Artur Manuel Cavaco Paulo

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Áreas de atuação

Orientou

Produções bibliográficas

• Silva, Raquel ; Ferreira, Helena ; Carvalho, Ana C. ; Gomes, Andreia C. ; Cavaco-Paulo, Artur . Protein microspheres as suitable devices for piroxicam release. Colloids and Surfaces. B, Biointerfaces (Print) , v. 92, p. 277-285, 2012.

• Barros, Sandra Cerqueira ; Martins, José Alberto ; Marcos, João Carlos ; Cavaco-Paulo, Artur . Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications. Enzyme and Microbial Technology , v. 50, p. 107-114, 2012.

• Cavaco-Paulo, Artur ; M. Guebizt, Georg ; Freddi, Giuliano . Editorial. Biocatalysis and Biotransformation (Print) , v. 30, p. 1-1, 2012.

• GonÇalves, Idalina ; Silva, Carla ; Cavaco-Paulo, Artur . Decolourization of paprika dye effluent with hydrogen peroxide produced by glucose oxidase. Biocatalysis and Biotransformation (Print) , v. 30, p. 255-259, 2012.

• Caparrós, Cristina ; Lant, Neil ; Smets, Johan ; Cavaco-Paulo, Artur . Effects of adsorption properties and mechanical agitation of two detergent cellulases towards cotton cellulose. Biocatalysis and Biotransformation (Print) , v. 30, p. 260-271, 2012.

• Fernandes, Margarida M. ; Silva, Raquel ; Ferreira, Helena ; Donelli, Ilaria ; Freddi, Giuliano ; Cavaco-Paulo, Artur . Protein disulphide isomerase-induced refolding of sonochemically prepared Ribonuclease A microspheres. Journal of Biotechnology , v. 159, p. 78-82, 2012.

• Martí, Meritxell ; Cavaco-Paulo, Artur . Laccases stabilization with phosphatidylcholine liposomes. Journal of Biophysical Chemistry , v. 03, p. 81-87, 2012.

• Fu, Jiajia ; Li, Xiaoqiang ; Gao, Weidong ; Wang, Hongbo ; Cavaco-Paulo, Artur ; Silva, Carla . Bio-processing of bamboo fibres for textile applications: a mini review. Biocatalysis and Biotransformation (Print) , v. 30, p. 141-153, 2012.

• Fernandes, Margarida M. ; Cavaco-Paulo, Artur . Protein disulphide isomerase-assisted functionalization of proteinaceous substrates. Biocatalysis and Biotransformation (Print) , v. 30, p. 111-124, 2012.

• Azoia, Nuno G. ; Fernandes, Margarida M. ; Micaêlo, Nuno M. ; Soares, Cláudio M. ; Cavaco-Paulo, Artur . Molecular modeling of hair keratin/peptide complex: Using MM-PBSA calculations to describe experimental binding results. Proteins (Print) , v. 80, p. 1409-1417, 2012.

• Tzhayik, Oshrat ; Cavaco-Paulo, Artur ; Gedanken, Aharon . Fragrance release profile from sonochemically prepared protein microsphere containers. Ultrasonics Sonochemistry , v. 19, p. 858-863, 2012.

• Silva, Raquel ; Ferreira, Helena ; Carvalho, Ana C. ; Gomes, Andreia C. ; Cavaco-Paulo, Artur . Protein microspheres as suitable devices for piroxicam release. Colloids and Surfaces. B, Biointerfaces (Print) , v. 92, p. 277-285, 2012.

• Barros, Sandra Cerqueira ; Martins, José Alberto ; Marcos, João Carlos ; Cavaco-Paulo, Artur . Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications. Enzyme and Microbial Technology , v. 50, p. 107-114, 2012.

• Fernandes, Margarida ; Cavaco-Paulo, Artur . Protein disulphide isomerase-mediated grafting of cysteine-containing peptides onto over-bleached hair. Biocatalysis and Biotransformation (Print) , v. 30, p. 10-19, 2012.

• Caparrós, Cristina ; López, Carmen ; Torrell, Marc ; Lant, Neil ; Smets, Johan ; Cavaco-Paulo, Artur . Treatment of cotton with an alkaline Bacillus spp cellulase: Activity towards crystalline cellulose. Biotechnology Journal (Print) , v. 7, p. 275-283, 2012.

• Kim, Suyeon ; Cavaco-Paulo, Artur . Laccase-catalysed protein flavonoid conjugates for flax fibre modification. Applied Microbiology and Biotechnology , v. 93, p. 585-600, 2012.

• Fu, Jiajia ; Nyanhongo, Gibson S. ; Silva, Carla ; Cardinale, Massimiliano ; Prasetyo, Endry Nugroho ; Yu, Chongwen ; Cavaco-Paulo, Artur ; Gübitz, Georg M. . Bamboo fibre processing: insights into hemicellulase and cellulase substrate accessibility. Biocatalysis and Biotransformation (Print) , v. 30, p. 27-37, 2012.

• FERNANDES, M. M. ; GOMES, A. C. ; VASCONCELOS, A. ; MUNTEANU, F. D. ; TZANOV, T. ; GONCALVES, M. S. T. ; END, N. ; SCHOENING, K. U. ; GÜBITZ, G. ; Cavaco-Paulo, Artur . PROTEIN DISULPHIDE ISOMERASE-ASSISTED FUNCTIONALIZATION OF KERATIN-BASED MATRICES. Applied Microbiology and Biotechnology , v. 90, p. 1311-1321, 2011.

• VASCONCELOS, A. ; Cavaco-Paulo, Artur . WOUND DRESSINGS FOR A PROTEOLYTIC-RICH ENVIRONMENT. Applied Microbiology and Biotechnology , v. 90, p. 445-460, 2011.

• KIM, S ; silva c ; Evtuguin, D V ; Cavaco-Paulo, Artur . POLYOXOMETALATE/LACCASE-MEDIATED OXIDATIVE POLYMERIZATION OF CATECHOL FOR TEXTILE DYEING. Applied Microbiology and Biotechnology , v. 89, p. 981-987, 2011.

