Fanny Tzelepis

possui graduação em Biomedicina pela Universidade de Mogi das Cruzes (2003) , doutorado em Ciencias Biologicas (Microbiologia e Imunologia) pela UNIFESP (2008), atualmente fazendo pos doutorado na McGill University. Tem experiência na área de Imunologia, com ênfase em Imunologia Celular, atuando principalmente no seguinte tema: resposta imune mediada por celulas T CD8+ em infeccoes parasitarias e bacterianas.

Informações coletadas do Lattes em 04/01/2026

Acadêmico

Formação acadêmica

Doutorado em Microbiologia e Imunologia

2004 - 2008

Universidade Federal de São Paulo
Título: Estudo da resposta imune mediada por linfocitos T CD8+ durante a infeccao experimental pelo Trypanosoma cruzi: especificidade, cinetica e mecanismos de imunodominancia
Dr. Mauricio Martins Rodrigues. Bolsista do(a): Fundação de Amparo à Pesquisa do Estado de São Paulo. Palavras-chave: cél T CD8; T.cruzi; resposta imune.Grande área: Ciências Biológicas / Área: Imunologia / Subárea: Imunologia Celular. Grande Área: Ciências Biológicas / Área: Parasitologia / Subárea: Protozoologia de Parasitos.

Graduação em Biomedicina

2000 - 2003

Universidade de Mogi das Cruzes
Orientador: Mauricio Martins Rodrigues
Bolsista do(a): Fundação de Amparo à Pesquisa do Estado de São Paulo.

Pós-doutorado

2012 - 0000

Pós-Doutorado. , McGill University, MCGILL, Canadá.

2008 - 2012

Pós-Doutorado. , University of Ottawa. , Bolsista do(a): Foreign Affairs and International Trade Can. , Grande área: Ciências Biológicas / Área: Imunologia / Subárea: Imunologia Celular.

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Francês

Compreende Pouco, Fala Pouco, Lê Razoavelmente, Escreve Pouco.

Grego

Compreende Bem, Fala Bem, Lê Razoavelmente, Escreve Pouco.

Áreas de atuação

Grande área: Ciências Biológicas / Área: Imunologia / Subárea: Imunologia Celular.

Grande área: Ciências Biológicas / Área: Parasitologia / Subárea: Protozoologia de Parasitos.

Grande área: Ciências Biológicas / Área: Imunologia / Subárea: Imunologia Aplicada.

Participação em eventos

98th Annual Meeting The American Association of Immunologists. Lack of direct antigenic processing results in delayed CD8+T cell response, which fails to control Salmonella typhimurium infection. 2011. (Congresso).

Keystone Symposium - Immunological Mechanisms of Vaccination.Rapid control of a virulent Salmonella typhimurium is governed by the type on antigen presentation and an early CD8 T cells response.. 2010. (Simpósio).

Keystone Symposium - Immunologic Memory and Host Defense.Infection with Trypanosoma cruzi restricts repertoire of parasite specific CD8+ T cells leading to immunodominance.. 2009. (Simpósio).

13th International Congress of Immunology. MHC heterozygosis reduces specific CD8+T cell immune response to Trypanosoma cruzi epitopes: evidence for T cell competition for antigen presenting cells during infection with a human pathogen.. 2007. (Congresso).

XXXIV Annual Meeting on Basic Research in Chagas'Disease and XXIII Annual Meeting of the Brazilian Society of Protozoology. Mechanisms of immunodominance during CD8+ T cells immune responses to Trypanosoma cruzi. 2007. (Congresso).

International Symposium "Molecualr Immunology of Protozoan Infections".Size of infectious dose controls the tempo of Trypanosoma cruzi multiplication and the kinetics of specific CD8+ T cell expansion. 2007. (Simpósio).

XXXI Meeting of the Brazilian Society for Immunology. Size of infectious dose controls the tempo of Trypanosoma cruzi multiplication and the kinetics of specific CD8+ T cell expansion. 2006. (Congresso).

6th International Cell Death Society Symposium.CD8+ cytotoxic T cells in Trypanosoma cruzi infected mice: Kinetics and possible mecanisms of action. 2006. (Simpósio).

I Simpósio Internacional de Citometria de Fluxo. 2006. (Simpósio).

VI São Paulo Research Conference.Size of infectious dose controls the tempo of Trypanosoma cruzi multiplication and the kinetics of specific CD8+ T cell expansion. 2006. (Simpósio).

XXX Meeting of the Brazilian Society of Immunology. Kinetics of the expansion of CD8+ T cells during experimental infection with a human parasite, Trypanosoma cruzi.. 2005. (Congresso).

II São Paulo Research Conference Mechanisms of infection and vaccines.Interferon-g plays a critical role in CpG oligodeoxynucleotide-adjuvanted immunization with recombinant proteins. 2004. (Simpósio).

