Gerhard Paul Püschel

Pós-doutorado

Produções bibliográficas

• Wieneke, N. ; Neuschäfer-Rube, F. ; Bode, L.M. ; KUNA, M. ; Andres, J. ; Carnevali Jr., L.C. ; Hirsch-Ernst, K.I. ; PÜSCHEL, Gerhard Paul . Synergistic acceleration of thyroid hormone degradation by phenobarbital and the PPAR? agonist WY14643 in rat hepatocytes. Toxicology and Applied Pharmacology , p. 1-28, 2009.

• Henkel, Janin ; Neuschäfer-Rube, Frank ; Pathe-Neuschäfer-Rube, Andrea ; Püschel, Gerhard P. . Aggravation by prostaglandin E of interleukin-6-dependent insulin resistance in hepatocytes. Hepatology (Baltimore) , p. NA-NA, 2009.

• WIENEKE, N ; HIRSCHERNST, K ; KUNA, M ; KERSTEN, S ; PUSCHEL, G ; Püschel, G.P. . PPAR?-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: Potential role in starvation adaptation. FEBS Letters , v. 581, p. 5617-5626, 2007.

• PATHE-NEUSCHAFER-RUBE, A ; RUBE, F Neuschafer ; PÜSCHEL, Gerhard Paul . Role of the ERC-motif in the proximal part of the second intracellular loop and the C-terminal domain of the human prostaglandin F 2alpha receptor (FP receptor) in G-protein coupling control. Biochemical Journal (London) , v. 388, p. 317-324, 2005.

• NEUSCHAFER-RUBE, F. ; HERMOSILLA, R. ; KUNA, M. ; PATHE-NEUSCHAFER-RUBE, A ; SCHULEIN, R. ; PÜSCHEL, Gerhard Paul . A Ser/Thr cluster within the C-terminal domain of the rat prostaglandin receptor EP3alpha is essential for agonist-induced phosphorylation, desensitization and internalization.. British Journal of Pharmacology , v. 145, p. 1132-1142, 2005.

• PÜSCHEL, Gerhard Paul . Control of hepatocyte metabolism by sympathetic and parasympathetic hepatic nerves. Anat Rec a Discov Mol Cell Evol Biol, v. 280A, n.1, p. 854-867, 2004.

• RUBE, F Neuschafer ; HERMOSILLA, R. ; REHWALD, M. ; RONNSTRAND, L. ; SGCHULEIN, R. ; WERNSTEDT, C. ; PÜSCHEL, Gerhard Paul . Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site. Biochemical Journal (London) , v. 379, p. 573-585, 2004.

• BOER, U. ; FENNEKOHL, A. ; PÜSCHEL, Gerhard Paul . Sensitization by interleukin-6 of rat hepatocytes to tumor necrosis factor alpha-induced apoptosis. Journal of Hepatology , v. 38, p. 728-735, 2003.

• RUBE, F Neuschafer ; ENGEMAIER, E. ; KOCH, S. ; BOER, U. ; PÜSCHEL, Gerhard Paul . Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochemical Journal (London) , v. 371, p. 443-449, 2003.

• FENNEKOHL, A. ; SUGIMOTO, Y. ; SEGI, E. ; MARUYAMA, T. ; ICHIKAWA, A. ; PÜSCHEL, Gerhard Paul . Contribution of the two Gs-coupled PGE2-receptors EP2-receptor and EP4-receptor to the inhibition by PGE2 of the LPS-induced TNFalpha-formation in Kupffer cells from EP2-or EP4-receptor-deficient mice. Pivotal role for the EP4-receptor in wild type Kupffer cells. Journal of Hepatology , v. 36, p. 328-334, 2002.

• RUBE, F Neuschafer ; MOLLER, U. ; PÜSCHEL, Gerhard Paul . Structure of the 5'-flanking region of the rat prostaglandin F(2alpha) receptor gene and its transcriptional control functions in hepatocytes. Biochemical and Biophysical Research Communications , v. 278, p. 278-285, 2000.

• BOER, U. ; RUBE, F Neuschafer ; MOLLER, U. ; PÜSCHEL, Gerhard Paul . Requirement of N-glycosylation of the prostaglandin E2 receptor EP3beta for correct sorting to the plasma membrane but not for correct folding. Biochemical Journal (London) , v. 350, p. 839-847, 2000.

• FENNEKOHL, A. ; LUCAS, M. ; PÜSCHEL, Gerhard Paul . Induction by interleukin 6 of G(s)-coupled prostaglandin E(2) receptors in rat hepatocytes mediating a prostaglandin E(2)-dependent inhibition of the hepatocyte's acute phase response. Hepatology. Rapid Literature Review , v. 31, p. 1128-1134, 2000.

