Marcelo Gialluisi Bonini

Professor Visitante Especial do Ciências se Fronteiras para o Programa de Pós-Graduação em Biociências Aplicadas à Farmácia/Universidade Estadual de Maringá/PR- início: 07/11/2013; duração: 3 anos Professor Associado (Associate Professor) da Universidade de Illinois em Chicago. Meu programa de pesquisa tem-se focado no estudo dos mecanismos e consequencias funcionais da sinalização celular desempenhada por espécies reativas de oxigênio e nitrogenio. Especificamente nossos projetos estão focados em duas grandes areas a seguir: Mecanismos de ativação da resposta hipoxica em células cancerosas: A ativação da resposta hipoxica permite que células normais sobrevivam a interrupção momentânea no suprimento de oxigênio. O retorno do suprimento de oxigênio instantaneamente reverte a ativação da resposta hipoxica permitindo as células sentir a presença e utilizar o oxigênio para geração de energia através da respiração. Diferente de células normais células cancerosas apresentam ativação da resposta hipoxica mesmo quando o suprimento de oxigênio encontra-se normal. A ativação da resposta hipoxica em cancer esta associada a vascularização, progressão, e metastase do tumor e portanto pode ser um alvo terapêutico importante. Nossos estudos visam compreender os mecanismos pelos quais os fatores de transcrição induzidos por hipoxia são ativados em cancer com foco na hipótese que mudanças no metabolismo mitocondrial de espécies reativas de oxigênio ativam o fator induzido por hipoxia 2-alpha (HIF2-alpha) levando a formação de células tronco tumorais Mecanismos de iniciação da inflamação em macrofagos - Macrofagos são células da imunidade inata responsáveis pela iniciação da resposta inflamatoria desencadeada por patógenos. A ativação da resposta inflamatória depende do fator de transcrição "nuclear factor kappa B" ou NF(kappa)B. O curso, intensidade e duração das inflamações são regulados pelo NF(kappa)B e portanto a supressão de sua atividade leva a uma potente ação anti-inflamatoria. Nossos estudos indicaram que o oxido nítrico (uma das espécies reativas de oxigênio) reage e inibe a enzima SOCS1 (suppressor of cytokine signaling-1) levando a ativação prolongada e intensificada do NF(kappa)B. Assim nossos estudos estabeleceram que EROS regulam a atividade do NF(kappa)B através da supressão da atividade da SOCS1.

Informações coletadas do Lattes em 22/10/2019

Acadêmico

Seção coletada automaticamente pelo Escavador

Formação acadêmica

Doutorado em Bioquímica

1999 - 2003

Instituto de Química da Universidade de São Paulo
Título: Produção e alvos biológicos de dióxido de nitrogênio e anion radical carbonato produção a partir de peroxinitrito-dióxido de carbono superóxido dismutase e xantina oxidase
Orientador: Ohara Augusto
Bolsista do(a): Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP, Brasil.

Graduação em Química

1995 - 1998

Instituto de Química da Universidade de São Paulo

Seção coletada automaticamente pelo Escavador

Pós-doutorado

2004 - 2007

Pós-Doutorado. , National Institute Of Health, NIH, Estados Unidos. , Bolsista do(a): National Institutes of Health, NIH/NIEHS, Estados Unidos.

Seção coletada automaticamente pelo Escavador

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Espanhol

Compreende Bem, Fala Razoavelmente, Lê Bem, Escreve Pouco.

Francês

Compreende Bem, Fala Bem, Lê Bem, Escreve Razoavelmente.

Seção coletada automaticamente pelo Escavador

Áreas de atuação

    Grande área: Ciências Biológicas / Área: Bioquímica.

    Grande área: Ciências da Saúde / Área: Farmácia / Subárea: Análises Toxicológicas.

    Grande área: Ciências Biológicas / Área: Farmacologia.

Seção coletada automaticamente pelo Escavador

Organização de eventos

Bonini, M. G. . 20th Annual Meeting of the Society for Free Radical Biology and Medicine. 2013. (Congresso).

Bonini, Marcelo G. . Professional Development Session - SFRBM 2012. 2012. (Outro).

Seção coletada automaticamente pelo Escavador

Participação em eventos

19 th annual meeting of the SFRBM. Plenary session chair - Cellular Redox Sensors. 2012. (Congresso).

51st Annual Meeting of the Society of Toxicology.SOT Meeting 2012. 2012. (Encontro).

ASBMB Simposium: Mitochondria energy, signaling and homeostasis.Mitochondrial mechanisms of AMPK regulation in cancer. 2012. (Simpósio).

III Simposio (PBF) - Universidade Estadual de Maringa.From peroxynitrite to MnSOD: a radical journey. 2012. (Simpósio).

American Heart Association - Scientific Sessions.c-Src Tyrosine Kinase Mediates the Effect of Mitochondrial Oxidative Stress on Gap Junctional Remodeling and Ventricular Tachycardia. 2011. (Encontro).

EPR 2010. MnSOD peroxidase activity as a novel mitochondrial redox modulator. 2010. (Congresso).

15th Annual Meeting of the Society for Free Radical Biology and Medicine. Nitroglycerin-induced vasodilation is dependent on signal transduction pathways. 2008. (Congresso).

10th conference of the international union of biochemistry and molecular biology (IUBMB). Young Scientist Forum. 2007. (Congresso).

14th annual Meeting of the SFRBM. Session Chair. 2007. (Congresso).

XIII Meeting of the Society for Free Radical Biology and Medicine. Immunospin-trapping based protein free radical imaging in sub-cellular structures. 2006. (Congresso).

8th Spin trapping meeting. 8th SPIN TRAPPING MEETING. 2005. (Congresso).

XII Annual Meeting of the Society for Free Radical Biology and Medicine. 12th Annual Meeting of the Society for Free Radical Biology and Medicine. 2005. (Congresso).

11 th Annual Meeting of the Society for Free Radical Biology and Medicine. 11 th Annual Meeting of the Society for Free Radical Biology and Medicine. 2004. (Congresso).

10 th Annual Meeting of the Society for Free Radical Biology and Medicine. 10 th Annual Meeting of the Society for Free Radical Biology and Medicine. 2003. (Congresso).

XXXII reuniao anual da SBBq. XXXII Reuniao anual da SBBq. 2003. (Congresso).

7 th International Symposium on Spin Trapping.7th International Symposium on Spin Trapping. 2002. (Simpósio).

7th Annaul Meeting of the Oxygen Society. 7th Annual Meeting of the Oxygen Society. 2000. (Congresso).

First Meeting of the South American Group for Free Radical Research. First Meeting of the South American Group for Free Radical Research. 2000. (Congresso).

XXIX Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular. XXIX Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular. 2000. (Congresso).

9th Biennial Meeting of the International Society for Free Radical Research. IX Biennial Meeting of the international society for free radical research. 1998. (Congresso).

Seção coletada automaticamente pelo Escavador

Participação em bancas

Aluno: Bianca Altrão Ratti

BONINI, M. G.; LAUTSCHENLAGEN, S. O. S.. A suscetibilidade de candidíase vulvovaginal recorrente por C. albicans envolve uma diminuição no mecanismo de defesa imunológico desencadeado por neutrófilos,. 2012. Dissertação (Mestrado em Biociências Aplicadas à Farmácia) - Universidade Estadual de Maringá.

Aluno: David McMillan

Bonini, M. G.; FREITAG, N.. Thesis Comittee. 2012 - University of Illinois.

Aluno: Jessica Lowry

Bonini, M. G.; SKIDGEL, R.. Thesis Comittee. 2012 - University of Illinois.

Aluno: Kelly Gay

Bonini, M. G.; WALDEN, W.. Thesis Comittee. 2011 - University of Illinois.

Aluno: Vaishali Sinha

BONINI, M. PhD thesis defense committee. 2010 - University of Illinois at Chicago.

Aluno: Zheng Ding

Bonini, M. G.; HOGG, N.. Thesis Comittee. 2010 - University of Illinois.

Aluno: Farnaz Bakhshi

Bonini, Marcelo G.. Caveolin-1 S-nitrosation and degradation in pulmonary hypertension. 2011. Exame de qualificação (Doutorando em pharmacology) - University of Illinois.

Aluno: Tracy Thennes

Bonini, Marcelo G.. Role of Focal Adhesion Kinase in endothelial junctional regulation during sepsis. 2011. Exame de qualificação (Doutorando em pharmacology) - University of Illinois.

Seção coletada automaticamente pelo Escavador

Comissão julgadora das bancas

Maria Teresa Machini

MONTEIRO, H. P.;MIRANDA, M.T.M.POLITI, M. J.. Produção e alvos biológicos de dióxido de nitrogênio e anion radical carbonanto. 2002. Exame de qualificação (Doutorando em BIOQUÍMICA (IQ-USP)) - Universidade de São Paulo.

