Kevin Tyler

Pós-doutorado

Idiomas

Áreas de atuação

Produções bibliográficas

• DE CARVALHO, TECIA M. U. ; GRISARD, EDMUNDO C. ; FIELD, ROBERT A. ; TYLER, KEVIN M. . Trans-sialidase Stimulates Eat Me Response from Epithelial Cells. Traffic (Copenhagen. Print) , v. 14, p. 853-869, 2013.

• BOUZID, M. ; HUNTER, P. R. ; CHALMERS, R. M. ; Tyler, K. M. . Cryptosporidium Pathogenicity and Virulence. Clinical Microbiology Reviews (Print) , v. 26, p. 115-134, 2013.

• CHI, JEAN F. ; LAWSON, BECKI ; DURRANT, CHRIS ; BECKMANN, KATIE ; JOHN, SHINTO ; ALREFAEI, ABDULWAHED F. ; KIRKBRIDE, KIM ; BELL, DIANA J. ; CUNNINGHAM, ANDREW A. ; TYLER, KEVIN M. . The finch epidemic strain of Trichomonas gallinae is predominant in British non-passerines. Parasitology (London. Print) , v. 140, p. 1234-1245, 2013.

• BOUZID, MAHA ; HUNTER, PAUL R. ; MCDONALD, VINCENT ; ELWIN, KRISTIN ; CHALMERS, RACHEL M. ; TYLER, KEVIN M. . A new heterogeneous family of telomerically encoded proteins. EVOL APPL , v. 6, p. 207-217, 2013.

• JOBE, MOMODOU ; ANWUZIA-IWEGBU, CHARLES ; BANFUL, AMA ; BOSIER, EMMA ; IQBAL, MUBEEN ; JONES, KELLY ; LECUTIER, SUZANNE J ; LEPPER, KASIMIR ; REDMOND, MATT ; ROSS-PARKER, ANDREW ; WARD, EMILY ; WERNHAM, PAUL ; WHIDDEN, ELEANOR M ; TYLER, KEVIN M ; STEVERDING, DIETMAR . Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz (Impresso) , v. 107, p. 946-950, 2012.

• FRANZÉN, OSCAR ; TALAVERA-LÓPEZ, CARLOS ; OCHAYA, STEPHEN ; BUTLER, CLAIRE E ; MESSENGER, LOUISA A ; LEWIS, MICHAEL D ; LLEWELLYN, MARTIN S ; MARINKELLE, CORNELIS J ; TYLER, KEVIN M ; MILES, MICHAEL A ; ANDERSSON, BJÖRN . Comparative genomic analysis of human infective Trypanosoma cruzi lineages with the bat-restricted subspecies T. cruzi marinkellei. BMC Genomics , v. 13, p. 531, 2012.

• BUTLER, CLAIRE E. ; TYLER, KEVIN M. . Membrane traffic and synaptic cross-talk during host cell entry by. Cellular Microbiology (Print) , v. 14, p. 1345-1353, 2012.

• MACHADO, FABIANA, S. . Pathogenesis of Chagas disease: time to move on. Frontiers in Bioscience (Elite Edition) , v. E4, p. 1743, 2012.

• LAWSON, BECKI ; CUNNINGHAM, ANDREW A. ; CHANTREY, JULIAN ; HUGHES, LAURA A. ; JOHN, SHINTO K. ; BUNBURY, NANCY ; BELL, DIANA J. ; TYLER, KEVIN M. . A clonal strain of Trichomonas gallinae is the aetiologic agent of an emerging avian epidemic disease. Infection, Genetics and Evolution (Print) , v. 11, p. 1638-1645, 2011.

• LAWSON, BECKI ; ROBINSON, ROBERT A. ; NEIMANIS, ALEKSIJA ; HANDELAND, KJELL ; ISOMURSU, MARJA ; AGREN, ERIK O. ; HAMNES, INGER S. ; TYLER, KEVIN M. ; CHANTREY, JULIAN ; HUGHES, LAURA A. ; PENNYCOTT, TOM W. ; SIMPSON, VIC R. ; JOHN, SHINTO K. ; PECK, KIRSI M. ; TOMS, MIKE P. ; BENNETT, MALCOLM ; KIRKWOOD, JAMES K. ; CUNNINGHAM, ANDREW A. . Evidence of Spread of the Emerging Infectious Disease, Finch Trichomonosis, by Migrating birds. Ecohealth (New York. Print) , v. 8, p. 143-153, 2011.

