Maria Gabriella Santoro

Possui graduação em Ciências Biológicas - Università di Napoli (1970), doutorado em Virologia - Università di Napoli (1974) e pós-doutorado pela Washington University (1976-1977), pela State University of New York (1982-1987) e pela Cornell University (1987-1988). Atualmente é diretora de laboratório - Consiglio Nazionale delle Ricerche d'Italia, professor titular - Università Di L'aquila e professor titular - II Università degli Studi di Roma Tor Vergata. Tem experiência na área de Bioquímica, com ênfase em Biologia Molecular da Infecção pelo HIV. Seus principais achados foram a identificação do papel das prostaglandinas A e E sobre a proliferação e diferenciação celulares (Nature 263:777, 1976; Blood 105:1750, 2005), descoberta do efeito anti-viral das prostaglandinas ciclopentenônicas (Science 209:1032, 1980; Trends Microbiol 5:276, 1997), identificação das prostaglandinas ciclopentenônicas como bloqueadores da ativação do fator NF-kapaB (PNAS 94:756, 1997; Nature 403:103, 2000; J Virol 68:6890, 1994; JCI 97:1795, 1996; Nature Biotechnol 16:833, 1998, EMBO J 22:2552, 2003).

Informações coletadas do Lattes em 22/11/2022

Acadêmico

Formação acadêmica

Doutorado em Virologia

1974 - 1976

Universita di Napoli
Título: Efeito antiproliferativo de prostaglandinas
Orientador: B M Jaffe

Especialização em Virologia

1972 - 1974

Universita di Napoli

Graduação em Ciências Biológicas

1967 - 1970

Universita di Napoli

Pós-doutorado

1987 - 1988

Pós-Doutorado. , Cornell University.

1986 - 1987

Pós-Doutorado. , State University of New York.

1982 - 1983

Pós-Doutorado. , State University of New York. , Grande área: Ciências Biológicas

1976 - 1977

Pós-Doutorado. , Washington University in Saint Louis.

Áreas de atuação

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular/Especialidade: Biologia Molecular da Infecção Pelo Hiv.

Grande área: Ciências da Saúde / Área: Medicina / Subárea: Clínica Médica/Especialidade: Doenças Infecciosas e Parasitárias.

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular/Especialidade: Proteínas de Estresse Expressão de Proteínas de Choque Térmico Hsp70.

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular/Especialidade: Prostaglandinas Ciclopentenônicas.

Produções bibliográficas

  • AMICI, C ; ROSSI, A ; COSTANZO, A ; CIAFRE, S ; MARINARI, B ; BALSAMO, M ; LEVRERO, M ; SANTORO, M. G. . Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes. The Journal of Biological Chemistry , v. 281, n.11, p. 7110-7117, 2006.

  • PIVA, R ; BELARDO, G ; SANTORO, M. G. . NF-kappaB: a stress-regulated switch for cell survival.. Antioxidants & Redox Signalling , United States, v. 8, n.3-4, p. 478-486, 2006.

  • ROSSIGNOL, J F ; ABU-ZEKRY, M ; HUSSEIN, A ; SANTORO, M. G. . Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebo-controlled trial.. Lancet , UK, v. 368, n.9530, p. 124-129, 2006.

  • CIUCCI, A ; GIANFERRETTI, P ; PIVA, R ; T Guyot ; T J Snape ; ROBERTS, S M ; SANTORO, M. G. . Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer. Cancer Research , v. 66, p. 7678-7685, 2006.

  • ROSSI, Antonio ; CIAFRE, S ; BALSAMO, M ; P Pierimarchi ; SANTORO, M. G. . Induction of Apoptosis in Estrogen Receptor-Negative Breast Cancer Cells by Natural and Synthetic Cyclopentenones: Role of the I{kappa}B Kinase/Nuclear Factor-{kappa}B Pathway. Molecular Pharmacology , v. 70, p. 1812-1821, 2006.