Mario Jose Politi

POLITI, M. J.; MONTEIRO, Hugo Pequeno; MIRANDA, Maria Teresa Machini de. Mecanismos de Oxidação de Biomoléculas por Peroxinitrito. 2002. Exame de qualificação (Doutorando em Bioquimica) - Instituto de Quimica Usp.

Paolo Di Mascio

DI MASCIO, P.; OLIVEIRA, C. C.;BECHARA, E. J. H.. Produção e alvos biológicos de dióxido de nitrogênio e anion radical carbonato produção a partir de peroxinitrito-dióxido de carbono superóxido dismutase e xantina oxidase. 2001. Exame de qualificação (Doutorando em Bioquímica) - Instituto de Química -USP.

Seção coletada automaticamente pelo Escavador

Orientou

Bianca Altrão Ratti

ROLE OF MITOCHONDRIA-REACTIVE OXYGEN SPECIES IN THE HPV-INDUCED CELLULAR MALIGNANT REPROGRAMMING; ; Início: 2013; Tese (Doutorado em Biociências Aplicadas à Farmácia) - Universidade Estadual de Maringá, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; (Orientador);

Peter Hart

Role of Caveolin-1 in the regulation of cancer cell metabolism; Início: 2012; Tese (Doutorado em pharmacology) - University of Illinois, National Institutes of Health; (Orientador);

Andre Luelsdorf Abreu

Impact of MnSOD overexpression on Glut4 membrane accumulation in cancer cells; Início: 2012; Tese (Doutorado em Biociências Aplicadas à Farmácia) - Universidade Estadual de Maringá, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; (Coorientador);

Tracy Thennes

Role of Focal Adhesion Kinase in LPS-induced endothelial barrier disruption; Início: 2011; Tese (Doutorado em Doctorate in Science) - University of Illinois at Chicago; (Coorientador);

Farnaz Bakhshi

Role of caveolin activation c-Src induced eNOS inhibitory feedback loop; Início: 2010; Tese (Doutorado em Doctorate in Science) - University of Illinois at Chicago; (Coorientador);

Alyssa Master

Início: 2013; University of Illinois - System, Department of Health and Human Services;

Uzma Saqib

Início: 2011; University of Illinois at Chicago;

Mirza Saqib Baig

Início: 2011; University of Illinois at Chicago;

Nathan Sieracki

Início: 2011; University of Illinois;

Micaela vargas

Início: 2010; University of Illinois at Chicago;

André Luelsdorf Pimenta de Abreu

MnSOD expression and the undifferentiation to stemness in HPV-induced cervical cancer; 2016; Tese (Doutorado em Biociências Aplicadas à Farmácia) - Universidade Estadual de Maringá, Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coorientador: Marcelo Gialluisi Bonini;

Bianca Altrão Ratti

Metformin-induced breast cancer cell death involves deficit in NADH/NAD+ recycling and reductive stress; 2016; Tese (Doutorado em Biociências Aplicadas à Farmácia) - Universidade Estadual de Maringá, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Orientador: Marcelo Gialluisi Bonini;

Peter C

Hart; Manganese superoxide dismutase (MnSOD) a driver of the metabolism critical for breast cancer progression; 2015; Tese (Doutorado em Pathology) - University of Illinois,; Orientador: Marcelo Gialluisi Bonini;

Sofia Zaichik

2015; University of Illinois,; Marcelo Gialluisi Bonini;

Mirza Saqib Baig

2014; University of Illinois,; Marcelo Gialluisi Bonini;

Kristine Ansenberger-Fricano

2013; University of Illinois - System, Department of Health and Human Services; Marcelo Gialluisi Bonini;

Benjamin N

Gantner; 2011; University of Illinois,; Marcelo Gialluisi Bonini;

Colt Melton

2011; University of Illinois,; Marcelo Gialluisi Bonini;

Seção coletada automaticamente pelo Escavador

Foi orientado por

Ohara Augusto

Produção e alvos biológicos de dióxido de nitrogênio e anion radical carbonanto; 2004; Tese (Doutorado em Bioquímica) - Instituto de Química-Universidade de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo; Orientador: Ohara Augusto;

Seção coletada automaticamente pelo Escavador

Produções bibliográficas

  • FETTIPLACE, MICHAEL R. ; KOWAL, KATARZYNA ; RIPPER, RICHARD ; YOUNG, ALEXANDRIA ; LIS, KINGA ; RUBINSTEIN, ISRAEL ; BONINI, MARCELO ; MINSHALL, RICHARD ; WEINBERG, GUY . Insulin Signaling in Bupivacaine-induced Cardiac Toxicity. Anesthesiology (Philadelphia) , v. 124, p. 428-442, 2016.

  • TAETZSCH, THOMAS ; LEVESQUE, SHANNON ; MCGRAW, CONSTANCE ; BROOKINS, SAVANNAH ; LUQA, RAFY ; Bonini, Marcelo G. ; Mason, Ronald P. ; OH, UNSONG ; BLOCK, MICHELLE L. . Redox regulation of NF-κB p50 and M1 polarization in microglia. GLIA (New York, N.Y. : Print) , v. 63, p. 423-440, 2015.

  • TANG, HAIYANG ; CHEN, JIWANG ; FRAIDENBURG, DUSTIN R. ; SONG, SHANSHAN ; SYSOL, JUSTIN R. ; DRENNAN, ABIGAIL R. ; OFFERMANNS, STEFAN ; YE, RICHARD D. ; Bonini, Marcelo G. ; Minshall, Richard D. ; GARCIA, JOE G. N. ; MACHADO, ROBERTO F. ; MAKINO, AYAKO ; YUAN, JASON X.-J. . Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. American Journal of Physiology. Lung Cellular and Molecular Physiology , v. 308, p. L208-L220, 2015.

  • HART, PETER C. ; Mao, Mao ; DE ABREU, ANDRE LUELSDORF P. ; Ansenberger-Fricano, Kristine ; EKOUE, DEDE N. ; GANINI, DOUGLAS ; KAJDACSY-BALLA, ANDRE ; DIAMOND, ALAN M. ; Minshall, Richard D. ; CONSOLARO, MARCIA E. L. ; Santos, Janine H. ; Bonini, Marcelo G. . MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer. Nature Communications , v. 6, p. 6053, 2015.

  • SCHLÄPFER, MARTIN ; PIEGELER, TOBIAS ; DULL, RANDAL O ; SCHWARTZ, DAVID E ; Mao, Mao ; Bonini, Marcelo G ; Z?GRAGGEN, BIRGIT ; BECK-SCHIMMER, BEATRICE ; MINSHALL, RICHARD D . Propofol increases morbidity and mortality in a rat model of sepsis. Critical Care (London. Print) , v. 19, p. 45, 2015.

  • BAIG, M. S. ; ZAICHICK, S. V. ; Mao, M. ; DE ABREU, A. L. ; Bakhshi, F. R. ; HART, P. C. ; SAQIB, U. ; DENG, J. ; CHATTERJEE, S. ; BLOCK, M. L. ; Vogel, S. M. ; Malik, A. B. ; CONSOLARO, M. E. L. ; CHRISTMAN, J. W. ; Minshall, R. D. ; GANTNER, B. N. ; BONINI, M. G. . NOS1-derived nitric oxide promotes NF- B transcriptional activity through inhibition of suppressor of cytokine signaling-1. The Journal of Experimental Medicine , v. open, p. 7053, 2015.

  • HECQUET, C. M. ; ZHANG, M. ; MITTAL, M. ; Vogel, S. M. ; DI, A. ; GAO, X. ; BONINI, M. G. ; Malik, A. B. . Cooperative Interaction of trp Melastatin Channel Transient Receptor Potential (TRPM2) With Its Splice Variant TRPM2 Short Variant Is Essential for Endothelial Cell Apoptosis. Circulation Research , v. 114, p. 469-479, 2014.

  • PIEGELER, TOBIAS ; VOTTA-VELIS, E. GINA ; BAKHSHI, FARNAZ R. ; Mao, Mao ; CARNEGIE, GRAEME ; Bonini, Marcelo G. ; SCHWARTZ, DAVID E. ; BORGEAT, ALAIN ; BECK-SCHIMMER, BEATRICE ; Minshall, Richard D. . Endothelial Barrier Protection by Local Anesthetics. Anesthesiology (Philadelphia) , v. 120, p. 1414-1428, 2014.

  • GONG, H. ; GAO, X. ; FENG, S. ; Siddiqui, M. R. ; GARCIA, A. ; BONINI, M. G. ; KOMAROVA, Y. ; Vogel, S. M. ; MEHTA, D. ; Malik, A. B. . Evidence of a common mechanism of disassembly of adherens junctions through G 13 targeting of VE-cadherin. The Journal of Experimental Medicine , v. 211, p. 579-591, 2014.

  • YANG, KAI-CHIEN ; Bonini, Marcelo G. ; Dudley, Samuel C. . Mitochondria and arrhythmias. Free Radical Biology & Medicine , v. 71, p. 351-361, 2014.

