Reiner Ludwig Gentz

Possui doutorado em Biologia Molecular pela Universidade de Heildelberg-Alemanha (1984). Pos-Doutorado pelo Roche Institute of Molecular Biology. Mais de vinte anos de experiencia em expressao e purificacao de proteinas terapeuticas e anticorpos. Group-Leader na Hoffman La Roche onde desenvolveu metodos de expressao e purificacao de proteinas (histidine-tag). Foi Senior Vice-Presidente do Depto. de Desenvolvimento de Proteinas na Human Genome Sciences (EUA) sendo responsavel pela producao de proteinas e anticorpos para ensaios clinicos. Coordenador responsavel pelo design e construcao de plantas de manufatura clinica de proteinas terapeuticas e anticorpos. Responsavel pelos laboratorios de Cultura de Celulas, Fermentacao, Purificacao, Formulacao e Estabilidade e Desenvolvimento Analitico.

Informações coletadas do Lattes em 10/11/2022

Acadêmico

Formação acadêmica

Doutorado em Biologia Molecular

1981 - 1984

University of Heidelberg
Título: Bioliogia Molecular
Orientador: H Bujard

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Espanhol

Compreende Pouco, Fala Pouco, Lê Razoavelmente, Escreve Pouco.

Português

Compreende Razoavelmente, Fala Razoavelmente, Lê Bem, Escreve Bem.

