAL DE CIENCIAS BIOLÓGICAS. Armenia: revista asociacion colombiana de ciencias biologicas, 2010. v. 22. p. 58-59.

• Ochoa L ; Fernandez, G.J. ; jimenez L ; MACRANDER, J. ; Orti G . Identificación genética de algunas especies de peces migratorias de la cuenca del río magdalena. In: : X Simposio Colombiano de Ictiología, II Encuentro Colombo-Venezolano de Ictiólogos y I Encuentro Suramericano de Ictiólogos, 2009, Medellin. Actualidades biologicas. Medellin: Actualidades biologicas, 2009. v. 31. p. 114.

• Fernandez, G.J. ; BUILES, J. ; Arango A ; jimenez L . Evaluación de la variabilidad genética y estructura poblacional del bocachico, Prochilodus magdalenae (Steindachner, 1878) (pisces: prochilodontidae) en la cuenca del río Cauca, Colombia. In: X Simposio Colombiano de Ictiología, II Encuentro Colombo-Venezolano de Ictiólogos y I Encuentro Suramericano de Ictiólogos, 2009, medellin. Actualidades biologicas. Medellin: Actualidades biologicas, 2009. v. 31. p. 134.

• Ramirez M ; Hurtado J ; Fernandez, G.J. . Análisis morfométrico de la conformación del labelo en Epidendrum xanthium Lindl. (Orchidaceae). In: IV Congreso de Botánica, 2007, Medellin. Actualidades Biologicas. Medellin, 2007. v. 29. p. 180-180.

• Fernandez, G.J. ; Garcia P ; Mejia A ; Montilla M ; Nicholls S ; Triana O . SENSIBILIDAD AL BENZNIDAZOL DE CEPAS COLOMBIANAS DE Trypanosoma cruzi AISLADAS DE HUMANOS, RESERVORIOS Y VECTORES. In: XII Congreso colombiano de parasitología y medicina tropical, 2007, Ibague. Biomédica (Bogotá). Bogota: Biomedica, 2007. v. 27. p. 110.

• Fernandez, G.J. ; Mejia A ; Triana O . Sensibilidad al Beznidazol de cepas colombianas de Trypanosoma cruzi y analisis de la expresion de genes involucrados en la resistencia a drogas. 2010. (Apresentação de Trabalho/Congresso).

• Fernandez, G.J. . Topicos en biologia. 2011. .

Projetos de pesquisa

• 2018 - Atual

  Evaluación del papel de la vitamina D en la expresión de receptores tipo Toll, citoquinas y microRNA en respuesta a la infección por los virus Chikungunya y Zika, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Geysson Javier Fernandez Garcia - Integrante / silvio urcuqui inchima - Coordenador.

• 2016 - Atual

  Mecanismos moleculares subjacentes à indução e repressão da expressão gênica mediada pelo TNF na caquexia, Descrição: As citocinas pró-inflamatórias, tais como o Fator de Necrose Tumoral-alfa (TNF), tem sido implicado na patogênese de atrofia do músculo esquelético na caquexia, uma síndrome metabólica comumente associados com muitas doenças inflamatórias sistémicas crónicas tais como o câncer e o SIDA. Embora o aumento da regulação dos níveis de mRNA em resposta à sinalização de TNF tem sido extensivamente estudado no contexto da ativação imunitária, tal como nos macrófagos, os mecanismos que controlam o programa de repressão genética, o que é de particular relevância nas células do músculo esquelético, são ainda pouco compreendidos. Considerando que os ativadores transcricionais, mais proeminentemente NFºB são conhecidos para controlar a ativação do gene, os mecanismos para a repressão do gene podem não envolvem apenas proteínas de ligação de ADN que regulam a iniciação do mRNA, mas também os mecanismos que controlam a decomposição. Aqui propomos estudar a nível de todo o genoma, o efeito da sinalização pelo TNF em eventos metabólicos do RNA, que regulam programas de indução e repressão de genes em células musculares. Refinadas conjuntos de dados irá distinguir entre a síntese de mRNA e degradação mRNA, e uma abordagem de modelagem matemática será utilizado para obter parâmetros cinéticos e identificar os principais mecanismos de controle para cada uma das centenas de genes afetados. Este conhecimento vai ajudar a lançar luz sobre como a interação entre a sinalização pelo TNF e metabolismo do RNA leva a um programa de expressão de genes relacionados à atrofia muscular na caquexia associada ao câncer. O projeto também tem um objetivo metodológico, que consiste na criação de um fluxo de trabalho experimental e analítico para o perfil dinâmico da expressão gênica e do metabolismo do RNA em perda de massa muscular.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Geysson Javier Fernandez Garcia - Coordenador / robson carvalho - Integrante / alexander hoffmann - Integrante.

