Rogério Moraes de Castilho

Possui graduação em Odontologia pela Pontifícia Universidade Católica de Campinas (1995), mestrado e doutorado em Odontologia (Patologia Bucal) pela Universidade de São Paulo (2003), e pos-doutorado no National Institute of Dental and Craniofacial Research no National Institutes of Health, Bethesda, Maryland, USA (2009). Atualmente faz parte do corpo docente da Universidade de Michigan, Faculdade de Odontologia, Departamento de Periodontia e Medicina Oral. Tem experiência na área de patologia bucal, biologia celular e molecular e em modelos animais transgenicos, knockout e knockout condicionais. Atua nas areas de Carcinomas epidermoides de cabeca e pescoco, tumores das glandulas salivares, e na biologia do epitelio de revestimento incluindo a pele e a mucosa bucal.

Informações coletadas do Lattes em 18/05/2026

Acadêmico

Formação acadêmica

Doutorado em Odontologia (Patologia Bucal)

2001 - 2003

Universidade de São Paulo
Título: Transicao Epitelio-Mesenquimal em Carcinoams Epidermoides Bucais. Analise atravez da Expressao das Proteinas CTBP, Vimentina e B-Catenina e da Identificacao Genica de Larga Escala
Décio dos Santos Pinto. Bolsista do(a): Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, Brasil. Grande área: Ciências da SaúdeSetores de atividade: Cuidado À Saúde das Populações Humanas.

Mestrado em Odontologia (Patologia Bucal)

1999 - 2000

Universidade de São Paulo
Título: Análise da Expressão do CD44 e do Ácido Hialurônico em Adenomas Pleomórficos de Glândula Salivar, Ano de Obtenção: 2001
Marcia Martins Marques Jaeger.Bolsista do(a): Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, Brasil. Palavras-chave: Dissertação de Mestrado.Grande área: Ciências da SaúdeSetores de atividade: Cuidado À Saúde das Populações Humanas.

Especialização em Patoogia Bucal

1999 - 1999

C E O Sao Leopoldo Mandic
Título: Síndrome de Papillon Lefèvre
Orientador: Márcia Martins Marques

Graduação em Odontologia

1992 - 1995

Pontifícia Universidade Católica de Campinas, PUC Campinas

Ensino Médio (2º grau)

1988 - 1992

Colégio Objetivo de Campinas

Ensino Fundamental (1º grau)

1979 - 1987

Escola Comunitária de Campinas

Pós-doutorado

2004 - 2010

Pós-Doutorado. , National Institute Of Health, NIH, Estados Unidos. , Grande área: Ciências da Saúde, Grande Área: Ciências da Saúde / Área: Odontologia / Subárea: Estomatologia / Especialidade: Patologia Bucal.

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Italiano

Compreende Razoavelmente, Fala Pouco, Lê Razoavelmente, Escreve Pouco.

Francês

Compreende Pouco, Fala Pouco, Lê Pouco, Escreve Pouco.

Áreas de atuação

Grande área: Ciências da Saúde / Área: Odontologia / Subárea: Estomatologia/Especialidade: Patologia Bucal.

Grande área: Ciências Biológicas / Área: Biologia Geral.

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.

Grande área: Ciências da Saúde / Área: Medicina / Subárea: Dermatologia.

Participação em eventos

80 General Session and Exhibition of the IADR. Apresentação Internacional de Poster. 2002. (Congresso).

III Simpósio Temático sobre "Citoesqueleto e Diferenciação Celular".Curso Citoesqueleto e Diferenciação Celular. 2001. (Simpósio).

IX Congresso e XXVII Jornada Brasileira de Estomatologia. Participação como Congressista. 2001. (Congresso).

IX Congresso e XXVII Jornada Brasileira de Estomatologia. Curso Laser na Estomatologia. 2001. (Congresso).

IX Congresso e XXVII Jornada Brasileira de Estomatologia. Autor de Caso Clínico. 2001. (Congresso).

17 Reunião Anual SBPqO. Apresentação de poster. 2000. (Congresso).

Apoptosis in the Immune System.Curso Apoptosis in the Immune System. 2000. (Outra).

VII Reunião de Pesquisa V Seminário de Iniciação Científica da FOUSP.Apresentação de poster. 2000. (Seminário).

IV Congresso Brasileiro de Câncer Bucal. Curso Diagnóstico das Doenças da Boca. 1999. (Congresso).

IV Congresso Brasileiro de Câncer Bucal. Participação como Congressista no IV Congresso Brasileiro de Câncer Bucal. 1999. (Congresso).

IV Congresso Brasileiro de Câncer Bucal. Curso Patologia. 1999. (Congresso).

IV Congresso Brasileiro de Câncer Bucal Congresso Brasileiro de Câncer Bucal. Curso Tumores de Glândulas Salivares. 1999. (Congresso).

XIII JOPE Jornada Odontológica Brasileira de Estudos Sobre Pacientes Especiais.Autor de tema livrre 'Pacientes Transplantados Renais na Visão Odontológica: Relato de um Caso'. 1999. (Seminário).

XVII Congresso da Sociedade Brasileira de Microscopia e Microanálise. Participação como Congressista do XVII Congresso da Sociedade Brasileira de Microscopia e Microanálise. 1999. (Congresso).

XXV Jornada Brasileira de Estomatologia e VII Congresso Brasileiro de Estomatologia. Curso Internacional Cistos Odontogênicos e Curso Nacional Diagnóstico Bucal. 1999. (Congresso).

VI Reunião de Pesquisa III Seminário de Iniciação Científica.Curso Internacional de Matriz Extra-Celular. 1998. (Seminário).

VI Reunião de Pesquisa II Seminário de Iniciação Científica.Curso internacional de Periodontia. 1998. (Seminário).