Alemão

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Produções bibliográficas

DECKERS, M. ; SMITS, P. ; KARPERIEN, M ; NI, J. ; TYLZANOWSKI, P. ; FENG, T. ; PARMELEE, D. ; ZHANG, J. ; BOUFFARD, E. ; GENTZ, R. L. ; LOWIK, C. ; MERREGAERT, J. . Recombinat human extracellur matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro. Bone (New York) , v. 28, p. 14-20, 2002.
OREN, D.A. ; LI, Y. ; VOLOVIK, Y. ; MORRIS, T. ; DHARIA, C ; DAS, K. ; GENTZ, R. L. ; ARNOLD, E. . Structural Basic of BLyS receptor recognition.. Nature Structural Biology , v. 9, p. 288-92, 2002.
MIGONE, T.S. ; ZHANG, J. ; LOO, X. ; ZHUANG, L. ; CHEN, C.H. ; B.HU, ; HONG, J.S. ; PERRY, J. W. ; CHEN, C. ; HU, B. ; CHEN, S. ; ZHOU, J. ; CHO, Y. ; GENTZ, R. L. . TL 1A is a TNF- like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator.. Immunity (Cambridge) , v. 16, p. 479-92, 2002.
RAJARATHNAM, K. ; LI, Y. ; ROHRER ; GENTZ, R. L. . Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine.. Journal of Biological Chemistry (Online) , v. 276, p. 4909-16, 2001.
HAN, Z. ; NI, J. ; SMITS, P. ; UNDERHILLL, C. ; ZIE, B. ; CHEN, Y ; LIU, N. ; TYLZANOWSKI, P. ; PARMELEE, D. ; DING, I. ; GAO, F. ; GENTZ, R. L. ; HUYLEBROECK, D. . Extracellular matrix protein 1 (ECMI) has angoigenic proterties and is expressed by breast tumor cells.. The FASEB Journal , v. 15, p. 988-94, 2001.
ALBERT, T. ; LEMAIRE, M. ; GENTZ, R. L. ; TIMMERS, H. . Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.. Nucleic Acids Research , v. 28, p. 809-817, 2000.
DENIU, P. ; RADMAN, D. ; JAWORSKI, E.M ; GENTZ, R. L. ; SU, J. ; OLSEN, H. . Development of human stanniocalcin radioimmunoassay: serum and tissue hormone levels and pharmacokinetics in the rat.. Molecular and Cellular Endocrinology , v. 162, p. 131--44, 2000.
ZHAI, Y. ; NI, J. ; JIANG, G. ; LU, J. ; XING, L. ; LINCOLN, C. ; CARTER, K. ; JANAT, F. ; KOZAK, D. ; XU, S. ; ROJAS, L. ; AGGARWAL, B. ; RUBEN, S. ; LI, L. ; GENTZ, R. L. . VEGI, a novel cytokine of the tumor necrosis factor family, is an angio-genesis inhibitor that suppresses the growth of colon carcinomas in vivo.. The FASEB Journal , v. 13, p. 181-189, 1999.
KONG, E. ; CHEN, M. ; GENTZ, R. L. ; ZHANG, J. . Cell growth and protein formation on varous microcarriers.. Cytotechnology (Dordrecht) , v. 29, p. 149-156, 1999.
KONG, D. ; CARDAK, S. ; CHEN, M. ; GENTZ, R. L. ; ZHANG, J. . High cell density and productivity culture of Chinese hamster ovary cells in a fluidized bed bioreactor.. Cytotechnology (Dordrecht) , v. 29, p. 215-220, 1999.
XIAO, G. ; LUI, Y.E. ; GENTZ, R. L. ; SANG, Q. ; NI, J. ; GOLDBERG, I. ; SHI, E. . Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells.. Proceedings of the National Academy of Sciences of the United States of America , v. 30, p. 3700-3705, 1999.
ZHANG, J. ; COLLINS, A. ; CHEN, M. ; KNYAZEV, I. ; GENTZ, R. L. . High-density perfusion culture of insect cells with a biosep ultrasonic filter.. Biotech Patent News , v. 59, p. 351-359, 1998.
WANG, C. ; NI, J. ; JIANG, T. ; HSU, M. ; DUGICH-DJORDJEVIC, M. ; FENG, L. ; ZHANG, M. ; MEI, L. ; GENTZ, R. L. ; LU, B. . Cloning and characterization of glial cell line-derived neurotrophic factor receptor-B: A novel receptor for members of glial cell line-derived neutrophic factor family of neurotrophic factors.. Neuroscience , v. 83, p. 07-14, 1998.
ZHANG, J. ; AFONSO, P. ; THOTAKURA, R. ; SU, J. ; BURGIN, M. ; PARMELEE, D. ; COLLINS, A. ; OELKUCT, M. ; GAFFNEY, S. ; GENTZ, S. ; RADMAN, D. ; WAGNER, G. ; GENTZ, R. L. . Expression, Purification, and Biossay of Human Stanniocalcin from Baculovirus-Infected Insect Cells and Recombinant CHO Cells.. Protein Expression and Purification , v. 12, p. 390-398, 1998.
DENIU, P. ; OLSEN, H. ; GENTZ, R. L. ; WAGNER, G. . Immunolocalization of stanniocalcin in human kidney. Molecular and Cellular Endocrinology , v. 137, p. 155-159, 1998.
CARVALHO, A. F. ; SANTOS, J. R. ; GENTZ, R. L. ; BONJARDIM, C. A. ; GOLGHER, R. R. ; FERREIRA, P.C.P ; KROON, E. G. . Culture of human amniotic cells: a system to study interferon production.. Placenta (Eastbourne) , v. 19, p. 307-314, 1998.
KWON, B. ; WANG, S. ; UDAGAWA, N. ; HARIDAS, V. ; LEE, Z. ; KIN, K. ; OH, K. ; GREENE, J. ; LI, Y. ; SU, J. ; GENTZ, R. L. ; AGGARWAL, B. ; NI, J. . TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibrolast proliferation and inhibits osteoclastogenesis and bone resorption.. The FASEB Journal , v. 12, p. 845-854, 1998.
LANGLEY, R. ; LEUNG, E. ; MORRIS, C. ; BERG, R. ; MCDONALD, M. ; WEAVER, A. ; PARRY, D. ; NI, J. ; SU, J. ; GENTZ, R. L. ; SPURR, N. ; KRISSANSEN, G. . Identification of Multiple Forms of 180-kDa Ribosome Receptor in Human Cells.. DNA and Cell Biology , v. 17, p. 449-460, 1998.
ZHAI, Y. ; GUO, R. ; HSU, T. ; YU, G. ; NI, J. ; KWON, B. ; JIANG, G. ; LU, J. ; TAN, J. ; UGUSTUS, M. ; CARTER, K. ; ROJAS, L. ; ZHU, F. ; LINCOLN, C. ; GENTZ, R. L. . LIGHT, A novel ligand for lymphotoxinβ receptor andTR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer.. Journal of Clinical Investigation , v. 102, p. 1142-1151, 1998.
CORNISH, A. ; FREEMAN, S. ; FORBES, G. ; NI, J. ; ZHANG, M. ; CEPEDA, M. ; GENTZ, R. L. ; AUGUSTUS, M. ; CARTER, K. ; CROCKER, P. . Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.. Blood (Philadelphia) , v. 92, p. 2123-2132, 1998.
NI, J. ; FERNANDEZ, A.F. ; DANIELSSON, L. ; CHILLAKURU, R. ; ZHANG, J. ; GRUBB, A. ; SU, J. ; GENTZ, R. L. ; ABRAHAMSON, M. . Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor.. Journal of Biological Chemistry (Online) , v. 273, p. 24797-24804, 1998.
PAN, G. ; OROURKE, K. ; H.P.HOHMANN, ; CHINNAIYAN, A. ; GENTZ, R. L. ; EBNER, R. ; NI, J. ; DIXIT, V. . The receptor for the Cytotoxic Ligand TRAIL.. Science , v. 276, p. 111-113, 1997.
NI, J. ; ABRAHAMSON, M. ; ZHANG, M. ; FERNANDEZ, M. ; A.GRUBB, ; J.SU, ; YU, G. ; LI, Y. ; PARMELEE, D. ; XING, L. ; COLEMAN, T. ; LIMA, S. ; THOTAKURA, R. ; HESSELBERG, M. ; GENTZ, R. L. . Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins.. JBCC. Jornal Brasileiro de Ciências da Comunicação , v. 272, p. 10853-10858, 1997.
KWON, B. ; OH, K. ; LEE, Z. ; KIM, K. ; KIM, M. ; NI, J. ; GENTZ, R. L. ; YU, G. ; YOUNG, P. ; TRUNEH, A. ; HARROP, J. ; LYN, S. ; TAN, K. . A newly identified member of tumor necrosis factor receptor superfamily shows a wide tissue distribution with multiple forms and T cell stimulatory activities.. JBCC. Jornal Brasileiro de Ciências da Comunicação , v. 272, p. 14272-14276, 1997.
PATEL, V. ; KREIDER, B. ; LI, Y. ; LI, H. ; LEUNG, K. ; SALCEDO, T. ; NARDELLI, B. ; GENTZ, S. ; THOTAKURA, R. ; PARMELEE, D. ; GENTZ, R. L. ; GAROTTA, G. . Molecular and Functional Characterization of two Novel Human C-C Chemokines as Inhibitors os Two Distinct Classes of Mveloid Progenitors.. Journal of Experimental Medicine , v. 185, p. 1163-1172, 1997.
COLEMAN, T. ; PARMELEE, D. ; THOTAKURA, R. ; NGUYEN, N. ; GENTZ, S. ; GENTZ, R. L. . Production and purification of novel secreted human proteins. Gene (Amsterdam) , v. 190, p. 163-171, 1997.
S.HU, ; VINCENZ, C. ; NI, J. ; GENTZ, R. L. ; DIXIT, V. . I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1-and CD-95-induced apoptosis.. JBCC. Jornal Brasileiro de Ciências da Comunicação , v. 272, p. 17255-17257, 1997.