XXX Annual Meeting on Basic Research in Chagas Disease and XIX Meeting of the Brazilian Society of Protozoology. Role of endogenous interferon-gamma in CPG ODN- or others adjuvants-assisted immunizations using a recombinant malaria vaccine candidate. 2003. (Congresso).

XXX Annual Meeting on Basic Research in Chagas Disease and XIX Meeting of the Brazilian Society of Protozoology. Mapping CD4 T-cell epiotopes within the amastigote surface protein-2 of Tripanosoma cruzi.. 2003. (Congresso).

XXVII Meeting of the Brazilian society of immunology & V International symposium on allergy and clinical immunology. T cell specifity and function during the antibody immune response induced by recombinant proteins representing Plasmodium vivax candidate (MSP119). 2002. (Congresso).

XXVII Meeting of the Brazilian society of immunology & V International symposium on allergy and clinical immunology. Potency and longevity of the immune response to a recombinant protein representing Plasmodium vivax malaria vaccine in different adjuvant formulations. 2002. (Congresso).

10º Simpósio Internacional de Iniciação Científica da USP.T cell specifity and function during the antibody immune response induced by recombinant proteins representing Plasmodium vivax candidate (MSP119). 2002. (Simpósio).

XVII annual meeting of the brazilian society of protozoology. XVII annual meeting of the brazilian society of protozoology. 2001. (Congresso).