  • Bonini, Marcelo G ; MALIK, ASRAR B . Regulating the regulator of ROS production. Cell Research , v. 24, p. 908-909, 2014.

  • GIMENES, FABRÍCIA ; MEDINA, FABIANA SOARES ; ABREU, ANDRÉ LUELSDORF PIMENTA DE ; IRIE, MARY MAYUMI TAGUTI ; ESQUIÇATI, ISIS BARONI ; MALAGUTTI, NATÁLIA ; VASCONCELLOS, VINÍCIUS RODRIGO BULLA ; DISCACCIATI, MICHELE GARCIA ; BONINI, MARCELO GIALLUISI ; MARIA-ENGLER, SILVYA STUCHI ; CONSOLARO, MARCIA EDILAINE LOPES . Sensitive Simultaneous Detection of Seven Sexually Transmitted Agents in Semen by Multiplex-PCR and of HPV by Single PCR. Plos One , v. 9, p. e98862, 2014.

  • YANG, K.-C. ; RUTLEDGE, C. A. ; Mao, M. ; Bakhshi, F. R. ; XIE, A. ; LIU, H. ; BONINI, M. G. ; PATEL, H. H. ; Minshall, R. D. ; DUDLEY, S. C. . Caveolin-1 Modulates Cardiac Gap Junction Homeostasis and Arrhythmogenecity by Regulating cSrc Tyrosine Kinase. Circulation. Arrhythmia and Electrophysiology , v. 7, p. 701-710, 2014.

  • BERA, S. ; WEINBERG, F. ; EKOUE, D. N. ; ANSENBERGER-FRICANO, K. ; Mao, M. ; BONINI, M. G. ; DIAMOND, A. M. . Natural Allelic Variations in Glutathione Peroxidase-1 Affect Its Subcellular Localization and Function. Cancer Research (Chicago, Ill.) , v. 74, p. 5118-5126, 2014.

  • Mao, Mao ; VARADARAJAN, SUDHAHAR ; Fukai, Tohru ; BAKHSHI, FARNAZ R. ; CHERNAYA, OLGA ; Dudley, Samuel C. ; Minshall, Richard D. ; Bonini, Marcelo G. . Nitroglycerin Tolerance in Caveolin-1 Deficient Mice. Plos One , v. 9, p. e104101, 2014.

  • GIMENES, FABRÍCIA ; SOUZA, RAQUEL P. ; BENTO, JAQUELINE C. ; TEIXEIRA, JORGE J. V. ; MARIA-ENGLER, SILVYA S. ; Bonini, Marcelo G. ; CONSOLARO, MARCIA E. L. . Male infertility: a public health issue caused by sexually transmitted pathogens. Nature Reviews. Urology (Print) , v. 11, p. 672-687, 2014.

  • GIMENES, FABRÍCIA ; TEIXEIRA, JORGE JUAREZ VIEIRA ; DE ABREU, ANDRÉ LUELSDORF PIMENTA ; SOUZA, RAQUEL PANTAROTTO ; PEREIRA, MONALISA WOLSKI ; DA SILVA, VÂNIA RAMOS SELA ; BÔER, CINTHIA GANDOLFI ; MARIA-ENGLER, SILVYA STUCHI ; BONINI, MARCELO GIALLUISI ; BORELLI, SUELI DONIZETE ; CONSOLARO, MÁRCIA EDILAINE LOPES . Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: A candidate molecule for therapeutic intervention and prognostic biomarker?. Biochimica et Biophysica Acta, CR. Reviews on Cancer , v. 1846, p. 576-589, 2014.

  • Bonini, Marcelo G. ; CONSOLARO, MARCIA E. L. ; HART, PETER C. ; Mao, Mao ; DE ABREU, ANDRE LUELSDORF PIMENTA ; MASTER, ALYSSA M. . Redox control of enzymatic functions: The electronics of life's circuitry. IUBMB Life (London. Print) , v. 66, p. n/a-n/a, 2014.

  • SIERACKI, NATHAN A. ; GANTNER, BENJAMIN N. ; Mao, Mao ; HORNER, JOHN H. ; YE, RICHARD D. ; Malik, Asrar B. ; NEWCOMB, MARTIN E. ; Bonini, Marcelo G. . Bioluminescent detection of peroxynitrite with a boronic acid-caged luciferin. Free Radical Biology & Medicine , v. X, p. XX, 2013.

  • SOVARI, A. A. ; RUTLEDGE, C. A. ; JEONG, E.-M. ; DOLMATOVA, E. ; ARASU, D. ; LIU, H. ; VAHDANI, N. ; GU, L. ; ZANDIEH, S. ; XIAO, L. ; BONINI, M. G. ; DUFFY, H. S. ; DUDLEY, S. C. . Mitochondria Oxidative Stress, Connexin43 Remodeling, and Sudden Arrhythmic Death. Circulation. Arrhythmia and Electrophysiology , v. X, p. XXX, 2013.

  • Dallas, Shannon ; BLOCK, MICHELLE L ; THOMPSON, DEBORAH M ; Bonini, Marcelo G ; RONALDSON, PATRICK T ; BENDAYAN, REINA ; MILLER, DAVID S . Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment. Journal of Neuroinflammation , v. 10, p. 58, 2013.

  • TOWNER, RHEAL A. ; SMITH, NATALIYA ; SAUNDERS, DEBRA ; LUPU, FLOREA ; SILASI-MANSAT, ROBERT ; WEST, MELINDA ; RAMIREZ, DARIO C. ; GOMEZ-MEJIBA, SANDRA E. ; Bonini, Marcelo G. ; Mason, Ronald P. ; Ehrenshaft, Marilyn ; HENSLEY, KENNETH . In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis. Free Radical Biology & Medicine , v. 63, p. 351-360, 2013.

  • SCHMIDT, T. T. ; TAUSEEF, M. ; YUE, L. ; BONINI, M. G. ; GOTHERT, J. ; SHEN, T.-L. ; GUAN, J.-L. ; PREDESCU, S. A. ; SADIKOT, R. T. ; MEHTA, D. . Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities. American Journal of Physiology. Lung Cellular and Molecular Physiology , v. 305, p. 1, 2013.

  • HOBBS, G. AARON ; Bonini, Marcelo G. ; Gunawardena, Harsha P. ; Chen, Xian ; Campbell, Sharon L. . Glutathiolated Ras: Characterization and implications for Ras activation. Free Radical Biology & Medicine , v. 57, p. 221-229, 2013.

  • Ansenberger-Fricano, Kristine ; GANINI, DOUGLAS ; Mao, Mao ; Chatterjee, Saurabh ; Dallas, Shannon ; Mason, Ronald P. ; Stadler, Krisztian ; Santos, Janine H. ; Bonini, Marcelo G. . The peroxidase activity of mitochondrial superoxide dismutase. Free Radical Biology & Medicine , v. 54, p. 116-124, 2013.

  • SOUZA, RAQUEL P ; GIMENES, FABRÍCIA ; DE ABREU, ANDRÉ LP ; ROCHA-BRISCHILIARI, SHEILA C ; DE CARVALHO, MARIA DB ; FERREIRA, ÉRIKA C ; Bonini, Marcelo G ; PELLOSO, SANDRA M ; CONSOLARO, MARCIA EL . Differences in the mutation of the p53 gene in exons 6 and 7 in cervical samples from HIV- and HPV-infected women. Infectious Agents and Cancer , v. 8, p. 38, 2013.

  • SOUZA, R. P. ; DE ABREU, A. L. P. ; FERREIRA, E. C. ; ROCHA-BRISCHILIARI, S. C. ; DE B. CARVALHO, M. D. ; PELLOSO, S. M. ; BONINI, M. G. ; GIMENES, F. ; CONSOLARO, M. E. L. . Simultaneous Detection of Seven Sexually Transmitted Agents in Human Immunodeficiency Virus-Infected Brazilian Women by Multiplex Polymerase Chain Reaction. The American Journal of Tropical Medicine and Hygiene , v. 89, p. 1199-1205, 2013.

  • BAKHSHI, FARNAZ R. ; Mao, Mao ; SHAJAHAN, AYESHA N. ; PIEGELER, TOBIAS ; CHEN, ZHENLONG ; CHERNAYA, OLGA ; SHARMA, TIFFANY ; ELLIOTT, W. MARK ; SZULCEK, ROBERT ; BOGAARD, HARM JAN ; COMHAIR, SUZY ; ERZURUM, SERPIL ; VAN NIEUW AMERONGEN, GEERTEN P. ; Bonini, Marcelo G. ; Minshall, Richard D. . Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulmonary Circulation , v. 3, p. 816-830, 2013.

  • BONINI, M. G. ; Kadiiska, M. B. ; Ruggiero, C. ; Cleland, E. ; Wicks, S. ; STADLER, K. . Thiazolidinedione Treatment Decreases Oxidative Stress in Spontaneously Hypertensive Heart Failure Rats Through Attenuation of Inducible Nitric Oxide Synthase-Mediated Lipid Radical Formation. Diabetes (New York, N.Y.) , v. 61, p. 586-596, 2012.

