Vanessa Marensi

Vanessa has over a decade of experience in Biochemical Pharmacology, Pharmacy and Human Physiology. Her research focuses on the mechanism by which cancers develop resistance to drug treatment. During her PhD at the University of Alberta (Canada),Vanessas research is focused on translating fundamental cellular mechanisms controlling tumour resistance and relapse to clinical applications. She searches for novel therapeutic strategies to overcome chemoresistance and improve patient outcomes. Some of her current work and interests include, but are not limited to: Targeted therapy and personalised medicine-based approaches to cancer treatment. Repurposing of commercially available drugs and discovery of novel compounds from natural sources as potential therapeutic agents The impact of clinically relevant mutations and post translational modifications in the evolutionary process of cancer heterogeneity, progression, and resistance to target therapy in acute myeloid leukaemia (AML) Investigate how fatty acids regulate cell function by targeting specific sites on metabolic enzymes and oncoproteins associated with drug resistance. Most of them are responsive to changes in the redox environment.

Informações coletadas do Lattes em 18/11/2025

Acadêmico

Formação acadêmica

Doutorado em Physiology

2011 - 2017

University of Alberta
Título: Glutathione Transferase P1 is Modified by Palmitate
Orientador: Elaine M. Leslie
Coorientador: Luc Berthiaume. Bolsista do(a): Canadian Institute of Health Research, CIHR, Canadá. Palavras-chave: Cell Biology; Glutathione S-tranferase; Cancer; Toxicology; Palmitoylation; Multidrug Resistance Protein - MRP.

Mestrado profissional em Biomedical Data Processing

2007 - 2007

Universtità degli Studi di Verona
Título: Neurodegenerative process in an animal model of epilepsy, Ano de Obtenção:
Orientador: Paulo Francesco Fabene
Bolsista do(a): Fondo Sociale Europeo, FSE, Itália.

Graduação em Pharmacy

1998 - 2004

Universidade do Vale do Itajaí
Título: Ethnopharmacognostic survey on botanical compendia for potential cosmeceutic species from Atlantic Forest
Orientador: Maique Weber Biavatti

Formação complementar

2014 - 2014

Summer Microscopy Workshop. (Carga horária: 40h). , University of Alberta, UALBERTA, Canadá.

2013 - 2013

Animais de Laboratorio - Biologia, Manejo e Etica. (Carga horária: 20h). , Universidade do Vale do Itajaí, UNIVALI, Brasil.

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Espanhol

Compreende Bem, Fala Pouco, Lê Bem, Escreve Razoavelmente.

Italiano

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Áreas de atuação

Grande área: Ciências Biológicas / Área: Farmacologia / Subárea: Farmacologia Bioquímica e Molecular.

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Química de Macromoléculas/Especialidade: Lipídeos.

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Química de Macromoléculas/Especialidade: Proteínas.

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Enzimologia.

Grande área: Ciências Biológicas / Área: Genética / Subárea: Genética Humana e Médica.

Grande área: Ciências Biológicas / Área: Farmacologia / Subárea: Toxicologia.

Organização de eventos

MARENSI, V. . 1st International Symposium of the Toxicology Research Group. 2013. (Outro).

Participação em eventos

CRINA - Cancer Research Institute of Northern Alberta.Glutathione S-transferases P1 (GSTP1) is post-translational modified and regulated by palmitate.. 2014. (Simpósio).

Woman and Children's Health Research Institute.Characterizing the post-translational modification of placental glutathione S-transferase P1 (GSTP1) by fatty acids.. 2014. (Simpósio).

Orientou

Katie Eppler

Mutating Lys residues on GSTP1 for post-translational modification charachterization; 2014; Iniciação Científica - University of Alberta; Orientador: Vanessa Marensi;

Daniela Hernandéz

Identification of the Sumoylation Binding Sites of GSTP1; 2014; Iniciação Científica - University of Alberta, Alberta Innovates Health Solutions; Orientador: Vanessa Marensi;

Rebecca Zuk

Mutating Glutathione S-Transferase (GSTP1) to identify the binding site of small ubiquitin modifier (SUMO); 2013; Iniciação Científica - University of Alberta, Alberta Innovates Health Solutions; Orientador: Vanessa Marensi;

