Eduardo Osinaga

Possui graduação em Medicina pela Universidad de La Republica(1984) e doutorado em Imunologia do Câncer pela Universite de Technologie de Compiegne(1992). Atualmente é Professor Agregado - Grau 4 da Facultad de Medicina, Investigador de 1o. nível da Pedeciba e Membro do Conselho Científico da Pedeciba.

Informações coletadas do Lattes em 29/06/2015

Acadêmico

Formação acadêmica

Doutorado em Imunologia do Câncer

1987 - 1992

Universite de Technologie de Compiegne
Título: Etude de glycoprotéines associées aux carcinomes a l'aide d'anticorps monoclonaux. Caractérisation moléculaire, structure de l'epitope et interet diagnostique de l'antigène 83D4
Grande área: Ciências da Saúde / Área: Medicina. Setores de atividade: Saúde humana.

Graduação em Medicina

1978 - 1984

Universidad de La Republica

Produções bibliográficas

BABINO, A. ; PRITSCH, O. ; OPPEZZO, A. ; PASQUIER, R. ; OSINAGA, E. ; ALZARI, P. . Molecular cloning of a monoclonal anti-tumor antibody specific for the Tn antigen and expression of an active single-chain Fv fragment.. Hybridoma , v. 16, p. 317-324, 1997.
BEROIS, N. ; VARANGOT, M. ; OSINAGA, E. ; BABINO, A. ; CAIGNAULT, L. ; MUSÉ, I. ; ROSETO, A. . Detection of rare human breast cancer cells. Comparison of an immunomagnetic separation method with immunocytochemistry and RT-PCR.. Anticancer Research , Estados Unidos, v. 17, p. 2639-2646, 1997.
BAY, S. ; LOMAN, R. ; OSINAGA, E. ; NAKADA, H. ; LECRERC, C. ; CANTACUZENE, D. . Preparation of a multiple antigen glycopeptide (MAG) carrying the Tn antigen. A possible approach to a synthetic carbohydrate vaccine.. J Peptide Res, v. 49, p. 620-625, 1997.
OSINAGA, E. ; TELLO, D. ; BATTHYANY, C. ; BIANCHET, M. ; TAVARES, G. ; DURÁN, R. ; CERVEÑANSKY, C. ; CAMOIN, L. ; ROSETO, A. ; ALZARI, P. . Amino acid sequence and three-dimensional structure of the Tn-specific isolectin B4 from Vicia villosa.. Febs Lett , v. 412, p. 190-196, 1997.
OSINAGA, E. ; BABINO, A. ; GROSCLAUDE, J. ; CAIROLI, E. ; BATTHYANY, C. ; BIANCHI, S. ; SIGNORELLI, S. ; VARANGOT, M. ; MUSÉ, I. ; ROSETO, A. . Development of an immuno-lectin-enzymatic assay for the detection of serum carcinoma-associated glycoproteins bearing Tn determinant.. International Journal of Oncology , v. 8, p. 401-406, 1996.
BEUZELINYVRAUT, M. ; BOURGUIGNAT, A. ; PHILLIPS, E. ; ROSETO, A. ; OSINAGA, E. . Immunocytological analysis of the Tn-associated antigen (83D4) in serous effusions from patients with cancer: comparison with Tn soluble glycoprotein.. Journal of Clinical Pathology , USA, v. 48, p. 433-437, 1995.
VARANGOT, M. ; BEROIS, N. ; MUSÉ, I. ; OSINAGA, E. . Nuevos conceptos en la evaluación de las pacientes con carcinoma mamario.. Archivos de Medicina Interna, Uruguai, v. 17, p. 89-97, 1995.
