David Ian Watkins

Idiomas

Áreas de atuação

Produções bibliográficas

• MARTINS, M. A. ; WILSON, N. A. ; PIASKOWSKI, S. M. ; WEISGRAU, K. L. ; FURLOTT, J. R. ; BONALDO, M. C. ; VELOSO DE SANTANA, M. G. ; RUDERSDORF, R. A. ; RAKASZ, E. G. ; KEATING, K. D. ; CHIUCHIOLO, M. J. ; PIATAK, M. ; ALLISON, D. B. ; PARKS, C. L. ; GALLER, R. ; LIFSON, J. D. ; WATKINS, D. I. . Vaccination with gag, vif, and nef Gene Fragments Affords Partial Control of Viral Replication after Mucosal Challenge with SIVmac239. Journal of Virology (Print) , v. 88, p. 7493-7516, 2014.

• CONNICK, E. ; FOLKVORD, J. M. ; LIND, K. T. ; RAKASZ, E. G. ; MILES, B. ; WILSON, N. A. ; SANTIAGO, M. L. ; SCHMITT, K. ; STEPHENS, E. B. ; KIM, H. O. ; WAGSTAFF, R. ; LI, S. ; ABDELAAL, H. M. ; KEMP, N. ; WATKINS, D. I. ; MAWHINNEY, S. ; SKINNER, P. J. . Compartmentalization of Simian Immunodeficiency Virus Replication within Secondary Lymphoid Tissues of Rhesus Macaques Is Linked to Disease Stage and Inversely Related to Localization of Virus-Specific CTL. The Journal of Immunology (1950) , v. 193, p. 5613-5625, 2014.

• SANTANA, MARLON G. VELOSO DE ; NEVES, PATRÍCIA C.C. ; SANTOS, JULIANA RIBEIRO DOS ; LIMA, NOEMIA S. ; SANTOS, ALEXANDRE A.C. DOS ; WATKINS, DAVID I. ; GALLER, RICARDO ; BONALDO, MYRNA C. . Improved genetic stability of recombinant yellow fever 17D virus expressing a lentiviral Gag gene fragment. Virology (New York, N.Y. Print) , v. 452-453, p. 202-211, 2014.

• MARTINS, MAURICIO A. ; BONALDO, MYRNA C. ; RUDERSDORF, RICHARD A. ; PIASKOWSKI, SHARI M. ; RAKASZ, EVA G. ; WEISGRAU, KIM L. ; FURLOTT, JESSICA R. ; EERNISSE, CHRISTOPHER M. ; VELOSO DE SANTANA, MARLON G. ; HIDALGO, BERTHA ; FRIEDRICH, THOMAS C. ; CHIUCHIOLO, MARIA J. ; PARKS, CHRISTOPHER L. ; WILSON, NANCY A. ; ALLISON, DAVID B. ; GALLER, RICARDO ; WATKINS, DAVID I. . Immunogenicity of Seven New Recombinant Yellow Fever Viruses 17D Expressing Fragments of SIVmac239 Gag, Nef, and Vif in Indian Rhesus Macaques. Plos One , v. 8, p. e54434, 2013.

• TAROSSO, LEANDRO F. ; SAUER, MARIANA M. ; SANABANI, SABRI ; GIRET, MARIA TERESA ; TOMIYAMA, HELENA I. ; SIDNEY, JOHN ; PIASKOWSKI, SHARI M. ; DIAZ, RICARDO S. ; SABINO, ESTER C. ; SETTE, ALESSANDRO ; KALIL-FILHO, JORGE ; WATKINS, DAVID I. ; KALLAS, ESPER G. . Correction: Unexpected Diversity of Cellular Immune Responses against Nef and Vif in HIV-1-Infected Patients Who Spontaneously Control Viral Replication. Plos One , v. 8, p. 11436, 2013.

• MOLDT, B. ; RAKASZ, E. G. ; SCHULTZ, N. ; CHAN-HUI, P.-Y. ; SWIDEREK, K. ; WEISGRAU, K. L. ; PIASKOWSKI, S. M. ; BERGMAN, Z. ; WATKINS, D. I. ; POIGNARD, P. ; BURTON, D. R. . Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proceedings of the National Academy of Sciences of the United States of America , v. 109, p. 18921-18925, 2012.

• MUDD, PHILIP A. ; MARTINS, MAURICIO A. ; ERICSEN, ADAM J. ; TULLY, DAMIEN C. ; POWER, KAREN A. ; BEAN, ALEX T. ; PIASKOWSKI, SHARI M. ; DUAN, LIJIE ; SEESE, AARON ; GLADDEN, ADRIANNE D. ; WEISGRAU, KIM L. ; FURLOTT, JESSICA R. ; KIM, YOUNG-IL ; VELOSO DE SANTANA, MARLON G. ; RAKASZ, EVA ; III, SAVERIO CAPUANO ; WILSON, NANCY A. ; BONALDO, MYRNA C. ; GALLER, RICARDO ; ALLISON, DAVID B. ; PIATAK JR, MICHAEL ; HAASE, ASHLEY T. ; LIFSON, JEFFREY D. ; ALLEN, TODD M. ; WATKINS, DAVID I. . Vaccine-induced CD8+ T cells control AIDS virus replication. Nature (London) , v. 491, p. 129-133, 2012.

• POIGNARD, PASCAL ; MOLDT, BRIAN ; MALOVESTE, KARLA ; CAMPOS, NOËLIE ; OLSON, WILLIAM C. ; RAKASZ, EVA ; WATKINS, DAVID I. ; BURTON, DENNIS R. . Protection against High-Dose Highly Pathogenic Mucosal SIV Challenge at Very Low Serum Neutralizing Titers of the Antibody-Like Molecule CD4-IgG2. Plos One , v. 7, p. e42209, 2012.

• REYNOLDS, MATTHEW R. ; WEILER, ANDREA M. ; PIASKOWSKI, SHARI M. ; PIATAK, MICHAEL ; ROBERTSON, HENRY T. ; ALLISON, DAVID B. ; BETT, ANDREW J. ; CASIMIRO, DANILO R. ; SHIVER, JOHN W. ; WILSON, NANCY A. ; LIFSON, JEFFREY D. ; KOFF, WAYNE C. ; WATKINS, DAVID I. . A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge. Vaccine (Guildford) , v. 30, p. 4465-4475, 2012.

• DE GROOT, NATASJA G. ; OTTING, NEL ; ROBINSON, JAMES ; BLANCHER, ANTOINE ; LAFONT, BERNARD A. P. ; MARSH, STEVEN G. E. ; O CONNOR, DAVID H. ; SHIINA, TAKASHI ; WALTER, LUTZ ; WATKINS, DAVID I. ; BONTROP, RONALD E. . Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species. Immunogenetics (New York) , v. 64, p. 615-631, 2012.

• MOLDT, B. ; SHIBATA-KOYAMA, M. ; RAKASZ, E. G. ; SCHULTZ, N. ; KANDA, Y. ; DUNLOP, D. C. ; FINSTAD, S. L. ; JIN, C. ; LANDUCCI, G. ; ALPERT, M. D. ; DUGAST, A.-S. ; PARREN, P. W. H. I. ; NIMMERJAHN, F. ; EVANS, D. T. ; ALTER, G. ; FORTHAL, D. N. ; SCHMITZ, J. E. ; IIDA, S. ; POIGNARD, P. ; WATKINS, D. I. ; HESSELL, A. J. ; BURTON, D. R. . A Nonfucosylated Variant of the anti-HIV-1 Monoclonal Antibody b12 Has Enhanced Fc RIIIa-Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques. Journal of Virology (Print) , v. 86, p. 6189-6196, 2012.

• MUDD, P. A. ; ERICSEN, A. J. ; BURWITZ, B. J. ; WILSON, N. A. ; O'CONNOR, D. H. ; HUGHES, A. L. ; WATKINS, D. I. . Escape from CD8+ T Cell Responses in Mamu-B*00801+ Macaques Differentiates Progressors from Elite Controllers. The Journal of Immunology (1950) , v. 188, p. 3364-3370, 2012.

• SETTE, ALESSANDRO ; SIDNEY, JOHN ; SOUTHWOOD, SCOTT ; MOORE, CARRIE ; BERRY, JESSICA ; DOW, COURTNEY ; BRADLEY, KATE ; HOOF, ILKA ; LEWIS, MARK G. ; HILDEBRAND, WILLIAM H. ; MCMURTREY, CURTIS P. ; WILSON, NANCY A. ; WATKINS, DAVID I. ; MOTHÉ, BIANCA R. . A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules. Immunogenetics (New York) , v. 64, p. 421-434, 2012.

• VOJNOV, L. ; MARTINS, M. A. ; BEAN, A. T. ; VELOSO DE SANTANA, M. G. ; SACHA, J. B. ; WILSON, N. A. ; BONALDO, M. C. ; GALLER, R. ; STEVENSON, M. ; WATKINS, D. I. . The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8+ T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages. Journal of Virology (Print) , v. 86, p. 4682-4687, 2012.

• MLADINICH, KATHERINE M. ; PIASKOWSKI, SHARI M. ; RUDERSDORF, RICHARD ; EERNISSE, CHRISTOPHER M. ; WEISGRAU, KIM L. ; MARTINS, MAURICIO A. ; FURLOTT, JESSICA R. ; PARTIDOS, CHARALAMBOS D. ; BREWOO, JOSEPH N. ; OSORIO, JORGE E. ; WILSON, NANCY A. ; RAKASZ, EVA G. ; WATKINS, DAVID I. . Dengue virus-specific CD4+ and CD8+ T lymphocytes target NS1, NS3 and NS5 in infected Indian rhesus macaques. Immunogenetics (New York) , v. 64, p. 111-121, 2012.

• BURWITZ, B. J. ; SACHA, J. B. ; REED, J. S. ; NEWMAN, L. P. ; NORANTE, F. A. ; BIMBER, B. N. ; WILSON, N. A. ; WATKINS, D. I. ; O'CONNOR, D. H. . Pyrosequencing Reveals Restricted Patterns of CD8+ T Cell Escape-Associated Compensatory Mutations in Simian Immunodeficiency Virus. Journal of Virology (Print) , v. 85, p. 13088-13096, 2011.

• MUDD, P. A. ; ERICSEN, A. J. ; WALSH, A. D. ; LEON, E. J. ; WILSON, N. A. ; MANESS, N. J. ; FRIEDRICH, T. C. ; WATKINS, D. I. . CD8+ T Cell Escape Mutations in Simian Immunodeficiency Virus SIVmac239 Cause Fitness Defects In Vivo, and Many Revert after Transmission. Journal of Virology (Print) , v. 85, p. 12804-12810, 2011.