• WHEELER, GUY ; TYLER, KEVIN M. . Widefield microscopy for live imaging of lipid domains and membrane dynamics. Biochimica et Biophysica Acta. Biomembranes , v. 1808, p. 634-641, 2011.

• YOSHIDA, NOBUKO ; TYLER, KEVIN M. ; LLEWELLYN, MARTIN S. . Invasion mechanisms among emerging food-borne protozoan parasites. Trends in Parasitology , v. 27, p. 459-466, 2011.

• GRISARD, EDMUNDO C. ; STOCO, PATRÍCIA H. ; WAGNER, GLAUBER ; SINCERO, THAÍS C.M. ; ROTAVA, GIANINNA ; RODRIGUES, JULIANA B. ; SNOEIJER, CRISTIANE Q. ; KOERICH, LEONARDO B. ; SPERANDIO, MAÍSA M. ; BAYER-SANTOS, ETHEL ; FRAGOSO, STENIO P. ; GOLDENBERG, SAMUEL ; TRIANA, OMAR ; VALLEJO, GUSTAVO A. ; TYLER, KEVIN M. ; DÁVILA, ALBERTO M.R. ; STEINDEL, MÁRIO . Transcriptomic analyses of the avirulent protozoan parasite Trypanosoma rangeli. Molecular and Biochemical Parasitology (Print) , v. 174, p. 18-25, 2010.

• ROBINSON, ROBERT A. ; LAWSON, BECKI ; TOMS, MIKE P. ; PECK, KIRSI M. ; KIRKWOOD, JAMES K. ; CHANTREY, JULIAN ; CLATWORTHY, INNES R. ; EVANS, ANDY D. ; HUGHES, LAURA A. ; HUTCHINSON, OLIVER C. ; JOHN, SHINTO K. ; PENNYCOTT, TOM W. ; PERKINS, MATTHEW W. ; ROWLEY, PETER S. ; SIMPSON, VIC R. ; TYLER, KEVIN M. ; CUNNINGHAM, ANDREW A. . Emerging Infectious Disease Leads to Rapid Population Declines of Common British Birds. Plos One , v. 5, p. e12215, 2010.

• BOUZID, MAHA ; TYLER, KEVIN M ; CHRISTEN, RICHARD ; CHALMERS, RACHEL M ; ELWIN, KRISTIN ; HUNTER, PAUL R . Multi-locus analysis of human infective Cryptosporidium species and subtypes using ten novel genetic loci. BMC Microbiology (Online) , v. 10, p. 213, 2010.

• TYLER, KEVIN M. ; WAGNER, GERD K. ; WU, QIONG ; HUBER, KATHARINA T. . Functional Significance May Underlie the Taxonomic Utility of Single Amino Acid Substitutions in Conserved Proteins. Journal of Molecular Evolution , v. 70, p. 395-402, 2010.

• BOUZID, MAHA ; HEAVENS, DARREN ; ELWIN, KRISTIN ; CHALMERS, RACHEL M. ; HADFIELD, STEPHEN J. ; HUNTER, PAUL R. ; TYLER, KEVIN M. . Whole genome amplification (WGA) for archiving and genotyping of clinical isolates of Cryptosporidium species. Parasitology (London. Print) , v. 137, p. 27, 2010.

• Tyler, K. M. ; FRIDBERG, A. ; TORIELLO, K. M. ; OLSON, C. L. ; CIESLAK, J. A. ; HAZLETT, T. L. ; ENGMAN, D. M. . Flagellar membrane localization via association with lipid rafts. Journal of Cell Science , v. 122, p. 859-866, 2009.

• ALMEIDA, CAROLINA R ; STOCO, PATRICIA H ; WAGNER, GLAUBER ; SINCERO, THAÍS CM ; ROTAVA, GIANINNA ; BAYER-SANTOS, ETHEL ; RODRIGUES, JULIANA B ; SPERANDIO, MAÍSA M ; MAIA, ANTÔNIO AM ; OJOPI, ELIDA PB ; ZAHA, ARNALDO ; FERREIRA, HENRIQUE B ; TYLER, KEVIN M ; DÁVILA, ALBERTO MR ; GRISARD, EDMUNDO C ; DIAS-NETO, EMMANUEL . Transcriptome analysis of Taenia solium cysticerci using Open Reading Frame ESTs (ORESTES). Parasites & Vectors , v. 2, p. 35, 2009.

