Antonio Carlos Bianco

Idiomas

Áreas de atuação

Orientou

Produções bibliográficas

• FONSECA, TATIANA L. ; GARCIA, TZINTZUNI ; FERNANDES, GUSTAVO W. ; NAIR, T. MURLIDHARAN ; Bianco, Antonio C. . Neonatal thyroxine activation modifies epigenetic programming of the liver. Nature Communications , v. 12, p. 4446, 2021.

• SHAKIR, MOHAMED K M ; BROOKS, DANIEL I ; MCANINCH, ELIZABETH A ; FONSECA, TATIANA L ; MAI, VINH Q ; Bianco, Antonio C ; HOANG, THANH D . Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM , v. 106, p. e4400-e4413, 2021.

• IDREES, THAER ; PRIETO, WESLEY H ; CASULA, SABINA ; AJITH, ASWATHY ; ETTHELSON, MATTHEW ; ANDREOTTI NARCHI, FLAVIA A ; RUSSO, PEDRO S T ; FERNANDES, FERNANDO ; JOHNSON, JULIE ; MAYAMPURATH, ANOOP ; MACIEL, RUI M B ; Bianco, Antonio C . Use of Statins Among Patients Taking Levothyroxine: An Observational Drug Utilization Study Across Sites. Journal Of The Endocrine Society , v. 7, p. 5, 2021.

• ETTLESON, MATTHEW D ; Bianco, Antonio C ; ZHU, MENGQI ; LAITEERAPONG, NEDA . Sociodemographic Disparities in the Treatment of Hypothyroidism: NHANES 2007-2012. Journal Of The Endocrine Society , v. 5, p. 5, 2021.

• BUTTERFIELD, NATALIE C. CURRY, KATHERINE F. STEINBERG, JULIA DEWHURST, HANNAH KOMLA-EBRI, DAVIDE MANNAN, NAILA S. ADOUM, ANNE-TOUNSIA LEITCH, VICTORIA D. LOGAN, JOHN G. WAUNG, JULIAN A. GHIRARDELLO, ELENA SOUTHAM, LORRAINE YOULTEN, SCOTT E. WILKINSON, J. MARK MCANINCH, ELIZABETH A. VANCOLLIE, VALERIE E. KUSSY, FIONA WHITE, JACQUELINE K. LELLIOTT, CHRISTOPHER J. ADAMS, DAVID J. JACQUES, RICHARD Bianco, Antonio C. BOYDE, ALAN ZEGGINI, ELEFTHERIA CROUCHER, PETER I. , et al. WILLIAMS, GRAHAM R. BASSETT, J. H. DUNCAN ; Publisher Correction: Accelerating functional gene discovery in osteoarthritis. Nature Communications , v. 12, p. 3302, 2021.

• IDREES, THAER ; Bianco, Antonio C . Letter to the Editor from Idrees and Bianco: -Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis-. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM , v. 106, p. e3785-e3786, 2021.

• JONKLAAS, JACQUELINE ; BIANCO, ANTONIOC. ; CAPPOLA, ANNER. ; CELI, FRANCESCOS. ; FLIERS, ERIC ; HEUER, HEIKE ; MCANINCH, ELIZABETHA. ; MOELLER, LARSC. ; NYGAARD, BIRTE ; SAWKA, ANNAM. ; WATT, TORQUIL ; DAYAN, COLINM. . Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. european thyroid journal , v. 10, p. 10-38, 2021.

• RUSSO, SAMUEL C ; SALAS-LUCIA, FEDERICO ; Bianco, Antonio C . Deiodinases and the Metabolic Code for Thyroid Hormone Action. ENDOCRINOLOGY , v. 162, p. 1, 2021.

• BUTTERFIELD, NATALIE C. CURRY, KATHERINE F. STEINBERG, JULIA DEWHURST, HANNAH KOMLA-EBRI, DAVIDE MANNAN, NAILA S. ADOUM, ANNE-TOUNSIA LEITCH, VICTORIA D. LOGAN, JOHN G. WAUNG, JULIAN A. GHIRARDELLO, ELENA SOUTHAM, LORRAINE YOULTEN, SCOTT E. WILKINSON, J. MARK MCANINCH, ELIZABETH A. VANCOLLIE, VALERIE E. KUSSY, FIONA WHITE, JACQUELINE K. LELLIOTT, CHRISTOPHER J. ADAMS, DAVID J. JACQUES, RICHARD Bianco, Antonio C. BOYDE, ALAN ZEGGINI, ELEFTHERIA CROUCHER, PETER I. , et al. WILLIAMS, GRAHAM R. BASSETT, J. H. DUNCAN ; Accelerating functional gene discovery in osteoarthritis. Nature Communications , v. 12, p. 467, 2021.

• E MARCONDES, A. A. ; GOMEZ, T. G. B. ; RAVACHE, T. T. ; BATISTUZZO, A. ; LORENA, F. B. ; DE PAULA, C. S. ; LOWENTHAL, R. ; BIANCO, A. C. ; RIBEIRO, M. O. . Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION , v. 44, p. 1775-1782, 2021.

• JONKLAAS, JACQUELINE ; Bianco, Antonio C. ; CAPPOLA, ANNE R. ; CELI, FRANCESCO S. ; FLIERS, ERIC ; HEUER, HEIKE ; MCANINCH, ELIZABETH A. ; MOELLER, LARS C. ; NYGAARD, BIRTE ; SAWKA, ANNA M. ; WATT, TORQUIL ; DAYAN, COLIN M. . Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. THYROID , v. 31, p. 156-182, 2021.

• SAWKA, ANNA M. ; ALEXANDER, ERIK K. ; Bianco, Antonio C. ; CHOU, ROGER ; HAUGEN, BRYAN R. ; KOPP, PETER A. ; PEARCE, ELIZABETH N. ; ROSS, DOUGLAS S. ; SMALLRIDGE, ROBERT C. ; JONKLAAS, JACQUELINE . Challenges in Developing Recommendations Based on Low-Quality Evidence in Thyroid Guidelines. THYROID , v. 31, p. 3-7, 2021.

• FRANÇA, MONICA M. ; GERMAN, ALINA ; FERNANDES, GUSTAVO W. ; LIAO, XIAO-HUI ; Bianco, Antonio C. ; REFETOFF, SAMUEL ; DUMITRESCU, ALEXANDRA M. . Human Type 1 Iodothyronine Deiodinase ( ) Mutations Cause Abnormal Thyroid Hormone Metabolism. THYROID , v. 31, p. 202-207, 2021.

• BELTRÃO, FABYAN ESBERARD DE LIMA ; BELTRÃO, DANIELE CARVALHAL DE ALMEIDA ; CARVALHAL, GIULIA ; BELTRÃO, FABRICIA ELIZABETH DE LIMA ; BRITO, AMANDA DA SILVA ; CAPISTRANO, KAMILLA HELEN RODRIGUES DA ; BASTOS, ISIS HENRIQUES DE ALMEIDA ; HECHT, FABIO ; DALTRO, CARLA HILÁRIO DA CUNHA ; BIANCO, ANTONIO CARLOS ; GONÇALVES, MARIA DA CONCEIÇÃO RODRIGUES ; RAMOS, HELTON ESTRELA . Thyroid Hormone Levels During Hospital Admission Inform Disease Severity and Mortality in COVID-19 Patients. THYROID , v. 31, p. 1639-1649, 2021.

• MARCELINO, CÍCERA P ; MCANINCH, ELIZABETH A ; FERNANDES, GUSTAVO W ; BOCCO, BARBARA M L C ; RIBEIRO, MIRIAM O ; Bianco, Antonio C . Temporal Pole Responds to Subtle Changes in Local Thyroid Hormone Signaling. Journal Of The Endocrine Society , v. 4, p. 1, 2020.

• BOCCO, BARBARA M L C ; FERNANDES, GUSTAVO W ; FONSECA, TATIANA L ; Bianco, Antonio C . Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice. ENDOCRINOLOGY , v. 161, p. 1, 2020.

• ETTLESON, MATTHEW D ; Bianco, Antonio C . Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone?. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM , v. 105, p. e3090-e3104, 2020.

• IDREES, THAER ; PALMER, SCOTT ; Maciel, Rui M.B. ; Bianco, Antonio C. . Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism. THYROID , v. 30, p. 1399-1413, 2020.

• Bianco, Antonio C. . We All Know We Need Them, We Hope They Are Coming, But When?. THYROID , v. 30, p. 791-793, 2020.

• Bianco, Antonio C ; TAYLOR, PETER . Levothyroxine treatment and cholesterol in hypothyroidism. Nature Reviews Endocrinology , v. 16, p. 193-194, 2020.

• MCKEEVER, LIAM ; PETERSON, SARAH J ; LATEEF, OMAR ; FREELS, SALLY ; FONSECA, TATIANA L ; BOCCO, BARBARA M L C ; FERNANDES, GUSTAVO W ; ROEHL, KELLY ; NOWAK, KRISTEN ; MOZER, MARISA ; Bianco, Antonio C ; BRAUNSCHWEIG, CAROL A . Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM , v. 105, p. 523-533, 2020.

• SAWKA, ANNA M. ; CAPPOLA, ANNE R. ; PEETERS, ROBIN P. ; KOPP, PETER A. ; Bianco, Antonio C. ; JONKLAAS, JACQUELINE . Patient Context and Thyrotropin Levels Are Important When Considering Treatment of Subclinical Hypothyroidism. THYROID , v. 29, p. 1359-1363, 2019.

• IDREES, THAER ; PRICE, JOHN D. ; PICCARIELLO, THOMAS ; Bianco, Antonio C. . Sustained Release T3 Therapy: Animal Models and Translational Applications. Frontiers in Endocrinology , v. 10, p. 544, 2019.

• MCANINCH, ELIZABETH A. ; Bianco, Antonio C. . The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination Therapy. Frontiers in Endocrinology , v. 10, p. 446, 2019.

• TAYLOR, PETER ; Bianco, Antonio C. . Urgent need for further research in subclinical hypothyroidism. Nature Reviews Endocrinology , v. 15, p. 503-504, 2019.

