David Ascher

Áreas de atuação

Produções bibliográficas

• PARK, YUMI PACITTO, ANGELA BAYLISS, TRACY CLEGHORN, LAURA A. T. WANG, ZHE HARTMAN, TRAVIS ARORA, KRITI IOERGER, THOMAS R. SACCHETTINI, JIM RIZZI, MENICO DONINI, STEFANO BLUNDELL, TOM L. Ascher, David B. RHEE, KYU BREDA, ARDALA ZHOU, NIAN DARTOIS, VERONIQUE JONNALA, SURENDRANADHA REDDY VIA, LAURA E. MIZRAHI, VALERIE EPEMOLU, OLA STOJANOVSKI, LASTE SIMEONS, FRED OSUNA-CABELLO, MARIA ELLIS, LUCY , et al. MACKENZIE, CLAIRE J. SMITH, ALASDAIR R. C. DAVIS, SUSAN H. MURUGESAN, DINAKARAN BUCHANAN, KIRSTEEN I. TURNER, PENELOPE A. HUGGETT, MARGARET ZUCCOTTO, FABIO REBOLLO-LOPEZ, MARIA JOSE LAFUENTE-MONASTERIO, MARIA JOSE SANZ, OLALLA DIAZ, GRACIA SANTOS LELIÈVRE, JOËL BALLELL, LLUIS SELENSKI, CAROLYN AXTMAN, MATTHEW GHIDELLI-DISSE, SONJA PFLAUMER, HANNAH BÖSCHE, MARKUS DREWES, GERARD FREIBERG, GAIL M. KURNICK, MATTHEW D. SRIKUMARAN, MYRON KEMPF, DALE J. GREEN, SIMON R. RAY, PETER C. READ, KEVIN WYATT, PAUL BARRY, CLIFTON E. BOSHOFF, HELENA I. ; Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against. ACS Infectious Diseases , v. 3, p. 18-33, 2017.

• SINGH, VINAYAK ; DONINI, STEFANO ; PACITTO, ANGELA ; SALA, CLAUDIA ; HARTKOORN, RUBEN C. ; DHAR, NEERAJ ; KERI, GYORGY ; Ascher, David B. ; MONDÉSERT, GUILLAUME ; VOCAT, ANTHONY ; LUPIEN, ANDRÉANNE ; SOMMER, RAPHAEL ; VERMET, HÉLÈNE ; LAGRANGE, SOPHIE ; BUECHLER, JOE ; WARNER, DIGBY F. ; MCKINNEY, JOHN D. ; PATO, JANOS ; COLE, STEWART T. ; BLUNDELL, TOM L. ; RIZZI, MENICO ; MIZRAHI, VALERIE . The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis. ACS Infectious Diseases , v. 3, p. 5-17, 2017.

• LIANG, S. ; ESSWEIN, S. R. ; OCHI, T. ; WU, Q. ; ASCHER, D. B. ; CHIRGADZE, D. ; SIBANDA, B. L. ; BLUNDELL, T. L. . Achieving selectivity in space and time with DNA double-strand-break response and repair: molecular stages and scaffolds come with strings attached. Structural Chemistry , v. 28, p. 161-171, 2017.

• PARKER, LORIEN J. ; BOCEDI, ALESSIO ; Ascher, David B. ; AITKEN, JADE B. ; HARRIS, HUGH H. ; LO BELLO, MARIO ; RICCI, GIORGIO ; MORTON, CRAIG J. ; PARKER, MICHAEL W. . Glutathione transferase P1-1 as an arsenic drug-sequestering enzyme. PROTEIN SCIENCE , v. 26, p. 317-326, 2017.

• CASEY, RUTH T. ; Ascher, David B. ; RATTENBERRY, ELEANOR ; IZATT, LOUISE ; ANDREWS, KATRINA A. ; SIMPSON, HELEN L. ; CHALLIS, BENJAMEN ; PARK, SOO-MI ; BULUSU, VENKATA R. ; LALLOO, FIONA ; PIRES, DOUGLAS E. V. ; WEST, HANNAH ; CLARK, GRAEME R. ; SMITH, PHILIP S. ; WHITWORTH, JAMES ; PAPATHOMAS, THOMAS G. ; TANIERE, PHILLIPE ; SAVISAAR, ROSINA ; HURST, LAURENCE D. ; WOODWARD, EMMA R. ; MAHER, EAMONN R. . SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity. Molecular Genetics & Genomic Medicine , v. InPres, p. InPress, 2017.