• VILLALTA, FERNANDO ; SCHARFSTEIN, JULIO ; ASHTON, ANTHONY W. ; TYLER, KEVIN M. ; GUAN, FANGXIA ; MUKHERJEE, SHANKAR ; LIMA, MARIA F. ; ALVAREZ, SANDRA ; WEISS, LOUIS M. ; HUANG, HUAN ; MACHADO, FABIANA S. ; TANOWITZ, HERBERT B. . Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitology Research (1987. Print) , v. 104, p. 1251-1260, 2009.

• WANG, XIA ; JOBE, MOMODOU ; TYLER, KEVIN M ; STEVERDING, DIETMAR . Efficacy of common laboratory disinfectants and heat on killing trypanosomatid parasites. Parasites & Vectors , v. 1, p. 35, 2008.

• DE MORAES, MILENE H ; GUARNERI, ALESSANDRA A ; GIRARDI, FABIANA P ; RODRIGUES, JULIANA B ; EGER, IRIANE ; TYLER, KEVIN M ; STEINDEL, MÁRIO ; GRISARD, EDMUNDO C . Different serological cross-reactivity of Trypanosoma rangeli forms in Trypanosoma cruzi-infected patients sera. Parasites & Vectors , v. 1, p. 20, 2008.

• BOUZID, MAHA ; STEVERDING, DIETMAR ; TYLER, KEVIN M . Detection and surveillance of waterborne protozoan parasites. Current Opinion in Biotechnology , v. 19, p. 302-306, 2008.

• FRIDBERG, A. ; OLSON, C. L. ; NAKAYASU, E. S. ; Tyler, K. M. ; ALMEIDA, I. C. ; ENGMAN, D. M. . Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei. Journal of Cell Science , v. 121, p. 522-535, 2008.

• GASPAR DA SILVA, DANIELA ; BARTON, EMMA ; BUNBURY, NANCY ; LUNNESS, PATRICIA ; BELL, DIANA J. ; TYLER, KEVIN M. . Molecular identity and heterogeneity of trichomonad parasites in a closed avian population. Infection, Genetics and Evolution (Print) , v. 7, p. 433-440, 2007.

• BUNBURY, N. ; BARTON, E. ; JONES, C. G. ; GREENWOOD, A. G. ; TYLER, K. M. ; BELL, D. J. . Avian blood parasites in an endangered columbid: Leucocytozoon marchouxi in the Mauritian Pink Pigeon Columba mayeri. Parasitology (London. Print) , v. 134, p. 797, 2007.

• TYLER, KEVIN M . Peer-level multiple source feedback for fitness to practice. Medical Education (Oxford. Print) , v. 40, p. 482-483, 2006.

• TYLER, KEVIN M. ; LUXTON, GEORGE W. G. ; APPLEWHITE, DEREK A. ; MURPHY, SEAN C. ; ENGMAN, DAVID M. . Responsive microtubule dynamics promote cell invasion by Trypanosoma cruzi. Cellular Microbiology (Print) , v. 7, p. 1579-1591, 2005.

• CROXFORD, J. LUDOVIC ; WANG, KEGIANG ; MILLER, STEPHEN D. ; ENGMAN, DAVID M. ; TYLER, KEVIN M. . Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression. Cellular Microbiology (Print) , v. 7, p. 1592-1602, 2005.

• STEVERDING, DIETMAR ; TYLER, KEVIN M . Novel antitrypanosomal agents. Expert Opinion on Investigational Drugs , v. 14, p. 939-955, 2005.

• TYLER, KEVIN M ; GANGULI, AMITAVO ; DÁVILA, ALBERTO M.R . Kinetoplastid Internet Symposium: A KISs for 2002. Trends in Parasitology , v. 18, p. 240, 2002.

• TYLER, KEVIN M . Maintenance of Parasitaemia - is it to die for?. Kinetoplastid Biology and Disease , v. 2, p. 2, 2002.

• DÁVILA, ALBERTO MR ; TYLER, KEVIN M . Combating Kinetoplastid Diseases. Kinetoplastid Biology and Disease , v. 1, p. 6, 2002.

• TYLER, K.M. ; ENGMAN, D.M. . The life cycle of Trypanosoma cruzi revisited. International Journal for Parasitology , v. 31, p. 472-481, 2001.

