Laurent Claude Stéphane Rénia

Dr. Laurent Renia obteve o seu doutorado em 1991 na Universidade Pierre e Marie Curie em Paris, Franca, onte ele estudou a resposta imune contra a fase pre-eritrocitica da malaria. Ele continuou o seu trabalho em imunologia da malaria como pos-doutorado na New York University sob a supervisao do Dr. Victor Nussenzweig (1991-1992). Ele entao voltou para Paris em 1993 onde obteve uma posicao permanente como jovem pesquisador na French national of Institute of Health (INSERM) trabalhando em imunologia da malaria na INSERM Unit 313 no Hospital Pitie-Salpetriere em Paris. Ele se mudou para INSERM Unit 445 no Instituto Cochin em Paris onde comecou o seu proprio grupo em 1997. Entre 2001-2006, ele se tornou diretor de pesquisa em INSERM, co-diretor e diretor do Departamento de Imunologia no Instituto Cochin. Em 2007 ele se juntou ao Singapore Immunology Network em Cingapura para desenvolver novas ferramentas e abordagens, onde atraves de analise imunologica comparativa de individuos naturalmente e experimentalmente protegidos versus nao protegidos sera conduzida para identificar correlatos de protecao ou patologia contra infeccao pelo Plasmodium.

Informações coletadas do Lattes em 10/11/2022

Acadêmico

Formação acadêmica

Doutorado em Saude Publica

1988 - 1991

INSERM U313
Título: Humoral and cellular mechanisms against malaria liver stage.
Orientador: Dominique Mazier
Bolsista do(a): Ministère de la Recherche et de la Technologie.

Pós-doutorado

1991 - 1992

Pós-Doutorado. , New York University School of Medicine. , Bolsista do(a): Mac Arthur Foundation fellowship.

Orientou

Bruce Russell

Início: 2008; Singapore Immunology Network, Agency for Science Tecnology and Research;

Anne Charlotte Gruner

Início: 2008; Singapore Immunology Network, Agency for Science Tecnology and Research;

Rossarin Suwanarusk

Início: 2008; Singapore Immunology Network, Agency for Science Tecnology and Research;

Benoit Malleret

Início: 2008; Singapore Immunology Network, Agency for Science Tecnology and Research;

Carla Claser

Início: 2008; Singapore Immunology Network, Agency for Science Tecnology and Research;

Shanshan Wu Howland

Início: 2008; Singapore Immunology Network, Agency for Science Tecnology and Research;

