Eugenio Uriarte Villares

Idiomas

Áreas de atuação

Produções bibliográficas

• URIARTE, E. . Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors. Journal of Medicinal Chemistry , v. 154, p. 5165-5173, 2011.

• URIARTE, E. . Synthesis, human monoamine oxidase inhibitory activity and molecular docking studies of 3-heteroarylcoumarin derivatives. European Journal of Medicinal Chemistry , v. 46, p. 1147-1152, 2011.

• URIARTE, E. . Using the TOPS-MODE approach to fit multi-target QSAR models for tyrosine kinases inhibitors. European Journal of Medicinal Chemistry , v. 46, p. 2185-2192, 2011.

• URIARTE, E. . Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors. Bioorganic & Medicinal Chemistry Letters (Print) , v. 21, p. 707-709, 2011.

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . New halogenated phenylcoumarins as tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters (Print) , v. 21, p. 3342-3345, 2011.

• MATOS, M. J. ; URIARTE, E. ; SANTANA, L. . MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins. Bioorganic & Medicinal Chemistry Letters (Print) , v. 21, p. 4224-4227, 2011.

• URIARTE, E. . Towards the Discovery of a Novel Class of Monoamine Oxidase Inhibitors: Structure-Property-Activity and Docking Studies on Chromone Amides. Chemmedchem (Print) , v. 6, p. 628-632, 2011.

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Synthesis of 3-arylcoumarins via Suzuki-cross-coupling reactions of 3-chlorocoumarin. Tetrahedron Letters , v. 52, p. 1225-1227, 2011.

• URIARTE, E. ; PEREZ MOLINA E. . Rational design of new agrochemical fungicides using substructural descriptors. Pest Management Science (Print) , v. 67, p. 438-445, 2011.

• URIARTE, E. . Pyridazinopsoralens of wide chemotherapeutic interest. Bioorganic & Medicinal Chemistry (Print) , v. 18, p. 5708-5714, 2010.

• URIARTE, E. . Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B. Bioorganic & Medicinal Chemistry Letters (Print) , v. 20, p. 2709-2712, 2010.

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorganic & Medicinal Chemistry Letters (Print) , v. 20, p. 5157-5160, 2010.

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Regioselective synthesis of bromo-substituted 3-arylcoumarins. Synthesis (Stuttgart) , v. 16, p. 2763-2766, 2010.

• PEREZ MOLINA E. ; URIARTE, E. . Designing novel antitrypanosomal agents from a mixed graph-theoretical substructural approach. Journal of Computational Chemistry , v. 31, p. 882-894, 2010.

• PEREZ MOLINA E. ; URIARTE, E. . Structural contributions of substrates to their binding to P-glycoprotein. A TOPS-MODE approach. Current Pharmaceutical Design (Print) , v. 416, p. 2676-2709, 2010.

• SANTANA, L. ; URIARTE, E. . Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction: O2- vs. N1-Alkylation. Helvetica Chimica Acta , v. 93, p. 309-313, 2010.

• URIARTE, E. . 3D entropy and moments prediction of enzyme classes and experimental-theoretic study of peptide fingerprints in Leishmania parasites. Biochimica et Biophysica Acta. Proteins and Proteomics , v. 1794, p. 1784-1794, 2009.

• URIARTE, E. . Multi-target spectral moment: QSAR for antiviral drugs vs. different viral species. Analytica Chimica Acta (Print) , v. 651, p. 159-164, 2009.

• PEREZ MOLINA E. ; URIARTE, E. . Design of novel antituberculosis compounds using graph-theoretical and substructural approaches. Molecular Diversity , v. 13, p. 445-485, 2009.

• URIARTE, E. . Alignment-free prediction of a Drug-Target Complex Network based on Parameters of Drug Connectivity and Protein Sequence of Receptors. Molecular Pharmaceutics (Print) , v. 6, p. 825-835, 2009.

• URIARTE, E. . Computational chemistry study of 3D-structure-function relationships for enzymes based on Markov models for protein electrostatic, HINT, and van der Waals potentials. Journal of Computational Chemistry , v. 30, p. 1510-1520, 2009.

• URIARTE, E. . Prediction of Enzyme Classes from 3D Structure: 1 a General Model and Examples of Experimental-Theoretic Scoring of Peptide Mass Fingerprints of Leishmania Proteins. Journal of Proteome Research (Print) , v. 8, p. 4372-4382, 2009.

• SANTANA, L. ; URIARTE, E. . Alignment-Free Prediction of Polygalacturonases with Pseudofolding Topological Indices: Experimental Isolation from Coffea arabica and Prediction of a New Sequence. Journal of Proteome Research (Print) , v. 8, p. 2122-2128, 2009.

• SANTANA, L. ; URIARTE, E. . A network-QSAR model for prediction of genetic-component biomarkers in human colorectal cancer. Journal of Theoretical Biology , v. 261, p. 449-458, 2009.

• URIARTE, E. . Multi-target QPDR classification model for human breast and colon cancer-related proteins using star graph topological indices. Journal of Theoretical Biology , v. 257, p. 303-311, 2009.

• URIARTE, E. . Alignment-free prediction of mycobacterial DNA promoters based on pseudo-folding lattice network or star-graph topological indices. Journal of Theoretical Biology , v. 256, p. 458-466, 2009.

• URIARTE, E. . Multi-target spectral moments for QSAR and Complex Networks study of antibacterial drugs. European Journal of Medicinal Chemistry , v. 44, p. 4516-4521, 2009.

