Fernando Otaviano Campos

Pós-doutorado

Idiomas

Áreas de atuação

Participação em eventos

Produções bibliográficas

• Campos, Fernando O. ; BHAGIRATH, PRANAV ; MONACI, SOFIA ; CHEN, ZHONG ; WHITAKER, JOHN ; PLANK, GERNOT ; RINALDI, CHRISTOPHER ALDO ; BISHOP, MARTIN J. . Reconstructed scar morphology in patient-specific computational heart models has limited impact on the identification of ablation targets through in-silico pace mapping. COMPUTERS IN BIOLOGY AND MEDICINE , v. 191, p. 110229, 2025.

• BHAGIRATH, PRANAV ; Campos, Fernando O. ; ZAIDI, HASSAN A. ; CHEN, ZHONG ; ELLIOTT, MARK ; GOULD, JUSTIN ; KEMME, MICHIEL J.B. ; WILDE, ARTHUR A.M. ; GÖTTE, MARCO J.W. ; POSTEMA, PIETER ; PRASSL, ANTON J. ; NEIC, AUREL ; PLANK, GERNOT ; RINALDI, CHRISTOPHER A. ; BISHOP, MARTIN J. . Predicting postinfarct ventricular tachycardia by integrating cardiac MRI and advanced computational reentrant pathway analysis. HEART RHYTHM , v. InPres, p. In press, 2024.

• GIARDINI, FRANCESCO ; OLIANTI, CAMILLA ; ARECCHI, GIULIA ; Campos, Fernando O. ; ZAGLIA, TANIA ; MONGILLO, MARCO ; CHELKO, STEPHEN ; LOEW, LESLIE M. ; CERBAI, ELISABETTA ; ZGIERSKI-JOHNSTON, CALLUM M. ; KOHL, PETER ; BISHOP, MARTIN J. ; SACCONI, LEONARDO . Dissecting the role of structural remodeling on trans-scar conduction in arrhythmogenic mouse hearts by advanced optical methods. BIOPHYSICAL JOURNAL , v. 123, p. 435a, 2024.

• BHAGIRATH, P ; CAMPOS, F O ; HOPMAN, L ; KEMME, M J B ; POSTEMA, P G ; PRASSL, A J ; NEIC, A ; ROBBERS, L F H J ; GOTTE, M J W ; PLANK, G ; VAN HALM, V P ; BISHOP, M . Impact of phase-correction of late-gadolinium enhancement images on quantification of scar metrics and in-silico VT-modelling in patients with an ischemic cardiomyopathy. EUROPACE , v. 26, p. euae102.309, 2024.

• BURGER, JANNEKE C. ; HOPMAN, LUUK H.G.A. ; KEMME, MICHIEL J.B. ; HOEKSEMA, WIERT ; TAKX, RICHARD A.P. ; FIGUERAS I VENTURA, ROSA M. ; Campos, Fernando O. ; Plank, Gernot ; PLANKEN, R. NILS ; ALLAART, CORNELIS P. ; VAN HALM, VOKKO P. ; POSTEMA, PIETER G. ; GÖTTE, MARCO J.W. ; BISHOP, MARTIN J. ; BHAGIRATH, PRANAV . Optimizing ventricular tachycardia ablation through imaging-based assessment of arrhythmic substrate: A comprehensive review and roadmap for the future. Heart Rhythm O2 , v. 5, p. 561-572, 2024.

• Campos, Fernando O. ; WIJESURIYA, NADEEV ; ELLIOTT, MARK K. ; DE VERE, FELICITY ; HOWELL, SANDRA ; STROCCHI, MARINA ; MONACI, SOFIA ; WHITAKER, JOHN ; Plank, Gernot ; RINALDI, CHRISTOPHER A. ; BISHOP, MARTIN J. . In silico pace mapping identifies pacing sites more accurately than inverse body surface potential mapping. HEART RHYTHM , v. Vol0, p. Pg0, 2024.

