David Hughes Walker

Áreas de atuação

Produções bibliográficas

• LABRUNA, M. B. ; MCBRIDE, J. ; WALKER, D. . A preliminary investigation of Ehrlichia species in ticks, humans, dogs, and capybaras from Brazil.. Veterinary Parasitology , v. 143, p. 189-195, 2007.

• zhang, j.g. ; popov, v.l. ; gao, s. ; WALKER, D. ; yu, x.j. . The developmental cycle of Ehrlichia chaffeensis in vertebrate cells. Cellular Microbiology , v. 9, p. 610-618, 2007.

• Cardenas, A.M. ; DOYLE, C.K. ; zhang, j.g. ; WALKER, D. ; MCBRIDE, J. . Glycoproteins gp36 and gp19 has enhanced sensitivity and provides species-specific immunodiagnosis of Ehrlichia canis infection.. Clinical and Vaccine Immunology , v. 14, p. 123-128, 2007.

• Stevenson, H.L. ; Jordan, J.M. ; Peerwani, Z. ; Wang, H.Q. ; WALKER, D. ; Ismail, N. . An intradermal environment promotes a protective type-1 response against systemic monocytotropic ehrlichial infection.. Infection and Immunity , v. 74, p. 4856-4864, 2006.

• de Souza, R. ; Barata, C. ; Santos-Silva, M. ; WALKER, D. ; Bacellar, F. . Rickettsia sibirica isolation from a patient and detection in ticks, Portugal.. Emerging Infectious Diseases , v. 12, p. 1102-1108, 2006.

• MAVROMATIS, k ; DOYLE, C.K. ; Lykidis, A. ; Ivanova, N. ; Francino, M.P. ; Chain, P. ; WALKER, D. ; MCBRIDE, J. . The genome of the obligately intracellular bacterium Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies.. Journal of Bacteriology , v. 188, p. 4015-4023, 2006.

• Cardoso, L.D. ; Freitas, R.N. ; Mafra, C.L. ; LABRUNA, M. B. ; Gennari, S.M. ; WALKER, D. ; Galvao, M.A.M. . 237. Cardoso LD, Freitas RN, Mafra CL, Neves CVB, Figueira FCB, Labruna MB, Gennari SM, WALKER DH, Galvao MAM.. Cadernos de Saúde Pública (FIOCRUZ) , v. 22, p. 495-501, 2006.

• Zavalla-Castro, J.E. ; Zavalla-Velazquez, J.E. ; WALKER, D. ; Olano, J.P. . Fatal human infection with Rickettsia rickettsii in Yucatán, Mexico. Emerging Infectious Diseases , v. 12, p. 672-674, 2006.

• zhang, j.g. ; HAO, J-F ; WALKER, D. ; yu, x.j. . A mutation inactivating the methyltransferase gene in avirulent Madrid E strain Rickettsia prowazekii reverted to wild type in the virulent revertant strain Evir.. Vaccine (Guildford) , v. 24, p. 2317-2323, 2006.

• Zavalla-Velazquez, J.E. ; Laviada-Molina, H ; Zavalla-Castro, J.E. ; Peres-Osorio, C. ; Becerra-Carmona, G. ; Ruiz-Sosa, JA ; Bouyer, D. ; WALKER, D. . Rickettsia felis, the agent of an emerging infectious disease: report of a new case in Mexico. Archives of Medical Research , v. 37, p. 419-422, 2006.

• Ismail, N. ; Stevenson, H.L. ; WALKER, D. . The role of TNF- and IL-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: increased resistance of TNF receptor p55- and p75- deficient mice to fatal ehrlichial infection.. Infection and Immunity , v. 74, p. 1846-1856, 2006.

• Guedes, E. ; Leite, R.C. ; Prata, M.C.A. ; Pacheco, R.C. ; WALKER, D. ; LABRUNA, M. B. . Detection of the tick Rickettsia rickettsii in Amblyomma cajennense in a new Brazilian spotted fever-endemic area in the state of Minas Gerais. Memórias do Instituto Oswaldo Cruz , v. 100, p. 841-845, 2005.