• VOJNOV, LARA ; MARTINS, MAURICIO A. ; ALMEIDA, JORGE R. ; ENDE, ZACHARY ; RAKASZ, EVA G. ; REYNOLDS, MATTHEW R. ; LEON, ENRIQUE J. ; WEISGRAU, KIM L. ; BURWITZ, BENJAMIN J. ; FOLKVORD, JOY M. ; VELOSO DE SANTANA, MARLON G. ; COSTA NEVES, PATRÍCIA C. ; CONNICK, ELIZABETH ; SKINNER, PAMELA J. ; GOSTICK, EMMA ; O'CONNOR, DAVID H. ; WILSON, NANCY A. ; BONALDO, MYRNA C. ; GALLER, RICARDO ; PRICE, DAVID A. ; DOUEK, DANNY C. ; WATKINS, DAVID I. . GagCM9-Specific CD8+ T Cells Expressing Limited Public TCR Clonotypes Do Not Suppress SIV Replication In Vivo. Plos One , v. 6, p. e23515, 2011.

• VOJNOV, LARA ; BEAN, ALEXANDER T. ; PETERSON, ERIC J. ; CHIUCHIOLO, MARIA J. ; SACHA, JONAH B. ; DENES, FERENCZ S. ; SANDOR, MATYAS ; FULLER, DEBORAH H. ; FULLER, JAMES T. ; PARKS, CHRISTOPHER L. ; MCDERMOTT, ADRIAN B. ; WILSON, NANCY A. ; WATKINS, DAVID I. . DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4+ T cells, but few subdominant epitope-specific CD8+ T cells. Vaccine (Guildford) , v. 29, p. 7483-7490, 2011.

• REYNOLDS, M. R. ; SACHA, J. B. ; WEILER, A. M. ; BORCHARDT, G. J. ; GLIDDEN, C. E. ; SHEPPARD, N. C. ; NORANTE, F. A. ; CASTROVINCI, P. A. ; HARRIS, J. J. ; ROBERTSON, H. T. ; FRIEDRICH, T. C. ; MCDERMOTT, A. B. ; WILSON, N. A. ; ALLISON, D. B. ; KOFF, W. C. ; JOHNSON, W. E. ; WATKINS, D. I. . The TRIM5  Genotype of Rhesus Macaques Affects Acquisition of Simian Immunodeficiency Virus SIVsmE660 Infection after Repeated Limiting-Dose Intrarectal Challenge. Journal of Virology (Print) , v. 85, p. 9637-9640, 2011.

• REED, JASON S. ; SIDNEY, JOHN ; PIASKOWSKI, SHARI M. ; GLIDDEN, CHRYSTAL E. ; LEÓN, ENRIQUE J. ; BURWITZ, BENJAMIN J. ; KOLAR, HOLLY L. ; EERNISSE, CHRISTOPHER M. ; FURLOTT, JESSICA R. ; MANESS, NICHOLAS J. ; WALSH, ANDREW D. ; RUDERSDORF, RICHARD A. ; BARDET, WILFRIED ; MCMURTREY, CURTIS P. ; O CONNOR, DAVID H. ; HILDEBRAND, WILLIAM H. ; SETTE, ALESSANDRO ; WATKINS, DAVID I. ; WILSON, NANCY A. . The role of MHC class I allele Mamu-A*07 during SIVmac239 infection. Immunogenetics (New York) , v. 63, p. 789-807, 2011.

• MANESS, NICHOLAS JAMES ; WALSH, ANDREW D. ; RUDERSDORF, RICHARD A. ; ERICKSON, PRISCILLA A. ; PIASKOWSKI, SHARI M. ; WILSON, NANCY A. ; WATKINS, DAVID I. . Chinese origin rhesus macaque major histocompatibility complex class I molecules promiscuously present epitopes from SIV associated with molecules of Indian origin; implications for immunodominance and viral escape. Immunogenetics (New York) , v. 63, p. 587-597, 2011.

• MUDD, P. A. ; ERICSEN, A. J. ; PRICE, A. A. ; WILSON, N. A. ; REIMANN, K. A. ; WATKINS, D. I. . Reduction of CD4+ T Cells In Vivo Does Not Affect Virus Load in Macaque Elite Controllers. Journal of Virology (Print) , v. 85, p. 7454-7459, 2011.

• MUDD, PHILIP A ; WATKINS, DAVID I . Understanding animal models of elite control: windows on effective immune responses against immunodeficiency viruses. Current Opinion in HIV and AIDS (Print) , v. 6, p. 197-201, 2011.

• NEVES, PATRÍCIA C.C. ; RUDERSDORF, RICHARD A. ; GALLER, RICARDO ; BONALDO, MYRNA C. ; SANTANA, MARLON GILSEPP VELOSO DE ; MUDD, PHILIP A. ; MARTINS, MAURÍCIO A. ; RAKASZ, EVA G. ; WILSON, NANCY A. ; WATKINS, DAVID I. . CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses. Vaccine (Guildford) , v. 28, p. 8183-8188, 2010.

• GIRALDO-VELA, JUAN P. ; BEAN, ALEX T. ; RUDERSDORF, RICHARD ; WALLACE, LYLE T. ; LOFFREDO, JOHN T. ; ERICKSON, PRISCILLA ; WILSON, NANCY A. ; WATKINS, DAVID I. . Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid. Immunogenetics (New York) , v. 62, p. 701-707, 2010.

• MANESS, N. J. ; WALSH, A. D. ; PIASKOWSKI, S. M. ; FURLOTT, J. ; KOLAR, H. L. ; BEAN, A. T. ; WILSON, N. A. ; WATKINS, D. I. . CD8+ T Cell Recognition of Cryptic Epitopes Is a Ubiquitous Feature of AIDS Virus Infection. Journal of Virology (Print) , v. 84, p. 11569-11574, 2010.

• SACHA, J. B. ; BUECHLER, M. B. ; NEWMAN, L. P. ; REED, J. ; WALLACE, L. T. ; LOFFREDO, J. T. ; WILSON, N. A. ; WATKINS, D. I. . Simian Immunodeficiency Virus-Specific CD8+ T Cells Recognize Vpr- and Rev-Derived Epitopes Early after Infection. Journal of Virology (Print) , v. 84, p. 10907-10912, 2010.

• MUDD, PHILIP A. ; PIASKOWSKI, SHARI M. ; NEVES, PATRICIA C. COSTA ; RUDERSDORF, RICHARD ; KOLAR, HOLLY L. ; EERNISSE, CHRISTOPHER M. ; WEISGRAU, KIM L. ; SANTANA, MARLON G. VELOSO ; WILSON, NANCY A. ; BONALDO, MYRNA C. ; GALLER, RICARDO ; RAKASZ, EVA G. ; WATKINS, DAVID I. . The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques-implications for recombinant vaccine design. Immunogenetics (New York) , v. 62, p. 593-600, 2010.

• REYNOLDS, M. R. ; WEILER, A. M. ; PIASKOWSKI, S. M. ; KOLAR, H. L. ; HESSELL, A. J. ; WEIKER, M. ; WEISGRAU, K. L. ; LEON, E. J. ; ROGERS, W. E. ; MAKOWSKY, R. ; MCDERMOTT, A. B. ; BOYLE, R. ; WILSON, N. A. ; ALLISON, D. B. ; BURTON, D. R. ; KOFF, W. C. ; WATKINS, D. I. . Macaques Vaccinated with Simian Immunodeficiency Virus SIVmac239 nef Delay Acquisition and Control Replication after Repeated Low-Dose Heterologous SIV Challenge. Journal of Virology (Print) , v. 84, p. 9190-9199, 2010.

• MARTINS, M. A. ; WILSON, N. A. ; REED, J. S. ; AHN, C. D. ; KLIMENTIDIS, Y. C. ; ALLISON, D. B. ; WATKINS, D. I. . T-Cell Correlates of Vaccine Efficacy after a Heterologous Simian Immunodeficiency Virus Challenge. Journal of Virology (Print) , v. 84, p. 4352-4365, 2010.

• SACHA, JONAH B ; WATKINS, DAVID I . Synchronous infection of SIV and HIV in vitro for virology, immunology and vaccine-related studies. Nature Protocols (Print) , v. 5, p. 239-246, 2010.

• BONALDO, M. C. ; MARTINS, M. A. ; RUDERSDORF, R. ; MUDD, P. A. ; SACHA, J. B. ; PIASKOWSKI, S. M. ; COSTA NEVES, P. C. ; VELOSO DE SANTANA, M. G. ; VOJNOV, L. ; CAPUANO, S. ; RAKASZ, E. G. ; WILSON, N. A. ; FULKERSON, J. ; SADOFF, J. C. ; WATKINS, D. I. ; GALLER, R. . Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus Macaques. Journal of Virology (Print) , v. 84, p. 3699-3706, 2010.

• CASIMIRO, D. R. ; COX, K. ; TANG, A. ; SYKES, K. J. ; FENG, M. ; WANG, F. ; BETT, A. ; SCHLEIF, W. A. ; LIANG, X. ; FLYNN, J. ; TOBERY, T. W. ; WILSON, K. ; FINNEFROCK, A. ; HUANG, L. ; VITELLI, S. ; LIN, J. ; PATEL, D. ; DAVIES, M.-E. ; HEIDECKER, G. J. ; FREED, D. C. ; DUBEY, S. ; O'CONNOR, D. H. ; WATKINS, D. I. ; ZHANG, Z.-Q. ; SHIVER, J. W. . Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge. Journal of Virology (Print) , v. 84, p. 2996-3003, 2010.

• HESSELL, A. J. ; RAKASZ, E. G. ; TEHRANI, D. M. ; HUBER, M. ; WEISGRAU, K. L. ; LANDUCCI, G. ; FORTHAL, D. N. ; KOFF, W. C. ; POIGNARD, P. ; WATKINS, D. I. ; BURTON, D. R. . Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L. Journal of Virology (Print) , v. 84, p. 1302-1313, 2010.

• SILVA, MARCIO DE OLIVEIRA ; BASTOS, MILENA ; MARTINS NETTO, EDUARDO ; GOUVEA, NANCY ALVES DE LIMA ; TORRES, ALEX JOSE LEITE ; KALLAS, ESPER ; WATKINS, DAVID I ; ALTFELD, MARCUS ; BRITES, CARLOS . Acute HIV infection with rapid progression to AIDS. The Brazilian Journal of Infectious Diseases (Impresso) , v. 14, p. 291-293, 2010.