• Bianco, Antonio C ; DUMITRESCU, ALEXANDRA ; Gereben, Balázs ; RIBEIRO, MIRIAM O ; FONSECA, TATIANA L ; FERNANDES, GUSTAVO W ; BOCCO, BARBARA M L C . Paradigms of Dynamic Control of Thyroid Hormone Signaling. ENDOCRINE REVIEWS , v. 40, p. 1000-1047, 2019.

• FONSECA, TATIANA L. ; FERNANDES, GUSTAVO W. ; BOCCO, BARBARA M. L. C. ; KESHAVARZIAN, ALI ; JAKATE, SHRIRAM ; DONOHUE, TERRENCE M. ; Gereben, Balázs ; Bianco, Antonio C. . Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH , v. 43, p. 1376-1383, 2019.

• Jo, Sungro ; FONSECA, TATIANA L. ; BOCCO, BARBARA M. L. C. ; FERNANDES, GUSTAVO W. ; MCANINCH, ELIZABETH A. ; BOLIN, ANAYSA P. ; DA CONCEIÇÃO, RODRIGO R. ; WERNECK-DE-CASTRO, JOAO PEDRO ; IGNACIO, DANIELE L. ; Egri, Péter ; NÉMETH, DOROTTYA ; FEKETE, CSABA ; BERNARDI, MARIA MARTHA ; LEITCH, VICTORIA D. ; MANNAN, NAILA S. ; CURRY, KATHARINE F. ; BUTTERFIELD, NATALIE C. ; BASSETT, J.H. DUNCAN ; WILLIAMS, GRAHAM R. ; Gereben, Balázs ; Ribeiro, Miriam O. ; Bianco, Antonio C. . Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain. JOURNAL OF CLINICAL INVESTIGATION , v. 129, p. 230-245, 2019.

• TROHMAN, RICHARD G. ; SHARMA, PARIKSHIT S. ; MCANINCH, ELIZABETH A. ; Bianco, Antonio C. . Amiodarone and thyroid physiology, pathophysiology, diagnosis and management. TRENDS IN CARDIOVASCULAR MEDICINE , v. 29, p. 285-295, 2019.

• DA CONCEIÇÃO, RODRIGO RODRIGUES ; FERNANDES, GUSTAVO WERPEL ; FONSECA, TATIANA ; BOCCO, BARBARA ; BIANCO, ANTONIO CARLOS . METAL COORDINATED POLY-ZINC-LIOTHYRONINE PROVIDES STABLE CIRCULATING T3 LEVELS IN HYPOTHYROID RATS. THYROID , v. 28, p. 1425-1433, 2018.

• MCANINCH, ELIZABETH A ; RAJAN, KUMAR B ; MILLER, CORINNE H ; Bianco, Antonio C . Systemic Thyroid Hormone Status During Levothyroxine Therapy In Hypothyroidism: A Systematic Review and Meta-Analysis. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM , v. 103, p. 4533-4542, 2018.

• MCANINCH, ELIZABETH A ; GLUECK, JENNIFER S ; Bianco, Antonio C . Does Sex Bias Play a Role for Dissatisfied Patients With Hypothyroidism?. Journal Of The Endocrine Society , v. 2, p. 970-973, 2018.

• Bianco, Antonio C. ; KIM, BRIAN S. . Pathophysiological relevance of deiodinase polymorphism. Current Opinion in Endocrinology Diabetes and Obesity , v. 25, p. 341-346, 2018.

• NASCIMENTO, BRUNA P P ; BOCCO, BARBARA M L C ; FERNANDES, GUSTAVO W ; FONSECA, TATIANA L ; MCANINCH, ELIZABETH A ; CARDOSO, CAROLINA V ; BONDAN, EDUARDO F ; NASSIF, RENATA J ; CYSNEIROS, ROBERTA M ; Bianco, Antonio C ; RIBEIRO, MIRIAM O . Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice. Endocrinology , v. 159, p. 3090-3104, 2018.

• PETERSON, SARAH J. ; CAPPOLA, ANNE R. ; CASTRO, M. REGINA ; DAYAN, COLIN M. ; FARWELL, ALAN P. ; HENNESSEY, JAMES V. ; KOPP, PETER A. ; ROSS, DOUGLAS S. ; SAMUELS, MARY H. ; SAWKA, ANNA M. ; TAYLOR, PETER N. ; JONKLAAS, JACQUELINE ; Bianco, Antonio C. . An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction. THYROID , v. 28, p. 707-721, 2018.

• MCANINCH, ELIZABETH A ; RAJAN, KUMAR B ; EVANS, DENIS A ; Jo, Sungro ; CHAKER, LAYAL ; PEETERS, ROBIN P ; BENNETT, DAVID A ; MASH, DEBORAH C ; Bianco, Antonio C . A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM , v. 103, p. 1818-1826, 2018.

• CHAKER, LAYAL ; Bianco, Antonio C ; JONKLAAS, JACQUELINE ; PEETERS, ROBIN P . Hypothyroidism and hypertension: fact or myth? - Authors' reply. LANCET , v. 391, p. 30, 2018.

• FERNANDES, GUSTAVO W. ; BOCCO, BARBARA M.L.C. ; FONSECA, TATIANA L. ; MCANINCH, ELIZABETH A. ; Jo, Sungro ; LARTEY, LATTOYA J. ; O-SULLIVAN, INSUG ; UNTERMAN, TERRY G. ; PREITE, NAILLIW Z. ; VOIGT, ROBIN M. ; FORSYTH, CHRISTOPHER B. ; KESHAVARZIAN, ALI ; SINKÓ, RICHÁRD ; Goldfine, Allison B. ; PATTI, MARY E. ; Ribeiro, Miriam O. ; Gereben, Balázs ; Bianco, Antonio C. . The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. Cell Reports , v. 22, p. 523-534, 2018.

• MOHÁCSIK, PETRA ; ERDÉLYI, FERENC ; BARANYI, MÁRIA ; BOTZ, BÁLINT ; SZABÓ, GÁBOR ; TÓTH, MÓNIKA ; HALTRICH, IRÉN ; HELYES, ZSUZSANNA ; SPERLÁGH, BEÁTA ; TÓTH, ZSUZSA ; SINKÓ, RICHÁRD ; LECHAN, RONALD M ; Bianco, Antonio C ; FEKETE, CSABA ; Gereben, Balázs . A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action. Endocrinology , v. 159, p. 1159-1171, 2018.

• YU, GUOYING ; TZOUVELEKIS, ARGYRIS ; WANG, RONG ; HERAZO-MAYA, JOSE D ; IBARRA, GABRIEL H ; SRIVASTAVA, ANUP ; DE CASTRO, JOAO PEDRO WERNECK ; DEIULIIS, GIUSEPPE ; AHANGARI, FARIDA ; WOOLARD, TONY ; AURELIEN, NACHELLE ; Arrojo e Drigo, Rafael ; GAN, YE ; GRAHAM, MORVEN ; LIU, XINRAN ; HOMER, ROBERT J ; SCANLAN, THOMAS S ; MANNAM, PRAVEEN ; LEE, PATTY J ; HERZOG, ERICA L ; Bianco, Antonio C ; KAMINSKI, NAFTALI . Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. NATURE MEDICINE , v. 24, p. 39-49, 2018.

• PAOLINO, BRUNO ; POMERANTZEFF, PABLO MARIA ; DALLAN, LUIZ ALBERTO O ; GAIOTTO, FABIO ANTONIO ; ZANINI PREITE, NAILLIW ; LATRONICO, ANA CLAUDIA ; NICOLAU, JOSE CARLOS ; BIANCO, ANTONIO CARLOS ; GIRALDEZ, ROBERTO . MYOCARDIAL INACTIVATION OF THYROID HORMONES IN PATIENTS WITH AORTIC STENOSIS. Thyroid (New York, N.Y.) , v. 27, p. thy.2016.0514, 2017.

• CHAKER, LAYAL ; Bianco, Antonio C ; JONKLAAS, JACQUELINE ; PEETERS, ROBIN P . Hypothyroidism. LANCET , v. 390, p. 1550-1562, 2017.

• BOCCO, B.M. ; FERNANDES, G.W. ; LORENA, F.B. ; CYSNEIROS, R.M. ; CHRISTOFFOLETE, M.A. ; GRECCO, S.S. ; LANCELLOTTI, C.L. ; ROMOFF, P. ; LAGO, J.H.G. ; BIANCO, A.C. ; RIBEIRO, M.O. . Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice. Brazilian journal of medical and biological research , v. 49, p. 1, 2016.

• MCANINCH, ELIZABETH A. ; Bianco, Antonio C. . The History and Future of Treatment of Hypothyroidism. Annals of Internal Medicine , v. 164, p. 50-56, 2016.

• IGNACIO, DANIELLE LEAO ; SILVESTRE, DIEGO HENRIQUE ; PALMER, ELENA ; BOCCO, BARBARA ; FONSECA, TATIANA ; GEREBEN, BALAZS ; RIBEIRO, MIRIAM ; BIANCO, ANTONIO CARLOS ; WERNECK DE CASTRO, JOAO PEDRO . Early developmental disruption of type 2 deiodinase pathway in mouse skeletal muscle does not impair muscle function. Thyroid (New York, N.Y.) , v. 26, p. 1, 2016.

• RAJAN, KUMAR B. ; ARVANITAKIS, ZOE ; LYNCH, ELIZABETH B. ; MCANINCH, ELIZABETH A. ; WILSON, ROBERT S. ; WEUVE, JENNIFER ; BARNES, LISA L. ; Bianco, Antonio C. ; EVANS, DENIS A. . Cognitive decline following incident and preexisting diabetes mellitus in a population sample. Neurology (Cleveland, Ohio) , v. 87, p. 1681-1687, 2016.

• BOCCO, BARBARA M. L. C. ; PEDRO WERNECK-DE-CASTRO, JOÃO ; OLIVEIRA, KELEN C. ; FERNANDES, GUSTAVO W. ; FONSECA, TATIANA L. ; NASCIMENTO, BRUNA P. P. ; MCANINCH, ELIZABETH A. ; RICCI, ESTHER ; KVÁRTA-PAPP, ZSUZSANNA ; FEKETE, CSABA ; MARTHA BERNARDI, MARIA ; Gereben, Balázs ; Bianco, Antonio C. ; Ribeiro, Miriam O. . Type 2 deiodinase disruption in astrocytes results in anxiety-depressive-like behavior in male mice. Endocrinology (Philadelphia) , v. 1, p. en.2016-1272, 2016.