• URIARTE, E. . QSAR and complex network study of the chiral HMGR inhibitor structural diversity. Bioorganic & Medicinal Chemistry (Print) , v. 17, p. 165-175, 2009.

• URIARTE, E. . Unified QSAR aproach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Bioorganic & Medicinal Chemistry (Print) , v. 17, p. 569-575, 2009.

• SANTANA, L. ; URIARTE, E. . A New Psoralen Derivatives with Enlarged Antiproliferative Properties. Bioorganic & Medicinal Chemistry Letters (Print) , v. 19, p. 2874-2876, 2009.

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorganic & Medicinal Chemistry Letters (Print) , v. 19, p. 3268-3270, 2009.

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorganic & Medicinal Chemistry Letters (Print) , v. 19, p. 5053-5055, 2009.

• URIARTE, E. . Coumarin as Attractive Casein Kinase 2 (CK2) Inhibitor Scaffold: An Integrate Approach To Elucidate the Putative Binding Motif and Explain Structure-Activity Relationships. Journal of Medicinal Chemistry , v. 51, p. 752-759, 2008.

• SANTANA, L. ; URIARTE, E. . Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of Medicinal Chemistry , v. 51, p. 6740-6751, 2008.

• URIARTE, E. . Quantitative Proteome-Property Relationships (QPPRs). Part 1: Finding biomarkers of organic drugs with mean Markov connectivity indices of spiral networks of blood mass spectra. Bioorganic & Medicinal Chemistry (Print) , v. 16, p. 9684-9693, 2008.

• URIARTE, E. . Using spectral moments of spiral networks based on PSA/mass spectra outcomes to derive quantitative proteome-disease relationships (QPDRs) and predicting prostate cance. Biochemical and Biophysical Research Communications (Print) , v. 372, p. 320-325, 2008.

• URIARTE, E. . Multi-target QSPR Assemble of a Complex Network for the Distribution of Chemicals to Biphasic Systems and Biological Tisúes. Chemometrics and Intelligent Laboratory Systems (Print) , v. 94, p. 160-165, 2008.

• SANTANA, L. ; URIARTE, E. . Proteomics, networks and connectivity indices HP-Lattice Networks. Proteomics (Weinheim. Print) , v. 8, p. 750-778, 2008.

• URIARTE, E. . Stochastic molecular descriptors for polymers. 4. Study of complex mixtures with topological indices of mass spectra spiral and star networks: The blood proteome case. Polymer (Guildford) , v. 49, p. 5575-5587, 2008.

• SANTANA, L. ; URIARTE, E. . QSAR model for Alignment-free Prediction of Human Breast Cancer Biomarkers based on Electrostatic Potentials of Protein pseudo-Folding HP-Lattice Networks. Journal of Computational Chemistry , v. 29, p. 2613-2622, 2008.

• URIARTE, E. . Minireview of Available Skin Sensitization (Q) SARs/Expert Systems. QSAR & Combinatorial Science (Print) , v. 27, p. 60-76, 2008.

• URIARTE, E. . A Comparison of Reactivity Schemes for the Prediction Skin Sensitization Potential. Chemical Research in Toxicology , v. 21, p. 521-541, 2008.

• SANTANA, L. ; URIARTE, E. . Ligands and therapeutic perspectives of adenosine A2A receptors. Current Pharmaceutical Design (Print) , v. 14, p. 1698-1722, 2008.

• PEREZ MOLINA E. ; URIARTE, E. . Quantitative structure-antibacterial activity relationship modeling using a combination of piecewise linear regression-discriminant analysis (I): quantum chemical, topographic, and topological descriptors. International Journal of Quantum Chemistry , v. 108, p. 1856-1871, 2008.

• SANTANA, L. ; URIARTE, E. . Synthesis and complete assignment of the 1H and 13C NMR signals of some oxopyrancoumarin and oxofuropyrancoumarin. Magnetic Resonance in Chemistry , v. 46, p. 701-705, 2008.

• SANTANA, L. ; URIARTE, E. . ANN-QSAR model for selection of anticancer leads from structurally heterogeneous series of compounds. European Journal of Medicinal Chemistry , v. 42, p. 580-585, 2007.

• SANTANA, L. ; URIARTE, E. . Unify QSAR approach to antimicrobials. Part 2: Predicting activity against more than 90 different species in order to halt antibacterial resistance. Bioorganic & Medicinal Chemistry (Print) , v. 15, p. 897-902, 2007.

• SANTANA, L. ; URIARTE, E. . QSAR study of anticoccidial activity for diverse chemical compounds: Prediction and experimental assay of trans-2-(2-nitrovinyl)furan. Bioorganic & Medicinal Chemistry (Print) , v. 15, p. 962-968, 2007.

• SANTANA, L. ; URIARTE, E. . On the applicability of QSAR for recognition of miRNA bioorganic structures at early stages of organism and cell development: Embryo and stem cells. Bioorganic & Medicinal Chemistry (Print) , v. 15, p. 2544-2550, 2007.

• SANTANA, L. ; URIARTE, E. . Divergent Synthesis of Linear and Angular Furocoumarin Acetic Acids from Phloroglucinol. Synlett (Stuttgart) , v. 12, p. 1951-1953, 2007.

• PEREZ MOLINA E. ; SANTANA, L. ; URIARTE, E. . A model for the recognition of protein kinases based on the entropy of van der Waals interactions. Journal of Proteome Research (Print) , v. 6, p. 904-908, 2007.