12 Conclave Odontológico Internacional de Campinas. Curso Reabilitação Perio/Prótese/Implante. 1997. (Congresso).

12 Conclave Odontológico Internacional de Campinas. Regeneração Tecidual Guiada. 1997. (Congresso).

XII Conclave Odontológico Internacional de Campinas. Participação do XII Conclave Odontológico Internacional de Campinas. 1997. (Congresso).

17 Congresso Internacional de Odontologia de São Paulo. Participação como Congressista no Congresso Internacional de Odontologia da Associação Paulista dos Cirurgiões Dentistas. 1996. (Congresso).

1 Encontro de Ortodontia Preventiva e Interceptadora.Participação como Congressista. 1996. (Encontro).

20 Congresso Universitário Brasileiro de Odontologia. Curso Terapêutica para Pacientes com Doenças Sistêmicas. 1995. (Congresso).

20 Congresso Universitário Brasileiro de Odontologia. Curso Pacientes Especiais: HIV+, Distúrbios Neurológicos, Psicoses e Neuroses. 1995. (Congresso).

20 Congresso Universitário Brasileiro de Odontologia. Participação como Congressista no 20 Congresso Universitário Brasileiro de Odontologia. 1995. (Congresso).

20 Congresso Universitário Brasileiro de Odontologia. Curso Primeiros Socorros Aplicado à Odontologia. 1995. (Congresso).

XXXIX Semana Odontológica da PUCCAMP. Participação como Congressista da Semana Odontológica da Pontifícia Universidade Católica de Campinas. 1995. (Congresso).

I Simpósio Brasileiro de Informática em Odontologia e Medicina Bucal.Participação como Congressista. 1994. (Simpósio).

XXXVII Semana Odontológica.Participação como Congressita. 1993. (Encontro).

XXXVII Semana Odontológica.Curso Dentística. 1993. (Encontro).

XXXVI Semana Odontológica de Campinas.Participação como Congressista na XXXVI Semana Odontológica de Campinas. 1992. (Encontro).