• SCHIEFERDECKER, H L ; PESTEL, S. ; PÜSCHEL, Gerhard Paul ; GOTZE, O ; JUNGERMANN, K . Increase by anaphylatoxin C5a of glucose output in perfused rat liver via prostanoids derived from nonparenchymal cells: direct action of prostaglandins and indirect action of thromboxane A(2) on hepatocytes. Hepatology. Rapid Literature Review , v. 30, p. 454-461, 1999.

• RUBE, F Neuschafer ; OPPERMANN, M ; MOLLER, U. ; BOER, U. ; PÜSCHEL, Gerhard Paul . Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid. Molecular Pharmacology , v. 56, p. 419-428, 1999.

• REHWALD, M. ; RUBE, F Neuschafer ; VRIES, C de ; PÜSCHEL, Gerhard Paul . Possible role for ligand binding of histidine 81 in the second transmembrane domain of the rat prostaglandin F2alpha receptor. FEBS Letters , v. 443, p. 357-362, 1999.

• FENNEKOHL, A. ; SCHIEFERDECKER, H L ; JUNGERMANN, K ; PÜSCHEL, Gerhard Paul . Differential expression of prostanoid receptors in hepatocytes, Kupffer cells, sinusoidal endothelial cells and stellate cells of rat liver. Journal of Hepatology , v. 30, p. 38-47, 1999.

• SCHIEFERDECKER, H L ; PESTEL, S. ; ROTHERMEL, e ; PÜSCHEL, Gerhard Paul ; GOTZE, O ; JUNGERMANN, K . Stimulation by anaphylatoxin C5a of glycogen phosphorylase in rat hepatocytes via prostanoid release from hepatic stellate cells but not sinusoidal endothelial cells. FEBS Letters , v. 434, p. 245-250, 1998.

• BOIE, Y. ; STOCCO, R. ; SAWYER, N. ; SLIPETZ, D. M. ; UNGRIN, M. D. ; RUBE, F Neuschafer ; PÜSCHEL, Gerhard Paul ; METTERS, K. M. ; ABRAMOVITZ, M. . Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. European Journal of Pharmacology , v. 340, p. 227-241, 1997.

• RUBE, F Neuschafer ; HANECKE, K ; PÜSCHEL, Gerhard Paul . The C-terminal domain of the human EP4 receptor confers agonist-induced receptor desensitization in a receptor hybrid with the rat EP3beta receptor. FEBS Letters , v. 415, p. 119-124, 1997.

• RUBE, F Neuschafer ; HANECKE, K ; BLASCHKE, V ; JUNGERMANN, K ; PÜSCHEL, Gerhard Paul . The C-terminal domain of the Gs-coupled EP4 receptor confers agonist-dependent coupling control to Gi but no coupling to Gs in a receptor hybrid with the Gi-coupled EP3 receptor. FEBS Letters , v. 401, p. 185-190, 1997.

• BLASCHKE, V ; JUNGERMANN, K ; PÜSCHEL, Gerhard Paul . Exclusive expression of the Gs-linked prostaglandin E2 receptor subtype 4 mRNA in mononuclear Jurkat and KM-3 cells and coexpression of subtype 4 and 2 mRNA in U-937 cells. FEBS Letters , v. 394, p. 39-43, 1996.

• PÜSCHEL, Gerhard Paul ; NOLTE, A ; SCHIEFERDECKER, H L ; ROTHERMEL, e ; GOTZE, O ; JUNGERMANN, K . Inhibition of anaphylatoxin C3a- and C5a- but not nerve stimulation- or Noradrenaline-dependent increase in glucose output and reduction of flow in Kupffer cell-depleted perfused rat livers. Hepatology. Rapid Literature Review , v. 24, p. 685-690, 1996.

• STUMPEL, F ; KUCERA, T ; BAZOTTE, R ; PÜSCHEL, Gerhard Paul . Loss of regulation by sympathetic hepatic nerves of liver metabolism and haemodynamics in chronically streptozotocin-diabetic rats. Diabetologia (Berlin) , v. 39, p. 161-165, 1996.

• HESPELING, U ; JUNGERMANN, K ; PÜSCHEL, Gerhard Paul . Feedback-inhibition of glucagon-stimulated glycogenolysis in hepatocyte/Kupffer cell cocultures by glucagon-elicited prostaglandin production in Kupffer cells. Hepatology. Rapid Literature Review , v. 22, p. 1577-1583, 1995.

• HESPELING, U ; PÜSCHEL, Gerhard Paul ; JUNGERMANN, K ; GOTZE, O ; ZWIRNER, J . Stimulation of glycogen phosphorylase in rat hepatocytes via prostanoid release from Kupffer cells by recombinant rat anaphylatoxin C5a but not by native human C5a in hepatocyte/Kupffer cell co-cultures. FEBS Letters , v. 372, p. 108-112, 1995.