• PEREZ MOLINA E. ; SANTANA, L. ; URIARTE, E. . 2D-RNA-coupling numbers: a new computational chemistry approach to link secondary structure topology with biological function. Journal of Computational Chemistry , v. 28, p. 1049-1056, 2007.

• URIARTE, E. . Computational chemistry development of a unified free energy Markov model for the distribution of 1300 chemicals to 38 different environmental or biological systems. Journal of Computational Chemistry , v. 28, p. 1909-1923, 2007.

• URIARTE, E. . Computational chemistry comparison of stable/non-stable protein mutants classification models based on 3D and topological indices. Journal of Computational Chemistry , v. 28, p. 1990-1995, 2007.

• SANTANA, L. ; URIARTE, E. . Quantitative Structure Vasodilatory Activity Relationship. Synthesis and In Silico and In Vitro Evaluation of Resveratrol-Coumarin Hybrids. QSAR & Combinatorial Science (Print) , v. 26, p. 317-332, 2007.

• SANTANA, L. ; URIARTE, E. . Chemometrics for QSAR with low sequence homology: Mycobacterial promoter sequences recognition with 2D-RNA entropies. Chemometrics and Intelligent Laboratory Systems (Print) , v. 85, p. 20-26, 2007.

• URIARTE, E. . An evaluation of selected global (Q)SAR/expert systems for the prediction of skin sensitization potential. SAR and QSAR in Environmental Research (Print) , v. 18, p. 515-541, 2007.

• URIARTE, E. . Electrochemical and spectroscopic characterization of amphetamine-like drugs: Application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors. Analytica Chimica Acta (Print) , v. 596, p. 231-241, 2007.

• SANTANA, L. ; URIARTE, E. . Medicinal Chemistry and Bioinformatics current trends in drugs discovery with networks topological indices. Current Topics in Medicinal Chemistry (Print) , v. 7, p. 1015-1029, 2007.

• SANTANA, L. ; URIARTE, E. . A QSAR Model for in silico Screening of MAO-A Inhibitors. Prediction, Synthesis, and Biological Assay of Novel Coumarins. Journal of Medicinal Chemistry , v. 49, p. 1118-1124, 2006.

• SANTANA, L. ; URIARTE, E. . Probabilistic Neural Network Model for the in silico Evaluation of Anti-HIV Activity and Mechanism of Action. Journal of Medicinal Chemistry , v. 49, p. 1149-1156, 2006.

• URIARTE, E. ; SANTANA, L. . New furan Side Tetracyclic Allopsoralen Derivatives: Synthesis and Photobiological Evaluation. Journal of Medicinal Chemistry , v. 49, p. 4317-4326, 2006.

• SANTANA, L. ; URIARTE, E. . Stochastic entropy QSAR for the in silico discovery of anticancer compounds: Prediction, synthesis and in vitro assay of new purine carbanucleosides. Bioorganic & Medicinal Chemistry (Print) , v. 14, p. 1095-1107, 2006.

• SANTANA, L. ; URIARTE, E. . Unify QSAR approach to antimicrobials. Part 1: Predicting antifungal activity against different species. Bioorganic & Medicinal Chemistry (Print) , v. 14, p. 5973-5980, 2006.

• SANTANA, L. ; URIARTE, E. . Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids. Bioorganic & Medicinal Chemistry Letters (Print) , v. 16, p. 257-261, 2006.

• URIARTE, E. . QSAR study for mycobacterial promoters with low sequence homology. Bioorganic & Medicinal Chemistry Letters (Print) , v. 16, p. 547-553, 2006.

• SANTANA, L. ; URIARTE, E. . Regioselective synthesis of O2- and O6-cyclopyrimidine nucleoside analogues. Tetrahedron (Oxford. Print) , v. 62, p. 9949-9952, 2006.

• PEREZ MOLINA E. ; URIARTE, E. . Novel 2D maps and coupling numbers for protein sequences. The first QSAR study of polygalacturonases; isolation and prediction of a novel sequence from Psidium guajava L.. FEBS Letters (Print) , v. 580, p. 723-730, 2006.

• URIARTE, E. ; PEREZ MOLINA E. . An Integrated in Silico Analysis of Drug-Binding to Human Serum Albumin. Journal of Chemical Information and Computer Sciences (Cessou em 2004. Cont. ISSN 1549-9596 Journal of Chemical Information and Modeling) , v. 46, p. 2709-2724, 2006.

• URIARTE, E. . Effect of Protein Backbone Folding on the Stability of Protein-Ligand Complexes. Journal of Proteome Research (Print) , v. 5, p. 105-111, 2006.

• SANTANA, L. ; URIARTE, E. . 3D Comparative Structural Study of 6-hydroxy-4-methyl-5,7-dinitrocoumarin using Experimental and Theoretical Approaches. Structural Chemistry , v. 17, p. 459-464, 2006.

• SANTANA, L. ; URIARTE, E. . Synthesis of 1,2-Disubstituted Carbocyclic Nucleoside Analogues of Cytidine. Helvetica Chimica Acta , v. 89, p. 954-961, 2006.

• SANTANA, L. ; URIARTE, E. . 1,,2-Disubstituted cyclohexane nucleosides: comparative study for the synthesis of cis and trans adenosine. Tetrahedron (Oxford. Print) , v. 61, p. 473-478, 2005.

• SANTANA, L. ; URIARTE, E. . A furan ring expansion approach to the synthesis of novel pyridazino-psoralen derivatives. Tetrahedron (Oxford. Print) , v. 61, p. 4805-4810, 2005.