  • Mao, Mao ; Sudhahar, Varadarajan ; Ansenberger-Fricano, Kristine ; Fernandes, Denise C. ; Tanaka, Leonardo Y. ; Fukai, Tohru ; Laurindo, Francisco R.M. ; Mason, Ronald P. ; Vasquez-Vivar, Jeannette ; Minshall, Richard D. ; Stadler, Krisztian ; Bonini, Marcelo G. . Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway. Free Radical Biology & Medicine , v. 52, p. 427-435, 2012.

  • Sharma, N. K. ; Reyes, A. ; Green, P. ; Caron, M. J. ; BONINI, M. G. ; Gordon, D. M. ; Holt, I. J. ; Santos, J. H. . Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Research , v. 40, p. 712-725, 2012.

  • Chen, Z. ; Bakhshi, F. R. ; Shajahan, A. N. ; Sharma, T. ; Mao, M. ; Trane, A. ; Bernatchez, P. ; van Nieuw Amerongen, G. P. ; BONINI, M. G. ; Skidgel, R. A. ; Malik, A. B. ; Minshall, R. D. . Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition. Molecular Biology of the Cell (Cessou em 2007. Cont. ISSN 1939-4586 Molecular Biology of the Cell (Online)) , v. 23, p. 1388-1398, 2012.

  • Davis, Michael F. ; Zhou, Li ; Ehrenshaft, Marilyn ; Ranguelova, Kalina ; Gunawardena, Harsha P. ; Chen, Xian ; Bonini, Marcelo G. ; Mason, Ronald P. ; Campbell, Sharon L. . Detection of Ras GTPase protein radicals through immuno-spin trapping. Free Radical Biology & Medicine , v. 53, p. 1339-1345, 2012.

  • Towner, R. A. ; Smith, N. ; Saunders, D. ; Henderson, M. ; Downum, K. ; Lupu, F. ; Silasi-Mansat, R. ; Ramirez, D. C. ; Gomez-Mejiba, S. E. ; BONINI, M. G. ; EHRENSHAFT, M. ; MASON, R. P. . In Vivo Imaging of Immuno-Spin Trapped Radicals With Molecular Magnetic Resonance Imaging in a Diabetic Mouse Model. Diabetes (New York, N.Y.) , v. 61, p. 2405-2413, 2012.

  • Mason, Ronald P. ; GANINI, DOUGLAS ; Bonini, Marcelo G. ; Ranguelova, Kalina . Two hypotheses for the oxidation of SOD1-Cu(I). Free Radical Biology & Medicine , v. 53, p. 1991-1992, 2012.

  • Toya, Sophie P. ; Li, Fei ; Bonini, Marcelo G. ; Gomez, Ignatius ; Mao, Mao ; Bachmaier, Kurt W. ; Malik, Asrar B. . Interaction of a Specific Population of Human Embryonic Stem Cell Derived Progenitor Cells with CD11b+ Cells Ameliorates Sepsis-Induced Lung Inflammatory Injury. The American Journal of Pathology (Print) , v. 178, p. 313-324, 2011.

  • Sovari, Ali A ; Bonini, Marcelo G ; Dudley, Samuel C . Effective antioxidant therapy for the management of arrhythmia. Expert Review of Cardiovascular Therapy , v. 9, p. 797-800, 2011.

  • Duma, Danielle ; Fernandes, Daniel ; Bonini, Marcelo G. ; Stadler, Krisztian ; Mason, Ronald P. ; Assreuy, Jamil . NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses. European Journal of Pharmacology , v. 668, p. 285-292, 2011.

  • Siddiqui, M. R. ; Komarova, Y. A. ; Vogel, S. M. ; Gao, X. ; BONINI, M. G. ; Rajasingh, J. ; Zhao, Y.-Y. ; Brovkovych, V. ; Malik, A. B. . Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. The Journal of Cell Biology , v. 193, p. 841-850, 2011.

  • Chatterjee, Saurabh ; Lardinois, Olivier ; Bhattacharjee, Suchandra ; Tucker, Jeff ; Corbett, Jean ; Deterding, Leesa ; Ehrenshaft, Marilyn ; G. Bonini, Marcelo ; Mason, Ronald P. . Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. Free Radical Biology & Medicine , v. 50, p. 988-999, 2011.

  • Sovari, Ali A. ; Iravanian, Shahriar ; Dolmatova, Elena ; Jiao, Zhe ; Liu, Hong ; Zandieh, Shadi ; Kumar, Vibhash ; Wang, Kun ; Bernstein, Kenneth E. ; Bonini, Marcelo G. ; Duffy, Heather S. ; Dudley, Samuel C. . Inhibition of c-Src Tyrosine Kinase Prevents Angiotensin II Mediated Connexin-43 Remodeling and Sudden Cardiac Death. Journal of the American College of Cardiology (Print) , v. 58, p. 2332-2339, 2011.

  • Hickok, J. R. ; Sahni, S. ; Mikhed, Y. ; BONINI, M. G. ; Thomas, D. D. . Nitric Oxide Suppresses Tumor Cell Migration through N-Myc Downstream-regulated Gene-1 (NDRG1) Expression: ROLE OF CHELATABLE IRON. The Journal of Biological Chemistry (Print) , v. 286, p. 41413-41424, 2011.

  • Kovalenko, Olga A. ; Caron, Matthieu J. ; Ulema, Perihan ; Medrano, Carolina ; Thomas, Andrew P. ; Kimura, Masayuki ; Bonini, Marcelo G. ; Herbig, Utz ; Santos, Janine H. . A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell , v. 9, p. 203-219, 2010.

  • Ranguelova, Kalina ; Bonini, Marcelo G. ; Mason, Ronald P. . (Bi)sulfite Oxidation by Cu,Zn-Superoxide Dismutase: Sulfite-Derived, Radical-Initiated Protein Radical Formation. Environmental Health Perspectives , p. na, 2010.

  • Ehrenshaft, Marilyn ; Bonini, Marcelo G. ; Feng, Li ; Chignell, Colin F. ; Mason, Ronald P. . Partial Colocalization of Oxidized, -formylkynurenine-containing Proteins in Mitochondria and Golgi of Keratinocytes. Photochemistry and Photobiology , p. XX-XXX, 2010.

  • BONINI, M. G. ; Gabel, S. A. ; Ranguelova, K. ; STADLER, K. ; DeRose, E. F. ; London, R. E. ; MASON, R. P. . Direct Magnetic Resonance Evidence for Peroxymonocarbonate Involvement in the Cu,Zn-Superoxide Dismutase Peroxidase Catalytic Cycle. The Journal of Biological Chemistry (Print) , v. 284, p. 14618-14627, 2009.

  • Chatterjee, S. ; Lardinois, O. ; BONINI, M. G. ; Bhattacharjee, S. ; STADLER, K. ; Corbett, J. ; Deterding, L. J. ; Tomer, K. B. ; Kadiiska, M. ; MASON, R. P. . Site-Specific Carboxypeptidase B1 Tyrosine Nitration and Pathophysiological Implications following Its Physical Association with Nitric Oxide Synthase-3 in Experimental Sepsis. The Journal of Immunology (1950) , v. 183, p. 4055-4066, 2009.

  • HE, Y. Y. ; Council, S.E. ; Feng, L. ; BONINI, M. G. ; Chignell, C.F. . Spatial distribution of protein damage by singlet oxygen in keratinocytes.. Photochemistry and Photobiology , v. 84, p. 69-74, 2008.

  • Siraki, Arno G. ; Deterding, Leesa J. ; Bonini, Marcelo G. ; Jiang, JinJie ; Ehrenshaft, Marilyn ; Tomer, Kenneth B. ; Mason, Ronald P. . Procainamide, but not N-Acetylprocainamide, Induces Protein Free Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis. Chemical Research in Toxicology , v. 21, p. 1143-1153, 2008.

  • Bonini, M. G. ; STADLER, K. ; Silva, S. d. O. ; Corbett, J. ; Dore, M. ; Petranka, J. ; Fernandes, D. C. ; Tanaka, L. Y. ; Duma, D. ; Laurindo, F. R. M. ; MASON, R. P. . Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation. PNAS. Proceedings of the National Academy of Sciences of the United States of America , v. 105, p. 8569-8574, 2008.

  • STADLER, K ; BONINI, M. G. ; DALLAS, S ; JIANG, J ; RADI, R ; MASON, R ; KADIISKA, M . Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radical Biology & Medicine , p. 866, 2008.

  • STADLER, K. ; BONINI, M. G. ; Dallas, S. ; Duma, D. ; MASON, R. P. ; Kadiiska, M. B. . Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. American Journal of Physiology. Endocrinology and Metabolism , v. 295, p. E456-E462, 2008.