• Shimanovich, Ulyana ; Tkacz, Itai Dov ; Eliaz, Dror ; Cavaco-Paulo, Artur ; Michaeli, Shulamit ; Gedanken, Aharon . Encapsulation of RNA Molecules in BSA Microspheres and Internalization into Trypanosoma Brucei Parasites and Human U2OS Cancer Cells. Advanced Functional Materials (Print) , v. 21, p. 3659-3666, 2011.

• Silva, Raquel ; Ferreira, Helena ; Cavaco-Paulo, Artur . Sonoproduction of Liposomes and Protein Particles as Templates for Delivery Purposes. Biomacromolecules , v. 12, p. 3353-3368, 2011.

• Herrero Acero, Enrique ; Ribitsch, Doris ; Steinkellner, Georg ; Gruber, Karl ; Greimel, Katrin ; Eiteljoerg, Inge ; Trotscha, Eva ; Wei, Ren ; Zimmermann, Wolfgang ; Zinn, Manfred ; Cavaco-Paulo, Artur ; Freddi, Giuliano ; Schwab, Helmut ; Guebitz, Georg . Enzymatic Surface Hydrolysis of PET: Effect of Structural Diversity on Kinetic Properties of Cutinases from Thermobifida. Macromolecules (Print) , v. 44, p. 4632-4640, 2011.

• Vasconcelos, Andreia ; Azoia, Nuno G. ; Carvalho, Ana C. ; Gomes, Andreia C. ; Güebitz, Georg ; Cavaco-Paulo, Artur . Tailoring elastase inhibition with synthetic peptides. European Journal of Pharmacology , v. 666, p. 53-60, 2011.

• Silva, Carla ; Matamá, Teresa ; Kim, Suyeon ; Padrão, Jorge ; Nugroho Prasetyo, Endry ; Kudanga, Tukayi ; Nyanhongo, Gibson S. ; Guebitz, Georg M. ; Casal, Margarida ; Cavaco-Paulo, Artur . Antimicrobial and antioxidant linen via laccase-assisted grafting. Reactive & Functional Polymers (Print) , v. 71, p. 713-720, 2011.

• Silva, Carla ; Da, Shi ; Silva, Nádia ; Matamá, Teresa ; Araújo, Rita ; Martins, Madalena ; Chen, Sheng ; Chen, Jian ; Wu, Jing ; Casal, Margarida ; Cavaco-Paulo, Artur . Engineered Thermobifida fusca cutinase with increased activity on polyester substrates. Biotechnology Journal (Print) , v. 6, p. 1230-1239, 2011.

• Guimarães, Clara ; Kim, Suyeon ; Silva, Carla ; Cavaco-Paulo, Artur . In situ laccase-assisted overdyeing of denim using flavonoids. Biotechnology Journal (Print) , v. 6, p. 1272-1279, 2011.

• Fu, Jiajia ; Mueller, Henry ; de Castro, Joao V ; Yu, Chonewen ; Cavaco-Paulo, Artur ; Guebitz, Georg M. ; Nyanhongo, Gibson S. . Changes in the bacterial community structure and diversity during bamboo retting. Biotechnology Journal (Print) , v. 6, p. 1262-1271, 2011.

• Fernandes, Margarida M. ; Gomes, Andreia C. ; Vasconcelos, Andreia ; Munteanu, Florentina-Daniela ; Tzanov, Tzanko ; Gonà alves, Maria Sameiro T. ; End, Nicole ; Schoening, Kai-Uwe ; Guebitz, Georg M. ; Cavaco-Paulo, Artur . Protein disulphide isomerase-assisted functionalization of keratin-based matrices. Applied Microbiology and Biotechnology , v. 90, p. 1311-1321, 2011.

• Vasconcelos, Andreia ; Cavaco-Paulo, Artur . Wound dressings for a proteolytic-rich environment. Applied Microbiology and Biotechnology , v. 90, p. 445-460, 2011.

• Kim, Suyeon ; Silva, Carla ; Evtuguin, Dmitry V. ; Gamelas, Josà A. F. ; Cavaco-Paulo, Artur . Polyoxometalate/laccase-mediated oxidative polymerization of catechol for textile dyeing. Applied Microbiology and Biotechnology , v. 89, p. 981-987, 2011.

• PRASETYO, E. N. ; KUDANGA, T. ; stergaard, L. ; Rencoret, J. ; Gutiérrez, A. ; del Río, J.C. ; Santos, J.I. ; NIETO, L. ; JIMENEZ-BARBERO, J. ; MARTÍNEZ, A.T. ; LI, J. ; GELLERSTEDT, G. ; LEPIFRE, S. ; silva c ; KIM, S ; Cavaco-Paulo, Artur ; KLAUSEN, B.S. ; LUTNAES, B.F. ; NYANHONGO, G.S. ; GUEBITZ, G. M. . POLYMERISATION OF LIGNOSULFONATES BY THE LACCASE-HBT(1-HYDROXYBENZOTRIAZOLE) SYSTEM IMPROVES DISPERSIBILITY. Bioresource Technology , v. 101, p. 5054-5062, 2010.

• Nugroho Prasetyo, Endry ; Kudanga, Tukayi ; à stergaard, Lars ; Rencoret, Jorge ; Gutià rrez, Ana ; del Rà o, Josà C. ; Ignacio Santos, J. ; Nieto, Lidia ; Jimà nez-Barbero, Jesús ; Martà nez, Angel T. ; Cavaco-Paulo, Artur . Polymerization of lignosulfonates by the laccase-HBT (1-hydroxybenzotriazole) system improves dispersibility. Bioresource Technology , v. 101, p. 5054-5062, 2010.

• Vasconcelos, Andreia ; Pe go, Ana Paula ; Henriques, Lara ; Lamghari, Meriem ; Cavaco-Paulo, Artur . Protein Matrices for Improved Wound Healing: Elastase Inhibition by a Synthetic Peptide Model. Biomacromolecules , v. 11, p. 2213-2220, 2010.