• PEREZ MOLINA E. ; SANTANA, L. ; URIARTE, E. . Unified Markov thermodynamics based on stochastic forms to classify drug considering molecular structure, partition system and biological species: distribution of the antimicrobial G1 on rat tissues. Bioorganic & Medicinal Chemistry Letters (Print) , v. 15, p. 551-557, 2005.

• SANTANA, L. ; URIARTE, E. . QSAR for anti RNA-virus activity, synthesis, and assay of anti-RSV carbonucleosides given an unify representation of spectral moments, quadratic, and topological indices. Bioorganic & Medicinal Chemistry Letters (Print) , v. 15, p. 2932-2937, 2005.

• URIARTE, E. . Proteins QSAR with Markov average electrostatic potentials. Bioorganic & Medicinal Chemistry Letters (Print) , v. 15, p. 5088-5094, 2005.

• SANTANA, L. ; URIARTE, E. . Predicting stabilityof Arc repressor mutants with protein stochastic moments. Bioorganic & Medicinal Chemistry (Print) , v. 13, p. 323-331, 2005.

• SANTANA, L. ; URIARTE, E. . Design, Synthesis and Photobiological Properties of 3,4-Cyclopentenepsoralens. Bioorganic & Medicinal Chemistry (Print) , v. 13, p. 809-817, 2005.

• PEREZ MOLINA E. ; URIARTE, E. . Predicting multiple drugs side effects with a general drug-target interaction thermodynamic Markov model. Bioorganic & Medicinal Chemistry (Print) , v. 13, p. 1119-1129, 2005.

• URIARTE, E. . 3DQSAR Harkov model for drug induced eosinophilia-theoretical prediction and preliminary experimental assay of the antimicrobial drug G1. Bioorganic & Medicinal Chemistry (Print) , v. 13, p. 1523-1530, 2005.

• URIARTE, E. . Proteins Markovian 3D-QSAR with spherically-truncated average electrostatic potentials. Bioorganic & Medicinal Chemistry (Print) , v. 13, p. 3641-3647, 2005.

• PEREZ MOLINA E. ; URIARTE, E. . Stochastic-Based Descriptors Studying Biopolimers Biophysical Properties: Extended MARCH-INSIDE Methodologies Describing Antibacterial Activity of Lactoferricin Derivatives. Biopolymers (New York. Print) , v. 77, p. 247-256, 2005.

• URIARTE, E. . Biopolymer stochastic moments. 1. Modeling human rhinoviruses cellular recognition with protein surface electrostatic moments. Biopolymers (New York. Print) , v. 77, p. 296-303, 2005.

• PEREZ MOLINA E. ; SANTANA, L. ; URIARTE, E. . Markovian chemicals in silico design (MARCH-INSIDE), a promising approach for computer aided molecular design III: 2.5D indices for the discovery of antibacterials. Journal of Molecular Modeling (Online) , v. 11, p. 116-123, 2005.

• PEREZ MOLINA E. ; URIARTE, E. . Recognition of stable protein mutants with 3D stochastic average electrostatic potentials. FEBS Letters (Print) , v. 579, p. 4297-4301, 2005.

• URIARTE, E. ; SANTANA, L. . In Silico Studies toward the Discovery of New Anti-HIV Nucleoside Compounds through the Use of TOPS-MODE and 2D/3D Connectivity Indices. 2. Purine Derivatives. Journal of Chemical Information and Computer Sciences (Cessou em 2004. Cont. ISSN 1549-9596 Journal of Chemical Information and Modeling) , v. 45, p. 502-514, 2005.

• SANTANA, L. ; URIARTE, E. . Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity. Current Medicinal Chemistry , v. 12, p. 887-916, 2005.

• PEREZ MOLINA E. ; URIARTE, E. . Stochastic molecular descriptors for polymers. 2. Spherical truncation of electrostatic interactions on entropy based polymers 3D-QSAR. Polymer (Guildford) , v. 46, p. 2791-2798, 2005.

• URIARTE, E. . Stochastic molecular descriptors for polymers. 3. Markov electrostatic moments as polymer 2D-folding descriptors: RNA-QSAR for mycobacterial promoters. Polymer (Guildford) , v. 46, p. 6461-6473, 2005.

• PEREZ MOLINA E. ; URIARTE, E. . 2D RNA-QSAR: assigning ACC oxidase family membership with stochastic molecular descriptors; isolation and prediction of a sequence from Psidium guajava L.. Bioorganic & Medicinal Chemistry Letters (Print) , v. 15, p. 2932-2937, 2005.

• URIARTE, E. . Effect of counterion on thermodynamic micellar properties of tetradecylpyridinium in aqueous solutions. Colloid and Polymer Science (Print) , v. 283, p. 456-460, 2005.

• URIARTE, E. . Folding degrees of azurins and pseudoazurins. Ref. 0 revista: Computational Biology and. Computational Biology and Chemistry (Print) , v. 29, p. 345-353, 2005.

• URIARTE, E. . A short and Conveniente Synthesis of New 1,2-Disubstituted Carbocyclic Nucleoside Analogues of Pyrimidine Based on a Cyclopentene Ring. Synthesis (Stuttgart) , v. 4, p. 543-548, 2004.

• URIARTE, E. ; SANTANA, L. . Synthesis of 1-[2-(hydroxymethyl)cyclohexyl]pyrimidine analogues of nucleosides: A comparative study. Synthesis (Stuttgart) , v. 15, p. 2517-2522, 2004.

