Lorenzo Cianni

Idiomas

Áreas de atuação

Produções bibliográficas

• MICHELI, EMANUELA ; ALTIERI, ALESSANDRO ; CIANNI, LORENZO ; CINGOLANI, CHIARA ; IACHETTINI, SARA ; BIANCO, ARMANDODORIANO ; LEONETTI, CARLO ; CACCHIONE, STEFANO ; BIROCCIO, ANNAMARIA ; FRANCESCHIN, MARCO ; RIZZO, ANGELA . Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells. Biochimie (Paris. Print) , v. 125, p. 223-231, 2016.

• Micheli E. ; CIANNI, L. ; ALESSANDRO, A. ; IACCHETTI, S. ; Biroccio A. ; M. Franceschin ; A. Bianco . ?Interaction of G4-ligands with different G-quadruplex forming sequences of oncogene promoters?. 2013. (Apresentação de Trabalho/Congresso).

Projetos de pesquisa

• 2013 - 2014

  The natural alkaloid compounds as DNA G-quadruplex ligands: evaluation and discovery of the anti-cancer drugs, Descrição: Chinese traditional medicine is rich of bioactive natural compounds, which must be fully explored and characterized. The first aim of the present project is the isolation of new aromatic natural compounds from Chinese traditional medicine preparations and their evaluation as G-quadruplex ligands and telomerase inhibitors. In fact, a great number of previous studies have shown that the features shared by many of G-quadruplex ligands include a large flat aromatic surface, presence of cationic charges, and ability to adopt a terminal stacking mode. Compounds with these features will be searched in the extracts of Chinese herbs and plants. Another very important aspect for the biological and pharmaceutical application of these compounds is their solubility in water; this aspect will be also explored. Berberine and its derivatives show optimal characteristics, since they present an aromatic system of several fused rings and a permanent positive charge, due to the quaternary nitrogen atom inserted in this system. Synthetic modifications of the isolated natural occurring compounds can be designed to improve their ability to induce and stabilize G-quadruplex structures and to inhibit human telomerase, as in the case of berberine derivatives . These modifications can be efficiently improved by molecular modelling simulations. In particular, it seems particularly interesting to add flexible side chains to the aromatic moiety of these alkaloids or to dimerize the structures, since each system overlap with only half of the G-tetrad. The study of the interactions between the isolated and synthesized compounds and duplex and quadruplex DNA will be carried out by ESI mass spectrometry, NMR and spectroscopic techniques. The study of the biological activity of the most interesting compounds, as telomerase inhibitors and thus potential anticancer agents, will be evaluated.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (3) Doutorado: (4) . , Integrantes: Lorenzo Cianni - Coordenador / Armadodoriano Bianco - Integrante / Marco Franceschin - Integrante / Alessandro Altieri - Integrante / Lian-Quan Gu - Integrante.

Prêmios