Produções bibliográficas

SCHUCH, LAUREN FRENZEL ; CAMPAGNOL, DANIELA ; SCHMIDT, TUANY RAFAELI ; MICHEL, CAROLINA HORN TROIAN ; GARCEZ, TUANE NERISSA ALVES ; VELHO, VANESSA RODRIGUES ; WAGNER, VIVIAN PETERSEN ; CASTILHO, ROGERIO MORAES ; SILVEIRA, FELIPE MARTINS ; BOLOGNA-MOLINA, RONELL ; MARTINS, MARCO ANTONIO TREVIZANI ; DANILEVICZ, CHRIS KREBS ; SANTOS-SILVA, ALAN ROGER ; VARGAS, PABLO AGUSTIN ; MARTINS, MANOELA DOMINGUES . Investigating the safety of photobiomodulation in oral carcinogenesis: insights into cell proliferation, invasion, and apoptosis via the 4NQO model. Scientific Reports , v. 14, p. 28303, 2024.
DUBEY, NILESHKUMAR ; RAHIMNEJAD, MAEDEH ; SWANSON, W. BENTON ; XU, JINPING ; DE RUIJTER, MYLÈNE ; MALDA, JOS ; Squarize, Cristiane H. ; Castilho, Rogerio M. ; BOTTINO, MARCO C. . Integration of Melt Electrowritten Polymeric Scaffolds and Bioprinting for Epithelial Healing via Localized Periostin Delivery. ACS Macro Letters , v. 13, p. 959-965, 2024.
WARNER, KRISTY A. ; HERZOG, ALEXANDRA E. ; SAHARA, SOSUKE ; NÖR, FELIPE ; Castilho, Rogerio M. ; DEMIRCI, HAKAN ; CHEPEHA, DOUGLAS B. ; POLVERINI, PETER J. ; NÖR, JACQUES E. . Establishment and characterization of cMYB-expressing human salivary adenoid cystic carcinoma cell lines (UM-HACC-14, UM-HACC-6) and matching patient-derived xenograft model (UM-PDX-HACC-14). Oral Surgery Oral Medicine Oral Pathology Oral Radiology , v. 138, p. 516-531, 2024.
Castilho, Rogerio M. ; CASTILHO, LEONARD S. ; PALOMARES, BRUNA H. ; Squarize, Cristiane H. . Determinants of Chromatin Organization in Aging and Cancer-Emerging Opportunities for Epigenetic Therapies and AI Technology. Genes , v. 15, p. 710, 2024.
PINA, PAULO S. S. ; JANG, YEEJIN ; EMERICK, CAROLINA ; SCARINI, JOÃO FIGUEIRA ; SOUSA, SUZANA C. O. M. ; Squarize, Cristiane H. ; Castilho, Rogerio M. . Novel Epigenetic Modifiers of Histones Presenting Potent Inhibitory Effects on Adenoid Cystic Carcinoma Stemness and Invasive Properties. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 25, p. 1646, 2024.
DA SILVEIRA, ERICKA J. D. ; BARROS, CAIO C. D. S. ; BOTTINO, MARCO C. ; Castilho, Rogerio M. ; SQUARIZE, CRISTIANE . The rhythms of histones in regeneration: The epigenetic modifications determined by clock genes. EXPERIMENTAL DERMATOLOGY , v. 33, p. 15005, 2024.
YUJRA, VERONICA QUISPE ; SILVEIRA, ERICKA JANINE DANTAS DA ; RIBEIRO, DANIEL ARAKI ; CASTILHO, ROGERIO MORAES ; SQUARIZE, CRISTIANE HELENA . Clock genePer2modulates epidermal tissue repair in vivo. JOURNAL OF CELLULAR BIOCHEMISTRY , v. 125, p. 30513, 2024.
SILVA, LC. ; PÉREZ-DE-OLIVEIRA, ME. ; PEDROSO, CM. ; LEITE, AA. ; SANTOS-SILVA, AR. ; LOPES, MA. ; JUNIOR, GD. ; MARTINS, MD. ; WAGNER, VP. ; KOWALSKI, LP. ; SQUARIZE, LP. ; CASTILHO, RM. . Systemic therapies for salivary gland carcinomas: an overview of published clinical trials. Medicina Oral Patologia Oral y Cirugia Bucal , v. 29, p. e280-e287, 2024.
DE CASTRO, LETÍCIA RODRIGUES ; DE OLIVEIRA, LUCAS DIAS ; MILAN, THAÍS MORÉ ; ESKENAZI, ANA PATRÍCIA ESPALADORI ; BIGHETTI'TREVISAN, RAYANA LONGO ; DE ALMEIDA, OTÁVIO GUILHERME GONÇALVES ; AMORIM, MARCIO LUIS MUNHOZ ; SQUARIZE, CRISTIANE HELENA ; CASTILHO, ROGERIO MORAES ; DE ALMEIDA, LUCIANA OLIVEIRA . Up-regulation of TNF-alpha/NFkB/SIRT1 axis drives aggressiveness and cancer stem cells accumulation in chemoresistant oral squamous cell carcinoma. JOURNAL OF CELLULAR PHYSIOLOGY , v. 239, p. e31164, 2024.
ROLIM, LARISSA S A ; NASCENTE, PATRICIA DA S ; CASTILHO, ROGERIO M ; SQUARIZE, CRISTIANE H . Feeling the Heat. Mapping the Epigenetic Modifications of Histone during Burn Wound Healing. Journal of Burn Care & Research , v. 45, p. 499-507, 2024.
ALMEIDA, LUCIANA O. ; SILVA, LUAN CÉSAR ; EMERICK, CAROLINA ; AMORIM DOS SANTOS, JULIANA ; Castilho, Rogerio M. ; Squarize, Cristiane H. . Head and neck cancer stem cell maintenance relies on mTOR signaling, specifically involving the mechanistic target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2). ARCHIVES OF ORAL BIOLOGY , v. 157, p. 105840, 2024.
FERNANDES, DARCY ; BARBEIRO, CAMILA DE OLIVEIRA ; PALAÇON, MARIANA PARAVANI ; BIANCARDI, MARIEL RUIVO ; FERRISSE, TÚLIO MORANDIN ; SILVEIRA, HEITOR ALBERGONI ; CASTILHO, ROGERIO MORAES ; DE ALMEIDA, LUCIANA YAMAMOTO ; LEON, JORGE ESQUICHE ; BUFALINO, ANDREIA . High density of CD8 T cell and immune imbalance of T lymphocytes subsets are associated with proliferative verrucous leukoplakia. IMMUNOLOGY , v. 168, p. 96-109, 2023.
Castilho, Rogerio M. ; CASTILHO, MATTHEW S. ; SIMMONS, ZOË ; Squarize, Cristiane H. . Empowering the youth to choose non-traditional careers in research and academia. JOURNAL OF ORAL PATHOLOGY & MEDICINE , v. e, p. 1, 2023.
GUIMARAES, L. ; WEBBER, LIANA P ; GAIO, EDUARDO J. ; PINTO, DECIO S. ; GONCALVES, P. ; WICK, M. J. ; BURR, N. S. ; Squarize, C H ; Castilho, RM . Using PDX animal models to identify and stratify adenoid cystic carcinoma patients presenting an enhanced response to HDAC inhibitors. American Journal of Cancer Research , v. 13, p. 143-160, 2023.