• Ndip, L.M. ; Ndip, R.N. ; Esemu SN ; Dickmu VL ; Fokam EB ; WALKER, D. ; MCBRIDE, J. . Ehrlichial infection in Cameroonian canines by Ehrlichia canis and Ehrlichia ewingii. Veterinary Microbiology (Amsterdam) , v. 111, p. 59-66, 2005.

• DOYLE, C.K. ; LABRUNA, M. B. ; Breitschwerdt EB ; Tang Y ; Corstvet RE ; Hegarty B ; Bloch KC ; Li P ; WALKER, D. ; MCBRIDE, J. . Detection of medically important Ehrlichia by quantitative multicolor Taqman real-time PCR of the dsb gene.. The Journal of Molecular Diagnostics , v. 7, p. 504-510, 2005.

• Zavalla-Castro, J.E. ; Small, M ; Keng, C. ; Bouyer, D. ; Zavalla-Velazquez, J.E. ; WALKER, D. . Transcription of the Rickettsia felis ompA gene in naturally infected fleas. American Journal of Tropical Medicine and Hygiene , v. 73, p. 662-666, 2005.

• Whitworth T ; popov, v.l. ; yu, x.j. ; WALKER, D. ; Bouyer, D. . Expression of Rickettsia prowazekii pld or tlyC gene in Salmonella enterica serovar typhimurium mediates phagosomal escape. Infection and Immunity , v. 73, p. 6668-6673, 2005.

• Valbuena, G. ; WALKER, D. . Changes in the adherens junctions of human endothelial cells infected with spotted fever group rickettsiae.. Virchows Archiv , v. 446, p. 379-382, 2005.

• Mattner J ; DeBord KL ; Ismail N ; Goff RD ; Cantu C ; Zhou D ; Saint-Mezard P ; Wang V ; Gao Y ; Yin N ; Hoebe K ; Schneewind O ; WALKER, D. ; Beutler B . Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature (London) , v. 434, p. 525-529, 2005.

• Stevenson, H.L. ; LABRUNA, M. B. ; Montenieri JA ; Kosoy MY ; Gage KL ; WALKER, D. . Detection of Rickettsia felis in a New World Flea species, Anomiopsyllus nudata (Siphonaptera: Ctenophthalmidae). Journal of Medical Entomology , v. 42, p. 163-167, 2005.

• Lai S ; WALKER, D. ; Elghetany MT . Catastrophic antiphospholipid syndrome: a rare cause of disseminated microvascular thrombotic injury a case report with pathological and molecular correlative studies.. Pathology International , v. 55, p. 144-149, 2005.

• LABRUNA, M. B. ; Camargo LMA ; Camargo EP ; WALKER, D. . Detection of a spotted fever group Rickettsia in the tick Haemaphysalis juxtakochi in Rondonia, Brazil.. Veterinary Parasitology , v. 127, p. 169-174, 2005.

• LABRUNA, M. B. ; Whitworth T ; Bouyer, D. ; MCBRIDE, J. ; Camargo EP ; Camargo LMA ; popov, v.l. ; WALKER, D. . Rickettsia bellii and Rickettsia amblyommii in Amblyomma ticks from the state of Rondônia, Western Amazon, Brazil.. Journal of Medical Entomology , v. 41, p. 1073-1081, 2004.

• Valbuena, G. ; WALKER, D. . Effect of blocking the CXCL9/10-CXCR3 chemokine system in the outcome of endothelial-target rickettsial infections.. American Journal of Tropical Medicine and Hygiene , v. 71, p. 393-399, 2004.

• Calic S ; Galvao, M.A.M. ; Bacellar, F. ; Mafra, C.L. ; Rocha CMBM ; Chamone CB ; Leite, R.C. ; WALKER, D. . Human ehrlichioses in Brazil: first suspect cases.. The Brazilian Journal of Infectious Diseases , v. 8, p. 256-262, 2004.

• Valbuena, G. ; WALKER, D. . Expression of CX3CL1 (fractalkine) in mice with endothelial-target rickettsial infection of the spotted fever group.. Virchows Archiv , v. 446, p. 21-27, 2004.