• PEREZ MOLINA E. ; URIARTE, E. . Markov entropy backbone electrostatic descriptors for predicting proteins biological activity. Bioorganic & Medicinal Chemistry Letters (Print) , v. 14, p. 4691-4695, 2004.

• PEREZ MOLINA E. ; URIARTE, E. . Stochastic-based descriptors studying peptides biological properties: modeling the bitter tasting threshold of dipeptides. Bioorganic & Medicinal Chemistry (Print) , v. 12, p. 4815-4822, 2004.

• PEREZ MOLINA E. ; URIARTE, E. . Designing Antibacterial Compounds through a Topological Substructural Approach. Journal of Chemical Information and Computer Sciences (Cessou em 2004. Cont. ISSN 1549-9596 Journal of Chemical Information and Modeling) , v. 44, p. 515-521, 2004.

• URIARTE, E. ; SANTANA, L. . Synthesis and Characterizazion of New Pyridazinofurocoumarin derivatives Under Multiple Tandem Mass Spectrometry Conditions Using Ion Trap Mass Spectrometer. RCM. Rapid Communications in Mass Spectrometry , v. 18, p. 564-570, 2004.

• URIARTE, E. . Effects of cis-resveratrol on inflamatory murime macrophages: antioxidant activity and down-regulation of inflammatory genes. Journal of Leukocyte Biology , v. 75, p. 1156-1165, 2004.

• URIARTE, E. ; SANTANA, L. . Furocoumarins in Medicinal Chemistry. Síntesis, Natural Occurrence and Biological Activity. Current Medicinal Chemistry , v. 11, p. 3239-3261, 2004.

• PEREZ MOLINA E. ; URIARTE, E. . Stochastic molecular descriptors for polymers. 1. Modelling the properties of icosahedral viruses with 3D-Markovian negentropies. Polymer (Guildford) , v. 45, p. 3845-3853, 2004.

• PEREZ MOLINA E. ; URIARTE, E. . Markovian backbone negentropies: Molecular descriptors for protein research. I. Predicting protein stability in arc repressor mutants. Proteins (Print) , v. 56, p. 715-723, 2004.

• URIARTE, E. ; SANTANA, L. . Methyl derivatives of tetracyclic psoralen analogues: antiproliferative activity and interaction with DNA. ARKIVOC , v. 5, p. 131-146, 2004.

• URIARTE, E. . Novel Pyrone Side Tetracyclic Psoralen Derivatives: Synthesis and Photobiological Activity. Journal of Medicinal Chemistry , v. 46, p. 3800-3810, 2003.

• URIARTE, E. ; SANTANA, L. . New Arylpiperazine Derivatives with High Affinity for 1A, D2A and 5-HT2A Receptors. Bioorganic & Medicinal Chemistry Letters (Print) , v. 13, p. 175-178, 2003.

• URIARTE, E. ; SANTANA, L. . Regioselective Preparation of Dihydrofuro[3,2-g]coumarin-6-one. Synthesis (Stuttgart) , v. 1, p. 27-29, 2003.

• URIARTE, E. . Efficient Preparation of 2-Substituted Pyridazino[4,3-h]psoralen Derivatives. Synlett (Stuttgart) , v. 14, p. 2225-2227, 2003.

• URIARTE, E. ; SANTANA, L. . Synthesis and convenient functionalisation of pyridazinofurocoumarins: nitrogenated isosters of potent DNA inhibitors. Tetrahedron (Oxford. Print) , v. 59, p. 8171-8176, 2003.

• URIARTE, E. ; SANTANA, L. ; PEREZ MOLINA E. . Markovian Chemicals In Silico Design (MARCH_INSIDE), a Promising Approach for Computer-Aided Molecular Design I: Discovery of Anticancer Compounds. Journal of Molecular Modeling (Online) , v. 9, p. 395-407, 2003.

• URIARTE, E. . 3D-MEDNEs: An Alternative In silico Technique for Chemical Research in Toxicology. 1. Prediction of Chemically-induced Agranulocytosis. Chemical Research in Toxicology , v. 16, p. 1318-1327, 2003.

• URIARTE, E. . Quantitative Structure-Toxicity Relationships Using TOPS-MODE. 3. Structural factors Influencing the Permeability of Commercial Solvents Through Living Human Skin. SAR and QSAR in Environmental Research (Print) , v. 14, p. 145-163, 2003.

• SANTANA, L. ; URIARTE, E. . Regioselective Syntheis of Linear and Angular Pyridazine Furocoumarins. Synthesis (Stuttgart) , v. 1, p. 43-46, 2002.

• URIARTE, E. ; SANTANA, L. . Synthesis of Angular Pyrrolocoumarins. Synthesis (Stuttgart) , v. 4, p. 475-478, 2002.

• URIARTE, E. ; SANTANA, L. . Novel 1,2-disubstituted Carbocyclic Nucleoside Analogues of Purine with a Cyclopentene Ring. Synthesis (Stuttgart) , v. 16, p. 2445-2449, 2002.

• URIARTE, E. . A Cyclative Cleavage Approach to the Solid Phase Synthesis of 2-Oxo-1,4-piperazines. Synlett (Stuttgart) , v. 7, p. 1085-1088, 2002.

• URIARTE, E. . A Convenient Preparation of 4-Carboxamide Derivatives of Pyridazino[4,5-b]indoles and Pyridazino[4,5-b] benzo[b]furans. Synlett (Stuttgart) , v. 12, p. 2095-2097, 2002.