• JUBB, HARRY C ; HIGUERUELO, ALICIA P ; OCHOA-MONTAÑO, BERNARDO ; PITT, WILL R ; ASCHER, DAVID B ; BLUNDELL, TOM L . Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures. JOURNAL OF MOLECULAR BIOLOGY , v. 429, p. 365-371, 2017.

• SIBANDA, BANCINYANE L. ; CHIRGADZE, DIMITRI Y. ; Ascher, David B. ; BLUNDELL, TOM L. . DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Science (New York, N.Y.) , v. 355, p. 520-524, 2017.

• SOARDI, FERNANDA C. ; MACHADO-SILVA, ALICE ; LINHARES, NATÁLIA D. ; ZHENG, GE ; QU, QIANHUI ; PENA, HELOÍSA B. ; MARTINS, THAÍS M. M. ; VIEIRA, HELAINE G. S. ; PEREIRA, NÚBIA B. ; MELO-MINARDI, RAQUEL C. ; GOMES, CAROLINA C. ; GOMEZ, RICARDO S. ; GOMES, DAWIDSON A. ; PIRES, DOUGLAS E. V. ; Ascher, David B. ; YU, HONGTAO ; PENA, SÉRGIO D. J. . Familial STAG2 germline mutation defines a new human cohesinopathy. npj Genomic Medicine , v. 2, p. 7, 2017.

• PIRES, DOUGLAS E.V. ; Ascher, David B. . mCSM-NA: predicting the effects of mutations on protein-nucleic acids interactions. Nucleic Acids Research , v. InPres, p. InPress, 2017.

• SHARP, JULIE A. ; BRENNAN, AMELIA J. ; POLEKHINA, GALINA ; Ascher, David B. ; LEFEVRE, CHRISTOPHE ; NICHOLAS, KEVIN R. . Dimeric but not monomeric α-lactalbumin potentiates apoptosis by up regulation of ATF3 and reduction of histone deacetylase activity in primary and immortalised cells. CELLULAR SIGNALLING , v. 33, p. 86-97, 2017.

• PANDURANGAN, ARUN PRASAD ; Ascher, David B. ; THOMAS, SHERINE E. ; BLUNDELL, TOM L. . Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance. BIOCHEMICAL SOCIETY TRANSACTIONS , v. 45, p. 303-311, 2017.

• PIRES, DOUGLAS E. V. ; CHEN, JING ; BLUNDELL, TOM L. ; Ascher, David B. . In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity. Scientific Reports , v. 6, p. 19848, 2016.

• ANDREWS, KATRINA A ; VIALARD, LINDSEY ; ASCHER, DAVID B ; PIRES, DOUGLAS E V ; BRADSHAW, NICOLA ; COLE, TREVOR ; COOK, JACKIE ; IRVING, RICHARD ; KUMAR, AJITH ; LALLOO, FIONA ; IZATT, LOUISE ; GOUDIE, DAVID ; WOODWARD, EMMA R ; MAHER, EAMONN R . Tumour risks and genotype-phenotype-proteotype analysis of patients with germline mutations in the succinate dehydrogenase subunit genes SDHB, SDHC, and SDHD. Lancet (British edition) , v. 387, p. S19, 2016.

• PHELAN, JODY ; COLL, FRANCESC ; MCNERNEY, RUTH ; Ascher, David B. ; PIRES, DOUGLAS E. V. ; FURNHAM, NICK ; COECK, NELE ; HILL-CAWTHORNE, GRANT A. ; NAIR, MRIDUL B. ; MALLARD, KIM ; RAMSAY, ANDREW ; CAMPINO, SUSANA ; HIBBERD, MARTIN L. ; PAIN, ARNAB ; RIGOUTS, LEEN ; CLARK, TAANE G. . Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance. BMC Medicine , v. 14, p. 31, 2016.

• CHAN, LINDA J. ; Ascher, David B. ; YADAV, RAJBHARAN ; BULITTA, JURGEN B. ; WILLIAMS, CHARLOTTE C. ; PORTER, CHRISTOPHER J.H. ; LANDERSDORFER, CORNELIA B. ; KAMINSKAS, LISA M. . Conjugation of 10 kDa linear PEG onto trastuzumab Fab' is sufficient to significantly enhance lymphatic exposure while preserving in vitro biological activity. Molecular Pharmaceutics (Print) , v. 13, p. 1229-1241, 2016.