• BOCCO, BARBARA M. L. C. ; LOUZADA, RUY A. N. ; SILVESTRE, DIEGO H. S. ; SANTOS, MARIA C. S. ; ANNE-PALMER, ELENA ; RANGEL, IGOR F. ; ABDALLA, SHERINE ; FERREIRA, ANDREA C. ; Ribeiro, Miriam O. ; Gereben, Balázs ; CARVALHO, DENISE P. ; Bianco, Antonio C. ; WERNECK-DE-CASTRO, JOÃO P. . Thyroid hormone activation by type2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor- coactivator-1 expression in skeletal muscle. Journal of Physiology (London. Print) , v. 594, p. 5255-5269, 2016.

• MCANINCH, ELIZABETH A. ; Jo, Sungro ; PREITE, NAILLIW Z. ; FARKAS, ERZSÉBET ; MOHÁCSIK, PETRA ; FEKETE, CSABA ; Egri, Péter ; Gereben, Balázs ; LI, YAN ; DENG, YOUPING ; Patti, Mary-Elizabeth ; ZEVENBERGEN, CHANTAL ; PEETERS, ROBIN P. ; MASH, DEBORAH C. ; Bianco, Antonio C. . Prevalent Polymorphism in Thyroid Hormone-Activating Enzyme Leaves a Genetic Fingerprint That Underlies Associated Clinical Syndromes. The Journal of Clinical Endocrinology and Metabolism , v. 100, p. 920-933, 2015.

• WERNECK DE CASTRO, JOAO PEDRO ; FONSECA, TATIANA L. ; UETA, CINTIA B. ; MCANINCH, ELIZABETH A. ; ABDALLA, SHERINE ; WITTMANN, GABOR ; Lechan, Ronald M. ; GEREBEN, BALAZS ; Bianco, Antonio C. . Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. The Journal of Clinical Investigation , v. 125, p. 769, 2015.

• MCANINCH, ELIZABETH A ; Bianco, Antonio C . Of rats and men: thyroid homeostasis in rodents and human beings - Authors' reply. LANCET DIABETES ENDO , v. 3, p. 933, 2015.

• FONSECA, TATIANA L. ; FERNANDES, GUSTAVO W. ; MCANINCH, ELIZABETH A. ; BOCCO, BARBARA M. L. C. ; ABDALLA, SHERINE M. ; Ribeiro, Miriam O. ; MOHÁCSIK, PETRA ; FEKETE, CSABA ; LI, DAOFENG ; XING, XIAOYUN ; WANG, TING ; Gereben, Balázs ; Bianco, Antonio C. . Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proceedings of the National Academy of Sciences of the United States of America , v. 112, p. 14018-14023, 2015.

• LARTEY, LATTOYA J. ; WERNECK-DE-CASTRO, JOAO PEDRO ; O-SULLIVAN, INSUG ; UNTERMAN, TERRY G. ; Bianco, Antonio C. . Coupling Between Nutrient Availability and Thyroid Hormone Activation. The Journal of Biological Chemistry (Print) , v. 290, p. jbc.M115.665505, 2015.

• Gereben, Balázs ; MCANINCH, ELIZABETH A. ; Ribeiro, Miriam O. ; Bianco, Antonio C. . Scope and limitations of iodothyronine deiodinases in hypothyroidism. Nature Reviews. Endocrinology (Print) , v. 11, p. 642, 2015.

• MCANINCH, ELIZABETH A ; Bianco, Antonio C . New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism. LANCET DIABETES ENDO , v. 3, p. 756-758, 2015.

• WERNECK-DE-CASTRO, JOAO P. ; FONSECA, TATIANA L. ; IGNACIO, DANIELE L. ; FERNANDES, GUSTAVO W. ; ANDRADE-FERAUD, CRISTINA M. ; LARTEY, LATTOYA J. ; RIBEIRO, MARCELO B. ; Ribeiro, Miriam O. ; GEREBEN, BALAZS ; Bianco, Antonio C. . Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes. Endocrinology (Philadelphia) , v. 156, p. 3842-3852, 2015.

• FLIERS, ERIC ; Bianco, Antonio C ; LANGOUCHE, LIES ; BOELEN, ANITA . Thyroid function in critically ill patients. LANCET DIABETES ENDO , v. 3, p. 816-825, 2015.

• ROBERTS, SIMON C. ; Bianco, Antonio C. ; STAPLETON, HEATHER M. . Disruption of Type 2 Iodothyronine Deiodinase Activity in Cultured Human Glial Cells by Polybrominated Diphenyl Ethers. Chemical Research in Toxicology , v. 28, p. 1265-1274, 2015.

• MCANINCH, ELIZABETH A. ; FONSECA, TATIANA L. ; POGGIOLI, RAFFAELLA ; PANOS, ANTHONY L. ; SALERNO, TOMAS A. ; DENG, YOUPING ; LI, YAN ; Bianco, Antonio C. ; IACOBELLIS, GIANLUCA . Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease. Obesity (Silver Spring, Md.) , v. 23, p. 1267-1278, 2015.

• CAO, YENONG ; GOMES, SAMIRAH A. ; RANGEL, ERIKA B. ; PAULINO, ELLENA C. ; FONSECA, TATIANA L. ; LI, JINLIANG ; TEIXEIRA, MARILIA B. ; GOUVEIA, CECILIA H. ; Bianco, Antonio C. ; KAPILOFF, MICHAEL S. ; BALKAN, WAYNE ; HARE, JOSHUA M. . S-nitrosoglutathione reductase-dependent PPAR denitrosylation participates in MSC-derived adipogenesis and osteogenesis. The Journal of Clinical Investigation , v. 124, p. 1679, 2015.

• Bianco, Antonio C. ; ANDERSON, GRANT ; FORREST, DOUGLAS ; GALTON, VALERIE ANNE ; Gereben, Balázs ; KIM, BRIAN W. ; KOPP, PETER A. ; LIAO, XIAO HUI ; OBREGON, MARIA JESUS ; PEETERS, ROBIN P. ; REFETOFF, SAMUEL ; SHARLIN, DAVID S. ; SIMONIDES, WARNER S. ; WEISS, ROY E. ; WILLIAMS, GRAHAM R. . American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models. Thyroid (New York, N.Y.) , v. 24, p. 88-168, 2014.

• FONSECA, T. L. ; WERNECK-DE-CASTRO, J. P. ; Castillo, M. ; BOCCO, B. M. L. C. ; FERNANDES, G. W. ; MCANINCH, E. A. ; IGNACIO, D. L. ; MOISES, C. C. S. ; FERREIRA, A. ; GEREBEN, B. ; BIANCO, A. C. . Tissue-Specific Inactivation of Type 2 Deiodinase Reveals Multilevel Control of Fatty Acid Oxidation by Thyroid Hormone in the Mouse. Diabetes (New York, N.Y.) , v. 63, p. 1594-1604, 2014.

• LEIVA, ANGEL G ; CHEN, ANNE L ; DEVARAJAN, PRIYADHARSHINI ; CHEN, ZHIBIN ; DAMANPOUR, SHADI ; HALL, JESSICA A ; Bianco, Antonio C ; LI, JIE ; BADIAVAS, EVANGELOS V ; ZAIAS, JULIA ; MITEVA, MARIYA ; ROMANELLI, PAOLO ; NOURI, KEYVAN ; CAO WIKRAMANAYAKE, TONGYU . Loss of Mpzl3 Function Causes Various Skin Abnormalities and Greatly Reduced Adipose Depots. Journal of Investigative Dermatology , v. 134, p. 1817-1827, 2014.

• MCANINCH, ELIZABETH A. ; Bianco, Antonio C. . Thyroid hormone signaling in energy homeostasis and energy metabolism. Annals of the New York Academy of Sciences , v. 1311, p. 77-87, 2014.

• FERNANDES, G. W. ; Ueta, C. B. ; FONSECA, T. L. ; GOUVEIA, C. H. A. ; LANCELLOTTI, C. L. ; BRUM, P. C. ; CHRISTOFFOLETE, M. A. ; BIANCO, A. C. ; RIBEIRO, M. O. . Inactivation of the adrenergic receptor 2 disrupts glucose homeostasis in mice. Journal of Endocrinology , v. 221, p. 381-390, 2014.

• MEDINA, MAYRIN C. ; FONESCA, TATIANA L. ; MOLINA, JUDITH ; FACHADO, ALBERTO ; Castillo, Melany ; DONG, LIPING ; SOARES, RENATA ; HERNÁNDEZ, ARTURO ; CAICEDO, ALEJANDRO ; Bianco, Antonio C. . Maternal Inheritance of an Inactive Type III Deiodinase Gene Allele Affects Mouse Pancreatic -Cells and Disrupts Glucose Homeostasis. Endocrinology (Philadelphia) , v. 155, p. 3160-3171, 2014.

• ABDALLA, SHERINE M. ; Bianco, Antonio C. . Defending plasma T3 is a biological priority. Clinical Endocrinology (Oxford. Print) , v. 81, p. 633-641, 2014.

• FONSECA, TATIANA L. ; CORREA-MEDINA, MAYRIN ; CAMPOS, MAIRA P.O. ; WITTMANN, GABOR ; WERNECK-DE-CASTRO, JOAO P. ; Drigo, Rafael Arrojo e ; MORA-GARZON, MAGDA ; UETA, CINTIA BAGNE ; CAICEDO, ALEJANDRO ; FEKETE, CSABA ; GEREBEN, BALAZS ; Lechan, Ronald M. ; Bianco, Antonio C. . Coordination of hypothalamic and pituitary T3 production regulates TSH expression. The Journal of Clinical Investigation , v. 4, p. 1492, 2013.

