Nicholas Farrell

Possui graduação em Bacharelado em Ciencias pela University College Dublin(1969), doutorado em Quimica pela University of Sussex(1973), pós-doutorado pela Simon Fraser University(1975) e pós-doutorado pela University of British Columbia(1977). Atualmente é Professor da Virginia Commonwealth University e Chefe do Departamento de Quimica da Virginia Commonwealth University. Tem experiência na área de Química.

Informações coletadas do Lattes em 12/12/2014

Acadêmico

Formação acadêmica

Doutorado em Quimica

1969 - 1973

University of Sussex
Título: Uses of Reactive Alkylating Agents in Transition-Metal Chemistry
Orientador: A. Pidcock e C. Eaborn

Graduação em Bacharelado em Ciencias

1964 - 1969

University College Dublin

Pós-doutorado

1975 - 1977

Pós-Doutorado. , University of British Columbia.

1973 - 1975

Pós-Doutorado. , Simon Fraser University, Canadá.

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Espanhol

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Português

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Francês

Compreende Razoavelmente, Fala Razoavelmente, Lê Bem, Escreve Razoavelmente.

Áreas de atuação

Grande área: Ciências Exatas e da Terra / Área: Química.

Participação em eventos

Platinum Anticancer Agents. Structures and Targeted Biomolecules. International Chemical Congress of Pacific Basin Societies (Pacifichem). 2005. (Congresso).

Platinum Anticancer Agents. Structures and Targeted Biomolecules. American Chemical Society. 2005. (Congresso).

Polynuclear Platinum Complexes. Chemistry and Biology. Gordon Research Conference on Metals in Medicine. 2004. (Congresso).

Platinum Anticancer Agents. Structures and Targeted Biomolecules. COST D20 Workshop Metal Complexes in the treatment of Cancer and Viral diseases. 2003. (Congresso).

Platinum Anticancer Agents. Structures and Targeted Biomolecules. American Chemical Society Symposium on Medicinal Inorganic Chemistry, ACS Fall meeting. 2003. (Congresso).

Platinum Anticancer Agents. Structures and Targeted Biomolecules. Royal Australian Chemistry Institute, Inorganic Chemistry Symposium. 2003. (Congresso).

Polynuclear Platinum Drugs. Platinum-DNA Interactions. 10th International Conference on Bioinorganic Chemistry (ICBIC 10). 2001. (Congresso).

Platinum-DNA Interactions. Implications for New Drugs . In New Trends in Biofunctional Metal Complexes. International Chemical Congress of Pacific Basin Societies. 2000. (Congresso).

Platinum-DNA Interactions. Implications for New Drugs . In Recent Advances on the Interaction of Metal Complexes with Nucleic Acids and Their Components".. American Chemical Society Meeting. 2000. (Congresso).

Platinum-DNA Interactions. Implications for New Drugs. International Conference on DNA Conformation, Modification and Recognition in Biomedicine. 2000. (Congresso).

Principles of Medicinal Chemistry for Inorganics. Metals in Medicine workshop, National Institutes of Health. 2000. (Congresso).

New Platinum Compounds. Meet the Expert Sunrise Session, 91st AACR. 2000. (Congresso).

Orientou

C; Tran; New Platinum Antitumor drug (1,0,1/t,t,t) Interaction with DNA: DNA Conformational changes and Long-Range Pt-DNA Adduct; ; 1998; Dissertação (Mestrado em quimica) - Virginia Commonwealth University,; Orientador: Nicholas Farrell;

A; Eckel; In Vivo and In Vitro Characterization of Novel Dinuclear and Thiazole-Containing Platinum Compounds; ; 1997; Dissertação (Mestrado em quimica) - Virginia Commonwealth University,; Orientador: Nicholas Farrell;

M; de Gomes Carneiro; Synthesis and Characterisation of Complexes of Palladium and Platinum with Nitroimidazoles and Nitrothiazoles; ; 1984; Dissertação (Mestrado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

G; Luna; Aspects of the Chemistry of Group VIII Metal Complexes with Dimethylsulfoxide Relevant to the Biological Activity of Metal Complexes; ; 1984; Dissertação (Mestrado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

H; Moreira; Synthesis, Characterization and Properties of Some Complexes of Ruthenium(II) with Amines and Nitroimidazoles; ; 1984; Dissertação (Mestrado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

B; Barczewski; Interaction of the Complex Oxobis(acetylacetonato)vanadium(IV) with Purine and Pyrimidine Bases; ; 1983; Dissertação (Mestrado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

M; Souza; The Use of 3-imino-2-ketoisoindoline as Intermediate in the Synthesis and Characterisation of Ruthenium-phthalocyanine; ; 1981; Dissertação (Mestrado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

A; Neves; Synthesis and Characterisation of Model Complexes of Nitrogenase; ; 1981; Dissertação (Mestrado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

G; de Almeida; Synthesis and Characterisation of Some Complexes of Ruthenium with Acetylacetone; ; 1981; Dissertação (Mestrado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

G; de Oliveira; Synthesis and Characterisation of Complexes of Ruthenium with Purines, Pyrimidines and Nucleosides; ; 1980; Dissertação (Mestrado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

Amanda L

Harris; The Interactions Between Multinuclear Platinum Compounds and DNA: Investigation of Non-covalent Compounds by Chemical and Biological Methods; 2005; Tese (Doutorado em Quimica) - Virginia Commonwealth University, Virginia Commonwealth University; Orientador: Nicholas Farrell;

C; Oehlsen; Model Studies on the Metabolism of Anticancer Active Polynuclear Platinum Complexes; 2003; Tese (Doutorado em Quimica) - Virginia Commonwealth University,; Orientador: Nicholas Farrell;

D; McGregor; Dinuclear platinum complexes with Polyamine Derivative Linker Groups; Focus on Binding and conformational changes of DNA; ; 2001; Tese (Doutorado em quimica) - Virginia Commonwealth University,; Orientador: Nicholas Farrell;

W; Cox; Interactions Between Multinuclear Platinum Complexes and DNA with a Focus on Ligands, Linker groups, and Kinetics: A Molecular Modelling and [1H, 15N] NMR Study; ; 2000; Tese (Doutorado em quimica) - Virginia Commonwealth University,; Orientador: Nicholas Farrell;