SHI, E. ; NI, J. ; XIAO, G. ; LIU, Y. ; FUCHS, A. ; YU, G. ; SU, J. ; COSGROVE, J. ; XING, L. ; ZHANG, M. ; LI, J. ; AGGARWAL, B. ; MEAGER, A. ; GENTZ, R. L. . Antitumor Activity of the Novel Human Breast Cancer Growth Inhibitor, Mammary-derived Growth Inhibitor-related Gene, MRG1.. Cancer Research , v. 57, p. 3084-3091, 1997.
HU, J. ; HASTINGS, G. ; CHERRY, S. ; GENTZ, R. L. ; RUBEN, S. ; COLEMAN, T. . A novel regulatory function of proteolytically cleaved VEGF-2 for vascular endothelial and smooth muscle cells.. The FASEB Journal , v. 11, p. 498-504, 1997.
PAN, G. ; NI, J. ; Y.F.WEI, ; YU, G. ; GENTZ, R. L. ; DIXIT, V. . An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science , v. 277, p. 815-818, 1997.
FERNANDES, A. ; HERRERA, E. ; MAYRINK, W. ; GAZZINELLI, R. ; LIU, W. ; COSTA, C. ; TAVARES, C. ; MELO, M. ; MICHALICK, M. ; GENTZ, R. L. ; NASCIMENTO, E. . Immune responses induced by a Leishmania (Leishmania) amazonensis recombinat antigem in mice and lymphocytes from vaccinated subjects.. Revista do Instituto de Medicina Tropical de São Paulo , v. 39, p. 71-78, 1997.
KNAAP, J. V. D. ; BORST, J. ; VLIET, P. V. D. ; GENTZ, R. L. ; TIMMERS, H. . Cloning of the cDNA for the TATA-binding protein-associated factor 170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila.. Proceedings of the National Academy of Sciences of the United States of America , v. 94, p. 11827-11832, 1997.
FENG, G. ; OUYANG, Y. ; HU, D. ; SHI, Z. ; GENTZ, R. L. ; NI, J. . Grap Is a Novel SH3-SH2-SH3 Adaptor Protein That Couples Tyrosine Kinases to the Ras Pathway.. Journal of Biological Chemistry (Online) , v. 271, p. 12129-12132, 1996.
MUZIO, M. ; CHINNAIYAN, A. ; OROURKE, K. ; SCHEVCHENKO, A. ; NI, J. ; SCAIFE, J. ; J.BRETZ, ; ZHANG, M. ; GENTZ, R. L. ; MANN, M. ; KRAMMER, P. ; PETER, M. ; DIXIT, V. . FLICE, a Novel FADD-Homologous ICE/CED-3-likes Protease, Is Resruited to the CD95 (Fas/APO-1) Death-inducing Signaling Complex.. Cell , v. 85, p. 817-827, 1996.
CHINNAIYAN, A. ; OROURKE, K. ; YU, G. ; LYONS, R. ; GARG, M. ; DUAN, D. ; ZING, L. ; GENTZ, R. L. ; NI, J. ; DIXIT, V. . Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95.. Science (Online) , v. 274, p. 990-992, 1996.
CROWE, J. ; DOBELI, H. ; GENTZ, R. L. ; HOCHULI, E. ; STUBER, D. ; HENCO, K. . 6xHis-Ni-NTA chromoatography as a superior technique in recombinant protein expression/purification.. Methods in Molecular Biology (Clifton) , v. 31, p. 371-387, 1994.
OZMEN, L. ; FOUNTOULAKIS, M. ; GENTZ, R. L. ; GAROTTA, G. . Immunomodulation with soluble IFNy receptor: preliminary study.In: International review experimental pathology.. Food Science and Technology / Lebensmittel-Wissenschaft + Technologie , v. 34B, p. 137-147, 1993.
DARCY, A. ; BANNER, D. ; JANES, W. ; WINKLER, F. ; LOTSCHER, H. ; SCHONFELD, H. ; ZULAUF, M. ; GENTZ, R. L. ; LESSLAUER, W. . Crystalization and preliminary crystallographic analysis of TNFβ and a TNFβ/55kDa TNF receptor complex.. Journal of Molecular Biology , v. 229, p. 555-557, 1993.
KALINA, U. ; OZMEN, L. ; PADOVA, K. ; GENTZ, R. L. ; GAROTTA, G. . The human IFNγ receptor acessory factor encoded by chromosome 21 transduces the signal for the induction of 2', 5' -A-oligo-synthetase, resistance to virus cytopathic effect and MHC class I antigens.. Journal of Virology , v. 67, p. 1702-1706, 1993.
ROTHE, J. ; BLUTHMANN, H. ; GENTZ, R. L. ; LESSLAUER, W. ; STEINMETZ, M. . Genomic organization and promoter function of the murine tumor necrosis factor receptor β gene.. Molecular Immunology , v. 30, p. 165-175, 1993.
OSTADE, X. V. ; VANDENABEELE, P. ; EVERAERDT, B. ; LOTSCHER, H. ; GENTZ, R. L. ; BROCKHAUS, M. ; LESSLAUER, W. ; TAVERNIER, J. ; BROUCKAERT, P. ; FIERS, W. . Human TNF mutants with selective activity on the p55 receptor.. Nature (London) , v. 361, p. 266-269, 1993.
OZMEN, L. ; GRIBAUDO, G. ; FOUNTOULAKIS, M. ; GENTZ, R. L. ; LANDOLFO, S. ; GAROTTA, G. . Mouse soluble IFNγ receptor as IFNγ inhibitor: Distribution, antigenicity and activity after injection in mice.. Journal of Immunology (Baltimore) , v. 150, p. 2698-2705, 1993.
BANNER, D. ; DARCY, A. ; JANES, W. ; GENTZ, R. L. ; SCHONFELD, H. ; LOTSCHER, H. ; LESSLAUER, W. . Crystal of the soluble human 55 kDa TNF receptor/human TNFβ complex. Implication for TNF receptor activation.. Biological Research , v. 73, p. 431-445, 1993.
NOVELLI, F. ; GIOVARELLI, M. ; GENTZ, R. L. ; ZUCCA, M. ; PIERRO, F. ; GAROTTA, G. ; FORNI, G. . Modulation of interferon-γ receptor during human T lymphocyte alloactivation.. European Journal of Immunology , v. 23, p. 1226-1231, 1993.
GENTZ, R. L. ; BROCKHAUS, M. ; LOTSCHER, H. ; LESSLAUER, W. . Both Tumor necrosis factor receptors types mediate proliferation signals in human mononuclear cell activation.. European Journal of Immunology , v. 149, p. 311-317, 1992.
GRZESIEK, S. ; DOBELI, H. ; GENTZ, R. L. ; GIANNI, G. ; LABHARDT, A. ; BAX, A. . 1H, 13C, and 15N NMR backbone assignements and seconday struture of human interferon.. Journal of Biochemistry , v. 31, p. 8180-8190, 1992.
PIGUET, P. ; GRAU, G. ; VESIN, C. ; LOTSCHER, H. ; GENTZ, R. L. ; LESSLAUER, W. . Evolution of the collage arthristis in mice is arrested by treatment with abti TNF antibody or a recombinant solube TNF receptor.. Journal of Immunology (Baltimore) , v. 77, p. 510-514, 1992.
GENTZ, R. L. ; HAYES, A. ; GRAU, N. ; FOUNTOULAKIS, M. ; LAHM, L. ; OZMEN, L. ; GAROTTA, G. . Analysis of solube human and mouse interferon y receptors expressed in eukaryotic cells.. European Journal of Biochemistry , v. 210, p. 545-554, 1992.
FOUNTOULAKIS, M. ; SCHLAEGER, E. J. ; GENTZ, R. L. ; JURANVILLE, J. ; MANNEBERG, M. ; OZMEN, L. ; GAROTTA, G. . Purification and biochemical characterization of a soluble interferon y receptor produced in insect cells.. European Journal of Biochemistry , v. 198, p. 441-450, 1991.
LOTSCHER, H. ; BROCKHAUS, M. ; DEMBIC, Z. ; GENTZ, R. L. ; GUBLER, U. ; H.P.HOHMANN, ; LAHM, H. ; LOON, A. V. ; PAN, Y. ; SCHLAEGER, E. J. ; STEINMETZ, M. ; TABUCHI, H. ; LESSLAUER, W. . Two distinct tumor necrosis factor receptors - members of a new cytokines receptor gene family.. Biochimica et Biophysica Acta. Molecular Basis of Disease , v. 7, p. 119-142, 1991.
OZMEN, L. ; GENTZ, R. L. ; FOUNTOULAKIS, M. ; BLUTHMANN, H. ; STUBER, D. ; GAROTTA, G. . Preliminary characterization of the soluble IFNy receptor as an immunomodulatory agent.. Journal of Chemotherapy , v. 3, p. 99-102, 1991.
LOTSCHER, H. ; GENTZ, R. L. ; ZULAUF, M. ; LUSTIG, A. ; TABUCHI, H. ; SCHLAEGER, E. J. ; BROCKHAUS, M. ; GALLATI, H. ; MANNEBERG, M. ; LESSLAUER, W. . Recombinant 55 kDa TNF receptor: Stoichiometry of binding to TNFα and TNFβ and inhibition of TNF activity. Journal of Biological Chemistry (Online) , v. 266, p. 18324-18329, 1991.
LESSLAUER, W. ; TABUCHI, H. ; GENTZ, R. L. ; BROCKHAUS, M. ; SCHLAEGER, E. J. ; GRAU, G. ; PIGUET, P. ; POINTAIRE, P. ; VASSALLI, P. ; LOTSCHER, H. . Recombiant solube tumor necrosis factor receptor proteins protec mice from lipopolysaccharide-induced lethality.. European Journal of Immunology , v. 21, p. 2883-2886, 1991.