• HONG, E.-G. ; KIM, B. W. ; YOUNG JUNG, D. ; HUN KIM, J. ; YU, T. ; SEIXAS DA SILVA, W. ; FRIEDLINE, R. H. ; BIANCO, S. D. ; SESLAR, S. P. ; WAKIMOTO, H. ; BERUL, C. I. ; RUSSELL, K. S. ; WON LEE, K. ; LARSEN, P. R. ; BIANCO, A. C. ; KIM, J. K. . Cardiac Expression of Human Type 2 Iodothyronine Deiodinase Increases Glucose Metabolism and Protects Against Doxorubicin-Induced Cardiac Dysfunction in Male Mice. Endocrinology (Philadelphia) , v. 10, p. 3937, 2013.

• VOSE, L. R. ; VINUKONDA, G. ; JO, S. ; MIRY, O. ; DIAMOND, D. ; KORUMILLI, R. ; ARSHAD, A. ; ZIA, M. T. K. ; HU, F. ; KAYTON, R. J. ; LA GAMMA, E. F. ; BANSAL, R. ; BIANCO, A. C. ; BALLABH, P. . Treatment with Thyroxine Restores Myelination and Clinical Recovery after Intraventricular Hemorrhage. The Journal of Neuroscience , v. 33, p. 17232-17246, 2013.

• Arrojo e Drigo, Rafael ; Egri, Péter ; Jo, Sungro ; Gereben, Balázs ; Bianco, Antonio C. . The Type II Deiodinase Is Retrotranslocated to the Cytoplasm and Proteasomes via p97/Atx3 Complex. Molecular Endocrinology (Baltimore, Md.) , v. 27, p. 2105-2115, 2013.

• Bianco, Antonio C ; MCANINCH, ELIZABETH A . The role of thyroid hormone and brown adipose tissue in energy homoeostasis. The Lancet Diabetes & Endocrinology , v. 1, p. 250-258, 2013.

• POGGIOLI, RAFFAELLA ; UETA, CINTIA B. ; E DRIGO, RAFAEL ARROJO ; Castillo, Melany ; FONSECA, TATIANA L. ; Bianco, Antonio C. . Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice. Obesity (Silver Spring, Md.) , v. n/a, p. n/a-n/a, 2013.

• Arrojo e Drigo, Rafael ; FONSECA, TATIANA L. ; WERNECK-DE-CASTRO, JOAO PEDRO SAAR ; Bianco, Antonio C. . Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochimica et Biophysica Acta. G, General Subjects (Print) , v. 7, p. 3956, 2012.

• Bianco, Antonio C. ; CASULA, SABINA . Thyroid Hormone Replacement Therapy: Three ?Simple? Questions, Complex Answers. European Thyroid Journal , v. 1, p. 88-98, 2012.

• JO, S. ; KALLO, I. ; BARDOCZI, Z. ; Arrojo e Drigo, R. ; ZEOLD, A. ; LIPOSITS, Z. ; OLIVA, A. ; LEMMON, V. P. ; BIXBY, J. L. ; GEREBEN, B. ; BIANCO, A. C. . Neuronal Hypoxia Induces Hsp40-Mediated Nuclear Import of Type 3 Deiodinase As an Adaptive Mechanism to Reduce Cellular Metabolism. The Journal of Neuroscience , v. 32, p. 8491-8500, 2012.

• Kalló, Imre ; MOHÁCSIK, PETRA ; VIDA, BARBARA ; Zeöld, Anikó ; BARDÓCZI, ZSUZSANNA ; Zavacki, Ann Marie ; FARKAS, ERZSÉBET ; KÁDÁR, ANDREA ; HRABOVSZKY, ERIK ; Arrojo e Drigo, Rafael ; DONG, LIPING ; BARNA, LÁSZLÓ ; PALKOVITS, MIKLÓS ; BORSAY, BEÁTA A. ; HERCZEG, LÁSZLÓ ; Lechan, Ronald M. ; Bianco, Antonio C. ; Liposits, Zsolt ; FEKETE, CSABA ; Gereben, Balázs . A Novel Pathway Regulates Thyroid Hormone Availability in Rat and Human Hypothalamic Neurosecretory Neurons. Plos One , v. 7, p. e37860, 2012.

• CASULA, SABINA ; Bianco, Antonio C. . Thyroid Hormone Deiodinases and Cancer. Frontiers in Endocrinology , v. 3, p. 74, 2012.

• Ueta, C. B. ; OSKOUEI, B. N. ; OLIVARES, E. L. ; PINTO, J. R. ; CORREA, M. M. ; Simovic, G. ; SIMONIDES, W. S. ; HARE, J. M. ; BIANCO, A. C. . Absence of Myocardial Thyroid Hormone Inactivating Deiodinase Results in Restrictive Cardiomyopathy in Mice. Molecular Endocrinology (Baltimore, Md.) , v. 26, p. 809-818, 2012.

• Ueta, C. B. ; FERNANDES, G. W. ; CAPELO, L. P. ; FONSECA, T. L. ; MACULAN, F. D. ; GOUVEIA, C. H. A. ; BRUM, P. C. ; CHRISTOFFOLETE, M. A. ; AOKI, M. S. ; LANCELLOTTI, C. L. ; KIM, B. ; BIANCO, A. C. ; RIBEIRO, M. O. . 1 Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice. Journal of Endocrinology , v. 214, p. 359-365, 2012.

• da-Silva, Wagner S. ; Ribich, Scott ; Drigo, Rafael Arrojo e ; Castillo, Melany ; Patti, Mary-Elizabeth ; Bianco, Antonio C. . The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Letters (Print) , v. 585, p. 539-544, 2011.

• RIBEIRO, M. O. ; BIANCO, A. C. . Crossing the Hurdles of Thyroid Hormone Receptor- Activation. Endocrinology (Philadelphia) , v. 152, p. 745-747, 2011.

• Castillo, M. ; Hall, J. A. ; Correa-Medina, M. ; Ueta, C. ; Won Kang, H. ; Cohen, D. E. ; BIANCO, A. C. . Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality. Diabetes (New York, N.Y.) , v. 60, p. 1082-1089, 2011.

• Arrojo e Drigo, Rafael ; Bianco, Antonio C. . Type 2 deiodinase at the crossroads of thyroid hormone action. International Journal of Biochemistry & Cell Biology , v. -, p. -, 2011.

• BIANCO, A. C. . Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling. Endocrinology (Philadelphia) , v. -, p. -, 2011.

• Ueta, C. B. ; OLIVARES, E. L. ; BIANCO, A. C. . Responsiveness to Thyroid Hormone and to Ambient Temperature Underlies Differences Between Brown Adipose Tissue and Skeletal Muscle Thermogenesis in a Mouse Model of Diet-Induced Obesity. Endocrinology (Philadelphia) , v. 152, p. 3571, 2011.

• Medina, M. C. ; Molina, J. ; Gadea, Y. ; Fachado, A. ; Murillo, M. ; Simovic, G. ; Pileggi, A. ; Hernandez, A. ; Edlund, H. ; BIANCO, A. C. . The Thyroid Hormone-Inactivating Type III Deiodinase Is Expressed in Mouse and Human -Cells and Its Targeted Inactivation Impairs Insulin Secretion. Endocrinology (Philadelphia) , v. -, p. -, 2011.

• Arrojo e Drigo, R. ; FONSECA, T. L. ; Castillo, M. ; SALATHE, M. ; Simovic, G. ; MOHACSIK, P. ; GEREBEN, B. ; BIANCO, A. C. . Endoplasmic Reticulum Stress Decreases Intracellular Thyroid Hormone Activation via an eIF2a-Mediated Decrease in Type 2 Deiodinase Synthesis. Molecular Endocrinology (Baltimore, Md.) , v. 25, p. 2065-2075, 2011.

• MOHÁCSIK, PETRA ; Zeöld, Anikó ; Bianco, Antonio C. ; Gereben, Balázs . Thyroid Hormone and the Neuroglia: Both Source and Target. Journal of Thyroid Research , v. 2011, p. 1-16, 2011.

• IACOBELLIS, GIANLUCA ; Bianco, Antonio C. . Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends in Endocrinology and Metabolism , v. 22, p. 450-457, 2011.

• Castillo, Melany ; Freitas, Beatriz C.G. ; Rosene, Matthew L. ; Drigo, Rafael A. ; Grozovsky, Renata ; Maciel, Rui M.B. ; Patti, Mary Elizabeth ; Ribeiro, Miriam O. ; Bianco, Antonio C. . Impaired Metabolic Effects of a Thyroid Hormone Receptor Beta-Selective Agonist in a Mouse Model of Diet-Induced Obesity. Thyroid (New York, N.Y.) , v. 20, p. 545-553, 2010.

• CHRISTOFFOLETE, M. A. ; DOLESCHALL, M. ; Egri, P. ; LIPOSITS, Z. ; ZAVACKI, A. M. ; BIANCO, A. C. ; GEREBEN, B. . Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway. Journal of Endocrinology , v. 205, p. 179-186, 2010.

• Acosta, Brenda M ; Bianco, Antonio C . New insights into thyroid hormone replacement therapy. F1000 medicine reports , v. 2, p. 34, 2010.

• Freitas, Beatriz C.G. ; Gereben, Balázs ; Castillo, Melany ; Kalló, Imre ; Zeöld, Anikó ; Egri, Péter ; Liposits, Zsolt ; Zavacki, Ann Marie ; Maciel, Rui M.B. ; Jo, Sungro ; Singru, Praful ; Sanchez, Edith ; Lechan, Ronald M. ; Bianco, Antonio C. . Paracrine signaling by glial cellderived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. The Journal of Clinical Investigation , v. 120, p. 2206-2217, 2010.

• Hall, J. A. ; RIBICH, S. ; CHRISTOFFOLETE, M. A. ; Simovic, G. ; Correa-Medina, M. ; PATTI, M. E. ; BIANCO, A. C. . Absence of Thyroid Hormone Activation during Development Underlies a Permanent Defect in Adaptive Thermogenesis. Endocrinology (Philadelphia) , v. 151, p. 4573-4582, 2010.

• ROSENE, M. L. ; WITTMANN, G. ; Arrojo e Drigo, R. ; SINGRU, P. S. ; LECHAN, R. M. ; BIANCO, A. C. . Inhibition of the Type 2 Iodothyronine Deiodinase Underlies the Elevated Plasma TSH Associated with Amiodarone Treatment. Endocrinology (Philadelphia) , v. 151, p. 5961-5970, 2010.