• BHAGIRATH, PRANAV ; CAMPOS, FERNANDO O ; POSTEMA, PIETER G ; KEMME, MICHIEL J B ; WILDE, ARTHUR A M ; PRASSL, ANTON J ; NEIC, AUREL ; RINALDI, CHRISTOPHER A ; GÖTTE, MARCO J W ; Plank, Gernot ; BISHOP, MARTIN J . Arrhythmogenic vulnerability of re-entrant pathways in post-infarct ventricular tachycardia assessed by advanced computational modelling. EUROPACE , v. 25, p. 1, 2023.

• QIAN, SHUANG ; MONACI, SOFIA ; MENDONCA-COSTA, CAROLINE ; Campos, Fernando ; GEMMELL, PHILIP ; ZAIDI, HASSAN A ; RAJANI, RONAK ; WHITAKER, JOHN ; RINALDI, CHRISTOPHER A ; BISHOP, MARTIN J . Additional coils mitigate elevated defibrillation threshold in right-sided implantable cardioverter defibrillator generator placement: a simulation study. EUROPACE , v. 25, p. 1, 2023.

• Campos, Fernando O. ; SHIFERAW, YOHANNES ; WHITAKER, JOHN ; Plank, Gernot ; BISHOP, MARTIN J. . Subthreshold delayed afterdepolarizations provide an important arrhythmogenic substrate in the border zone of infarcted hearts. HEART RHYTHM , v. 20, p. 299-306, 2023.

• QIAN, SHUANG ; CONNOLLY, ADAM ; MENDONCA-COSTA, CAROLINE ; Campos, Fernando ; RODERO, CRISTOBAL ; WHITAKER, JOHN ; RINALDI, CHRISTOPHER A ; BISHOP, MARTIN J . Optimization of anti-tachycardia pacing efficacy through scar-specific delivery and minimization of re-initiation: a virtual study on a cohort of infarcted porcine hearts. EUROPACE , v. 25, p. 716-725, 2023.

• Campos, Fernando O. ; NEIC, AUREL ; MENDONCA COSTA, CAROLINE ; WHITAKER, JOHN ; O?NEILL, MARK ; RAZAVI, REZA ; RINALDI, CHRISTOPHER A. ; DANIELSCHERR ; NIEDERER, STEVEN A. ; Plank, Gernot ; BISHOP, MARTIN J. . An automated near-real time computational method for induction and treatment of scar-related ventricular tachycardias. MEDICAL IMAGE ANALYSIS , v. 80, p. 102483, 2022.

• BHAGIRATH, PRANAV ; Campos, Fernando O. ; COSTA, CAROLINE M. ; WILDE, ARTHUR A.M. ; PRASSL, ANTON J. ; NEIC, AUREL ; Plank, Gernot ; RINALDI, CHRISTOPHER A. ; GÖTTE, MARCO J.W. ; BISHOP, MARTIN J. . Predicting arrhythmia recurrence following catheter ablation for ventricular tachycardia using late gadolinium enhancement magnetic resonance imaging: Implications of varying scar ranges. HEART RHYTHM , v. 19, p. 1604-1610, 2022.

• MENDONCA COSTA, CAROLINE ; GEMMELL, PHILIP ; ELLIOTT, MARK K. ; WHITAKER, JOHN ; Campos, Fernando O. ; STROCCHI, MARINA ; NEIC, AUREL ; GILLETTE, KARLI ; VIGMOND, EDWARD ; Plank, Gernot ; RAZAVI, REZA ; O'NEILL, MARK ; RINALDI, CHRISTOPHER A. ; BISHOP, MARTIN J. . Determining anatomical and electrophysiological detail requirements for computational ventricular models of porcine myocardial infarction. COMPUTERS IN BIOLOGY AND MEDICINE , v. 141, p. 105061, 2022.

• Campos, Fernando O. ; ORINI, MICHELE ; ARNOLD, ROBERT ; WHITAKER, JOHN ; O?NEILL, MARK ; RAZAVI, REZA ; Plank, Gernot ; HANSON, BEN ; PORTER, BRADLEY ; RINALDI, CHRISTOPHER ALDO ; GILL, JASWINDER ; LAMBIASE, PIER D. ; TAGGART, PETER ; BISHOP, MARTIN J. . Assessing the ability of substrate mapping techniques to guide ventricular tachycardia ablation using computational modelling. COMPUTERS IN BIOLOGY AND MEDICINE , v. x, p. 104214, 2021.