  • BONINI, M. G. ; SIRAKI, A. G. ; ATANASSOV, B. S. ; MASON, R. P. . Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radical Biology & Medicine , v. 42, p. 530-540, 2007.

  • BONINI, M. G. ; SIRAKI, A. G. ; Bhattacharjee, S ; MASON, R. P. . Glutathione-induced radical formation on lactoperoxidase does not correlate with the enzyme's peroxidase activity. Free Radical Biology & Medicine , v. 42, p. 985-992, 2007.

  • RAINES, K. W. ; BONINI, M. G. ; CAMPBELL, S. L. . Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases. Cardiovascular Research , v. 75, p. 229-239, 2007.

  • Bhattacharjee, S ; Deterding LJ ; Jiang, J. ; BONINI, M. G. ; Tomer, K. B. ; Ramirez D.C. ; MASON, R. P. . Electron Transfer between a Tyrosyl Radical and a Cysteine Residue in Hemoproteins: Spin Trapping Analysis.. Journal of the American Chemical Society , v. 129, p. 13493-13501, 2007.

  • SIRAKI, A. G. ; BONINI, M. G. ; Jiang, J. ; EHRENSHAFT, M. ; MASON, R. P. . Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chemical Research in Toxicology , v. 20, p. 1038-1045, 2007.

  • BONINI, M. G. ; ROTA, C. ; TOMASI, A. ; MASON, R. P. . The oxidation of 2',7'-dichlorofluorescin to reactive oxygen species: A self-fulfilling prophesy?. Free Radical Biology and Medicine, Estados Unidos, v. 40, n.6, p. 968, 2006.

  • LIMA, E. S. ; BONINI, M. G. ; Barbeito, HV ; Souza HP ; AUGUSTO, O. ; ABDALLA, D. S. . Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation.. Free Radicals in Biology and Medicine, v. 39, p. 532-539, 2005.

  • BONINI, M. G. ; Fernandes D. C. ; AUGUSTO, O. . Albumin oxidation to diverse eadicals by the peroxidase activity of Cu, Zn-Superoxide dismutase in the presence of bicarbonate or nitrite: Diffusible radicals produce cysteinyl and Solvent-exposed and -unexposed tyrosyl radicals. Biochemistry, v. 43, n.2, p. 344-351, 2004.

  • AUGUSTO, O. ; BONINI, M. G. ; TRINDADE, D. F. . Spin Trapping of glutathyil and protein radicals produced from nitric oxide derived oxidants. Free Radicals in Biology and Medicine, Estados Unidos, v. 36, n.10, p. 1224-1232, 2004.

  • BONINI, M. G. ; MYIAMOTO, S. ; MASCIO, P. ; AUGUSTO, O. . Production of the Carbonate Radical Anion during Xanthine Oxidase Turnover in the Presence of Bicarbonate.. Journal of Biological Chemistry, v. 279, p. 51836-51843, 2004.

  • BONINI, M. G. ; MASON, R. P. ; AUGUSTO, O. . The Mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) Diverts Peroxynitrite Decomposition fromNitrating to Nitrosating Species. Chemical Research in Toxicology, v. 15, p. 506-511, 2002.

  • BONINI, M. G. ; SANTOS, C. X. C. ; AUGUSTO, O. ; AMANSO, A. M. ; de Menezes SL ; LINARES, E. . Nitrogen dioxide and carbonate radical anion : two emerging radicals in biology. Free Radicals in Biology and Medicine, EUA, v. 32, n.9, p. 841-859, 2002.

  • BONINI, M. G. ; AUGUSTO, O. . Carbon Dioxide Stimulates the Production of Thyil, Sulfinyl and Disulfide Radical Anion from Thiol Oxidation by Peroxynitrite. Journal of Biological chemistry, v. 276, n.13, p. 9749-9754, 2001.

  • SANTOS, C. X. C. ; BONINI, M. G. ; AUGUSTO, O. . Role of the Carbonate Radical Anion in Tyrosine Nitration and Hydroxylation by Peroxynitrite. Archives of Biochemistry and Biophysics, v. 377, n.1, p. 146-152, 2000.

  • BONINI, M. G. ; MARTINEZ, G. R. ; SIES, H. ; BRIVIBA, K. ; AUGUSTO, O. ; MASCIO, P. ; MAURER, P. ; HEROLD, S. ; ROTHLISBERGER, U. ; KOPPENOL, W. H. . Peroxynitrite does not decompose to Singlet Oxygen and Nitroxyl. Proceedings of the National Academy of Sciences USA, v. 97, n.19, p. 10307-10312, 2000.

  • BONINI, M. G. ; RADI, R. ; FERRER-SUETA, G. ; Da C. Ferreira, AM ; AUGUSTO, O. . Direct EPR Detection of the Carbonate Radical Anion Produced from Peroxynitrite and Carbon dioxide. Journal of Biological Chemistry, v. 274, n.16, p. 10802-10806, 1999.

  • SAMOVARI, A. A. ; SMALL, O. ; BONINI, M. G. ; KOCHERIL, A. G. ; DUDLEY, S. C. . Role of oxidative stress in ventricular Arrhythmias in Ventricular Arrhythmias, from principles to patients.. In: Dudley, SC; Kocheril AG; Sovari, A.. (Org.). Ventricular Arrhythmia. 1ed.New York: Nova Science, 2013, v. 1, p. 1-.

  • BONINI, M. G. ; DULL, R. O. ; Minshall, R. D. . Caveolin-1 Regulation of eNOS function and oxidative stress in the endothelium. In: I Laher. (Org.). SYSTEMS BIOLOGY OF FREE RADICALS AND ANTIOXIDANTS. 1ed.: Spring-Verlay, 2013, v. 1, p. 1-1.

  • BONINI, M. G. ; STADLER, K. ; Corbett J ; Dore M ; Duma D ; Petranka J ; Fernandes D. C. ; Tanaka L.Y. ; Laurindo, F.R.M. ; Silva SO ; MASON, R. P. . Constitutve nitric oxide synthase activation mediates nitroglycerin-induced vasodilation. In: Gordon Research Conference - Oxygen Radicals, 2008, Ventura Beach, CA. Anais do Congresso, 2008.

  • STADLER, K. ; BONINI, M. G. ; Dallas, S. ; MASON, R. P. ; Kadiiska MB . Key role of inducible nitric oxide synthase in free radical production and protein oxidation induced by ketosis. In: Gordon Research Conference - Oxygen Radicals, 2008, Ventura Beach, CA. Anais do Congresso, 2008.

  • SIRAKI, A. G. ; Deterding LJ ; BONINI, M. G. ; EHRENSHAFT, M. ; Tomer, K. B. ; Jiang, J. ; MASON, R. P. . Procainamide, But Not N-Acetylprocainamide, Induces Protein Free Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis.. In: Gordon Research Conference, 2008, Ventura Beach, CA. Anas do Congresso, 2008.

  • STADLER, K. ; BONINI, M. G. ; Dallas, S. ; Jiang, J. ; MASON, R. P. ; Kadiiska MB . Unraveling a free radical mechanism in vivo and the causative role of iNOS. In: Gordon Research Conference - Oxidative Stress, 2007, Ventura - CA. Anais do Congresso, 2007.

  • BONINI, M. G. ; MASON, R. P. . Immunospin-trapping based free radical immaging in cells. In: 10th conference of the international union of biochemistry and molecular biology (IUBMB), 2007, Salvador - BA. anais do congresso, 2007.

  • BONINI, M. G. ; STADLER, K. ; Silva SO ; Corbett J ; Dore M ; Petranka J ; Duma D ; Fernandes D. C. ; Tanaka L.Y. ; Laurindo, F.R.M. ; MASON, R. P. . Constitutive nitric oxide synthase activation is a significant route mediating nitroglycerin-induced vasodilation. In: 14th Annual Society for Free Radical Biology and Medicine, 2007, Washington, DC. Free Radical Biology and Medicine, 2007.

  • BONINI, M. G. ; RAINES, K. W. ; MASON, R. P. ; CAMPBELL, S. L. . P21Ras cysteine 118 thiyl radical formation as an obligatory intermediate in nitric oxide mediated guanine nucleotide exchange.. In: 14th Annual Meeting of the Society for Free Radical Biology and Medicine, 2007, Washington, DC. Free Radical Biology and Medicine, 2007.

  • BONINI, M. G. ; MASON, R. P. . Guanosine monophosphate, but not guanosine and its higher phosphate congeners, mediates heme-periphery electron transfers in lactoperoxidase. In: 14 th Annual Meeting of the Society for Free Radical Biology and Medicine, 2007, Washington, DC. Free Radical Biology and Medicine, 2007.

  • STADLER, K. ; BONINI, M. G. ; MASON, R. P. ; Kadiiska MB . Key role of inducible nitric oxide synthase in free radical production and protein oxidation induced by ketosis. In: 14 th Annual Meeting of the Society for Free Radical Biology and Medicine, 2007, Washington, DC. Free Radical Biology and Medicine, 2007.

