Bradley Olsen

Pós-doutorado

Formação complementar

Idiomas

Áreas de atuação

Orientou

Produções bibliográficas

• LAM, CHRISTOPHER N. ; CHANG, DONGSOOK ; WANG, MUZHOU ; CHEN, WEI-REN ; OLSEN, BRADLEY D. . The shape of protein-polymer conjugates in dilute solution. Journal of Polymer Science. Part A, Polymer Chemistry , v. 54, p. 292-302, 2016.

• GLASSMAN, MATTHEW J. ; AVERY, REGINALD K. ; KHADEMHOSSEINI, ALI ; OLSEN, BRADLEY D. . Toughening of Thermoresponsive Arrested Networks of Elastin-Like Polypeptides To Engineer Cytocompatible Tissue Scaffolds. Biomacromolecules , v. 17, p. 415-426, 2016.

• GKIKAS, MANOS ; AVERY, REGINALD K. ; OLSEN, BRADLEY D. . Thermoresponsive and Mechanical Properties of Poly( -proline) Gels. Biomacromolecules , v. 17, p. 399-406, 2016.

• WANG, RUI ; ALEXANDER-KATZ, ALFREDO ; JOHNSON, JEREMIAH A. ; OLSEN, BRADLEY D. . Universal Cyclic Topology in Polymer Networks. Physical Review Letters (Print) , v. 116, p. 188302, 2016.

• QIN, GUOKUI ; PEREZ, PAOLA M. ; MILLS, CAROLYN E. ; OLSEN, BRADLEY D. . Effect of ELP Sequence and Fusion Protein Design on Concentrated Solution Self-Assembly. Biomacromolecules , v. 17, p. 928-934, 2016.

• TANG, SHENGCHANG ; PURYEAR, WENDY B. ; SEIFRIED, BRIAN M. ; DONG, XUEHUI ; RUNSTADLER, JONATHAN A. ; RIBBECK, KATHARINA ; OLSEN, BRADLEY D. . Antiviral Agents from Multivalent Presentation of Sialyl Oligosaccharides on Brush Polymers. ACS Macro Letters , v. 5, p. 413-418, 2016.

• LI, ZHENG-JUN ; QIAO, KANGJIAN ; SHI, WEICHAO ; PEREIRA, BRIAN ; ZHANG, HAORAN ; OLSEN, BRADLEY D. ; STEPHANOPOULOS, GREGORY . Biosynthesis of poly(glycolate-co-lactate-co-3-hydroxybutyrate) from glucose by metabolically engineered Escherichia coli. METABOLIC ENGINEERING , v. 35, p. 1-8, 2016.

• CHANG, DONGSOOK ; OLSEN, BRADLEY D. . Self-assembly of protein-zwitterionic polymer bioconjugates into nanostructured materials. Polymer Chemistry , v. 7, p. 2410-2418, 2016.

• HUANG, AARON ; OLSEN, BRADLEY D. . Self-Assembly of Differently Shaped Protein-Polymer Conjugates through Modification of the Bioconjugation Site. MACROMOLECULAR RAPID COMMUNICATIONS , v. 37, p. 1268-1274, 2016.

• LAM, CHRISTOPHER N. ; YAO, HELEN ; OLSEN, BRADLEY D. . The Effect of Protein Electrostatic Interactions on Globular Protein-Polymer Block Copolymer Self-Assembly. Biomacromolecules , v. 17, p. 2820-2829, 2016.

• TANG, SHENGCHANG ; HABICHT, AXEL ; LI, SHUAILI ; SEIFFERT, SEBASTIAN ; OLSEN, BRADLEY D. . Self-Diffusion of Associating Star-Shaped Polymers. MACROMOLECULES , v. 49, p. 5599-5608, 2016.

• AVERY, R. K. ; ALBADAWI, H. ; AKBARI, M. ; ZHANG, Y. S. ; DUGGAN, M. J. ; SAHANI, D. V. ; OLSEN, B. D. ; KHADEMHOSSEINI, A. ; OKLU, R. . An injectable shear-thinning biomaterial for endovascular embolization. Science Translational Medicine , v. 8, p. 365ra156-365ra156, 2016.

• ZHONG, M. ; WANG, R. ; KAWAMOTO, K. ; OLSEN, B. D. ; JOHNSON, J. A. . Quantifying the impact of molecular defects on polymer network elasticity. Science (New York, N.Y.) , v. 353, p. 1264-1268, 2016.

• OBERMEYER, ALLIE C. ; MILLS, CAROLYN E. ; DONG, XUE-HUI ; FLORES, ROMEO J. ; OLSEN, BRADLEY D. . Complex coacervation of supercharged proteins with polyelectrolytes. Soft Matter (Print) , v. 12, p. 3570-3581, 2016.

• SING, MICHELLE K. ; WANG, ZHEN-GANG ; MCKINLEY, GARETH H. ; OLSEN, BRADLEY D. . Celebrating Soft Matter's 10th Anniversary: Chain configuration and rate-dependent mechanical properties in transient networks. Soft Matter (Print) , v. 11, p. 2085-2096, 2015.