ABATE, C. ; LUK, D. ; GENTZ, R. L. ; RAUSCHER III, F.J. ; CURRAN, T. . Expression and purification of the leucine zipper and DNA binding domains of Fos and jun: Both Fos and contact DNA directly.. Proceedings of the National Academy of Sciences of the United States of America , v. 87, p. 1032-1036, 1990.
ABATE, C. ; RAUSCHER III, F.J. ; GENTZ, R. L. ; CURRAN, T. . Fos and Jun interact through a structural motif reminiscent of a coiled-coil structure.. Molecular and Cellular Biology , v. 114, p. 01-13, 1990.
DEMBIC, Z. ; LOTSCHER, H. ; GUBLER, U. ; PAN, Y. ; LAHM, H. ; GENTZ, R. L. ; BROCKHAUS, M. ; LESSLAUER, W. . Two human receptores have similar extracellular, but distinct intracellular, domain sequences.. Cytokine (Philadelphia) , v. 2, p. 231-237, 1990.
LOTSCHER, H. ; PAN, Y. ; LAHM, H. ; GENTZ, R. L. ; BROCKHAUS, M. ; TABUCHI, H. ; LESSLAUER, W. . Molecular cloning and expression of the human 55kDa TNF receptor. Cell Research , v. 61, p. 351-360, 1990.
RAUSCHER III, F.J. ; ABATE, C. ; GENTZ, R. L. ; CURRAN, T. . Fos and Jun dimerize via a leucine zipper and bind cooperatively to the AP-1 site.. Revista do Instituto de Ciências da Saúde (UNIP) , v. 132, p. 143-153, 1990.
CASPERS, P. ; GENTZ, R. L. ; MATILE, H. ; PINK, R. ; SINIGAGLIA, F. . The circumsporozoite gene from NF54, a plasmodium falciparum isolate used in malaria vaccine trials.. Molecular and Biochemical Parasitology , v. 35, p. 185-190, 1989.
COHEN, D.R. ; FERREIRA, P.C.P ; GENTZ, R. L. ; CURRAN, T. ; FRANZA, Jr. . The product of a Fos-related gene fra-1 binds cooperatively to the Ap1 site with jun: Transcription factor Ap1 is comprised of multiple protein complexes.. Development, Genes and Evolution , v. 3, p. 173-184, 1989.
COHEN, D.R. ; FERREIRA, P.C.P ; GENTZ, R. L. ; CURRAN, T. ; FRANZA, Jr. . The product of a Fos-related gene fra-1 binds cooperatively to the Ap1 site with jun: Transcription factor Ap1 is comprised of multiple protein complexes.. Development, Genes and Evolution , v. 3, p. 173-184, 1989.
GENTZ, R. L. ; CHEN, C.H. ; ROSEN, C.A. . Biossay for transactivation using purified human immunodeficiency virus tat-encoded protein: transactiviation requires mRNA synthesis.. Proceedings of the National Academy of Sciences of the United States of America , v. 86, p. 821-824, 1989.
GENTZ, R. L. ; RAUSCHER III, F.J. ; ABATE, C. ; CURRAN, T. . Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains.. Science , v. 243, p. 1695-1699, 1989.
DOBELI, H. ; GENTZ, R. L. ; JUCKER, W. ; GAROTTA, G. ; HARTMANN, D. ; HOCHULI, E. . Role of the carboxy-terminal sequence on the biological activity of human immune interferon (IFNy). Journal of Biotechnology , v. 6, p. 199-216, 1988.
GENTZ, R. L. ; CERTA, U. ; TAKACS, B. ; MATILE, H. ; DOBELI, H. ; PINK, R. ; MACKAY, M. ; BONE, N. ; SCAIFE, J. . Major surface atingen p190 of Plasmidium falciparum: Detection of common epitopes present in a variety of plasmodia isolates.. EMBO Journal , v. 7, p. 225-230, 1988.
GENTZ, R. L. ; KUYS, Y. ; ZWIEB, C. ; TAATJES, D. ; BANNWARTH, W. ; STUBER, D. ; IBRAHIMI, I. . Association of degradation and secretion of three chimeric polypeptides in Escherichia coli.. Journal of Bacteriology , v. 170, p. 2212-2220, 1988.
HOCHULI, E. ; BANNWARTH, W. ; DOBELI, H. ; GENTZ, R. L. ; STUBER, D. . Genetic approach to facilitate purification of recombinat proteins with a novel metal chelate adsorbent.. Bio/Technology , v. 11, p. 1321-1325, 1988.
TAKACS, B. ; CERTA, U. ; CRISANTI, A. ; GENTZ, R. L. ; ETLINGER, H. ; JACOT, H. ; MATILE, H. ; PINK, R. ; SINIGAGLIA, F. . Non-polymorphic sequences of the major surface antigen, p190, from P. falciparum merozoites.. Biotechnology Advances , v. 84, p. 57-73, 1988.
CERTA, U. ; MATILDE, H. ; GENTZ, R. L. ; TANABE, K. ; SCAIFE, J. . Genetic polymorphism of Plasmodium falciparum surface antigens.. Revista Brasileira de Otorrinolaringologia , v. 40, p. 178, 1988.
OZMEN, L. ; FOUNTOULAKIS, M. ; LOON, A. V. ; GENTZ, R. L. ; GAROTTA, G. . Importance of the carboxy-terminal end of human IFNy for its binding to the receptor.. Boletim da Campanha Nacional Contra a Tuberculose , v. 7, p. 328, 1988.
BUJARD, H ; GENTZ, R. L. ; LANZER, M. ; STUBER, D. ; MULLER, M. ; IBRAHIMI, I. ; HAUPTLE, M. ; DOBBERSTEIN, B. . A T5 promoter based transcription-translation system for the analysis of proteins in vitro and in vivo.. Methods in Enzymology , v. 155, p. 416-433, 1987.
IBRAHIMI, I. ; GENTZ, R. L. . A functional interaction between th signal peptide and translation apparatus is detected by use of a single point mutation which blocks translocation across mammalian endoplasmic reticulum.. Journal of Biological Chemistry (Online) , v. 262, p. 10289-10194, 1987.
LE GRICE, S. ; GENTZ, R. L. ; BANNWARTH, W. ; KOCHER, H. . Pseudosecretion of Escherichia coli chloramphenicol acetyl transferase by Bacillus subtilis.. Journal of Bacteriology , v. 169, p. 3362-3364, 1987.
GAROTTA, G. ; OZMEN, L. ; DOBELI, H. ; GENTZ, R. L. ; LE GRICE, S. ; BANNWARTH, W. ; HOCHULI, E. ; TALMADGE, K. . Analysis of structure and function of human IFNy.. Journal of Interferon & Cytokine Research , v. 7, p. 685, 1987.
CERTA, U. ; BANNWARTH, W. ; STUBER, D. ; GENTZ, R. L. ; LANZER, M. ; LE GRICE, S. ; S.GUILLOT, ; WENDLER, I. ; HUNSMANN, G. ; BUJARD, H ; MOUS, J. . Subregions of a conserved part of the HIV gp41 transmembrane protein are differentially recognized by antibodies of infected individuals.. EMBO Journal , v. 5, p. 3051-3056, 1986.
DEUSCHLE, U. ; GENTZ, R. L. ; BUJARD, H . Lac repressor blocks transcribing RNA polymerase and terminates transcription. Proceedings of the National Academy of Sciences of the United States of America , v. 83, p. 4134-4137, 1986.
DEUSCHLE, U. ; KAMMERER, W ; GENTZ, R. L. ; BUJARD, H . Promoters of Escherichia coli: A hierarchy of in vivo strength indicates alternate structures.. EMBO Journal , v. 5, p. 2987-2994, 1986.
KAMMERER, W ; DEUSCHLE, U. ; GENTZ, R. L. ; BUJARD, H . Functional dissection of Escherichia coli promoters: Information in the transcribed region is involved in late steps of the overall process.. EMBO Journal , v. 5, p. 2995-3000, 1986.
BUJARD, H ; DEUSCHLE, U. ; KAMMERER, W ; GENTZ, R. L. ; BANNWARTH, W. ; STUBER, D. . Promoters of the E. coli system. In vivo strength and the contribution of elements in the trasnscribed region.. Cell Biology and Toxicology , v. 30, p. 21-29, 1985.
GENTZ, R. L. ; BUJARD, H . Promoters recognized by Escherichia coli polymerase selected by function: Highly efficient promoters from bacteriophage T5. Journal of Bacteriology , v. 10, p. 70-77, 1985.
PESCHKE, U. ; BEUCK, V. ; BUJARD, H ; GENTZ, R. L. ; LE GRICE, S. . Efficient utilization of Escherichia coli transcriptional signals in Bacillus subtilis.. Journal of Molecular Biology , v. 186, p. 547-555, 1985.
BUJARD, H ; BALDARI, C ; BRUNER, M. ; DEUSCHLE, U. ; GENTZ, R. L. ; HUGLES, J. ; KAMMERER, W ; STUBER, D. . Integration of efficient promoters of the E. coli system into plasmid vectors.. Marine Environmental Research , v. 3, p. 65-87, 1983.
GENTZ, R. L. ; LANGNER, A. ; CHANG, A.C.Y ; Cohen, S.N. ; BUJARD, H . Cloning and analysis of strong promoters is made possible by the downstream placemente of a termination signal.. Proceedings of the National Academy of Sciences of the United States of America , v. 78, p. 4936-4940, 1981.