• Streijger, Femke ; Pluk, Helma ; Oerlemans, Frank ; Beckers, Gaby ; Bianco, Antonio C. ; Ribeiro, Miriam O. ; Wieringa, Bé ; Van der Zee, Catharina E.E.M. . Mice lacking brain-type creatine kinase activity show defective thermoregulation. Physiology & Behavior , v. 97, p. 76-86, 2009.

• KIM, B. W. ; BIANCO, A. C. . For Some, L-Thyroxine Replacement Might Not Be Enough: A Genetic Rationale. The Journal of Clinical Endocrinology and Metabolism , v. 94, p. 1521-1523, 2009.

• Hall, J. A. ; BIANCO, A. C. . Triumphs of the Thyroid Despite Lesser Conversion. Endocrinology (Philadelphia) , v. 150, p. 2502-2504, 2009.

• Patti, Mary-Elizabeth ; Houten, Sander M. ; Bianco, Antonio C. ; Bernier, Raquel ; Larsen, P. Reed ; Holst, Jens J. ; Badman, Michael K. ; Maratos-Flier, Eleftheria ; Mun, Edward C. ; Pihlajamaki, Jussi ; Auwerx, Johan ; Goldfine, Allison B. . Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism. Obesity (Silver Spring, Md.) , v. 17, p. 1671-1677, 2009.

• Pihlajamaki, J. ; Boes, T. ; Kim, E.-Y. ; DEARIE, F. ; KIM, B. W. ; Schroeder, J. ; Mun, E. ; Nasser, I. ; Park, P. J. ; BIANCO, A. C. ; Goldfine, A. B. ; PATTI, M. E. . Thyroid Hormone-Related Regulation of Gene Expression in Human Fatty Liver. The Journal of Clinical Endocrinology and Metabolism , v. 94, p. 3521-3529, 2009.

• Gereben, Balázs ; Bianco, Antonio C. . Covering the Base-Pairs in Iodothyronine Deiodinase-1 Biology: Holes Remain in the Lineup. Thyroid (New York, N.Y.) , v. 19, p. 1027-1029, 2009.

• ZAVACKI, A. M. ; Arrojo e Drigo, R. ; FREITAS, B. C. G. ; Chung, M. ; HARNEY, J. W. ; Egri, P. ; WITTMANN, G. ; FEKETE, C. ; GEREBEN, B. ; BIANCO, A. C. . The E3 Ubiquitin Ligase TEB4 Mediates Degradation of Type 2 Iodothyronine Deiodinase. Molecular and Cellular Biology (Print) , v. 29, p. 5339-5347, 2009.

• Won Kang, H. ; RIBICH, S. ; KIM, B. W. ; Hagen, S. J. ; BIANCO, A. C. ; Cohen, D. E. . Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. Journal of Lipid Research (Print) , v. 50, p. 2212-2221, 2009.

• Amorim, B. S ; Ueta, C. B ; Freitas, B. C G ; Nassif, R. J ; Gouveia, C. H. d. A. ; Christoffolete, M. A ; Moriscot, A. S ; Lancelloti, C. L. ; Llimona, F. ; Barbeiro, H. V. ; Possolo de Souza, H. ; Catanozi, S. ; PASSARELLI, M. ; Aoki, M. S ; Bianco, A. C ; Ribeiro, M. O . A TR-selective agonist confers resistance to diet-induced obesity. Journal of Endocrinology , v. 203, p. 291-299, 2009.

• RIBEIRO, M. O. ; BIANCO, S. D. C. ; Kaneshige, M. ; SCHULTZ, J. J. ; Cheng, S.-y. ; BIANCO, A. C. ; BRENT, G. A. . Expression of Uncoupling Protein 1 in Mouse Brown Adipose Tissue Is Thyroid Hormone Receptor- Isoform Specific and Required for Adaptive Thermogenesis. Endocrinology (Philadelphia) , v. 151, p. 432-440, 2009.

• GROZOVSKY, R. ; RIBICH, S. ; ROSENE, M. L. ; MULCAHEY, M. A. ; HUANG, S. A. ; PATTI, M. E. ; BIANCO, A. C. ; KIM, B. W. . Type 2 deiodinase expression is induced by PPAR- agonists in skeletal myocytes. Endocrinology (Philadelphia) , v. 150, p. 1-18, 2008.

• GEREBEN, B. ; ZAVACKI, A. M. ; RIBICH, S. ; KIM, B. W. ; HUANG, S. A. ; SIMONIDES, W. S. ; ZEOLD, A. ; BIANCO, A. C. . Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling. Endocrine Reviews , v. 29, p. 898-938, 2008.

• CAPELO, L. P. ; BEBER, E. H. ; HUANG, S. A. ; ZORN, T. M. T. ; BIANCO, A. C. ; GOUVEIA, C. H. A. . Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton. Bone (New York) , v. 43, p. 921-930, 2008.

• SANCHEZ, E. ; SINGRU, P. S. ; ACHARYA, R. ; BODRIA, M. ; FEKETE, C. ; ZAVACKI, A. M. ; BIANCO, A. C. ; LECHAN, R. M. . Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus.. Endocrinology (Philadelphia) , v. 149, p. 4329-4335, 2008.

• SAGAR, G. D. V. ; GEREBEN, B. ; CALLEBAUT, I. ; MORNON, J. ; ZEOLD, A. ; CURCIO-MORELLI, C. ; HARNEY, J. W. ; LUONGO, C. ; MULCAHEY, M. A. ; LARSEN, P. R. ; HUANG, S. A. ; BIANCO, A. C. . The thyroid hormone-inactivating deiodinase functions as a homodimer.. Molecular Endocrinology (Baltimore) , v. 22, p. 1382-1393, 2008.

• BIANCO, A. C. . Metabolic effects of thyroid hormones-beyond traditional prospects.. Thyroid (New York) , v. 18, p. 99-100, 2008.

• SIMONIDES, W. S. ; MULCAHEY, M. A. ; REDOUT, E. M. ; MULLER, A. ; ZUIDWIJK, M. J. ; VISSER, T. J. ; WASSEN, F. W. J. S. ; CRESCENZI, A. ; SILVA, W. S. ; HARNEY, J. ; ENGEL, F. B. ; OBREGON, M. ; LARSEN, P. R. ; BIANCO, A. C. ; HUANG, S. A. . Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.. Journal of Clinical Investigation , v. 118, p. 975-983, 2008.

• HUANG, S. A. ; BIANCO, A. C. . Reawakened interest in type III iodothyronine deiodinase in critical illness and injury.. Nature Clinical Practice Endocrinology & Metabolism , v. 4, p. 148-155, 2008.

• ADAMS, B. A. ; GRAY, S. L. ; ISAAC, E. R. ; BIANCO, A. C. ; VIDAL-PUIG, A. J. ; SHERWOOD, N. M. . Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide.. Endocrinology (Philadelphia) , v. 149, p. 1571-1580, 2008.

• GEREBEN, B. ; ZEOLD, A. ; DENTICE, M. ; SALVATORE, D. ; BIANCO, A. C. . Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences.. Cellular and Molecular Life Sciences , v. 65, p. 570-590, 2008.

• DENTICE, M. ; LUONGO, C. ; HUANG, S. A. ; AMBROSIO, R. ; ELEFANTE, A. ; MIREBEAU-PRUNIER, D. ; ZAVACKI, A. M. ; FENZI, G. ; GRACHTCHOUK, M. ; HUTCHIN, M. ; DLUGOSZ, A. A. ; BIANCO, A. C. ; MISSERO, C. ; LARSEN, P. R. ; SALVATORE, D. . Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.. Proceedings of the National Academy of Sciences of the United States of America , v. 104, p. 14466-14471, 2007.

• OLIVARES, E. L. ; MARASSI, M. P. ; FORTUNATO, R. S. ; SILVA, A. C. M. ; COSTA-E-SOUSA, R. H. ; ARAUJO, I. G. ; MATTOS, E. C. ; MASUDA, M. O. ; MULCAHEY, M. A. ; HUANG, S. A. ; BIANCO, A. C. ; CARVALHO, D. P. . Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.. Endocrinology (Philadelphia) , v. 148, p. 4786-4792, 2007.

• FEKETE, C. ; FREITAS, B. C. G. ; ZEOLD, A. ; WITTMANN, G. ; KADAR, A. ; LIPOSITS, Z. ; CHRISTOFFOLETE, M. A. ; SINGRU, P. ; LECHAN, R. M. ; BIANCO, A. C. ; GEREBEN, B. . Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.. Endocrinology (Philadelphia) , v. 148, p. 4865-4874, 2007.

• WAJNER, S. M. ; WAGNER, M. S. ; MELO, R. C. N. ; PARREIRA, G. G. ; CHIARINI-GARCIA, H. ; BIANCO, A. C. ; FEKETE, C. ; SANCHEZ, E. ; LECHAN, R. M. ; MAIA, A. L. . Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis.. Journal of Endocrinology , v. 194, p. 47-54, 2007.

• BIANCO, A. C. ; RIBICH, S. ; KIM, B. W. . An inside job.. Endocrinology (Philadelphia) , v. 148, p. 3077-3079, 2007.

• SAGAR, G. D. V. ; GEREBEN, B. ; CALLEBAUT, I. ; MORNON, J. ; ZEOLD, A. ; SILVA, W. S. ; LUONGO, C. ; DENTICE, M. ; TENTE, S. M. ; FREITAS, B. C. G. ; HARNEY, J. W. ; ZAVACKI, A. M. ; BIANCO, A. C. . Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.. Molecular and Cellular Biology , v. 27, p. 4774-4783, 2007.

• CRUNKHORN, S. ; DEARIE, F. ; MANTZOROS, C. ; GAMI, H. ; SILVA, W. S. ; ESPINOZA, D. ; FAUCETTE, R. ; BARRY, K. ; BIANCO, A. C. ; PATTI, M. E. . Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.. The Journal of Biological Chemistry , v. 282, p. 15439-15450, 2007.