• QIAN, SHUANG ; CONNOLLY, ADAM ; MENDONCA-COSTA, CAROLINE ; Campos, Fernando ; WILLIAMS, STEVEN E. ; WHITAKER, JOHN ; RINALDI, CHRISTOPHER A. ; BISHOP, MARTIN J. . An in-silico assessment of efficacy of two novel intra-cardiac electrode configurations versus traditional anti-tachycardia pacing therapy for terminating sustained ventricular tachycardia. COMPUTERS IN BIOLOGY AND MEDICINE , v. 139, p. 104987, 2021.

• ORINI, MICHELE ; GRAHAM, ADAM J. ; SRINIVASAN, NEIL T. ; Campos, Fernando O. ; HANSON, BEN M. ; CHOW, ANTHONY ; HUNTER, ROSS J. ; SCHILLING, RICHARD J. ; FINLAY, MALCOLM ; EARLEY, MARK J. ; SPORTON, SIMON ; DHINOJA, MEHUL ; LOWE, MARTIN ; PORTER, BRADLEY ; CHILD, NICHOLAS ; RINALDI, CHRISTOPHER A. ; GILL, JASWINDER ; BISHOP, MARTIN ; TAGGART, PETER ; LAMBIASE, PIER D. ; et.al . Evaluation of the reentry vulnerability index to predict ventricular tachycardia circuits using high-density contact mapping. HEART RHYTHM , v. 17, p. 576-583, 2020.

• GOULD, JUSTIN ; PORTER, BRADLEY ; SIDHU, BALDEEP S ; CLARIDGE, SIMON ; CHEN, ZHONG ; SIENIEWICZ, BENJAMIN J ; ELLIOTT, MARK ; MEHTA, VISHAL ; CAMPOS, FERNANDO O ; BISHOP, MARTIN J ; COSTA, CAROLINE MENDONCA ; NIEDERER, STEVEN ; GANESHAN, BALAJI ; RAZAVI, REZA ; CHIRIBIRI, AMEDEO ; RINALDI, CHRISTOPHER A . High mean entropy calculated from cardiac MRI texture analysis is associated with anti-tachycardia pacing failure. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY , v. x, p. pace.13969, 2020.

• Campos, Fernando O. ; ORINI, MICHELE ; TAGGART, PETER ; HANSON, BEN ; LAMBIASE, PIER D. ; PORTER, BRADLEY ; RINALDI, CHRISTOPHER ALDO ; GILL, JASWINDER ; BISHOP, MARTIN J. . Characterizing the clinical implementation of a novel activation-repolarization metric to identify targets for catheter ablation of ventricular tachycardias using computational models. COMPUTERS IN BIOLOGY AND MEDICINE , v. 108, p. 263-275, 2019.

• Campos, Fernando O. ; WHITAKER, JOHN ; NEJI, RADHOUENE ; ROUJOL, SÉBASTIEN ; O?NEILL, MARK ; Plank, Gernot ; BISHOP, MARTIN J. . Factors Promoting Conduction Slowing as Substrates for Block and Reentry in Infarcted Hearts. BIOPHYSICAL JOURNAL , v. 117, p. 2361-2374, 2019.

• Campos, Fernando O. ; SHIFERAW, YOHANNES ; Weber dos Santos, Rodrigo ; Plank, Gernot ; BISHOP, MARTIN J. . Microscopic Isthmuses and Fibrosis Within the Border Zone of Infarcted Hearts Promote Calcium-Mediated Ectopy and Conduction Block. Frontiers in Physics , v. 6, p. 57, 2018.

• OLIVEIRA, Rafael Sachetto ; ALONSO, SERGIO ; Campos, Fernando Otaviano ; ROCHA, BERNARDO MARTINS ; FERNANDES, JOÃO FILIPE ; KUEHNE, TITUS ; DOS SANTOS, RODRIGO WEBER . Ectopic beats arise from micro-reentries near infarct regions in simulations of a patient-specific heart model. Scientific Reports , v. 8, p. 1, 2018.