Produções bibliográficas

ROTTMAN, M. ; SOUDAIS, C. ; VOGT, G. ; RÉNIA, L. ; EMILE, J.F. ; DECALUWE, H. ; GAILLARD, J.L. ; CASANOVA, J.L. . IFN-gama mediates the rejection of hematopoietic stem cells in IFN-gama R1-deficient hosts.. PLoS Medicine , v. 5, p. 152-163, 2008.
LENGAGNE, R. ; GRAFF-DUBOIS, S. ; GARCETTE, M. ; RÉNIA, L. ; KATO, M. ; GUILLET, J.G. ; ENGELHARD, V. H. ; AVRIL, M.F. ; ABASTADO, J.P. ; PREVOST-BLONDEL, A. . Distinct role for CD8 T cells toward cutaneous tumors and visceral metastases.. Journal of Immunology (Baltimore) , v. 180, p. 130-137, 2008.
TOGBE, D. ; de SOUSA, P.L. ; FAUCONNIER, M. ; BOISSAY, V. ; FICK, L. ; SCHEU, S. ; PFEFFER, K. ; MENARD, R. ; GRAU, G. E. ; DOAN, B.T. ; BELOEIL, J.C. ; RÉNIA, L. ; HANSEN, A.M. ; BALL, H.J. ; HUNT, N.H. ; RUFFEL, B. ; QUESNIAUX, V.F.J. . Both functional LTb receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One , v. 3, p. 1-12, 2008.
GRUNER, A.C. ; MAUDUIT, M. ; TEWARI, R. ; ROMERO, J.F. ; DEPINAY, N. ; KAYIBANDA, M. ; LALLEMAND, E. ; CHAVATTE, J.M. ; CRISANTI, A. ; SINNIS, P. ; MAZIER, D. ; CORRADIN, G. ; SNOUNOU, G. ; RÉNIA, L. . Sterile protection against malaria is independent of immune responses to the circunsporozoite protein. PLos One , v. 2, p. 1-6, 2007.
BONGLEN, S.E. ; TORGLER, R. ; ROMERO, J.F. ; RÉNIA, L. ; CORRADIN, G. . Plasmodium berguei - infected primary hepatocytes process and present the circunsporozoite protein to specific CD8 T cells in vitro. Journal of Immunology (Baltimore) , v. 178, p. 7054-7063, 2007.
VIGARIO, A.M. ; BELNOUE, E. ; GRUNER, A.C. ; MAUDUIT, M. ; KAYIBANDA, M. ; DESCHEMIN, J.C. ; MARUSSIG, M. ; SNOUNOU, G. ; MAZIER, D. ; GRESSER, I. ; RÉNIA, L. . Recombinant human IFN-a inhibits cerebral malaria and reduces parasite burden in mice.. Journal of Immunology (Baltimore) , v. 178, p. 6416-6422, 2007.
SOULARD, V. ; ROLAND, J. ; SELLIER, C. ; GRUNER, A.C. ; LEITE-DE-MORAES, M. ; FRANETICH, J.F. ; RÉNIA, L. ; CAZENAVE, P.A. ; PIED, S. . Primary infection C57BL/6 mice with Plasmodium yoelii induces a heterogeneous NKT cells. Infection and Immunity , v. 75, p. 2511-2522, 2007.
IYER, J. ; GRUNER, A.C. ; SNOUNOU, G. ; RÉNIA, L. ; PREISER, P.R. . Invasion of host cells by malaria parasites: a tale of two protein families.. Molecular Microbiology , v. 65, p. 231-249, 2007.
SNOUNOU, G. ; RÉNIA, L. . The vaccine is dead - long live the vaccine. Trends in Parasitology , v. 23, p. 130-132, 2007.
LENA, G. ; LALLEMAND, E. ; GRUNER, A.C. ; BOEGLIN. J. ; ROUSSEL, S. ; SCHAFFNER, A.P. ; AUBRY, A. ; FRANETICH, J.F. ; MAZIER, D. ; LANDAU, I. ; BRIAND, J.P. ; DIDIERJEAN, C. ; RÉNIA, L. ; GUICHARD, G. . 1,3,5-Triazepan-2,6-diones as structurally diverse and conformationally constrained dipeptide mimetics. Identification of malaria liver stage inhibitors from small pilot library.. Chemistry - A European Journal (1521-3765) , v. 12, p. 8498-8512, 2006.