• QIN, GUOKUI ; GLASSMAN, MATTHEW J. ; LAM, CHRISTOPHER N. ; CHANG, DONGSOOK ; SCHAIBLE, ERIC ; HEXEMER, ALEXANDER ; OLSEN, BRADLEY D. . Topological Effects on Globular Protein-ELP Fusion Block Copolymer Self-Assembly. Advanced Functional Materials (Print) , v. 25, p. 729-738, 2015.

• OBERMEYER, ALLIE C. ; OLSEN, BRADLEY D. . Synthesis and Application of Protein-Containing Block Copolymers. ACS Macro Letters , v. 4, p. 101-110, 2015.

• HUANG, AARON ; QIN, GUOKUI ; OLSEN, BRADLEY D. . Highly Active Biocatalytic Coatings from Protein-Polymer Diblock Copolymers. ACS Applied Materials & Interfaces (Print) , v. 7, p. 14660-14669, 2015.

• WANG, MUZHOU ; LIKHTMAN, ALEXEI E. ; OLSEN, BRADLEY D. . Tube Curvature Slows the Motion of Rod-Coil Block Copolymers through Activated Reptation. ACS Macro Letters , v. 4, p. 242-246, 2015.

• WANG, MUZHOU ; TIMACHOVA, KSENIA ; OLSEN, BRADLEY D. . Self-Diffusion and Constraint Release in Isotropic Entangled Rod-Coil Block Copolymers. MACROMOLECULES , v. 48, p. 3121-3129, 2015.

• GLASSMAN, MATTHEW J. ; OLSEN, BRADLEY D. . End Block Design Modulates the Assembly and Mechanics of Thermoresponsive, Dual-Associative Protein Hydrogels. MACROMOLECULES , v. 48, p. 1832-1842, 2015.

• KIM, MINKYU ; CHEN, WESLEY G. ; KANG, JEON WOONG ; GLASSMAN, MATTHEW J. ; RIBBECK, KATHARINA ; OLSEN, BRADLEY D. . Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport. ADVANCED MATERIALS , v. 27, p. 4207-4212, 2015.

• LI, XIN ; LAM, CHRISTOPHER N. ; SÁNCHEZ-DIÁZ, LUIS E. ; SMITH, GREGORY S. ; OLSEN, BRADLEY D. ; CHEN, WEI-REN . Scattering from Colloid-Polymer Conjugates with Excluded Volume Effect. ACS Macro Letters , v. 4, p. 165-170, 2015.

• TANG, SHENGCHANG ; WANG, MUZHOU ; OLSEN, BRADLEY D. . Anomalous Self-Diffusion and Sticky Rouse Dynamics in Associative Protein Hydrogels. Journal of the American Chemical Society (Print) , v. 137, p. 3946-3957, 2015.

• WANG, MUZHOU ; LIKHTMAN, ALEXEI E. ; OLSEN, BRADLEY D. . Crossover between activated reptation and arm retraction mechanisms in entangled rod-coil block copolymers. The Journal of Chemical Physics , v. 143, p. 184904, 2015.

• ZHANG, YI-NAN ; AVERY, REGINALD K. ; VALLMAJO-MARTIN, QUERALT ; ASSMANN, ALEXANDER ; VEGH, ANDREA ; MEMIC, ADNAN ; OLSEN, BRADLEY D. ; ANNABI, NASIM ; KHADEMHOSSEINI, ALI . A Highly Elastic and Rapidly Crosslinkable Elastin-Like Polypeptide-Based Hydrogel for Biomedical Applications. Advanced Functional Materials (Print) , v. 25, p. 4814-4826, 2015.

• GLASSMAN, MATTHEW J. ; OLSEN, BRADLEY D. . Arrested Phase Separation of Elastin-like Polypeptide Solutions Yields Stiff, Thermoresponsive Gels. Biomacromolecules , v. 16, p. 3762-3773, 2015.

• KAWAMOTO, KEN ; ZHONG, MINGJIANG ; WANG, RUI ; OLSEN, BRADLEY D. ; JOHNSON, JEREMIAH A. . Loops versus Branch Functionality in Model Click Hydrogels. MACROMOLECULES , v. 48, p. 8980-8988, 2015.

• 2014 AVERY, REGINALD K. ; ASSMANN, ALEXANDER ; PAUL, ARGHYA ; MCKINLEY, GARETH H. ; KHADEMHOSSEINI, ALI ; OLSEN, BRADLEY D. . Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage. ACS Nano , v. 8, p. 9833-9842, 2014.

• CHANG, DONGSOOK ; LAM, CHRISTOPHER N. ; TANG, SHENGCHANG ; OLSEN, BRADLEY D. . Effect of polymer chemistry on globular protein-polymer block copolymer self-assembly. Polymer Chemistry , v. 5, p. 4884-4895, 2014.