Wu; DNA Interactions of Bis(platinum) Complexes; ; 1995; Tese (Doutorado em quimica) - University of Vermont,; Orientador: Nicholas Farrell;

-J; van Buesichem-Doedee; Activation of the Trans Geometry in Platinum Anticancer Agents; ; 1994; Tese (Doutorado em quimica) - University of Vermont,; Orientador: Nicholas Farrell;

P; Soares-Fontes; Synthesis and Invesitigation of the Mechanism of Antitumor Activity of New Platinum Complexes; ; 1993; Tese (Doutorado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

G; de Almeida; Synthesis and Characterization of Bis(platinum) Complexes; ; 1990; Tese (Doutorado em Química) - Universidade Federal de Minas Gerais,; Orientador: Nicholas Farrell;

Produções bibliográficas

Chvalova K ; Kasparkova J ; FARRELL, N. . Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes. FEBS Letters , v. 273, p. 3467-3478, 2006.
Bullus G ; Knott KM ; Ma ESF ; FARRELL, N. . trans-platinum planar amine compounds with [N2O2] ligand donor sets: Effects of carboxylate leaving groups and steric hindrance on chemical and biological properties. Inorganic Chemistry , v. 45, p. 5733-5735, 2006.
Anzellotti A ; Stefan S ; Gibson D ; FARRELL, N. . Donor atom preferences in substitution reactions of trans-platinum mononucleobase compounds: Implications for DNA-protein selectivity. Inorganica Chimica Acta , v. 359, p. 3014-3023, 2006.
Anzellotti AI ; Liu, Q ; Bloemink MJ ; FARRELL, N. . Targeting retroviral Zn finger-DNA interactions: A small-molecule approach using the electrophilic nature of trans-platinum-nucleobase compounds. Chemistry & Biology (London) , v. 13, p. 539, 2006.
Liu, Q ; Y, Q. ; Van Antwerpen R ; FARRELL, N. . Mechanism of the membrane interaction of polynuclear platinum anticancer agents. Implications for cellular uptake. Biochemistry (Easton) , v. 45, p. 4248, 2006.
Anzellotti AI ; Sabat M ; FARRELL, N. . Covalent and noncovalent interactions for [metal(dien)nucleobase](2+) complexes with L-tryptophan derivatives: Formation of palladium-tryptophan species by nucleobase substitution under biologically relevant conditions. Inorganic Chemistry , v. 45, p. 1638, 2006.
Harris AL ; Ryan JJ ; FARRELL, N. . Biological consequences of trinuclear platinum complexes: comparison of [{trans-PtCl(NH3)(2)}(2)mu-(trans-Pt(NH3)(2)(H2N(CH2)(6)-NH2)(2))](4+) (BBR 3464) with its noncovalent congeners. Molecular Pharmacology , v. 69, p. 666, 2006.
Chvalova K ; Kasparkova J ; FARRELL, N. ; Brabec, V. . Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes. FEBS Letters , v. 273, p. 3467, 2006.
QUIROGA, G. A. ; PEREZ, J. M. ; NAVARRO-RANNINGER, C. ; FARRELL, N. . Novel Transplatinum(II) complexes with [N2O2] donor sets. Cellular Pharmacology and Apoptosis Induction in Pam 212-ras Cells.. Journal of Medicinal Chemistry , v. 49, p. 224, 2006.
BILLECKE, C. ; FINNISS, S. ; TAHASH, L. ; MILLER, C. ; FARRELL, N. ; BOGLER, O. . Sensitivity of glioma cells in vitro and in vivo to platinum anticancer drugs. Polynuclear agents are more potent than cisplatin and induce cell cycle arrest.. Journal of Neuro-Oncology , v. 8, p. 215, 2006.
Liu, Q ; Golden M ; DARENSBORG, ; FARRELL, N. . Thiolate-Bridged heterodinuclear Platinum-Zinc chelates as models for ternary Platinum-DNA-Protein Complexes and zinc ejection from zinc fingers. Evidence from studies using ESI-Mass Spectrometry. Chemical Communications (London) , v. 23, p. 4523, 2005.
Harris AL ; YANG, X. ; HEGMANS, A. ; POVIRK, L. ; Ryan JJ ; Kelland L R ; FARRELL, N. . Synthesis and Characterization of the DNA Binding and Cytotoxicity of a Novel Trinuclear Highly Charged Compound.. Inorganic Chemistry , v. 44, p. 9598, 2005.
Zhang, J. ; Thomas, D.S. ; Davies, M.S. ; Berners-Price S J ; FARRELL, N. . Effects of geometric isomerism in dinuclear platinum antitumor complexes on aquation reactions in the presence of perchlorate, acetate and phosphate. JBIC. Journal of Biological Inorganic Chemistry , v. 10, p. 652, 2005.
Marini, V. ; Christofis, P. ; Novakova, O. ; Kasparkova J ; FARRELL, N. ; Brabec, V. . Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)].. Nucleic Acids Research , v. 33, p. 5819, 2005.
Oehlsen, M.E. ; Hegmans A ; Y, Q. ; FARRELL, N. . Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine.. JBIC. Journal of Biological Inorganic Chemistry , v. 10, p. 433, 2005.
MA, E. S. ; BATES, W. D. ; EDMUNDS, A. ; Kelland L R ; FARRELL, N. . Enhancement of Aqueous Solubility and Stability Employing a Trans Acetate Axis in Transplanar Amine Platinum Compounds while Maintaining the Biological Profile.. Journal of Medicinal Chemistry , v. 48, p. 5651, 2005.
Ourliac-Garnier. I. ; Elizondo-Riojas, M. ; Redon, S. ; FARRELL, N. ; Bombard, S. . Cross-linking of the quadruplex structures of the AG3(T2AG3)3 human telomere sequences in Na+ and K+ solutions by dinuclear platinum complexes.. Biochemistry (Easton) , v. 44, p. 10620, 2005.
Quintal, S.M.O. ; Y, Q. ; Gomez-Quiroga, A ; Moniodis, J ; Nogueira, H.I.S. ; FARRELL, N. . Pyridine-carboxylate complexes of platinum. Effect of N,O-chelate formation on model bifunctional DNA-DNA and DNA-protein interactions.. Inorganic Chemistry , v. 44, p. 5247, 2005.