• PÜSCHEL, Gerhard Paul ; CHRIST, B . Inhibition by PGE2 of glucagon-induced increase in phosphoenolpyruvate carboxykinase mRNA and acceleration of mRNA degradation in cultured rat hepatocytes. FEBS Letters , v. 351, p. 353-356, 1994.

• RUBE, F Neuschafer ; VRIES, C de ; HANECKE, K ; JUNGERMANN, K ; PÜSCHEL, Gerhard Paul . Molecular cloning and expression of a prostaglandin E2 receptor of the EP3 beta subtype from rat hepatocytes. FEBS Letters , v. 351, p. 119-122, 1994.

• WATANABE, Y ; PÜSCHEL, Gerhard Paul ; GARDEMANN, A ; JUNGERMANN, K . Presinusoidal and proximal intrasinusoidal confluence of hepatic artery and portal vein in rat liver: functional evidence by orthograde and retrograde bivascular perfusion. Hepatology. Rapid Literature Review , v. 19, p. 1198-1207, 1994.

• PÜSCHEL, Gerhard Paul ; JUNGERMANN, K . Integration of function in the hepatic acinus: intercellular communication in neural and humoral control of liver metabolism. Prog Liver Dis, v. 12, p. 19-46, 1994.

• PÜSCHEL, Gerhard Paul ; KIRCHNER, C ; SCHRODER, A ; JUNGERMANN, K . Glycogenolytic and antiglycogenolytic prostaglandin E2 actions in rat hepatocytes are mediated via different signalling pathways. European Journal of Biochemistry , v. 218, p. 1083-1089, 1993.

• PÜSCHEL, Gerhard Paul ; HESPELING, U ; OPPERMANN, M ; DIETER, P . Increase in prostanoid formation in rat liver macrophages (Kupffer cells) by human anaphylatoxin C3a. Hepatology. Rapid Literature Review , v. 18, p. 1516-1521, 1993.

• PÜSCHEL, Gerhard Paul ; MIURA, H ; RUBE, F Neuschafer ; JUNGERMANN, K . Inhibition by the protein kinase C activator 4 beta-phorbol 12-myristate 13-acetate of the prostaglandin F2 alpha-mediated and noradrenaline-mediated but not glucagon-mediated activation of glycogenolysis in rat liver. European Journal of Biochemistry , v. 217, p. 305-311, 1993.

• RUBE, F Neuschafer ; PÜSCHEL, Gerhard Paul ; JUNGERMANN, K . Characterization of prostaglandin-F2 alpha-binding sites on rat hepatocyte plasma membranes. European Journal of Biochemistry , v. 211, p. 163-169, 1993.

• GARDEMANN, A ; PÜSCHEL, Gerhard Paul ; JUNGERMANN, K . Characterization of prostaglandin-F2 alpha-binding sites on rat hepatocyte plasma membranes. European Journal of Biochemistry , v. 207, p. 399-411, 1992.

• ULKEN, V ; PÜSCHEL, Gerhard Paul ; JUNGERMANN, K . Increase in glucose and lactate output and perfusion resistance by stimulation of hepatic nerves in isolated perfused rat liver: role of alpha 1-, alpha 2-, beta 1- and beta 2-receptors. Biol. Chem. Hoppe-Seyler , v. 372, p. 401-409, 1991.

• PÜSCHEL, Gerhard Paul ; OPPERMANN, M ; RUBE, F Neuschafer ; GOTZE, O ; JUNGERMANN, K . Differential effects of human anaphylatoxin C3a on glucose output and flow in rat liver during orthograde and retrograde perfusion: the periportal scavenger cell hypothesis. Biochemical and Biophysical Research Communications , v. 176, p. 1218-1226, 1991.

• MUSCHOL, W ; PÜSCHEL, Gerhard Paul ; HULSMANN, M ; JUNGERMANN, K . Eicosanoid-mediated increase in glucose and lactate output as well as decrease and redistribution of flow by complement-activated rat serum in perfused rat liver. European Journal of Biochemistry , v. 196, p. 525-530, 1991.

• PÜSCHEL, Gerhard Paul ; OPPERMANN, M ; MUSCHOL, W ; GOTZE, O ; JUNGERMANN, K . Increase of glucose and lactate output and decrease of flow by human anaphylatoxin C3a but not C5a in perfused rat liver. FEBS Letters , v. 243, p. 83-87, 1989.

• PÜSCHEL, Gerhard Paul ; JUNGERMANN, K . Activation of inositol phosphate formation by circulating noradrenaline but not by sympathetic nerve stimulation with a similar increase of glucose release in perfused rat liver. European Journal of Biochemistry , v. 175, p. 187-191, 1988.

• PÜSCHEL, Gerhard Paul ; NATH, A ; JUNGERMANN, K . Increase of urate formation by stimulation of sympathetic hepatic nerves, circulating noradrenaline and glucagon in the perfused rat liver. FEBS Letters , v. 219, p. 145-150, 1987.