• CONNOLLY, ADAM ; KELLY, ALLEN ; Campos, Fernando O. ; MYLES, RACHEL ; SMITH, GODFREY ; BISHOP, MARTIN J. . Ventricular Endocardial Tissue Geometry Affects Stimulus Threshold and Effective Refractory Period. BIOPHYSICAL JOURNAL , v. 115, p. 2486-2498, 2018.

• OLIVEIRA, Rafael Sachetto ; ALONSO, SERGIO ; Fernando Otaviano Campos ; ROCHA, Bernardo Martins ; FERNANDES, JOÃO FILIPE ; KUEHNE, TITUS ; SANTOS, Rodrigo Weber dos . Ectopic beats arise from micro-reentries near infarct regions in simulations of a patient-specific heart model. Scientific Reports , v. 8, p. 1-14, 2018.

• Campos, Fernando O. ; SHIFERAW, YOHANNES ; VIGMOND, EDWARD J. ; Plank, Gernot . Stochastic spontaneous calcium release events and sodium channelopathies promote ventricular arrhythmias. CHAOS , v. 27, p. 093910, 2017.

• NEIC, AUREL ; Campos, Fernando O. ; PRASSL, ANTON J. ; NIEDERER, STEVEN A. ; BISHOP, MARTIN J. ; VIGMOND, EDWARD J. ; Plank, Gernot . Efficient computation of electrograms and ECGs in human whole heart simulations using a reaction-eikonal model. JOURNAL OF COMPUTATIONAL PHYSICS , v. 346, p. 191-211, 2017.

• AUGUSTIN CM ; CROZIER A ; NEIC A ; PRASSL AJ ; KARABELAS E ; Ferreira da Silva T ; FERNANDES JF ; CAMPOS, F O ; KUEHNE T ; Plank G . Patient-specific modeling of left ventricular electromechanics as a driver for haemodynamic analysis. EUROPACE , v. 18, p. iv121-iv129, 2016.

• Campos, F. O. ; SHIFERAW, Y. ; PRASSL, A. J. ; BOYLE, P. M. ; VIGMOND, E. J. ; PLANK, G. . Stochastic Spontaneous Calcium Release Events Trigger Premature Ventricular Complexes by Overcoming Electrotonic Load. Cardiovascular Research , v. 107, p. 175-83, 2015.

• Costa, C.M. ; Fernando Otaviano Campos ; Prassl, A. ; SANTOS, Rodrigo Weber dos ; SANCHEZ-QUINTANA, DAMIAN ; Ahammer, H. ; HOFER, Ernst ; Plank, Gernot . An Efficient Finite Element Approach for Modeling Fibrotic Clefts in the Heart. IEEE Transactions on Biomedical Engineering (Print) , v. 61, p. 900-910, 2014.

• CAMPOS, RICARDO SILVA ; Campos, Fernando Otaviano ; GOMES, JOHNNY MOREIRA ; BARROS BARBOSA, CIRO ; LOBOSCO, MARCELO ; SANTOS, RODRIGO WEBER . Comparing high performance techniques for the automatic generation of efficient solvers of cardiac cell models. Computing (Wien. Print) , v. 2013, p. 1-22, 2013.

• Campos, Fernando ; WIENER, THOMAS ; PRASSL, ANTON ; Weber dos Santos, Rodrigo ; SANCHEZ-QUINTANA, DAMIAN ; AHAMMER, HELMUT ; PLANK, GERNOT ; HOFER, ERNST . Electro-Anatomical Characterization of Atrial Microfibrosis in a Histologically Detailed Computer Model. IEEE Transactions on Biomedical Engineering (Print) , v. PP, p. 1-1, 2013.

• Giles, W. R. ; Campos, F. O. ; DAVENPORT, M. H. ; Weber dos Santos, R. ; Nygren, A. . High Heart Rate in Pregnancy is Modulated by Augmented Expression of an Ion Channel, If, in Pacemaker Tissue. Circulation (New York, N.Y.) , v. 2013, p. 1, 2013.

• Campos, Fernando O. ; PRASSL, ANTON J. ; SEEMANN, GUNNAR ; Weber dos Santos, Rodrigo ; PLANK, GERNOT ; HOFER, ERNST . Influence of ischemic core muscle fibers on surface depolarization potentials in superfused cardiac tissue preparations: a simulation study. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING , v. 50, p. 461-472, 2012.