Outras produções

NI, J. ; GENTZ, R. L. ; RUBEN, S. . T1 receptor-like ligand II and uses thereof. 2006.

NI, J. ; GENTZ, R. L. ; SU, J. ; LI, H. . Chemokine alpha-2 antibodies. 2006.

NI, J. ; ROSEN, C.A. ; GENTZ, R. L. ; SU, J. . Human proteins. 2006.

NI, J. ; GENTZ, R. L. . Human endometrial specific steroid-binding factor I, II, and III. 2006.

NI, J. ; LI, H. ; YU, G. ; GENTZ, R. L. . Natural killer cell activating factor II. 2006.

NI, J. ; FENG, P. ; DILLON, P. J. ; GENTZ, R. L. ; MERREGAERT, J. ; SMITS, P. . Epidermal differentiation factor. 2006.

NI, J. ; ROSEN, C.A. ; PAN, G. ; GENTZ, R. L. ; DIXIT, V. . Death domain containing receptor-4 agonist antibodies and methods. 2006.

NI, J. ; ROSEN, C.A. ; DIXIT, V. ; GENTZ, R. L. ; KENNY, J. J. . I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis. 2006.

Y.F.WEI, ; GENTZ, R. L. ; NI, J. ; RUBEN, S. . Tumor necrosis factor receptor-5. 2006.

NI, J. ; GENTZ, R. L. ; ROSEN, C.A. . Galectin 11. 2006.

GENTZ, R. L. ; KREIDER, B. ; ZHANG, J. ; ANTONACCIO, M. ; MENDRICK, D. ; JIMENEZ, P. ; PATEL, V. ; ROSEN, C.A. ; ADAMS, M. D. ; LI, H. ; RUBEN, S. . Antibodies to monocyte-colony inhibitory factor (M-CIF). 2006.

YU, G. ; NI, J. ; DIXIT, V. ; GENTZ, R. L. ; DILLON, P. J. . Death domain containing receptors. 2005.

NI, J. ; YU, G. ; FAN, P. ; GENTZ, R. L. . Human tumor necrosis factor receptor TR9. 2005.

NI, J. ; ROSEN, C.A. ; PAN, G. ; GENTZ, R. L. ; DIXIT, V. . Death domain containing receptor-4 antibodies. 2005.

RUBEN, S. ; ROSEN, C.A. ; LI, Y. ; ZENG, Z. ; K, Hla ; FISCHER, C. L. ; LI, H. ; SOPPET, D. R. ; GENTZ, R. L. ; Y.F.WEI, ; MOORE, P. A. ; YOUNG, P. ; GREENE, J. ; FERRIE, A. M. ; HASTINGS, G. . Antibodies to protein HPMBQ91. 2005.

NI, J. ; YU, G. ; FAN, P. ; GENTZ, R. L. . Antibodies to human tumor necrosis factor receptor TR9. 2005.

GENTZ, R. L. ; HSU, T. ; ROSEN, C.A. ; NI, J. . Tissue factor pathway inhibitor-3. 2005.

RUBEN, S. ; JIMENEZ, P. ; DUAN, D. ; ADAMS, M. D. ; MENDRICK, D. ; ZHANG, J. ; NI, J. ; MOORE, P. A. ; COLEMAN, T. ; GRUBER, J. R. ; DILLON, P. J. ; GENTZ, R. L. . Keratinocyte growth factor-2. 2005.

NI, J. ; ROSEN, C.A. ; PAN, J. G. ; GENTZ, R. L. ; DIXIT, V. . Death domain containing receptor 4. 2005.

NI, J. ; GENTZ, R. L. ; RUBEN, S. ; SHI, E. . Pancreas-derived plasminogen activator inhibitor. 2005.

NI, J. ; RUBEN, S. ; BREWER, L. ; GENTZ, R. L. ; ROSEN, C.A. . Metalloproteinases. 2005.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Death domain containing receptor 5 antibodies. 2005.

GENTZ, R. L. ; CHOPRA, A. ; K. PARVEEN ; SPITZNAGEL, T. ; UNSWORTH, E. ; KHAN, F. . Keratinocyte growth factor-2 formulations. 2005.

NI, J. ; YU, G. ; GENTZ, R. L. . Human endometrial specific steroid-binding factor I, II and III. 2005.

OLSEN, H. ; GENTZ, R. L. ; RUBEN, S. . Synferon. 2005.

RUBEN, S. ; JIMENEZ, P. ; DUAN, D. ; MENDRICK, D. ; ZHANG, J. ; RAMPY, M. A. ; NI, J. ; MOORE, P. A. ; COLEMAN, T. ; GRUBER, J. R. ; DILLON, P. J. ; GENTZ, R. L. . Keratinocyte growth factor-2. 2005.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Death domain containing receptor 5 antibodies. 2005.

GENTZ, R. L. ; KREIDER, B. ; ZHANG, J. ; ANTONACCIO, M. ; MENDRICK, D. ; JIMENEZ, P. ; PATEL, V. ; ROSEN, C.A. ; ADAMS, M. D. ; LI, H. ; RUBEN, S. . Human monocyte colony inhibitory factor (M-CIF) polypeptides. 2004.

YU, G. ; NI, J. ; GENTZ, R. L. ; DILLON, P. J. . Death domain containing receptors. 2004.

NI, J. ; YU, G. ; GENTZ, R. L. . Cytostatin II. 2004.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Death domain containing receptor 5. 2004.

RUBEN, S. ; JIMENEZ, P. ; DUAN, D. ; MENDRICK, D. ; ZHANG, J. ; NI, J. ; MOORE, P. A. ; COLEMAN, T. ; GRUBER, J. R. ; DILLON, P. J. ; GENTZ, R. L. . Keratinocyte growth factor-2. 2004.

NI, J. ; ROSEN, C.A. ; DIXIT, V. ; GENTZ, R. L. ; KENNY, J. J. . I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis. 2004.

NI, J. ; YU, G. ; FAN, P. ; GENTZ, R. L. . Human tumor necrosis factor receptor TR9. 2003.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . T1 receptor-like ligand II polypeptides. 2003.

NI, J. ; ROSEN, C.A. ; GENTZ, R. L. ; J.SU, ; KRISSANSEN, G. ; FAN, P. . Human CCV polypeptides. 2003.

GENTZ, R. L. ; CHOPRA, A. ; K. PARVEEN ; SPITZNAGEL, T. ; UNSWORTH, E. ; KHAN, F. . Keratinocyte growth factor-2 formulations. 2003.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . Pancreas-derived plasminogen activator inhibit. 2003.

LI, Y. ; OELKUCT, M. ; GENTZ, R. L. . Chemokine compositions. 2003.

NI, J. ; ROSEN, C.A. ; DIXIT, V. ; GENTZ, R. L. ; KENNY, J. J. . I-flice, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis. 2003.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Human cystatin E polynucleotides. 2003.

NI, J. ; FAN, P. ; DILLON, P. J. ; GENTZ, R. L. ; MERREGAERT, J. ; SMITS, P. . Human extracellular matrix-1. 2003.

NI, J. ; GENTZ, R. L. ; ROSEN, C.A. ; LIU, F. . Galectin-11 polypeptides. 2003.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . T1 receptor-like ligand II and uses thereof. 2003.

NI, J. ; GENTZ, R. L. ; ROSEN, C.A. . CD33-like protein. 2003.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . Polynucleotides encoding T1 receptor like ligand II. 2003.

LI, H. ; YU, G. ; GENTZ, R. L. ; NI, J. . Human cystatin F antibodies. 2003.

GENTZ, R. L. ; HSU, T. ; ROSEN, C.A. ; NI, J. . Methods of measuring tissue factor pathway inhibitor-3. 2003.

OLSEN, H. ; GENTZ, R. L. ; RUBEN, S. . Synferon. 2003.

YU, G. ; NI, J. ; GENTZ, R. L. ; DILLON, P. J. . Tumor necrosis factor delta polypeptides. 2003.

YU, G. ; NI, J. ; GENTZ, R. L. ; DILLON, P. J. . Polynucleotides encoding human tumor necrosis factor delta. 2003.

YU, G. ; NI, J. ; GENTZ, R. L. ; DILLON, P. J. . Antibodies that bind tumor necrosis factor delta. 2003.

NI, J. ; YU, G. ; GENTZ, R. L. . Mammary transforming protein. 2002.

NI, J. ; GENTZ, R. L. ; J.SU, ; LI, H. . Chemokine alpha 2. 2002.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . Galectin 9 and 10SV polynucleotides. 2002.

