JEN KAI YU

Idiomas

Orientou

Produções bibliográficas

• SONG, Y. ; Jen K.Y. ; SONI, V. ; KIEFF, E. ; CAHIR-MCFARLAND, E. . IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-B activation. PNAS. Proceedings of the National Academy of Sciences of the United States of America , USA, v. 103, n.8, p. 2689-2694, 2006.

• Jen K.Y. ; Higuchi M ; Cheng J. ; Li J ; Wu LY ; Li YF ; Chen ZL ; Gurtsevitch V ; Fujii M ; Saku T . Nucleotide sequence and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelial carcinomas. Virus Genes, USA, 2004.

• Jen K.Y. ; Cheng J. ; Takagi R ; Tanaka R ; Hayashi T ; Saku T . Central Hemangioma of Maxilla: Report of a case with exophytic growth. Oral Oncology EXTRA, London, 2004.

• Jen K.Y. ; Cheng J. ; Li J ; Wu LY ; Li YF ; Yu SF ; Li HL ; Chen ZL ; Gurtsevitch V ; Saku T . Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas. International Journal of cancer, USA, v. 105, p. 654-660, 2003.

• Saku T ; Cheng J. ; Jen K.Y. ; Tokunaga M ; Li J ; Zhang W ; Liu A ; Wu LY ; Lu Y ; Zhou Z . Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asian area: a clinicopathologic study of 160 cases. Archive of Pathology, Moscow, v. 65, p. 35-39, 2003.

• Metwaly H ; Cheng J. ; Ida H ; Ohshiro K ; Jen K.Y. ; Liu A ; Saku T . Endothelial Participation in formation of epimyoepithelial islands in bening lymphoepithelial lesion. Virchows Archiv, Heidelberger, v. 443, p. 17-27, 2003.

• Syafriadi M ; Ida H ; Maruyama S ; Jen K.Y. ; Cheng J. ; Takagi R ; Saku T . Carcinoma in-situ of the oral mucosa has a definite tendency towards keratinization. Oral Medicine and Pathology, Japan, v. 8, p. 43-44, 2003.

• Jen K.Y. ; Cheng J. ; Maruyama S ; Hayashi T ; Suzuki I ; Shingaki S ; Saku T . Mucoepidermoid carcinoma in children: report of a case and review of literature. Oral Medicine and Pathology, Nagoya, v. 7, p. 27-31, 2002.

• Naclerio Homem MG ; Deboni MCZ ; Jen K.Y. . Carcinoma espinocelular de maxila: relato de um caso clinico. JBC. Jornal Brasileiro de Clínica & Estética em Odontologia , Curitiba, v. 20, p. 83-85, 2000.

• Cheng J. ; Jen K.Y. ; Maruyama S ; Yamazaki M ; Zhou ST ; Zheng T ; Saku T . Molecular Pathology characterization of the salivary gland lymphoepithelial carcinoma cell line infected by EBV. In: Japanese Pathology congress, 2004, Sapporo, Hokkaido. Proceedings of the Japanese Society of Pathology, 2004. v. 93. p. 367-367.

• Syafriadi M ; Cheng J. ; Jen K.Y. ; Saku T . Histopathological classification for carcinoma in situ of the oral mucosa based on p53 mutational variations. In: Japanese Pathology congress, 2004, Sapporo, Hokkaido. Proceedings of the Japanese Society of Pathology, 2004. v. 93. p. 339-339.

• Jen K.Y. ; Cheng J. ; Saku T . Characterization for ECM molecules of two distinct types of the neoplastic stroma in oral squamous cell carcinoma. In: Japanese Pathology Congress, 2003, Fukuoka. Proceedings of the Japanese Society of Pathology, 2003. v. 92. p. 361-361.

• Jen K.Y. ; Cheng J. ; Saku T . The myxoid neoplastic stroma in salivary gland lymphoepithelial carcinomas may represent a barrier against T lymphocytes infiltration. In: Japanese Oral Biology congress, 2003, Morioka. Japanese Journal of Oral Biology, 2003. v. 45. p. 165-165.

• Jen K.Y. ; Cheng J. ; Saku T . Sequence variation of the LMP1 gene of EBV in salivary gland lymphoepithelial carcinomas from different regions of China and Russia. In: The second annual Mclaughlin symposium in infection and immunity: Epstein Barr virus (EBV) and Human Papilloma virus (HPV): oral infection, persistence and pathogenesis, 2003, Galveston, Tx. The second annual McLaughlin symposium in infection and immunity, 2003.

• Jen K.Y. ; Cheng J. ; Suzuki M ; Saku T . Intraductal Papilloma: report of a case. In: Japanese Oral Pathology congress, 2003, awajishima. 14th Annual Meeting of the Japanese Society for Oral pathology, 2003. p. 86-86.

• Jen K.Y. ; Cheng J. ; Saku T . Sequence analysis of the promoter region of the EBV LMP1 gene isolated from salivary gland lymphoepithelial carcinomas. In: Sixty second anual meeting of the Japanese cancer association, 2003, Nagoya. Sixty-second annual meeting of the Japanese cancer association, 2003.

• Jen K.Y. ; Cheng J. ; Saku T . Oral Papillary Endothelial hyperplasia: an immunoshitochemical demosntration of its pathogenesis. In: Japanese Pathology congress, 2002, yokohama. Proceedings of the Japanese Society of Pathology, 2002. v. 91. p. 329-329.