Oehlsen, M.E. ; HEGMANS, A. ; Y, Q. ; FARRELL, N. . A Surprisingly Stable Macrochelate Formed from the Reaction of cis-dinuclear Platinum Antitumor Compounds with Reduced Glutathione. Identification by the Use of (1H-15N and 195Pt) NMR Spectroscopy and Electrospray Ionization Mass Spectrometry.. Inorganic Chemistry , v. 44, p. 3004, 2005.
Harris AL ; Y, Q. ; FARRELL, N. . Unique cooperative binding interaction observed between a minor groove binding Pt anti-tumor agent and Hoeschst Dye 33258.. Inorganic Chemistry , v. 44, p. 1196, 2005.
Anzellotti AI ; Ma ESF ; FARRELL, N. . .: Platination of nucleobases to enhance non-covalent recognition in protein-DNA/RNA complexes.. Inorganic Chemistry , v. 44, p. 483, 2005.
FOJO, T. ; FARRELL, N. ; ORTUZAR, W. ; Tanimura, H. ; Weinstein, J. ; Myers, T.G. . Identification of non-cross-resistant platinum compounds with novel cytotoxicity profiles using the NCI anticancer drug screen and clustered image map visualizations.. Crit. Revs. Oncol./Hematol. , v. 53, p. 25, 2005.
Kasparkova J ; Fojta, M. ; FARRELL, N. ; Brabec, V. . Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and. Nucleic Acids Research , v. 32, p. 5546, 2004.
Y, Q. ; Harris AL ; HEGMANS, A. ; PETZ, A. ; PENAZOVA, H. ; FARRELL, N. . Synthesis and DNA Conformational Changes of Non-covalent Polynuclear Platinum Complexes. Journal of Inorganic Biochemistry , v. 98, p. 1591, 2004.
Y, Q. ; Scarsdale, N.J ; Tran M C ; FARRELL, N. . Comparison of Structural Effects in 1,4 DNA-DNA Interstrand Cross-links Formed by Dinuclear and Trinuclear Platinum Complexes.. Journal of Inorganic Biochemistry , v. 98, p. 1585, 2004.
Kasparkova J ; Vrana, O. ; FARRELL, N. ; Brabec, V. . Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding.. Journal of Inorganic Biochemistry , v. 98, p. 1560, 2004.
FARRELL, N. ; POVIRK, L. ; DANGE, Y. ; GUPTA, M. S. ; KOHLHAGEN, G. ; POMMIER, Y. ; GEWIRTZ, D. . Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF 7 breast carcinoma cells.. Biochemical Pharmacology , v. 68, p. 857, 2004.
KLOSTER, M. ; KOSTRHUNOVA, H. ; ZALUDOVA, R. ; MALINA, J. ; Kasparkova J ; Brabec, V. ; FARRELL, N. . Trifunctional Dinuclear Platinum Complexes as DNA-Protein Crosslinking Agents.. Biochemistry (Easton) , v. 43, p. 7776, 2004.
HEGMANS, A. ; Berners-Price S J ; Davies M S ; THOMAS, D. ; HUMPHREYS, A. ; FARRELL, N. . Long Range 1,4 and 1,6-Interstrand Cross-Links Formed by a Trinuclear Platinum complex. Minor Groove Pre-association Affects Kinetics and Mechanism of Cross-Link Formation as well as Adduct Structure.. Journal of the American Chemical Society , v. 126, p. 2166, 2004.
Oehlsen, M.E. ; Y, Q. ; FARRELL, N. . Reaction of Polynuclear Platinum Antitumor Compounds with Reduced Glutathione Studied by Multinuclear (1H,{1H-15N} HSQC and 195Pt) NMR Spectroscopy.. Inorganic Chemistry , v. 42, p. 5498, 2003.
Davies M S ; Berners-Price S J ; Cox J W ; FARRELL, N. . The nature of the DNA template (single-stranded versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug.. Journal of the Chemical Society, Chemical Communications , v. 01, p. 122, 2003.
Kasparkova J ; Novakova, O. ; FARRELL, N. ; Brabec, V. . DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts.. Biochemistry (Easton) , v. 42, p. 792, 2003.
Najajreh, Y. ; Peleg-Shulman, T. ; Moshel, O. ; FARRELL, N. ; Gibson D . Ligand effects on the binding of cis- and trans-[PtCl2LL ] to proteins.. JBIC. Journal of Biological Inorganic Chemistry , v. 8, p. 19, 2003.
Berners-Price S J ; Davies M S ; Cox J W ; Thomas, D.S. ; FARRELL, N. . Competitive Reactions of Interstrand and Intrastand DNA-Pt Adducts. A Dinuclear Platinum Complex Preferentially Forms a 1,4 Interstrand Cross-Link Rather than a 1,2 Intrastrand Crosslink on Binding to a GG 14-mer Duplex. European Journal of Inorganic Chemistry , v. 9, p. 713, 2003.
Y, Q. ; Scarsdale, N.J. ; Tran M C ; FARRELL, N. . Cooperative effects in Long-range 1,4 DNA-DNA Interstrand Cross-links formed by Polynuclear Platinum Complexes. An Unexpected syn-Orientation of Adenine Bases Outside the Binding Sites.. JBIC. Journal of Biological Inorganic Chemistry , v. 8, p. 19, 2003.
Y, Q. ; Scarsdale, N.J. ; Tran M C ; FARRELL, N. . Cooperative effects in Long-range 1,4 DNA-DNA Interstrand Cross-links formed by Polynuclear Platinum Complexes. An Unexpected syn-Orientation of Adenine Bases Outside the Binding Sites.. JBIC. Journal of Biological Inorganic Chemistry , v. 8, p. 19, 2003.
Kasparkova J ; Zehnulova J ; FARRELL, N. ; Brabec, V. . DNA Interstrand Crosslinks of Novel Antitumor Trinuclear Platinum Complex BBR3464. Conformation, Recognition by HMG-Domain Proteins and Nucleotide Excision Repair.. Journal of Biological Chemistry (Online) , v. 277, p. 48076, 2002.
McGregor T D ; Bousfield, W. ; Y, Q. ; FARRELL, N. . Dichroism Study of the Irreversibility of Conformational Changes Induced by Polyamine-linked Dinuclear Platinum Compounds.. Journal of Inorganic Biochemistry , v. 91, p. 212, 2002.