• ZHOU, HUAXING ; SCHÖN, EVA-MARIA ; WANG, MUZHOU ; GLASSMAN, MATTHEW J. ; LIU, JENNY ; ZHONG, MINGJIANG ; DÍAZ DÍAZ, DAVID ; OLSEN, BRADLEY D. ; JOHNSON, JEREMIAH A. . Crossover Experiments Applied to Network Formation Reactions: Improved Strategies for Counting Elastically Inactive Molecular Defects in PEG Gels and Hyperbranched Polymers. Journal of the American Chemical Society (Print) , v. 136, p. 9464-9470, 2014.

• STEWART-SLOAN, CHARLOTTE R. ; OLSEN, BRADLEY D. . Protonation-Induced Microphase Separation in Thin Films of a Polyelectrolyte-Hydrophilic Diblock Copolymer. ACS Macro Letters , v. 3, p. 410-414, 2014.

• LAM, CHRISTOPHER N. ; KIM, MINKYU ; THOMAS, CARLA S. ; CHANG, DONGSOOK ; SANOJA, GABRIEL E. ; OKWARA, CHIMDIMMA U. ; OLSEN, BRADLEY D. . The Nature of Protein Interactions Governing Globular Protein-Polymer Block Copolymer Self-Assembly. Biomacromolecules , v. 15, p. 1248-1258, 2014.

• FAN, YIN ; WALISH, JOSEPH J. ; TANG, SHENGCHANG ; OLSEN, BRADLEY D. ; THOMAS, EDWIN L. . Defects, Solvent Quality, and Photonic Response in Lamellar Block Copolymer Gels. Macromolecules (Print) , v. 47, p. 1130-1136, 2014.

• TANG, SHENGCHANG ; GLASSMAN, MATTHEW J. ; LI, SHUAILI ; SOCRATE, SIMONA ; OLSEN, BRADLEY D. . Oxidatively Responsive Chain Extension to Entangle Engineered Protein Hydrogels. Macromolecules (Print) , v. 47, p. 791-799, 2014.

• KIM, MINKYU ; GKIKAS, MANOS ; HUANG, AARON ; KANG, JEON WOONG ; SUTHIWANGCHAROEN, NISARAPORN ; NAGARAJAN, RAMANATHAN ; OLSEN, BRADLEY D. . Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer. Chemical Communications (London. 1996. Print) , v. 50, p. 5345, 2014.

• THOMAS, CARLA S. ; OLSEN, BRADLEY D. . Coil fraction-dependent phase behaviour of a model globular protein-polymer diblock copolymer. Soft Matter (Print) , v. 10, p. 3093, 2014.

• SHIN, HYEONGHO ; OLSEN, BRADLEY D. ; KHADEMHOSSEINI, ALI . Gellan gum microgel-reinforced cell-laden gelatin hydrogels. J MATER CHEM B , v. 2, p. 2508, 2014.

• TANG, SHENGCHANG ; OLSEN, BRADLEY D. . Controlling topological entanglement in engineered protein hydrogels with a variety of thiol coupling chemistries. Frontiers in Chemistry , v. 2, p. 1, 2014.

• RAMAN, VINAY ; HATTON, T. ALAN ; OLSEN, BRADLEY D. . Kinetics of Magnetic Field-Induced Orientational Ordering in Block Copolymer/Superparamagnetic Nanoparticle Composites. MACROMOLECULAR RAPID COMMUNICATIONS , v. 35, p. 2005-2011, 2014.

• OLSEN, BRADLEY D. . Engineering materials from proteins. AIChE Journal , v. 59, p. 3558-3568, 2013.

• THOMAS, CARLA S. ; XU, LIZA ; OLSEN, BRADLEY D. . Effect of Small Molecule Osmolytes on the Self-Assembly and Functionality of Globular Protein-Polymer Diblock Copolymers. Biomacromolecules , v. 14, p. 3064-3072, 2013.

• OLSEN, BRADLEY D. . Self-Assembly of Globular-Protein-Containing Block Copolymers. Macromolecular Chemistry and Physics (Print) , v. 214, p. 1659-1668, 2013.

• RAMAN, VINAY ; SHARMA, RAVI ; HATTON, T. ALAN ; OLSEN, BRADLEY D. . Magnetic Field Induced Morphological Transitions in Block Copolymer/Superparamagnetic Nanoparticle Composites. ACS Macro Letters , v. 2, p. 655-659, 2013.

• WANG, MUZHOU ; TIMACHOVA, KSENIA ; OLSEN, BRADLEY D. . Diffusion Mechanisms of Entangled Rod-Coil Diblock Copolymers. Macromolecules (Print) , v. 46, p. 5694-5701, 2013.

• OLSEN, B. D. ; JOHNSON, J. A. . Reply to Stadler: Combining network disassembly spectrometry with rheology/spectroscopy. Proceedings of the National Academy of Sciences of the United States of America , v. 110, p. E1973-E1973, 2013.

• KIM, MINKYU ; TANG, SHENGCHANG ; OLSEN, BRADLEY D. . Physics of engineered protein hydrogels. Journal of Polymer Science. Part B, Polymer Physics , v. 51, p. 587-601, 2013.