OSINAGA, E. ; PANCINO, G. ; PORCHET, N. ; BEROIS, N. ; De CREMOUX, P. ; MISTRO, D. ; AUBERT, J. P. ; CALVO, F. ; ROSETO, A. . Analysis of an heterogeneous group of breast carcinoma associated glycoproteins bearing Tn determinant.. Breast Cancer Research and Treatment , USA, v. 32, p. 139-152, 1994.
SORENSEN, A. M. ; NIELSEN, C. ; ARENDRUP, M. ; CLAUSEN, H. ; NIELSEN, J. O. ; OSINAGA, E. ; ROSETO, A. ; HANSEN, J. E. S. . Neutralization epitopes on HIV pseudotyped with HTLV-I: Conservation of carbohydrate epitopes.. Journal Of Aids, USA, v. 7, p. 116-123, 1994.
HANSEN, J. E. S. ; SORENSEN, A. ; OLOFSSON, S. ; OSINAGA, E. ; ROSETO, A. . Combination effect on HIV infection in vitro of soluble CD4 and HIV-neutralizing antibodies.. Archives of Virology , USA, v. 134, p. 179-184, 1994.
OSINAGA, E. ; SORENSEN, A. ; TELLO, D. ; ALZARI, P. ; HANSEN, J. E. S. ; ROSETO, A. . Reconnaissance moleculaire de glycopeptides: l'epitope Tn associe aux carcinomes, GalNAc-O-Ser/Thr, est aussi une structure de la gp120 liee a l'infectivite du virus HIV in vitro.. Bulletin Du Cancer, v. 80, p. 535-536, 1993.
EISELE, J-L. ; TELLO, D. ; OSINAGA, E. ; ROSETO, A. ; ALZARI, P. . Crystallization and preliminary crystallographic analysis of a tetrameric isolectin from Vicia villosa, specific for the Tn antigen.. Journal of Molecular Biology , USA, v. 230, p. 670-672, 1993.
CHARPIN, C. ; PANCINO, G. ; OSINAGA, E. ; BONNIER, P. ; LAVAUT, M. N. ; ALLASIA, C. ; ROSETO, A. . Monoclonal antibody 83D4 immunoreactivity in human tissues: cellular distribution, and microcytophotometric analysis of immunoprecipitates on tissue sections.. Anticancer Research , USA, v. 12, p. 209-224, 1992.
OSINAGA, E. ; PANCINO, G. ; PORCHET, N. ; MISTRO, D. ; AUBERT, J. P. ; ROSETO, A. . Analysis of the carcinoma-associated epitope defined by monoclonal antibody 83D4.. Journal Of Tumor Marker Oncology, USA, v. 7, p. 13-24, 1992.
OSINAGA, E. ; PANCINO, G. ; BEUZELIN, M. ; BABINO, A. ; RODRIGUES, D. ; ROBELLO, C. ; TISCORNIA, A. ; PHILLIPS, E. ; BOURGUIGNAT, A. ; ROSETO, A. . Detection of a soluble antigen defined by monoclonal antibody 83D4 in serous effusions associated with breast carcinoma. Cancer , USA, v. 69, p. 1745-1749, 1992.
BAVILLE, F. ; AMMOURI, O. ; CHARPIN, C. ; DELLA-VALLE, V. ; SOULARD, M. ; GUILLEMIN, M. C. ; OSINAGA, E. ; PANCINO, G. ; ROSETO, A. ; BARQUE, J. P. . Production of a mouse monoclonal antibody (B1N) reactive with a human nuclear antigen associated with cell proliferation. . Comptes Rendus de L´Académie des Sciences Serie III - Sciences de La Vie , França, v. 312, p. 301-307, 1991.
CHARPIN, C. ; PANCINO, G. ; BOUBLI, L. ; BLANC, B. ; OSINAGA, E. ; LAVAUT, M. N. ; ALLASIA, C. ; ROSETO, A. . Monoclonal antibody 1BE12 immunoreactivity in human endometrium: correlations with hormone receptors and proliferation cell markers (Ki 67, cathepsin, p.HER-2neu, EGFR, p.myc, p.ras) immunocytochemical assays.. International Journal Of Gynecological Pathology, v. 10, p. 380-393, 1991.