• URIARTE, E. ; SANTANA, L. . Synthesis and structure activity relationships of new arylpiperazines: para substitution with electron-withdrawing groups decrease binding to 5-HT1A and D2 receptors. European Journal of Medicinal Chemistry , v. 37, p. 503-510, 2002.

• URIARTE, E. ; SANTANA, L. . Synthesis, Conformational Analysis, and Antiviral and Antitumoral Activity of New 1,2-Disubstituted Carbocyclic Nucleosides. European Journal of Medicinal Chemistry , v. 37, p. 755-760, 2002.

• URIARTE, E. . In Silico Studies Toward the Discovery of new Anti-HIV Nucleoside Compounds with the use of TOPS-MODE and 2D/3D Connectivity Indices. 1. Pyrimidyl Derivatives. Journal of Chemical Information and Computer Sciences (Cessou em 2004. Cont. ISSN 1549-9596 Journal of Chemical Information and Modeling) , v. 42, p. 1194-1203, 2002.

• SANTANA, L. ; URIARTE, E. . Synthesis and Vasorelaxant Activity of new Coumarins and Furocoumarins Derivatives. Bioorganic & Medicinal Chemistry Letters (Print) , v. 12, p. 783-786, 2002.

• URIARTE, E. . Electrospray ionisation tandem mas spectrometry in the characterization of isomeric benzofurocoumarins. RCM. Rapid Communications in Mass Spectrometry , v. 15, p. 1000-1010, 2001.

• URIARTE, E. . Quantitative Structure-Activity Relationships using TOPS-MODE. 1. Nitrobenzene Toxicity to Tetrahymena pyriformis. SAR and QSAR in Environmental Research (Print) , v. 12, p. 309-324, 2001.

• SANTANA, L. ; URIARTE, E. . Synthesis of 1,2-Disubstituted Carbocyclic Analogues of Pyrimidine and Purine Nucleosides. Synthesis (Stuttgart) , v. 10, p. 1532-1538, 2001.

• URIARTE, E. . Recent Advances on the Role of Topological Indices in Drug Discovery Research. Current Medicinal Chemistry , v. 8, p. 1573-1588, 2001.

• SANTANA, L. ; URIARTE, E. . Resolution of racemic carbonucleosides and assignment of the absolute configuration by NMR. Tetrahedron: Asymmetry (Print) , v. 12, p. 2637-2639, 2001.

• PEREZ MOLINA E. ; URIARTE, E. . Quantitative Structure-Activity Relationships using TOPS-MODE. 2. Neurotoxicity of a Non-congeneric Series of Solvents. SAR and QSAR in Environmental Research (Print) , v. 12, p. 445-459, 2001.

• URIARTE, E. . A New Benzoangelicin with Strong Photobiological Activity. Bioorganic & Medicinal Chemistry Letters (Print) , v. 10, p. 135-137, 2000.

• URIARTE, E. . Synthesis of New 4-Cyclohexylcoumarin Derivatives. Synthesis (Stuttgart) , v. 5, p. 643-645, 2000.

• URIARTE, E. . A Novel Approach for the Virtual Screening and Rational Design of Anticancer Compounds. Journal of Medicinal Chemistry , v. 43, p. 249-256, 2000.

• SANTANA, L. ; URIARTE, E. . Design, Synthesis, Conformational Analysis and Biological Activities of Purine based 1,2-Disubstituted Carbocyclic Analogues. Chemical and Pharmaceutical Bulletin , v. 48, p. 293-295, 2000.

• URIARTE, E. ; SANTANA, L. . New Tetracyclic Analogues of Photochemotherapeutic Drugs 5-MOP and 8-MOP: Synthesis, DNA Interaction and Antiproliferative Activity. Journal of Medicinal Chemistry , v. 42, p. 4405-4413, 1999.

• SANTANA, L. ; URIARTE, E. . Benzofuran Analogues of Arylalcanoics Acids: AM1 Theoretical Study, Synthesis and Inhibitory Activity against Platelet Cyclo-oxygenase. European Journal of Pharmaceutical Sciences , v. 7, p. 161-166, 1999.

• URIARTE, E. ; SANTANA, L. . Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 2-amino-6-substituted purine and 8-azapurine. Bioorganic & Medicinal Chemistry Letters (Print) , v. 8, p. 1349-1352, 1998.

• URIARTE, E. . Synthesis and Mass Spectrometric Investigation of Some New Coumarin Derivatives. RCM. Rapid Communications in Mass Spectrometry , v. 12, p. 2041-2046, 1998.

• URIARTE, E. . Preliminary study of the potential vasodilatador effects on Rat Aorta of Centaurein and Centaureidin, two Flavonoids from Centaurea Corcubionensis. Planta Medica , v. 64, p. 116-119, 1998.

• URIARTE, E. . Desymetrisation of Bicyclic, Meso-Anhydrides by Proline Esters. Tetrahedron Letters , v. 38, p. 889-892, 1997.

• URIARTE, E. . Synthesis and Mass Spectrometric Behaviour of Some New Nucleoside Analogues with Potential Chemotherapeutic Activity. RCM. Rapid Communications in Mass Spectrometry , v. 11, p. 774-780, 1997.

• URIARTE, E. ; SANTANA, L. . Synthesis of Angular and Linear Benzofurocoumarins. Synthesis (Stuttgart) , v. 12, p. 1384-1386, 1997.