• WIENER, T. ; Campos, F. O. ; PLANK, G. ; HOFER, E. . Decomposition of fractionated local electrograms using an analytic signal model based on sigmoid functions. Biomedizinische Technik/Biomedical Engineering , v. 57, p. 371-382, 2012.

• Rocha, B. M. ; Campos, Fernando ; AMORIM, R. M. ; PLANK, G. ; Santos, R. W. dos ; Liebmann, M. ; Haase, G. . Accelerating cardiac excitation spread simulations using graphics processing units. Concurrency and Computation , v. 23, p. 708-720, 2011.

• Weber dos Santos, R. ; Nygren, A. ; Campos, Fernando ; KOCH, H. ; Giles, W. R. . Experimental and theoretical ventricular electrograms and their relation to electrophysiological gradients in the adult rat heart. American Journal of Physiology. Heart and Circulatory Physiology , v. 297, p. H1521-H1534, 2009.

• DOS SANTOS, RODRIGO WEBER ; Campos, Fernando ; NEUMANN CIUFFO, LEANDRO ; NYGREN, ANDERS ; GILES, WAYNE ; KOCH, HANS . ATX-II Effects on the Apparent Location of M Cells in a Computational Model of a Human Left Ventricular Wedge. Journal of Cardiovascular Electrophysiology (Print) , v. 17, p. S86-S95, 2006.

• SANTO, D. P. M. E. ; LEITE, S. C. ; Novaes, G. M. ; Campos, F. O. ; BONDARENKO, V. E. . Simulations of Spontaneous Action Potentials via the Combination of β 1-Adrenergic Stimulation and NCX Mutation in Cardiac Myocytes of Mouse Left Ventricle. In: VI Latin American Congress on Biomedical Engineering CLAIB 2014, 2014, Paraná. IFMBE Proceedings, 2014. v. 49. p. 663-666.

• Campos, F. O. ; SHIFERAW, Y. ; PLANK, G. . Tissue Structure and Ca2+-Mediated Ectopic Beats. In: BMT 2013 - Biomedical Engineering Conference, 2013, Graz. Biomedical Engineering / Biomedizinische Technik, 2013. v. 58.

• OLIVEIRA, R. S. ; Rocha, B.M. ; AMORIM, R. M. ; Campos, F. O. ; Meira Junior, Wagner ; Toledo, Elson ; Weber dos Santos, Rodrigo . Comparing CUDA, OpenCL and OpenGL Implementations of the Cardiac Monodomain Equations. In: Parallel Processing and Applied Mathematics - PPAM, 2011, Torun. Lecture Notes in Computer Science, 2011. v. 7204. p. 111-120.

• COSTA, CAROLINE MENDONCA ; Campos, Fernando O. ; PRASSL, ANTON J. ; DOS SANTOS, RODRIGO WEBER ; SANCHEZ-QUINTANA, DAMIAN ; HOFER, ERNST ; PLANK, GERNOT . A finite element approach for modeling micro-structural discontinuities in the heart. In: 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011, Boston. 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011. p. 437.

• CAMPOS, F O ; WIENER, T ; PRASSL, A J ; AHAMMER, H ; PLANK, G ; Weber dos Santos, Rodrigo ; SANCHEZ-QUINTANA, D ; HOFER, E . A 2D-computer model of atrial tissue based on histographs describes the electro-anatomical impact of microstructure on endocardiac potentials and electric near-fields. In: 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010), 2010, Buenos Aires. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, 2010. p. 2541.

• AMORIM, R M ; ROCHA, B M ; CAMPOS, F O ; DOS SANTOS, RODRIGO W . Automatic code generation for solvers of cardiac cellular membrane dynamics in GPUs. In: 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010), 2010, Buenos Aires. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, 2010. p. 2666.

• Campos, F. O. ; dos Santos, R. W. ; Nygren, A. ; Giles, W. R. . Modeling the Action Potential in Mouse Sinoatrial Node Myocytes. In: World Congress on Medical Physics and Biomedical Engineering, 2010, Munich. IFMBE Proceedings, 2010. v. 25/4. p. 2211-2214.