• SOUZA, S. C. ; CHRISTOFFOLETE, M. A. ; RIBEIRO, M. O. ; MIYOSHI, H. ; STRISSEL, K. J. ; STANCHEVA, Z. S. ; ROGERS, N. H. ; DEON, T. M. ; PERFIELD, J. W. ; IMACHI, H. ; OBIN, M. S. ; BIANCO, A. C. ; GREENBERG, A. S. . Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue.. Journal of Lipid Research , v. 48, p. 1273-1279, 2007.

• VILLICEV, C. M. ; FREITAS, F. R. S. ; AOKI, M. S. ; TAFFAREL, C. ; SCANLAN, T. S. ; MORISCOT, A. S. ; RIBEIRO, M. O. ; BIANCO, A. C. ; GOUVEIA, C. H. A. . Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats.. Journal of Endocrinology , v. 193, p. 21-29, 2007.

• SILVA, W. S. ; HARNEY, J. W. ; KIM, B. W. ; LI, J. ; BIANCO, S. D. C. ; CRESCENZI, A. ; CHRISTOFFOLETE, M. A. ; HUANG, S. A. ; BIANCO, A. C. . The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.. Diabetes (New York) , v. 56, p. 767-776, 2007.

• CHRISTOFFOLETE, M. A. ; DRIGO, R. A. E. ; GAZONI, F. ; TENTE, S. M. ; GONCALVES, V. ; AMORIM, B. S. ; LARSEN, P. R. ; BIANCO, A. C. ; ZAVACKI, A. M. . Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations.. Endocrinology (Philadelphia) , v. 48, p. 954-960, 2007.

• BIANCO, A. C. ; KIM, B. W. . Deiodinases: implications of the local control of thyroid hormone action. Journal of Clinical Investigation , v. 116, p. 2571-2579, 2006.

• ZEOLD, A. ; PORMULLER, L. ; DENTICE, M. ; HARNEY, J. W. ; CURCIO-MORELLI, C. ; TENTE, S. M. ; BIANCO, A. C. ; GEREBEN, B. . Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization.. The Journal of Biological Chemistry , v. 281, p. 31543-31543, 2006.

• MIYOSHI, H. ; SOUZA, S. C. ; ZHANG, H. ; STRISSEL, K. J. ; CHRISTOFFOLETE, M. A. ; KOVSAN, J. ; RUDICH, A. ; KRAEMER, F. B. ; BIANCO, A. C. ; OBIN, M. S. ; GREENBERG, A. S. . Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms.. The Journal of Biological Chemistry , v. 281, p. 15837-15844, 2006.

• WATANABE, M. ; HOUTEN, S. M. ; MATAKI, C. ; CHRISTOFFOLETE, M. A. ; KIM, B. W. ; SATO, H. ; MESSADDEQ, N. ; HARNEY, J. W. ; EZAKI, O. ; KODAMA, T. ; SCHOONJANS, K. ; BIANCO, A. C. ; AUWERX, J. . Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.. Nature (London) , v. 439, p. 484-489, 2006.

• ZEOLD, A. ; DOLESCHALL, M. ; HAFFNER, M. C. ; CAPELO, L. P. ; MENYHERT, J. ; LIPOSITS, Z. ; SILVA, W. S. ; BIANCO, A. C. ; KACSKOVICS, I. ; FEKETE, C. ; GEREBEN, B. . Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene. Endocrinology (Philadelphia) , v. 147, p. 4419-4429, 2006.

• CHRISTOFFOLETE, M. A. ; RIBEIRO, R. ; SINGRU, P. ; FEKETE, C. ; SILVA, W. S. ; GORDON, D. F. ; HUANG, S. A. ; CRESCENZI, A. ; HARNEY, J. W. ; RIDGWAY, E. C. ; LARSEN, P. R. ; BIANCO, A. C. ; LECHAN, R. M. . Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.. Endocrinology (Philadelphia) , v. 147, p. 1735-1743, 2006.

• SHARMA, V. ; HAYS, W. R. ; WOOD, W. M. ; PUGAZHENTHI, U. ; GERMAIN, D. L. S. ; BIANCO, A. C. ; KREZEL, W. ; CHAMBON, P. ; HAUGEN, B. R. . Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.. Endocrinology (Philadelphia) , v. 147, p. 1431-1451, 2006.

• BIANCO, A. C. ; MAIA, A. L. ; SILVA, W. S. ; CHRISTOFFOLETE, M. A. . Adaptive activation of thyroid hormone and energy expenditure.. Bioscience Reports , v. 25, p. 191-208, 2005.

• FEKETE, C. ; SINGRU, P. S. ; SANCHEZ, E. ; SARKAR, S. ; CHRISTOFFOLETE, M. A. ; RIBERIO, R. S. ; RAND, W. M. ; EMERSON, C. H. ; BIANCO, A. C. ; LECHAN, R. M. . Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus.. Endocrinology (Philadelphia) , v. 147, p. 520-529, 2005.

• BIANCO, A. C. ; LARSEN, P. R. . Cellular and structural biology of the deiodinases.. Thyroid (New York) , v. 15, p. 777-786, 2005.

• FEKETE, C. ; SARKAR, S. ; CHRISTOFFOLETE, M. A. ; EMERSON, C. H. ; BIANCO, A. C. ; LECHAN, R. M. . Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels.. Brain Research , v. 1056, p. 97-99, 2005.

• KALAANY, N. Y. ; GAUTHIER, K. C. ; ZAVACKI, A. M. ; MAMMEN, P. P. A. ; KITAZUME, T. ; PETERSON, J. A. ; HORTON, J. D. ; GARRY, D. J. ; BIANCO, A. C. ; MANGELSDORF, D. J. . LXRs regulate the balance between fat storage and oxidation. Cell Metabolism , v. 1, p. 231-244, 2005.

• DENTICE, M. ; BANDYOPADHYAY, A. ; GEREBEN, B. ; CALLEBAUT, I. ; CHRISTOFFOLETE, M. A. ; KIM, B. W. ; NISSIM, S. ; MORNON, J. ; ZAVACKI, A. M. ; ZEOLD, A. ; CAPELO, L. P. ; CURCIO-MORELLI, C. ; RIBEIRO, R. ; HARNEY, J. W. ; TABIN, C. J. ; BIANCO, A. C. . The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.. Nature Cell Biology , v. 7, p. 698-705, 2005.

• CANANI, L. H. ; CAPP, C. ; DORA, J. M. ; MEYER, E. L. S. ; WAGNER, M. S. ; HARNEY, J. W. ; LARSEN, P. R. ; GROSS, J. L. ; BIANCO, A. C. ; MAIA, A. L. . The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.. The Journal of Clinical Endocrinology and Metabolism , v. 90, p. 3472-3478, 2005.

• ZAVACKI, A. M. ; YING, H. ; CHRISTOFFOLETE, M. A. ; AERTS, G. ; SO, E. ; HARNEY, J. W. ; CHENG, S. ; LARSEN, P. R. ; BIANCO, A. C. . Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.. Endocrinology (Philadelphia) , v. 146, p. 1568-1575, 2005.

• GOUVEIA, C. H. A. ; CHRISTOFFOLETE, M. A. ; ZAITUNE, C. R. ; DORA, J. M. ; HARNEY, J. W. ; MAIA, A. L. ; BIANCO, A. C. . Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation.. Endocrinology (Philadelphia) , v. 146, p. 195-200, 2005.

• MONTE, O. ; ZYNGIER, S. ; KIMURA, E. T. ; BIANCO, A. C. . Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-walker mammary carcinoma. Arquivos Brasileiros de Endocrinologia & Metabologia , v. 49, p. 253-264, 2005.

• BIANCO, A. C. . Impact factor. The editor's report?. Arquivos Brasileiros de Endocrinologia & Metabologia , v. 48, p. 335-336, 2004.

• BIANCO, A. C. . Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects.. Arquivos Brasileiros de Endocrinologia & Metabologia , v. 48, p. 16-24, 2004.

• BIANCO, S. D. C. ; KIM, B. W. ; ZHANG, J. X. ; HARNEY, J. W. ; RIBEIRO, R. ; GEREBEN, B. ; BIANCO, A. C. ; MENDE, U. ; LARSEN, P. R. . Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.. Molecular Endocrinology (Baltimore) , v. 18, p. 1840-1849, 2004.

• CHRISTOFFOLETE, M. A. ; LINARDI, C. C. G. ; JESUS, L. ; EBINA, K. N. ; BIANCO, S. D. C. ; RIBEIRO, M. O. ; RABELO, R. ; CURCIO-MORELLI, C. ; MARTINS, L. ; KIMURA, E. T. ; BIANCO, A. C. . Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis.. Diabetes (New York) , v. 53, p. 577-584, 2004.

• FEKETE, C. ; GEREBEN, B. ; DOLESCHALL, M. ; HARNEY, J. W. ; DORA, J. M. ; BIANCO, A. C. ; SARKAR, S. ; LIPOSITS, Z. ; RAND, W. ; EMERSON, C. ; KACSKOVICS, I. ; LARSEN, P. R. ; LECHAN, R. M. . Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome.. Endocrinology (Philadelphia) , v. 145, p. 1649-1655, 2004.

• FREITAS, F. R. S. ; MORISCOT, A. S. ; JORGETTI, V. ; SOARES, A. G. ; PASSARELLI, M. ; SCANLAN, T. S. ; BRENT, G. A. ; BIANCO, A. C. ; GOUVEIA, C. H. A. . Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1.. American Journal of Physiology. Endocrinology and Metabolism , v. 185, p. 1135-1141, 2003.

• KIM, B. W. ; ZAVACKI, A. M. ; CURCIO-MORELLI, C. ; Dentice, M. ; HARNEY, J. W. ; LARSEN, P. R. ; BIANCO, A. C. . Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.. Molecular Endocrinology (Baltimore) , v. 17, p. 2603-2612, 2003.

• Nakayama A ; BIANCO, A. C. ; Zhang C-Y ; Lowel BB ; Frangioni JV . Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging.. MOL IMAGING , v. 2, p. 37-49, 2003.

• CURCIO-MORELLI, C. ; ZAVACKI, A. M. ; CHRISTOFFOLETE, M. A. ; GEREBEN, B. ; FREITAS, B. C. G. ; HARNEY, J. W. ; LI, Z. ; WU, G. ; BIANCO, A. C. . Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.. Journal of Clinical Investigation , v. 112, p. 189-196, 2003.