PANCINO, G. ; MORTADA, M. ; CHARPIN, C. ; OSINAGA, E. ; De CREMOUX, P. ; BETAILLE, B. ; GOBERT, M. ; CALVO, F. ; ROSETO, A. . Two monoclonal antibodies identify antigens preferentially expressed on normal human breast versus breast cancer.. Hybridoma , USA, v. 10, n.241, 1991.
PANCINO, G. ; OSINAGA, E. ; CHARPIN, C. ; MISTRO, D. ; BARQUE, J. ; ROSETO, A. . Purification and characterization of a breast-cancer-associated glycoprotein not expressed in normal breast and identified by monoclonal antibody 83D4.. British Journal Of Cancer, Inglaterra, v. 63, p. 390-398, 1991.
PANCINO, G. ; OSINAGA, E. ; CHARPIN, E. ; MISTRO, D. ; BARQUE, J. ; ROSETO, A. . Un anticorps 83D4 identifie un antigene associe au carcinome du sein qui n'est pas detecte dans le sein normal . Bulletin Du Cancer Paris, Paris, v. 77, n.1, p. 99s-103s, 1990.
OSINAGA, E. ; PANCINO, G. ; CHARPIN, C. ; BETAILLE, B. ; Le ROY, M. ; CALVO, F. ; ROSETO, A. . Characterization and distribution in human tissues of a glycoproteic antigen defined by monoclonal antibody 1BE12 raised against the human breast cancer cell line T47D. Cancer Research , USA, v. 50, p. 7333-7342, 1990.
PANCINO, G. ; OSINAGA, E. ; VORAUHER, W. ; KAKOUCHE, A. ; MISTRO, D. ; CHARPIN, C. ; ROSETO, A. . Production of a monoclonal antibody as immunohistochemical marker on paraffin embedded tissues using a new immunization method. Hybridoma , USA, v. 9, p. 389-395, 1990.
PANCINO, G. ; TOUBERT, M. ; OSINAGA, E. ; CHATELET, F. ; Le ROY, M. ; SCHLAGETER, M. ; DESROYS du ROURE, F ; CALVO, F. ; TEILLAC, P. ; NAJEAN, Y. ; ROSETO, A. . Histological and urinary reactivity of monoclonal antibody 1BE12 in bladder carcinoma. Purification of the antigen from urine.. International Journal Of Cancer, USA, v. 47, p. 221-226, 1989.
PANCINO, G. ; DOUSSAL, V. L. ; MORTADA, M. ; BERTHON, P. ; OSINAGA, E. ; CALVO, F. ; ROSETO, A. . Characterization and distribution in normal and tumoral human tissues of breast-cancer associated antigen defined by monoclonal antibody 7B10 . Cancer Research , v. 49, p. 7078-7085, 1989.
OSINAGA, E. ; CAYOTA, A. ; PRITSCH, O. ; RODRIGUES, D. ; SANZ, A. ; ROBELLO, C. . Estadificación preoperatoria del cáncer colo-rectal mediante la asociación de cuatro marcadores tumorales. Acta Bioquímica Clinica Latinoamericana, Uruguai, v. 22, p. 521-521, 1988.
MONTES, J. ; OSINAGA, E. ; GALLO, J. . Gamma-glutamil transpeptidasa en plasma seminal humano. Acta Bioquímica Clinica Latinoamericana, v. 21, p. 313-313, 1987.
SEMPOL, D. ; OSINAGA, E. ; ZIGMAN, S. ; KORC, I. ; SANZ, A. ; RADI, R. ; BERRETTA, J. ; CAYOTA, A. ; SCHWALB, M. . Lactate dehydrogenase activity and its isoenzymes in concentric layers of adult and calf lenses. Current Eye Research, v. 6, p. 4-4, 1987.
OSINAGA, E. ; BARUQUE, S. L. ; CIFUENTES, L. . Niveles séricos de sialoglicoproteínas solubles en ácido perclórico en ratas portadoras de sarcoma de Yoshida. Revista Española de Oncologi, Espanha, v. 32, p. 291-291, 1985.