• Angel Shimanovich, Ulyana ; Silva, Carla Manuela ; Cavaco-Paulo, Artur ; Gedanken, Aharon . Attaching Different Kinds of Proteinaceous Nanospheres to a Variety of Fabrics Using Ultrasound Radiation. Israel Journal of Chemistry , v. 50, p. 524-529, 2010.

• Zhang, Y. ; Chen, S. ; Xu, M. ; Cavoco-Paulo, A. ; Wu, J. ; Chen, J. ; Cavaco-Paulo, Artur . Characterization of Thermobifida fusca Cutinase-Carbohydrate-Binding Module Fusion Proteins and Their Potential Application in Bioscouring. Applied and Environmental Microbiology (Print) , v. 76, p. 6870-6876, 2010.

• Munteanu, Florentina-Daniela ; Cavaco-Paulo, Artur . Biosensors Based on Laccase for Detection of Commercially Reactive Dyes. Analytical Letters , v. 43, p. 1126-1131, 2010.

• Matam , Teresa ; Ara jo, Rita ; G bitz, Georg M. ; Casal, Margarida ; Cavaco-Paulo, Artur . Functionalization of cellulose acetate fibers with engineered cutinases. Biotechnology Progress (Print) , v. 26, p. 636-643, 2010.

• Franciscon, Elisangela ; Piubeli, Francine ; Fantinatti-Garboggini, Fabiana ; Ragagnin de Menezes, Cristiano ; Serrano Silva, Isis ; Cavaco-Paulo, Artur ; Grossman, Matthew James ; Durrant, Lucia Regina . Polymerization study of the aromatic amines generated by the biodegradation of azo dyes using the laccase enzyme. Enzyme and Microbial Technology , v. 46, p. 360-365, 2010.

• Angel (Shimanovich), Ulyana ; Matas, Devorah ; Michaeli, Shulamit ; Cavaco-Paulo, Artur ; Gedanken, Aharon . Microspheres of Mixed Proteins. Chemistry (Weinheim. Print) , v. 16, p. 2108-2114, 2010.

• Silva, Raquel ; Ferreira, Helena ; Little, Collin ; Cavaco-Paulo, Artur . Effect of ultrasound parameters for unilamellar liposome preparation. Ultrasonics Sonochemistry , v. 17, p. 628-632, 2010.

• Brissos, Vânia ; Pereira, Luciana ; Munteanu, Florentina-Daniela ; Cavaco-Paulo, Artur ; Martins, Lígia O. . Expression system of CotA-laccase for directed evolution and high-throughput screenings for the oxidation of high-redox potential dyes. Biotechnology Journal (Print) , v. 4, p. 558-563, 2009.

• Heumann, Sonja ; Eberl, Anita ; Fischer-Colbrie, Gudrun ; Pobeheim, Herbert ; Kaufmann, Franz ; Ribitsch, Doris ; Cavaco-Paulo, Artur ; Guebitz, Georg M. . A novel aryl acylamidase from hydrolyses polyamide. Biotechnology and Bioengineering (Print) , v. 102, p. 1003-1011, 2009.

• Elisangela, Franciscon ; Andrea, Zille ; Fabio, Dias Guimaro ; de Menezes Cristiano, Ragagnin ; Regina, Durrant Lucia ; Artur, Cavaco-Paulo ; Cavaco-Paulo, Artur . Biodegradation of textile azo dyes by a facultative Staphylococcus arlettae strain VN-11 using a sequential microaerophilic/aerobic process. International Biodeterioration & Biodegradation , v. 63, p. 280-288, 2009.

• Franciscon, Elisangela ; Zille, Andrea ; Fantinatti-Garboggini, Fabiana ; Silva, Isis Serrano ; Cavaco-Paulo, Artur ; Durrant, Lucia Regina . Microaerophilicâ "aerobic sequential decolourization/biodegradation of textile azo dyes by a facultative Klebsiella sp. strain VN-31. Process Biochemistry (1991) , v. 44, p. 446-452, 2009.

• Arau jo, Rita ; Silva, Carla ; Machado, Raul ; Casal, Margarida ; Cunha, Anto nio M. ; Rodriguez-Cabello, José Carlos ; Cavaco-Paulo, Artur . Proteolytic Enzyme Engineering: A Tool for Wool. Biomacromolecules , v. 10, p. 1655-1661, 2009.

• Kim, Suyeon ; Silva, Carla ; Zille, Andrea ; Lopez, Carmen ; Evtuguin, Dmitry V ; Cavaco-Paulo, Artur . Characterisation of enzymatically oxidised lignosulfonates and their application on lignocellulosic fabrics. Polymer International , v. 58, p. 863-868, 2009.

• Eberl, Anita ; Heumann, Sonja ; Brückner, Tina ; Araujo, Rita ; Cavaco-Paulo, Artur ; Kaufmann, Franz ; Kroutil, Wolfgang ; Guebitz, Georg M. . Enzymatic surface hydrolysis of poly(ethylene terephthalate) and bis(benzoyloxyethyl) terephthalate by lipase and cutinase in the presence of surface active molecules. Journal of Biotechnology , v. 143, p. 207-212, 2009.

• Guebitz, Georg M. ; Cavaco-Paulo, Artur . Enzymes go big: surface hydrolysis and functionalisation of synthetic polymers. Trends in Biotechnology (Regular ed.) , v. 26, p. 32-38, 2008.

• Eberl, A. ; Heumann, S. ; Kotek, R. ; Kaufmann, F. ; Mitsche, S. ; Cavaco-Paulo, A. ; Gübitz, G.M. ; Cavaco-Paulo, Artur . Enzymatic hydrolysis of PTT polymers and oligomers. Journal of Biotechnology , v. 135, p. 45-51, 2008.

• Munteanu, Florentina-Daniela ; Ferreira, Patricia ; Ruiz-Dueñas, Francisco J. ; Martínez, Angel T. ; Cavaco-Paulo, Artur . Bioelectrochemical investigations of aryl-alcohol oxidase from Pleurotus eryngii. Journal of Electroanalytical Chemistry (1992) , v. 618, p. 83-86, 2008.

• Silva, Raquel ; Little, Collin ; Ferreira, Helena ; Cavaco-Paulo, Artur . Incorporation of peptides in phospholipid aggregates using ultrasound. Ultrasonics Sonochemistry , v. 15, p. 1026-1032, 2008.