Davies M S ; Thomas, D.S. ; HEGMANS, A. ; Berners-Price S J ; FARRELL, N. . Kinetic and Equilibria Studies of the Aquation of the Trinuclear Platinum Phase II Anticancer Agent [{trans-PtCl(NH3)2}2{-trans-Pt(NH3)2(NH2(CH2)6NH2)2}]4+ (BBR3464).. Inorganic Chemistry , v. 41, p. 1101, 2002.
McGregor T D ; Kasparkova J ; Neplechova K ; PENAZOVA, H. ; Vrana, O. ; Brabec, V. ; FARRELL, N. . A Comparison of DNA Binding Profiles of Dinuclear Platinum Compounds with Polyamine Linkers and the Trinuclear Platinum Phase II Clinical Agent BBR3464.. JBIC. Journal of Biological Inorganic Chemistry , v. 7, p. 397, 2002.
McGregor T D ; Kasparkova J ; Neplechova K ; PENAZOVA, H. ; Vrana, O. ; Brabec, V. ; FARRELL, N. . A Comparison of DNA Binding Profiles of Dinuclear Platinum Compounds with Polyamine Linkers and the Trinuclear Platinum Phase II Clinical Agent BBR3464.. JBIC. Journal of Biological Inorganic Chemistry , v. 7, p. 397, 2002.
Wang Y ; FARRELL, N. ; Burgess J D . Direct evidence for preassociation preceding covalent binding in the reaction of cis-[Pt(NH3)2(H2O)2]2+ with surface immobilized oligonucleotides.. Journal of the American Chemical Society , v. 123, p. 5573, 2001.
Hegmans A ; Y, Q. ; Kelland L R ; Roberts, J. D. ; FARRELL, N. . Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates.. Inorganic Chemistry , v. 40, p. 6108, 2001.
Y, Q. ; Fitzgerald J A ; Rauter, H ; FARRELL, N. . Approaches to selective DNA binding in polyfunctional dinuclear platinum chemistry. The synthesis of a trifunctional compound and its interaction with the mononucleotide 5'-guanosine monophosphate.. Inorganic Chemistry , v. 40, p. 6324, 2001.
Cox J W ; Berners-Price S J ; Davies M S ; Y, Q. ; FARRELL, N. . Kinetic analysis of the stepwise formation of a long-range DNA interstrand cross-link by a dinuclear platinum antitumor complex: evidence for aquated intermediates and formation of both kinetically and thermodynamically controlled conformers.. Journal of the American Chemical Society , v. 123, p. 1316, 2001.
Zehnulova J ; Kasparkova J ; FARRELL, N. ; Brabec, V. . Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair of DNA intrastrand cross-links of novel antitumor trinuclear platinum complex BBR3464.. The Journal of Biological Chemistry , v. 276, p. 22191, 2001.
Hofr C ; FARRELL, N. ; Brabec, V. . Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex.. Nucleic Acids Research , v. 29, p. 2034, 2001.
Fontes A P ; Oskarsson A ; Lovqvist K ; FARRELL, N. . Synthesis, characterization, and reactivity of trans-[PtCl(R'R''SO)(A)2]NO3 (R'R''SO = Me2SO, MeBzSO, MePhSO; A= NH3, py, pic). Crystal structure of trans-[PtCl(Me2SO)(py)2]+.. Inorganic Chemistry , v. 40, p. 1745, 2001.
Sartori, David A. ; Miller, Bernhard ; Bierbach, Ulrich ; FARRELL, N. . Modulation of the chemical and biological properties of trans platinum complexes: monofunctional platinum complexes containing one nucleobase as potential antiviral chemotypes.. Inorganic Chemistry , v. 5, p. 575, 2000.
Davies M S ; Cox J W ; Berners-Price S J ; Barklage W ; Y, Q. ; FARRELL, N. . Equilibrium and kinetic studies of the aquation of the dinuclear platinum complex [[trans-PtCl(NH3)2]2(mu-NH2(CH2)6NH2)]2+: pKa determinations of aqua ligands via [1H,15N] NMR spectroscopy.. Inorganic Chemistry , v. 39, p. 1710, 2000.
Bierbach, Ulrich ; Sabat M ; FARRELL, N. . Inversion of the cis geometry requirement for cytotoxicity in structurally novel platinum(II) complexes containing the bidentate N,O-donor pyridin-2-yl-acetate.. Inorganic Chemistry , v. 39, p. 1882, 2000.
Manzotti, C ; Pratesi, G ; Menta, E ; Di Domenico, R. ; Cavalletti E ; Fiebig H H ; Kelland L R ; FARRELL, N. ; Polizzi, D. ; Supino, R. ; Pezzoni, G ; Zunino, F . BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin. journal of the American Association for Cancer Research , v. 6, p. 2626, 2000.
Brabec, V. ; Neplechova K ; Kasparkova J ; FARRELL, N. . Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups.. JBIC. Journal of Biological Inorganic Chemistry , v. 5, p. 364, 2000.
Lemma K ; Berglund J ; FARRELL, N. ; Elding L I . Kinetics and mechanism for reduction of anticancer-active tetrachloroam(m)ine platinum(IV) compounds by glutathione.. JBIC. Journal of Biological Inorganic Chemistry , v. 5, p. 300, 2000.
Y, Q. ; Rauter, H ; Soares Fontes A P ; Bandarage R ; Kelland L R ; FARRELL, N. . Synthesis, characterization, and cytotoxicity of trifunctional dinuclear platinum complexes: comparison of effects of geometry and polyfunctionality on biological activity.. Journal of Medicinal Chemistry , v. 43, p. 3189, 2000.
Kasparkova J ; FARRELL, N. ; Brabec, V. . Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes.. The Journal of Biological Chemistry , v. 275, p. 15789, 2000.
Skov, K. A. ; Adomat, H. ; FARRELL, N. ; MacPhail, H.S. ; Zhou, H . A survey of radiosensitizing properties of bisplatinum complexes in hypoxic mammalian cells.. Recent Res. Devel. Inorg. Chem. , v. 2, p. 57, 2000.