• GLASSMAN, MATTHEW J. ; CHAN, JACQUELINE ; OLSEN, BRADLEY D. . Reinforcement of Shear Thinning Protein Hydrogels by Responsive Block Copolymer Self-Assembly. Advanced Functional Materials (Print) , v. 23, p. 1182-1193, 2013.

• WANG, MUZHOU ; TIMACHOVA, KSENIA ; OLSEN, BRADLEY D. . Experimental Measurement of Coil-Rod-Coil Block Copolymer Tracer Diffusion through Entangled Coil Homopolymers. Macromolecules (Print) , v. 46, p. 1651-1658, 2013.

• GLASSMAN, MATTHEW J. ; OLSEN, BRADLEY D. . Structure and mechanical response of protein hydrogels reinforced by block copolymer self-assembly. Soft Matter (Print) , v. 9, p. 6814, 2013.

• XIA, YAN ; TANG, SHENGCHANG ; OLSEN, BRADLEY D. . Site-specific conjugation of RAFT polymers to proteins via expressed protein ligation. Chemical Communications (London. 1996. Print) , v. 49, p. 2566, 2013.

• LAM, CHRISTOPHER N. ; OLSEN, BRADLEY D. . Phase transitions in concentrated solution self-assembly of globular protein-polymer block copolymers. Soft Matter (Print) , v. 9, p. 2393, 2013.

• RAMAN, VINAY ; BOSE, ARIJIT ; OLSEN, BRADLEY D. ; HATTON, T. ALAN . Long-Range Ordering of Symmetric Block Copolymer Domains by Chaining of Superparamagnetic Nanoparticles in External Magnetic Fields. Macromolecules (Print) , v. 45, p. 9373-9382, 2012.

• ZHOU, H. ; WOO, J. ; COK, A. M. ; WANG, M. ; OLSEN, B. D. ; JOHNSON, J. A. . Counting primary loops in polymer gels. Proceedings of the National Academy of Sciences of the United States of America , v. 109, p. 19119-19124, 2012.

• THOMAS, CARLA S. ; XU, LIZA ; OLSEN, BRADLEY D. . Kinetically Controlled Nanostructure Formation in Self-Assembled Globular Protein-Polymer Diblock Copolymers. Biomacromolecules , v. 13, p. 2781-2792, 2012.

• KIM, BOKYUNG ; LAM, CHRISTOPHER N. ; OLSEN, BRADLEY D. . Nanopatterned Protein Films Directed by Ionic Complexation with Water-Soluble Diblock Copolymers. Macromolecules (Print) , v. 45, p. 4572-4580, 2012.

• WANG, MUZHOU ; ALEXANDER-KATZ, ALFREDO ; OLSEN, BRADLEY D. . Diffusion of Entangled Rod-Coil Block Copolymers. ACS Macro Letters , v. 1, p. 676-680, 2012.

• SHIN, HYEONGHO ; OLSEN, BRADLEY D. ; KHADEMHOSSEINI, ALI . The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules. Biomaterials (Guildford) , v. 33, p. 3143-3152, 2012.

• THOMAS, CARLA S. ; GLASSMAN, MATTHEW J. ; OLSEN, BRADLEY D. . Solid-State Nanostructured Materials from Self-Assembly of a Globular Protein-Polymer Diblock Copolymer. ACS Nano , v. 5, p. 5697-5707, 2011.

• OLSEN, BRADLEY D. ; KORNFIELD, JULIA A. ; TIRRELL, DAVID A. . Yielding Behavior in Injectable Hydrogels from Telechelic Proteins. Macromolecules (Print) , v. 43, p. 9094-9099, 2010.

• OLSEN, BRADLEY D. ; GU, XUN ; HEXEMER, ALEXANDER ; GANN, ELIOT ; SEGALMAN, RACHEL A. . Liquid Crystalline Orientation of Rod Blocks within Lamellar Nanostructures from Rod−Coil Diblock Copolymers. Macromolecules (Print) , v. 43, p. 6531-6534, 2010.

• XIA, YAN ; OLSEN, BRADLEY D. ; KORNFIELD, JULIA A. ; GRUBBS, ROBERT H. . Efficient Synthesis of Narrowly Dispersed Brush Copolymers and Study of Their Assemblies: The Importance of Side Chain Arrangement. Journal of the American Chemical Society (Print) , v. 131, p. 18525-18532, 2009.

• OLSEN, BRADLEY D. ; LI, XUEFA ; WANG, JIN ; SEGALMAN, RACHEL A. . Near-surface and internal lamellar structure and orientation in thin films of rod-coil block copolymers. Soft Matter (Print) , v. 5, p. 182-192, 2009.

• OLSEN, BRADLEY D. ; TECLEMARIAM, NERAYO P. ; MULLER, SUSAN J. ; SEGALMAN, RACHEL A. . Rheological properties and the mechanical signatures of phase transitions in weakly-segregated rod-coil block copolymers. Soft Matter (Print) , v. 5, p. 2453, 2009.

• OLSEN, BRADLEY D. ; SHAH, MANAS ; GANESAN, VENKAT ; SEGALMAN, RACHEL A. . Universalization of the Phase Diagram for a Model Rod−Coil Diblock Copolymer. Macromolecules (Print) , v. 41, p. 6809-6817, 2008.