Produções bibliográficas

TZELEPIS, FANNY ; ALCON, VALERIA ; DUDANI, RENU ; GURNANI, KOMAL ; ZAFER, AHMED ; EVERSON, ELLEN S. ; YOUNG, KEVIN G. ; RÜSSMANN, HOLGER ; KRISHNAN, LAKSHMI ; SAD, SUBASH . Modulation of Antigenic Location Converts Chronic into Acute Infection by Forcing CD8+ T Cell Recognition. Cell Reports , v. 2, p. 1710-1721, 2012.
OLIVEIRA, ANA-CAROLINA ; DE ALENCAR, BRUNA C. ; TZELEPIS, FANNY ; KLEZEWSKY, WEBERTON ; DA SILVA, RAQUEL N. ; NEVES, FABIENI S. ; CAVALCANTI, GISELE S. ; BOSCARDIN, SILVIA ; NUNES, MARISE P. ; SANTIAGO, MARCELO F. ; NÓBREGA, ALBERTO ; RODRIGUES, MAURÍCIO M. ; BELLIO, MARIA . Impaired Innate Immunity in Tlr4−/− Mice but Preserved CD8+ T Cell Responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-Deficient Mice. PLoS Pathogens (Online) , v. 6, p. e1000870, 2010.
HAOLLA, FA ; CLASER, C. ; Alencar, B. C. G. ; TZELEPIS, F. ; de VASCONCELOS JR, ; de Oliveira, G ; Silverio, JC ; MACHADO, A. V. ; BRUNA-ROMERO, O. ; Gazzinelli, R. T. ; dos SANTOS, RR. ; SOARES, M. B. ; RODRIGUES, M. M. . Strain-specific protective immunity following vaccination against experimental Trypanosoma cruzi infection.. Vaccine (Guildford) , v. 27, p. 5644-5653, 2009.
RODRIGUES, M. M. ; Alencar, B. C. G. ; CLASER, C. ; TZELEPIS, F. ; SILVEIRA, E. L. ; HAOLLA, FA ; DOMINGUEZ, M. R. ; de VASCONCELOS JR, . Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice.. Memórias do Instituto Oswaldo Cruz (Impresso) , v. 104, p. 281-287, 2009.
MONTEIRO, R. M. ; CAMARA, N. O. ; RODRIGUES, M. M. ; TZELEPIS, F. ; DAMIAO, M. J. ; CENEDEZE, M. A. ; TEIXEIRA, Vde P ; dos REIS, M. A. ; PACHECO-SILVA, A. . A role for regulatory T cells in renal acute kidney injury.. Transplant Immunology , v. 21, p. 50-55, 2009.
TZELEPIS, F. ; Alencar, B. C. G. ; Penido, M.L.O. ; CLASER, C. ; MACHADO, A. V. ; BRUNA-ROMERO, O. ; Gazzinelli, R. T. ; RODRIGUES, M. M. . Infection with Trypanosoma cruzi Restricts the Repertoire of Parasite-Specific CD8+ T Cells Leading to Immunodominance.. Journal of Immunology (Baltimore) , v. 180, p. 1737-1748, 2008.
RODRIGUES, M. M. ; Alencar, B. C. G. ; CLASER, C. ; TZELEPIS, F. . Immunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas disease.. Brazilian Journal of Medical and Biological Research (Impresso) , v. 42, p. 220-223, 2008.
TZELEPIS, F. ; Persechini, P. M. ; RODRIGUES, M. M. . Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load.. PLoS ONE , v. 2, p. e393-e403, 2007.
ROSA, D. S. ; Bastos, K.R. ; BARGIERI, D. Y. ; TZELEPIS, F. ; Russo, M ; Nomizo, A ; SOARES, I. S. ; RODRIGUES, M. M. . Role of Interferon-gamma during CpG oligodeoxynucleotide-adjuvanted immunization with recombinant proteins.. Vaccine (Guildford) , v. 00, p. 00-6, 2007.
TZELEPIS, F. ; Alencar, B. C. G. ; Penido, M.L.O. ; Gazzinelli, R. T. ; Persechini, P. M. ; RODRIGUES, M. M. . Distinct kinetics of effector CD8+ cytotoxic T cells after infection with Trypanosoma cruzi in naïve or vaccinated mice. Infection and Immunity , v. 74, p. 2477-2481, 2006.
ROSA, D. S. ; IWAI, L. K. ; TZELEPIS, F. ; BARGIERI, D. Y. ; MEDEIROS, M. A. ; SOARES, I. S. ; SIDNEY, J. ; KALIL, J. ; MELLO, L. E. ; CUNHA-NETO, E. ; RODRIGUES, M. M. . Immunogenicity of a recombinant protein containing the Plasmodium vivax vaccine candidate MSP1(19) and two human CD4(+) T-cell epitopes administered to non-human primates (Callithrix jacchus jacchus).. Microbes and Infection , v. 8, p. 2130-2137, 2006.
ROSA, D. S. ; TZELEPIS, F. ; CUNHA, M. G. ; SOARES, I. S. ; RODRIGUES, M. M. . The pan HLA-DR-binding epitope improves adjuvant-assisted immunization with a recombinant protein containing a malaria vaccine candidate. Immunology Letters , v. 92, p. 259-268, 2004.
TZELEPIS, F. ; RODRIGUES, M. M. . Size of infectious dose controls the tempo of Trypanosoma cruzi multiplication and the kinetics of specific CD8+ T cell expansion. In: Intenational Symposium "Molecular Immunology of Protozoan Infections", 2007, Buenos Aires. Intenational Symposium "Molecular Immunology of Protozoan Infections", 2007.
TZELEPIS, F. ; Alencar, B. C. G. ; Penido, M.L.O. ; CLASER, C. ; BOSCARDIN, S. B. ; MACHADO, A. V. ; BRUNA-ROMERO, O. ; Gazzinelli, R. T. ; RODRIGUES, M. M. . MHC heterozygosis reduces specific CD8+T cell immune response to Trypanosoma cruzi epitopes: evidence for T cell competition for antigen presenting cells during infection with a human pathogen.. In: 13th International Congress of Immunology, 2007, Rio de Janeiro. 13th International Congress of Immunology, 2007.
TZELEPIS, F. ; Alencar, B. C. G. ; Penido, M.L.O. ; CLASER, C. ; MACHADO, A. V. ; BRUNA-ROMERO, O. ; Gazzinelli, R. T. ; RODRIGUES, M. M. . Mechanisms of immunodominance during CD8+ T cells immune responses to Trypanosoma cruzi.. In: XXXIV Annual Meeting on basic research in Chagas'Disease and XXIII Annual meeting of the Brazilian Society of Protozoology, 2007, Caxambu. XXXIV Annual Meeting on basic research in Chagas'Disease and XXIII Annual meeting of the Brazilian Society of Protozoology, 2007.