• Campos, F. O. ; CAMPOS, R.S. ; dos Santos, R. W. . Evaluation of numerical methods and computational techniques for solving cardiac cell models. In: World Congress on Medical Physics and Biomedical Engineering, 2010, Munich. IFMBE Proceedings, 2010. v. 25/4. p. 2287-2290.

• Campos, F. O. ; PRASSL, A. J. ; PLANK, G. ; HOFER, E. . The contribution of core muscle fibers to the surface depolarization signals on cable-like cardiac tissue preparations - a computer simulation study. In: World Congress on Medical Physics and Biomedical Engineering, 2010, Munich. IFMBE Proceedings, 2010. v. 25/4. p. 2077-2080.

• HOFER, Ernst ; WIENER, T. ; Campos, F. O. ; SANCHEZ-QUINTANA, D. ; CLIMENT, V. ; Prassl, A. ; Plank, Gernot . Heterogeneity of micro- and macro-conduction in atrial pectinate muscles studied with cardiac near field measurements and computer simulation. In: World Congress on Medical Physics and Biomedical Engineering, 2010, Munich. IFMBE Proceedings, 2009. v. 25/2. p. 559-562.

• Rocha, B.M. ; Campos, F. O. ; PLANK, G. ; dos Santos, R. W. ; LIEBMANN, M. ; HAASE, G. . Simulations of the Electrical Activity in the Heart with Graphic Processing Units. In: Parallel Processing and Applied Mathematics (PPAM), 2010, Wroclaw. Lecture Notes in Computer Science, 2009. v. 6067. p. 439-448.

• HOFER, E. ; WIENER, T. ; Campos, F. O. ; PRASSL, A.J. ; SANCHEZ-QUINTANA, D. ; CLIMENT, V. ; PLANK, GERNOT . Macroconduction and microconduction during rapid pacing measured with cardiac near field technique. In: 4th European Conference of the International Federation for Medical and Biological Engineering, 2009, Antwerp. IFMBE Proceedings, 2008. v. 22. p. 1184-1187.

• COSTA, C. M. ; Campos, Ricardo Silva ; Campos, F. O. ; SANTOS, Rodrigo Weber dos . Web applications supporting the development of models of chagas? disease for left ventricular myocytes of adult rats. In: Computational Science - ICCS, 2008, Kraków. Lecture Notes in Computer Science. v. 5103. p. 120-129.

• Costa, Caroline Mendonça ; Campos, Ricardo Silva ; Campos, Fernando Otaviano ; Weber dos Santos, Rodrigo . Web Applications Supporting the Development of Models of Chagas? Disease for Left Ventricular Myocytes of Adult Rats. In: Computational Science - ICCS 2008, 2008, Kraków. Computational Science -- ICCS 2008: 8th International Conference, Krakow, Poland, June 23-25, 2008, Proceedings, Part III. Heidelberg: Springer Berlin Heidelberg, 2008. v. 5103. p. 120-129.

• MARTINS, D. M. S. ; Campos, F. O. ; CIUFFO, L. N. ; OLIVEIRA, R. S. ; AMORIM, R. M. ; VIEIRA, V.F. ; EBECKEN, N. F. F. ; BARBOSA, C. B. ; Weber dos Santos, R. . A Computational Framework for Cardiac Modeling Based on Distributed Computing and Web Applications. In: High Performance Computing for Computational Science - VECPAR, 2007, Rio de Janeiro. Lecture Notes in Computer Science, 2006. v. 4395. p. 544-555.

• Campos, F. O. ; OLIVEIRA, R. S. ; dos Santos, R. W. . Performance comparison of parallel geometric and algebraic multigrid preconditioners for the bidomain equations. In: Computational Science - ICCS, 2006, Reading. Lecture Notes in Computer Science, 2006. v. 3991. p. 76-83.

• BARBOSA, C. B. ; dos Santos, R. W. ; AMORIM, R. M. ; CIUFFO, L. N. ; MANFROI, F. ; OLIVEIRA, R. S. ; Campos, F. O. . A transformation tool for ode based models. In: Computational Science - ICCS, 2006, Reading. Lecture Notes in Computer Science, 2006. v. 3991. p. 68-75.