BABAYAN, S.A. ; ATTOUT, T. ; HARRIS, A. ; TAYLOR, M.D. ; Le GOFF, L. ; VUONG, P.N. ; RÉNIA, L. ; ALLEN, J.E. ; BAIN, O. . Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages.. International Journal for Parasitology , v. 36, p. 903-914, 2006.
MOROSAN, S. ; HEZ-DEROUBAIX, S. ; LUNEL, F. ; RÉNIA, L. ; GIANNINI, C. ; VAN ROOIJEN, N. ; BATTAGLIA, S. ; BLANC, C. ; ELING, W. ; SAUERWEIN, R. ; HANNOUN, L. ; BELGHITI, J. ; BRECHOT, C. ; KREMSDORF, D. ; DRUILHE, P. . Liver-stage development of Plasmodium falciparum in a humanized mouse model.. The Journal of Infectious Diseases , v. 193, p. 996-1004, 2006.
RÉNIA, L. ; MARANON, C. ; HOSMALIN, A. ; GRUNER, A.C. ; SILVIE, O. ; SNOUNOU, G. . Do apoptotic malaria infected hepatocytes initiate protective immune responses?. The Journal of Infectious Diseases , v. 193, p. 163-164, 2006.
RÉNIA, L. ; POTTER, S.M. . Co-infection of malaria with HIV: an immunological perspective.. Parasite Immunology , v. 28, p. 589-595, 2006.
RÉNIA, L. ; GRUNER, A.C. ; MAUDUIT, M. ; SNOUNOU, G. . Vaccination against malaria with live parasites.. Expert Review of Vaccines , v. 5, p. 473-481, 2006.
RÉNIA, L. ; POTTER, S.M. ; MAUDUIT, M. ; ROSA, D.S. ; KAYIBANDA, M. ; DESCHEMIN, J.C. ; SNOUNOU, G. ; GRUNER, A.C. . Pathogenic T cells in cerebral malaria.. International Journal for Parasitology , v. 36, p. 547-554, 2006.
REYNAUD, D. ; RAVET, E. ; TITEAUX, M. ; MAZURIER, F. ; RÉNIA, L. ; DUBART-KUPPERSCHMIT, A. ; ROMEO, P.H. ; PFLUMIO, F. . SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment. Blood (Philadelphia) , v. 106, p. 2318-2328, 2005.
KUMKHAEK, C. ; PHRA-EK, K. ; RÉNIA, L. ; SINGHASIVANON, P. ; LOOAREESUWAN, S. ; HIRUNPETCHARAT, C. ; WHITE, N.J. ; BROCKMAN, A. ; GRUNER, A.C. ; LEBRUN, N. ; ALLOUECHE, A. ; NOSTEN, F. ; KHUSMITH, S. ; SNOUNOU, G. . Are extensive T-cell epitope polymorthisms in a leading sporozoite vaccine selected by immune pressure?. Journal of Immunology (Baltimore) , v. 175, p. 3935-3939, 2005.
ENGWERDA, C. ; BELNOUE, E. ; GRUNER, A.C. ; RÉNIA, L. . Experimental models of cerebral malaria. In: Immunology of Malaria. Current Topics in Microbiology and Immunology , v. 297, p. 103-143, 2005.
COMBES, V. ; de SOUZA, J.B. ; RÉNIA, L. ; GRAU, G.E. . Cerebral malaria: which parasite? which model?. Drug Discovery Today , v. 2, p. 141-147, 2005.
SNOUNOU, G. ; GRUNER, A.C. ; MULLER-GRAF, C.D.M. ; MAZIER, D. ; RÉNIA, L. . The Plasmodium sporozoite survives RTS,S vaccination.. Trends in Parasitology , v. 24, p. 456-461, 2005.
VOZA, T. ; VIGARIO, A.M. ; BELNOUE, E. ; GRUNER, A.C. ; DESCHEMIN, J.C. ; VUONG, P.N. ; KAYIBANDA, M. ; DELMAS, F. ; FRANKE-FAYARD, B. ; JANSE, C.J. ; WATERS, A.P. ; LANDAU, I. ; SNOUNOU, G. ; RÉNIA, L. . Species-specific abrogation of experimental cerebral malaria induced by Plasmodium berguei ANKA in co-infected mice.. Infection and Immunity , v. 73, p. 4077-4786, 2005.