COUTO, BÁRBARA ALEXANDRA DO AMARAL ; FERNANDES, JULIANA CAMPOS HASSE ; SAAVEDRA-SILVA, MARIANA ; ROCA, HERNAN ; CASTILHO, ROGÉRIO MORAES ; FERNANDES, GUSTAVO VICENTIS DE OLIVEIRA . Antisclerostin Effect on Osseointegration and Bone Remodeling. Journal of Clinical Medicine , v. 12, p. 1294, 2023.
SILVA, L. C. ; Amanda Almeida Leite ; BORGATO, GABRIELL BONIFACIO ; WAGNER, VIVIAN PETERSEN ; MARTINS, MANOELA DOMINGUES ; Felippe Jose Almeida Loureiro ; LOPES, MARCIO A. ; SANTOS-SILVA, ALAN ROGER ; SPERANDIO, M. ; Gilberto de Castro Junior ; Luiz Paulo Kowalski ; Cristiane H Squarize ; Castilho, Rogerio M. ; Pablo Agustin Vargas . Oral squamous cell carcinoma cancer stem cells have different drug sensitive to pharmacological NFκB and histone deacetylation inhibition. American Journal of Cancer Research , v. 13, p. 6038, 2023.
GARAICOA-PAZMINO, CARLOS ; COUSO-QUEIRUGA, EMILIO ; MONJE, ALBERTO ; AVILA-ORTIZ, GUSTAVO ; CASTILHO, ROGERIO ; AMO, FERNANDO . Disease resolution following treatment of peri-implant diseases: A systematic review. INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY , v. 11, p. 6935, 2023.
SCHUCH, LAUREN FRENZEL ; CAMPAGNOL, DANIELA ; SCHMIDT, TUANY RAFAELI ; MICHEL, CAROLINA HORN TROIAN ; GARCEZ, TUANE NERISSA ALVES ; DANILEVICZ, CHRIS KREBS ; CASTILHO, ROGERIO MORAES ; MARTINS, MARCO ANTONIO TREVIZANI ; VARGAS, PABLO AGUSTIN ; MARTINS, MANOELA DOMINGUES . Proposal of a secure and efficient protocol for a murine oral carcinogenesis model induced by 4-nitroquinoline-1-oxide (4NQO). PATHOLOGY RESEARCH AND PRACTICE , v. 247, p. 154547, 2023.
SILVA, LUAN CÉSAR ; BORGATO, GABRIELL BONIFACIO ; WAGNER, VIVIAN PETERSEN ; MARTINS, MANOELA DOMINGUES ; LOPES, MARCIO A. ; SANTOS-SILVA, ALAN ROGER ; Gilberto de Castro Junior ; KOWALSKI, LUIZ PAULO ; SQUARIZE, CRISTIANE H ; VARGAS, PABLO AGUSTIN ; Castilho, Rogerio M. . Repurposing NFκB and HDAC inhibitors to individually target cancer stem cells and non-cancer stem cells from mucoepidermoid carcinomas. American Journal of Cancer Research , v. 13, p. 1547, 2023.
BARBEIRO, CAMILA DE OLIVEIRA ; FERNANDES, DARCY ; PALAÇON, MARIANA PARAVANI ; CASTILHO, ROGERIO MORAES ; DE ALMEIDA, LUCIANA YAMAMOTO ; BUFALINO, ANDREIA . Inflammatory Cells Can Alter the Levels of H3K9ac and γH2AX in Dysplastic Cells and Favor Tumor Phenotype. Journal Of Personalized Medicine , v. 13, p. 662, 2023.
FERREIRA, LETÍCIA ANTUNES MUNIZ ; BEZERRA, MARIA ANTONIA DOS SANTOS ; KAWASAKI-OYAMA, ROSA SAYOKO ; FERNANDES, GLAUCIA MARIA DE MENDONÇA ; CASTANHOLE-NUNES, MÁRCIA MARIA URBANIN ; SERAFIM JUNIOR, VILSON ; CASTILHO, ROGÉRIO MORAES ; PAVARINO, ÉRIKA CRISTINA ; MANIGLIA, JOSÉ VICTOR ; GOLONI-BERTOLLO, ENY MARIA . Effect of ZEB1 Associated with microRNAs on Tumor Stem Cells in Head and Neck Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 24, p. 5916, 2023.
SILVA, L. C. ; BORGATO, GABRIELL BONIFACIO ; WAGNER, VIVIAN P ; MARTINS, MANOELA D. ; ROCHA, GUILHERME Z. ; LOPES, MARCIO A. ; SILVA, ALAN R. S. ; CASTRO JUNIOR, G. ; KOWALSKI, LUIZ PAULO ; NÖR, JACQUES E. ; Squarize, C H ; Castilho, RM . Cephaeline is an inductor of histone H3 acetylation and inhibitor of mucoepidermoid carcinoma cancer stem cells.. JOURNAL OF ORAL PATHOLOGY & MEDICINE (ONLINE) , v. 51, p. 553-562, 2022.
LARSSON, LENA ; GARAICOA'PAZMINO, CARLOS ; ASA'AD, FARAH ; CASTILHO, ROGERIO MORAES . Understanding the role of endotoxin tolerance in chronic inflammatory conditions and periodontal disease. JOURNAL OF CLINICAL PERIODONTOLOGY , v. 49, p. 270-279, 2022.
FERNANDES, GVO ; COSTA, BMGN ; TRINDADE, HF ; Castilho, RM ; FERNANDES, JCH . Comparative analysis between extra-short implants (≤6-mm) and 6-mm-longer implants: a meta-analysis of randomized controlled trial. AUSTRALIAN DENTAL JOURNAL , v. 67, p. 194-211, 2022.
MARQUES, ANA ELIZIA MASCARENHAS ; BORGES, GABRIEL ALVARES ; VIESI DO NASCIMENTO FILHO, CARLOS HENRIQUE ; VIANNA, LEONORA MACIEL DE SOUZA ; RAMOS, DORALINA DO AMARAL RABELLO ; CASTILHO, ROGERIO MORAES ; SQUARIZE, CRISTIANE HELENA ; GUERRA, ELIETE NEVES SILVA . Expression profile of the PI3K-AKT-mTOR pathway in head and neck squamous cell carcinoma: Data from Brazilian population. Oral Surgery Oral Medicine Oral Pathology Oral Radiology , v. 133, p. 453-461, 2022.
AMARAL-SILVA, GK. ; DIAS, LM. ; MARIZ, BA. ; FONSECA, FP. ; RANGEL, AL. ; ZANELLA, VG. ; CASTILHO, RM. ; MARTINS, MD. ; VARGAS, PA. ; WAGNER, VP. . MutSα expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical study. Medicina Oral Patologia Oral y Cirugia Bucal , v. 27, p. e164-e173, 2022.
NAAKKA, ERIKA ; BARROS-FILHO, MATEUS CAMARGO ; ADNAN-AWAD, SHADY ; AL-SAMADI, AHMED ; MARCHI, FÁBIO ALBUQUERQUE ; KUASNE, HELLEN ; KORELIN, KATJA ; SULEYMANOVA, ILIDA ; BROWN, AMY LOUISE ; SCAPULATEMPO-NETO, CRISTOVAM ; LOURENÇO, SILVIA VANESSA ; CASTILHO, ROGÉRIO MORAES ; KOWALSKI, LUIZ PAULO ; MÄKITIE, ANTTI ; ARAÚJO, VERA CAVALCANTI ; LEIVO, ILMO ; ROGATTO, SILVIA REGINA ; SALO, TUULA ; PASSADOR-SANTOS, FABRICIO . miR-22 and miR-205 Drive Tumor Aggressiveness of Mucoepidermoid Carcinomas of Salivary Glands. FRONTIERS IN ONCOLOGY , v. 11, p. 1-2, 2022.