TZELEPIS, F. ; Alencar, B. C. G. ; Penido, M.L.O. ; Gazzinelli, R. T. ; Persechini, P. M. ; RODRIGUES, M. M. . CD8+ cytotoxic T cells in Trypanosoma cruzi infected mice: Kinetics and possible mecanisms of action. In: 6th International Cell Death Society Symposium, 2006, Angra dos Reis. 6th International Cell Death Society Symposium, 2006.
TZELEPIS, F. ; RODRIGUES, M. M. . Size of infectious dose controls the tempo of Trypanosoma cruzi multiplication and the kinetics of specific CD8+ T cell expansion. In: XXXI Meeting of the Brazilian Society for Immunology, 2006, Buzios. XXXI Meeting of the Brazilian Society for Immunology, 2006.
TZELEPIS, F. ; RODRIGUES, M. M. . Size of infectious dose controls the tempo of Trypanosoma cruzi multiplication and the kinetics of specific CD8+ T cell expansion. In: VI São Paulo Research Conference, 2006, São Paulo. VI São Paulo Research Conference, 2006.
TZELEPIS, F. ; RODRIGUES, M. M. . Kinetics of the expansion of CD8+ T cells during experimental infection with a human parasite, Trypanosoma cruzi. In: XXX Meeting of the Brazilian Society of Immunology, 2005, São Pedro. XXX Meeting of the Brazilian Society of Immunology, 2005. p. 197-197.
ROSA, D. S. ; TZELEPIS, F. ; Bastos, K.R. ; Russo, M ; SOARES, I. S. ; RODRIGUES, M. M. . Interferon-g plays a critical role in CpG oligodeoxynucleotide-adjuvanted immunization with recombinant proteins. In: II São Paulo Research Conference Mechanisms of infection and vaccines, 2004, São Paulo. II São Paulo Research Conference Mechanisms of infection and vaccines, 2004.
ROSA, D. S. ; TZELEPIS, F. ; CUNHA, M. G. ; SOARES, I. S. ; RODRIGUES, M. M. . Role of endogenous interferon-gamma in CPG ODN- or others adjuvants-assisted immunizations using a recombinant malaria vaccine candidate. In: XXX Annual Meeting on Basic Research in Chagas Disease, 2003, Caxambu. XXX Annual Meeting on Basic Research in Chagas Disease, 2003. p. 65-65.
ARAUJO, A. F. S. ; TZELEPIS, F. ; BOSCARDIN, S. B. ; RODRIGUES, M. M. . Mapping CD4 T-cell epiotopes within the amastigote surface protein-2 of Trypanosoma cruzi. In: XXX Annual Meeting on Basic Research in Chagas Disease, 2003, Caxambu. XXX Annual Meeting on Basic Research in Chagas Disease, 2003. p. 135-135.
ROSA, D. S. ; TZELEPIS, F. ; CUNHA, M. G. ; SOARES, I. S. ; RODRIGUES, M. M. . Role of endogenous interferon-gamma in CpG ODN or other adjuvants-assisted immunizations using a recombinant malaria vaccine candidate. In: Participação no XXVIII Meeting of the Brazilian Society of Immunology, 2003, Manguaratiba. Participação no XXVIII Meeting of the Brazilian Society of Immunology, 2003.
TZELEPIS, F. ; ROSA, D. S. ; CUNHA, M. G. ; SOARES, I. S. ; RODRIGUES, M. M. . T cell specifity and function during the antibody immune response induced by recombinant proteins representing Plasmodium vivax candidate (MSP119). In: XXVII Meeting of the Brazilian society of immunology & V International symposium on allergy and clinical immunology, 2002, Salvador. XXVII Meeting of the Brazilian society of immunology & V International symposium on allergy and clinical immunology, 2002. p. 76-76.
ROSA, D. S. ; TZELEPIS, F. ; CUNHA, M. G. ; SOARES, I. S. ; RODRIGUES, M. M. . Potency and longevity of the immune response to a recombinant protein representing Plasmodium vivax malaria vaccine in different adjuvant formulations. In: XXVII Meeting of the Brazilian society of immunology & V International symposium on allergy and clinical immunology, 2002, Salvador. XXVII Meeting of the Brazilian society of immunology & V International symposium on allergy and clinical immunology, 2002. p. 75-75.
TZELEPIS, F. ; ROSA, D. S. ; CUNHA, M. G. ; SOARES, I. S. ; RODRIGUES, M. M. . T cell specifity and function during the antibody immune response induced by recombinant proteins representing Plasmodium vivax candidate (MSP119). In: 10º Simpósio Internacional de Iniciação Científica da USP, 2002, Ribeirão Preto. 10º Simpósio Internacional de Iniciação Científica da USP, 2002.
TZELEPIS, F. ; ROSA, D. S. ; SOARES, I. S. ; CUNHA, M. G. ; RODRIGUES, M. M. . immunogenicity of plasmodium vivax MSP1-19: T-cell epitope mapping in diffrente bacterial recombinant proteins. In: XVII annual meeting of the brazilian society of protozoology, 2001, Caxambu. XVII annual meeting of the brazilian society of protozoology, 2001. p. 135-135.

Prêmios

2012

Premio de melhor apresentacao oral, MUHC-RI Respiratory Axis Research Day.

2006

Premio de melhor poster, 6th International cell death symposium.

Histórico profissional

Endereço profissional

McGill University, Meakins-Christie Laboratories. , 3626 rue Saint-Urbain - room 430, H2X 2P2 - Montreal, - Canadá, Telefone: (1) 5143983864, Ramal: 00144, URL da Homepage:

Experiência profissional

2012 - Atual

McGill University

Vínculo: Bolsista, Enquadramento Funcional: Postdoctoral fellow, Regime: Dedicação exclusiva.

2009 - 2011

Universidade de Ottawa

Vínculo: temporario, Enquadramento Funcional: Tutor of Immunology CBL - Medicine(undergrad