• TYLER, K . Anisomorphic Cell Division by African Trypanosomes. Protist (Jena. Print) , v. 152, p. 367-378, 2001.

• Tyler, K. M. ; HIGGS, P. G. ; MATTHEWS, K. R. ; GULL, K. . Limitation of Trypanosoma brucei parasitaemia results from density-dependent parasite differentiation and parasite killing by the host immune response. Proceedings - Royal Society. Biological Sciences (Print) , v. 268, p. 2235-2243, 2001.

• DÁVILA, ALBERTO MR ; TYLER, KEVIN M . The net closes on trypanosomatids. Memórias do Instituto Oswaldo Cruz (Impresso) , v. 96, p. 1025-1028, 2001.

• DÁVILA, A.M.R ; GANGULI, A ; TYLER, K.M . Third Internet Conference on Salivarian Trypanosomes and Trypanosomatids. International Journal for Parasitology , v. 31, p. v-vi, 2001.

• TYLER, KEVIN M. ; ENGMAN, DAVID M. . Flagellar elongation induced by glucose limitation is preadaptive forTrypanosoma cruzi differentiation. Cell Motility and the Cytoskeleton (Print) , v. 46, p. 269-278, 2000.

• Tyler, K. M. ; MATTHEWS, K. R. ; GULL, K. . The bloodstream differentiation-division of Trypanosoma brucei studied using mitochondrial markers. Proceedings of the Royal Society B: Biological Sciences , v. 264, p. 1481-1490, 1997.

• SANCHEZ, S. ; TYLER, K. ; ROZENGURT, N. ; LIDA, J. . Comparison of a PCR-based diagnostic assay for Mycoplasma pulmonis with traditional detection techniques. Laboratory Animals (London) , v. 28, p. 249-256, 1994.

Projetos de pesquisa

• 2007 - Atual

  Exploiting the host response to cell invasion by trypanosomes, Descrição: Interaction of Trypanosoma cruzi and host target cell may begin even prior to attachment, with secreted parasite products of the oligopeptidase B and parasite derived eicosanoid thromboxane A2 able to engender calcium mobilization. In addition, host modified substrates of the cysteine protease cruzipain, such as bradykinin, are able to initiate responses from its heterotrimeric G protein coupled receptor (GPCR). The trypanosome surface is an adherent glycocalyx, rich in glycophosphatidyl inositol (GPI)-linked glycoproteins and presumably binding firmly to host cell plasma membranes by cross-linking of glycans and lectins forming a tight synaptic junction the parasite synapse. At the parasite synapse, trypansome mucins, GIPLs (glycosinositol phospholipids), MASPs (mucin-associated surface proteins), DGFs (dispersed gene family), TS (trans-sialidase) and TSL (trans-sialidase-like) proteins display glycans which bind host lectins and oligomerize with host integrins and other GPI-linked glycoproteins of the plasma membrane. Sialic acid present on host glycans (but not synthesized by trypanosomes) can also be bound and transferred within the parasite synapse by the action of the TS, while TS, TSL and DGF proteins in particular appear to be lectins in their own right and are able to bind and further cross-link host glycans on GPI-linked glycoproteins and glycosphingolipids.T. cruzi mucins may also bind laminin via polyvalent galectin-3 oligomers present on the host cell surface or free in the extracellular milieu thus promoting parasite-cell adhesion. A resulting lattice of this type, formed on the outer leaflet of the plasma membrane, may consequently be regarded as a type of lipid raft. This project commenced with the award of a Wellcome grant in 2007 and has continued with signifcant funding from the EU and with some internal funds.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Kevin Tyler - Coordenador / DE CARVALHO, TECIA M. U. - Integrante / FIELD, ROBERT A. - Integrante / OCHAYA, STEPHEN - Integrante / BUTLER, CLAIRE E - Integrante / ANDERSSON, BJÖRN - Integrante / YOSHIDA, NOBUKO - Integrante / WHEELER, GUY - Integrante / WAGNER, GLAUBER - Integrante / STEINDEL, MÁRIO - Integrante / STOCO, PATRICIA H - Integrante / GRISARD, EDMUNDO C - Integrante / TANOWITZ, HERBERT B. - Integrante.

• 2007 - Atual

  Trichomonas gallinae virulence and host susceptibility, Descrição: Avian trichomonosis, caused by the flagellated protozoan Trichomonas gallinae, is a recently emerged infectious disease of British passerines. The aetiological agent, a clonal epidemic strain of the parasite, has caused unprecedented finch mortality and population-level declines in Britain and has since spread to continental Europe. It is now represents a threat to columbids, raptors and passerine species worldwide. Our work focuses on the provision of molecular probes with which to discriminate virulent strains and upon an understanding of the host and parsite interface and the genes which determine whether infection occurs and the extent of pathogenesis.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) / Mestrado acadêmico: (2) / Doutorado: (2) . , Integrantes: Kevin Tyler - Coordenador / CHI, JEAN F. - Integrante / LAWSON, BECKI - Integrante / DURRANT, CHRIS - Integrante / ALREFAEI, ABDULWAHED F. - Integrante / BELL, DIANA J. - Integrante / CUNNINGHAM, ANDREW A. - Integrante / BUNBURY, NANCY - Integrante / BARTON, EMMA - Integrante.

• 2006 - Atual

  Detection and risk assessment of waterborne protozoan parasites, Descrição: The majority of the world s population still live without access to healthy water and the contamination of drinking water with protozoan pathogens poses a serious threat to millions of people in the developing world and the deaths of many hundreds of thousands of children each year. Even in the developed world periodic outbreaks of diarrhoeal diseases are caused by ingesttion of the chlorine resistant cysts protozoan parasites Cryptosporidium sp., Giardia duodenalis. Thus, surveillance of drinking water is imperative to minimize such contaminations and ensure continuous supplies of healthy water world-wide. Work in my laboratory is focussed on the molecular definition of virulence factors of Cryptospodium and Giardia. We use genomics and proteomics to identify these and aim to exploit them once validated for use in the definition of virulent strains, as targets for therapy and prophylaxis, for risk assessment and in the design or refinement of public health intervention or for use in monitoring water supplies. This work is commissioned as part of large multinational programs particularly by the EU commission.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Kevin Tyler - Coordenador / BOUZID, MAHA - Integrante / MCDONALD, VINCENT - Integrante / ELWIN, KRISTIN - Integrante / STEVERDING, DIETMAR - Integrante / CHRISTEN, RICHARD - Integrante / CHALMERS, RACHEL M - Integrante / HEAVENS, DARREN - Integrante / HADFIELD, STEPHEN J. - Integrante.

• 1994 - Atual

  Kinetoplastid Cell Biology, Descrição: Kinetoplastids are evolutionarily divergent flagellates with a variety of single copy organelles that are replicated with fidelity once per cell cycle. They posess an elaborate mitochondrion which is regulated during the complex life-cycle during which extreme changes in morphology and biochemistry are co-ordinately regulated witht he life-cycle. Some kinetoplastids are able to adopt an intracellular life-cycle multiplying within the cells of the vertebrate host. During the past 20 years I and my laboratory have focussed on aspects of kinetoplast cell biology providing insight into how the cells replicate, how they segregate their membranes and how they invade host cells.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (4) / Mestrado acadêmico: (1) / Doutorado: (4) . , Integrantes: Kevin Tyler - Coordenador / BUTLER, CLAIRE E. - Integrante / DE CARVALHO, TECIA M. U. - Integrante / TORIELLO, K. M. - Integrante / OLSON, C. L. - Integrante / CIESLAK, J. A. - Integrante / HAZLETT, T. L. - Integrante / APPLEWHITE, DEREK A. - Integrante / ENGMAN, DAVID M. - Integrante / JOBE, MOMODOU - Integrante / STEVERDING, DIETMAR - Integrante / FRANZÉN, OSCAR - Integrante / MILES, MICHAEL A - Integrante / ANDERSSON, BJÖRN - Integrante / WHEELER, GUY - Integrante / STOCO, PATRÍCIA H. - Integrante / WAGNER, GERD K. - Integrante / WU, QIONG - Integrante / HUBER, KATHARINA T. - Integrante / ALMEIDA, CAROLINA R - Integrante / GRISARD, EDMUNDO C - Integrante / WANG, XIA - Integrante / CROXFORD, J. LUDOVIC - Integrante / WANG, KEGIANG - Integrante / MATTHEWS, K. R. - Integrante / GULL, K. - Integrante / DÁVILA, ALBERTO M.R - Integrante.

Prêmios