• URIARTE, E. . Peptidil Anthraquinones as Potential Antineoplastic Drugs: Synthesis, DNA-Binding, Redox Cycling and Biological Activity. Journal of Medicinal Chemistry , v. 39, p. 3114-3122, 1996.

• URIARTE, E. . 4'-Methyl Derivatives of 5-MOP and 5-MOA: Synthesis, Photoreactivity and Photobiological Activity. Journal of Medicinal Chemistry , v. 39, p. 4489-4496, 1996.

• URIARTE, E. . Desymmetrisation of meso-Anhydrides Utilising (S)-Proline Derivatives. Synthesis (Stuttgart) , v. 3, p. 393-398, 1996.

• SANTANA, L. ; URIARTE, E. . Electron Impact Mass Spectrometry of Some Potential Anti-HIV Nucleosides. RCM. Rapid Communications in Mass Spectrometry , v. 10, p. 1316-1318, 1996.

• SANTANA, L. ; URIARTE, E. . A Convenient Synthesis of Benzofuran-3-acetic Acids. Heterocycles (Sendai) , v. 41, p. 647-650, 1995.

• URIARTE, E. . Synthesis and Characterization of New Methylpsoralens as Potential Photochemotherapeutic Agents. Il Farmaco (Pavia) (Cessou em 2005) , v. 49, p. 277-280, 1994.

• URIARTE, E. . Synthesis and Biological Activity of New Quinolone Derivatives. European Journal of Medicinal Chemistry , v. 28, p. 291-296, 1993.

• URIARTE, E. . Synthesis and Photobiological Activity of new Methylpsoralen derivatives. Journal of Photochemistry and Photobiology. B, Biology , v. 14, p. 95-104, 1992.

• URIARTE, E. . Dehydroophioxanthin, a new Acetilenic Carotenoid Sulfate from the Ophiuroid Ophiocomona nigra. Journal of Natural Products (Print) , v. 54, p. 606-608, 1991.

• URIARTE, E. . Starfish Saponins, Part 41. Structure of two new Steroidal Glycoside Sulfates (Miniatosides A and B) and two new Polyhydroxyesteroids from the Starfish Patiria miniata. Journal of Natural Products (Print) , v. 53, p. 94-101, 1990.

• URIARTE, E. . Isolation and estructure elucidation of seven new polyhydroxylated sulfated sterols from the ophiuroid Ophiolepis superba. Journal of Organic Chemistry , v. 54, p. 234-239, 1989.

• URIARTE, E. . Protein Graphs in Cancer Prediction. An Omics Perspective on Cancer Research. : Springer Science+Busines Media, 2010, v. , p. 125-140.

• MATOS, M. J. ; URIARTE, E. ; SANTANA, L. . Synthesis and Study of a Series of 3-Arylcoumarins as Potent > and Selective MAO-B Inhibitors. Journal of Medicinal Chemistry , 2011.

• PEREZ MOLINA E. ; URIARTE, E. ; SANTANA, L. . QSAR and Complex Network Recognition of miRNAs in Stem Cells. Current Bioinformatics (Print) , 2011.

• MATOS, M. J. ; URIARTE, E. . An alternative scaffold on a neurodegenerative diseases: Differently substituted coumarins as MAO-B selective and potent inhibitors. 2011. (Apresentação de Trabalho/Congresso).

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Differently substituted coumarins as antimicrobial agents. 2011. (Apresentação de Trabalho/Simpósio).

• MATOS, M. J. ; URIARTE, E. ; SANTANA, L. . Dual AChE/MAO-B inhibitory agents: A New approach to the treatmenet of neurodegenerative diseases. 2011. (Apresentação de Trabalho/Congresso).

• MATOS, M. J. ; URIARTE, E. . Alternative methodologies for the synthesis of substituted 3-arylcoumarins: Perkin reactions and palladium-catalyzed synthesis. 2010. (Apresentação de Trabalho/Outra).

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Rational design and synthesis of coumarin-chalcone derivatives as chemotherapeutic agent. 2010. (Apresentação de Trabalho/Simpósio).

• URIARTE, E. ; MATOS, M. J. ; SANTANA, L. . Versatilidade de metodologías sintéticas na preparação de séries de cumarinas 3-substituídas. 2010. (Apresentação de Trabalho/Simpósio).

• MATOS, M. J. ; URIARTE, E. . Electrochemical study of a new series of coumarins. 2010. (Apresentação de Trabalho/Outra).

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Synthesis and iMAO evaluation of bromo derivative 3-phenylcoumarins. 2009. (Apresentação de Trabalho/Simpósio).

• SANTANA, L. ; URIARTE, E. . Coumarin-Chalcone Hybrids as new scaffolds in drug discovery. 2009. (Apresentação de Trabalho/Outra).

• MATOS, M. J. ; URIARTE, E. ; SANTANA, L. . Synthesis and pharmacological evaluation of coumarins as new scaffold on the Parkinson's disease. 2009. (Apresentação de Trabalho/Outra).

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Synyhesis of new 3,4-benzo(cycloalkyl) coumarins as MAO inhibitors. 2008. (Apresentação de Trabalho/Simpósio).

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Synthesis of new coumarin derivatives with pharmacological activity. 2008. (Apresentação de Trabalho/Simpósio).

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Design, Synthesis and Pharmacological Evaluation of New Coumarin Derivatives as Monoamine Oxidase A and B Inhibitors. 2008. (Apresentação de Trabalho/Outra).