  • STADLER, K. ; BONINI, M. G. ; MASON, R. P. ; Kadiiska MB . Inducible nitric oxide synthase overexpression in diabetic target organs triggers increased lipid peroxidation and tissue damage. In: 14 th Annual Meeting of the Society for Free Radical Biology and Medicine, 2007, Washington, DC. Free Radical Biology and Medicine, 2007.

  • Bhattacharjee, S ; Deterding LJ ; Jiang, J. ; BONINI, M. G. ; Tomer, K. B. ; Ramirez D.C. ; MASON, R. P. . Electron Transfer Between a Tyrosyl Radical and a Cysteine Residue in Hemoproteins: Spin Trapping Analysis. In: 14th Annual Meeting of the Society for Free Radical Biology and Medicine, 2007, Washington, DC. SFRBM journal supplement 1 -2007. SFRBM-Indianapolis, 2007.

  • Duma D ; Fernandes D. ; BONINI, M. G. ; STADLER, K. ; MASON, R. P. ; Assreuy J. . NOS1-Derived Nitric Oxide as a Signaling Effector for the Initiation of Systemic Inflammatory Reaction in Sepsis Models. In: 14th Annual Meeting of the SOciety for Free Radical Biology and Medicine, 2007, Washington, DC. SFRBM Journal - supplement 1 2007. SFRBM-Indianapolis, 2007.

  • SIRAKI, A. G. ; BONINI, M. G. ; EHRENSHAFT, M. ; Jiang, J. ; MASON, R. P. . Procainamide, But Not N-Acetylprocainamide, Induces Protein Free Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis.. In: 14th Annual Meeting of the Society for Free Radical Biology and Medicine, 2007, Washington, DC. SFRBM Journal - Spullement 1 -2007. SFRBM-Indianapolis, 2007.

  • Towner, R. ; Smith, N. ; Saunders, D. ; Henderson, M. ; Hensley K. ; West, M. ; BONINI, M. G. ; MASON, R. P. . In Vivo Detection of DMPO-Adducts Using Molecular Targeted MRI. In: 14th Annual Meeting of Society for Free Radical Biology and Medicine, 2007, Washington, DC. SFRBM Journal supplement 1 2007. SFRBM - Indianapolis, 2007.

  • Brar, S. ; Meyer, J. N. ; BONINI, M. G. ; van Houten, B. ; Martin, W.J, II . Bleomycin down regulates PKD expression in A549 cells and induces mitochondrial and nuclear DNA damage. In: 3rd International NIH mitochondria minisymposium, 2007, Bethesda, MD. Anais do encontro. Washington, 2008.

  • STADLER, K. ; BONINI, M. G. ; Dallas, S. ; Jiang, J. ; MASON, R. P. ; Kadiiska MB . The "radical" side of diabetes - unraveling a free radical mechanism in vivo and the causative role of iNOS. In: 13 th Annual Meeting of the Society for Free Radical Biology and Medicine, 2006, Denver. CO. Supplement to FRBM, 2006.

  • BONINI, M. G. ; MASON, R. P. . Immunospin-trapping based protein free radical imaging in sub-cellular structures. In: 13th Annual Meeting of the SOciety for Free Radical Biology and Medicine, 2006, Denver, CO. Supplement to FRBM, 2006.

  • BONINI, M. G. ; ATANASSOV, B. S. ; SIRAKI, A. G. ; MASON, R. P. . Catalase inactivation by HOCl - Immunospin trapping reveal protein radical formation in test tubes and cell cultures. In: 8 th Spin trapping meeting, 2005, Columbus. Anais do 8th spin trapping meeting, 2005.

  • SIRAKI, A. G. ; BONINI, M. G. ; MASON, R. P. . Biting the hand that feeds: use of a novel DMPO-protein antibody in detection of a drug-induced myeloperoxidase radical adduct upon myeloperoxidase-catalyzed peroxidation of aminoglutethimide.. In: 12th annual meeting of the society for free radical Biology and Medicine, 2005, Austin, TX. Free Radical Biology and Medicine Supplement, 2005.

  • BONINI, M. G. ; SIRAKI, A. G. ; ATANASSOV, B. S. ; MASON, R. P. . Catalase inactivation by hypochlorite correlates with protein radical formation, aggregation and heme modification.. In: 12 th annual meeting of the society for free radical biology and medicine, 2005, Austin TX. Free Radic. Biol. Med. Suppl., 2005.

  • GOMES, C. S. ; MAURICIO, A. Q. ; MATTOS, T. ; BONINI, M. G. ; AUGUSTO, O. ; Hermes-Lima M . Mechanistic studies about PIH action as an antioxidant due to its iron chelating properties. In: XXXIII Reunião anual da Sociedade Brasileira de Bioquímica e Biologia Molecular, 2004, Caxambu. Anais da XXXIII Reunião anual da SBBQ, 2004.

  • CORREA, R. ; COSTA, A. L. L. ; MAURICIO, A. Q. ; BERNARDO-FILHO, M. ; BONINI, M. G. ; AUGUSTO, O. ; Hermes-Lima M . Hydroxyl radical formation from stannous ion-an EPR study. In: XXXIII Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular, 2004, Caxambú. Anais da XXXIII Reunião anual da SBBQ, 2004.

  • BONINI, M. G. ; MIYAMOTO, S. ; MASCIO, P. ; AUGUSTO, O. . Production of the Carbonate Radical Anion during Xanthine Oxidase Turnover in the Presence of Bicarbonate.. In: 11 th Annual Meeting of the Society for Free Radical Biology and Medicine, 2004, Saint Thomas. Free Radical Biology and Medicine (Supplement), 2004.

  • TRINDADE, D. F. ; BONINI, M. G. ; AUGUSTO, O. . Intermediacy of the peroxycarbonate anion in the oxidation of BSA and glutathione by hydrogen peroxide/bicarbonate. In: XII Biennial Meeting of the Society for Free Radical Research, 2004, Buenos Aires. Livro de resumos do XII Biennial Meeting of the Society for Free Radical Research, 2004.

  • BONINI, M. G. ; AUGUSTO, O. ; MASCIO, P. ; MYIAMOTO, S. . Evidences for carbonate radical anion production during xanthine oxidase turnover. In: XXXII Reuniao anual da sociedade brasileira de bioquimica e biologia molecular, 2003, Caxambu - MG. Anais da XXXII reuniao anual da SBBq, 2003.

  • BONINI, M. G. ; Fernandes D. C. ; AUGUSTO, O. . Albumin Oxidation to Diverse Radicals by the Peroxidase Activity of Cu,Zn-Superoxide Dismutase in the Presence of Bicarbonate or Nitrite.. In: 10 th annual meeting of the society for free radical biology and medicine, 2003, Seattle. Anais do 10 th annual meeting of the society for free radical biology and medicine, 2003.

  • BONINI, M. G. ; MYIAMOTO, S. ; MASCIO, P. ; AUGUSTO, O. . Evidences for carbonate radical anion production during xanthine oxidase turnover. In: 10 th annual meeting of the society for free radical biology and medicine, 2003, Seattle. anais do 10 th annual meeting of the society for free radical biology and medicine, 2003.

  • BONINI, M. G. ; MASON, R. P. ; AUGUSTO, O. . The mechanism by which 2,2,6,6 tetramethylpiperidene 1- oxyl tempol diverts peroxynitrite decomposition from nitrating to nitrosating intermediates. In: 7th International symposium on Spin Trapping, 2002, Chapel Hill. Anais do 7th International symposium on spin Trapping, 2002.

  • BONINI, M. G. ; AUGUSTO, O. . Shift of peroxynitrite-mediated nitration to nitrosation pathways by tempol. A potential peroxynitrite marker?. In: 224 th National Meeting of the American Chemical Society, 2002, Boston. ABSTR. PAP. AM. Chem. Soc.. Washington, USA: American Chemical Society, 2002. v. 224.

  • BONINI, M. G. ; AUGUSTO, O. . Production of Albumin-derived radicals by the peroxidase activity of Cu/Zn SOD in the presence of NO2- and HCO3-. In: 8th Annual Meeting of the Oxygen Society, 2001, Research Triangle Park. Free Radical Biology and Medicine 2001, 2001. v. SUPL1.

  • BONINI, M. G. ; MASON, R. P. ; AUGUSTO, O. . The mechanism by which 4-hydroxy-2,2,6,6 tetramethyl piperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species. In: 8th Annual Meeting of the Oxygen Society, 2001, Reseach Triangle Park. Free Radical Biology & Medicine, 2001. v. supl.

  • BONINI, M. G. ; AUGUSTO, O. . Carbon Dioxide stimulates the production of thyil, sulfinyl and disulfide radical anion from thiol oxidation by peroxynitrite. In: 7th Annual Meeting of the Oxygen Society, 2001, San Diego. Free radical Biology & medicine, 2001. v. SUP 1.