Lemma, K. ; BERGLUND, J. ; FARRELL, N. ; ELDING, L. I. . Kinetics and Mechanism for Reduction of Anticancer Active Tetrachloroam(m)ine Platinum(IV) Compounds by Glutathione.. JBIC. Journal of Biological Inorganic Chemistry , v. 5, p. 300, 2000.
Bierbach, Ulrich ; Sabat M ; FARRELL, N. . Monofunctional Transplatinum Complexes Containing One Nucleobase as Potential Antiviral Chemotypes.. Inorganic Chemistry , v. 39, p. 1882, 2000.
Pratesi, G ; Perego, P. ; Polizzi, D. ; Righetti, S. C. ; Supino, R. ; Caserini, C. ; Manzotti, C ; Giuliani, F. C. ; Pezzoni, G ; Tognella, S ; Spinelli, S ; FARRELL, N. ; Zunino, F . A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: hypersensitivity of p53-mutant human tumour xenografts.. British Journal of Cancer , v. 80, p. 1912, 1999.
Perego, P. ; Caserini, C. ; Supino, R. ; Colangelo D ; Leone R ; Spinelli, S ; FARRELL, N. ; Zunino, F . The cellular basis of the efficacy of the trinuclear platinum complex BBR 3464 against cisplatin-resistant cells.. Journal of Inorganic Biochemistry , v. 77, p. 59, 1999.
Roberts J D ; Peroutka J ; FARRELL, N. . Cellular pharmacology of polynuclear platinum anti-cancer agents.. Journal of Inorganic Biochemistry , v. 77, p. 51, 1999.
Roberts J D ; Peroutka J ; Beggiolin G ; Manzotti, C ; Piazzoni L ; FARRELL, N. . Comparison of cytotoxicity and cellular accumulation of polynuclear platinum complexes in L1210 murine leukemia cell lines.. Journal of Inorganic Biochemistry , v. 77, p. 47, 1999.
McGregor T D ; Balcarova Z ; Y, Q. ; Tran M C ; Zaludova R ; Brabec, V. ; FARRELL, N. . Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes.. Journal of Inorganic Biochemistry , v. 77, p. 43, 1999.
Kloster M B ; Hannis J C ; Muddiman D C ; FARRELL, N. . Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug.. Biochemistry (Easton) , v. 38, p. 14731, 1999.
Kasparkova J ; Novakova, O. ; Vrana, O. ; FARRELL, N. . Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross-linking. Biochemistry.. Biochemistry (Easton) , v. 38, p. 10997, 1999.
Pratesi, G ; Righetti, S. C. ; Supino, R. ; Polizzi, D. ; Manzotti, C ; Giuliania, F.C. ; Pezzoni, G. ; Tognella, S. ; Spinelli, S ; Perego, P., ; FARRELL, N. ; Zunino, F . High Antitumor Activity of a Novel Multinuclear Platinum Complex against Cisplatin-resistant p53 Mutant Human Tumors.. British Journal of Cancer , v. 80, p. 1912, 1999.
Bierbach, Ulrich ; Y, Q. ; HAMBLEY, T. W. ; Peroutka J ; NGUYEN, H. ; DOEDEE, M. ; FARRELL, N. . Effect of L and cis/trans isomerism on Sequence Specificity and Unwinding Properties Observed in Globally Platinated DNA.. Inorganic Chemistry , v. 38, p. 3535, 1999.
Brabec, V. ; Kasparkova J ; Vrana, O. ; Novakova, O. ; Cox J W ; Y, Q. ; FARRELL, N. . A Novel Trinuclear Platinum Complex Overcomes Cisplatin resistance in an Osteosarcoma Cell System.. Biochemistry (Easton) , v. 38, p. 6781, 1999.
Perego, P., ; Caserini, C. ; GATTI, L. ; CARENINI, N. ; ROMANELLI, S. ; Supino, R. ; Colangelo D ; VIANO, I. ; Spinelli, S ; PEZZONI, G. ; Manzotti, C ; FARRELL, N. ; Zunino, F . Implications for the Mechanism of Action of Nonclassical Trans-Platinum Antitumor Complexes.. Molecular Pharmacology , v. 55, p. 528, 1999.
FARRELL, N. ; et al . Applications of inorganic chemistry in biology: an interdisciplinary graduate course.. Journal of Chemical Education , v. 75, p. 739-740, 1998.
Skov, K. A. ; Adomat, H. ; Matthews J B ; FARRELL, N. ; JAMES, B. R. . Assessment of toxicity of bis-platinum complexes in hypoxic and aerobic cells.. Anti-cancer drug design , v. 13, p. 207-211, 1998.
Bierbach, Ulrich ; FARRELL, N. . DNA interactions of antitumor trans-[PtCl2(NH3)quinoline].. JBIC. Journal of Biological Inorganic Chemistry , v. 3, p. 570, 1998.
KAKOVSKA, A. ; Novakova, O. ; BALCAROVA, Z. ; Bierbach, Ulrich ; FARRELL, N. ; Brabec, V. . DNA interactions of antitumor trans-[PtCl2(NH3)quinoline].. European Journal of Biochemistry , v. 254, p. 547, 1998.
SHAAF, T. G. ; Y, Q. ; FARRELL, N. ; WYSOCKI, V. H. . Investigation of Trans Influence in the Fragmentation of Dinuclear Platinum Complexes by Electrospray Ionization Surface-Induced Dissociation Tandem Mass Spectrometry.. Inorganic Chemistry , v. 37, p. 708, 1998.
Bierbach, Ulrich ; HAMBLEY, T. W. ; FARRELL, N. . Synthesis, Structure and Spectroscopic Properties of Cationic Complexes of Type [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L= Monofunctional Thiourea and L-L = Bifunctional Thiourea).. Inorganic Chemistry , v. 37, p. 708, 1998.
Bierbach, Ulrich ; ROBERTS, J. D. ; FARRELL, N. . Reactivity and Nucleotide Binding Properties of Cationic Complexes of Type [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L = Monofunctional Thiourea and L-L = Bifunctional Thiourea).. Inorganic Chemistry , v. 37, p. 717, 1998.
Kukushkin, V. Yu ; OSKARSSON, A. ; ELDING, L. I. ; FARRELL, N. . Simple Synthesis of Isomerically Pure cis-Dichlorodiammineplatinum(II), Cisplatin.. Inorganic Synthesis , v. 32, p. 141, 1998.