  • AMICI, C ; Di Coro A ; Di Ciucci A ; Chiappa L ; Castilletti C ; Decaro N ; Buobavoglia C ; SANTORO, M. G. . Indomethacin has a potent antiviral activity against SARS coronavirus. Antiviral Therapy (London) , v. 11, p. 1021-1030, 2006.

  • FRAZIA, S La ; AMICI, Carla ; SANTORO, M. G. . Antiviral activity of proteasome inhibitors in herpes simplex virus-1 infection: role of nuclear factor-kappaB. Antiviral Therapy (London) , v. 11, p. 995-1004, 2006.

  • Caselli E ; Fiorentini S ; AMICI, Carla ; Di Luca D ; Caruso A ; SANTORO, M. G. . Human herpesvirus 8 acute infection of endothelial cells induces monocyte chemoattractant protein 1-dependent capillary-like str. Blood (Philadelphia) , v. 109, p. 2718-2726, 2006.

  • PIVA, R ; GIANFERRETTI, P ; CIUCCI, A ; TAULLI, R ; BELARDO, G ; SANTORO, M. G. . 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins. Blood (Philadelphia) , v. 105, n.4, p. 1750-1758, 2005.

  • BERNASCONIO, D ; AMICI, C ; FRAZIA, S La ; IANARO, A ; SANTORO, M. G. . The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells. The Journal of Biological Chemistry , v. 280, n.25, p. 24127-24134, 2005.

  • BICKLEY, J F ; CIUCCI, A ; EVANS, P ; ROBERTS, S M ; ROSS, N ; SANTORO, M. G. . Reactions of some cyclopentenones with selected cysteine derivatives and biological activities of the product thioethers. Bioorganic & Medicinal Chemistry , v. 12, n.12, p. 3221-3227, 2004.

  • AMICI, C ; BELARDO, G ; ROZERA, C ; BERNASCONI, D ; SANTORO, M. G. . Inhibition of herpesvirus-induced HIV-1 replication by cyclopentenone prostaglandins: role of IkappaB kinase (IKK). AIDS (London) , v. 18, n.9, p. 1271-1280, 2004.

  • SANTORO, M. G. ; ROSSI, Antonio ; AMICI, Carla . NF-kappaB and virus infection: who controls whom.. EMBO Journal , Londres, v. 22, n.11, p. 2552-2560, 2003.

  • IANARO, A ; IALENTI, A ; MAFFIA, P ; MEGLIO, P Di ; ROSA, Massimo Di ; SANTORO, M. G. . Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. . Molecular Pharmacology , v. 64, n.1, p. 85-93, 2003.

  • IANARO, A ; MAFFIA, P ; CRUZZOCREA, S ; MAZZON, e ; ROSA, Massimo Di ; IALENTI, A ; SANTORO, M. G. . 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB. FEBS Letters , Londres, v. 553, n.1-2, p. 21-27, 2003.

  • PICCOLI, R ; GUIDA, M ; ACUNZO, G ; STEFANO, M Di ; LAVITOLA, G ; CIRILLO, D ; NAPPI, C ; SANTORO, M. G. . Fertility: hysteroscopic features and endometrial disease. Pathologica (Milano) , v. 95, n.5, p. 233-234, 2003.

  • AMICI, C ; BELARDO, G ; ROSSI, A ; SANTORO, M. G. . Activation of I kappa b kinase by herpes simplex virus type 1. A novel target for anti-herpetic therapy.. The Journal of Biological Chemistry , v. 276, n.31, p. 28759-28766, 2001.

  • ROSSI, A ; KAPAHI, P. ; NATOLI, G. ; TAKAHASHI, T. ; CHEN, Y. ; KARIN, M. ; SANTORO, M. G. . Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase.. Nature (London) , v. 403, n.6765, p. 103-108, 2000.

  • SANTORO, M. G. . Heat shock factors and the control of the stress response.. Biochemical Pharmacology , v. 59, n.1, p. 55-63, 2000.