• URIARTE, E. ; SANTANA, L. . Pyridazinofurocoumarins: A New Class of Photochemotherapeutic Agents. 2007. (Apresentação de Trabalho/Congresso).

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . Resveratrol and coumarins- New hybrid compounds. 2007. (Apresentação de Trabalho/Congresso).

• SANTANA, L. ; URIARTE, E. . QSAR & Network-based multi-species activity models for antifungals. 2007. (Apresentação de Trabalho/Outra).

• SANTANA, L. ; URIARTE, E. . Unify QSAR approach to antibacterial activity of organic drugs against different species. 2006. (Apresentação de Trabalho/Congresso).

• MATOS, M. J. ; SANTANA, L. ; URIARTE, E. . QSAR, synthesis and in silico and in vitro vasodilatory evaluation of resveratrol-coumarin hybrids. 2006. (Apresentação de Trabalho/Congresso).

• SANTANA, L. ; URIARTE, E. . Sintesi di un híbrido cumarina-resveratrolo. 2005. (Apresentação de Trabalho/Congresso).

• PEREZ MOLINA E. ; URIARTE, E. . Methodology describing physico-chemical properties of amino.acids. 2004. (Apresentação de Trabalho/Outra).

• SANTANA, L. ; URIARTE, E. . Synthesis of turocoumarins from asymetric dipyrones. 2004. (Apresentação de Trabalho/Simpósio).

• SANTANA, L. ; URIARTE, E. . Benzopsoralenos con potente actividad fotobiológica. 2003. (Apresentação de Trabalho/Congresso).

• SANTANA, L. ; URIARTE, E. . Análogos carbocíclicos de nucleosidos pirimidínicos derivados de ciclohexano 1,2-disustituidos. 2003. (Apresentação de Trabalho/Congresso).

• URIARTE, E. . Inhibitory effects of cis-resveratrol, a natural component of wine, on NADH/NADPH oxydase enzymatic activity in rat aortic homogenates. 2002. (Apresentação de Trabalho/Congresso).

• SANTANA, L. ; URIARTE, E. . Purine Derivatives of 1,2-Disubstituted Cyclohexane Analogues of Nucleosides. 2002. (Apresentação de Trabalho/Congresso).

• SANTANA, L. ; URIARTE, E. . Dipyranobenzene and Difurobenzene Analogues of Furocoumarins. 2002. (Apresentação de Trabalho/Simpósio).

• SANTANA, L. ; URIARTE, E. . Diseño, síntesis y actividad dopaminérgica y serotoninérgica de nuevas piperazinas disubstituidas. Relación estructura-actividad. 2001. (Apresentação de Trabalho/Congresso).

• URIARTE, E. . Synthesis of Putative Metabolites of 3,4-Methylenedioxymethamphetamine (Ecstasy. 2001. (Apresentação de Trabalho/Simpósio).

• SANTANA, L. ; URIARTE, E. . Preparaçao de Isósteros Nitrogenados de Benzoangelicinas. 2001. (Apresentação de Trabalho/Congresso).

• URIARTE, E. . Synthesis of Benzoangelicin Isosters as Potential Photochemotherapeutic Agents. 2000. (Apresentação de Trabalho/Simpósio).

• URIARTE, E. . Resolution of racemic mixtures of carbocyclic analogues of nucleosides, and assignment of their absolute configurations. 2000. (Apresentação de Trabalho/Simpósio).

• PEREZ MOLINA E. ; URIARTE, E. ; SANTANA, L. . In Silico Studies for the Screening and Design of Pharmacologically Active Compounds. 2000. (Apresentação de Trabalho/Simpósio).

Projetos de pesquisa

• 2009 - 2012

  Estudio de los efectos beneficiosos de polifenoles análogos de resveratrol y flavonoides en enfermedades relacionadas con el envejecimiento, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 2009 - 2012

  Deseño, sintese e estudo de novas cumarinas como axentes neuroprotectores, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 2006 - 2009

  Estudio de los efectos cardioprotectores de polifenoles analogos de resveratrol y flavonoides, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 2005 - 2008

  Síntesis y estudio de nuevas cumarinas, furocumarinas y derivados tetracíclicos de cumarinas con interés farmacológico.3, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 2005 - 2008

  Síntesis y estudio de los efectos cardiovasculares y antitrombóticos de diversos derivados del resveratrol (III), Situação: Concluído; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 2003 - 2004

  Síntesis y estudio de nuevas cumarinas, furocumarinas y derivados tetracíclicos de cumarinas con interés farmacológico.2, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 2002 - 2005

  Síntesis e estudio dos efectos cardiovasculares e antitrombóticos de diversos derivados de resveratrol, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 2000 - 2003

  Síntesis y estudio de nuevas cumarinas, furocumarinas y análogos tetracíclicos de cumarinas con interés farmacológico, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 2000 - 2001

  Síntesis e estudio de novas cumarinas, furocumarinas e análogos tetracíclicos de cumarinas con actividade farmacolóxica, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 1995 - 1996

  Sintesis y estudio de análogos de nucleósidos antivirales y antitumorales, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

• 1993 - 1994

  Nuevas antraquinonas como agentes anticancerígenos selectivos, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Eugenio Uriarte Villares - Coordenador.

Projetos de desenvolvimento

• 1998 - 2000

  Síntesis y estudio de nuevas furocumarinas como agentes fotoquimioterápicos, Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Eugenio Uriarte Villares - Coordenador.