TAVARES, LISANDRA TAÍSA REGINALDO ; SAAVEDRA-SILVA, MARIANA ; LÓPEZ-MARCOS, JOAQUÍN FRANCISCO ; VEIGA, NÉLIO JORGE ; CASTILHO, ROGERIO DE MORAES ; FERNANDES, GUSTAVO VICENTIS DE OLIVEIRA . Blood and Salivary Inflammatory Biomarkers Profile in Patients with Chronic Kidney Disease and Periodontal Disease: A Systematic Review. Diseases , v. 10, p. 12, 2022.
SIMÕES-PEDRO, MARA ; TRÓIA, PEDRO MARIA B. P. S. ; DOS SANTOS, NUNO BERNARDO MALTA ; COMPLETO, ANTÓNIO M. G. ; CASTILHO, ROGERIO MORAES ; DE OLIVEIRA FERNANDES, GUSTAVO VICENTIS . Tensile Strength Essay Comparing Three Different Platelet-Rich Fibrin Membranes (L-PRF, A-PRF, and A-PRF+): A Mechanical and Structural In Vitro Evaluation. Polymers , v. 14, p. 1392, 2022.
OTERO, ADA ISIS PELAEZ ; FERNANDES, JULIANA CAMPOS HASSE ; BORGES, TIAGO ; NASSANI, LEONARDO ; CASTILHO, ROGERIO DE MORAES ; FERNANDES, GUSTAVO VICENTIS DE OLIVEIRA . Sinus Lift Associated with Leucocyte-Platelet-Rich Fibrin (Second Generation) for Bone Gain: A Systematic Review. Journal of Clinical Medicine , v. 11, p. 1888, 2022.
SPULDARO, TOBIAS ; WAGNER, VIVIAN ; NÖR, FELIPE ; GAIO, EDUARDO ; SQUARIZE, CRISTIANE ; CARRARD, VINICIUS ; RÖSING, CASSIANO ; CASTILHO, ROGERIO . Periodontal disease affects oral cancer progression in a surrogate animal model for tobacco exposure. INTERNATIONAL JOURNAL OF ONCOLOGY , v. 60, p. 1-2, 2022.
DO NASCIMENTO GONÇALVES, NAIANE ; CALDAS, HELOISA CRISTINA ; DA SILVA FLORIM, GREICIANE MARIA ; SORMANI, GIOVANNA MATTIELLO ; ARANTES, LIDIA MARIA REBOLHO BATISTA ; SORROCHE, BRUNA PEREIRA ; BAPTISTA, MARIA ALICE SPERTO FERREIRA ; FERNANDES-CHARPIOT, IDA MARIA MAXIMINA ; NASCIMENTO-FILHO, CARLOS HENRIQUE VIESE ; DE CASTILHO, ROGÉRIO MORAES ; ABBUD-FILHO, MARIO . Distinct global DNA methylation and NF-κB expression profile of preimplantation biopsies from ideal and non-ideal kidneys. Journal Of Nephrology , v. 35, p. 1831-1840, 2022.
FERNANDES, PAULO RAFAEL ESTEVES ; OTERO, ADA ISIS PELAEZ ; FERNANDES, JULIANA CAMPOS HASSE ; NASSANI, LEONARDO MOHAMAD ; CASTILHO, ROGERIO MORAES ; DE OLIVEIRA FERNANDES, GUSTAVO VICENTIS . Clinical Performance Comparing Titanium and Titanium-Zirconium or Zirconia Dental Implants: A Systematic Review of Randomized Controlled Trials. DENTISTRY JOURNAL , v. 10, p. 83, 2022.
CONTI DE FREITAS, LUIZ C. ; Castilho, Rogerio M. ; Squarize, Cristiane H. . Histone Modification on Parathyroid Tumors: A Review of Epigenetics. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 23, p. 5378, 2022.
NASCIMENTO-FILHO, CARLOS H. V. ; GLINOS, ALEXANDRA T. ; JANG, YEEJIN ; GOLONI-BERTOLLO, ENY M. ; Castilho, Rogerio M. ; Squarize, Cristiane H. . From Tissue Physoxia to Cancer Hypoxia, Cost-Effective Methods to Study Tissue-Specific O2 Levels in Cellular Biology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 23, p. 5633, 2022.
EMERICK, CAROLINA ; MARIANO, FERNANDA VIVIANE ; Squarize, Cristiane H. ; Castilho, Rogerio M. . Spotlight on rare cancers. ORAL DISEASES , v. e, p. 1, 2022.
LARSSON, LENA ; KAVANAGH, NOLAN M. ; NGUYEN, TRANG V. N. ; Castilho, Rogerio M. ; BERGLUNDH, TORD ; GIANNOBILE, WILLIAM V. . Influence of epigenetics on periodontitis and peri-implantitis pathogenesis. PERIODONTOLOGY 2000 , v. 90, p. 125-137, 2022.
EMERICK, CAROLINA ; MARIANO, FERNANDA VIVIANE ; VARGAS, PABLO AGUSTIN ; NÖR, JACQUES E. ; Squarize, Cristiane H. ; Castilho, Rogerio M. . Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY , v. 179, p. 103792, 2022.
PARAG-SHARMA, KSHITIJ ; TASOULAS, JASON ; MUSICANT, ADELE M. ; DO NASCIMENTO-FILHO, CARLOS H. VIESI ; ZHU, ZHICHUAN ; TWOMEY, CHLOE ; LIU, PENGDA ; Castilho, Rogerio M. ; AMELIO, ANTONIO L. . Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma. ORAL ONCOLOGY , v. 115, p. 105166, 2021.
QU, LIU ; DUBEY, NILESHKUMAR ; RIBEIRO, JULIANA S. ; BORDINI, ESTER A.F. ; FERREIRA, JESSICA A. ; XU, JINPING ; Castilho, Rogerio M. ; BOTTINO, MARCO C. . Metformin-loaded nanospheres-laden photocrosslinkable gelatin hydrogel for bone tissue engineering. Journal of the Mechanical Behavior of Biomedical Materials , v. 116, p. 104293, 2021.
MOURA, ADRIANA CASTELO DE ; ASSAD, DANIELE XAVIER ; AMORIM DOS SANTOS, JULIANA ; PORTO DE TOLEDO, ISABELA ; BARRA, GUSTAVO BARCELOS ; CASTILHO, ROGERIO MORAES ; SQUARIZE, CRISTIANE HELENA ; GUERRA, ELIETE NEVES SILVA . Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY , v. 160, p. 103284, 2021.
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WEBBER, LIANA P. ; YIP, BRIAN ; NASCIMENTO FILHO, CARLOS H.V. DO ; PARK, HA B. ; Castilho, Rogerio M. ; Squarize, Cristiane H. . Topical delivery of mTOR inhibitor halts scarring. JOURNAL OF DERMATOLOGICAL SCIENCE , v. 95, p. 76-79, 2019.
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WAGNER, VIVIAN PETERSEN ; MARTINS, MANOELA DOMINGUES ; DILLENBURG, CAROLINE SIVIERO ; MEURER, LUISE ; CASTILHO, ROGERIO MORAES ; SQUARIZE, CRISTIANE HELENA . Histogenesis of keratoacanthoma: histochemical and immunohistochemical study. Oral Surgery Oral Medicine Oral Pathology Oral Radiology , v. 119, p. 310-317, 2015.