  • BONINI, M. G. ; AUGUSTO, O. . Carbon Dioxide Stimulates the Production of Thyil, Sulfinyl and Disulfide Radical Anion from Thiol Oxidation by Peroxynitrite. In: Congresso do Deaprtamento de Bioquímica 30 anos, 2001, São Paulo. Livro de Resumos do Congresso, 2001.

  • BONINI, M. G. ; AUGUSTO, O. ; SANTOS, C. X. C. . Role of Carbonate Radical Anion in Tyrosine Nitration and Hydroxylation by Peroxynitrite. In: XXIX Reunião Anual da Sociedade Brasileira de Bioquímica e Biolgia Molecular, 2000, Caxambu. Anais da XXIX Reunião da Sociedade Brasileira de Bioquímica e Biologia Molecular, 2000.

  • BONINI, M. G. ; AUGUSTO, O. . Carbon Dioxide Stimulates the One electron Oxidation of Thiols by Peroxynitrite. In: XXIX Reunião da Sociedade Brasileira de Bioquímica e Biologia Molecular, 2000, Caxambu. Anais da XXIX Reunião da Sociedade brasileira de Bioquímica e Biologia Molecular, 2000.

  • BONINI, M. G. ; RADI, R. ; FERRER-SUETA, G. ; Da C. Ferreira, AM ; AUGUSTO, O. . Direct EPR Detection of the Carbonate Radical Anion produced from peroxynitrite and Carbon Dioxide. In: First Meeting of the South American Group for free Radical Research, 1999, Florianópolis. Livro de resumos, 1999.

  • Ansenberger-Fricano, Kristine ; HART, P. ; ABREU, A. L. P. ; GANINI, DOUGLAS ; Mao, M. ; BAIG, M. ; Green, P. ; VARGAS, M. ; THIERAULT, K. ; BERA, S. ; DIAMOND, A. ; KAJDACSY-BALLA, C. ; MINSHALL, R. ; Santos, Janine H. ; CONSOLARO, M. ; Bonini, M. G. . SOD2 promotes the metabolic reprogramming and sustains the Warburg effect via AMPK-dependent signaling in cancer. Nature Communications , 2013.

  • BAIG, M. ; BAKHSHI, F. ; Ansenberger-Fricano, Kristine ; Mao, M. ; DENG, J. ; CHATTERJEE, S. ; BLOCK, M. ; GAO, X. ; VOGEL, S. ; Minshall, R. D. ; YE, R. ; CHRISTIMAN, J. ; GANTNER, B. ; Bonini, M. G. . nNOS/NOS1-dependent regulation of the systemic inflammatory response via suppressor of cytokine signaling (SOCS-1) inhibition in response to lypopolyssacharide in macrophages. Nature Immunology , 2013.

  • BONINI, M. G. ; GANTNER, BENJAMIN N. . The multiple roles of AMPK in cancer why the one size fits all hypothesis does not fit at all?. IUBMB Life (London. Print) , 2013.

  • Bonini, M. G. . Mechanisms of mitochondria-driven cancer cell reprogramming.. 2013. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Mechanisms of mitochondria-driven cancer cell reprogramming.. 2013. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Mechanisms of oxidative stress-induced endothelial cell reprogramming in pulmonary arterial hypertension. 2013. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Ablation of nNOS/NOS1 Leads to the Suppression of the Systemic Inflammatory Response Via Suppressor of Cytokine Signaling (SOCS-1) Upregulation. 2012. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . From peroxynitrite to MnSOD: a radical journey. 2012. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Mitochondrial mechanisms of tumor cell metabolic regulation.. 2012. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Mitochondrial mechanisms of AMPK activation.. 2012. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Mitochondrial mechanisms of AMP-activated kinase (AMPK) activation in cancer.. 2012. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Enzymatic functions defined by tracking redox reactions: the example of MnSOD.. 2012. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Nitroglycerin-induced loss of caveolin-1 results in endothelial nitric oxide dysfunction and vascular irresponsiveness to vasodilators.. 2011. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Manganese superoxide dismutase peroxidase activity sustains tumor resistance against apoptosis.. 2011. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Endothelial nitric oxide (dys)function at the crossroads of nitroglycerin biologic activities,. 2011. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Laboratory of Toxicology and Pharmacology Retreat,. 2011. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . MnSOD peroxidase activity as a novel mitochondrial redox regulator. 2010. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Nitroglycerin-dependent vasodilation is mediated through signal transduction pathways.. 2009. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Linking oxidative chemistry to pathophysiology through the identification cellular redox switches ?. 2008. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Constitutive nitric oxide synthase activation as an important route for nitroglycerin-induced vasorelaxation. 2008. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Constitutive nitric oxide synthase activation as an important route for nitroglycerin-induced vasorelaxation. 2008. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Host : Dr. Samuel C. Dudley. 2008. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . The radical nature of detecting free radicals and biological oxidants. 2008. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Nitric oxide synthase activation as new pathway for nitroglycerin-induced vasorelaxation 2. 2007. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Protein-bound free radical imaging in sub-cellular structures. 2007. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Seeing is believing: Immunospin-trapping based imaging of protein free radical production in sub-cellular structures.. 2006. (Apresentação de Trabalho/Conferência ou palestra).

  • Bonini, M. G. . Catalase inactivation by HOCl - immunospin trapping reveals protein radical formation in test tubes and cells.. 2005. (Apresentação de Trabalho/Conferência ou palestra).

  • BONINI, M . Constitutive Nitric Oxide Synthase Activation is a significant route mediating nitroglycerine induced vasodilation. 2008 (Invited Speaker) .

  • BONINI, M . Constitutive Nitric Oxide Synthase Activation is a significant route mediating nitroglycerine induced vasodilation. 2008 (Invited Speaker) .

  • BONINI, M . Reactive oxygen and nitrogen species formation and detection in biological systems. 2008 (Invited Speaker) .

  • BONINI, M. G. . Immunolocalization of protein bound free radical formation in sub-cellular structures (Palestra proferida a convite). 2007.

  • BONINI, M . Constitutive Nitric Oxide Synthase Activation is a significant route mediating nitroglycerine induced vasodilation. 2007 (Invited Speaker) .

  • BONINI, M. G. . Seeing is believing: Localization of protein radical formation in sub-cellular structures (Palestra proferida a convite). 2006 (Invited Speaker) .

  • BONINI, M. G. . Catalase Inactivation by Hypochloryte correlates with protein aggregation, protein radical formation and heme modification (palestra proferida a convite). 2005 (Invited Speaker) .

  • BONINI, M. G. . Catalase inactivation through free radical mechanisms induced by hypochlorous acid (Palestra proferida a convite). 2004 (Invited Speaker) .

  • BONINI, M. G. ; SANTOS, C. X. C. ; LINARES, E. ; AUGUSTO, O. ; Fernandes D. C. . Peroxynitrite, Carbon Dioxide and Free Radical Production. 2002 (Curso Virtual Vinculado à Oxygen Society) .

Seção coletada automaticamente pelo Escavador

Projetos de pesquisa

  • 2013 - Atual

    Mechanisms of nitroglycerin-induced eNOS dysfunction and vascular toxicity., Descrição: This grant will investigate nitroglycerin-induced caveolin-1 depletion and PTEN inhibition as potential mechanisms underpinning nitrate tolerance.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, M. G. - Coordenador., Financiador(es): American Heart Association - Auxílio financeiro., Número de produções C, T & A: 1

  • 2013 - Atual

    Projeto de professor visitante do Ciências se Fronteiras: Translational approaches to selectively target HPV-transformed cells via manipulating mitochondrial redox signaling, Descrição: Projeto de professor visitante do Ciências se Fronteiras para o Programa de Pós-Graduação em Biociências Aplicadas à Farmácia/Universidade Estadual de Maringá/PR -BR An intriguing question is whether the appearance of stem-like cells in cancer involves the induction of OSK expression in somatic cells propitiated by changes in intracellular signaling events. In fact, our group identified dysregulations in the mitochondrial metabolism of reactive oxygen species (ROS) as a driving force behind OSK expression in somatic epithelial cells that led to the appearance of cells with cancer stem cell characteristics. Specifically, we found that the overexpression of MnSOD and the consequential outflow of ROS from mitochondria upregulated the expression of numerous genes involved in reprogramming. From these observations, we hypothesized that viral infections (e.g. HPV), which knowingly affect mitochondrial function and ROS production, induce malignant transformation via MnSOD upregulation and the mitochondrial-ROS elicited OSK expression. We also conceptualized and synthesized a new mitochondrial-targeted antioxidant compound that we anticipate will be effective in selectively killing HPV-induced cancerous stem-like cells by selectively impeding the transformation of infected cells.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (2) Doutorado: (3) . , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, M. G. - Integrante / Marcia Edilaine Lopes Consolaro - Coordenador / Sueli de Oliveira Silva Lautschenlagen - Integrante / Bianca Altrão Ratti - Integrante / André Luesldorf Pimenta de Abreu - Integrante / Fabrícia Gimenes - Integrante / SOUZA, R. P. - Integrante / Andréia Buffon - Integrante., Financiador(es): Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Bolsa.Número de orientações: 1

  • 2012 - Atual

    Role of Manganese Superoxide Dismutase (MnSOD) Peroxidase Activity in Cellular Resistance Against Apoptosis, Descrição: United States Department of Defense Grant 61758LS -Army Research Office (ARO) 2012 -2015 The ultimate goal of this proposal will be to elucidate the molecular pathways that promote Listeria monocytogenes survival within host cells and the transformation of a soil dweller into a cell invader.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (0) / Especialização: (0) / Mestrado acadêmico: (0) / Mestrado profissional: (0) / Doutorado: (1) . , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, Marcelo G. - Coordenador., Financiador(es): United States Department of Defense - Auxílio financeiro.