  • PICA, F. ; PALAMARA, A. T. ; ROSSI, A ; MARCO, A. ; AMICI, C ; SANTORO, M. G. . Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication.. Antimicrobial Agents and Chemotherapy , v. 44, n.1, p. 200-204, 2000.

  • ELIA, G. ; POLLA, B. ; ROSSI, A ; SANTORO, M. G. . Induction of ferritin and heat shock proteins by prostaglandin A1 in human monocytes. Evidence for transcriptional and post-transcriptional regulation.. European Journal of Biochemistry , v. 264, n.3, p. 736-745, 1999.

  • CONTI, C. ; MARCO, A. ; MASTROMARINO, P. ; TOMAO, P. ; SANTORO, M. G. . Antiviral effect of hyperthermic treatment in rhinovirus infection. Antimicrobial Agents and Chemotherapy , v. 43, n.4, p. 822-829, 1999.

  • MARCO, A. ; CARATTOLI, A. ; ROZERA, C ; FORTINI, D. ; GIORGI, C. ; BELARDO, G ; AMICI, C ; SANTORO, M. G. . Induction of the heat-shock response by antiviral prostaglandins in human cells infected with human immunodeficiency virus type 1.. European Journal of Biochemistry , v. 256, n.2, p. 334-341, 1998.

  • MORIMOTO, R. I. ; SANTORO, M. G. . Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection.. Nature Biotechnology , LONDRES, v. 16, n.9, p. 833-888, 1998.

  • SUPERTI, F. ; AMICI, C ; TINARI, A. ; DONELLI, G. ; SANTORO, M. G. . Inhibition of rotavirus replication by prostaglandin A: evidence for a block of virus maturation.. The Journal of Infectious Diseases , v. 178, n.2, p. 564-568, 1998.

  • POLLA, B. S. ; BACHELET, M. ; ELIA, G. ; SANTORO, M. G. . Stress proteins in inflammation.. Ann. N. Y. Academy Scien., v. 851, p. 75-85, 1998.

  • ROSSI, A ; ELIA, G. ; SANTORO, M. G. . Activation of the heat shock factor 1 by serine protease inhibitors. An effect associated with nuclear factor-kappaB inhibition.. The Journal of Biological Chemistry , STANFORD, v. 273, n.26, p. 16446-16452, 1998.

  • SANTORO, M. G. . Antiviral activity of cyclopentenone prostanoids.. Trends in Microbiology , v. 5, n.7, p. 276-281, 1998.

  • ROSSI, A ; ELIA, G. ; SANTORO, M. G. . Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation.. PNAS. Proceedings of the National Academy of Sciences of the United States of America , v. 94, n.2, p. 746-750, 1997.

  • ROSSI, A ; ELIA, G. ; SANTORO, M. G. . 2-Cyclopenten-1-one, a new inducer of heat shock protein 70 with antiviral activity.. The Journal of Biological Chemistry , STANFORD, v. 271, n.50, p. 32192-32196, 1996.

  • ELIA, G. ; MARCO, A. ; ROSSI, A ; SANTORO, M. G. . Inhibition of HSP70 expression by calcium ionophore A23187 in human cells. An effect independent of the acquisition of DNA-binding activity by the heat shock transcription factor.. The Journal of Biological Chemistry , STANFORD, v. 271, n.27, p. 16111-16118, 1996.

  • ROZERA, C ; CARATTOLI, A. ; MARCO, A. ; AMICI, C ; GIORGI, C. ; SANTORO, M. G. . Inhibition of HIV-1 replication by cyclopentenone prostaglandins in acutely infected human cells. Evidence for a transcriptional block.. Journal of Clinical Investigation , v. 97, n.8, p. 1795-1803, 1996.

  • SANTORO, M. G. . Viral infection.. Exs, v. 77, p. 337-357, 1996.

  • PICA, F. ; ROSSI, A ; SANTIROCCO, N. ; PALAMARA, A. ; GARACI, E. ; SANTORO, M. G. . Effect of combined alpha IFN and prostaglandin A1 treatment on vesicular stomatitis virus replication and heat shock protein synthesis in epithelial cells.. Antiviral Research, v. 29, n.2-3, p. 187-198, 1996.

  • CONTI, C. ; MASTROMARINO, P. ; TOMAO, P. ; MARCO, A. ; PICA, F. ; SANTORO, M. G. . Inhibition of poliovirus replication by prostaglandins A and J in human cells.. Antimicrobial Agents and Chemotherapy , v. 40, n.2, p. 367-372, 1996.

  • ELIA, G. ; AMICI, C ; ROSSI, A ; SANTORO, M. G. . Modulation of prostaglandin A1-induced thermotolerance by quercetin in human leukemic cells: role of heat shock protein 70. . Cancer Research , v. 56, n.1, p. 210-217, 1996.

  • AMICI, C ; ROSSI, A ; SANTORO, M. G. . Aspirin enhances thermotolerance in human erythroleukemic cells: an effect associated with the modulation of the heat shock response.. Cancer Research , v. 55, n.19, p. 4452-4457, 1995.

  • ROSSI, A ; SANTORO, M. G. . Induction by prostaglandin A1 of haem oxygenase in myoblastic cells: an effect independent of expression of the 70 kDa heat shock protein.. Biochemical Journal (London) , LONDRES, 1995.

  • SANTORO, M. G. . Heat shock proteins and virus replication: hsp70s as mediators of the antiviral effects of prostaglandins.. Experientia , v. 50, n.11-12, p. 1039-1047, 1994.

  • ROSSI, A ; SANTORO, M. G. . Induction of a 32-kDa stress protein by prostaglandin A1 in cultured murine cells.. Ann. N. Y. Academy Scien., NOVA IORQUE, v. 744, p. 326-329, 1994.

  • ELIA, G. ; SANTORO, M. G. . Effect of quercetin on prostaglandin A1-induced heat shock response in human cells.. Ann. N. Y. Academy Scien., NOVA IORQUE, v. 744, p. 323-325, 1994.

  • AMICI, C ; GIORGI, C. ; ROSSI, A ; SANTORO, M. G. . Selective inhibition of virus protein synthesis by prostaglandin A1: a translational block associated with HSP70 synthesis.. Journal of Virology , v. 68, n.11, p. 6890-6899, 1994.

  • ELIA, G. ; SANTORO, M. G. . Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells.. Biochemical Journal (London) , LONDRES, v. 300, n.Pt 1, p. 201-209, 1994.

  • MARCO, A. ; SANTORO, M. G. . Antiviral effect of short hyperthermic treatment at specific stages of vesicular stomatitis virus replication cycle.. Journal of General Virology , v. 74, n.Pt 8, p. 1685-1690, 1993.

  • AMICI, C ; PALAMARA, A. T. ; SANTORO, M. G. . Induction of thermotolerance by prostaglandin A in human cells.. Experimental Cell Research , v. 207, n.2, p. 230-234, 1993.

  • MASTROMARINO, P. ; CONTI, C. ; PETRUZZIELLO, R. ; MARCO, A. ; PICA, F. ; SANTORO, M. G. . Inhibition of Sindbis virus replication by cyclopentenone prostaglandins: a cell-mediated event associated with heat-shock protein synthesis.. Antiviral Research, v. 20, n.3, p. 209-222, 1993.

  • PICA, F. ; MARCO, A. ; CESARE, F. ; SANTORO, M. G. . Inhibition of vesicular stomatitis virus replication by delta 12-prostaglandin J2 is regulated at two separate levels and is associated with induction of stress protein synthesis.. Antiviral Research, v. 20, n.3, p. 193-208, 1993.

  • AMICI, C ; PALAMARA, A. T. ; GARACI, E. ; SANTORO, M. G. . Inhibition of Sendai virus replication by delta 12-prostaglandin J2: induction of heat shock protein synthesis and alteration of protein glycosylation.. Antiviral Research, v. 19, n.2, p. 129-138, 1992.

  • AMICI, C ; SISTONEN, L. ; SANTORO, M. G. ; MORIMOTO, R. I. . Antiproliferative prostaglandins activate heat shock transcription factor.. PNAS. Proceedings of the National Academy of Sciences of the United States of America , v. 89, n.14, p. 6227-6231, 1992.

  • D'ONOFRIO, C. ; AMICI, C ; PUGLIANIELLO, A. ; FARAONI, I. ; LANZILLI, G. ; SANTORO, M. G. ; BONMASSAR, E. . Comparative anti-viral and anti-proliferative activity of PGA1 and PGJ2 against HTLV-I-infected MT-2 cells.. International Journal Of Cancer, v. 51, n.3, p. 481-488, 1992.

  • AMICI, C ; SANTORO, M. G. . Suppression of virus replication by prostaglandin A is associated with heat shock protein synthesis.. Journal of General Virology , v. 72, n.Pt 8, p. 1877-1885, 1991.

  • SANTORO, M. G. ; GARACI, E. ; AMICI, C . Induction of heat shock protein synthesis by prostaglandins with antineoplastic and antiviral activity.. Advances In Prostaglandin Thromboxane And Leukotriene Research, v. 21, n.B, p. 867-874, 1991.

  • D'ONOFRIO, C. ; AMICI, C ; BONMASSAR, E. ; SANTORO, M. G. . The antiproliferative effect of prostaglandin A and J on HTLV-I transformed cells is associated with induction of a heat-shock protein.. Pharmacological Research , v. 22, n.Suppl 1, p. 41-42, 1990.

  • MARINI, S. ; PALAMARA, A. T. ; GARACI, E. ; SANTORO, M. G. . Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity.. British Journal of Cancer , v. 61, n.3, p. 394-399, 1990.

  • D'ONOFRIO, C. ; ALVINO, E. ; GARACI, E. ; BONMASSAR, E. ; SANTORO, M. G. . Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures.. British Journal of Cancer , v. 61, n.2, p. 207-214, 1990.

  • SANTORO, M. G. ; GARACI, E. ; AMICI, C . Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells.. PNAS. Proceedings of the National Academy of Sciences of the United States of America , v. 86, n.21, p. 8407-8411, 1989.

  • SANTORO, M. G. ; AMICI, C ; ELIA, G. ; BENEDETTO, A. ; GARACI, E. . Inhibition of virus protein glycosylation as the mechanism of the antiviral action of prostaglandin A in Sendai virus-infected cells.. Journal of General Virology , v. 70, n.Pt 4, p. 789-800, 1989.

  • PICCOLI, R ; SANTORO, M. G. ; NAPPI, C ; CAPODANNO, M. ; SANTIS, V. ; TORRE, P. C. L. . Vulvo-vaginal condylomatosis and relapse: combined treatment with electrocauterization and beta-interferon.. Clinical And Experimental Obstetric Gynecology, v. 16, n.1, p. 30-35, 1989.

  • FUKUSHIMA, M. ; KATO, T. ; NARUMIYA, S. ; MIZUSHIMA, Y. ; SASAKI, H. ; TERASHIMA, Y. ; NISHIYAMA, Y. ; SANTORO, M. G. . Prostaglandin A and J: antitumor and antiviral prostaglandins. . Advances In Prostaglandin Thromboxane And Leukotriene Research, v. 19, p. 415-418, 1989.

  • SANTORO, M. G. ; FAVALLI, C. ; MASTINO, E. ; JAFFE, B. M. ; ESTEBAN, M. ; GARACI, E. . Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus.. Archives of Virology , v. 99, n.1-2, p. 89-100, 1988.

  • SANTORO, M. G. ; FUKUSHIMA, M. ; BENEDETTO, A. ; AMICI, C . PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis.. Journal of General Virology , v. 68, n.Pt 4, p. 1153-1158, 1987.

  • SANTORO, M. G. ; AMICI, C . Control of the growth of a human erythroleukemic cell line by prostaglandins.. Advances In Prostaglandin Thromboxane And Leukotriene Research, v. 17, n.B, p. 969-971, 1987.

  • SANTORO, M. G. ; CRISARI, A. ; BENEDETTO, A. ; AMICI, C . Modulation of the growth of a human erythroleukemic cell line (K562) by prostaglandins: antiproliferative action of prostaglandin A.. Cancer Research , v. 46, n.12 Pt 1, p. 6073-6077, 1986.

  • SANTORO, M. G. . Role of prostaglandins in regulation of erythroleukemic cell proliferation and differentiation.. Advances In Prostaglandin Thromboxane And Leukotriene Research, v. 15, p. 395-399, 1985.

  • BENAVENTE, J. ; ESTEBAN, M. ; JAFFE, B. M. ; SANTORO, M. G. . Selective inhibition of viral gene expression as the mechanism of the antiviral action of PGA1 in vaccinia virus-infected cells.. Journal of General Virology , v. 65, n.Pt 3, p. 599-608, 1984.

  • SANTORO, M. G. ; JAFFE, B. M. ; ESTEBAN, M. . Prostaglandin A inhibits the replication of vesicular stomatitis virus: effect on virus glycoprotein.. Journal of General Virology , v. 64, n.Pt 12, p. 2797-2801, 1983.

  • SANTORO, M. G. ; JAFFE, B. M. ; PAEZ, E. ; ESTEBAN, M. . The relationship between the antiviral action of interferon and prostaglandins in virus-infected murine cells.. Biochemical and Biophysical Research Communications , v. 116, n.2, p. 442-448, 1983.

  • BENEDETTO, A. ; CARRUBA, G. ; AMICI, C ; ZANIRATTI, S. ; SANTORO, M. G. . Can SV40 transformation reverse commitment to terminal division in human adult cells in vitro?. Folia Microbiologica (Prague) , v. 6, n.2, p. 107-114, 1983.

  • SANTORO, M. G. ; BENEDETTO, A. ; ZANIRATTI, S. ; GARACI, E. ; JAFFE, B. M. . The relationship between prostaglandins and virus replication: endogenous prostaglandin synthesis during infection and the effect of exogenous PGA on virus production in different cell lines and in persistently infected cells.. Prostaglandins, v. 25, n.3, p. 353-364, 1983.

  • SANTORO, M. G. ; JAFFE, B. M. ; GARACI, E. ; ESTEBAN, M. . Antiviral effect of prostaglandins of the A series: inhibition of vaccinia virus replication in cultured cells.. Journal of General Virology , v. 63, n.2, p. 435-440, 1982.

  • FAVALLI, C. ; LEPORT, P. ; JAFFE, B. M. ; SANTORO, M. G. ; SIMMET, T. ; GOBBO, V. ; GARACI, E. . The differential effects of PGE on the immune response in normal and immunosuppressed mice.. Cellular Immunology , v. 72, n.2, p. 351-359, 1982.

  • SANTORO, M. G. ; JAFFE, B. M. ; ELIA, G. ; BENEDETTO, A. . Prostaglandin A1 induces the synthesis of a new protein in cultured AGMK cells.. Biochemical and Biophysical Research Communications , v. 107, n.4, p. 1179-1184, 1982.

  • HOFER, D. ; DUBITSKY, A. ; MARTI, J. ; SANTORO, M. G. ; REILLY, P. ; JAFFE, B. M. . Prostaglandin E augments the effect of chemotherapy on B-16 melanoma in vivo.. Journal of Surgical Research , v. 32, n.6, p. 555-562, 1982.

  • LEPORT, P. ; FAVALLI, C. ; SANTORO, M. G. ; RINALDI, C. ; JAFFE, B. M. . PGE restores the immune response in chemotherapy-treated, tumor-bearing mice.. Life Sciences , v. 30, n.14, p. 1219-1223, 1982.

  • GARACI, E. ; RINALDI-GARACI, C. ; GOBBO, V. ; FAVALLI, C. ; SANTORO, M. G. ; JAFFE, B. M. . A synthetic analog of prostaglandin E2 is able to induce in vivo theta antigen on spleen cells of adult thymectomized mice.. Cellular Immunology , v. 62, n.1, p. 8-14, 1981.

  • BENEDETTO, A. ; AMICI, C ; DJACZENKO, W. ; ZANIRATTI, S. ; SANTORO, M. G. . Role of fibronectin in the adhesion of Friend erythroleukemia cells.. Experimental Cell Research , v. 134, n.1, p. 219-229, 1981.

  • SANTORO, M. G. ; CARRUBA, G. ; GARACI, E. ; JAFFE, B. M. ; BENEDETTO, A. . Prostaglandins of the A series inhibit Sendai virus replication in cultured cells.. Journal of General Virology , v. 53, n.Pt 1, p. 75-83, 1981.

  • HOFER, D. ; DUBITSKY, A. M. ; REILLY, P. ; SANTORO, M. G. ; JAFFE, B. M. . The interactions between indomethacin and cytotoxic drugs in mice bearing B-16 melanomas.. Prostaglandins, v. 20, n.6, p. 1033-1038, 1980.

  • FAVALLI, C. ; SANTORO, M. G. ; JEZZI, T. ; GOBBO, V. ; RINALDI, C. ; SANTUCCI, L. . Effect of prostaglandins on cellular immune response in mice with melanoma B16. Bolletino Della Societa Italiana Di Biologia Sperimentale, v. 56, n.20, p. 2037-2042, 1980.

  • SANTORO, M. G. ; BENEDETTO, A. ; CARRUBA, G. ; GARACI, E. ; JAFFE, B. M. . Prostaglandin A compounds as antiviral agents.. Science , v. 209, n.4460, p. 1032-1034, 1980.

  • FAVALLI, C. ; GARACI, E. ; ETHEREDGE, E. ; SANTORO, M. G. ; JAFFE, B. M. . Influence of PGE on the immune response in melanoma-bearing mice.. Journal of Immunology (Baltimore) , v. 125, n.2, p. 897-902, 1980.

  • FAVALLI, C. ; GARACI, E. ; SANTORO, M. G. ; SANTUCCI, L. ; JAFFE, B. M. . The effect of PGA1 on the immune response in B-16 melanoma-bearing mice.. Prostaglandins, v. 19, n.4, p. 587-594, 1980.

  • MARESCA, B. ; JAFFE, B. M. ; SANTORO, M. G. . Sulfhydryl groups and the differentiation of murine erythroleukemia cells.. Biochemical and Biophysical Research Communications , v. 91, n.3, p. 1148-1156, 1979.

  • SANTORO, M. G. ; BENEDETTO, A. ; JAFFE, B. M. . Prostaglandin A1 induces differentiation in Friend erythroleukemia cells.. Prostaglandins, v. 17, n.5, p. 719-727, 1979.

  • SANTORO, M. G. ; JAFFE, B. M. . Inhibition of Friend erythroleukaemia-cell tumours in vivo by a synthetic analogue of prostaglandin E2.. British Journal of Cancer , v. 39, n.4, p. 408-413, 1979.

  • SANTORO, M. G. ; BENEDETTO, A. ; JAFFE, B. M. . Effect of endogenous and exogenous prostaglandin E on Friend erythroleukaemia cell growth and differentiation.. British Journal of Cancer , v. 39, n.3, p. 259-267, 1979.

  • SANTORO, M. G. ; BENEDETTO, A. ; JAFFE, B. M. . Hydrocortisone inhibits DMSO - induced differentiation of Friend erythroleukemia cells.. Biochemical and Biophysical Research Communications , v. 85, n.4, p. 1510-1517, 1979.