• Cavaco-Paulo, Artur . Textile Biotechnology. Biocatalysis and Biotransformation (Print) , v. 26, p. 331-331, 2008.

• Araújo, Rita ; Casal, Margarida ; Cavaco-Paulo, Artur . Application of enzymes for textile fibres processing. Biocatalysis and Biotransformation (Print) , v. 26, p. 332-349, 2008.

• Silva, Carla ; Cavaco-Paulo, Artur . Biotransformations in synthetic fibres. Biocatalysis and Biotransformation (Print) , v. 26, p. 350-356, 2008.

• ALMANSA, E. ; Heumann, S. ; Eberl, A. ; Fischer-Colbrie, G. ; Martinkova, L. ; Marek, J. ; Cavaco-Paulo, A. ; GUEBITZ, G. M. ; Cavaco-Paulo, Artur . Enzymatic surface hydrolysis of PET enhances bonding in PVC coating. Biocatalysis and Biotransformation (Print) , v. 26, p. 365-370, 2008.

• ALMANSA, E. ; Heumann, S. ; Eberl, A. ; Kaufmann, F. ; Cavaco-Paulo, A. ; Gübitz, G. M. ; Cavaco-Paulo, Artur . Surface hydrolysis of polyamide with a new polyamidase from. Biocatalysis and Biotransformation (Print) , v. 26, p. 371-377, 2008.

• Vasconcelos, Andreia ; Freddi, Giuliano ; Cavaco-Paulo, Artur . Biodegradable Materials Based on Silk Fibroin and Keratin. Biomacromolecules , v. 9, p. 1299-1305, 2008.

• Araújo, R. ; Cavaco Paulo, A. ; Casal, M. ; Cavaco-Paulo, Artur . Strategies towards the Functionalization of Subtilisin E from Bacillus subtilis for Wool Finishing Applications. Engineering in Life Sciences (Print) , v. 8, p. 238-249, 2008.

• López, C. ; Cavaco Paulo, A. ; Cavaco-Paulo, Artur . In situ Enzymatic Generation of Hydrogen Peroxide for Bleaching Purposes. Engineering in Life Sciences (Print) , v. 8, p. 315-323, 2008.

• Kim, S. ; López, C. ; Güebitz, G. ; Cavaco Paulo, A. ; Cavaco-Paulo, Artur . Biological Coloration of Flax Fabrics with Flavonoids using Laccase from Trametes hirsuta. Engineering in Life Sciences (Print) , v. 8, p. 324-330, 2008.

• Cavaco-Paulo, Artur ; Gübitz, Georg . Editorial: Textile biotech. Biotechnology Journal (Print) , v. 2, p. 281-281, 2007.

• Ramalho, Patrícia A. C. F. ; Cardoso, M. Helena ; Ramalho, M. Teresa ; Gübitz, Georg M. ; Cavaco-Paulo, Artur M. ; Cavaco-Paulo, Artur . Decolourisation of a synthetic textile effluent using a bacterial consortium. Biotechnology Journal (Print) , v. 2, p. 370-373, 2007.

• Matamá, Teresa ; Carneiro, Filipa ; Caparrós, Cristina ; Gübitz, Georg M. ; Cavaco-Paulo, Artur . Using a nitrilase for the surface modification of acrylic fibres. Biotechnology Journal (Print) , v. 2, p. 353-360, 2007.

• Basto, Carlos ; Tzanov, Tzanko ; Cavaco-Paulo, Artur . Combined ultrasound-laccase assisted bleaching of cotton. Ultrasonics Sonochemistry , v. 14, p. 350-354, 2007.

• Basto, Carlos ; Silva, Carla Joana ; Gübitz, Georg ; Cavaco-Paulo, Artur . Stability and decolourization ability of Trametes villosa laccase in liquid ultrasonic fields. Ultrasonics Sonochemistry , v. 14, p. 355-362, 2007.

• Munteanu, Florentina-Daniela ; Basto, Carlos ; Gübitz, Georg M. ; Cavaco-Paulo, Artur . Staining of wool using the reaction products of ABTS oxidation by Laccase: Synergetic effects of ultrasound and cyclic voltammetry. Ultrasonics Sonochemistry , v. 14, p. 363-367, 2007.

• Fischer-Colbrie, Gudrun ; Matama, Teresa ; Heumann, Sonja ; Martinkova, Ludmila ; Cavaco Paulo, Artur ; Guebitz, Georg ; Cavaco-Paulo, Artur . Surface hydrolysis of polyacrylonitrile with nitrile hydrolysing enzymes from Micrococcus luteus BST20. Journal of Biotechnology , v. 129, p. 62-68, 2007.

• Araújo, Rita ; Silva, Carla ; O Neill, Alexandre ; Micaelo, Nuno ; Guebitz, Georg ; Soares, Cláudio M. ; Casal, Margarida ; Cavaco-Paulo, Artur . Tailoring cutinase activity towards polyethylene terephthalate and polyamide 6,6 fibers. Journal of Biotechnology , v. 128, p. 849-857, 2007.

• Cavaco-Paulo, Artur ; Gubitz, Georg . Editorial. Enzyme and Microbial Technology , v. 40, p. 1645, 2007.

• Todorova, Snezhana Bogomilova ; Silva, Carla J.S.M. ; Simeonov, Nikolay Petkov ; Cavaco-Paulo, Artur . Cotton fabric: A natural matrix suitable for controlled release systems. Enzyme and Microbial Technology , v. 40, p. 1646-1650, 2007.

• Shen, Jinsong ; Rushforth, Mike ; Cavaco-Paulo, Artur ; Guebitz, Georg ; Lenting, Herman . Development and industrialisation of enzymatic shrink-resist process based on modified proteases for wool machine washability. Enzyme and Microbial Technology , v. 40, p. 1656-1661, 2007.

• Silva, Carla ; Araújo, Rita ; Casal, Margarida ; Gübitz, Georg M. ; Cavaco-Paulo, Artur . Influence of mechanical agitation on cutinases and protease activity towards polyamide substrates. Enzyme and Microbial Technology , v. 40, p. 1678-1685, 2007.