• PIRES, DOUGLAS E.V. ; Ascher, David B. . CSM-lig: a web server for assessing and comparing protein-small molecule affinities. Nucleic Acids Research , v. 44, p. W557-W561, 2016.

• PIRES, DOUGLAS E.V. ; Ascher, David B. . mCSM-AB: a web server for predicting antibody-antigen affinity changes upon mutation with graph-based signatures. Nucleic Acids Research , v. 44, p. W469-W473, 2016.

• PIRES, DOUGLAS E. V. ; BLUNDELL, TOM L. ; Ascher, David B. . mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance. Scientific Reports , v. 6, p. 29575, 2016.

• SILVINO, ANA CAROLINA RIOS ; COSTA, GABRIEL LUIZ ; ARAÚJO, FLÁVIA CAROLINA FAUSTINO DE ; ASCHER, DAVID BENJAMIN ; PIRES, DOUGLAS EDUARDO VALENTE ; FONTES, COR JESUS FERNANDES ; CARVALHO, LUZIA HELENA ; BRITO, CRISTIANA FERREIRA ALVES DE ; SOUSA, TAIS NOBREGA . Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses. Plos One , v. 11, p. e0160172, 2016.

• COELHO, M. B. ; ASCHER, D. B. ; GOODING, C. ; LANG, E. ; MAUDE, H. ; TURNER, D. ; LLORIAN, M. ; PIRES, D. E. V. ; ATTIG, J. ; SMITH, C. W. J. . Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins. BIOCHEMICAL SOCIETY TRANSACTIONS , v. 44, p. 1058-1065, 2016.

• WHITE, RHIANNON R. ; PONSFORD, AMY H. ; WEEKES, MICHAEL P. ; RODRIGUES, RACHEL B. ; Ascher, David B. ; MOL, MARCO ; SELKIRK, MURRAY E. ; GYGI, STEVEN P. ; SANDERSON, CHRISTOPHER M. ; ARTAVANIS-TSAKONAS, KATERINA . Ubiquitin-Dependent Modification of Skeletal Muscle by the Parasitic Nematode, Trichinella spiralis. PLoS Pathogens (Online) , v. 12, p. e1005977, 2016.

• Jubb, Harry C. ; PANDURANGAN, ARUN P. ; TURNER, MEGHAN A. ; OCHOA-MONTAÑO, BERNARDO ; BLUNDELL, TOM L. ; Ascher, David B. . Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY , v. InPres, p. InPress, 2016.

• KANO, FLORA S. ; SOUZA-SILVA, FLÁVIA A. ; TORRES, LETICIA M. ; LIMA, BARBARA A. S. ; SOUSA, TAÍS N. ; ALVES, JÉSSICA R. S. ; ROCHA, ROBERTO S. ; FONTES, COR J. F. ; SANCHEZ, BRUNO A. M. ; ADAMS, JOHN H. ; BRITO, CRISTIANA F. A. ; PIRES, DOUGLAS E. V. ; Ascher, David B. ; SELL, ANA MARIA ; CARVALHO, LUZIA H. . The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants. PLoS Neglected Tropical Diseases (Online) , v. 10, p. e0005177, 2016.

• HERMANS, STEFAN J. ; ASCHER, DAVID B. ; HANCOCK, NANCY C. ; HOLIEN, JESSICA K. ; MICHELL, BELINDA J. ; CHAI, SIEW YEEN ; MORTON, CRAIG J. ; PARKER, MICHAEL W. . Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides. Protein Science (Print) , v. 24, p. 190-199, 2015.

• KAMINSKAS, LISA M. ; MCLEOD, VICTORIA M. ; ASCHER, DAVID B. ; RYAN, GEMMA M. ; JONES, SETH ; HAYNES, JOHN M. ; TREVASKIS, NATALIE L. ; CHAN, LINDA J. ; SLOAN, ERICA K. ; FINNIN, BENJAMIN A. ; WILLIAMSON, MARK ; VELKOV, TONY ; WILLIAMS, ELIZABETH D. ; KELLY, BRIAN D. ; OWEN, DAVID J. ; PORTER, CHRISTOPHER J. H. . Methotrexate-Conjugated PEGylated Dendrimers Show Differential Patterns of Deposition and Activity in Tumor-Burdened Lymph Nodes after Intravenous and Subcutaneous Administration in Rats. Molecular Pharmaceutics (Print) , v. 12, p. 432-443, 2015.