FARRELL, N. ; Menta, E ; Di Domenico, R. ; Da Re, G. ; Pezzoni, G ; Giuliani, F. C. ; Spinelli, S . Chemical and biological properties of a novel bifunctional triplatinum phase I clinical agent. Journal of Inorganic Biochemistry , v. 67, p. 173, 1997.
Y, Q. ; Bloemink MJ ; Rauter, H ; Smeds, K.A ; FARRELL, N. . Factors affecting formation and structure of DNA intrastrand cross-links by dinuclear platinum complexes.. Environment (St. Louis) , v. 26, p. 435, 1997.
Kharatishvili, M ; Mathieson, M ; FARRELL, N. . Effects of quinoline as ligand in binding of mononuclear and dinuclear platinum complexes to DNA.. Inorganica Chimica Acta , v. 255, p. 1, 1997.
Zaludova R ; ZAKOVSKA, A. ; Kasparkova J ; BALCAROVA, Z. ; KLEINWACHTER, V. ; Vrana, O. ; FARRELL, N. ; Brabec, V. . DNA Interactions of Bifunctional Dinuclear Platinum(II) Antitumor Agents.. European Journal of Biochemistry , v. 246, p. 508, 1997.
Rauter, H ; Di Domenico, R. ; Menta, E ; OLIVA, A. ; FARRELL, N. . Selective Platination of Biologically Relevant Polyamines. Linear Coordinating Spermidine and Spermine as Amplifying Linkers in Dinuclear Platinum Complexes.. Inorganic Chemistry , v. 36, p. 3919, 1997.
Bierbach, Ulrich ; FARRELL, N. . Modulation of Nucleotide Binding of Trans-Platinum(II) Complexes by Planar Ligands. A Combined Proton NMR and Molecular Mechanics Study.. Inorganic Chemistry , v. 36, p. 3657, 1997.
MELLISH, K. J. ; Y, Q. ; SCARSDALE, J. N. ; FARRELL, N. . Effect of Geometric Isomerism in Dinuclear Platinum Antitumor Complexes on the Rate of Formation and Structure of Intrastrand Adducts with Oligonucleotides.. Nucleic Acids Research , v. 25, p. 1265, 1997.
Kasparkova J ; Mellish, K. J ; Y, Q. ; Brabec, V. ; FARRELL, N. . Site-Specific d(GpG) Intrastrand Cross-Links Formed by Dinuclear Platinum Complexes. Bending and NMR Studies.. Biochemistry (Easton) , v. 35, p. 16705, 1996.
Matthews J B ; Adomat, H. ; FARRELL, N. ; King, P. ; Koch, C. ; Lord, E. ; Palcic, B. ; Poulin, N. ; Sangulin, J. ; Skov, K. A. . Immunocytochemical labeling of aerobic and hypoxic mammalian cells using a platinated derivative of EF5.. British Journal of Cancer , v. 74, p. S2000, 1996.
Y, Q. ; Bloemink MJ ; REEDIJK, J. ; HAMBLEY, T. W. ; FARRELL, N. . Dinuclear Platinum Complexes Form a Novel Intrastrand Adduct with d(GpG) - an anti-syn conformation of the macrochelate as observed by NMR and molecular modeling.. Journal of the American Chemical Society , v. 118, p. 9307, 1996.
Wu, P. ; KHARATISHVILI, M. ; Y, Q. ; FARRELL, N. . A Circular Dichroism Study of Ethidium Bromide Binding to Z-DNA Induced by Dinuclear Platinum Complexes.. Journal of Inorganic Biochemistry , v. 63, p. 9, 1996.
Y, Q. ; FARRELL, N. . Of Mononuclear And Dinuclear Platinum Tetraamine Cations With Guanosine 5'-monophosphate (5'-GMP) Studied By 15Nitrogen NMR Relaxation.. Inorganica Chimica Acta , v. 245, p. 265, 1996.
EBBIGHAUSEN, J. ; FARRELL, N. ; LOVQUIST, K. ; Oskarsson A . cis-Dichlorobis-[methylbenzylsulfoxide]platinum (II).. Acta Crystallographica. Section C, Crystal Structure Communications , v. 52, p. 1091, 1996.
Bierbach, Ulrich ; HAMBLEY, T. W. ; Roberts, J. D. ; FARRELL, N. . Oxidative Addition of the Dithiobis(formadinium) cation to Platinum(II) Chloro Am(m)ine Compounds: Studies on Structure, Spectroscopic Properties, Reactivity and Cytotoxicity of a New Class of Pt(IV) Complexes Exhibiting S-Thiourea Coordination.. Inorganic Chemistry , v. 35, p. 4865, 1996.
FARRELL, N. ; Appleton, T. G. ; Y, Q. ; Roberts, J. D. ; Fontes, A. P. Soares ; Skov, K. A. ; Wu, P. ; Zou, Y . Effects of Geometric Isomerism and Ligand Substitution in Bifunctional Dinuclear Platinum Complexes on Binding Properties and Conformational Changes in DNA.. Biochemistry (Easton) , v. 34, p. 15480-6, 1995.
YANG, D. ; van BOOM, S. ; REEDIJK, J. ; van Boom J. ; FARRELL, N. ; Wang Y . A novel DNA structure induced by the new dinuclear anticancer compound -(1,4-diaminobutane)-bis[trans-diamminechloroplatinum(II)] crosslinked to a GpC site in DNA.. Nature Structural Biology , v. 2, p. 577, 1995.
Y, Q. ; FARRELL, N. . Synthesis and Chemical Properties of a Heterodinuclear (Pt,Ru) DNA-DNA and DNA-Protein Crosslinking Agent.. Inorganic Chemistry , v. 34, p. 3573, 1995.
BERNAREGGI, A. ; TORTI, L. ; TOGNELLA, S. ; CESARANI, R. ; CARINI, M. ; DEPTA, G. ; CASETTA, B. ; FARRELL, N. ; FACINO, R. M. . . In vitro formation and characterization of cisplatin-glutathione adducts. Their in vivo absence following concomitant administration of cisplatin and glutathione to rats and cancer patients.. Journal of Chromatography. B , v. 669, p. 247, 1995.
Marples B ; Adomat, H. ; Billings, P. C. ; FARRELL, N. . Recognition of platinum-induced DNA damage by nuclear proteins: screening for mechanisms.. Anti-Cancer Drug Design , v. 9, p. 389-399, 1994.
Skov, K. A. ; Adomat, H. ; Doedee, M ; FARRELL, N. . Radiosensitizing and toxic properties of quinoline and nitroquinoline complexes of platinum [PtCl2(NH3)quinoline].. Anti-Cancer Drug Design , v. 9, p. 103, 1994.
Skov, K. A. ; Adomat, H. ; FARRELL, N. . Radiosensitization by nickel lapachol.. International Journal of Radiation Biology , v. 57, p. 947-958, 1993.