• Pricelius, S. ; Held, C. ; Sollner, S. ; Deller, S. ; Murkovic, M. ; Ullrich, R. ; Hofrichter, M. ; Cavaco-Paulo, A. ; Macheroux, P. ; Guebitz, G.M. ; Cavaco-Paulo, Artur . Enzymatic reduction and oxidation of fibre-bound azo-dyes. Enzyme and Microbial Technology , v. 40, p. 1732-1738, 2007.

• Schnitzhofer, W. ; Weber, H.-J. ; Vr anská, M. ; Biely, P. ; Cavaco-Paulo, A. ; Guebitz, G.M. ; Cavaco-Paulo, Artur . Purification and mechanistic characterisation of two polygalacturonases from Sclerotium rolfsii. Enzyme and Microbial Technology , v. 40, p. 1739-1747, 2007.

• Schroeder, M. ; Pereira, L. ; Couto, Susana Rodríguez ; Erlacher, A. ; Schoening, K.-U. ; Cavaco-Paulo, A. ; Guebitz, G.M. ; Cavaco-Paulo, Artur . Enzymatic synthesis of Tinuvin. Enzyme and Microbial Technology , v. 40, p. 1748-1752, 2007.

• Sousa, Fernanda ; Jus, Susana ; Erbel, Anita ; Kokol, Vanja ; Cavaco-Paulo, Artur ; Gubitz, G.M. . A novel metalloprotease from Bacillus cereus for protein fibre processing. Enzyme and Microbial Technology , v. 40, p. 1772-1781, 2007.

• Kim, S.Y. ; Zille, A. ; Murkovic, M. ; Güebitz, G. ; Cavaco-Paulo, A. ; Cavaco-Paulo, Artur . Enzymatic polymerization on the surface of functionalized cellulose fibers. Enzyme and Microbial Technology , v. 40, p. 1782-1787, 2007.

• Kim, Suyeon ; Moldes, Diego ; Cavaco-Paulo, Artur . Laccases for enzymatic colouration of unbleached cotton. Enzyme and Microbial Technology , v. 40, p. 1788-1793, 2007.

• O Neill, Alexandre ; Araújo, Rita ; Casal, Margarida ; Guebitz, Georg ; Cavaco-Paulo, Artur . Effect of the agitation on the adsorption and hydrolytic efficiency of cutinases on polyethylene terephthalate fibres. Enzyme and Microbial Technology , v. 40, p. 1801-1805, 2007.

• Silva, Carla ; Silva, Carla Joana ; Zille, Andrea ; Guebitz, Georg M. ; Cavaco-Paulo, Artur . Laccase immobilization on enzymatically functionalized polyamide 6,6 fibres. Enzyme and Microbial Technology , v. 41, p. 867-875, 2007.

• Pricelius, S. ; Held, C. ; Murkovic, M. ; Bozic, M. ; Kokol, V. ; Cavaco-Paulo, A. ; GUEBITZ, G. M. ; Cavaco-Paulo, Artur . Enzymatic reduction of azo and indigoid compounds. Applied Microbiology and Biotechnology , v. 77, p. 321-327, 2007.

• Vasconcelos, Andreia ; Cavaco-Paulo, Artur . Enzymatic removal of cellulose from cotton/polyester fabric blends. Cellulose (London) , v. 13, p. 611-618, 2006.

• Heumann, Sonja ; Eberl, Anita ; Pobeheim, Herbert ; Liebminger, Stefan ; Fischer-Colbrie, Gudrun ; Almansa, Eva ; Cavaco-Paulo, Artur ; Gübitz, Georg M. . New model substrates for enzymes hydrolysing polyethyleneterephthalate and polyamide fibres. Journal of Biochemical and Biophysical Methods , v. 69, p. 89-99, 2006.

• Silva, Carla J.S.M. ; Zhang, Qinghua ; Shen, Jinsong ; Cavaco-Paulo, Artur . Immobilization of proteases with a water soluble insoluble reversible polymer for treatment of wool. Enzyme and Microbial Technology , v. 39, p. 634-640, 2006.

• Matamá, Teresa ; Vaz, Filipe ; Gübitz, Georg M. ; Cavaco-Paulo, Artur . The effect of additives and mechanical agitation in surface modification of acrylic fibres by cutinase and esterase. Biotechnology Journal (Print) , v. 1, p. 842-849, 2006.

• Erlacher, A. ; Sousa, F. ; Schroeder, M. ; Jus, S. ; Kokol, V. ; Cavaco-Paulo, A. ; GUEBITZ, G. M. ; Cavaco-Paulo, Artur . A new cuticle scale hydrolysing protease from Beauveria brongniartii. Biotechnology Letters , v. 28, p. 703-710, 2006.

• Vasconcelos, Andreia ; Silva, Carla J. S. M. ; Schroeder, Marc ; Guebitz, Georg M. ; Cavaco-Paulo, Artur . Detergent Formulations for Wool Domestic Washings Containing Immobilized Enzymes. Biotechnology Letters , v. 28, p. 725-731, 2006.

• Schroeder, M. ; Heumann, S. ; Silva, C. J. S. M. ; Cavaco-Paulo, A. ; GUEBITZ, G. M. ; Cavaco-Paulo, Artur . Specificities of a chemically modified laccase from Trametes hirsuta on soluble and cellulose-bound substrates. Biotechnology Letters , v. 28, p. 741-747, 2006.

• Lenting, H. B. M. ; Schroeder, M. ; GUEBITZ, G. M. ; Cavaco-Paulo, A. ; Shen, J. ; Cavaco-Paulo, Artur . New Enzyme-based Process Direction to Prevent Wool Shrinking without Substantial Tensile Strength Loss. Biotechnology Letters , v. 28, p. 711-716, 2006.

• Schroeder, M. ; Lenting, H. B. M. ; Kandelbauer, A. ; Silva, C. J. S. M. ; Cavaco-Paulo, A. ; Gübitz, G. M. ; Cavaco-Paulo, Artur . Restricting detergent protease action to surface of protein fibres by chemical modification. Applied Microbiology and Biotechnology , v. 72, p. 738-744, 2006.

