Juliana Bosso Taniguchi

My research experience has provided me opportunities to work in different countries with researchers from all over the world. As a graduate student in pharmacy-biochemistry, I was able to do an internship at Center for Neglected Diseases at Institut Pasteur Korea working on High Content Screening for Dengue and Chikungunya virus. From this work, we found compounds that inhibits the viral infection that resulted in two publications. In 2013, I started my studies in Japan, first as a research student and, from 2014 to 2018, as a PhD candidate at Department of Neuropathology at Tokyo Medical and Dental University, working on gene therapy in an animal model of a polyglutamine disease called spinocerebellar ataxia. During my time in Japan, I gained expertise in DNA damage and repair, gene therapy and adeno-associated virus. From this work, we published an article suggesting a new therapy for spinocerebellar ataxia type 1. From this publication, I received a research award at a young scientist workshop in 2017. From 2018 to 2019, I joined a new translational research program focused on the investigation of disease mechanism of inherited peripheral neuropathies (Charcot-Marie-Tooth disease ? CMT) using cellular reprogramming and differentiation techniques to generate patient-specific neuronal cultures for disease modeling.

Informações coletadas do Lattes em 21/08/2022

Acadêmico

Formação acadêmica

Doutorado em Neuropatologia

2014 - 2018

Tokyo Medical And Dental University
Título: RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair
Orientador: Hitoshi Okazawa
Bolsista do(a): The Nippon Foundation, TNF, Japão. Palavras-chave: Gene therapy; SCA1; RpA1.

Especialização em Internship on scientific research of drug discovery for Neglected Diseases

2011 - 2012

Institut Pasteur Korea, IP-Korea
Título: High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses
Bolsista do(a): Institut Pasteur Korea, IPK, Coréia do Sul.

Graduação em andamento em Medicina

2021 - Atual

Universidade de Passo Fundo

Graduação em Farmácia-Bioquímica

2007 - 2012

Universidade Estadual Paulista Júlio de Mesquita Filho
Título: Analise da Qualidade de Vida de Pacientes com a Doenca de Charcot-Marie-Tooth Tipo 1A
Orientador: Wilson Marques Junior
Bolsista do(a): Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Brasil.

Graduação interrompida em 2007 em Informática Biomédica

2004 - Atual

Universidade de São Paulo
Ano de interrupção: 2007

Pós-doutorado

2018 - 2019

Pós-Doutorado. , University of Miami, UMiami, Estados Unidos. , Grande área: Ciências Biológicas, Grande Área: Ciências da Saúde / Área: Medicina / Subárea: neurologia.

Formação complementar

2011 - 2012

Internship exchange program. (Carga horária: 600h). , Institut Pasteur Korea, IP-Korea, Coréia do Sul.

2009 - 2009

Genoma, Proteoma e o Universo Celular. (Carga horária: 80h). , Universidade de São Paulo, USP, Brasil.

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Espanhol

Compreende Bem, Fala Razoavelmente, Lê Bem, Escreve Razoavelmente.

Japonês

Compreende Pouco, Fala Pouco, Lê Pouco, Escreve Pouco.

Áreas de atuação

Grande área: Ciências Biológicas / Área: Genética / Subárea: iPS cells.

Grande área: Ciências Biológicas / Área: Genética / Subárea: CRISPR.

Grande área: Ciências Biológicas / Área: Genética / Subárea: neurologia.

Grande área: Ciências Biológicas / Área: Parasitologia / Subárea: High Content Screening.

Participação em eventos

Oral presentation at The 9th Symposium of Youth Inspiration CBIR and ONSA. The Center for Brain Integration Research and Ochanomizu NeuroScience Association.RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. 2017. (Simpósio).

Oral presentation at Young Scientist Workshop of MRI FY2016. Medical Research Institute, Tokyo Medical and Dental University.RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. 2017. (Oficina).

The 40th Annual Meeting of the Japan Neuroscience Society.RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. 2017. (Encontro).

XXIII World Congress of Neurology. RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. 2017. (Congresso).

Oral presentation at the 1st French-Brazilian Symposium on Biosciences.High Throughput Screening for Dengue Antivirals using IP Korea?s Image-based High Throughput - High Content Assay (HT-HCA).. 2012. (Simpósio).

Poster at the 17th International Symposium on undergraduate research, USP.Analysis of quality of life of patients with Charcot-Marie-Tooth disease type 1A. 2009. (Simpósio).