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PULLOS, A.N. ; CASTILHO, R.M. ; SQUARIZE, C.H. . HPV Infection of the Head and Neck Region and Its Stem Cells. JOURNAL OF DENTAL RESEARCH , v. 94, p. 1532-1543, 2015.
DILLENBURG, CAROLINE SIVIERO ; MARTINS, MANOELA DOMINGUES ; MEURER, LUISE ; CASTILHO, ROGERIO MORAES ; SQUARIZE, CRISTIANE HELENA . Keratoacanthoma of the Lip. MEDICINE , v. 94, p. e1552, 2015.
ADAMS, APRIL ; WARNER, KRISTY ; PEARSON, ALEXANDER T. ; ZHANG, ZHAOCHENG ; KIM, HONG SUN ; MOCHIZUKI, DAIKI ; BASURA, GREGORY ; HELMAN, JOSEPH ; MANTESSO, ANDREA ; CASTILHO, ROGÉRIO M. ; WICHA, MAX S. ; NÖR, JACQUES E. . ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas. Oncotarget , v. 6, p. 26633-26650, 2015.
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ALMEIDA, LUCIANA O. ; ABRAHAO, ALINE C. ; ROSSELLI-MURAI, LUCIANA K. ; GIUDICE, FERNANDA S. ; ZAGNI, CHIARA ; LEOPOLDINO, ANDREIA M. ; Squarize, Cristiane H. ; Castilho, Rogerio M. . NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC). FEBS Open Bio , v. 4, p. 96-104, 2014.
PELLICIOLI, ANA CAROLINA AMORIM ; MARTINS, MANOELA DOMINGUES ; DILLENBURG, CAROLINE SIVIERO ; MARQUES, MÁRCIA MARTINS ; Squarize, Cristiane H. ; Castilho, Rogerio M. . Laser phototherapy accelerates oral keratinocyte migration through the modulation of the mammalian target of rapamycin signaling pathway. JOURNAL OF BIOMEDICAL OPTICS , v. 19, p. 028002, 2014.
DILLENBURG, CAROLINE SIVIERO ; ALMEIDA, LUCIANA OLIVEIRA ; MARTINS, MANOELA DOMINGUES ; SQUARIZE, CRISTIANE HELENA ; CASTILHO, ROGERIO MORAES . Laser phototherapy triggers the production of reactive oxygen species in oral epithelial cells without inducing DNA damage. JOURNAL OF BIOMEDICAL OPTICS , v. 19, p. 048002, 2014.
DILLENBURG, CAROLINE SIVIERO ; MARTINS, MARCO ANTONIO TREVIZANI ; MUNERATO, MARIA CRISTINA ; MARQUES, MÁRCIA MARTINS ; CARRARD, VINÍCIUS COELHO ; FILHO, MANOEL SANT?ANA ; CASTILHO, ROGÉRIO MORAES ; MARTINS, MANOELA DOMINGUES . Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial. JOURNAL OF BIOMEDICAL OPTICS , v. 19, p. 068002, 2014.
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LE, J. M. ; SQUARIZE, C. H. ; Castilho, RM . Histone modifications: Targeting head and neck cancer stem cells. WORLD JOURNAL OF STEM CELLS , v. 6, p. 511, 2014.
GIUDICE, FERNANDA S. ; PINTO, DECIO S. ; NÖR, JACQUES E. ; Squarize, Cristiane H. ; Castilho, Rogerio M. . Inhibition of Histone Deacetylase Impacts Cancer Stem Cells and Induces Epithelial-Mesenchyme Transition of Head and Neck Cancer. Plos One , v. 8, p. e58672, 2013.
SALES, KU ; GIUDICE, FS ; CASTILHO, RM ; SALLES, FT ; SQUARIZE, CH ; ABRAHAO, AC ; PINTO, DS . Cyclin D1-induced proliferation is independent of beta-catenin in Head and Neck Cancer. Oral Diseases , v. 6, p. n/a-n/a, 2013.
CASTILHO, RM ; SQUARIZE, CH ; GUTKIND, JS . Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing. Oral Diseases , v. 6, p. n/a-n/a, 2013.
SQUARIZE, CRISTIANE H ; CASTILHO, ROGERIO M ; ABRAHAO, ALINE C ; MOLINOLO, ALFREDO ; LINGEN, MARK W ; GUTKIND, J SILVIO . PTEN Deficiency Contributes to the Development and Progression of Head and Neck Cancer. NEOPLASIA , v. 15, p. 461-471, 2013.
MARTINS, M. D. ; CASTILHO, R. M. . Histones: Controlling Tumor Signaling Circuitry.. Journal of Carcinogenesis and Mutagenesis , v. 29, p. 1-12, 2013.
WARNER, KRISTY A. ; ADAMS, APRIL ; BERNARDI, LISIANE ; NOR, CAROLINA ; FINKEL, KELSEY A. ; ZHANG, ZHAOCHENG ; MCLEAN, SCOTT A. ; HELMAN, JOSEPH ; WOLF, GREGORY T. ; DIVI, VASU ; QUEIMADO, LURDES ; KAYE, FREDERIC J. ; Castilho, Rogerio M. ; NÖR, JACQUES E. . Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. ORAL ONCOLOGY , v. 49, p. 1059-1066, 2013.
ROSSELLI-MURAI, LUCIANA K. ; ALMEIDA, LUCIANA O. ; ZAGNI, CHIARA ; GALINDO-MORENO, PABLO ; PADIAL-MOLINA, MIGUEL ; VOLK, SARAH L. ; MURAI, MARCELO J. ; RIOS, HECTOR F. ; Squarize, Cristiane H. ; Castilho, Rogerio M. . Periostin Responds to Mechanical Stress and Tension by Activating the MTOR Signaling Pathway. PLoS One , v. 8, p. e83580, 2013.
Squarize, Cristiane H. ; CASTILHO, R. M. ; Bugge, Thomas H. ; Gutkind, J. Silvio . Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models. Plos One , v. 5, p. e10643, 2010.
Castilho, Rogerio M. ; Squarize, Cristiane H. ; Leelahavanichkul, Kantima ; Zheng, Yi ; Bugge, Thomas ; Gutkind, J. Silvio . Rac1 Is Required for Epithelial Stem Cell Function during Dermal and Oral Mucosal Wound Healing but Not for Tissue Homeostasis in Mice. Plos One , v. 5, p. e10503, 2010.
ABRAHAO, ALINE CORREA ; Castilho, Rogerio M. ; Squarize, Cristiane H. ; Molinolo, Alfredo A. ; SANTOS-PINTO, DECIO DOS ; Gutkind, J. Silvio . A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. Oral Oncology (1997) , v. 46, p. 880-887, 2010.
Castilho, Rogerio M. ; Squarize, Cristiane H. ; Chodosh, Lewis A. ; Williams, Bart O. ; Gutkind, J. Silvio . mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging. Cell Stem Cell , v. 5, p. 279-289, 2009.