• Guebitz, Georg M. ; Buchert, Johanna ; Cavaco-Paulo, Artur ; Heine, Elisabeth . Advances in biotechnology for fibre processing. Biotechnology Letters , v. 28, p. 679-680, 2006.

• Fischer-Colbrie, Gudrun ; Herrmann, Melanie ; Heumann, Sonja ; Puolakka, Arja ; Wirth, Amina ; Cavaco-Paulo, Artur ; Guebitz, Georg M. . Surface modification of polyacrylonitrile with nitrile hydratase and amidase from. Biocatalysis and Biotransformation (Print) , v. 24, p. 419-425, 2006.

• Silva, Carla Manuela ; Carneiro, Filipa ; O'Neill, Alexandre ; Fonseca, Lu s P. ; Cabral, Joaquim S. M. ; Guebitz, Georg ; Cavaco-Paulo, Artur . Cutinase?A new tool for biomodification of synthetic fibers. Journal of Polymer Science. Part A, Polymer Chemistry , v. 43, p. 2448-2450, 2005.

• Silva, Carla J.S.M. ; Prabaharan, M. ; Gübitz, Georg ; Cavaco-Paulo, Artur . Treatment of wool fibres with subtilisin and subtilisin-PEG. Enzyme and Microbial Technology , v. 36, p. 917-922, 2005.

• Munteanu, Florentina-Daniela ; Ruiz-Dueñas, Francisco J. ; Mart nez, Angel T. ; Cavaco-Paulo, Artur . Kinetics of direct and substrate-mediated electron transfer of versatile peroxidase-modified graphite electrodes. Journal of Electroanalytical Chemistry (1992) , v. 580, p. 35-40, 2005.

• Ramalho, P. A. ; Cardoso, M. H. ; Cavaco-Paulo, Artur ; Ramalho, M. T. . Characterization of Azo Reduction Activity in a Novel Ascomycete Yeast Strain. Applied and Environmental Microbiology (Print) , v. 70, p. 2279-2288, 2004.

• Zille, A. ; Ramalho, P. ; TZANOV, T. ; Millward, R. ; Aires, V. ; Cardoso, M.H. ; Ramalho, M.T. ; Gubitz, G.M. ; Cavaco-Paulo, A. . Predicting Dye Biodegradation from Redox Potentials. Biotechnology Progress (Print) , v. 20, p. 1588-1592, 2004.

• . Enzymes in fibre processing. Biocatalysis and Biotransformation (Print) , v. 22, p. 297-297, 2004.

• Almansa, Eva ; Kandelbauer, Andreas ; Pereira, Luciana ; Cavaco-Paulo, Artur ; Guebitz, Georg M. . Influence of structure on dye degradation with laccase mediator systems. Biocatalysis and Biotransformation (Print) , v. 22, p. 315-324, 2004.

• Choe, Eun Kyung ; Nam, Chang Woo ; Kook, Sung Ryong ; Chung, Chinkap ; Cavaco-Paulo, Artur . Implementation of batchwise bioscouring of cotton knits. Biocatalysis and Biotransformation (Print) , v. 22, p. 375-382, 2004.

• Kandelbauer, Andreas ; Erlacher, Angelika ; Cavaco-Paulo, Artur ; Guebitz, Georg M. . Laccase-catalyzed decolorization of the synthetic azo-dye diamond black PV 200 and of some structurally related derivatives. Biocatalysis and Biotransformation (Print) , v. 22, p. 331-339, 2004.

• Fischer-Colbrie, Gudrun ; Heumann, Sonja ; Liebminger, Stefan ; Almansa, Eva ; Cavaco-Paulo, Artur ; Guebitz, Georg M. . New enzymes with potential for PET surface modification. Biocatalysis and Biotransformation (Print) , v. 22, p. 341-346, 2004.

• O'Neill, Alexandre ; Cavaco-Paulo, Artur . Monitoring biotransformations in polyesters. Biocatalysis and Biotransformation (Print) , v. 22, p. 353-356, 2004.

• Silva, Carla ; Cavaco-Paulo, Artur . Monitoring biotransformations in polyamide fibres. Biocatalysis and Biotransformation (Print) , v. 22, p. 357-360, 2004.

• Stamenova, Maria ; Tzanov, Tzanko ; Betcheva, Rossitza ; Cavaco-Paulo, Artur . Proteases to Improve the Mechanical Characteristics of Durable Press Finished Cotton Fabrics. Macromolecular Materials and Engineering (Print) , v. 288, p. 71-75, 2003.

• Tzanov, Tzanko ; Silva, Carla Joana ; Zille, Andrea ; Oliveira, Jovita ; Cavaco-Paulo, Artur . Effect of Some Process Parameters in Enzymatic Dyeing of Wool. Applied Biochemistry and Biotechnology , v. 111, p. 1-14, 2003.

• Zille, Andrea ; Tzanov, Tzanko ; Gübitz, Georg M. ; Cavaco-Paulo, Artur . IMMOBILIZED LACCASE FOR DECOLOURIZATION OF REACTIVE BLACK 5 DYEING EFFLUENT. Biotechnology Letters , v. 25, p. 1473-1477, 2003.

• Ryan, S ; Schnitzhofer, W ; Tzanov, T ; Cavaco-Paulo, A ; Gübitz, G.M ; Cavaco-Paulo, Artur . An acid-stable laccase from Sclerotium rolfsii with potential for wool dye decolourization. Enzyme and Microbial Technology , v. 33, p. 766-774, 2003.

• Tzanov, Tzanko ; Basto, Carlos ; Gübitz, Georg M. ; Cavaco-Paulo, Artur . Laccases to Improve the Whiteness in a Conventional Bleaching of Cotton. Macromolecular Materials and Engineering (Print) , v. 288, p. 807-810, 2003.

• Tzanov, Tzanko ; Andreaus, Jürgen ; Guebitz, Georg ; Cavaco-Paulo, Artur . Protein interactions in enzymatic processes in textiles. Electronic Journal of Biotechnology , v. 6, p. 146-154, 2003.