IMWONG, M. ; PUKRITTAYAKAMEE, S. ; GRUNER, A.C. ; RÉNIA, L. ; LETOURNEUR, F. ; LOOAREESUWAN, S. ; WHITE, N.J. ; SNOUNOU, G. . Practical PCR genotyping protocols for Plasmodium vivax using pvcs and pvmsp1.. Malaria Journal (Online) , v. 4, p. 20-26, 2005.
LOU, D.Q. ; LESBORDES, J.C. ; NICOLAS, G. ; VIATTE, L. ; BENNOUN, M. ; VAN ROOIJEN, N. ; KAHN, A. ; RÉNIA, L. ; VAULONT, S. . Iron- and inflammation-induced hepcidin gene expression in vivo are not mediated by Kupffer cells. Hepatology (Baltimore) , v. 41, p. 1056-1064, 2005.
SINGH, N. ; PREISER, P.R. ; RÉNIA, L. ; BALU, B. ; BARNWELL, J. ; BLAIR, P. ; JARRA, W. ; VOZA, T. ; LANDAU, I. ; ADAMS, J.H. . Conservation and developmental control of alternative splicing in maebl among malaria parasites. Journal of Molecular Biology , v. 343, p. 589-599, 2004.
McROBERT, L. ; PREISER, P.R. ; SHARP, S. ; JARRA, W. ; KAVIRATNE, M. ; TAYLOR, M.C. ; RÉNIA, L. ; SUTHERLAND, C.J. . Distinct trafficking and localisation of STEVOR proteins in three life-cycle compartments of Plasmodium falciparum. Infection and Immunity , v. 72, p. 6597-6662, 2004.
BELNOUE, E. ; GUETTIER, C. ; KAYIBANDA, M. ; LE ROND, S. ; CRAIN-DENOYELLE, A.M. ; ZIOL, M. ; FRADELIZI, D. ; RÉNIA, L. ; VIGUIER, M. . Regression of establhished liver tumor induced by monoepitopic peptide-based immunotherapy. Journal of Immunology (Baltimore) , v. 173, p. 4882-4888, 2004.
GRUNER, A.C. ; SNOUNOU, G. ; FULLER, K. ; JARRA, W. ; RÉNIA, L. ; PREISER, P.R. . The PY235 proteins: Glimpses into versatility of multigene families. Microbes and Infection , v. 6, p. 281-287, 2004.
PREISER, P.R. ; RÉNIA, L. ; SINGH, N. ; BALU, B. ; JARRA, W. ; VOZA, T. ; KANEKO, O. ; BLAIR, P. ; TORRII, M. ; LANDAU, I. ; ADAMS, J.H. . Antibodies against MAEBL inhibits sporozoite development in vitro. Infection and Immunity , v. 72, p. 3604-3608, 2004.
LENGAGNE, R. ; Le GAL, F.A. ; GARCETTE, M. ; FIETTE, L. ; AVE, P. ; KATO, M. ; BRIAND, J.P. ; MASSOT, C. ; NAKASHIMA, I. ; RÉNIA, L. ; GUILLET, J.G. ; PREVOST-BLONDEL, A. . Spontaneous vitiligo in an animal model for human melanoma: role of tumor-specific CD8 T cells. Cancer Research , v. 64, p. 1496-1501, 2004.
BELNOUE, E. ; COSTA, F.T.M. ; FRANKENBERG, T. ; VIGARIO, A.M. ; VOZA, T. ; LEROY, N. ; RODRIGUES, M.M. ; LANDAU, I. ; SNOUNOU, G. ; RÉNIA, L. . Protective T cell responses against malaria liver stages after vaccination with live sporozoites under chloroquine treatment. Journal of Immunology (Baltimore) , v. 172, p. 2487-2495, 2004.
SILVIE, O. ; FRANETICH, J.F. ; RÉNIA, L. ; MAZIER, D. . Malaria sporozoites: migrating for a living. Trends in Molecular Medicine , v. 10, p. 97-99, 2004.
KUMKHAEK, C. ; PHRA-EK, K. ; SINGHASIVANON, P. ; LOOAREESUWAN, S. ; HIRUNPETCHARAT, C. ; BROCKMAN, A. ; GRUNER, A.C. ; LEBRUN, N. ; RÉNIA, L. ; NOSTEN, F. ; SNOUNOU, G. ; KHUSMITH, S. . A survey of the Th2R and Th3R allelic variants in the circumsporozoite protein gene of Plasmodium falciparum parasites from western Thailand. Southeast Asian Journal of Tropical Medicine and Public Health , v. 35, p. 281-287, 2004.