Molinolo, Alfredo A. ; Amornphimoltham, Panomwat ; Squarize, Cristiane H. ; Castilho, Rogerio M. ; Patel, Vyomesh ; Gutkind, J. Silvio . Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncology , v. 45, p. 324-334, 2009.
SQUARIZE, C. H. ; CASTILHO, R. M. ; Gutkind, J. S. . Chemoprevention and Treatment of Experimental Cowden's Disease by mTOR Inhibition with Rapamycin. Cancer Research (Chicago, Ill.) , v. 68, p. 7066-7072, 2008.
SQUARIZE, C. H. ; CASTILHO, R. M. ; GUTKIND, J. S. . Chemoprevention and Treatment of Experimental Cowden's Disease by mTOR Inhibition with Rapamycin. Cancer Research (Chicago, Ill.) , v. 68, p. 7066-7072, 2008.
Liu, H. ; Fergusson, M. M ; CASTILHO, R. M. ; Liu, J. ; Cao, L. ; Chen, J. ; Malide, D. ; Rovira, I. I. ; Schimel, D. ; Kuo, C. J. ; Gutkind, J. S. ; Hwang, P. M. ; Finkel, T. . Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging. Science (New York, N.Y.) , v. 317, p. 803-806, 2007.
Castilho, R M ; Squarize, C H ; Patel, V ; Millar, S E ; Zheng, Y ; Molinolo, A ; Gutkind, J S . Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene (Basingstoke) , v. 26, p. 5078-5085, 2007.
Squarize, C H ; Castilho, R M ; Sriuranpong V ; PINTO JR, D. S. ; Gutkind, J S . Molecular Cross-Talk between the NFκB and STAT3 Signaling Pathways in Head and Neck Squamous Cell Carcinoma. NEOPLASIA , v. 8, p. 733-746, 2006.
John R. Basile ; Castilho, Rogerio M. ; Vanessa P. Williams ; Gutkind, J. Silvio . Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , v. 103, p. 9017-9022, 2006.
Castilho, R M ; SQUARIZE, C. H. ; Nunes FD ; PINTO JR, D. S. . Osteolipoma: a rare lesion in the oral cavity. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY , v. 42, p. 363-364, 2004.
SQUARIZE, C. H. ; CASTILHO, R. M. ; PINTO JR, D. S. . Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system. JOURNAL OF ORAL PATHOLOGY & MEDICINE , v. 31, p. 379-384, 2002.
WAGNER, VIVIAN PETERSEN ; MARTINS, MANOELA DOMINGUES ; CASTILHO, ROGERIO MORAES . Histones Acetylation and Cancer Stem Cells (CSCs). Methods in Molecular Biology. 1ed.: Springer New York, 2018, v. , p. 179-193.
Castilho, Rogerio M. ; Gutkind, J. Silvio . The Wnt/ß-catenin Signaling Circuitry in Head and Neck Cancer. Molecular Determinants of Head and Neck Cancer. 1ed.: Springer New York, 2014, v. , p. 199-214.
SQUARIZE, C. H. ; Castilho, Rogerio M. ; LEOPOLDINO, A. M. . Drug Target Validation.. In: Carlton A. Taft, Carlos H. T. P. Silva. (Org.). Current Methods in Medicinal Chemistry and Biological Physics. 1ed.Trivandrum: Research Signpost, 2008, v. 2, p. 167-186.
Squarize, C H ; CASTILHO, R. M. . Emerging animal models.. In: Carlton A. Taft , Carlos H. T. P. Silva. (Org.). Current Methods in Medicinal Chemistry and Biological Physics.. 1ed.Trivandrum: Research Signpost, 2007, v. 1, p. 207-226.
SPINI, T. H. ; RODRIGUES, D. M. O. ; BORGES, C. ; CASTILHO, R. M. . Histiocitose. In: IX Congresso e XXVII Jornada Brasileira de Estomatologia, 2001, São Pedro. Anais do IX Congresso e XXVII Jornada Brasileira de Estomatologia. São Paulo: RGB Comunicação Artes Gráficas e Editora, 2001. p. 16-16.
ETGES, A. ; GIOVANINI, A. F. ; SOUZA, F. B. ; CASTILHO, R. M. ; MAGALHÃES, M. H. C. G. . Alterações periodontais e hiperplasia gengival generalizada em pacientes transplantada renal - Relato de caso. In: IX Congresso e XXVII Jornada Brasileira de Estomatologia, 2001, São Pedro. Anais do IX Congresso e XXVII Jornada Brasileira de Estomatologia. São Paulo: RGB Comunicações Artes Gráficas e Editora, 2001. p. 12-12.
PINTO JR, D. S. ; SQUARIZE, C. H. ; TUCCI, R. ; CASTILHO, R. M. . b-catenin regulation by LiCl in OSCC cell lines. Journal of Dental Research , Alexandria, VA, v. 81, n.Special, p. A-214-A-214, 2002.
SQUARIZE, C. H. ; CASTILHO, R. M. ; PINTO JR, D. S. . PTEN as a potential tumor marker in oral squamos cell carcinoma. Journal of Dental Research , Alexandria, VA, v. 81, n.Special, p. A-404-A-404, 2002.
SQUARIZE, C. H. ; CASTILHO, R. M. ; PINTO JR, D. S. . PTEN como marcador tumoral em carcinomas epidermóides bucais. Pesquisa Odontológica Brasileira , São Paulo, v. 15, n.suplemento, p. 13-13, 2001.
CASTILHO, R. M. ; TUCCI, R. ; SQUARIZE, C. H. ; RAMOS, A. A. ; PINTO JR, D. S. . Análise da aplicação de LiCl em 2 linhagens de carcinomas bucais. Pesquisa Odontológica Brasileira , São Paulo, v. 14, n.suplemento, p. 82-82, 2000.
CASTILHO, R. M. ; ARAÚJO, V. C. ; JAEGER, M. M. M. . Estudo da expressão do CD44 e do ácido hialurônico em adenomas pleomórficos. Pesquisa Odontológica Brasileira , São Paulo, v. 14, n.suplemento, p. 129-129, 2000.
TUCCI, R. ; CASTILHO, R. M. ; SQUARIZE, C. H. ; PINTO JR, D. S. . Análise da utilização do LiCl em 2 linhagens celulares de carcinomas epidermóides bucais. Revista de Pós-Graduação da Faculdade de Odontologia da Universidade de São Paulo , São Paulo, v. 7, n.suplemento, p. 27-27, 2000.
SQUARIZE, C. H. ; CASTILHO, R. M. ; PINTO JR, D. S. . Estudo comparativo da expressão imuno-histoquímica de PTEN em carcinomas epidermóides bucais e da graduação histológica de malignidade. Revista de Pós-Graduação da Faculdade de Odontologia da Universidade de São Paulo , São Paulo, v. 7, n.suplemento, p. 30-30, 2000.