• Metwaly H ; Cheng J. ; Jen K.Y. ; Saku T . Endothelial participation in formation of epimyoepithelial islands in benign lymphoepithelial lesions. In: Japanse Pathology Congress, 2002, yokohama. Proceedings of the Japanese Society of Pathology, 2002. v. 91. p. 301.

• Jen K.Y. ; Cheng J. ; Saku T . Possible molecular mechanisms for EBV infection in salivary gland lymphoepithelial carcinomas. In: Japanese Oral Biology congress, 2002, Tokyo. Japanese Journal of Oral Biology, 2002. v. 44. p. 133-133.

• Wei JX ; Cheng J. ; Jen K.Y. ; Saku T . Overexpression of extracellular matrix molecules in metastatic adenoid cystic carcinoma cells of salivary gland origin. In: Japanese Journal of Oral Biology, 2002, Yokohama. Japanese Journal of Oral Biology, 2002. v. 44. p. 165-165.

• Jen K.Y. ; Cheng J. ; Li HL ; Li J ; Wu LY ; Li YF ; Yu SF ; Chen ZL ; Gurtsevitch V ; Saku T . Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas. In: International Congress of Oral Pathology, 2002, cingapura. IAOP-International Journal of Oral Pathology, 2002.

• Jen K.Y. ; Cheng J. ; Saku T . Central Hemangioma: report of a case. In: Japanese Oral pathology congress, 2002, Tokyo. 13th Annual Meeting of the Japanese Society for Oral Pathology, 2002. p. 33-33.

• Jen K.Y. ; Cheng J. ; Yagi M ; Saku T . Stromal characteristics of squamous cell carcinoma of the tongue compared between well and poorly-differentiated foci: an immunohistochemical study. In: Japanese congress of oral biology, 2001, Omiya. Japanese Journal of Oral Biology, 2001. v. 43. p. 184-184.

• Jen K.Y. ; Cheng J. ; Saku T . Mucoepidermoid carcinoma of children: report of a case and literature review. In: Japanese Oral Pathology congress, 2001, Kagoshima. 12th Annual meeting of the Japanese society for Oral Pathology, 2001. p. 25-25.

• Jen K.Y. ; Cheng J. ; Suzuki M ; Hayashi T ; Saku T . Tumor of palate. Oral Medicine and Pathology, Nagoya, v. 9, n.1, p. 48-48, 2004.

• Jen K.Y. ; Cheng J. ; Saku T . Sequence analysis of the promoter region of the EBV LMP1 gene isolated from salivary gland lymphoepithelial carcinomas. Cancer Science Supplement, Tokyo, v. 94, p. 53-53, 2003.

• Jen K.Y. ; Cheng J. ; Li J ; Wu LY ; Li YF ; Li HL ; Yu SF ; Chen ZL ; Gurtsevitch V ; Saku T . Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas. Journal of Oral Pathology and Medicine, Oxford, v. 31, p. 296-296, 2002.

• Jen K.Y. ; Cheng J. ; Hayashi T ; Tanaka R ; Takagi R ; Saku T . tumor of maxilla. Oral Medicine and Pathology, Nagoya, v. 7, n.2, p. 93-93, 2002.

Projetos de pesquisa

• 2005 - Atual

  Pesquisa de mutações no gene hMLH1 de pacientes com carcinoma de células escamosas de cabeça e pescoço, Descrição: Alterações no gene hMLH1 (human Mut L homolog 1) são observadas em 60% dos casos de câncer de colo não poliposo hereditário (HNPCC). Essas alterações incluem substituições de bases, deleções e inserções de nucleotídeos, além de polimorfismos, nos exons 2, 4, 5, 8, 13, 14, 15, 16, 17 e 19 de pacientes com HNPCC. Entretanto, não há um hot spot específico no gene hMLH1 que esteja associado a um aumento no risco desses tumores. A deficiência da proteína MLH1 está associada à instabilidade de seqüências microssatélites. Os microssatélites são seqüências de DNA altamente polimórficas compostas por motivos de repetições com até 6 nucleotídeos. Essas seqüências estão dispersas por todo o genoma e tendem a acumular mutações por erro de replicação. O acúmulo alterações somáticas nos microssatélites caracteriza a instabilidade de microssatélites (MSI) que serve de evidência para detecção da via de tumorigênese por fenótipo mutante. Adicionalmente, a ocorrência de MSI em regiões codificadoras de proteínas resulta em alteração do quadro de leitura e freqüente inativação protéica. Recentemente, nossa equipe de pesquisa investigou e detectou MSI em pacientes com HNSCC (Silva Jr. et al., dados não publicados), mas estudos complementares quanto aos genes de MMR desses pacientes não foram realizados. A justificativa para realização desta proposta de estudo é que mutações no gene hMLH1 podem estar envolvidas no desenvolvimento e progressão do carcinomas de células escamosas de cabeça e pescoço (HNSCC). Assim, este estudo visa investigar o envolvimento de mutações no gene hMLH1 em pacientes com HNSCC. . , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) / Especialização: (1) . , Integrantes: Jen Kai Yu - Integrante / Flávio Monteiro Ayres - Coordenador / Aparecido Divino da Cruz - Integrante.

Prêmios