• OLSEN, B ; SEGALMAN, R . Self-assembly of rod-coil block copolymers. Materials Science & Engineering. R, Reports , v. 62, p. 37-66, 2008.

• OLSEN, BRADLEY D. ; TONEY, MICHAEL F. ; SEGALMAN, RACHEL A. . Square Grains in Asymmetric Rod−Coil Block Copolymers. Langmuir , v. 24, p. 1604-1607, 2008.

• OLSEN, BRADLEY D. ; ALCAZAR, DANIEL ; KRIKORIAN, VAHIK ; TONEY, MICHAEL F. ; THOMAS, EDWIN L. ; SEGALMAN, RACHEL A. . Crystalline Structure in Thin Films of DEH−PPV Homopolymer and PPV -PI Rod−Coil Block Copolymers. Macromolecules (Print) , v. 41, p. 58-66, 2008.

• OLSEN, BRADLEY D. ; SEGALMAN, RACHEL A. . Nonlamellar Phases in Asymmetric Rod−Coil Block Copolymers at Increased Segregation Strengths. Macromolecules (Print) , v. 40, p. 6922-6929, 2007.

• TAO, YUEFEI ; ZOHAR, HAGAR ; OLSEN, BRADLEY D. ; SEGALMAN, RACHEL A. . Hierarchical Nanostructure Control in Rod−Coil Block Copolymers with Magnetic Fields. Nano Letters (Print) , v. 7, p. 2742-2746, 2007.

• OLSEN, BRADLEY D. ; LI, XUEFA ; WANG, JIN ; SEGALMAN, RACHEL A. . Thin Film Structure of Symmetric Rod−Coil Block Copolymers. Macromolecules (Print) , v. 40, p. 3287-3295, 2007.

• TAO, YUEFEI ; OLSEN, BRADLEY D. ; GANESAN, VENKAT ; SEGALMAN, RACHEL A. . Domain Size Control in Self-Assembling Rod−Coil Block Copolymer and Homopolymer Blends. Macromolecules (Print) , v. 40, p. 3320-3327, 2007.

• OLSEN, BRADLEY D. ; SEGALMAN, RACHEL A. . Phase Transitions in Asymmetric Rod−Coil Block Copolymers. Macromolecules (Print) , v. 39, p. 7078-7083, 2006.

• OLSEN, BRADLEY D. ; JANG, SUNG-YEON ; LÜNING, JAN M. ; SEGALMAN, RACHEL A. . Higher Order Liquid Crystalline Structure in Low-Polydispersity DEH-PPV. Macromolecules (Print) , v. 39, p. 4469-4479, 2006.

• LAU, KENNETH K.S. ; MAO, YU ; PRYCE LEWIS, HILTON G. ; MURTHY, SHASHI K. ; OLSEN, BRAD D. ; LOO, LESLIE S. ; GLEASON, KAREN K. . Polymeric nanocoatings by hot-wire chemical vapor deposition (HWCVD). Thin Solid Films , v. 501, p. 211-215, 2006.

• OLSEN, BRADLEY D. ; SEGALMAN, RACHEL A. . Structure and Thermodynamics of Weakly Segregated Rod−Coil Block Copolymers. Macromolecules (Print) , v. 38, p. 10127-10137, 2005.

• MURTHY, SHASHI K. ; OLSEN, BRADLEY D. ; GLEASON, KAREN K. . Peptide Attachment to Vapor Deposited Polymeric Thin Films. Langmuir , v. 20, p. 4774-4776, 2004.

• MURTHY, SHASHI K. ; OLSEN, BRADLEY D. ; GLEASON, KAREN K. . Effect of filament temperature on the chemical vapor deposition of fluorocarbon-organosilicon copolymers. Journal of Applied Polymer Science (Print) , v. 91, p. 2176-2185, 2004.

• LIN, JIAN ; MURTHY, SHASHI K. ; OLSEN, BRADLEY D. ; GLEASON, KAREN K. ; KLIBANOV, ALEXANDER M. . Making thin polymeric materials, including fabrics, microbicidal and also water-repellent. Biotechnology Letters , v. 25, p. 1661-1665, 2003.

• MURTHY, SHASHI K. ; OLSEN, BRADLEY D. ; GLEASON, KAREN K. . Initiation of Cyclic Vinylmethylsiloxane Polymerization in a Hot-Filament Chemical Vapor Deposition Process. Langmuir , v. 18, p. 6424-6428, 2002.

• BRADLEY D OLSEN . Towards a Universal Phase Diagram for Functional Rod-Coil Block Copolymers. 2008. (Apresentação de Trabalho/Seminário).

• BRADLEY D OLSEN . Towards a Universal Phase Diagram for Functional Rod-Coil Block Copolymers. 2008. (Apresentação de Trabalho/Seminário).