• Gübitz, Georg M ; Paulo, Artur Cavaco ; Cavaco-Paulo, Artur . New substrates for reliable enzymes: enzymatic modification of polymers. Current Opinion in Biotechnology , v. 14, p. 577-582, 2003.

• Heikinheimo, Lea ; Miettinen-Oinonen, Arja ; Cavaco-Paulo, Artur ; Buchert, Johanna . Effect of purifiedTrichoderma reesei cellulases on formation of cotton powder from cotton fabric. Journal of Applied Polymer Science (Print) , v. 90, p. 1917-1922, 2003.

• ANDREAUS, J. ; RAMOS, L. P. ; Cavaco-Paulo, Artur . DRY ACTION OF TRICHODERMA REESEI CELLULASES ON COTTON FABRICS. Journal Of The Society Of Dyers And Colourists, v. 116, p. 121-125, 2000.

• CAMPOS, R. ; ANDREAUS, J. ; GÜBITZ, G. ; Cavaco-Paulo, Artur . STUDY ON INDIGO-CELLULASE INTERACTIONS. Textile Research Journal, 2000.

• Cavaco-Paulo, Artur ; GÜBITZ, G. ; ABADULLA, E. ; SILVA, L. ; ROBRA, K. H. . ENZYMATIC DECOLORIZATION OF TEXTILE DYEING EFFLUENTS. Textile Research Journal, 2000.

• TAUBER, M. ; Cavaco-Paulo, Artur ; ROBRA, K. H. ; GÜBITZ, G. . NITRILE HYDRATASE AND AMIDASE FROM RHODOCOCCUS RHODOCHROUS HYDROLYSE ACRYLIC FIBERS AND GRANULATES. Enzyme and Microbial Technology , 2000.

• ANDREAUS, J. ; CAMPOS, R. ; Cavaco-Paulo, Artur . INFLUENCE OF CELLULASES ON INDIGO BACKSTAINING. Textile Research Journal, 2000.

• MORGADO, J. ; Cavaco-Paulo, Artur ; ROUSELLE, M. . ENZYMATIC TREATMENT OF LYOCELL - CLARIFICTION OF DEPILLING MECHANISMS. Textile Research Journal, 2000.

• CARNEIRO, A. ; ABREU, A. ; EVTUGUIN, D. ; C NETO, ; GÜBITZ, G. ; Cavaco-Paulo, Artur . POLYOXOMETALATES AS PROMOTERS OF LACCASE -ASSISTED REACTIONS. Journal of Molecular Catalysis. B, Enzymatic , v. 9, p. 293-295, 2000.

• AZEVEDO, H. ; BISHOP, D. ; Cavaco-Paulo, Artur . EFFECTS OF AGITATION LEVEL ON THE ADSORPTION, DESORPTION AND ACTIVITIES ON COTTON FABRICS OF FULL LENGTH AND CORE DOMAINS OF EGV (H. INSOLENS) AND CENA (C. FIMI). Enzyme and Microbial Technology , 2000.

• TZANOV, T. ; COSTA, S. ; GÜBITZ, G. ; Cavaco-Paulo, Artur . DYEING WITH CATALASE TREATED BLEACHING BATHS. Journal Of The Society Of Dyers And Colourists, 2000.

• Cavaco-Paulo, Artur ; MORGADO, J. ; ANDREAUS, J. ; KILBURN, D. . INTERACTIONS OF COTTON WITH CBD PEPTIDES. Enzyme and Microbial Technology , v. 25, p. 639-643, 1999.

• ANDREAUS, J. ; AZEVEDO, H. ; Cavaco-Paulo, Artur . EFFECTS OF TEMPERATURE ON THE CELLULOSE BINDING ABILITY OF CELLULASE ENZYMES. Journal of Molecular Catalysis. B, Enzymatic , v. 7, p. 233-239, 1999.

• BARCELLOS, I. O. ; MORGADO, J. ; Cavaco-Paulo, Artur . TRATAMENTO ENZIMÁTICO ANTES OU APÓS O TINGIMENTO. Química Têxtil, v. Junho, p. 75-76, 1999.

• Cavaco-Paulo, Artur ; ALMEIDA, L. ; BISHOP, D. . HYDROLYSIS OF COTTON CELLULOSE BY ENGINEERED CELLULASES FROM TRICHODERMA REESEI. Textile Research Journal, v. 4, p. 273-280, 1998.

• OIJUSLUOMA, L. ; Cavaco-Paulo, Artur ; NOUSIAINEN, P. ; SIIKA-AHO, M. ; BUCHERT, J. . TREATMENT OF COTTON FABRICS WITH PURIFIED TRICHODERMA REESEI CELLULASES. Journal Of The Society Of Dyers And Coulorists, v. 114, p. 216-220, 1998.

• Cavaco-Paulo, Artur ; MORGADO, J. ; ALMEIDA, L. ; KILBURN, D. . INDIGO BACKSTAINING DURING CELLULASE WASHING. Textile Research Journal, v. 6, p. 398-401, 1998.

• Cavaco-Paulo, Artur . MECHANISM OF CELLULASE ACTION IN TEXTILE PROCESS. Carbohydrate Polymers , v. 4, p. 423-428, 1998.

• Cavaco-Paulo, Artur ; HES, L. ; PINHEIRO, F. ; GONÇALVES, M. . THE EFFECT OF SELECTED MECHANICAL PROPERTIES ACQUIRED BY KES-F INSTRUMENTS ON THE LEVEL OF PUCKERING OF COTTON FABRICS AFTER WASHING. International Journal Of Clothing Science Technology, v. 9, p. 188-192, 1997.

• Cavaco-Paulo, Artur ; ALMEIDA, L. ; CORTEZ, J. . THE EFFECT OF CELLULASE TREATMENT IN TEXTILE WASHING PROCESSES. Journal Of The Society Of Dyers And Colourists, v. 113, p. 218-222, 1997.

• Cavaco-Paulo, Artur ; RIOS, M. J. . MECHANICAL PROPERTIES OF CELLULASE TREATED FABRICS ANALYZED. American Dyestuff Reporter, v. 9, p. 20-28, 1997.