  • 2012 - Atual

    Impact of MnSOD overexpression on Glut4 membrane accumulation in cancer cells, Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, M. G. - Coordenador / Marcia Edilaine Lopes Consolaro - Integrante / André Luesldorf Pimenta de Abreu - Integrante., Número de orientações: 1

  • 2011 - Atual

    Electron Paramagnetic Resonance Spectrometer, Descrição: NCRR Shared Instrumentation Grant for an EPR Spectrometer to detect and measure reactive free radicals and other paramagnetic species primarily in biological biologic samples.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, M. G. - Coordenador., Financiador(es): National Institute of Health - Auxílio financeiro.

  • 2011 - Atual

    DEFINING MECHANISMS UNDERLYING LISTERIA MONOCYTOGENES CARDIAC INFECTIONS, Descrição: Co-Investigator Grant 1R21AI099339-01 PI: Freitag, N.E. Agency: National Institute of Allergy and Infectious Diseases/NIH. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, Marcelo G. - Integrante / Nancy Elizabeth Freitag - Coordenador., Financiador(es): National Institute of Health - Auxílio financeiro.

  • 2011 - Atual

    Role of nitric oxide synthases in nitroglycerin-induced vasodilation and tolerance., Descrição: In this project we will define what is the relative contribution of each isoform of nitric oxide synthase (neuronal and endothelial) for nitroglycerin-induced vasodilation and investigate the role of PTEN constitutive inhibition in tolerance.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, M. G. - Coordenador., Financiador(es): American Heart Association - Auxílio financeiro.

  • 2011 - Atual

    LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLS, Descrição: Co-Investigator Grant 2R56AI041816-18A1 PI: Freitag, Nancy E. Agency: National Institute of Allergy and Infectious Diseases/NIH. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, Marcelo G. - Integrante / Nancy Elizabeth Freitag - Coordenador.

  • 2010 - Atual

    Signal transduction via the PI3k/Akt/PTEN pathways underlies the development of nitroglycerin tolerance., Descrição: The overall objective of this grant is to demonstrate that signal transduction through the PI3k/Akt pathway underlie nitroglycerin pharmacologic and toxic effects in the endothelium.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, M. G. - Coordenador., Financiador(es): American Heart Association - Auxílio financeiro.

  • 2010 - Atual

    Training Grant in mechanisms of cardiovascular diseases, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, M. G. - Coordenador / Ansenberger-Fricano, Kristine - Integrante., Financiador(es): National Institute of Health - Auxílio financeiro.

  • 2009 - Atual

    PI3K/Akt involvement in nitroglycerin-induced vasodilation, Descrição: Projeto financiado pela American Heart Association 2009-2013. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marcelo Gialluisi Bonini - Coordenador., Financiador(es): American Heart Association - Auxílio financeiro.

  • 2000 - Atual

    Signaling of Endothelial Permeability and Lung Vascular Injury, Descrição: The overall objective of the Program Project is to define the critical signaling mechanisms mediating the loss of pulmonary vascular barrier function that in turn induces pulmonary edema. The Program will focus on both the paracellular and transcellular mechanisms leading to increased lung microvessel permeability.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marcelo Gialluisi Bonini - Integrante / Bonini, M. G. - Coordenador., Financiador(es): National Institute of Health - Auxílio financeiro.

Seção coletada automaticamente pelo Escavador

Prêmios

2012

Young Investigator Award - Travel Award to Kristine Ansenberger Fricano, Society for Free radical biology and medicine.

2012

Constance Campbell Award to Kristine Ansenberger Fricano, Illinois Symposium on Reproductive Biology.

2009

Intramural paper of the month (Bonini, et al., J. Biol. Chem., 2009), NIEHS.

2009

2008 NIEHS Paper of the year (Bonini, et al., Proc. Natl. Acad. Sci., USA), NIEHS.

2008

Intramural Paper Of the Month (Stadler, Bonini, et al., Am. J. Physiol., 2008, NIEHS.

2008

Intramural paper of the Month (Bonini, et al.) Proc. Natl Acad. Sci, 2008, NIEHS.

2007

IUBMB-Young Scientist Forum Award, International Union of Biochemistry and Molecular Biology.

2007

Fellowship Award for Research Excelence (FARE), National Institutes of Health - USA.

2007

Young Investigator Award, Society for Free Radical Biology and Medicine.

2005

Young Investigator Award, Society for free radical Biology and Medicine.

2003

Premio Jovem Cientista, Instituto de Quimica da Universidade de Sao Paulo.

2003

Premio Jovem Talento em Ciencias da Vida (Finalista), Amersham Pharmacia.

2003

Young Investigator Award, Society for Free Radical Biology and Medicine.

2002

Young Investigator Award, Organizing commitee of the 7th international symposium on spin trapping.

2001

Young Investigator Award - Travel Award, Society for free radical biology and medicine.

Histórico profissional

Seção coletada automaticamente pelo Escavador

Endereço profissional

  • University of Illinois at Chicago, College of Medicine. , 909 S. wolcott Ave, COMRB 1131, COMRB 1131, 60612 - Chicago, - Estados Unidos

Seção coletada automaticamente pelo Escavador

Experiência profissional

  • 2012 - Atual

    Universidade Estadual de Maringá

    Vínculo: Professor Visitante, Enquadramento Funcional: Professor visitante e orientador de doutorado

    Outras informações:
    Programa de Pós-Graduação em Biociências Aplicadas à Farmácia (Cursos de Mestrado e Doutorado)/Universidade Estadual de Maringá/PR/Brasil Área de Farmácia-CAPES; nota 4,0

  • 2015 - Atual

    University of Illinois at Chicago

    Vínculo: Servidor Público, Enquadramento Funcional: Professor Associado, Carga horária: 40

  • 2015 - Atual

    University of Illinois at Chicago

    Vínculo: Servidor Público, Enquadramento Funcional: Associate Vice Head For Research, Carga horária: 40

  • 2009 - Atual

    University of Illinois at Chicago

    Vínculo: Director, Enquadramento Funcional: Director of the Oxidative Stress Core, Carga horária: 40

  • 2009 - 2015

    University of Illinois at Chicago

    Vínculo: , Enquadramento Funcional: Assistant Professor, Carga horária: 40

  • 2008 - 2009

    National Institute Of Environmental Health Sciences

    Vínculo: Research Scientist, Enquadramento Funcional: Research Scientist, Carga horária: 40, Regime: Dedicação exclusiva.

    Outras informações:
    Área de pesquisa: Bioquímica'; Análises toxicológicas; Farmacologia

  • 2004 - 2007

    National Institute Of Environmental Health Sciences

    Vínculo: Bolsista recém-doutor, Enquadramento Funcional: Postdoctoral Fellow, Carga horária: 40, Regime: Dedicação exclusiva.

    Atividades

    • 05/2004 - 09/2009

      Treinamentos ministrados , Laboratory of Pharmacology and Chemistry, .,Treinamentos ministrados, (TREINAMENTO RECEBIDO ) Pos doutorado (NIEHS/NIH)

  • 1999 - 2004

    Universidade de São Paulo

    Vínculo: aluno de pós graduação, Enquadramento Funcional: aluno de doutorado, Carga horária: 40, Regime: Dedicação exclusiva.

    Atividades

    • 08/2002 - 12/2002

      Ensino, Monitoria - QBQ 215 - Bioquímica, Nível: Aperfeiçoamento,Disciplinas ministradas, Monitoria em Bioquímica -Bioquímica para Farmácia - Enzimologia e Metabolismo

    • 01/2000 - 01/2000

      Ensino, QBQ-2000, Nível: Graduação,Disciplinas ministradas, Métodos Experimentais em Bioquímica

    • 08/1999 - 11/1999

      Ensino, Monitoria - QBQ 215 - Bioquímica, Nível: Aperfeiçoamento,Disciplinas ministradas, Monitoria em Bioquímica : Estrutura de Biomoléculas e Metabolismo QBQ 215N

    • 05/1996 - 08/1997

      Estágios , Instituto de Química, .,Estágio realizado, Iniciação científica - Estudo de compostos organolantanídeos contendo o ânion isopropenil-ciclopentadieneto.