• CALIPH, SUZANNE M. ; SHACKLEFORD, DAVID M. ; ASCHER, DAVID B. ; KAMINSKAS, LISA M. . Practical Lessons in Murine Thoracic Lymph Duct Cannulations: Observations in Female and Male Mice Across Four Different Strains That Impact on -Cannulatability-. Journal of Pharmaceutical Sciences , v. 104, p. 1207-1209, 2015.

• CHAN, LINDA J. ; BULITTA, JÜRGEN B. ; ASCHER, DAVID B. ; HAYNES, JOHN M. ; MCLEOD, VICTORIA M. ; PORTER, CHRISTOPHER J. H. ; WILLIAMS, CHARLOTTE C. ; KAMINSKAS, LISA M. . PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance after Subcutaneous Administration. Molecular Pharmaceutics (Print) , v. 12, p. 794-809, 2015.

• LANDERSDORFER, CORNELIA B. ; CALIPH, SUZANNE M. ; SHACKLEFORD, DAVID M. ; ASCHER, DAVID B. ; KAMINSKAS, LISA M. . PEGylated Interferon Displays Differences in Plasma Clearance and Bioavailability Between Male and Female Mice and Between Female Immunocompetent C57Bl/6J and Athymic Nude Mice. Journal of Pharmaceutical Sciences , v. 104, p. 1848-1855, 2015.

• PIRES, DOUGLAS E. V. ; BLUNDELL, TOM L. ; ASCHER, DAVID B. . pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures. Journal of Medicinal Chemistry , v. 58, p. 4066-4072, 2015.

• JUBB, HARRY ; BLUNDELL, TOM L. ; Ascher, David B. . Flexibility and small pockets at protein-protein interfaces: New insights into druggability. Progress in Biophysics and Molecular Biology , v. 119, p. 2-9, 2015.

• BLASZCZYK, MICHAL ; HARMER, NICHOLAS J. ; CHIRGADZE, DIMITRI Y. ; Ascher, David B. ; BLUNDELL, TOM L. . Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors. Progress in Biophysics and Molecular Biology , v. 118, p. 103-111, 2015.

• JAFRI, M. ; WAKE, N. C. ; ASCHER, D. B. ; PIRES, D. E. V. ; GENTLE, D. ; MORRIS, M. R. ; RATTENBERRY, E. ; SIMPSON, M. A. ; TREMBATH, R. C. ; WEBER, A. ; WOODWARD, E. R. ; DONALDSON, A. ; BLUNDELL, T. L. ; LATIF, F. ; MAHER, E. R. . Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma. Cancer Discovery , v. 5, p. 723-729, 2015.

• SIGURDARDOTTIR, ANNA GUDNY ; WINTER, ANJA ; SOBKOWICZ, ANNA ; FRAGAI, MARCO ; CHIRGADZE, DIMITRI ; ASCHER, DAVID ; BLUNDELL, TOM ; GHERARDI, ERMANNO . Exploring the chemical space of the lysine-binding pocket of the first kringle domain of Hepatocyte Growth Factor/Scatter Factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chemical Science , v. 6, p. 6147-6157, 2015.

• PACITTO, ANGELA ; Ascher, David B. ; WONG, LOUISE H. ; BLASZCZYK, BEATA K. ; NOOKALA, RAVI K. ; ZHANG, NIANSHU ; DOKUDOVSKAYA, SVETLANA ; LEVINE, TIM P. ; BLUNDELL, TOM L. . Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein. OPEN BIOL , v. 5, p. 150174, 2015.

• NEMETHOVA, MARTINA RADVANSZKY, JAN KADASI, LUDEVIT ASCHER, DAVID B PIRES, DOUGLAS E V BLUNDELL, TOM L PORFIRIO, BERARDINO MANNONI, ALESSANDRO SANTUCCI, ANNALISA MILUCCI, LIA SESTINI, SILVIA BIOLCATI, GIANFRANCO SORGE, FIAMMETTA AURIZI, CATERINA AQUARON, ROBERT ALSBOU, MOHAMMED MARQUES LOURENÇO, CHARLES RAMADEVI, KANAKASABAPATHI RANGANATH, LAKSHMINARAYAN R GALLAGHER, JAMES A VAN KAN, CHRISTA HALL, ANTHONY K OLSSON, BIRGITTA SIREAU, NICOLAS AYOOB, HANA , et al. TIMMIS, OLIVER G LE QUAN SANG, KIM-HANH GENOVESE, FEDERICA IMRICH, RICHARD ROVENSKY, JOZEF SRINIVASARAGHAVAN, RANGAN BHARADWAJ, SHRUTHI K SPIEGEL, RONEN ZATKOVA, ANDREA ; Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on -black bone disease? in Italy. European Journal of Human Genetics , v. 24, p. 66-72, 2015.