Projetos de pesquisa

• 2015 - Atual

  Simple Engieered Biological Motifs for Complex Hydrogel Function, Descrição: This multidisciplinary team sits at the intersection of science and engineering, and seeks to establish the fundamental knowledge base needed to inspire cutting-edge practical applications of complex biological hydrogels.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (4) . , Integrantes: Bradley Olsen - Coordenador / Katharina Ribbeck - Integrante / Timothy Lu - Integrante / Paula T. Hammond - Integrante / Alan Grodzinsky - Integrante / Jeremiah Johnson - Integrante / Niels Holten-Andersen - Integrante / Patrick Doyle - Integrante., Financiador(es): The National Science Foundation - Remuneração.

• 2015 - Atual

  Artifically Engineered Proteins as Barrier Materials, Descrição: This project aims to explore the use of artificially engineered proteins as barrier materials in food packaging.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (4) . , Integrantes: Bradley Olsen - Coordenador / Vilasia Guimaraes Martins - Integrante / Carlos Prentice Hernandez - Integrante., Financiador(es): Massachusetts Institute of Technology - Remuneração.

• 2014 - 2014

  Solvent-Solubilized Enzymes for Bulk Defeat of Chemical Agent Stocks, Descrição: The project will be primarily responsible for the development of new enzyme-polymer conjugates that can enable the solubilization and dispersal of enzymes within hydrophobic chemical agents.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador / Jeremy Walker - Integrante., Financiador(es): Defense Advanced Research Projects Agency - Remuneração.

• 2014 - 2014

  Agent-Exposure Surveillance and Proteictive Integrated Suits, Descrição: This project aims to develop sensing patches that can detect and alert the wearer to exposure to harmful agents.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador / Jeremy Walker - Integrante., Financiador(es): Defense Advanced Research Projects Agency - Remuneração.

• 2014 - Atual

  Protein-Based Polyurethanes, Descrição: Polyurethanes (PUs) are one of the most pervasive engineering plastics in our society, finding widespread potential application in the urban habitat (insulation, coatings, adhesives), automotive parts (foam for seats, impact panels), and insulation (spray foam). In particular, the role of PUs as insulation materials has a large potential impact on MPP efforts to develop sustainable urban habitats, where a sustainably derived PU would enable reduced heating/cooling costs and lower energy consumption. The proposed work will take existing efforts on renewable polyurethanes in a transformative new direction, engineering renewable hard blocks from protein biomass to enable the first fully-renewable PU formulations for transportation and sustainable urban spaces.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador / Ana Vera Machado - Integrante., Financiador(es): Massachusetts Institute of Technology - Remuneração.

• 2014 - Atual

  Collaborative Work With Elizabeth Arden Corporation, Descrição: This project is developing new chemistries of application to cosmetic products.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Bradley Olsen - Coordenador., Financiador(es): Elizabeth Arden Corporation - Remuneração.

• 2014 - Atual

  Sloan Research Fellowship, Descrição: This fellowship provides support for research activities in Olsen's lab.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador., Financiador(es): Sloan Foundation - Remuneração.

• 2013 - Atual

  BIOREFINERY - Integrated Sustainable Processes for Biomass Conversion to Biomaterials, Biofuels, and Fertilizer, Descrição: The proposed research will conceptually generate and assess novel processes to convert renewable biomass into biofuels, bio-derived materials and fertilizer, using the biorefinery concept. Feedstock will include indigenous resources in Abu Dhabi, such as the organic fraction of municipal solid wastes in addition to other agricultural wastes and purpose-grown micro- and macro-algae. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Doutorado: (5) . , Integrantes: Bradley Olsen - Coordenador / Yuriy Roman - Integrante / George Stephanopoulos - Integrante / Kristala L. J. Prather - Integrante., Financiador(es): Masdar Institute - Remuneração.

• 2013 - Atual

  Responsive Hybrid Block Copolymer Photonic Crystals, Descrição: This project will investigate new methods for triggering transitions in block copolymer photonic crystals through the engineering of responsive hybrid materials systems. Mechanisms to change both layer thickness and refractive index will be explored.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (2) . , Integrantes: Bradley Olsen - Coordenador / THOMAS, EDWIN L. - Integrante., Financiador(es): Natick Soldier RD&E Center - Remuneração.

• 2013 - Atual

  An Autonomous, Respnsive, Molecular Second Skin, Descrição: Demands on the modern Warfighter require chemical biological (CB) protection that is very lightweight and decreases thermal load. The ideal protection would, in essence, be a ?second skin.? We propose to develop adaptive, responsive materials toward such a second skin, with the material design based on the use of novel, responsive polymer gels, including hydrogels (HGs), organohydrogels (OHGs) and metal organic frameworks (MOFs). These modular responsive gels will provide the sensing, transduction, protection and decontamination functions to the material in an autonomous manner. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Doutorado: (3) . , Integrantes: Bradley Olsen - Coordenador / NAGARAJAN, RAMANATHAN - Integrante / HATTON, T. ALAN - Integrante / Eugene Wilusz - Integrante / Matthew E. Helgeson - Integrante / David J. McGarvey - Integrante / William R. Creasy - Integrante / Jeffrey R. Owens - Integrante., Financiador(es): Defense Threat Reduction Agency - Remuneração.