• Campos, Fernando ; F. FERNANDES, JOAO ; SHIFERAW, YOHANNES ; KUEHNE, TITUS ; Weber dos Santos, Rodrigo ; BISHOP, MARTIN ; Plank, Gernot . A Multiscale Computational Model of Calcium-Mediated Ectopy in the Human Postinfarction Heart. In: 2018 Computing in Cardiology Conference, 2018.

• Campos, Fernando ; ORINI, MICHELE ; HANSON, BEN ; TAGGART, PETER ; LAMBIASE, PIER ; PORTER, BRADLEY ; ALDO RINALDI, CHRISTOPHER ; GILL, JASWINDER ; BISHOP, MARTIN . Optimization of a Novel Activation-Repolarization Metric to Identify Targets for Catheter Ablation. In: 2018 Computing in Cardiology Conference, 2018.

• ORINI, MICHELE ; HANSON, BEN ; TAGGART, PETER ; Campos, Fernando ; RINALDI, ALDO ; GILL, JASWINDER ; BISHOP, MARTIN ; LAMBIASE, PIER . Sequential Electro-Anatomical Mapping Methodology and Preliminary Results for Reentry Vulnerability Index Estimation. In: 2018 Computing in Cardiology Conference, 2018.

Projetos de pesquisa

• 2016 - 2017

  Mechanisms of Arrhythmias Induced by Calcium-mediated Ectopic Beats in Post-infarction Hearts, Descrição: Cardiovascular diseases (CVDs) continue to be the leading cause of morbidity and sudden death in adults, exceeding the mortality associated with breast, lung, and colon-rectum cancers combined. Studies indicated that the majority of sudden cardiac deaths are attributed to ventricular tachycardia or fibrillation. The mechanisms governing the initiation and persistence of such cardiac arrhythmias are highly complex. They involve interactions across multiple scales ranging from genes to the whole organ. Therefore, there is a compelling need for novel technologies to bridge the gaps between scales and provide insights into underlying mechanisms and potential targets to treat CVDs. Over the past years, computer modeling and simulation of cardiac electrophysiology has emerged as a powerful platform for the investigation of arrhythmias. Computer models provide a framework for the unification of diverse experimental findings in different scales. The goal of this project is to use multi-scale computer models to investigate the origin of scar-related arrhythmias induced by calcium-mediated ectopic beats. To achieve this goal we make use of a state-of-the-art modeling framework to build high resolution computer models based on the advanced medical imaging techniques available at the German Heart Institute Berlin.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Fernando Otaviano Campos - Integrante / Titus Kuehne - Coordenador.

• 2011 - 2015

  Calcium-mediated Ectopic Excitations in Cardiac Tissue, Descrição: Cardiac arrhythmias are responsible for more than 300,000 deaths per year in the US alone. Despite extensive research over many decades the underlying mechanisms for these arrhythmias are not completely understood. A common mechanism, believed to underlie a variety of arrhythmias, is the presence of ectopic focal excitations in the heart. These ectopic foci disrupt the normal sinus rhythm, and can produce triggered excitations which can lead to reentry and/or wave fractionation in the heart. Remarkably, it is not understood what determines the timing, location and morphology of these focal excitations. Many experimental studies have shown that abnormal calcium (Ca) cycling, at the single cell level, plays an essential role in the formation of these focal excitations. However, the detailed mechanisms linking subcellular Ca and focal excitations at the tissue and whole heart level is not known. The underlying mechanisms for ectopic foci are difficult to understand because of the vast length and time scales involved. Therefore, novel approaches are needed to bridge the range of scales involved in the problem. In this project we propose to develop a multi-scale computational framework that can be used to describe the properties of Ca mediated ectopic foci. Our aim is to explore how abnormal Ca cycling at the subcellular level can summate over thousands of cells to form ectopic foci in tissue. Our computer models will shed light on the underlying mechanisms by bridging the gap between ion channels, cell electrophysiology, and tissue scale electrical activity.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Fernando Otaviano Campos - Integrante / Gernot P - Coordenador / Yohannes Shiferaw - Integrante.