Produções bibliográficas

BIAVATTI, MAIQUE W. ; MARENSI, VANESSA ; LEITE, SILVANA N. ; REIS, ADEMIR . Ethnopharmacognostic survey on botanical compendia for potential cosmeceutic species from Atlantic Forest. Revista Brasileira de Farmacognosia (Impresso) , v. 17, p. 640-653, 2007.
MARENSI, V. ; KEESHAN, K. R. ; MACEWAN, D. J. . Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors. Biochemical Pharmacology.
MARENSI, V. . Redox, cysteines, and kinases?A triad sustaining myeloid leukemia. Advances in Cancer Research.
GEIB, T. ; LENTO, C. ; MARENSI, V. ; THULASINGAM, M. ; HAEGGSTROM, J. Z. ; OLSSON, M. ; WILSON, D. J. ; LESLIE, E. M. ; SLENO, L. . Determining site occupancy of acetaminophen covalent binding to target proteins in vitro. Analytical Science Advances.
SHUKALEK, C. B. ; SWANLUND, D. P. ; ROUSSEAU, R. K. ; WEIGL, K. E. ; MARENSI, V. ; COLE, S. P. ; LESLIE, E. M. . Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23. Molecular Pharamcology.
HEALY, F. ; TURNER, A. L. ; MARENSI, V. ; MACEWAN, D. J. . Vanessa Marensi Mediating Kinase Activity in Ras-Mutant Cancer: Potential for An Individualised Approach?. Frontiers in Pharmacology.
BIAVATTI, MAIQUE W. ; LEITE, S. N. ; MARENSI, V. ; REIS, A. . Ethnopharmacognostic survey on botanical compendia for potential cosmeceutic species from Atlantic Forest. Revista Brasileira de Farmacognosia.
BANERJEE, M. ; MARENSI, V. ; CONSEIL, G. ; LE, X. C. ; COLE, S. P. ; LESLIE, E. M. . Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions. Biochemical Pharmacology.
MARENSI, V. . Glutathione S-Transferase P1 is strongly associated with cellular membranes and modified by palmitate.. 2014. (Apresentação de Trabalho/Seminário).
MARENSI, V. ; YAP, M. ; QAZI, S. S. ; BERTHIAUME, L. G. ; LESLIE, E. M. . GLUTATHIONE TRANSFERASE P1 (GSTP1) IS STRONGLY ASSOCIATED WITH CELLULAR MEMBRANES AND MODIFIED BY PALMITATE. 2013. (Apresentação de Trabalho/Congresso).
MARENSI, V. . Glutathione S-Transferase P1 and its association with the plasma membrane.. 2013. (Apresentação de Trabalho/Seminário).
MARENSI, V. . Glutathione S-Transferase P1 and its association with the plasma membrane.. 2013. (Apresentação de Trabalho/Seminário).
MARENSI, V. . Glutathione S-Transferase P1 and its association with the plasma membrane. 2013. (Apresentação de Trabalho/Simpósio).
MARENSI, V. ; YAP, M. ; QAZI, S. S. ; BERTHIAUME, L. G. ; LESLIE, E. M. . GSTP1 is fatty acylated by palmitate and associates with cellular membranes. Drug Metabolism Reviews, 2014 (Published abstract).

Prêmios

2024

Nomination to Best Lecturer at CSU?s Annual 1839 Awards., University of Chester.

2023

Travel award, Bloom Appeal awards.

2021

Travel award, The Company of the Biologist (CoB).

2016

Travel award, American Society for Pharmacology and Experimental Therapeutics (ASPET).

2016

Best Poster Presentation, University of Alberta.

2016

Poster award, IRTG.

2014

Travel Award, 57th Annual Conference of the Canadian Society for Molecular Biosciences.

2014

Travel award, CSMB.

Histórico profissional

Experiência profissional

2011 - 2017

University of Alberta

Vínculo: Bolsista, Enquadramento Funcional: PhD Student

Outras informações:
Analysis of fatty-acylated protein by mass spectrometry.

Atividades

01/2013
Conselhos, Comissões e Consultoria, University Governance : Graduate Faculty Council.Cargo ou função, Academic Appeal Committee (AAC) Member ; Graduate students panel..
01/2014
Direção e administração, University of Alberta : Physiology Graduate Students Association ( PGSA).Cargo ou função, Vice-President of the Physiology Graduate Students Association (University of Alberta).
01/2013
Direção e administração, Faculty of Medicine and Dentistry.Cargo ou função, Tutorials and proctor co-coordinator for Physiology 210 (Undergraduate) . U of A..
01/2013
Conselhos, Comissões e Consultoria, University of Alberta : Physiology Graduate Students Association ( PGSA).Cargo ou função, VP External.

2022 - Atual

University of Liverpool

Vínculo: Honorary Lecturer, Enquadramento Funcional: Honorary Lecturer

2017 - 2022

University of Liverpool

Vínculo: Servidor Público, Enquadramento Funcional: Post Doctoral Research Associate, Carga horária: 40

2025 - Atual

Bangor University

Vínculo: Servidor Público, Enquadramento Funcional: Senior Lecturer, Carga horária: 40