Projetos de desenvolvimento

2010 - Atual

Analize do Processo de ativacao de Senescencia atravez da via de Sinalizacao do Wnt, Descrição: Usando modelos animais (transgenicos) o meu laboratorio esta explorando os mecanismos de ativacao de senescencia atravez da superexpressao de Wnt1 na camada basal do epithelio, focando particularmente na via de sinalizacao do mTOR que leva a ativacao de quebras das duas fitas do DNA e como consequencia a senescencia.. , Situação: Em andamento; Natureza: Desenvolvimento. , Integrantes: Rogério Moraes de Castilho - Coordenador / Cristiane Helena Squarize - Integrante / Silvio Gutkind - Integrante.
2010 - Atual

Analize do Processo de ativacao de Senescencia atravez da via de Sinalizacao do Wnt, Descrição: Usando modelos animais (transgenicos) o meu laboratorio esta explorando os mecanismos de ativacao de senescencia atravez da superexpressao de Wnt1 na camada basal do epithelio, focando particularmente na via de sinalizacao do mTOR que leva a ativacao de quebras das duas fitas do DNA e como consequencia a senescencia.. , Situação: Em andamento; Natureza: Desenvolvimento. , Integrantes: Rogério Moraes de Castilho - Coordenador / Cristiane Helena Squarize - Integrante / Silvio Gutkind - Integrante.
2010 - Atual

Analize do Processo de ativacao de Senescencia atravez da via de Sinalizacao do Wnt, Descrição: Usando modelos animais (transgenicos) o meu laboratorio esta explorando os mecanismos de ativacao de senescencia atravez da superexpressao de Wnt1 na camada basal do epithelio, focando particularmente na via de sinalizacao do mTOR que leva a ativacao de quebras das duas fitas do DNA e como consequencia a senescencia.. , Situação: Em andamento; Natureza: Desenvolvimento. , Integrantes: Rogério Moraes de Castilho - Coordenador / Cristiane Helena Squarize - Integrante / Silvio Gutkind - Integrante.

Prêmios

2001

Prêmio Hatton, Sociedade Brasileira de Pesquisa Odontológica -SBPqO.

Histórico profissional

Endereço profissional

University of Michigan, School of Dentistry. , 1101 N. University Ave Rm 2159, _, 481091078 - Ann Arbor, - Estados Unidos, Telefone: (734) 6472150, URL da Homepage:

Experiência profissional

2010 - Atual

University Of Michigan

Vínculo: Servidor Público, Enquadramento Funcional: Professor Assistente, Carga horária: 40, Regime: Dedicação exclusiva.

2019 - Atual

Universidade Estadual de Campinas

Vínculo: Professor Visitante, Enquadramento Funcional: Professor PermanentePesquisador colaborador, Carga horária: 1