GRUNER, A.C. ; SNOUNOU, G. ; BRAHIMI, K. ; LETOURNEUR, F. ; RÉNIA, L. ; DRUILHE, P. . Pre-erythrocytic antigens of Plasmodium falciparum: from rags to riches.. Trends in Parasitology , v. 19, p. 74-78, 2003.
BABAYAN, S.A. ; UNGEHEUER, M.N. ; MARTIN, C. ; ATTOUT, T. ; BELNOUE, E. ; SNOUNOU, G. ; RÉNIA, L. ; KORENAGA, M. ; BAIN, O. . Resistance and susceptibility to filarial infection with Litomosoides sigmodontis are associated with early differences in parasite development and in localized immune reactions.. Infection and Immunity , v. 71, p. 6820-6830, 2003.
BELNOUE, E. ; COSTA, F.T.M. ; VIGARIO, A.M. ; VOZA, T. ; GONNET, F. ; LANDAU, I. ; VAN ROOIJEN, N. ; MACK, M. ; KUZIEL, W.A. ; RÉNIA, L. . Chemokine receptor CCR2 is not essential for the development of experimental filarial. Infection and Immunity , v. 101, p. 4259-4269, 2003.
BELNOUE, E. ; KAYIBANDA, M. ; DESCHEMIN, J.C. ; VIGUIER, M. ; MACK, M. ; KUZIEL, W.A. ; RÉNIA, L. . CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood (Philadelphia) , v. 101, p. 4253-4259, 2003.
TOURNEUR, L. ; MISTOU, S. ; MICHIELS, F.M. ; DEVAUCHELLE, V. ; RÉNIA, L. ; FEUNTEUN, J. ; CHIOCCHIA, G. . Loss of FADD protein results in a biased Fas signaling pathway and correlates with the tumoral status development of thyroid follicular cells. Oncogene (Basingstoke) , v. 22, p. 2795-2804, 2003.
IMWONG, M. ; PUKRITTAYAKAMEE, S. ; RÉNIA, L. ; LETOURNEUR, F. ; CHARLIEU, J.P. ; LEARTSAKULPANICH, U. ; LOOAREESUWAN, S. ; WHITE, N.J. ; SNOUNOU, G. . Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure. Antimicrobial Agents and Chemotherapy , v. 47, p. 1514-1521, 2003.
SILVIE, O. ; RUBINSTEIN, E. ; FRANETICH, J.F. ; PRENANT, M. ; BELNOUE, E. ; RÉNIA, L. ; HANNOUN, L. ; ELING, W. ; LEVY, S. ; BOUCHEIX, C. ; MAZIER, D. . Hepatocyte CD81 is required for Plasmodium falciparum and P. yoelii sporozoite infectivity. Nature Medicine , v. 9, p. 93-96, 2003.
BELNOUE, E. ; POTTER, S.M. ; ROSA, D.S. ; MAUDUIT, M. ; GRUNER, A.C. ; KAYIBANDA, M. ; MITCHELL, A.J. ; HUNT, N.H. ; RÉNIA, L. . IFN-gamma is responsible for migration and intravascular sequestration of pathogenic CD8 T cell to the brain during experimental cerebral malaria.. Parasite Immunology , 2008.
MAZIER, D. ; RÉNIA, L. ; SNOUNOU, G. . A pre-emptive strike against malaria: Attacking the fleeting and stealthy hepatic forms.. Nature Reviews. Drug Discovery , 2008.
BUFFET, P.A. ; BRIAND, V. ; THELLIER, M. ; RÉNIA, L. ; DANIS, M. ; MAZIER, D. . Intermittent preventive treatment to children (IPRc) in areas of low malaria endemicity:firebreak or fire trap?. Trends in Parasitology , 2008.
RÉNIA, L. . Protective immunity against malaria liver stage.. Parasite (Paris) , 2008.

Histórico profissional

Endereço profissional

Biomedical Sciences Institutes. , Laboratory of Malaria Immunobiology, 8A Biomedical Grove Immunos Building #03-15, 138648 - Cingapura, - Cingapura, URL da Homepage: