Alejandra Bosco

Pós-doutorado

Idiomas

Áreas de atuação

Produções bibliográficas

• OLIVEIRA-VALENÇA, VIVIANE M. ; BOSCO, ALEJANDRA ; VETTER, MONICA L. ; SILVEIRA, MARIANA S. . On the Generation and Regeneration of Retinal Ganglion Cells. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY , v. 8, p. 581136, 2020.

• ANDERSON, SARAH R. ; ROBERTS, JACQUELINE M. ; ZHANG, JIANMIN ; STEELE, MICHAEL R. ; ROMERO, CESAR O. ; BOSCO, ALEJANDRA ; VETTER, MONICA L. . Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia. Cell Reports , v. 27, p. 2002-2013.e5, 2019.

• BOSCO, ALEJANDRA ; ANDERSON, SARAH R. ; BREEN, KEVIN T. ; ROMERO, CESAR O. ; STEELE, MICHAEL R. ; CHIODO, VINCE A. ; BOYE, SANFORD L. ; HAUSWIRTH, WILLIAM W. ; TOMLINSON, STEPHEN ; VETTER, MONICA L. . Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma. MOLECULAR THERAPY , v. 26, p. 2379-2396, 2018.

• WILLIAMS, PETE A. ; MARSH-ARMSTRONG, NICK ; HOWELL, GARETH R. ; BOSCO, ALEJANDRA ; DANIAS, JOHN ; SIMON, JOHN ; DI POLO, ADRIANA ; KUEHN, MARKUS H. ; PRZEDBORSKI, SERGE ; RAFF, MARTIN ; TROUNCE, IAN . Neuroinflammation in glaucoma: A new opportunity. EXPERIMENTAL EYE RESEARCH , v. 157, p. 20-27, 2017.

• BORDONE, MELINA P. ; GONZÁLEZ FLEITAS, MARÍA F. ; PASQUINI, LAURA A. ; BOSCO, ALEJANDRA ; SANDE, PABLO H. ; ROSENSTEIN, RUTH E. ; DORFMAN, DAMIÁN . Involvement of microglia in early axoglial alterations of the optic nerve induced by experimental glaucoma. JOURNAL OF NEUROCHEMISTRY , v. 142, p. 323-337, 2017.

• BREEN, KEVIN T. ; ANDERSON, SARAH R. ; STEELE, MICHAEL R. ; CALKINS, DAVID J. ; BOSCO, ALEJANDRA ; VETTER, MONICA L. . Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma. Frontiers in Neuroscience , v. 10, p. 526, 2016.

• BOSCO, ALEJANDRA ; BREEN, KEVIN T. ; ANDERSON, SARAH R. ; STEELE, MICHAEL R. ; CALKINS, DAVID J. ; VETTER, MONICA L. . Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma. EXPERIMENTAL EYE RESEARCH , v. 150, p. 34-43, 2016.

• BOSCO, ALEJANDRA ; ROMERO, CESAR O. ; AMBATI, BALAMURALI K. ; VETTER, MONICA L. . In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma. Jove-Journal of Visualized Experiments , v. x, p. e52731, 2015.

• BOSCO, ALEJANDRA ; ROMERO, CESAR O. ; BREEN, KEVIN T. ; CHAGOVETZ, ALEXIS A. ; STEELE, MICHAEL R. ; AMBATI, BALAMURALI K. ; VETTER, MONICA L. . Neurodegeneration severity can be predicted from early microglia alterations monitored in a mouse model of chronic glaucoma. Disease Models & Mechanisms , v. 8, p. 443-455, 2015.

• BOSCO, ALEJANDRA ; CRISH, SAMUEL D. ; STEELE, MICHAEL R. ; ROMERO, CESAR O. ; INMAN, DENISE M. ; HORNER, PHILIP J. ; CALKINS, DAVID J. ; VETTER, MONICA L. . Early Reduction of Microglia Activation by Irradiation in a Model of Chronic Glaucoma. PLoS One , v. 7, p. e43602, 2012.

• BOSCO, ALEJANDRA ; STEELE, MICHAEL R. ; VETTER, MONICA L. . Early microglia activation in a mouse model of chronic glaucoma. JOURNAL OF COMPARATIVE NEUROLOGY , v. 519, p. 599-620, 2011.

• BOSCO, ALEJANDRA ; INMAN, DENISE M. ; STEELE, MICHAEL R. ; WU, GUANGMING ; SOTO, ILEANA ; MARSH-ARMSTRONG, NICHOLAS ; HUBBARD, WALTER C. ; CALKINS, DAVID J. ; HORNER, PHILIP J. ; VETTER, MONICA L. . Reduced Retina Microglial Activation and Improved Optic Nerve Integrity with Minocycline Treatment in the DBA/2J Mouse Model of Glaucoma. Investigative Ophtalmology & Visual Science , v. 49, p. 1437, 2008.

• DUFFY, HEATHER S. ; IACOBAS, IONELA ; HOTCHKISS, KYLIE ; HIRST-JENSEN, BETHANY J. ; BOSCO, ALEJANDRA ; DANDACHI, NADINE ; DERMIETZEL, ROLF ; SORGEN, PAUL L. ; SPRAY, DAVID C. . The Gap Junction Protein Connexin32 Interacts with the Src Homology 3/Hook Domain of Discs Large Homolog 1. JOURNAL OF BIOLOGICAL CHEMISTRY , v. 282, p. 9789-9796, 2007.

• BOSCO, ALEJANDRA ; CUSATO, KAREN ; NICCHIA, GRAZIA P. ; FRIGERI, ANTONIO ; SPRAY, DAVID C. . A Developmental Switch in the Expression of Aquaporin-4 and Kir4.1 from Horizontal to Mu-ller Cells in Mouse Retina. Investigative Ophtalmology & Visual Science , v. 46, p. 3869, 2005.

• CUSATO, KAREN ; BOSCO, ALEJANDRA ; ROZENTAL, RENATO ; GUIMARÃES, CINTHYA A. ; REESE, BENJAMIN E. ; LINDEN, RAFAEL ; SPRAY, DAVID C. . Gap Junctions Mediate Bystander Cell Death in Developing Retina. JOURNAL OF NEUROSCIENCE , v. 23, p. 6413-6422, 2003.

• CUSATO, KAREN ; BOSCO, ALEJANDRA ; LINDEN, RAFAEL ; REESE, BENJAMIN E . Cell death in the inner nuclear layer of the retina is modulated by BDNF. Developmental Brain Research (Cessou em 2005) , v. 139, p. 325-330, 2002.

• BOSCO, A. ; CUSATO, K. ; REESE, B. E. . Differentiation of Postnatal Retinal Cells in Organ Culture. Journal of Neuroscience Methods , 2000.

• BOSCO, A. . Neural Image Segmentation: A Comparative Approach. Journal of Neuroscience Methods , Amsterdam, 2000.

• BOSCO, A. ; LINDEN, R. . BDNF and NT-4 Differentially Modulate Neurite Outgrowth and Pattern in Developing Retinal Ganglion Cells. Journal of Neuroscience Research , New York, v. 57, n.6, p. 759-769, 1999.

• BOSCO, A. ; LINDEN, R. ; CARRI, N. G. . Distribution of Alpha-1 Integrin subunit in Rat Retina. Cell Biology International , v. 18, p. 211-213, 1994.

• BOSCO, A. ; CARRI, N. G. ; LINDEN, R. . Neuritogenesis of Retinal Ganglion Cells is Differentially Promoted by Target Extract Iin Vitro. Brain Research , v. 632, p. 303-307, 1993.

• COSTA, L. F. ; CAMPOS, A. G. ; ESTROZI, L. ; LG, R. ; BOSCO, A. . A Biologically Motivated Approach to Image Representation and its Application to Neuromorphology. In: IEEE International Workshop on Biologically Motivated Computer Vision, 2000, Seul. Abstracts, 2000.

• BOSCO, A. . Neurotrophin-4 Enhances Horizontal Cell Differentiation. In: Society for Neuroscience Annual Meeting, 2000, New Orleans. Abstracts. Washington: Society for Neuroscience, 2000.