• 2008 - 2011

  Cardiac Conduction in the Right Atrial Isthmus, Descrição: Severe atrial conduction disturbances, namely atrial flutter and atrial fibrillation are associated with aging. Research on atrial conduction comprising functional and structural aspects associated aging is therefore of particular interest. The lateral and posterior part of the lower right atrium is seen as critical substrate for the genesis of intermittent block of conduction. Recent studies on the tissue matrix in several regions of the atria suggest, that excitation spread at a sub-millimetre size scale may differ substantially from activation maps taken from clinical recordings at a coarser size scale. However, clinical mapping systems capable of resolving activation sequences at this size scale will not be available in the foreseeable future. The aim of this project is to study and compare mechanisms of macro- and micro-propagation in the atrial isthmus by means of a structure-related computer model with high spatio-temporal resolutions. Tuning of the virtual tissue model is made by electrophysiological experiments. The results should push forward the knowledge of microstructure related conduction disturbances. A profound analysis of the signature of microstructure on signals measured in the extracellular space will open new aspects of diagnostic tools of arrhythmia analysis for future minimal-invasive catheter techniques.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (3) . , Integrantes: Fernando Otaviano Campos - Integrante / DOS SANTOS, RODRIGO WEBER - Integrante / Anton Prassl - Integrante / Gernot Plank - Integrante / Ernst Hofer - Coordenador / D. Sanchez-Quintana - Integrante / Helmut Ahammer - Integrante.

• 2006 - 2008

  Modelagem computacional das alterações eletrofisiológicas em miocárdio ventricular de ratos durante a doença de chagas, Descrição: O objetivo deste projeto é a construção de modelos computacionais que capturem as alterações eletrofisiológicas observadas em experimentos com miocárdio ventricular de ratos chagásicos. Especificamente, serão desenvolvidos modelos adimensionais para a célula do miocárdio ventricular e modelos bidimensionais para a propagação elétrica na parede ventricular esquerda de ratos. Os modelos celulares serão baseado em dados experimentais que caracterizam o potencial de ação, a dinâmica da concentração intracelular de Cálcio e diversas correntes iônicas, como as correntes de potássio IK, as correntes de sódio INa e as correntes de Cálcio, ICaL. Dados de experimentos realizados com corações isolados serão usados para desenvolver modelos da parede ventricular esquerda de ratos infectados.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Mestrado acadêmico: (1) . , Integrantes: Fernando Otaviano Campos - Integrante / Rodrigo Weber dos Santos - Coordenador / Jader dos Santos Cruz - Integrante., Financiador(es): Fundação de Amparo à Pesquisa do Estado de Minas Gerais - Auxílio financeiro.

• 2004 - 2006

  PARAFISIO: Computação Paralela, Metalinguagem XML e Servidor Web: Soluções para a neurofisiologia e a eletro-fisiologia cardíaca computacionais., Descrição: Este projeto tem como objetivo o emprego de tecnologias inovadoras para promover o desenvolvimento da área de neurofisiologia e a eletro-fisiologia cardíaca computacionais no Brasil. Técnicas de computação paralela de alto desempenho e a tecnologia de metalinguagem XML serão empregadas para acelerar e aumentar a produtividade do pequeno grupo de pesquisa deste projeto. Um potal Web baseado em técnicas para servidor Web permitirá a divulgação e utilização desta tecnologia de simulação computacional no Brasil, entre os diversos centros de pesquisa que trabalham nas áreas correlatas, visando o aprimoramento e a aceleração dos processos envolvidos no desenvolvimento de novos medicamentos e equipamentos médicos destinados ao tratamento/diagnóstico de enfermidades que acometem grande parte da população brasileira, como a doença de chagas, as arritmias cardíacas e a epilepsia.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (3) / Mestrado acadêmico: (2) . , Integrantes: Fernando Otaviano Campos - Integrante / Leandro Neumann Ciuffo - Integrante / Ronan Mendonça Amorim - Integrante / Ciro de Barros Barbosa - Integrante / Rodrigo Weber dos Santos - Coordenador / Rafael Sachetto - Integrante / Antônio Carlos Guimarães de Almeida - Integrante / Hewerson Zansávio Teixeira - Integrante., Financiador(es): Conselho Nacional de Desenvolvimento Científico e Tecnológico - Auxílio financeiro., Número de produções C, T & A: 1

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