  • DODI, G. ; SANTORO, M. G. ; JAFFE, B. M. . Effect of a synthetic analogue of PGE2 on exocrine and endocrine pancreatic function in the rat.. Surgery, v. 83, n.2, p. 206-213, 1979.

  • SANTORO, M. G. ; JAFFE, B. M. ; SIMMONS, D. J. . Bone resorption in vitro and in vivo in PGE-treated mice.. Proceedings of the Society For Experimental Biology and Medicine , v. 156, n.2, p. 373-377, 1977.

  • SANTORO, M. G. ; PHILPOTT, G. W. ; JAFFE, B. M. . Dose dependent inhibition of B-16 melanoma growth in vivo by a synthetic analogue of PGE2.. Prostaglandins, v. 14, n.4, p. 645-651, 1977.

  • SANTORO, M. G. ; PHILPOTT, G. W. ; JAFFE, B. M. . Inhibition of B-16 melanoma growth in vivo by a synthetic analog of prostaglandin E2.. Cancer Research , v. 37, n.10, p. 3774-3779, 1977.

  • SANTORO, M. G. ; PHILPOTT, G. W. ; JAFFE, B. M. . Inhibition of tumour growth in vivo and in vitro by prostaglandin E.. Nature (London) , v. 263, n.5580, p. 777-779, 1976.

  • SCHLESINGER, M. J. ; GARACI, E. ; SANTORO, M. G. . Stress Proteins: induction and function.. 1. ed. Heidelberg: Springer-Verlag, 1990. v. 1. 500p .

  • SANTORO, M. G. . Viral infection.. In: U FEIGE; R MORIMOTO; I YAHARA; B POLLA. (Org.). Stress-inducible cellular responses.. 1ed.Basel: Birkhauser-Springer, 1996, v. 1, p. 335-355.

  • SANTORO, M. G. ; GARACI, E. ; AMICI, C . Induction of HSP70 by prostaglandins.. In: M J Schlesinger; E GARACI; M G SANTORO. (Org.). Stress proteins: induction and function.. 1ed.HEIDELBERG: Springer-Verlag, 1990, v. 1, p. 27-44.

Outras produções

SANTORO, M. G. ; ROBERTS, S. M. ; JADHAV, V. ; HAPPE, A. M. ; DAUVERGNE, J. . Cyclopentenones: pharmaceutical useful compounds. 2006.

Histórico profissional

Endereço profissional

  • Consiglio Nazionale delle Ricerche, Istituto Di Medicina Sperimentale, Istituto Di Medicina Sperimentale. , Viale Karl Marx 15, 00137 - Roma, - Itália, Telefone: (396) 86090325, URL da Homepage:

Experiência profissional

1990 - Atual

Università Di L'aquila

Vínculo: Servidor Público, Enquadramento Funcional: Professor titular, Carga horária: 40

Atividades

  • 01/1990

    Pesquisa e desenvolvimento , Facoltà Di Medicina, .,Linhas de pesquisa

  • 01/1990

    Ensino, Microbiologia, Nível: Graduação,Disciplinas ministradas, Microbiologia

1989 - Atual

Consiglio Nazionale delle Ricerche

Vínculo: Servidor Público, Enquadramento Funcional: Diretor de Laboratório, Carga horária: 40

Atividades

  • 01/1989

    Conselhos, Comissões e Consultoria, Istituto Di Medicina Sperimentale, .,Cargo ou função, Diretor de Laboratório.

1988 - Atual

Università degli Studi di Roma "Tor Vergata"

Vínculo: Servidor Público, Enquadramento Funcional: Professor titular, Carga horária: 40

Atividades

  • 01/1988

    Pesquisa e desenvolvimento , Dipartimento Di Medicina Sperimentale, Laboratorio de Virologia.,Linhas de pesquisa

  • 01/1988 - 12/1990

    Ensino, Virologia, Nível: Graduação,Disciplinas ministradas, Virologia