• Ndip, L.M. ; Fokam EB ; Bouyer, D. ; Ndip, R.N. ; Titanji PK ; WALKER, D. ; MCBRIDE, J. . Detection of Rickettsia africae in patients and ticks along the coastal region of Cameroon. American Journal of Tropical Medicine and Hygiene , v. 71, p. 363-366, 2004.

• McLeod MP ; Qin X ; Karpathy SE ; Gioia J ; Highlander SK ; Fox GE ; McNeill TZ ; Jiang H ; Muzny D ; Yu XJ ; WALKER, D. ; Weinstock GM . Complete genome sequence of Rickettsia typhi and comparison with sequences of other rickettsiae.. Journal of Bacteriology , v. 186, p. 5842-5855, 2004.

• Valbuena, G. ; Jordan JM ; WALKER, D. . T cells mediate cross-protective immunity between spotted group rickettsiae and spotted fever group rickettsiae.. The Journal of Infectious Diseases , v. 190, p. 1221-1227, 2004.

• Olano, J.P. ; Feng HM ; Wen G ; MCBRIDE, J. ; WALKER, D. . Histologic, serologic, and molecular analysis of persistent ehrlichiosis in a murine model. American Journal of Cinical Pathology , v. 195, p. 997-1016, 2004.

• LABRUNA, M. B. ; Gennari, S.M. ; Galvao, M.A.M. ; Mafra, C.L. ; Vidotto O ; Schumaker T ; WALKER, D. . Prevalence of antibodies to spotted fever group rickettsiae in humans and domestic animals in a Brazilian spotted fever-endemic area in the State of São Paulo, Brazil: serologic evidence for infection by Rickettsia rickettsii and another spotted fever group rickettsia.. American Journal of Tropical Medicine and Hygiene , v. 71, p. 93-97, 2004.

• LABRUNA, M. B. ; Bouyer, D. ; MCBRIDE, J. ; Camargo EP ; Camargo LMA ; WALKER, D. . Molecular evidence for a spotted fever group Rickettsia species in the tick Amblyomma longirostre in Brazil. Journal of Medical Entomology , v. 41, p. 533-537, 2004.

• Feng HM ; Whitworth T ; popov, v.l. ; WALKER, D. . Effect of antibody on the rickettsia-host cell interaction. Infection and Immunity , v. 72, p. 3524-3530, 2004.

• Jang W-J ; Kim J-H ; Jung K-D ; Lee S-H ; Choi M-S ; Kim I-S ; WALKER, D. ; Park K-H . First serologic evidence of human spotted fever group rickettsiosis in Korea. Journal of Clinical Microbiology , v. 42, p. 2310-2313, 2004.

• Alcantara VE ; Gallardo EG ; WALKER, D. . Typhus group rickettsiae antibodies in rural Mexico. Emerging Infectious Diseases , v. 10, p. 549-550, 2004.

• Feng HM ; Whitworth T ; Olano, J.P. ; WALKER, D. . Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide protect SCID mice against fatal Rickettsia conorii infection.. Infection and Immunity , v. 72, p. 2222-2228, 2004.

• Ndip, L.M. ; Bouyer, D. ; Travassos da Rosa APA ; Titan J ; Tesh RB ; WALKER, D. . Acute spotted fever rickettsiosis among febrile patients, Cameroon. Emerging Infectious Diseases , v. 10, p. 432-436, 2004.

• Feng HM ; WALKER, D. . Mechanisms of immunity to Ehrlichia muris: a model of human monocytotropic ehrlichiosis. Infection and Immunity , v. 72, p. 996-998, 2004.

• Ismail, N. ; Soong L ; Valbuena, G. ; MCBRIDE, J. ; Olano, J.P. ; WALKER, D. . Overproduction of TNF- by CD8+ type-1 cells and downregulation of IFN- production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichioses.. Journal of Immunology (Baltimore) , v. 172, p. 1786-1800, 2004.

• LABRUNA, M. B. ; Whitworth T ; Horta MC ; Bouyer, D. ; MCBRIDE, J. ; Pinter A ; popov, v.l. ; Gennari, S.M. ; WALKER, D. . Rickettsia species infecting Amblyomma cooperi ticks from an area in the State of Sao Paulo, Brazil, where Brazilian spotted fever is endemic.. Journal of Clinical Microbiology , v. 42, p. 90-98, 2004.