NI, J. ; ROSEN, C.A. ; PAN, J. G. ; GENTZ, R. L. . Death domain containing receptor-4 antibodies. 2002.

Y.F.WEI, ; NI, J. ; GENTZ, R. L. ; RUBEN, S. . Tumor necrosis factor receptor 5. 2002.

NI, J. ; LI, H. ; YU, G. ; GENTZ, R. L. . DNA encoding human natural killer cell activating factor II. 2002.

NI, J. ; ROSEN, C.A. ; PAN, J. G. ; GENTZ, R. L. ; DIXIT, V. . Death domain containing receptor-4. 2002.

GENTZ, R. L. ; COLEMAN, T. . Expression control sequences. 2002.

NI, J. ; YU, G. ; GENTZ, R. L. ; DILLON, P. J. . Antibodies that specifically bind Cytostatin III. 2002.

NAUGHTON, R. A. ; ROHRER ; GENTZ, R. L. . Method and system for providing real-time, in situ biomanufacturing process monitoring and control in response to IR spectroscopy. 2002.

NI, J. ; YU, G. ; FAN, P. ; GENTZ, R. L. . Antibodies to human tumor necrosis factor receptor TR9. 2002.

NI, J. ; ROSEN, C.A. ; PAN, J. G. ; GENTZ, R. L. ; DIXIT, V. . Death domain containing receptor 4 nucleic acids and methods. 2002.

NI, J. ; YU, G. ; GENTZ, R. L. . Human endometrial specific steroid-binding factor I, II and III. 2002.

RUBEN, S. ; JIMENEZ, P. ; DUAN, Roxanne ; ADAMS, M. D. ; MENDRICK, D. ; ZHANG, J. ; NI, J. ; MOORE, P. A. ; COLEMAN, T. ; GRUBER, J. R. ; DILLON, P. J. ; GENTZ, R. L. . KERATINOCYTE GROWTH FACTOR-2. 2002.

GENTZ, R. L. ; EBNER, R. ; YU, G. ; RUBEN, S. ; NI, J. ; FAN, P. . TUMOR NECROSIS FACTOR RECEPTORS 6$g(a) AND 6$g(b). 2002.

NI, J. ; YU, G. ; GENTZ, R. L. . Nucleic acid molecules encoding cytostatin II. 2001.

NI, J. ; RUBEN, S. ; BREWER, L. ; GENTZ, R. L. ; ROSEN, C.A. . Metalloproteinases. 2001.

NI, J. ; GENTZ, R. L. ; RUBEN, S. ; SHI, E. . Pancreas-derived plasminogen activator inhibitor. 2001.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Antibodies to human cystatin E. 2001.

NI, J. ; YU, G. ; GENTZ, R. L. ; ROSEN, C.A. . Natural killer cell enhancing factor C. 2001.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Nucleic acid molecules encoding cytostatin I. 2001.

GENTZ, R. L. ; HSU, T. ; ROSEN, C.A. ; NI, J. . Tissue factor pathway inhibitor-3. 2001.

Y.F.WEI, ; GENTZ, R. L. ; NI, J. ; RUBEN, S. . Nucleic acids encoding tumor necrosis factor receptor 5. 2001.

NI, J. ; YU, G. ; GENTZ, R. L. ; ROSEN, C.A. . Polynucleotides encoding natural killer cell enhancing factor C. 2001.

GENTZ, R. L. ; CHOPRA, A. ; K. PARVEEN ; SPITZNAGEL, T. ; UNSWORTH, E. ; KHAN, F. . Keratinocyte growth factor-2 formulations. 2001.

NI, J. ; YU, G. ; GENTZ, R. L. ; DILLON, P. J. . Cytostatin III. 2001.

GENTZ, R. L. ; COLEMAN, T. . Expression control sequences. 2001.

NI, J. ; YU, G. ; GENTZ, R. L. . Human endometrial specific steroid-binding factor I, II and III. 2001.

NAUGHTON, R. A. ; SPITZNAGEL, T. ; GENTZ, R. L. . REAL-TIME, IN SITU BIOMANUFACTURING PROCESS MONITORING AND CONTROL IN RESPONSE TO IR SPECTROSCOPY. 2001.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . T1 RECEPTOR-LIKE LIGAND II AND USES THEREOF. 2001.

MOORE, P. A. ; NI, J. ; SOPPET, D. R. ; COLEMAN, T. ; GENTZ, R. L. ; ENDRESS, Gregory, A. ; LI, Y. ; DILLON, P. J. . HUMAN POLYNUCLEOTIDES, POLYPEPTIDES, AND ANTIBODIES. 2001.

YU, G. ; NI, J. ; GENTZ, R. L. ; DILLON, P. J. . Death domain containing receptors. 2000.

GENTZ, R. L. ; FLEISCHMANN, R. D. . 5-lipoxygenase-activating protein II. 2000.

NI, J. ; YU, G. ; GENTZ, R. L. ; GOCAYNE, J. D. . Human stem cell antigen 2. 2000.

OLSEN, H. ; GENTZ, R. L. ; RUBEN, S. . Synferon, a synthetic interferon. 2000.

LI, H. ; CAO, L. ; NI, J. ; GENTZ, R. L. ; SUTTON, I. ; GRANGER, G. ; ROSEN, C.A. . Polynucleotides encoding human G-protein coupled receptor GPR1. 2000.

RUBEN, S. ; JIMENEZ, P. ; DUAN, D. ; RAMPY, M. A. ; MENDRICK, D. ; ZHANG, J. ; NI, J. ; MOORE, P. A. ; COLEMAN, T. ; GRUBER, J. R. ; DILLON, P. J. ; GENTZ, R. L. . Keratinocyte growth factor-2. 2000.

NI, J. ; YU, G. ; GENTZ, R. L. . Human endometrial specific steroid-binding factor I, II and III. 2000.

LI, H. ; YU, G. ; GENTZ, R. L. ; NI, J. . Human cystatin F. 2000.

NI, J. ; YU, G. ; GENTZ, R. L. . Mammary transforming protein. 2000.

NI, J. ; RUBEN, S. ; BREWER, L. ; GENTZ, R. L. ; ROSEN, C.A. . Metalloproteinases. 2000.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . Galectin 9 and 10SV Polynucleotides. 2000.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Human cystatin E. 2000.

ROSEN, C.A. ; NI, J. ; GENTZ, R. L. . GALECTIN 11. 2000.

GENTZ, R. L. ; NI, J. ; EBNER, R. ; YU, G. ; RUBEN, S. ; FAN, P. . TUMOR NECROSIS FACTOR RECEPTORS 6$g(a) and 6$g(b). 2000.

NI, J. ; ROSEN, C.A. ; GENTZ, R. L. . HUMAN TUMOR NECROSIS FACTOR RECEPTOR-LIKE 2. 2000.

NI, J. ; GENTZ, R. L. ; YU, G. ; FAN, P. . HUMAN TUMOR NECROSIS FACTOR RECEPTOR TR9. 2000.

NI, J. ; ROSEN, C.A. ; GENTZ, R. L. ; LIU, F. . GALECTIN 11. 2000.

YU, G. ; NI, J. ; GENTZ, R. L. ; DILLON, P. J. ; DIXIT, V. . DEATH DOMAIN CONTAINING RECEPTORS. 2000.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . DEATH DOMAIN CONTAINING RECEPTOR 5. 2000.

NI, J. ; ROSEN, C.A. ; PAN, J. G. ; GENTZ, R. L. ; DIXIT, V. . DEATH DOMAIN CONTAINING RECEPTOR 4. 2000.

Y.F.WEI, ; RUBEN, S. ; GENTZ, R. L. ; NI, J. . TUMOR NECROSIS FACTOR RECEPTOR 5. 2000.

GENTZ, R. L. ; CHOPRA, A. ; K. PARVEEN ; SPITZNAGEL, T. ; UNSWORTH, E. ; KHAN, F. . KERATINOCYTE GROWTH FACTOR-2 FORMULATIONS. 2000.

LI, H. ; CAO, L. ; NI, J. ; GENTZ, R. L. ; BULT, C. J. ; RAUSCHER III, F.J. ; SUTTON, I. ; GRANGER, G. ; ROSEN, C.A. . Polynucleotides encoding human G-protein coupled receptor GPRZ. 1999.

NI, J. ; YU, G. ; GENTZ, R. L. ; ROSEN, C.A. . DNA encoding human cystatin E. 1999.

NI, J. ; FAN, P. ; DILLON, P. J. ; GENTZ, R. L. . Epidermal differentiation factor. 1999.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Cytostatin I. 1999.

NI, J. ; GENTZ, R. L. ; ADAMS, M. D. . Ubiquitin conjugating enzymes 8 and 9. 1999.

NI, J. ; GENTZ, R. L. ; YU, G. ; SU, J. ; DILLON, P. J. . DNA encoding the chemotactic cytokine III. 1999.

NI, J. ; GENTZ, R. L. ; ADAMS, M. D. . Ubiquitin conjugating enzymes 7, 8 and 9. 1999.

NI, J. ; YU, G. ; GENTZ, R. L. ; DILLON, P. J. . Cytostatin III nucleic acids encoding. 1999.

NI, J. ; GENTZ, R. L. ; DILLON, P. J. . CD44-like protein and nucleic acids. 1999.

NI, J. ; LI, H. ; YU, G. ; GENTZ, R. L. . Human cystatin F. 1999.

LI, Y. ; OELKUCT, M. ; GENTZ, R. L. . Method of purifying chemokines from inclusion bodies. 1999.

NI, J. ; GENTZ, R. L. ; SU, J. ; LI, H. . Polynucleotides encoding chemokine .alpha.-2. 1999.

NI, J. ; YU, G. ; GENTZ, R. L. ; DILLON, P. J. . Human 4-1BB receptor splicing variant. 1999.

NI, J. ; GENTZ, R. L. ; RUBEN, S. ; SHI, E. . (EN) PANCREAS-DERIVED PLASMINOGEN ACTIVATOR INHIBITOR. 1999.

GENTZ, R. L. ; COLEMAN, T. . EXPRESSION CONTROL SEQUENCES. 1999.

OLSEN, H. ; GENTZ, R. L. ; RUBEN, S. . SYNFERON, A SYNTHETIC TYPE I INTERFERON. 1999.

GENTZ, R. L. ; CHOPRA, A. ; K. PARVEEN ; SPITZNAGEL, T. ; UNSWORTH, E. ; KHAN, F. . KERATINOCYTE GROWTH FACTOR-2 FORMULATIONS. 1999.

LI, H. ; YU, G. ; GENTZ, R. L. ; NI, J. . HUMAN CYSTATIN F. 1999.

NI, J. ; GENTZ, R. L. ; ADAMS, M. D. . Ubiquitin conjugating enzymes 7,8 and 9. 1998.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Cytostatin I. 1998.

BROCKHAUS, M. ; DEMBIC, Z. ; GENTZ, R. L. . DNA encoding a human TNF binding protein. 1998.

LI, Y. ; OELKUCT, M. ; GENTZ, R. L. . (EN) METHOD OF PURIFYING PROTEIN FROM INCLUSION BODIES. 1998.

GENTZ, R. L. ; PATEL, V. ; KREIDER, B. ; ZHANG, J. ; ANTONACCIO, M. ; MENDRICK, D. ; JIMENEZ, P. . (EN) THERAPEUTIC COMPOSITIONS AND METHODS FOR TREATING DISEASE STATES WITH MYELOID PROGENITOR INHIBITORY FACTOR-1 (MPIF-1), MONOCYTE COLONY INHIBITORY FACTOR (M-CIF), AND MACROPHAGE INHIBITORY FACTOR-4 (MIP-4). 1998.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . (EN) GALECTIN 8, 9, 10 AND 10SV. 1998.

NI, J. ; ROSEN, C.A. ; GENTZ, R. L. ; LYN, S. ; Robert, M.H . (EN) HUMAN TUMOR NECROSIS FACTOR RECEPTOR-LIKE 2. 1998.

Y.F.WEI, ; NI, J. ; EBNER, R. ; YU, G. ; RUBEN, S. ; GENTZ, R. L. ; FAN, P. . (EN) TUMOR NECROSIS FACTOR RECEPTOR 5. 1998.

GENTZ, R. L. ; PATEL, V. ; KREIDER, B. ; ZHANG, J. ; ANTONACCIO, M. ; MENDRICK, D. ; JIMENEZ, P. . THERAPEUTIC COMPOSITIONS AND METHODS FOR TREATING DISEASE STATES WITH MYELOID PROGENITOR INHIBITORY FACTOR-1 (MPIF-1), MONOCYTE COLONY INHIBITORY FACTOR (M-CIF), AND MACROPHAGE INHIBITORY FACTOR-4 (MIP-4). 1998.

NI, J. ; GENTZ, R. L. ; ROSEN, C.A. . EN) NUCLEOTIDE SEQUENCE ENCODING THE CD33-LIKE PROTEIN. 1998.

NI, J. ; GENTZ, R. L. ; DILLON, P. J. . EN) CD44-LIKE PROTEIN. 1998.

DUAN, Roxanne ; RUBEN, S. ; JIMENEZ, P. ; RAMPY, M. A. ; MENDRICK, D. ; ZHANG, J. ; NI, J. ; MOORE, P. A. ; COLEMAN, T. ; GENTZ, R. L. . (EN) KERATINOCYTE GROWTH FACTOR-2 (KGF-2 OR FIBROBLAST GROWTH FACTOR-12, KGF-12). 1998.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . (EN) PANCREAS-DERIVED PLASMINOGEN ACTIVATOR INHIBITOR. 1998.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . EN) T1 RECEPTOR-LIKE LIGAND II. 1998.

NI, J. ; GENTZ, R. L. ; ROSEN, C.A. . (EN) T1 RECEPTOR-LIKE LIGAND I. 1998.

GENTZ, R. L. ; NI, J. ; EBNER, R. ; YU, G. ; RUBEN, S. ; FAN, P. . (EN) TUMOR NECROSIS FACTOR RECEPTORS 6$g(a) AND 6$g(b). 1998.

NI, J. ; DILLON, P. J. ; FAN, P. ; GENTZ, R. L. ; MERREGAERT, J. ; SMITS, P. . EN) HUMAN EXTRACELLULAR MATRIX-1. 1998.

NI, J. ; GENTZ, R. L. ; ROSEN, C.A. . EN) POLYNUCLEOTIDES AND POLYPEPTIDES ENCODING RECEPTORS. 1998.

NI, J. ; ROSEN, C.A. ; GENTZ, R. L. ; FAN, P. ; KRISSANSEN, G. ; SU, J. . EN) HUMAN PROTEINS. 1998.

NI, J. ; ROSEN, C.A. ; DIXIT, V. ; GENTZ, R. L. ; KENNY, J. J. . (EN) I-FLICE, A NOVEL INHIBITOR OF TUMOR NECROSIS FACTOR RECEPTOR-1 AND CD-95 INDUCED APOPTOSIS. 1998.

OLSEN, H. ; NI, J. ; Marianne, Murphy ; RUBEN, S. ; GENTZ, R. L. . EN) Fc RECEPTORS AND POLYPEPTIDES. 1998.

NI, J. ; RUBEN, S. ; BREWER, L. ; GENTZ, R. L. ; ROSEN, C.A. . (EN) TACE-LIKE AND MATRILYSIN-LIKE POLYPEPTIDES. 1998.

GENTZ, R. L. ; NI, J. ; ROSEN, C.A. ; DIXIT, V. ; PAN, J. G. . (EN) DEATH DOMAIN CONTAINING RECEPTOR 4 (DR4: DEATH RECEPTOR 4), MEMBER OF THE TNF-RECEPTOR SUPERFAMILY AND BINDING TO TRAIL (AP02-L). 1998.

CHOPRA, A. ; OLSEN, H. ; GENTZ, R. L. ; RUBEN, S. . (EN) MYELIN OLIGODENDROCYTE GLYCOPROTEIN-LIKE PROTEIN (MOGp) AND METHODS OF USE. 1998.

GENTZ, R. L. ; HSU, T. ; NI, J. ; ROSEN, C.A. . EN) TISSUE FACTOR PATHWAY INHIBITOR-3. 1998.

NI, J. ; GENTZ, R. L. ; RUBEN, S. . EN) T1/ST2-RECEPTOR LIGAND III. 1998.

RUBEN, S. ; ROSEN, C.A. ; LI, Y. ; ZENG, Z. ; FISCHER, C. L. ; LI, H. ; SOPPET, D. R. ; GENTZ, R. L. ; Y.F.WEI, ; MOORE, P. A. ; YOUNG, P. ; GREENE, J. ; FERRIE, A. M. . EN) 28 HUMAN SECRETED PROTEINS. 1998.

NI, J. ; GENTZ, R. L. ; YU, G. ; J.SU, ; ROSEN, C.A. . EN) DEATH DOMAIN CONTAINING RECEPTOR 5. 1998.

YU, G. ; GENTZ, R. L. ; NARDELLI, B. ; SHI, E. ; NI, J. . (EN) CYTOSTATIN II. 1998.

NI, J. ; HSU, T. ; YOUNG, P. ; GENTZ, R. L. ; RUBEN, S. . (EN) GDNF RECEPTORS. 1998.

NI, J. ; YU, G. ; FAN, P. ; GENTZ, R. L. . (EN) HUMAN TUMOR NECROSIS FACTOR RECEPTOR TR9. 1998.

GENTZ, R. L. ; FLEISCHMANN, R. D. . 5-lipoxygenase-activating protein II. 1997.

NI, J. ; GENTZ, R. L. ; YU, G. ; ROSEN, C.A. . Polynucleotides encoding cytostatin I. 1997.

NI, J. ; GENTZ, R. L. ; ADAMS, M. D. . Ubiquitin conjugating enzymes 8 and 9. 1997.

BROCKHAUS, M. ; DEMBIC, Z. ; GENTZ, R. L. ; LESSLAUER, W. ; LOTSCHER, H. ; SCHLAEGER, E. J. . Human TNF receptor. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . EN) CYTOSTATIN II. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . (EN) MAMMARY TRANSFORMING PROTEIN. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. ; GOCAYNE, J. D. . EN) HUMAN STEM CELL ANTIGEN 2. 1997.

NI, J. ; FAN, P. ; DILLON, P. J. ; GENTZ, R. L. . EN) OSTEO ANTIVIRAL PROTEIN. 1997.

NI, J. ; YU, G. ; AFONSO, P. ; GENTZ, R. L. ; J.SU, . (EN) HUMAN CHEMOTACTIC CYTOKINE I. 1997.

GOCAYNE, J. D. ; GENTZ, R. L. ; ROSEN, C.A. ; J.SU, . (EN) CYTOSTATIN I. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . (EN) CHEMOTACTIC CYTOKINE III. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . EN) HUMAN 4-1BB RECEPTOR SPLICING VARIANT. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . EN) HUMAN TUMOR NECROSIS FACTOR DELTA AND EPSILON. 1997.

YU, G. ; DIXIT, V. ; GENTZ, R. L. ; DILLON, P. J. . EN) DEATH DOMAIN CONTAINING RECEPTORS. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . EN) CHEMOTACTIC CYTOKINE II. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . EN) HUMAN ENDOMETRIAL SPECIFIC STEROID-BINDING FACTOR I, II AND III. 1997.

NI, J. ; GENTZ, R. L. ; J.SU, ; LI, H. . (EN) CHEMOKINE ALPHA 2. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . EN) CYTOSTATIN III. 1997.

NI, J. ; DILLON, P. J. ; GENTZ, R. L. ; LI, H. . EN) EPIDERMAL DIFFERENTIATION FACTOR. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . EN) HUMAN CYSTATIN F. 1997.

KIRKPATRICK, Robert ; THOTAKURA, Nageswara ; NI, J. ; GENTZ, R. L. ; CHOPRA, A. . EN) CHITOTRIOSIDASE. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. . EN) HUMAN CYSTATIN F. 1997.

NI, J. ; YU, G. ; GENTZ, R. L. ; LI, H. . (EN) HUMAN NATURAL KILLER CELL ACTIVATING FACTOR II. 1997.

NI, J. ; GENTZ, R. L. ; ADAMS, M. D. . (EN) UBIQUITIN CONJUGATING ENZYMES 7, 8 and 9. 1996.

LI, Y. ; NI, J. ; GENTZ, R. L. ; BULT, C. J. ; SUTTON, I. ; ROSEN, C.A. . (EN) HUMAN G-PROTEIN COUPLED RECEPTORS. 1996.

NI, J. ; GENTZ, R. L. ; ROSEN, C.A. . (EN) HUMAN TUMOR NECROSIS FACTOR RECEPTORS. 1996.

NI, J. ; YU, G. ; GENTZ, R. L. ; ROSEN, C.A. . (EN) HUMAN CYSTATIN E. 1996.

NI, J. ; YU, G. ; GENTZ, R. L. ; ROSEN, C.A. . (EN) NATURAL KILLER CELL ENHANCING FACTOR C. 1996.

GENTZ, R. L. ; FLEISCHMANN, R. D. . EN) 5-LIPOXYGENASE-ACTIVATING PROTEIN II. 1995.

DOBELI, H. ; EGGIMANN, B. ; GENTZ, R. L. ; HOCHULI, E. ; STUBER, D. . Affinity peptides. 1994.

CERTA, U. ; GENTZ, R. L. ; TAKACS, B. ; Roche, Hoffmann-La . Plasmodium falciparum merozoite antigen peptides. 1993.

Histórico profissional

Endereço profissional

Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas. , Avenida Antonio Carlos, 6627, 31207-000 - Belo Horizonte, MG - Brasil, Telefone: (031) 34092755, Fax: (031) 0313443648

Experiência profissional

1993 - 1997

Human Genome Sciences, Inc.

Vínculo: Cientista, Enquadramento Funcional: Diretor, Carga horária: 40, Regime: Dedicação exclusiva.

Outras informações:
Como Diretor do Depto. de Expressao e Purificacao de Proteinas da HGS foi responsavel pelo desenvolvimento de processos biologicos e producao de alta escala utilizando varios sistemas de expressao (bacteria, leveduras, baculovirus e mamiferos) incluindo: desenvolvimento de bioreatores, purificacao e remodelagem de proteinas, processos de purificacao por cromatografia e formulacao para candidatos ao IND (Investigational New Grug Application). Responsavel pelo design de uma Planta Piloto GMP para producao de material clinico para as Fases I, II e III.

1984 - 1987

F. Hoffmann-La Roche Ltd.

Vínculo: Cientista, Enquadramento Funcional: Cientista Senior, Carga horária: 40, Regime: Dedicação exclusiva.

Outras informações:
Cientista Senior responsavel pela ''overexpression'' de genes em E.coli (Interferons alfa e gama, PDGF, e antigenos de Malaria e HIV). Desenvolvimento de novos metodos de purificacao para proteinas recombinantes (histidine-tag). Pesquisa exploratoria: Mecanismos de secrecao.

1987 - 1988

Roche Institute Of Molecular Biology

Vínculo: Cientista Visitante, Enquadramento Funcional: Postdoc, Carga horária: 40, Regime: Dedicação exclusiva.

Outras informações:
Postdoc/Visiting Scientist - Roche Institute, Department of Molecular Oncology - Nutley. Projeto: Interacao de oncogenes fos e jun.