• MANESS, N. J. ; WILSON, N. A. ; REED, J. S. ; PIASKOWSKI, S. M. ; SACHA, J. B. ; WALSH, A. D. ; THORYK, E. ; HEIDECKER, G. J. ; CITRON, M. P. ; LIANG, X. ; BETT, A. J. ; CASIMIRO, D. R. ; WATKINS, D. I. . Robust, Vaccine-Induced CD8+ T Lymphocyte Response against an Out-of-Frame Epitope. The Journal of Immunology (1950) , v. 184, p. 67-72, 2009.

• VOJNOV, L. ; REED, J. S. ; WEISGRAU, K. L. ; RAKASZ, E. G. ; LOFFREDO, J. T. ; PIASKOWSKI, S. M. ; SACHA, J. B. ; KOLAR, H. L. ; WILSON, N. A. ; JOHNSON, R. P. ; WATKINS, D. I. . Effective Simian Immunodeficiency Virus-Specific CD8+ T Cells Lack an Easily Detectable, Shared Characteristic. Journal of Virology (Print) , v. 84, p. 753-764, 2009.

• VALENTINE, L. E. ; LOFFREDO, J. T. ; BEAN, A. T. ; LEON, E. J. ; MACNAIR, C. E. ; BEAL, D. R. ; PIASKOWSKI, S. M. ; KLIMENTIDIS, Y. C. ; LANK, S. M. ; WISEMAN, R. W. ; WEINFURTER, J. T. ; MAY, G. E. ; RAKASZ, E. G. ; WILSON, N. A. ; FRIEDRICH, T. C. ; O'CONNOR, D. H. ; ALLISON, D. B. ; WATKINS, D. I. . Infection with 'Escaped' Virus Variants Impairs Control of Simian Immunodeficiency Virus SIVmac239 Replication in Mamu-B*08-Positive Macaques. Journal of Virology (Print) , v. 83, p. 11514-11527, 2009.

• MANESS, N. J. ; SACHA, J. B. ; PIASKOWSKI, S. M. ; WEISGRAU, K. L. ; RAKASZ, E. G. ; MAY, G. E. ; BUECHLER, M. B. ; WALSH, A. D. ; WILSON, N. A. ; WATKINS, D. I. . Novel Translation Products from Simian Immunodeficiency Virus SIVmac239 Env-Encoding mRNA Contain both Rev and Cryptic T-Cell Epitopes. Journal of Virology (Print) , v. 83, p. 10280-10285, 2009.

• LOFFREDO, J. T. ; SIDNEY, J. ; BEAN, A. T. ; BEAL, D. R. ; BARDET, W. ; WAHL, A. ; HAWKINS, O. E. ; PIASKOWSKI, S. ; WILSON, N. A. ; HILDEBRAND, W. H. ; WATKINS, D. I. ; SETTE, A. . Two MHC Class I Molecules Associated with Elite Control of Immunodeficiency Virus Replication, Mamu-B*08 and HLA-B*2705, Bind Peptides with Sequence Similarity. The Journal of Immunology (1950) , v. 182, p. 7763-7775, 2009.

• SACHA, J. B. ; GIRALDO-VELA, J. P. ; BUECHLER, M. B. ; MARTINS, M. A. ; MANESS, N. J. ; CHUNG, C. ; WALLACE, L. T. ; LEON, E. J. ; FRIEDRICH, T. C. ; WILSON, N. A. ; HIRAOKA, A. ; WATKINS, D. I. . Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection. Proceedings of the National Academy of Sciences of the United States of America , v. 106, p. 9791-9796, 2009.

• HESSELL, ANN J. ; RAKASZ, EVA G. ; POIGNARD, PASCAL ; HANGARTNER, LARS ; LANDUCCI, GARY ; FORTHAL, DONALD N. ; KOFF, WAYNE C. ; WATKINS, DAVID I. ; BURTON, DENNIS R. . Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers. PLoS Pathogens (Online) , v. 5, p. e1000433, 2009.

• WILSON, N. A. KEELE, B. F. REED, J. S. PIASKOWSKI, S. M. MACNAIR, C. E. BETT, A. J. LIANG, X. WANG, F. THORYK, E. HEIDECKER, G. J. CITRON, M. P. HUANG, L. LIN, J. VITELLI, S. AHN, C. D. KAIZU, M. MANESS, N. J. REYNOLDS, M. R. FRIEDRICH, T. C. LOFFREDO, J. T. RAKASZ, E. G. ERICKSON, S. ALLISON, D. B. PIATAK, M. LIFSON, J. D. , et al. SHIVER, J. W. CASIMIRO, D. R. SHAW, G. M. HAHN, B. H. WATKINS, D. I. ; Vaccine-Induced Cellular Responses Control Simian Immunodeficiency Virus Replication after Heterologous Challenge. Journal of Virology (Print) , v. 83, p. 6508-6521, 2009.

• HONG, JUNG JOO ; REYNOLDS, MATTHEW R. ; MATTILA, TERESA L. ; HAGE, AARON ; WATKINS, DAVID I. ; MILLER, CHRISTOPHER J. ; SKINNER, PAMELA J. . Localized Populations of CD8low/− MHC Class I Tetramer+ SIV-Specific T Cells in Lymphoid Follicles and Genital Epithelium. Plos One , v. 4, p. e4131, 2009.

• WILSON, NANCY A. ; WATKINS, DAVID I. . Is an HIV vaccine possible?. The Brazilian Journal of Infectious Diseases (Impresso) , v. 13, p. 304, 2009.

• FRIEDRICH, THOMAS C ; WATKINS, DAVID I . Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus. Current Opinion in HIV and AIDS (Print) , v. 3, p. 393-398, 2008.

• VALENTINE, LAURA E. ; WATKINS, DAVID I. . Relevance of studying T cell responses in SIV-infected rhesus macaques. Trends in Microbiology (Regular Ed.) , v. 16, p. 605-611, 2008.

• REYNOLDS, M. R. ; WEILER, A. M. ; WEISGRAU, K. L. ; PIASKOWSKI, S. M. ; FURLOTT, J. R. ; WEINFURTER, J. T. ; KAIZU, M. ; SOMA, T. ; LEON, E. J. ; MACNAIR, C. ; LEAMAN, D. P. ; ZWICK, M. B. ; GOSTICK, E. ; MUSANI, S. K. ; PRICE, D. A. ; FRIEDRICH, T. C. ; RAKASZ, E. G. ; WILSON, N. A. ; MCDERMOTT, A. B. ; BOYLE, R. ; ALLISON, D. B. ; BURTON, D. R. ; KOFF, W. C. ; WATKINS, D. I. . Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. The Journal of Experimental Medicine , v. 205, p. 2537-2550, 2008.

• FAUCI, A. S. ; JOHNSTON, M. I. ; DIEFFENBACH, C. W. ; BURTON, D. R. ; HAMMER, S. M. ; HOXIE, J. A. ; MARTIN, M. ; OVERBAUGH, J. ; WATKINS, D. I. ; MAHMOUD, A. ; GREENE, W. C. . HIV Vaccine Research: The Way Forward. Science (New York, N.Y.) , v. 321, p. 530-532, 2008.

• GOULDER, PHILIP J. R. ; WATKINS, DAVID I. . Impact of MHC class I diversity on immune control of immunodeficiency virus replication. Nature Reviews. Immunology (Print) , v. 8, p. 619-630, 2008.

• SACHA, J. B. ; REYNOLDS, M. R. ; BUECHLER, M. B. ; CHUNG, C. ; JONAS, A. K. ; WALLACE, L. T. ; WEILER, A. M. ; LEE, W. ; PIASKOWSKI, S. M. ; SOMA, T. ; FRIEDRICH, T. C. ; WILSON, N. A. ; WATKINS, D. I. . Differential Antigen Presentation Kinetics of CD8+ T-Cell Epitopes Derived from the Same Viral Protein. Journal of Virology (Print) , v. 82, p. 9293-9298, 2008.

• WATKINS, DAVID I ; BURTON, DENNIS R ; KALLAS, ESPER G ; MOORE, JOHN P ; KOFF, WAYNE C . Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans. Nature Medicine (Print) , v. 14, p. 617-621, 2008.

• MANESS, N. J. ; YANT, L. J. ; CHUNG, C. ; LOFFREDO, J. T. ; FRIEDRICH, T. C. ; PIASKOWSKI, S. M. ; FURLOTT, J. ; MAY, G. E. ; SOMA, T. ; LEON, E. J. ; WILSON, N. A. ; PIONTKIVSKA, H. ; HUGHES, A. L. ; SIDNEY, J. ; SETTE, A. ; WATKINS, D. I. . Comprehensive Immunological Evaluation Reveals Surprisingly Few Differences between Elite Controller and Progressor Mamu-B*17-Positive Simian Immunodeficiency Virus-Infected Rhesus Macaques. Journal of Virology (Print) , v. 82, p. 5245-5254, 2008.

• WATKINS, DAVID I. . The Vaccine Search Goes On. Scientific American , v. 299, p. 69-76, 2008.

• WATKINS, DAVID I . The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review. Memórias do Instituto Oswaldo Cruz (Impresso) , v. 103, p. 119-129, 2008.

• LOFFREDO, J. T. ; BEAN, A. T. ; BEAL, D. R. ; LEON, E. J. ; MAY, G. E. ; PIASKOWSKI, S. M. ; FURLOTT, J. R. ; REED, J. ; MUSANI, S. K. ; RAKASZ, E. G. ; FRIEDRICH, T. C. ; WILSON, N. A. ; ALLISON, D. B. ; WATKINS, D. I. . Patterns of CD8+ Immunodominance May Influence the Ability of Mamu-B*08-Positive Macaques To Naturally Control Simian Immunodeficiency Virus SIVmac239 Replication. Journal of Virology (Print) , v. 82, p. 1723-1738, 2008.

• LOFFREDO, JOHN T. ; FRIEDRICH, THOMAS C. ; LEÓN, ENRIQUE J. ; STEPHANY, JASON J. ; RODRIGUES, DENISE S. ; SPENCER, SEAN P. ; BEAN, ALEX T. ; BEAL, DOMINIC R. ; BURWITZ, BENJAMIN J. ; RUDERSDORF, RICHARD A. ; WALLACE, LYLE T. ; PIASKOWSKI, SHARI M. ; MAY, GEMMA E. ; SIDNEY, JOHN ; GOSTICK, EMMA ; WILSON, NANCY A. ; PRICE, DAVID A. ; KALLAS, ESPER G. ; PIONTKIVSKA, HELEN ; HUGHES, AUSTIN L. ; SETTE, ALESSANDRO ; WATKINS, DAVID I. . CD8+ T Cells from SIV Elite Controller Macaques Recognize Mamu-B*08-Bound Epitopes and Select for Widespread Viral Variation. Plos One , v. 2, p. e1152, 2007.

• VALENTINE, L. E. ; PIASKOWSKI, S. M. ; RAKASZ, E. G. ; HENRY, N. L. ; WILSON, N. A. ; WATKINS, D. I. . Recognition of Escape Variants in ELISPOT Does Not Always Predict CD8+ T-Cell Recognition of Simian Immunodeficiency Virus-Infected Cells Expressing the Same Variant Sequences. Journal of Virology (Print) , v. 82, p. 575-581, 2007.

• MANESS, N. J. ; VALENTINE, L. E. ; MAY, G. E. ; REED, J. ; PIASKOWSKI, S. M. ; SOMA, T. ; FURLOTT, J. ; RAKASZ, E. G. ; FRIEDRICH, T. C. ; PRICE, D. A. ; GOSTICK, E. ; HUGHES, A. L. ; SIDNEY, J. ; SETTE, A. ; WILSON, N. A. ; WATKINS, D. I. . AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape. The Journal of Experimental Medicine , v. 204, p. 2505-2512, 2007.

• SACHA, J. B. ; CHUNG, C. ; REED, J. ; JONAS, A. K. ; BEAN, A. T. ; SPENCER, S. P. ; LEE, W. ; VOJNOV, L. ; RUDERSDORF, R. ; FRIEDRICH, T. C. ; WILSON, N. A. ; LIFSON, J. D. ; WATKINS, D. I. . Pol-Specific CD8+ T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation. Journal of Virology (Print) , v. 81, p. 11703-11712, 2007.

• KAIZU, MASAHIKO ; BORCHARDT, GRETTA J. ; GLIDDEN, CHRYSTAL E. ; FISK, DEBRA L. ; LOFFREDO, JOHN T. ; WATKINS, DAVID I. ; REHRAUER, WILLIAM M. . Molecular typing of major histocompatibility complex class I alleles in the Indian rhesus macaque which restrict SIV CD8+ T cell epitopes. Immunogenetics (New York) , v. 59, p. 693-703, 2007.

• QUEIROZ, ARTUR TRANCOSO LOPO DE ; SANTOS, LUCIANE AMORIM ; MOREAU, DOMINGOS RAMON ; OLIVEIRA, TULIO DE ; WATKINS, DAVID I. ; GALVÃO-CASTRO, BERNARDO ; ALCANTARA, LUIZ CARLOS JUNIOR . Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil. The Brazilian Journal of Infectious Diseases (Impresso) , v. 11, p. 27-30, 2007.

• LOFFREDO, J. T. ; MAXWELL, J. ; QI, Y. ; GLIDDEN, C. E. ; BORCHARDT, G. J. ; SOMA, T. ; BEAN, A. T. ; BEAL, D. R. ; WILSON, N. A. ; REHRAUER, W. M. ; LIFSON, J. D. ; CARRINGTON, M. ; WATKINS, D. I. . Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication. Journal of Virology (Print) , v. 81, p. 8827-8832, 2007.

• FULLER, DEBORAH HEYDENBURG ; SHIPLEY, TIM ; ALLEN, TODD M. ; FULLER, JAMES T. ; WU, MARY S. ; HORTON, HELEN ; WILSON, NANCY ; WIDERA, GEORG ; WATKINS, DAVID I. . Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques. Virology (New York, N.Y. Print) , v. 364, p. 245-255, 2007.

• KAWADA, M. ; TSUKAMOTO, T. ; YAMAMOTO, H. ; TAKEDA, A. ; IGARASHI, H. ; WATKINS, D. I. ; MATANO, T. . Long-Term Control of Simian Immunodeficiency Virus Replication with Central Memory CD4+ T-Cell Preservation after Nonsterile Protection by a Cytotoxic T-Lymphocyte-Based Vaccine. Journal of Virology (Print) , v. 81, p. 5202-5211, 2007.

• SACHA, J. B. ; CHUNG, C. ; RAKASZ, E. G. ; SPENCER, S. P. ; JONAS, A. K. ; BEAN, A. T. ; LEE, W. ; BURWITZ, B. J. ; STEPHANY, J. J. ; LOFFREDO, J. T. ; ALLISON, D. B. ; ADNAN, S. ; HOJI, A. ; WILSON, N. A. ; FRIEDRICH, T. C. ; LIFSON, J. D. ; YANG, O. O. ; WATKINS, D. I. . Gag-Specific CD8+ T Lymphocytes Recognize Infected Cells before AIDS-Virus Integration and Viral Protein Expression. The Journal of Immunology (1950) , v. 178, p. 2746-2754, 2007.

• FRIEDRICH, T. C. ; VALENTINE, L. E. ; YANT, L. J. ; RAKASZ, E. G. ; PIASKOWSKI, S. M. ; FURLOTT, J. R. ; WEISGRAU, K. L. ; BURWITZ, B. ; MAY, G. E. ; LEON, E. J. ; SOMA, T. ; NAPOE, G. ; CAPUANO, S. V. ; WILSON, N. A. ; WATKINS, D. I. . Subdominant CD8+ T-Cell Responses Are Involved in Durable Control of AIDS Virus Replication. Journal of Virology (Print) , v. 81, p. 3465-3476, 2007.

• LOFFREDO, J. T. ; BURWITZ, B. J. ; RAKASZ, E. G. ; SPENCER, S. P. ; STEPHANY, J. J. ; GIRALDO VELA, J. P. ; MARTIN, S. R. ; REED, J. ; PIASKOWSKI, S. M. ; FURLOTT, J. ; WEISGRAU, K. L. ; RODRIGUES, D. S. ; SOMA, T. ; NAPOE, G. ; FRIEDRICH, T. C. ; WILSON, N. A. ; KALLAS, E. G. ; WATKINS, D. I. . The Antiviral Efficacy of Simian Immunodeficiency Virus-Specific CD8+ T Cells Is Unrelated to Epitope Specificity and Is Abrogated by Viral Escape. Journal of Virology (Print) , v. 81, p. 2624-2634, 2007.

• CHUNG, C. ; LEE, W. ; LOFFREDO, J. T. ; BURWITZ, B. ; FRIEDRICH, T. C. ; GIRALDO VELA, J. P. ; NAPOE, G. ; RAKASZ, E. G. ; WILSON, N. A. ; ALLISON, D. B. ; WATKINS, D. I. . Not All Cytokine-Producing CD8+ T Cells Suppress Simian Immunodeficiency Virus Replication. Journal of Virology (Print) , v. 81, p. 1517-1523, 2007.

• WEILER, ANDREA ; MAY, GEMMA E. ; QI, YING ; WILSON, NANCY ; WATKINS, DAVID I. . Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques. Immunogenetics (New York) , v. 58, p. 1003-1009, 2006.

• BOYER, JEAN D. ; KUMAR, SANJEEV ; ROBINSON, TARA ; PARKINSON, ROSE ; WU, LING ; LEWIS, MARK ; WATKINS, DAVID I. ; WEINER, DAVID B. . Initiation of antiretroviral therapy during chronic SIV infection leads to rapid reduction in viral loads and the level of T-cell immune response. Journal of Medical Primatology , v. 35, p. 202-209, 2006.

• WILSON, N. A. REED, J. NAPOE, G. S. PIASKOWSKI, S. SZYMANSKI, A. FURLOTT, J. GONZALEZ, E. J. YANT, L. J. MANESS, N. J. MAY, G. E. SOMA, T. REYNOLDS, M. R. RAKASZ, E. RUDERSDORF, R. MCDERMOTT, A. B. O'CONNOR, D. H. FRIEDRICH, T. C. ALLISON, D. B. PATKI, A. PICKER, L. J. BURTON, D. R. LIN, J. HUANG, L. PATEL, D. HEINDECKER, G. , et al. FAN, J. CITRON, M. HORTON, M. WANG, F. LIANG, X. SHIVER, J. W. CASIMIRO, D. R. WATKINS, D. I. ; Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239. Journal of Virology (Print) , v. 80, p. 5875-5885, 2006.

• YANT, L. J. ; FRIEDRICH, T. C. ; JOHNSON, R. C. ; MAY, G. E. ; MANESS, N. J. ; ENZ, A. M. ; LIFSON, J. D. ; O'CONNOR, D. H. ; CARRINGTON, M. ; WATKINS, D. I. . The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication. Journal of Virology (Print) , v. 80, p. 5074-5077, 2006.

• ESTES, JACOB D. ; LI, QINGSHENG ; REYNOLDS, MATTHEW R. ; WIETGREFE, STEPHEN ; DUAN, LIJIE ; SCHACKER, TIMOTHY ; PICKER, LOUIS J. ; WATKINS, DAVID I. ; LIFSON, JEFFREY D. ; REILLY, CAVAN ; CARLIS, JOHN ; HAASE, ASHLEY T. . Premature Induction of an Immunosuppressive Regulatory T Cell Response during Acute Simian Immunodeficiency Virus Infection. The Journal of Infectious Diseases , v. 193, p. 703-712, 2006.

• MCDERMOTT, A. B. ; O'CONNOR, D. H. ; FUENGER, S. ; PIASKOWSKI, S. ; MARTIN, S. ; LOFFREDO, J. ; REYNOLDS, M. ; REED, J. ; FURLOTT, J. ; JACOBY, T. ; RIEK, C. ; DODDS, E. ; KREBS, K. ; DAVIES, M.-E. ; SCHLEIF, W. A. ; CASIMIRO, D. R. ; SHIVER, J. W. ; WATKINS, D. I. . Cytotoxic T-Lymphocyte Escape Does Not Always Explain the Transient Control of Simian Immunodeficiency Virus SIVmac239 Viremia in Adenovirus-Boosted and DNA-Primed Mamu-A*01-Positive Rhesus Macaques. Journal of Virology (Print) , v. 79, p. 15556-15566, 2005.

• CASIMIRO, D. R. WANG, F. SCHLEIF, W. A. LIANG, X. ZHANG, Z.-Q. TOBERY, T. W. DAVIES, M.-E. MCDERMOTT, A. B. O'CONNOR, D. H. FRIDMAN, A. BAGCHI, A. TUSSEY, L. G. BETT, A. J. FINNEFROCK, A. C. FU, T.-M. TANG, A. WILSON, K. A. CHEN, M. PERRY, H. C. HEIDECKER, G. J. FREED, D. C. CARELLA, A. PUNT, K. S. SYKES, K. J. HUANG, L. , et al. AUSENSI, V. I. BACHINSKY, M. SADASIVAN-NAIR, U. WATKINS, D. I. EMINI, E. A. SHIVER, J. W. ; Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag. Journal of Virology (Print) , v. 79, p. 15547-15555, 2005.

• LOFFREDO, J. T. ; RAKASZ, E. G. ; GIRALDO, J. P. ; SPENCER, S. P. ; GRAFTON, K. K. ; MARTIN, S. R. ; NAPOE, G. ; YANT, L. J. ; WILSON, N. A. ; WATKINS, D. I. . Tat28-35SL8-Specific CD8+ T Lymphocytes Are More Effective than Gag181-189CM9-Specific CD8+ T Lymphocytes at Suppressing Simian Immunodeficiency Virus Replication in a Functional In Vitro Assay. Journal of Virology (Print) , v. 79, p. 14986-14991, 2005.

• LOFFREDO, J. T. ; SIDNEY, J. ; PIASKOWSKI, S. ; SZYMANSKI, A. ; FURLOTT, J. ; RUDERSDORF, R. ; REED, J. ; PETERS, B. ; HICKMAN-MILLER, H. D. ; BARDET, W. ; REHRAUER, W. M. ; O'CONNOR, D. H. ; WILSON, N. A. ; HILDEBRAND, W. H. ; SETTE, A. ; WATKINS, D. I. . The High Frequency Indian Rhesus Macaque MHC Class I Molecule, Mamu-B*01, Does Not Appear to Be Involved in CD8+ T Lymphocyte Responses to SIVmac239. The Journal of Immunology (1950) , v. 175, p. 5986-5997, 2005.

• PETERS, B. ; BUI, H.-H. ; SIDNEY, J. ; WENG, Z. ; LOFFREDO, J.T. ; WATKINS, D.I. ; MOTHÉ, B.R. ; SETTE, A. . A computational resource for the prediction of peptide binding to Indian rhesus macaque MHC class I molecules. Vaccine (Guildford) , v. 23, p. 5212-5224, 2005.

• SMITH, MIRANDA Z. ; FERNANDEZ, CAROLINE S. ; CHUNG, AMY ; JANE DALE, C. ; ROSE, ROBERT DE ; LIN, JIE ; BROOKS, ANDREW G. ; KREBS, KENDALL C. ; WATKINS, DAVID I. ; O'CONNOR, DAVID H. ; DAVENPORT, MILES P. ; KENT, STEPHEN J. . The pigtail macaque MHC class I allele * presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion. Journal of Medical Primatology , v. 34, p. 282-293, 2005.

• REYNOLDS, M. R. ; RAKASZ, E. ; SKINNER, P. J. ; WHITE, C. ; ABEL, K. ; MA, Z.-M. ; COMPTON, L. ; NAPOE, G. ; WILSON, N. ; MILLER, C. J. ; HAASE, A. ; WATKINS, D. I. . CD8+ T-Lymphocyte Response to Major Immunodominant Epitopes after Vaginal Exposure to Simian Immunodeficiency Virus: Too Late and Too Little. Journal of Virology (Print) , v. 79, p. 9228-9235, 2005.

• HICKMAN-MILLER, H. D. ; BARDET, W. ; GILB, A. ; LUIS, A. D. ; JACKSON, K. W. ; WATKINS, D. I. ; HILDEBRAND, W. H. . Rhesus Macaque MHC Class I Molecules Present HLA-B-Like Peptides. The Journal of Immunology (1950) , v. 175, p. 367-375, 2005.

• BUI, HUYNH-HOA ; SIDNEY, JOHN ; PETERS, BJOERN ; SATHIAMURTHY, MUTHURAMAN ; SINICHI, ASABE ; PURTON, KELLY-ANNE ; MOTHÉ, BIANCA R. ; CHISARI, FRANCIS V. ; WATKINS, DAVID I. ; SETTE, ALESSANDRO . Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications. Immunogenetics (New York) , v. 57, p. 304-314, 2005.

• FERNANDEZ, C. S. ; STRATOV, I. ; DE ROSE, R. ; WALSH, K. ; DALE, C. J. ; SMITH, M. Z. ; AGY, M. B. ; HU, S.-L. ; KREBS, K. ; WATKINS, D. I. ; O'CONNOR, D. H. ; DAVENPORT, M. P. ; KENT, S. J. . Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost. Journal of Virology (Print) , v. 79, p. 5721-5731, 2005.

• BONTROP, RONALD E. ; WATKINS, DAVID I. . MHC polymorphism: AIDS susceptibility in non-human primates. Trends in Immunology (Print) , v. 26, p. 227-233, 2005.

• SETTE, ALESSANDRO ; SIDNEY, JOHN ; BUI, HUYNH-HOA ; GUERCIO, MARIE-FRANCE ; ALEXANDER, JEFF ; LOFFREDO, JOHN ; WATKINS, DAVID I. ; MOTH', BIANCA R. . Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity. Immunogenetics (New York) , v. 57, p. 53-68, 2005.

• OTTING, N. ; HEIJMANS, C. M. C. ; NOORT, R. C. ; DE GROOT, N. G. ; DOXIADIS, G. G. M. ; VAN ROOD, J. J. ; WATKINS, D. I. ; BONTROP, R. E. . Unparalleled complexity of the MHC class I region in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America , v. 102, p. 1626-1631, 2005.

• SMITH, M. Z. ; DALE, C. J. ; DE ROSE, R. ; STRATOV, I. ; FERNANDEZ, C. S. ; BROOKS, A. G. ; WEINFURTER, J. ; KREBS, K. ; RIEK, C. ; WATKINS, D. I. ; O'CONNOR, D. H. ; KENT, S. J. . Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes. Journal of Virology (Print) , v. 79, p. 684-695, 2004.

• O'CONNOR, D. H. ; MCDERMOTT, A. B. ; KREBS, K. C. ; DODDS, E. J. ; MILLER, J. E. ; GONZALEZ, E. J. ; JACOBY, T. J. ; YANT, L. ; PIONTKIVSKA, H. ; PANTOPHLET, R. ; BURTON, D. R. ; REHRAUER, W. M. ; WILSON, N. ; HUGHES, A. L. ; WATKINS, D. I. . A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation. Journal of Virology (Print) , v. 78, p. 14012-14022, 2004.

• LOFFREDO, J. T. ; SIDNEY, J. ; WOJEWODA, C. ; DODDS, E. ; REYNOLDS, M. R. ; NAPOE, G. ; MOTHE, B. R. ; O'CONNOR, D. H. ; WILSON, N. A. ; WATKINS, D. I. ; SETTE, A. . Identification of Seventeen New Simian Immunodeficiency Virus-Derived CD8+ T Cell Epitopes Restricted by the High Frequency Molecule, Mamu-A*02, and Potential Escape from CTL Recognition. The Journal of Immunology (1950) , v. 173, p. 5064-5076, 2004.

• FRIEDRICH, T. C. ; MCDERMOTT, A. B. ; REYNOLDS, M. R. ; PIASKOWSKI, S. ; FUENGER, S. ; DE SOUZA, I. P. ; RUDERSDORF, R. ; CULLEN, C. ; YANT, L. J. ; VOJNOV, L. ; STEPHANY, J. ; MARTIN, S. ; O'CONNOR, D. H. ; WILSON, N. ; WATKINS, D. I. . Consequences of Cytotoxic T-Lymphocyte Escape: Common Escape Mutations in Simian Immunodeficiency Virus Are Poorly Recognized in Naive Hosts. Journal of Virology (Print) , v. 78, p. 10064-10073, 2004.

• GOULDER, PHILIP J. R. ; WATKINS, DAVID I. . HIV and SIV CTL escape: implications for vaccine design. Nature Reviews. Immunology (Print) , v. 4, p. 630-640, 2004.

• MCDERMOTT, A. B. ; MITCHEN, J. ; PIASKOWSKI, S. ; DE SOUZA, I. ; YANT, L. J. ; STEPHANY, J. ; FURLOTT, J. ; WATKINS, D. I. . Repeated Low-Dose Mucosal Simian Immunodeficiency Virus SIVmac239 Challenge Results in the Same Viral and Immunological Kinetics as High-Dose Challenge: a Model for the Evaluation of Vaccine Efficacy in Nonhuman Primates. Journal of Virology (Print) , v. 78, p. 3140-3144, 2004.

• FRIEDRICH, THOMAS C ; DODDS, ELIZABETH J ; YANT, LEVI J ; VOJNOV, LARA ; RUDERSDORF, RICHARD ; CULLEN, CANDICE ; EVANS, DAVID T ; DESROSIERS, RONALD C ; MOTHÉ, BIANCA R ; SIDNEY, JOHN ; SETTE, ALESSANDRO ; KUNSTMAN, KEVIN ; WOLINSKY, STEVEN ; PIATAK, MICHAEL ; LIFSON, JEFFREY ; HUGHES, AUSTIN L ; WILSON, NANCY ; O'CONNOR, DAVID H ; WATKINS, DAVID I . Reversion of CTL escape-variant immunodeficiency viruses in vivo. Nature Medicine (Print) , v. 10, p. 275-281, 2004.

• FRIEDRICH, T. C. ; FRYE, C. A. ; YANT, L. J. ; O'CONNOR, D. H. ; KRIEWALDT, N. A. ; BENSON, M. ; VOJNOV, L. ; DODDS, E. J. ; CULLEN, C. ; RUDERSDORF, R. ; HUGHES, A. L. ; WILSON, N. ; WATKINS, D. I. . Extraepitopic Compensatory Substitutions Partially Restore Fitness to Simian Immunodeficiency Virus Variants That Escape from an Immunodominant Cytotoxic-T-Lymphocyte Response. Journal of Virology (Print) , v. 78, p. 2581-2585, 2004.

• VOGEL, T. U. ; REYNOLDS, M. R. ; FULLER, D. H. ; VIELHUBER, K. ; SHIPLEY, T. ; FULLER, J. T. ; KUNSTMAN, K. J. ; SUTTER, G. ; MARTHAS, M. L. ; ERFLE, V. ; WOLINSKY, S. M. ; WANG, C. ; ALLISON, D. B. ; RUD, E. W. ; WILSON, N. ; MONTEFIORI, D. ; ALTMAN, J. D. ; WATKINS, D. I. . Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239. Journal of Virology (Print) , v. 77, p. 13348-13360, 2003.

• O'CONNOR, D. H. ; MOTHE, B. R. ; WEINFURTER, J. T. ; FUENGER, S. ; REHRAUER, W. M. ; JING, P. ; RUDERSDORF, R. R. ; LIEBL, M. E. ; KREBS, K. ; VASQUEZ, J. ; DODDS, E. ; LOFFREDO, J. ; MARTIN, S. ; MCDERMOTT, A. B. ; ALLEN, T. M. ; WANG, C. ; DOXIADIS, G. G. ; MONTEFIORI, D. C. ; HUGHES, A. ; BURTON, D. R. ; ALLISON, D. B. ; WOLINSKY, S. M. ; BONTROP, R. ; PICKER, L. J. ; WATKINS, D. I. . Major Histocompatibility Complex Class I Alleles Associated with Slow Simian Immunodeficiency Virus Disease Progression Bind Epitopes Recognized by Dominant Acute-Phase Cytotoxic-T-Lymphocyte Responses. Journal of Virology (Print) , v. 77, p. 9029-9040, 2003.

• NACSA, JANOS ; STANTON, JENNIFER ; KUNSTMAN, KEVIN J. ; TSAI, WEN-PO ; WATKINS, DAVID I. ; WOLINSKY, STEVEN M. ; FRANCHINI, GENOVEFFA . Emergence of Cytotoxic T Lymphocyte Escape Mutants following Antiretroviral Treatment Suspension in Rhesus Macaques Infected with SIVmac251. Virology (New York, N.Y. Print) , v. 305, p. 210-218, 2003.

• VOSS, G. ; MANSON, K. ; MONTEFIORI, D. ; WATKINS, D. I. ; HEENEY, J. ; WYAND, M. ; COHEN, J. ; BRUCK, C. . Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine. Journal of Virology (Print) , v. 77, p. 1049-1058, 2003.

• O'CONNOR, DAVID H. ; ALLEN, TODD M. ; WATKINS, DAVID I. . Cytotoxic T-Lymphocyte Escape Monitoring in Simian Immunodeficiency Virus Vaccine Challenge Studies. DNA and Cell Biology , v. 21, p. 659-664, 2002.

• VOGEL, T. U. ; FRIEDRICH, T. C. ; O'CONNOR, D. H. ; REHRAUER, W. ; DODDS, E. J. ; HICKMAN, H. ; HILDEBRAND, W. ; SIDNEY, J. ; SETTE, A. ; HUGHES, A. ; HORTON, H. ; VIELHUBER, K. ; RUDERSDORF, R. ; DE SOUZA, I. P. ; REYNOLDS, M. R. ; ALLEN, T. M. ; WILSON, N. ; WATKINS, D. I. . Escape in One of Two Cytotoxic T-Lymphocyte Epitopes Bound by a High-Frequency Major Histocompatibility Complex Class I Molecule, Mamu-A*02: a Paradigm for Virus Evolution and Persistence?. Journal of Virology (Print) , v. 76, p. 11623-11636, 2002.

• ALLEN, T. M. ; JING, P. ; CALORE, B. ; HORTON, H. ; O'CONNOR, D. H. ; HANKE, T. ; PIEKARCZYK, M. ; RUDDERSDORF, R. ; MOTHE, B. R. ; EMERSON, C. ; WILSON, N. ; LIFSON, J. D. ; BELYAKOV, I. M. ; BERZOFSKY, J. A. ; WANG, C. ; ALLISON, D. B. ; MONTEFIORI, D. C. ; DESROSIERS, R. C. ; WOLINSKY, S. ; KUNSTMAN, K. J. ; ALTMAN, J. D. ; SETTE, A. ; MCMICHAEL, A. J. ; WATKINS, D. I. . Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection. Journal of Virology (Print) , v. 76, p. 10507-10511, 2002.

• MOTHE, B. R. ; SIDNEY, J. ; DZURIS, J. L. ; LIEBL, M. E. ; FUENGER, S. ; WATKINS, D. I. ; SETTE, A. . Characterization of the Peptide-Binding Specificity of Mamu-B*17 and Identification of Mamu-B*17-Restricted Epitopes Derived from Simian Immunodeficiency Virus Proteins. The Journal of Immunology (1950) , v. 169, p. 210-219, 2002.

• EARL, PATRICIA L. ; WYATT, LINDA S. ; MONTEFIORI, DAVID C. ; BILSKA, MIROSLAWA ; WOODWARD, RUTH ; MARKHAM, PHILLIP D. ; MALLEY, JAMES D. ; VOGEL, THORSTEN U. ; ALLEN, TODD M. ; WATKINS, DAVID I. ; MILLER, NANCY ; MOSS, BERNARD . Comparison of Vaccine Strategies Using Recombinant env-gag-pol MVA with or without an Oligomeric Env Protein Boost in the SHIV Rhesus Macaque Model. Virology (New York, N.Y. Print) , v. 294, p. 270-281, 2002.

• O'CONNOR, DAVID H. ; ALLEN, TODD M. ; VOGEL, THORSTEN U. ; JING, PEICHENG ; DESOUZA, IVNA P. ; DODDS, ELIZABETH ; DUNPHY, EDWARD J. ; MELSAETHER, CHERI ; MOTHÉ, BIANCA ; YAMAMOTO, HIROSHI ; HORTON, HELEN ; WILSON, NANCY ; HUGHES, AUSTIN L. ; WATKINS, DAVID I. . Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nature Medicine (Print) , v. 8, p. 493-499, 2002.

• HORTON, HELEN ; VOGEL, THORSTEN ; O CONNOR, DAVID ; PICKER, LOUIS ; WATKINS, DAVID I . Analysis of the immune response and viral evolution during the acute phase of SIV infection. Vaccine (Guildford) , v. 20, p. 1927-1932, 2002.

• ALLEN, T. M. ; MORTARA, L. ; MOTHE, B. R. ; LIEBL, M. ; JING, P. ; CALORE, B. ; PIEKARCZYK, M. ; RUDDERSDORF, R. ; O'CONNOR, D. H. ; WANG, X. ; WANG, C. ; ALLISON, D. B. ; ALTMAN, J. D. ; SETTE, A. ; DESROSIERS, R. C. ; SUTTER, G. ; WATKINS, D. I. . Tat-Vaccinated Macaques Do Not Control Simian Immunodeficiency Virus SIVmac239 Replication. Journal of Virology (Print) , v. 76, p. 4108-4112, 2002.

• MOTHE, B. R. ; HORTON, H. ; CARTER, D. K. ; ALLEN, T. M. ; LIEBL, M. E. ; SKINNER, P. ; VOGEL, T. U. ; FUENGER, S. ; VIELHUBER, K. ; REHRAUER, W. ; WILSON, N. ; FRANCHINI, G. ; ALTMAN, J. D. ; HAASE, A. ; PICKER, L. J. ; ALLISON, D. B. ; WATKINS, D. I. . Dominance of CD8 Responses Specific for Epitopes Bound by a Single Major Histocompatibility Complex Class I Molecule during the Acute Phase of Viral Infection. Journal of Virology (Print) , v. 76, p. 875-884, 2002.

• ALLEN, T. M. ; MOTHE, B. R. ; SIDNEY, J. ; JING, P. ; DZURIS, J. L. ; LIEBL, M. E. ; VOGEL, T. U. ; O'CONNOR, D. H. ; WANG, X. ; WUSSOW, M. C. ; THOMSON, J. A. ; ALTMAN, J. D. ; WATKINS, D. I. ; SETTE, A. . CD8+ Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing. Journal of Virology (Print) , v. 75, p. 738-749, 2001.

• VOGEL, T. U. ; ALLEN, T. M. ; ALTMAN, J. D. ; WATKINS, D. I. . Functional Impairment of Simian Immunodeficiency Virus-Specific CD8+ T Cells during the Chronic Phase of Infection. Journal of Virology (Print) , v. 75, p. 2458-2461, 2001.

• HEL, Z. ; TSAI, W.-P. ; THORNTON, A. ; NACSA, J. ; GIULIANI, L. ; TRYNISZEWSKA, E. ; POUDYAL, M. ; VENZON, D. ; WANG, X. ; ALTMAN, J. ; WATKINS, D. I. ; LU, W. ; VON GEGERFELT, A. ; FELBER, B. K. ; TARTAGLIA, J. ; PAVLAKIS, G. N. ; FRANCHINI, G. . Potentiation of Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cell Responses by a DNA-SIV and NYVAC-SIV Prime/Boost Regimen. The Journal of Immunology (1950) , v. 167, p. 7180-7191, 2001.

• BELYAKOV, IGOR M. ; HEL, ZDENEK ; KELSALL, BRIAN ; KUZNETSOV, VLADIMIR A. ; AHLERS, JEFFREY D. ; NACSA, JANOS ; WATKINS, DAVID I. ; ALLEN, TODD M. ; SETTE, ALESSANDRO ; ALTMAN, JOHN ; WOODWARD, RUTH ; MARKHAM, PHILLIP D. ; CLEMENTS, JOHN D. ; FRANCHINI, GENOVEFFA ; STROBER, WARREN ; BERZOFSKY, JAY A. . Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques. Nature Medicine (Print) , v. 7, p. 1320-1326, 2001.

• SCHRAMM, R.DEE ; PAPROCKI, ANN MARIE ; WATKINS, DAVID I. . Birth of MHC-defined rhesus monkeys produced by assisted reproductive technology. Vaccine (Guildford) , v. 20, p. 603-607, 2001.

• DZURIS, J. L. ; SIDNEY, J. ; HORTON, H. ; CORREA, R. ; CARTER, D. ; CHESNUT, R. W. ; WATKINS, D. I. ; SETTE, A. . Molecular Determinants of Peptide Binding to Two Common Rhesus Macaque Major Histocompatibility Complex Class II Molecules. Journal of Virology (Print) , v. 75, p. 10958-10968, 2001.

• O'CONNOR, DAVID ; ALLEN, TODD ; WATKINS, DAVID I. . Vaccination with CTL epitopes that escape: an alternative approach to HIV vaccine development?. Immunology Letters , v. 79, p. 77-84, 2001.

• HORTON, HELEN ; REHRAUER, WILLIAM ; MEEK, ELIABETH C. ; SHULTZ, MILLICENT A. ; PIEKARCZYK, MARIAN S. ; JING, PEICHENG ; CARTER, DONALD K. ; STEFFEN, SUSAN R. ; CALORE, BRIANA ; URVATER, JULIE A. ; VOGEL, THORSTEN U. ; WILSON, NANCY A. ; WATKINS, DAVID I. . A common rhesus macaque MHC class I molecule which binds a cytotoxic T-lymphocyte epitope in Nef of simian immunodeficiency virus. Immunogenetics (New York) , v. 53, p. 423-426, 2001.

• HUGHES, A. L. ; WESTOVER, K. ; DA SILVA, J. ; O'CONNOR, D. H. ; WATKINS, D. I. . Simultaneous Positive and Purifying Selection on Overlapping Reading Frames of the tat and vpr Genes of Simian Immunodeficiency Virus. Journal of Virology (Print) , v. 75, p. 7966-7972, 2001.

• SLUKVIN, I.I. ; WATKINS, D.I. ; GOLOS, T.G. . Phenotypic and functional characterization of rhesus monkey decidual lymphocytes: rhesus decidual large granular lymphocytes express CD56 and have cytolytic activity. Journal of Reproductive Immunology , v. 50, p. 57-79, 2001.

• URVATER, J. A. ; HICKMAN, H. ; DZURIS, J. L. ; PRILLIMAN, K. ; ALLEN, T. M. ; SCHWARTZ, K. J. ; LORENTZEN, D. ; SHUFFLEBOTHAM, C. ; COLLINS, E. J. ; NEIFFER, D. L. ; RAPHAEL, B. ; HILDEBRAND, W. ; SETTE, A. ; WATKINS, D. I. . Gorillas with Spondyloarthropathies Express an MHC Class I Molecule with Only Limited Sequence Similarity to HLA-B27 that Binds Peptides with Arginine at P2. The Journal of Immunology (1950) , v. 166, p. 3334-3344, 2001.

• DZURIS, J. L. ; SIDNEY, J. ; APPELLA, E. ; CHESNUT, R. W. ; WATKINS, D. I. ; SETTE, A. . Conserved MHC Class I Peptide Binding Motif Between Humans and Rhesus Macaques. The Journal of Immunology (1950) , v. 164, p. 283-291, 2000.

• DZURIS, J. L. ; SIDNEY, J. ; APPELLA, E. ; CHESNUT, R. W. ; WATKINS, D. I. ; SETTE, A. . Conserved MHC Class I Peptide Binding Motif Between Humans and Rhesus Macaques. The Journal of Immunology (1950) , v. 164, p. 283-291, 2000.

• URVATER, J. A. ; OTTING, N. ; LOEHRKE, J. H. ; RUDERSDORF, R. ; SLUKVIN, I. I. ; PIEKARCZYK, M. S. ; GOLOS, T. G. ; HUGHES, A. L. ; BONTROP, R. E. ; WATKINS, D. I. . Mamu-I: A Novel Primate MHC Class I B-Related Locus with Unusually Low Variability. The Journal of Immunology (1950) , v. 164, p. 1386-1398, 2000.

• URVATER, J.A. ; STEFFEN, S.R. ; REHRAUER,, W. ; WATKINS, D.I. . An unusual insertion in intron 2 of apparently functional MHC class I alleles in rhesus macaques. Tissue Antigens , v. 55, p. 153-156, 2000.

• ALLEN, T. M. ; VOGEL, T. U. ; FULLER, D. H. ; MOTHE, B. R. ; STEFFEN, S. ; BOYSON, J. E. ; SHIPLEY, T. ; FULLER, J. ; HANKE, T. ; SETTE, A. ; ALTMAN, J. D. ; MOSS, B. ; MCMICHAEL, A. J. ; WATKINS, D. I. . Induction of AIDS Virus-Specific CTL Activity in Fresh, Unstimulated Peripheral Blood Lymphocytes from Rhesus Macaques Vaccinated with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen. The Journal of Immunology (1950) , v. 164, p. 4968-4978, 2000.

• URVATER, J. A. ; MCADAM, S. N. ; LOEHRKE, J. H. ; ALLEN, T. M. ; MORAN, J. L. ; ROWELL, T. J. ; ROJO, S. ; LóPEZ DE CASTRO, J.A. ; TAUROG, J. D. ; WATKINS, D. I. . A high incidence of Shigella -induced arthritis in a primate species: major histocompatibility complex class I molecules associated with resistance and susceptiblity, and their relationship to HLA-B27. Immunogenetics (New York) , v. 51, p. 314-325, 2000.

• CHEN, Z. W. ; CRAIU, A. ; SHEN, L. ; KURODA, M. J. ; IROKU, U. C. ; WATKINS, D. I. ; VOSS, G. ; LETVIN, N. L. . Simian Immunodeficiency Virus Evades a Dominant Epitope-Specific Cytotoxic T Lymphocyte Response Through a Mutation Resulting in the Accelerated Dissociation of Viral Peptide and MHC Class I. The Journal of Immunology (1950) , v. 164, p. 6474-6479, 2000.

• DE GROOT, NATASJA G. ; OTTING, N. ; ARGüELLO, RAFAEL ; WATKINS, DAVID I. ; DOXIADIS, GABY G. M. ; MADRIGAL, J. ALEJANDRO ; BONTROP, R. E. . Major histocompatibility complex class I diversity in a West African chimpanzee population: implications for HIV research. Immunogenetics (New York) , v. 51, p. 398-409, 2000.

• EVANS, D. T. ; JING, P. ; ALLEN, T. M. ; O'CONNOR, D. H. ; HORTON, H. ; VENHAM, J. E. ; PIEKARCZYK, M. ; DZURIS, J. ; DYKHUZEN, M. ; MITCHEN, J. ; RUDERSDORF, R. A. ; PAUZA, C. D. ; SETTE, A. ; BONTROP, R. E. ; DEMARS, R. ; WATKINS, D. I. . Definition of Five New Simian Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitopes and Their Restricting Major Histocompatibility Complex Class I Molecules: Evidence for an Influence on Disease Progression. Journal of Virology (Print) , v. 74, p. 7400-7410, 2000.

• SLUKVIN, I. I. ; LUNN, D. P. ; WATKINS, D. I. ; GOLOS, T. G. . Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey. Proceedings of the National Academy of Sciences of the United States of America , v. 97, p. 9104-9109, 2000.

• CROMWELL, M. A. ; VEAZEY, R. S. ; ALTMAN, J. D. ; MANSFIELD, K. G. ; GLICKMAN, R. ; ALLEN, T. M. ; WATKINS, D. I. ; LACKNER, A. A. ; JOHNSON, R. P. . Induction of Mucosal Homing Virus-Specific CD8+ T Lymphocytes by Attenuated Simian Immunodeficiency Virus. Journal of Virology (Print) , v. 74, p. 8762-8766, 2000.

• WATKINS, DAVID I. ; ALLEN, TODD M. ; O'CONNOR, DAVID H. ; JING, PEICHENG ; DZURIS, JOHN L. ; MOTHÉ, BIANCA R. ; VOGEL, THORSTEN U. ; DUNPHY, ED ; LIEBL, MAX E. ; EMERSON, CAROL ; WILSON, NANCY ; KUNSTMAN, KEVIN J. ; WANG, XIAOCHI ; ALLISON, DAVID B. ; HUGHES, AUSTIN L. ; DESROSIERS, RONALD C. ; ALTMAN, JOHN D. ; WOLINSKY, STEVEN M. ; SETTE, ALESSANDRO . Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature (London) , v. 407, p. 386-390, 2000.

• SIDNEY, J. ; DZURIS, J. L. ; NEWMAN, M. J. ; JOHNSON, R. P. ; AMITINDER, K. ; WALKER, C. M. ; APPELLA, E. ; MOTHE, B. ; WATKINS, D. I. ; SETTE, A. . Definition of the Mamu A*01 Peptide Binding Specificity: Application to the Identification of Wild-Type and Optimized Ligands from Simian Immunodeficiency Virus Regulatory Proteins. The Journal of Immunology (1950) , v. 165, p. 6387-6399, 2000.

• BOYSON, JONATHAN E. ; IWANAGA, KRISTEN K. ; URVATER, JULIE A. ; HUGHES, AUSTIN L. ; GOLOS, THADDEUS G. ; WATKINS, D. I. . Evolution of a new nonclassical MHC class I locus in two Old World primate species. Immunogenetics (New York) , v. 49, p. 86-98, 1999.

• CADAVID, L. F. ; MEJíA, BEATRIZ E. ; WATKINS, D. I. . MHC class I genes in a New World primate, the cotton-top tamarin ( Saguinus oedipus ), have evolved by an active process of loci turnover. Immunogenetics (New York) , v. 49, p. 196-205, 1999.

• WATKINS, DAVID I . THREE DIFFERENT MHC CLASS I MOLECULES BIND THE SAME CTL EPITOPE OF THE INFLUENZA VIRUS IN A PRIMATE SPECIES WITH LIMITED MHC CLASS I DIVERSITY. The Journal of Immunology (1950) , v. 162, p. 3970, 1999.

• SLUKVIN, I.I. ; WATKINS, D.I. ; GOLOS, T.G. . Tissue distribution of the mRNA for a rhesus monkey major histocompatibility class Ib molecule, Mamu-AG. Tissue Antigens , v. 53, p. 282-291, 1999.

• VOGEL, THORSTEN U. ; EVANS, DAVID T. ; URVATER, JULIE A. ; O'CONNORI, DAVID H. ; HUGHES, AUSLIN L. ; WATKINS, DAVID I. . Major histocompatibility complex class I genes in primates: co-evolution with pathogens. Immunological Reviews , v. 167, p. 327-337, 1999.

• SLUKVIN, I.I ; BOYSON, J.E ; WATKINS, D.I ; GOLOS, T.G . A nonhuman primate model for maternal-fetal immune tolerance. Transplantation Proceedings , v. 31, p. 1844-1846, 1999.

• DAVID. I. WATKINS . EFFECTIVE INDUCTION OF SIMIAN IMMUNODEFICIENCY VIRUS-SPECIFIC CYTOTOXIC T LYMPHOCYTES IN MACAQUES BY USING A MULTIEPITOPE GENE AND DNA PRIME-MODIFIED VACCINIA VIRUS ANKARA BOOST VACCINATION REGIMEN. Journal of Virology (Print) , v. 73, p. 7524, 1999.

• DAVID. I. WATKINS . THE SIMIAN IMMUNODEFICIENCY VIRUS ENVELOPE GLYCOPROTEIN CONTAINS TWO EPITOPES PRESENTED BY THE MAMU-A*01 CLASS I MOLECULE. Journal of Virology (Print) , v. 73, p. 8035, 1999.

• EVANS, DAVID T. ; O'CONNOR, DAVID H. ; JING, PEICHENG ; DZURIS, JOHN L. ; SIDNEY, JOHN ; DA SILVA, JACK ; ALLEN, TODD M. ; HORTON, HELEN ; VENHAM, JOHN E. ; RUDERSDORF, RICHARD A. ; VOGEL, THORSTEN ; PAUZA, C. DAVID ; BONTROP, RONALD E. ; DEMARS, ROBERT ; SETTE, ALESSANDRO ; HUGHES, AUSTIN L. ; WATKINS, DAVID I. . Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nature Medicine (Print) , v. 5, p. 1270-1276, 1999.

• O'CONNOR, D. H. ; WATKINS, D. I. . Houdini's box: towards an understanding of AIDS virus escape from the cytotoxic T-lymphocyte response. Immunogenetics (New York) , v. 50, p. 237-241, 1999.

• EVANS, DAVID T. ; PIEKARCZYK, MARIAN S. ; CADAVID, LUIS ; HINSHAW, VIRGINIA S. ; WATKINS, D. I. . Two different primate species express an identical functional MHC class I allele. Immunogenetics (New York) , v. 47, p. 206-211, 1998.

• WATKINS, DAVID I . THE MHC-E LOCUS IS THE MOST WELL CONSERVED OF ALL KNOWN PRIMATE CLASS I HISTOCOMPATIBILITY GENES. The Journal of Immunology (1950) , v. 160, p. 189, 1998.

• KURODA, M. J. ; SCHMITZ, J. E. ; BAROUCH, D. H. ; CRAIU, A. ; ALLEN, T. M. ; SETTE, A. ; WATKINS, D. I. ; FORMAN, M. A. ; LETVIN, N. L. . Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus-infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I-Peptide Complex. The Journal of Experimental Medicine , v. 187, p. 1373-1381, 1998.

• WATKINS, DAVID I . CHARACTERIZATION OF THE PEPTIDE BINDING MOTIF OF A RHESUS MHC CLASS I MOLECULE (MAMU-A*01) THAT BINDS AN IMMUNODOMINANT CTL EPITOPE FROM SIMIAN IMMUNO DEFICIENCY VIRUS. The Journal of Immunology (1950) , v. 160, p. 6062, 1998.

• ALDRIDGE, B. M. ; MCGUIRK, S. M. ; CLARK, R. J. ; KNAPP, L. A. ; WATKINS, D. I. ; LUNN, D. P. . Denaturing gradient gel electrophoresis: a rapid method for differentiating BoLA-DRB3 alleles. Animal Genetics (Print) , v. 29, p. 389-394, 1998.

• KNAPP, L. A. ; CADAVID, LUIS F. ; EBERLE, MARY E. ; KNECHTLE, STUART J. ; BONTROP, RONALD E. ; WATKINS, DAVID I. . Identification of new Mamu-DRB alleles using DGGE and direct sequencing. Immunogenetics (New York) , v. 45, p. 171-179, 1997.

• EBERLE, M. ; LORENTZEN, D. F. ; IWANAGA, K. K. ; HENNES, L. F. ; WATKINS, D. I. . Identification of a new HLA-B*08 variant, HLA-B*0804. Tissue Antigens , v. 49, p. 256-261, 1997.

• EBERLE, M. ; KNAPP, L. A. ; IWANAGA, K. K. ; DOMANICO, M. J. ; AIYER, K. ; WATKINS, D. I. . typing by allele separation followed by direct sequencing. Tissue Antigens , v. 49, p. 365-375, 1997.

• FECHNER, JOHN H. ; VARGO, DANIEL J. ; GEISSLER, EDWARD K. ; GRAEB, CHRISTIAN ; WANG, JUE ; HANAWAY, MICHAEL J. ; WATKINS, DAVID I. ; PIEKARCZYK, MARIAN ; NEVILLE, DAVID M. ; KNECHTLE, STUART J. . SPLIT TOLERANCE INDUCED BY IMMUNOTOXIN IN A RHESUS KIDNEY ALLOGRAFT MODEL1. Transplantation , v. 63, p. 1339-1345, 1997.

• WATKINS, DAVID I . IMMUNODOMINANCE OF A SINGLE CTL EPITOPE IN A PRIMATE SPECIES WITH LIMITED MHC CLASS I POLYMORPHISM. The Journal of Immunology (1950) , v. 159, p. 1997, 1997.

• KNAPP, L. A. ; LEHMANN, E. ; HENNES, L. ; EBERLE, M. E. ; WATKINS, D. I. . High-resolution typing using denaturing gradient gel electrophoresis and direct sequencing. Tissue Antigens , v. 50, p. 170-177, 1997.

• CADAVID, L. F. ; WATKINS, D. I. . THE DUPLICATIVE NATURE OF THE MHC CLASS I GENES: AN EVOLUTIONARY PERSPECTIVE. European Journal of Immunogenetics (Print) , v. 24, p. 313-322, 1997.

• WATKINS, DAVID I . IDENTIFICATION OF A NOVEL MHC CLASS I GENE, MAMU-AG, EXPRESSED IN THE PLACENTA OF A PRIMATE WITH AN INACTIVATED G LOCUS. The Journal of Immunology (1950) , v. 159, p. 1997, 1997.

• CADAVID, L. F. ; WATKINS, D. I. . Heirs of the jaguar and the anaconda: HLA, conquest and disease in the indigenous populations of the Americas. Tissue Antigens , v. 50, p. 209-218, 1997.

• IWANAGA, K. K. ; EBERLE, M. ; KOLMAN, C. J. ; BERMINGHAM, E. ; WATKINS, D. I. . Further diversification of the locus in Central American Amerindians: new and alleles in the Kuna of Panama. Tissue Antigens , v. 50, p. 251-257, 1997.

• CADAVID, L. F. ; SHUFFLEBOTHAM, C. ; RUIZ, F. J. ; YEAGER, M. ; HUGHES, A. L. ; WATKINS, D. I. . Evolutionary instability of the major histocompatibility complex class I loci in New World primates. Proceedings of the National Academy of Sciences of the United States of America , v. 94, p. 14536-14541, 1997.

• KNAPP, L.A. ; LEHMANN, E. ; PIEKARCZYK, M.S. ; URVATER, J.A. ; WATKINS, D.I. . A high frequency of in the rhesus macaque detected by polymerase chain reaction with sequence-specific primers and direct sequencing. Tissue Antigens , v. 50, p. 657-661, 1997.

• LORENTZEN, D. F. ; IWANAGA, K. K. ; MEUER, K. J. ; MORITZ, T. L. ; WATKINS, D. I. . A 25% error rate in serologic typing of HLA-B homozygotes. Tissue Antigens , v. 50, p. 359-365, 1997.

• LOFLIN, PAUL T. ; LAUD, PURNIMA R. ; WATKINS, DAVID I. ; LAWLOR, DAVID A. . Identification of new TAP2 alleles in gorilla: evolution of the locus within hominoids. Immunogenetics (New York) , v. 44, p. 161-169, 1996.

• ALLEN, T. M. ; LANCHBURY, JERRY S. ; HUGHES, AUSTIN L. ; WATKINS, DAVID I. . The T-cell receptor β chain-encoding gene repertoire of a New World primate species, the cotton-top tamarin. Immunogenetics (New York) , v. 45, p. 151-160, 1996.

• GARBER, T. L. ; MCADAM, S. N. ; BUTLER, L. M. ; CROCKER, P. ; PIEKARCZYK, M. ; TROUP, G. M. ; MILFORD, E. L. ; WATKINS, D. I. . HLA-B alleles of the Navajo: no evidence for rapid evolution in the Nadene. Tissue Antigens , v. 47, p. 143-146, 1996.

• WATKINS, DAVID I . MHC CLASS I-PROCESSED PSEUDOGENES IN NEW WORLD PRIMATES PROVIDE EVIDENCE FOR RAPID TURNOVER IN MHC CLASS I GENES. The Journal of Immunology (1950) , v. 157, p. 2403, 1996.

• WATKINS, DAVID I . IDENTIFICATION OF THE RHESUS MONKEY HLA-G ORTHOLOG : MANU-G IS A PSEUDOGENE. The Journal of Immunology (1950) , v. 157, p. 5428, 1996.

• GARBER, THEODORE L. ; BUTLER, LESLEY M. ; TRACHTENBERG, ELIZABETH A. ; ERLICH, HENRY A. ; RICKARDS, OLGA ; DE STEFANO, GIANFRANCO ; WATKINS, DAVID I. . HLA-B alleles of the Cayapa of Ecuador: new B39 and B15 alleles. Immunogenetics (New York) , v. 42, p. 19-27, 1995.

• BOYSON, JONATHANE. ; MCADAM, STEPHENN. ; GALLIMORE, AWEN ; GOLOS, THADDEUSG. ; LIU, XIAOMIN ; GOTCH, FRANCESM. ; HUGHES, AUSTINL. ; WATKINS, DAVIDI. . The MHC E locus in macaques is polymorphic and is conserved between macaques and humans. Immunogenetics (New York) , v. 41, p. 59, 1995.

• WATKINS, DAVID I. . The Evolution of Major Histocompatibility Class I Genes in Primates. Critical Reviews in Immunology , v. 15, p. 1-29, 1995.

• GYLLENSTEN, ULF ; BERGSTR'M, TOMAS ; JOSEFSSON, AGNETHA ; SUNDVALL, MATS ; SAVAGE, ANNE ; BLUMER, EVAN S. ; HUMBERTO GIRALDO, L. ; SOTO, LUIS H. ; WATKINS, DAVID I. . The cotton-top tamarin revisited: Mhc class I polymorphism of wild tamarins, and polymorphism and allelic diversity of the class II DQA1, DQB1, and DRB loci. Immunogenetics (New York) , v. 40, p. 167-176, 1994.

• GARBER, THEODOREL. ; HUGHES, AUSTINL. ; WATKINS, DAVIDI. ; TEMPLETON, JOEW. . Evidence for at least three transcribed BoLA class I loci. Immunogenetics (New York) , v. 39, p. 257, 1994.

• MCADAM, S. N. ; BOYSON, J. E. ; LIU, X. ; GARBER, T. L. ; HUGHES, A. L. ; BONTROP, R. E. ; WATKINS, D. I. . A uniquely high level of recombination at the HLA-B locus.. Proceedings of the National Academy of Sciences of the United States of America , v. 91, p. 5893-5897, 1994.

Projetos de pesquisa

• 2014 - Atual

  Can vaccine-induced CD8 T cells prevent chronica phase AIDS virus replication?, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: David Ian Watkins - Coordenador.

• 2013 - 2014

  Innovative persistent viral vector-based vaccine against DENV, Situação: Concluído; Natureza: Pesquisa. , Integrantes: David Ian Watkins - Coordenador.

• 2012 - Atual

  Yellow Fever, rDNA (EP+IL-12) and rAd35 as Vectors for AIDS Vaccine Development, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: David Ian Watkins - Coordenador.

• 2011 - 2013

  SIV-specific Mamu-E-restricted CD8+ T cells, Situação: Concluído; Natureza: Pesquisa. , Integrantes: David Ian Watkins - Coordenador.

• 2007 - 2012

  Minigene vaccination with early presented viral proteins, Situação: Concluído; Natureza: Pesquisa. , Integrantes: David Ian Watkins - Coordenador.

• 2002 - Atual

  The functional significance of CTL escape, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: David Ian Watkins - Coordenador.

• 2001 - 2013

  A novel, logical approach to HIV vaccine development, Situação: Concluído; Natureza: Pesquisa. , Integrantes: David Ian Watkins - Coordenador.

• 2001 - Atual

  MHC typing of macaques used in AIDS research, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: David Ian Watkins - Coordenador.

• 2000 - Atual

  MHC-bound, SIV-derived, CTL and HTL epitopes, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: David Ian Watkins - Coordenador.