• 2014 - Atual

  Multilayer-omics analysis of cancer cachexia: integrative approach to identify biomarkers and drug targets, Descrição: ancer cachexia is a syndrome characterized by the severe wasting of skeletal muscle tissue; that is estimated to affect more than 50% of all cancer patients and results in lower quality of life due to compromised fatigue, weakness, immune function, insulin resistance and poor tolerance and response to chemotherapy. Remarkably, approximately 30% of cancer-related deaths are estimated as a result of cachexia. There is no effective targeted therapy for muscle wasting in cancer cachexia. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecular interactions, in this way Omic studies have helped clarify the impact of regulatory elements on disease. The feasibility of genome-wide analysis of Omics marks at nucleotide resolution using Next Generation Sequencing has already been demonstrated in the ENCODE projects, as well as the TCGA consortium. Considering this, our hypothesis is that comparison of muscles omics profiles from healthy and cancer cachexia will reveal disease novel specific signatures and a better understanding of the cellular signaling mechanisms and gene regulation in muscle, which will lead to the identification of candidate genes, involved in the pathogenesis, and may be helpful in finding biomarkers and drug targets.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Geysson Javier Fernandez Garcia - Integrante / CARVALHO, R. F. - Coordenador.

• 2013 - Atual

  Identifying miRNAs with cellular antiviral activity in response to infection by the dengue virus, Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) / Doutorado: (1) . , Integrantes: Geysson Javier Fernandez Garcia - Coordenador / silvio urcuqui inchima - Integrante / JOLANDA M SMIT - Integrante / MAYRA DIOSA TORO - Integrante.

• 2011 - 2013

  Genomic Profiling of Messenger RNAs and MicroRNAs in muscle cells treated in vitro with TNF-α and IFN-γ, Descrição: The skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such a sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These diseases may be accompanied by a complex metabolic syndrome characterized by muscle wasting, denominated cachexia. The molecular pathways responsible for cachexia are not completely understood, however, evidence suggest that pro-inflammatory cytokines like Tumor Necrosis Factor (TNF)-α and Interferon (INF)-γ have a key role in molecular pathways related to loss of function and muscle mass. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecules, such as microRNAs; these RNA molecules encoded by the genome regulate the function of skeletal muscle during development and various muscle diseases. MicroRNAs orchestrate common pathways or biological function, this unique feature gives rise as an effective tool for determining the pathways involved in specific diseases or biological processes. The hypothesis of this work is that the muscle atrophy induced by TNF-α and INF-γ has a microRNAs expression profile that will allow the identification of regulatory networks and molecular pathways.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) / Mestrado acadêmico: (1) . , Integrantes: Geysson Javier Fernandez Garcia - Coordenador / robson carvalho - Integrante / Maeli Dal Pai Silva - Integrante / Patricia Pintor dos Reis - Integrante.

• 2010 - 2012

  High Resolution Melting (HRM) of Cythochrome B gene a powerful approach to identify bloos meal sources in Triatominae, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Geysson Javier Fernandez Garcia - Integrante / Omar triana - Coordenador.

• 2008 - 2012

  Evaluation of the expression of candidate genes for resistance to benznidazole Trypanosoma cruzi I and II, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Geysson Javier Fernandez Garcia - Integrante / Omar triana - Coordenador.

• 2008 - 2012

  Benznidazole sensitivity of Trypanosoma cruzi Colombian strains isolated from humans, reservoirs and vectors, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Geysson Javier Fernandez Garcia - Integrante / Omar triana - Coordenador.

• 2007 - 2012

  Population genetic study of Bocachico, Prochilodus magdalenae (Steindachner 1878) in the river Cauca, Colombia with microsatellite markers., Situação: Concluído; Natureza: Pesquisa. , Integrantes: Geysson Javier Fernandez Garcia - Coordenador.

• 2006 - 2007

  Aromatic monoterpene isoprenoids synthesis and correlation between its antimalarial activity and inhibition of heme detoxification processes., Situação: Concluído; Natureza: Pesquisa. , Integrantes: Geysson Javier Fernandez Garcia - Coordenador., Financiador(es): Departamento Administrativo de Ciencia, Tecnología e Innovación - Bolsa.

• 2005 - 2007

  Evaluation of the antimalarial activity on Plasmodium falciparum and inhibitory activity ferrriprotoporfirina IX biomineralization of plant extracts of the Euphorbiaceae family, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Geysson Javier Fernandez Garcia - Coordenador.

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