• 2013 - Atual

  SNM: Inverse Design of Nanostructured Heterogeneous Materials, Descrição: Here, we propose to develop the computational and experimental tools to design arbitrary 3D heterogeneous nanostructured films by solving the inverse self-assembly problem. Such tools will permit a priori selection of arbitrary target patterns, and will yield a precisely defined template on which such complex structures will form. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) / Doutorado: (6) . , Integrantes: Bradley Olsen - Integrante / ALEXANDER-KATZ, ALFREDO - Coordenador / Caroline Ross - Integrante / Karl Berggren - Integrante., Financiador(es): National Science Foundation - Remuneração.

• 2013 - Atual

  DMREF: Analysis and Optimization of Polymer Netowrk Microstructure for Emerging Applications, Descrição: This project will build highly collaborative, synergistic interactions between the Johnson and Olsen groups with a unified goal to develop novel experimental, synthetic, computational, and theoretical methods that will provide unprecedented understanding of the nature of molecular topologies in polymer networks. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Doutorado: (2) . , Integrantes: Bradley Olsen - Integrante / JOHNSON, JEREMIAH A. - Coordenador., Financiador(es): National Science Foundation - Remuneração.

• 2013 - Atual

  Nuclear Pore and Mucin Barrier Mimics as Selective Filters for Biological Agents, Descrição: Our goal is to develop artificial protein and synthetic polymer building blocks that mimic the design of nuclear pore and mucin hydrogel barriers, incorporating design features of both to allow their transport and separation properties to be applied in sensing of, and defense against, biological threats. To achieve this aim, we will engineer artificial protein polymers and synthetic polymer models that simulate the structure of the nucleopore membranes and mucins. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Doutorado: (4) . , Integrantes: Bradley Olsen - Coordenador / Katharina Ribbeck - Integrante., Financiador(es): Defense Threat Reduction Agency - Remuneração.

• 2013 - Atual

  CAREER: Self-Assembly of Fusion Proteins to Form Biofunctional Materials, Descrição: This proposal will investigate the potential of fusion proteins to direct the self-assembly of globular proteins in a manner analogous to diblock copolymers. The use of fusion proteins will enable the easy preparation of site-specific conjugates, using genetic engineering to control molecular structure. The thermodynamics of globular-coil protein blends will be explored to understand how the sequence of a coillike protein affects its miscibility with globular proteins, allowing a set of proteins with potential for directing self-assembly to be identified. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador., Financiador(es): National Science Foundation - Remuneração.

• 2012 - 2014

  Design of Nanostructured Enzyme-Micelle Conjugates for Decontamination of Aircraft Surfaces, Descrição: We propose a novel, exploratory research program to use enzymatic decontamination to address the critical gap of the absence of an effective decon formulation for aircraft. Current aircraft decon is limited to the use of hot soapy water. Enzyme formulations have potential to far exceed the performance of existing soapy water decontamination of aircraft by allowing simultaneous physical removal and chemical degradation of the CWA.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador / NAGARAJAN, RAMANATHAN - Integrante., Financiador(es): Defense Threat Reduction Agency - Remuneração.

• 2012 - Atual

  Molecular to Macroscale Design of Tissue Surrogate Gels for Injury Models, Descrição: There are currently no synthetic materials that meet this requirement for soft-tissues including heart and brain, due chiefly to challenges in robust gel design and in multiscale mechanical characterization of both gels and tissues. Here our objectives are to synthesize,characterize quantitatively, and model computationally the mechanical deformation of novel hybrid gels as tissue surrogates for soft tissues in the head and torso, from the molecular to macroscale. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (6) . , Integrantes: Bradley Olsen - Coordenador / Krystyn Van Vliet - Integrante / Keith A Nelson - Integrante / Raul Radovitzky - Integrante., Financiador(es): Army Research Office - Remuneração.

• 2012 - Atual

  Nanostructured Biomaterials for the Treatment of Hemorrhagic Shock, Descrição: In this proposal, we aim to develop a nanostructured hemostatic gel that can both stop the flow of blood and induce subsequent regeneration of tissue.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (3) / Doutorado: (3) . , Integrantes: Bradley Olsen - Coordenador / MCKINLEY, GARETH H. - Integrante / KHADEMHOSSEINI, ALI - Integrante., Financiador(es): Army Research Office - Remuneração.

• 2012 - Atual

  Thin Film Self-Assembly of Globular Protein-Polymer Block Copolymers, Descrição: This proposal will explore the self-assembly of globular protein-polymer diblock copolymers as a method for controlling the nanostructure of protein-based materials in thin films, developing the fundamental scientific knowledge necessary for the application of these systems to Air Force technologies. Three key scientific challenges will be addressed in order to understand the fundamental thermodynamics of copolymer self-assembly in thin films: engineering the surface segregation of blocks to the film interfaces to control film morphology, developing annealing methods that control structure formation while preserving protein function, and optimizing protein activity and stability within the block copolymer materials.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (2) . , Integrantes: Bradley Olsen - Coordenador., Financiador(es): Air Force Office of Scientific Research - Remuneração.