• CURCIO-MORELLI, C. ; GEREBEN, B. ; ZAVACKI, A. M. ; KIM, B. W. ; HUANG, S. A. ; HARNEY, J. W. ; LARSEN, P. R. ; BIANCO, A. C. . In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases.. Endocrinology (Philadelphia) , v. 144, p. 937-946, 2003.

• FEKETE, C. ; SARKAR, S. ; RAND, W. M. ; HARNEY, J. W. ; EMERSON, C. H. ; BIANCO, A. C. ; BECK-SICKINGER, A. ; LECHAN, R. M. . Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis.. Endocrinology (Philadelphia) , v. 143, p. 4513-4519, 2003.

• BAQUI, M. ; BOTERO, D. ; GEREBEN, B. ; CURCIO-MORELLI, C. ; HARNEY, J. W. ; SALVATORE, D. ; SORIMACHI, K. ; LARSEN, P. R. ; BIANCO, A. C. . Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes.. The Journal of Biological Chemistry , v. 278, p. 1206-1211, 2003.

• CALLEBAUT, I. ; CURCIO-MORELLI, C. ; MORNON, J. ; GEREBEN, B. ; BUETTNER, C. ; HUANG, S. A. ; CASTRO, B. ; FONSECA, T. L. ; HARNEY, J. W. ; LARSEN, P. R. ; BIANCO, A. C. . The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure.. The Journal of Biological Chemistry , v. 278, p. 36887-36896, 2003.

• FEKETE, C. ; SARKAR, S. ; RAND, W. M. ; HARNEY, J. W. ; EMERSON, C. H. ; BIANCO, A. C. ; LECHAN, R. M. . Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.. Endocrinology (Philadelphia) , v. 143, p. 3846-3853, 2002.

• BOTERO, D. ; GEREBEN, B. ; GONCALVES, C. ; JESUS, L. A. ; HARNEY, J. W. ; BIANCO, A. C. . Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase.. Molecular Endocrinology (Baltimore) , v. 16, p. 1999-2007, 2002.

• BACHMAN, E. S. ; DHILLON, H. ; ZHANG, C. ; CINTI, S. ; BIANCO, A. C. ; KOBILKA, B. K. ; LOWELL, B. B. . betaAR signaling required for diet-induced thermogenesis and obesity resistance.. Science , v. 297, p. 843-845, 2002.

• BICUDO, J. E. P. W. ; BIANCO, A. C. ; VIANNA, C. R. . Adaptive thermogenesis in hummingbirds.. Journal of Experimental Biology , v. 205, p. 2267-2273, 2002.

• BIANCO, A. C. ; SALVATORE, D. ; GEREBEN, B. ; BERRY, M. J. ; LARSEN, P. R. . Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.. Endocrine Reviews , v. 23, p. 38-89, 2002.

• CRISTOVAO, F. C. ; BISI, H. ; MENDONCA, B. B. ; BIANCO, A. C. ; BLOISE, W. . Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats.. Thyroid (New York) , v. 12, p. 13-18, 2002.

• JESUS, L. A. ; BIANCO, S. D. C. ; RIBEIRO, M. O. ; SCHNEIDER, M. ; KIM, S. ; HARNEY, J. W. ; LARSEN, P. R. ; BIANCO, A. C. . The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue.. Journal of Clinical Investigation , v. 108, p. 1379-1385, 2001.

• GOUVEIA, C. H. A. ; SCHULTZ, J. J. ; BIANCO, A. C. ; BRENT, G. A. . Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms.. Journal of Endocrinology , v. 170, p. 667-675, 2001.

• RIBEIRO, M. O. ; BIANCO, S. D. C. ; SCHULTZ, J. J. ; CHIELLINI, G. ; SCANLAN, T. S. ; BIANCO, A. C. ; BRENT, G. A. . Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific.. Journal of Clinical Investigation , v. 108, p. 97-105, 2001.

• CURCIO-MORELLI, C. ; BAQUI, M. M. A. ; SALVATORE, D. ; RIHN, B. H. ; MOHR, S. ; HARNEY, J. W. ; LARSEN, P. R. ; BIANCO, A. C. . The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.. The Journal of Biological Chemistry , v. 276, p. 30183-30187, 2001.

• PEETERS, R. ; FEKETE, C. ; GONCALVES, C. ; LEGRADI, G. ; TU, H. M. ; HARNEY, J. W. ; BIANCO, A. C. ; LECHAN, R. M. ; LARSEN, P. R. . Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency.. American Journal of Physiology. Endocrinology and Metabolism , v. 281, p. 54-61, 2001.

• VIANNA, C. R. ; HAGEN, T. ; ZHANG, C. ; BACHMAN, E. ; BOSS, O. ; GEREBEN, B. ; MORISCOT, A. S. ; LOWELL, B. B. ; BICUDO, J. E. P. W. ; BIANCO, A. C. . Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.. Physiological Genomics , v. 5, p. 137-145, 2001.

• BAQUI, M. M. A. ; GEREBEN, B. ; HARNEY, J. W. ; LARSEN, P. R. ; BIANCO, A. C. . Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy.. Endocrinology (Philadelphia) , v. 141, p. 4309-4312, 2001.

• GEREBEN, B. ; GONCALVES, C. ; HARNEY, J. W. ; LARSEN, P. R. ; BIANCO, A. C. . Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.. Molecular Endocrinology (Baltimore) , v. 14, p. 1697-1708, 2001.

• RIBEIRO, M. O. ; LEBRUN, F. L. A. S. ; CHRISTOFFOLETE, M. A. ; BRANCO, M. ; CRESCENZI, A. ; BIANCO, S. D. C. ; NEGRAO, N. ; BIANCO, A. C. . Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat.. American Journal of Physiology. Endocrinology and Metabolism , v. 279, p. 314-322, 2001.

• Arnhold, I. J. P. ; OLIVEIRA, S. B. ; OSORIO, M. G. F. ; CARRILHO, A. J. ; NICOLAU, W. ; BIANCO, A. C. ; MENDONCA, B. B. . Lack of reduction in body fat after treatment with insulin-like growth factor-I in two children with growth hormone gene deletions.. Journal of Clinical Investigation , v. 23, p. 258-262, 2000.

• STEINSAPIR, J. ; BIANCO, A. C. ; BUETTNER, C. ; HARNEY, J. W. ; LARSEN, P. R. . Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.. Endocrinology (Philadelphia) , v. 141, p. 1127-1135, 2000.

• BIANCO, A. C. ; MALVESTITI, L. F. ; GOUVEIA, C. H. A. ; WEHBA, S. ; LEWIN, S. ; MARONE, M. M. S. . Morphometric dual-energy X-ray absorptiometry of the spine: report of a large series and correlation with axial bone mineral density.. Journal of Bone and Mineral Research , v. 14, p. 1605-1613, 1999.

• CURCIO-MORELLI, C. ; LOPES, A. M. ; RIBEIRO, M. O. ; FRANCOSO, O. A. ; BIANCO, S. D. C. ; LIMA, F. B. ; BIANCO, A. C. ; BICUDO, J. E. P. W. . Development of Compensatory Thermogenesis in Response to Overfeeding in Hypothyroid Rats. Endocrinology (Philadelphia) , v. 140, p. 3438-3443, 1999.

• BRANCO, M. ; RIBEIRO, M. O. ; NEGRAO, N. ; BIANCO, A. C. . 3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity. American Journal of Physiology. Endocrinology and Metabolism , v. 276, p. 179-187, 1999.

• BIANCO, A. C. ; BIANCO, S. D. C. ; CARVALHO, C. R. F. ; RABELO, R. ; MORISCOT, A. S. . Thyroxine 5'-deiodination mediates norepinephrine-induced lipogenesis in dispersed brown adipocytes.. Endocrinology (Philadelphia) , v. 139, p. 571-578, 1998.

• MARONE, M. M. S. ; GOUVEIA, C. H. A. ; LEWIN, S. ; WEHBA, S. ; MALVESTITI, L. F. ; BIANCO, A. C. . Influence of body composition on the bone mass of postmenopausal women.. São Paulo Medical Journal , v. 115, p. 1580-1588, 1997.

• GOUVEIA, C. H. A. ; JORGETTI, V. ; BIANCO, A. C. . Effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats.. Journal of Bone and Mineral Research , v. 12, p. 2098-2107, 1997.

• PESSOA, J. H. L. ; LEWIN, S. ; LONGUI, C. A. ; MENDONCA, B. B. ; BIANCO, A. C. . Bone mineral density: correlation with body weight, height, bone age and insulin-like growth factor.. Jornal de Pediatria , v. 73, p. 259-264, 1997.

• LEWIN, S. ; GOUVEIA, C. H. A. ; MARONE, M. M. S. ; WEHBA, S. ; MALVESTITI, L. F. ; BIANCO, A. C. . Vertebral and femoral bone mineral density of 724 caucasian Brazilian women: influence of age and body weight. Revista da Associação Médica Brasileira , v. 43, p. 127-136, 1997.

• BIANCO, S. D. C. ; BIANCO, A. C. ; SILVA, J. E. . Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity.. Endocrinology (Philadelphia) , v. 137, p. 5519-5529, 1996.

• RIBELA, M. T. C. P. ; BIANCO, A. C. ; BARTOLINI, P. . The use of recombinant human thyrotropin produced by Chinese hamster ovary cells for the preparation of immunoassay reagents.249. The Journal of Clinical Endocrinology and Metabolism , v. 81, p. 249-256, 1996.

• LATRONICO, A. C. ; MENDONCA, B. B. ; BIANCO, A. C. ; VILLARES, S. M. ; LUCON, M. A. ; NICOLAU, W. ; WAJCHENBERG, B. L. . Calcium-dependent protein kinase-C activity in human adrenocortical neoplasms, hyperplastic adrenals, and normal adrenocortical tissue.. The Journal of Clinical Endocrinology and Metabolism , v. 79, p. 736-739, 1994.

• MORISCOT, A. S. ; RABELO, R. ; BIANCO, A. C. . Corticosterone inhibits uncoupling protein gene expression in brown adipose tissue.. American Journal of Physiology. Endocrinology and Metabolism , v. 265, p. 81-87, 1993.