Y, Q. ; FARRELL, N. ; Valsecchi, M ; de Greco, L ; Spinelli, S . Multinuclear platinum-195 and nitrogen-15 magnetic resonance spectroscopic studies of the reaction of potassium trichloroammineplatinate with potassium iodide and amines.. Magnetic Resonance in Chemistry , v. 31, p. 920, 1993.
Zou, Y ; Van Houten B ; FARRELL, N. . Ligand effects in platinum binding to DNA. A comparison of DNA binding properties for cis- and trans-[PtCl2(amine)2] (amine = NH3, pyridine).. Biochemistry (Easton) , v. 32, p. 9632, 1993.
Kraker A J ; Hoeschele J D ; Elliott W L ; Showalter H D ; Sercel A D ; FARRELL, N. . Anticancer activity in murine and human tumor cell lines of bis(platinum) complexes incorporating straight-chain aliphatic diamine linker groups.. European Journal of Medicinal Chemistry , v. 35, p. 4526-4523, 1992.
Landi, J. ; Hacker, M. P. ; FARRELL, N. . Sulfoxides as leaving groups. Effect of sterically hindered aliphatic sulfoxides on the antitumor activity of chloro(substituted sulfoxide)(1,1-diaminomethylcyclohexane)platinum(II) nitrate.. Inorganica Chimica Acta , v. 202, p. 79, 1992.
Skov, K. A. ; FARRELL, N. . Radiosensitization by metal complexes of 4(5)-nitroimidazole. International Journal of Radiation Biology , v. 57, p. 947-958, 1990.
Skov, K. A. ; Adomat, H. ; Chaplin, D. J. ; FARRELL, N. . Toxicity of [PtCl2(NH3)L] in hypoxia; L = misonidazole or metronidazole. Anti-cancer drug design , v. 5, p. 121-128, 1990.
Roberts J D ; Van Houten B ; Y, Q. ; FARRELL, N. . Interaction of novel bis(platinum) complexes with DNA.. Nucleic Acids Research , v. 17, p. 9719-9723, 1989.
Richmond R C ; FARRELL, N. ; Curphey T J ; Mahtani H K. . Potentiation of radiation-induced bacterial cell killing by binuclear rhodium(II) complexes and their amines.. Radiation Research , v. 120, p. 416-429, 1989.
Richmond R C ; FARRELL, N. ; Mahtani H K. . Potentiation of radiation-induced bacterial cell killing by binuclear rhodium(II) carboxylates.. Radiation Research , v. 120, p. 403-415, 1989.
Hoeschele J D ; James, D ; FARRELL, N. ; Turner, W. R. ; Rithner, Christopher D. . Synthesis and characterization of diastereomeric (substituted iminodiacetato)(1,2-diaminocyclohexane)platinum(II) complexes.. Inorganic Chemistry , v. 27, p. 4106, 1988.
Skov, K. A. ; FARRELL, N. ; Adomat, H. . Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: radiosensitization and toxicity studies in vitro. Radiation Research , v. 112, p. 273-282, 1987.
Skov, K. A. ; FARRELL, N. . Binding mode of 2-amino-5-nitrothiazole (ANT) in platinum complexes, trans-[PtCl2(ANT)2], affects DNA binding, toxicity and radiosensitizing ability.. International journal of radiation biology and related studies in physics, chemistry, and medicine , v. 52, p. 289-297, 1987.
Skov, K. A. ; Adomat, H. ; Konway D C ; FARRELL, N. . Assessment of DNA binding of platinum-radiosensitizer complexes by inhibition of restriction enzymes. Chemico-Biological Interactions , v. 62, p. 117-129, 1987.
Chan, P. K. L. ; Skov, K. A. ; JAMES, B. R. ; FARRELL, N. . Chromosome-damaging activity of a ruthenium radiosensitizer, RuCl2(DMSO)2(4-nitroimidazole)2, in Chinese hamster ovary cells in vitro.. Chemico-Biological Interactions , v. 59, p. 247-254, 1986.
Chan, P. K. L. ; Skov, K. A. ; JAMES, B. R. ; FARRELL, N. . A new ruthenium radiosensitizer: RuCl2(DMSO)2(4-nitroimidazole)2.. International Journal of Radiation Oncology, Biology, Physics , v. 12, p. 1059-1063, 1986.
Gomez, M. V. ; FARRELL, N. . The effect of tityustoxin and ruthenium red on the release of acetylcholine from slices of cortex of rat brain.. Neuropharmacology , v. 24, p. 1103, 1985.
Alberding, Neil ; FARRELL, N. ; Crozier, E. D. . Examination of rhodium carboxylate antitumor agents complexed with nucleosides by extended x-ray absorption fine structure spectroscopy.. Journal of the American Chemical Society , v. 107, p. 384, 1985.
FARRELL, N. ; Williamson, J. ; McLaren, Diane J. M. . Trypanocidal and antitumor activity of platinum-metal and platinum-metal-drug dual-function complexes.. Biochemical Pharmacology , v. 33, p. 961-971, 1984.
FARRELL, N. ; De Oliveira, N. G. . Dimethyl sulfoxide-ruthenium complexes of adenine.. Inorganica Chimica Acta , v. 66, p. L61, 1982.
FARRELL, N. ; Neves, A. A. . Aryldiazonium complexes of ruthenium porphyrins.. Inorganica Chimica Acta , v. 54, p. L53, 1981.
FARRELL, N. ; Dolphin, D. H. ; James, D ; JAMES, B. R. . Reversible binding of dioxygen to ruthenium(II) porphyrins. Journal of the American Chemical Society , v. 100, p. 324, 1978.
Eaborn, C. ; FARRELL, N. ; Murphy, J. L. ; Pidcock, A. . Reactions of methyl fluorosulfonate and triethyloxonium tetrafluoroborate with metal complexes.. Journal of Organometallic Chemistry , v. 55, p. C68, 1973.
Kelland L R ; FARRELL, N. . Platinum-Based Drugs in Cancer Therapy. Humana Press, 2000.
FARRELL, N. (Org.) . Uses of Inorganic Chemistry in Medicine. , 1999.
FARRELL, N. ; UGO, R. ; JAMES, B. R. . Transition Metal Complexes as Drugs and Chemotherapeutic Agents. , 1989.