• FEIL, SUSANNE C. ; ASCHER, DAVID B. ; KUIPER, MICHAEL J. ; TWETEN, RODNEY K. ; PARKER, MICHAEL W. . Structural Studies of Streptococcus pyogenes Streptolysin O Provide Insights into the Early Steps of Membrane Penetration. Journal of Molecular Biology , v. 426, p. 785-792, 2014.

• CRESPI, GABRIELA A. N. ; ASCHER, DAVID B. ; PARKER, MICHAEL W. ; MILES, LUKE A. . Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-β. Acta Crystallographica Section F Structural Biology Communications , v. 70, p. 374-377, 2014.

• ASCHER, DAVID B. ; WIELENS, JEROME ; NERO, TRACY L. ; DOUGHTY, LARISSA ; MORTON, CRAIG J. ; PARKER, MICHAEL W. . Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. Scientific Reports , v. 4, p. 4765, 2014.

• WATT, ANDREW D. ; CRESPI, GABRIELA A. N. ; DOWN, RUSSELL A. ; ASCHER, DAVID B. ; GUNN, ADAM ; PEREZ, KEYLA A. ; MCLEAN, CATRIONA A. ; VILLEMAGNE, VICTOR L. ; PARKER, MICHAEL W. ; BARNHAM, KEVIN J. ; MILES, LUKE A. . Do current therapeutic anti-Aβ antibodies for Alzheimer?s disease engage the target?. Acta Neuropathologica , v. 127, p. 803-810, 2014.

• WATT, ANDREW D. ; CRESPI, GABRIELA A. N. ; DOWN, RUSSELL A. ; ASCHER, DAVID B. ; GUNN, ADAM ; PEREZ, KEYLA A. ; MCLEAN, CATRIONA A. ; VILLEMAGNE, VICTOR L. ; PARKER, MICHAEL W. ; BARNHAM, KEVIN J. ; MILES, LUKE A. . Anti-Aβ antibody target engagement: a response to Siemers et al.. Acta Neuropathologica , v. 128, p. 611-614, 2014.

• PIRES, D. E. V. ; BLUNDELL, T. L. ; ASCHER, D. B. . Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes. Nucleic Acids Research (Online) , v. 43, p. D387-D391, 2014.

• PIRES, D. E. V. ; ASCHER, D. B. ; BLUNDELL, T. L. . DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach. Nucleic Acids Research (Online) , v. 42, p. W314-W319, 2014.

• KAMINSKAS, LISA M. ; ASCHER, DAVID B. ; MCLEOD, VICTORIA M. ; HEROLD, MARCO J. ; LE, CAROLINE P. ; SLOAN, ERICA K. ; PORTER, CHRISTOPHER J.H. . PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases. Journal of Controlled Release , v. 168, p. 200-208, 2013.

• POLEKHINA, GALINA ; ASCHER, DAVID BENJAMIN ; KOK, SHIE FOONG ; BECKHAM, SIMONE ; WILCE, MATTHEW ; WALTHAM, MARK . Structure of the N-terminal domain of human thioredoxin-interacting protein. Acta Crystallographica Section D Biological Crystallography , v. 69, p. 333-344, 2013.

• PIRES, D. E. V. ; ASCHER, D. B. ; BLUNDELL, T. L. . mCSM: predicting the effects of mutations in proteins using graph-based signatures. Bioinformatics (Oxford. Print) , v. 30, p. 335-342, 2013.

• ASCHER, DAVID B. ; POLEKHINA, GALINA ; PARKER, MICHAEL W. . Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2. Acta Crystallographica. Section F , v. 68, p. 468-471, 2012.

• PARKER, LORIEN J. ; ASCHER, DAVID B. ; GAO, CHEN ; MILES, LUKE A. ; HARRIS, HUGH H. ; PARKER, MICHAEL W. . Structural approaches to probing metal interaction with proteins. Journal of Inorganic Biochemistry , v. 115, p. 138-147, 2012.

• MILES, LUKE ; CRESPI, GABRIELA ; ASCHER, DAVID ; NERO, TRACY ; PARKER, MICHAEL . Structural basis of immunotherapies targeting the beta-amyloid peptide. Alzheimer's & Dementia , v. 8, p. P641, 2012.