• BIANCO, S. D. C. ; NEGRAO, N. ; BIANCO, A. C. . Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue.. American Journal of Physiology. Endocrinology and Metabolism , v. 264, p. 874-881, 1993.

• BIANCO, A. C. ; KIEFFERS, J. D. ; SILVA, J. E. . Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes.. Endocrinology (Philadelphia) , v. 130, p. 2625-2633, 1992.

• REHNMARK, S. ; BIANCO, A. C. ; KIEFFERS, J. D. ; SILVA, J. E. . Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold.. American Journal of Physiology. Endocrinology and Metabolism , v. 262, p. 58-67, 1992.

• BIANCO, S. D. C. ; KIMURA, E. T. ; BIANCO, A. C. ; SILVA, J. E. . Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold.. Endocrinology (Philadelphia) , v. 128, p. 2149-2159, 1991.

• Dorgan-Neto, V. ; SAAD-JUNIOR, R. ; HELL, N. S. ; BIANCO, A. C. ; SANTO, G. C. ; RASSLAN, S. . Gastrin changes in the gastric antrum G-cells and in serum gastrin levels after 80% jejunoileal resection in rats. Revista Paulista de Medicina , v. 109, p. 71-76, 1991.

• DIAS-JUNIOR, A. A. ; SCALISSI, N. M. ; CORREA, P. H. S. ; BIANCO, A. C. . Basedow-Graves' disease: analysis of various parameters in the prognosis of remission after clinical treatment. Revista Paulista de Medicina , v. 107, p. 69-74, 1989.

• MARONE, M. M. S. ; LEWIN, S. ; BIANCO, A. C. ; CORREA, P. H. S. . Diagnosis of osteoporosis using dual photon densitometry. Revista da Associação Médica Brasileira , v. 35, p. 57-62, 1989.

• BIANCO, A. C. ; SHENG, X. ; SILVA, J. E. . Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis.. The Journal of Biological Chemistry , v. 263, p. 18168-18175, 1988.

• BIANCO, A. C. ; SILVA, J. E. . Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors.. American Journal of Physiology. Endocrinology and Metabolism , v. 255, p. 496-503, 1988.

• SAAD-JUNIOR, R. ; RASSLAN, S. ; BIANCO, A. C. ; DOINE, A. I. ; HELL, N. S. ; MEDEIROS, L. O. . Histologic and histochemical evaluation of the exocrine pancreas in rats subjected to resection or extensive jejunoileal bypass. Revista da Associação Médica Brasileira , v. 34, p. 123-128, 1988.

• BIANCO, A. C. ; SILVA, J. E. . Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue.. Journal of Clinical Investigation , v. 79, p. 295-300, 1987.

• BIANCO, A. C. ; SILVA, J. E. . Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. American Journal of Physiology. Endocrinology and Metabolism , v. 253, p. 255-263, 1987.

• BIANCO, A. C. ; NUNES, M. T. ; HELL, N. S. ; MACIEL, R. M. B. . The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3'-triiodothyronine generation in rats.. Endocrinology (Philadelphia) , v. 120, p. 1033-1038, 1987.

• BIANCO, A. C. ; SILVA, J. E. . Nuclear 3,5,3'-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques.. Endocrinology (Philadelphia) , v. 120, p. 55-62, 1987.

• NUNES, M. T. ; BIANCO, A. C. . Extrathyroidal conversion of thyroxine to 3,5,3'-triiodothyronine in cold-acclimated thyroxine-maintained thyroidectomized rats.. Brazilian Journal of Medical and Biological Research , v. 19, p. 311-318, 1986.

• NUNES, M. T. ; BIANCO, A. C. ; MIGALA, A. ; AGOSTINI, B. ; HASSELBACH, W. . Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles.. Zeitschrift für Naturforschung. C, A Journal of Biosciences , v. 40, p. 726-734, 1985.

• RASSLAN, S. ; QUINTAO, E. C. R. ; SCALISSI, N. M. ; BIANCO, A. C. ; CHAVES, A. F. ; GOLDBERG, A. C. R. K. ; ARAUJO, M. F. . Changes in serum and hepatic lipids after extensive intestinal resection in the rat. Revista da Associação Médica Brasileira , v. 31, p. 111-115, 1985.

• SAAD-JUNIOR, R. ; BIANCO, A. C. ; MINAS, R. M. ; CHAZANAS, J. C. ; OLIVEIRA, A. M. ; HELL, N. S. ; RASSLAN, S. . Metabolic changes in rats subjected to massive intestinal resection or jejunoileal bypass. Revista Paulista de Medicina , v. 103, p. 171-175, 1985.

• BIANCO, A. C. ; MARONE, M. M. S. ; NUNES, M. T. ; SANTO, G. C. ; CORREA, P. H. S. ; MARIGO, C. ; AURIEMO, C. R. . Characterization of the binding of 125I-TSH to its receptor in low-uptake thyroid hyperplasias. Revista Paulista de Medicina , v. 103, p. 176-181, 1985.

• BIANCO, A. C. ; NUNES, M. T. ; MARONE, M. M. S. ; CORREA, P. H. S. . Conversion of thyroxine (T4) to T3 and rT3 in human leucocyte suspension: its application to clinical investigation. Endocrinologia experimentalis , v. 19, p. 53-61, 1985.

• BIANCO, A. C. ; NUNES, M. T. ; MARONE, M. M. S. ; SCALISSI, N. M. ; CORREA, P. H. S. ; DOUGLAS, C. R. . Thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (reverse T3) conversion in human leukocyte suspensions. Study in hyper and hypothyroidism states. Revista Paulista de Medicina , v. 102, p. 61-64, 1984.

• BIANCO, A. C. ; NUNES, M. T. ; DOUGLAS, C. R. . Influence of mast cells on thyroid function.. Endocrinologia experimentalis , v. 17, p. 99-106, 1983.

• BIANCO, A. C. ; NUNES, M. T. ; MARTINS-JUNIOR, O. ; ROESNER, I. ; DOUGLAS, R. A. ; PEREIRA, R. C. ; DOUGLAS, C. R. . Possible mechanism of action of cholesterol enriched diet on the thyroid.. Endocrinologia experimentalis , v. 15, p. 277-285, 1981.

• BIANCO, A. C. ; ANTONIO, C. ; Manual de Fisiologia Endocrina.. SAO PAULO: INSTITUTO DE CIENCIAS PIOMEDICAS/USP, 1990. 00023p .

• BIANCO, A. C. ; ANTONIO, C. ; Manual de Fisiologia Endocrina. SAO PAULO: ICB/USP, 1990. 00013p .

• BIANCO, A. C. ; ANTONIO, C. ; Manual de Fisiologia Endocrina. SAO PAULO: ICB/USP, 1990. 00014p .

• BIANCO, A. C. . Termogenese No Tecido Adiposo Marron: Implicacoes Para A Obesidade. OBESIDADE: NOVA FRONTEIRA METABOLICA.. SAO PAULO: ACHE, 1987, v. , p. 0048-0062.

• ETTLESON, MATTHEW D. ; RAINE, AVA ; BATISTUZZO, ALICE ; BATISTA, SAMUEL P. ; MCANINCH, ELIZABETH ; TEIXEIRA, MARIA CRISTINA T.V. ; JONKLAAS, JACQUELINE ; LAITEERAPONG, NEDA ; Ribeiro, Miriam O. ; Bianco, Antonio C. . Brain Fog in Hypothyroidism: Understanding the Patient’s Perspective. Endocrine Practice , 2021.

• SHAKIR, MOHAMED K M ; BROOKS, DANIEL I ; MCANINCH, ELIZABETH A ; FONSECA, TATIANA DE LOURDES ; MAI, VINH Q ; Bianco, Antonio C ; HOANG, THANH D . Response to Letter to the Editor From Bonnema et al: Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM , 2021.

• DUMITRESCU, ALEXANDRA M. ; HANLON, ERIN C. ; AROSEMENA, MARILYN ; DUCHON, OLGA ; ETTLESON, MATTHEW ; GIURCANU, MIHAI ; Bianco, Antonio C. . Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans. THYROID , 2021.

Projetos de pesquisa

• 2014 - Atual

  PAPEL DA IODOTIRONINA DESIODASE TIPO 3 NO MODELO DE HIPÓXIA-ISQUÊMICA EM CAMUNDONGOS, Descrição: Os hormônios tireoidianos (HT) são fundamentais para a manutenção de diferentes parâmetros fisiológicos e extremamente importantes para o desenvolvimento do SNC. O processo de conversão de T4 em T3, denominado desiodação, é realizado pelas enzimas D1, D2 e D3, as quais possuem a importante função de promover a ativação ou inativação do hormônio tireoidiano segundo as necessidades específicas dos tecidos. A D3 é responsável por evitar a formação de T3 a partir do T4 e sua expressão é pouco detectada após o nascimento. No entanto, em tecidos submetidos a condições fisiopatológicas relacionadas à ocorrência da hipóxia, observase aumento pronunciado da expressão da enzima D3 que pode resultar em hipotireoidismo local. Dessa forma, nossa hipótese contempla a possibilidade de o aumento na expressão da D3 minimize as consequências negativas da diminuição da oferta de oxigênio ao tecido, constituindo um mecanismo protetor. Assim, iremos determinar, por imunohistoquímica, a expressão da D3 e o RNAm, por PCR em tempo real, de genes reconhecidamente regulados pelo T3 no SNC de camundongos selvagens submetidos à hipóxia isquêmica. A fim de compreender se esse efeito de fato protege o SNC, iremos repetir os experimentos em camundongos que não expressam o gene DIO3 neste tecido (HtzKOD3).. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (2) Doutorado: (2) . , Integrantes: Antonio Carlos Bianco - Integrante / Ribeiro, M. O - Coordenador / BOCCO, B. M. L. C. - Integrante / Bruna Pascarelli Pedrico do Nascimento - Integrante / Thaís Terpins Ravache - Integrante / Thiago Gnecco Bueno Gomez - Integrante., Financiador(es): CAPES - Centro Anhanguera de Promoção e Educação Social - Auxílio financeiro.

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