OSINAGA, E. . Etude comparative entre la phosphatase alcaline et la gamma-glutamyl transpeptidase dans le diagnostic des metastases hepatiques. Journal de Chirurgie, v. 122, p. 17-17, 1985.
BORGES, A. L. ; SOSA, S. ; OSINAGA, E. ; BORGES, P. L. ; PIPPI, R. . Componentes monoclonales en pacientes con carcinomas digestivos. Revista Uruguaya de Patologia Clinica, Uruguai, v. 19, p. 47-47, 1983.
OSINAGA, E. ; BORGES, A. L. ; PUPPI, R. ; CAYOTA, A. ; PACHECO, R. ; HEUGUEROT, C. ; MUT, F. ; LAGO, C. ; MARTINEZ, S. ; TOUYA, E. . Valor de la gamma-glutamiltranspeptidasa en el diagnóstico de las metástasis hepáticas. Su correlación con la centellografía.. Anales de La Facultad de Medicina Uruguay, v. 5, p. 53-53, 1983.
KORC, I. ; MONTES, J. ; OSINAGA, E. ; KORC, B. ; BERRETTA, J. . The state of sulphydryl groups in lenses of insulin-induced hypoglycemic rats. Metabolic Pediatric System Ophfhalmology, v. 7, p. 81-81, 1983.
OSINAGA, E. ; CAMMAY, H. ; MARQUILLO, C. ; BORGES, A. L. ; PUPPI, R. . Valores de actividades enzimaticas en suero de pacientes portadores de neoplasias malignas digestivas. Su relación con la actividad biológica tumoral y el grado clínico de extensión lesional. Anales de La Facultad de Medicina Uruguay, Uruguay, v. 4, p. 147-147, 1981.
OSINAGA, E. . Bases Bioquímicas de la Hemostasis. 1. ed. Montevidéu: Oficina del livro, 1987. v. 300. 220p .
OSINAGA, E. ; CAIROLI, E. ; BATTHYANY, C. ; BIANCHI, S. ; BEUZELIN, M. ; PHILLIPS, E. ; ROSETTO, A. . Comparison of three lectin based methods to detect Tn soluble carcinoma-associated glycoproteins. In: Van Driessche, E; P Rougé; T Beeckmans; T C Bog Hansen. (Org.). Lectins, Biology, Biochemisry and Clinical Biochemistry. Estocolmo: Textop, Hellerup, 1996, v. 11, p. 316-320.
OSINAGA, E. . Bioquímica de la coagulación. In: Israel Korc. (Org.). Bioquímica Fisiológica Humana. 1ed.Montevidéu: Libréria Médica Editorial, 1984, v. 1, p. 85-102.
OSINAGA, E. . Hemoglobina. In: Israel Korc. (Org.). Bioquímica Fisiológica Humana. : , 1984, v. , p. 106-126.
OSINAGA, E. ; MONTES, J. . Regulación metabólica. Generalidades. In: Israel Korc. (Org.). Bioquímica Fisiológica Humana. 1ed.Montevidéu: Libréria Médica Editorial, 1984, v. 1, p. 168-185.

Histórico profissional

Endereço profissional

Facultad de Medicina, Departamento de Bioquímica, Laboratório de Oncologia Básica e Biologia Molecular. , Av. Gral. Flores 2125, UY 3844 - Chui, RS - Brasil, URL da Homepage:

Experiência profissional

1989 - 1993

Pedeciba

Vínculo: Grau 3, Enquadramento Funcional: Investigador de 2o. nível, Carga horária: 0

Outras informações:
Área Biologia

Atividades

Pesquisa e desenvolvimento .,Linhas de pesquisa

1979 - 1979

Facultad de Medicina

Vínculo: Titular, Enquadramento Funcional: Ajudante - Grau 1, Carga horária: 0

Outras informações:
Laboratório de la Clinica Quirúrgica B

Atividades

01/1979
Ensino,,Disciplinas ministradas, Bioquímica