• GAO, CHEN ; CRESPI, GABRIELA ; ASCHER, DAVID ; MILES, LUKE ; PARKER, MICHAEL . Structural studies of Alzheimer's disease amyloid precursor protein. Alzheimer's & Dementia , v. 8, p. S760, 2012.

• ASCHER, DAVID B. ; CROMER, BRETT A. ; MORTON, CRAIG J. ; VOLITAKIS, IRENE ; CHERNY, ROBERT A. ; ALBISTON, ANTHONY L. ; CHAI, SIEW YEEN ; PARKER, MICHAEL W. . Regulation of Insulin-Regulated Membrane Aminopeptidase Activity by Its C-Terminal Domain. Biochemistry (Easton) , v. 50, p. 2611-2622, 2011.

• POLEKHINA, GALINA ; ASCHER, DAVID BENJAMIN ; KOK, SHIE FOONG ; WALTHAM, MARK . Crystallization and preliminary X-ray analysis of the N-terminal domain of human thioredoxin-interacting protein. Acta Crystallographica. Section F , v. 67, p. 613-617, 2011.

• PARKER, LORIEN J. ; ITALIANO, LOUIS C. ; MORTON, CRAIG J. ; HANCOCK, NANCY C. ; ASCHER, DAVID B. ; AITKEN, JADE B. ; HARRIS, HUGH H. ; CAMPOMANES, PABLO ; ROTHLISBERGER, URSULA ; DE'LUCA, ANASTASIA ; LO'BELLO, MARIO ; ANG, WEE HAN ; DYSON, PAUL J. ; PARKER, MICHAEL W. . Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation. Chemistry - A European Journal , v. 17, p. 7806-7816, 2011.

• 2008 MILES, LUKE A. ; CRESPI, GABRIELA A. N. ; WYCHERLEY, KAYE ; ASCHER, DAVID B. ; BARNHAM, KEVIN J. ; CAPPAI, ROBERTO ; BEYREUTHER, KONRAD ; MASTERS, COLIN L. ; PARKER, MICHAEL W. ; MCKINSTRY, WILLIAM J. . Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Aβ peptides associated with Alzheimer's disease. Acta Crystallographica. Section F , v. 64, p. 438-441, 2008.

• YE, SIYING ; CHAI, SIEW YEEN ; LEW, REBECCA A. ; ASCHER, DAVID B. ; MORTON, CRAIG J. ; PARKER, MICHAEL W. ; ALBISTON, ANTHONY L. . Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase. Biochemistry and Cell Biology (Print) , v. 86, p. 251-261, 2008.

• ALBISTON, A. L. ; MORTON, C. J. ; NG, H. L. ; PHAM, V. ; YEATMAN, H. R. ; YE, S. ; FERNANDO, R. N. ; DE BUNDEL, D. ; ASCHER, D. B. ; MENDELSOHN, F. A. O. ; PARKER, M. W. ; CHAI, S. Y. . Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. The FASEB Journal , v. 22, p. 4209-4217, 2008.

• CHAI, SIEW ; YEATMAN, HOLLY R ; PARKER, MICHAEL W ; ASCHER, DAVID B ; THOMPSON, PHILIP E ; MULVEY, HAYLEY T ; ALBISTON, ANTHONY L . Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase. BMC Neuroscience (Online) , v. 9, p. S14, 2008.

• Ascher, David B. ; CRESPI, GABRIELA A. N. ; NG, HOOI LING ; MORTON, CRAIG J. ; PARKER, MICHAEL W. ; MILES, LUKE A. . Novel Therapeutic Approaches to Treat Alzheimer?s Disease and Memory Disorders. Journal of Proteomics & Bioinformatics , v. 01, p. 464-476, 2008.

• Ascher, David B. ; Jubb, Harry C. ; PIRES, DOUGLAS E. V. ; Ochi, Takashi ; Higueruelo, Alicia ; BLUNDELL, TOM L. . Protein-Protein Interactions: Structures and Druggability. NATO Science for Peace and Security Series A: Chemistry and Biology. 1ed.: Springer Netherlands, 2015, v. , p. 141-163.

• Usher, Jeannette L. ; Ascher, David B. ; PIRES, DOUGLAS E. V. ; Milan, Anna M. ; BLUNDELL, TOM L. ; Ranganath, Lakshminarayan R. . Analysis of HGD Gene Mutations in Patients with Alkaptonuria from the United Kingdom: Identification of Novel Mutations. JIMD Reports. 1ed.: Springer Berlin Heidelberg, 2014, v. , p. 3-11.

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