Outras produções

FARRELL, N. ; HEGMANS, A. ; ROBERTS, J. D. . Targeted Bisplatinum Polyamines as Pro-Drugs. 2003. (Patente).

FARRELL, N. . New Bisplatinum Complexes as Chemotherapeutic Agents. 2003. (Patente).

FARRELL, N. ; Menta, E ; Di Domenico, R. ; Spinelli, S . Bis-Platinum Complexes With Polyamine Ligands As Antitumor Agents. 2002. (Patente).

FARRELL, N. . Platinum Amine Sulfoxide Complexes. 2002. (Patente).

Re G ; Di Domenico, R. ; Spinelli, S ; FARRELL, N. . Multinuclear Cationic Platinum Complexes with Antitumor Activity. 2001. (Patente).

Skov, K. A. ; FARRELL, N. ; CHAPLIN, D. J. . Platinum Complexes with One Radiosensitizing Ligand. 2001. (Patente).

Skov, K. A. ; CHANG, P. K. ; JAMES, B. R. ; FARRELL, N. . Ruthenium Complexes Containing Tetramethylenesulphoxide and Nitroaromatic Ligands as Radiosensitizers. 2001. (Patente).

VALSECCHI, M. ; PAVESI, P. ; BUGATTI, C. ; Menta, E ; Spinelli, S ; FARRELL, N. . Trinuclear Cationic Platinum Complexes having Antitumor Activity and Pharmaceutial Compositions Containg them. 2000. (Patente).

FARRELL, N. . Transplatinum Complexes as Cytotoxic and Anticancer Agents. 2000. (Patente).

VALSECCHI, M. ; CONTI, M. ; de Greco, L ; BUGATTI, C. ; Menta, E ; Giuliani, F. C. ; Manzotti, C ; Spinelli, S ; FARRELL, N. . Trinuclear Cationic Platinum Complexes having Antitumor Activity and Pharmaceutical Compositions containing them. 2000. (Patente).

FARRELL, N. . Platinum Complexes with Sulfoxide Leaving Groups. 2000. (Patente).

FARRELL, N. ; KLOSTER, M. . High Affinity DNA Binding Compounds as Adjuvants in Antisense Technology. 1999. (Patente).

FARRELL, N. ; Bierbach, Ulrich . Water Soluble Transplatinum Complexes with Anti-Cancer Activity and Method of using same. 1999. (Patente).

FARRELL, N. ; Spinelli, S ; Valsecchi, M ; Menta, E . Bisplatinum (IV) Complexes. 1999. (Patente).

FARRELL, N. ; Bierbach, Ulrich . Platinum Complexes with Anti-viral Activity and Method of Using Same. 1998. (Patente).

FARRELL, N. ; Menta, E ; Di Domenico, R. ; Spinelli, S . New Bis-Platinum Complexes with Polymethylene Derivatives as Ligands having Antitumor Activity. 1998. (Patente).

FARRELL, N. . Trans Platinum (IV) Complexes. 1994. (Patente).

HOESCHELE, J. D. ; Y, Q. ; FARRELL, N. . Tri(Platinum) Complexes. 1993. (Patente).

FARRELL, N. ; WINOOSKI, M. P. ; HACKER, W. ; BURLINGTON, J. J. M. ; WINOOSKI, S. G. A. . Bis-Platinum Complexes as Chemotherapeutic Agents. 1989. (Patente).

Projetos de pesquisa

2003 - Atual

Platinum Metal Complexes as DNA-Protein Cross-Linking Agents, Descrição: This project aimed to understand the mechanism of cytotoxicity of novel transplatinum (TPA) complexes containing planar amines.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Nicholas Farrell - Coordenador.
2001 - Atual

Mechanistic Studies on New Platinum Clinical Agents - NIH, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Nicholas Farrell - Coordenador.
1997 - 2000

Dinuclear Metal Complexes as DNA-protein Cross-Linking Agents, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Nicholas Farrell - Coordenador.

Histórico profissional

Endereço profissional

Virginia Commonwealth University, Chemistry Department. , 1001 West Main Street, 23284-2006 - Richmond, - Estados Unidos - Caixa-postal: 842006, Telefone: (804) 8281298, Fax: (804) 8288599

Experiência profissional

1996 - 1996

University of Sydney New South Wales, Australia

Vínculo: Professor Visitante, Enquadramento Funcional: Foundation for Inorganic Chem, Regime: Dedicação exclusiva.

1993 - 1996

Virginia Commonwealth University

Vínculo: Professor Visitante, Enquadramento Funcional: Associate Professor, Carga horária: 40, Regime: Dedicação exclusiva.

Atividades

01/2005
Direção e administração, Chemistry Department, .,Cargo ou função, Chefe de Departamento.
01/1996
Pesquisa e desenvolvimento , Chemistry Department, .,Linhas de pesquisa
01/1996
Ensino, Quimica, Nível: Graduação,Disciplinas ministradas, Quimica Bioinorganica, Quimica Inorganica

1993 - 1994

University College Dublin

Vínculo: Professor Visitante, Enquadramento Funcional: Professor, Regime: Dedicação exclusiva.

1984 - 1993

University of Vermont, Burlington VT, USA

Vínculo: Professor Visitante, Enquadramento Funcional: Research Associate Professor, Carga horária: 40, Regime: Dedicação exclusiva.

1981 - 1982

Simon Fraser University

Vínculo: Professor Visitante, Enquadramento Funcional: Visiting Associate Professor, Carga horária: 40, Regime: Dedicação exclusiva.

1980 - 1980

Cambridge University

Vínculo: Professor Visitante, Enquadramento Funcional: Visiting Professor, Carga horária: 40, Regime: Dedicação exclusiva.

Outras informações:
With Prof. B.F.G. Johnson, under auspices of CNPq Brasil and British Council

1977 - 1984

Universidade Federal de Minas Gerais

Vínculo: Professor Visitante, Enquadramento Funcional: Associate Professor, Carga horária: 40, Regime: Dedicação exclusiva.

Outras informações:
Professor e Pesquisador na area de Quimica Inorganica