1 Encontro Nacional de Química Forense. 2008. (Encontro).

55 Jornada Farmacêutica. 2008. (Outra).

I Semana da Informática Biomédica. 2004. (Outra).

Produções bibliográficas

MACIEL, RENATA ; CORREA, RENATA ; BOSSO TANIGUCHI, JULIANA ; PRUFER ARAUJO, IGOR ; SAPORTA, MARIO A. . Human Tridimensional Neuronal Cultures for Phenotypic Drug Screening in Inherited Peripheral Neuropathies. CLINICAL PHARMACOLOGY & THERAPEUTICS , v. 107, p. 1231-1239, 2020.
TANIGUCHI, JULIANA BOSSO ; KONDO, KANOH ; FUJITA, KYOTA ; CHEN, XIGUI ; HOMMA, HIDENORI ; SUDO, TAKEAKI ; MAO, YING ; WATASE, KEI ; TANAKA, TOSHIHIRO ; TAGAWA, KAZUHIKO ; TAMURA, TAKUYA ; MURAMATSU, SHIN-ICHI ; OKAZAWA, HITOSHI . RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. Human Molecular Genetics (Print) , v. 1, p. ddw272, 2016.
IMAMURA, TOMOMI ; FUJITA, KYOTA ; TAGAWA, KAZUHIKO ; IKURA, TEIKICHI ; CHEN, XIGUI ; HOMMA, HIDENORI ; TAMURA, TAKUYA ; MAO, YING ; TANIGUCHI, JULIANA BOSSO ; MOTOKI, KAZUMI ; NAKABAYASHI, MAKOTO ; ITO, NOBUTOSHI ; YAMADA, KAZUNORI ; TOMII, KENTARO ; OKANO, HIDEYUKI ; KAYE, JULIA ; FINKBEINER, STEVEN ; OKAZAWA, HITOSHI . Identification of hepta-histidine as a candidate drug for Huntington?s disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Scientific Reports , v. 6, p. 33861, 2016.
CRUZ, DEU JOHN M. ; KOISHI, ANDREA CRISTINE ; TANIGUCHI, JULIANA BOSSO ; LI, XIAOLAN ; MILAN BONOTTO, RAFAELA ; NO, JOO HWAN ; KIM, KEUM HYUN ; BAEK, SUNGMIN ; KIM, HEE YOUNG ; WINDISCH, MARC PETER ; PAMPLONA MOSIMANN, ANA LUIZA ; DE BORBA, LUANA ; LIUZZI, MICHEL ; HANSEN, MICHAEL ADSETTS EDBERG ; NUNES DUARTE DOS SANTOS, CLAUDIA ; FREITAS-JUNIOR, LUCIO HOLANDA . High Content Screening of a Kinase-Focused Library Reveals Compounds Broadly-Active against Dengue Viruses. PLoS Neglected Tropical Diseases (Online) , v. 7, p. e2073, 2013.
TANIGUCHI, JULIANA B. ; ELUI, VALERIA M.C. ; OSORIO, FLAVIA L. ; HALLAK, JAIME E.C. ; CRIPPA, JOSE A.S. ; MACHADO-DE-SOUSA, JOAO P. ; KEBBE, LEONARDO M. ; LOURENCO, CHARLES M. ; SCAREL-CAMINAGA, RAQUEL M. ; MARQUES JR, WILSON . Quality of life in patients with Charcot-Marie-Tooth disease type 1A. Arquivos de Neuro-Psiquiatria (Impresso) , v. 71, p. 392-396, 2013.
CRUZ, DEU JOHN M. ; BONOTTO, RAFAELA M. ; GOMES, RAFAEL G. B. ; DA SILVA, CAMILA T. ; TANIGUCHI, JULIANA B. ; NO, JOO HWAN ; LOMBARDOT, BENOIT ; SCHWARTZ, OLIVIER ; HANSEN, MICHAEL A. E. ; FREITAS-JUNIOR, LUCIO H. . Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library. PLoS Neglected Tropical Diseases (Online) , v. 7, p. e2471, 2013.

Prêmios

2017

Best Oral Presentation Award, 3rd place, Oral presentation at The 9th Symposium of Youth Inspiration CBIR and ONSA.

2017

Best Oral Presentation Award, 3rd place, Oral presentation at Young Scientist Workshop of MRI FY2016. Medical Research Institute, TMDU.

2017

Research Award, Oral presentation at Young Scientist Workshop of MRI FY2016. Medical Research Institute, TMDU.