• CUSATO, K. ; BOSCO, A. ; REESE, B. E. . Modulation of Cell Death in the Neuroblast Layer and Inner Nuclear Layer Following Early Elimination of the Ganglion Cell Population. In: Society for Neuroscience Annual Meeting, 1999, Miami. Abstracts. Washington: Society for Neuroscience, 1999. v. 25.

• BOSCO, A. . Neurotrophins Regulate Retinal Ganglion Cell Differentiation. In: Neuroscience Research Institute Annual Symposium, UCSB, 1999, Santa Barbara, 1999.

• ARYPIRES, R. ; BOSCO, A. ; LINDEN, R. . Enhancement of BDNF-Induced Neuritogenesis by forskolin is Blocked by Laminin Through Activation of Protein Kinase C. In: Society for Neuroscience Annual Meeting, 1998, Los Angeles. Abstracts. Washington: Society for Neuroscience, 1998.

• BOSCO, A. ; LINDEN, R. . Neurotrophins Differentially Modulate Neurite Outgrowth and Pattern in Developing Retinal Ganglion Cells. In: Society for Neuroscience Annual Meeting, 1997, Miami. Society for Neuroscience Abstracts. Washington: Society for Neuroscience, 1997. v. 24.

• BOSCO, A. ; LINDEN, R. . BDNF and NT-4 Control Retinal Ganglion Cell Differentiation. In: XII Reuniao Anual da Federacao de Sociedades de Biologia Experimental, 1997, Caxambu. Resumos. Riberao Petro: Brazilian Journal of Medical and Biological Research, 1997.

• BOSCO, A. ; CARRI, N. G. ; LINDEN, R. . Neurotrophins Promote Specifically Neuritogenesis of Retinal Ganglion Cells In Vitro. In: International Brain Research Organization World Congress, 1995, Kyoto. Abstracts. Kyoto, 1995. v. A7. p. 144.

• BOSCO, A. ; CARRI, N. G. . Biologia Molecular de la Retina Embrionaria. In: Congreso Latinoamericano de Ciencias Fisiologicas, 1994, Montevideo. Resumenes de la Sociedad Latinoamericana de Ciencias Fisiologicas. Montevideo: ALACF, 1994. v. 1. p. 6.

• BOSCO, A. ; CARRI, N. G. ; LINDEN, R. . Superior Colliculus Extract Differentially Promote Neuritogenesis on Retinal Ganglion Cells In Vitro. In: American Society for Cell Biology Annual Meeting, 1992, San Francisco. Molecular Biology of the Cell. San Francisco: American Society for Cell Biology, 1992.

• BOSCO, A. ; CARRI, N. G. ; LINDEN, R. . Distribution of Alpha- 1 Integrin Subunit in Rat Retina. In: American Association of Anatomists Annual Meeting, 1992, San Diego. Anatomical Records. Charlestone: John Wiley and Sons, 1992. v. 1.

Projetos de pesquisa

• 2021 - Atual

  Generation of induced-retinal ganglion cells by reprogramming late retinal progenitors and adult Müller glia., Descrição: Goal: To optimize in-vivo Klf4 reprogramming strategies for de-novo generation of mouse RGCs.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Alejandra Bosco - Integrante / MARIANA SOUZA DA SILVEIRA - Coordenador.

• 2021 - Atual

  Schlemm?s canal targeted-Tie2 knockdown as a mouse model of adult-onset ocular hypertension and glaucoma, Descrição: Goal: To develop a rodent model of glaucoma that will be relevant to study the pathogenesis of ocular hypertension and neurodegeneration in glaucoma.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Alejandra Bosco - Coordenador / Monica Vetter - Integrante.

• 2020 - 2021

  Pilot Study For Ocular Gene Therapy, Descrição: Goal: To test whether intravitreal AAV vectors alter RGC loss in a new mouse model of glaucoma.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Alejandra Bosco - Coordenador / Monica Vetter - Integrante.

• 2020 - 2021

  Translational Strategies for Neuroprotection in a New Model of Open Angle Glaucoma, Descrição: Goal: To test whether intravitreal AAV vectors alter RGC loss in a new mouse model of glaucoma.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Alejandra Bosco - Coordenador / Monica Vetter - Integrante.

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