• 2011 - 2014

  Artificial Chlorosomes for Controlled Exciton Transport, Descrição: Here, we propose to develop antenna structures that are hierarchically structured through a combination of J-aggregate formation and block copolymer self-assembly to maximize energy flows in the form of electron-hole pairs (excitons), and could eventually be used to direct also electrons and/or holes. The molecular control of the transport of excitons can revolutionize fields in which photon harvesting and energy conversion are key elements.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Doutorado: (2) . , Integrantes: Bradley Olsen - Integrante / ALEXANDER-KATZ, ALFREDO - Coordenador., Financiador(es): Department of Energy - Remuneração.

• 2011 - 2012

  Imaging of Nanostructured Hydrogels, Descrição: This proposal focused on the application of electron microscopy to image nanostructured hydrogel materials, providing insights into their structure-property relationships.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador., Financiador(es): National Science Foundation - Remuneração.

• 2011 - Atual

  Thermodynamics of Self-Assembly in Globular Protein-Polymer Conjugates, Descrição: This project addresses fundamental scientific challenges that will enable the application of globular protein self-assemblies for energy applications including the effect of protein shape on self-assembly, engineering protein interactions to control self-assembly, and the development and application of neutron methods to study the properties of biohybrid systems.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (4) / Doutorado: (3) . , Integrantes: Bradley Olsen - Coordenador., Financiador(es): Department of Energy - Remuneração.

• 2010 - 2012

  Mechanisms of Molecular Motion in Polymers With Nonuniform Stiffness, Descrição: This proposal developed a hybrid theoretical and experimental effort to understand the dynamics of hybrid polymers containing both rigid ?rodlike? and flexible ?coillike? blocks in dilute solutions and in entangled melts. Experimental measurements of translational and rotational diffusion coefficients will be performed in both dilute solution and entangled samples using optical scattering and microscopy techniques to elucidate the dependence on the molecular weight and fraction of flexible polymer in the chain. Coarse-grained simulation and analytical approximations to a set of Langevin equations will be used to interpret measurements in dilute solution, while modified reptation models will be used to interpret entangled regime behavior. These results will provide the first step towards understanding the molecular-level dynamics in rod-coil polymer systems, enabling further progress in the engineering of semiconducting polymers and protein-synthetic polymer conjugates for organic electronics and biomedical applications.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) / Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador., Financiador(es): Massachusetts Institute of Technology - Remuneração.

• 2010 - 2012

  Responsively Toughening Injectable Hydrogels, Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (3) / Doutorado: (2) . , Integrantes: Bradley Olsen - Coordenador., Financiador(es): Army Research Office - Remuneração.

• 2010 - 2012

  Self-Assembled Polymer-Enzyme Nanostructures for Low Temperature CO2 Reduction, Descrição: This proposal explores a novel platform for the development of bioelectrocatalysts based on protein-polymer conjugate self-assembly into three-dimensional nanostructures that provide simultaneous control over electronic and diffusive transport, enzyme orientation, and total enzyme packing density. The fundamental thermodynamics of self-assembly in polymer-enzyme systems will be explored, and promising nanostructures will be translated to prototype systems.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador., Financiador(es): Massachusetts Institute of Technology - Remuneração.

• 2010 - 2011

  MIT-DuPont Fellowship, Descrição: This fellowship supports work developing new models for the dynamic behavior of polymers containing rigid and flexible blocks.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Bradley Olsen - Coordenador., Financiador(es): DuPont - Bolsa.

• 2008 - 2009

  Thermodynamics of Gelation and Dynamic Properties of Biosynthetic Protein Hydrogels, Descrição: Because they have properties similar to biological tissues and are often biocompatible, hydrogels have found widespread use in biomedical applications such as drug delivery and tissue engineering. Use of hydrogels in these applications requires control over the thermodynamics of gelation and swelling as well as the dynamic properties of the gel. The proposed research will use both experiment and theory to develop a better understanding of the relationships between protein structure and gel properties in protein hydrogels. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Bradley Olsen - Coordenador / KORNFIELD, JULIA A. - Integrante / TIRRELL, DAVID A. - Integrante / Zhen-Gang Wang - Integrante., Financiador(es): Department of Health and Human Services - Bolsa.

• 2008 - 2009

  Structure and Dynamics of Telechelic Protein Hydrogels, Descrição: In order to guide the responses of cells to tissue engineering materials, it is necessary to control their structure and function on a variety of length scales. Biosynthetic protein hydrogels provide an ideal system for exercising this type of control in materials because they provide easy incorporation of biofunctional molecular signals while at the same time allowing polymer engineering principles to be used to control their nanoscale to macroscale structure. Our studies focus on a telechelic protein system, developed ten years ago by the Tirrell lab, where a flexible protein midblock is linked to leucine zippers on both ends.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Bradley Olsen - Coordenador / KORNFIELD, JULIA A. - Integrante / TIRRELL, DAVID A. - Integrante / Zhen-Gang Wang - Integrante., Financiador(es): Beckman Research Institute - Bolsa.

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