• Cavaco-Paulo, Artur ; ALMEIDA, L. . KINETIC PARAMETERS MEASURED DURING CELLULASE PROCESSING OF COTTON. Textile Research Journal, v. 87, p. 227-233, 1996.

• Cavaco-Paulo, Artur ; ALMEIDA, L. ; BISHOP, D. . EFFECTS OF AGITATION AND ENDOGLUCANASE PRETREATMENT ON THE HYDROLYSIS OF COTTON FABRICS BY A TOTAL CELLULASE. Textile Research Journal, v. 88, n.287, p. 287-294, 1996.

• Cavaco-Paulo, Artur ; ALMEIDA, L. ; BISHOP, D. . CELLULASE ACTIVITIES AND FINISHING EFFECTS. Textile Chemist Colorist, p. 28-32, 1996.

• Cavaco-Paulo, Artur ; ALMEIDA, L. . CELLULASE HYDROLYSIS OF COTTON CELLULOSE: THE EFFECTS OF MECHANICAL ACTION, ENZYME CONCENTRATION AND DYED SUBSTRATES. Biocatalysis, v. 10, p. 353-360, 1994.

• Cavaco-Paulo, Artur ; ALMEIDA, L. . APLICAÇÕES DE TECNOLOGIAS ENZIMÁTICAS NO ACABAMENTO DO ALGODÃO. Nova Têxtil, p. 34-37, 1994.

• Cavaco-Paulo, Artur ; ALMEIDA, L. . SOFTENING OF COTTON BY ENZYMATIC HYDROLYSIS. Melliand Textilberichte, v. 74, p. 404-407, 1993.

• Cavaco-Paulo, Artur . AVALIAÇÃO OBJECTIVA DO TOQUE DE TECIDOS. Textilia, v. 8, p. 22-27, 1993.

• Cavaco-Paulo, Artur ; ALMEIDA, L. . A HIDRÓLISE ENZIMÁTICA DO ALGODÃO -NOVA TÉCNICA DE AMACIAMENTO. Nova Têxtil, p. 52-57, 1991.

• V. Nierstrasz ; Cavaco-Paulo, Artur . ADVANCES IN TEXTILE BIOTECHNOLOGY. UK: Woodhead Publishing Limieted, 2010.

• Cavaco-Paulo, Artur ; ERIKKSON, E. K. . ENZYME APPLICATIONS FOR FIBER PROCESSING. ACS Symposium Series Book, 1998. 340p .

• C. Silva ; Cavaco-Paulo, Artur ; V. Nierstrasz . ENZYMATIC HYDROLYSIS AND MODIFICATION OF CORE POLYMER FIBRES FOR TEXTILE AND OTHER APPLICATIONS. Advances in textile biotechnology. 107ed.: Oxford ; Philadelphia : Woodhead Pub. [in association with] The Textile Institute, 2010, v. , p. -.

• T. Matamá ; Cavaco-Paulo, Artur . ENZYMATIC MODIFICATION OF POLYACRYLONITRILE AND CELLULOSE ACETATE FIBRES FOR TEXTILE AND OTHER APPLICATIONS. Advances in textile biotechnology. 107ed.: Oxford ; Philadelphia : Woodhead Pub. [in association with] The Textile Institute, 2010., 2010, v. , p. 98-131.

• C. Silva ; T. Matamá ; Cavaco-Paulo, Artur . BIOTRANSFORMATION OF SYNTHETIC FIBERS. Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology. : M. C. Flickinger (editor), 2010, v. , p. -.

• Munteanu, Florentina-Daniela ; Nicolae Dinca ; Cavaco-Paulo, Artur . MALDI-TOF Mass Spectrometry in Textile Industry. Applications of Mass Spectrometry in Life Safety. : Springer, 2008, v. , p. 193-203.

• Cavaco-Paulo, Artur ; ALMEIDA, L. ; BISHOP, D. . THE TREATMENT OF COTTON CELLULOSE WITH TRICHODERMA REESEI ENGINEERED CELLULASES. In: Williams P.A.; Kennedy J.F.. (Org.). The Chemistry and Processing of Wood and Plant Fibrous Materials. : Woodhead-Cambridge, 1996, v. , p. 227-234.

Outras produções

Projetos de pesquisa

• 2012 - 2014

  NOVO - Novel approaches for prevention and degeneration of pathogenic bacteria biofilms formed on medical devices e.g. catheters - FP7- 278402, Descrição: Biofilms are bacterial communities encased in a self-produced hydrated polymeric matrix. An important characteristic of microbial biofilms is their innate resistance to the immune system and susceptibility to antibiotics. This resistance has made microbial biofilms a common cause of medical infections, and difficult-to-treat infections caused by colonized foreign bodies. The NOVO project aims at developing novel approaches to prevent and/or degrade biofilms on catheters elongating their usage in humans up to 10 days. Two complementary approaches for biofilm prophylaxis will be developed: A. Ultrasonic coating of Inorganic antibiofouling agents (process developed by partner BIU) based on a single step sonochemical process to: a) Produce metal fluorides or metal oxides (e.g. MgF2, ZnO) nanoparticles (NPs) and simultaneously b) Impregnate them as antibacterial factors on the catheters. c) Co-coating with bio-inert polymer layers (containing highly hydrophilic antifouling polyethylene glycol, zwitterionic moieties or sugar-groups) grafted onto NPs of adjusted size to the size of MgF2/ZnO NPs or directly onto MgF2/ZnO NPs; to form a hydrogel layer for the protection of the MgF2/ZnO antibiofouling activity. B. Bio/organic antibiofouling activation: 1) Novel coating for catheters based on radical catalyzed polymers to yield anti-bacterial activity. An enzymatic reaction will be applied on the phenolic compounds to generate phenolic radicals to be further polymerized on the catheter surface as an antibiofilm agent. 2) Develop and engineer Cellobiose Dehydrogenases (CDH) that actively oxidizes and degrades biofilms polysaccharides concomitantly producing stoichiometrically H2O2 as antibacterial agent. The enzymes will be coated on the catheters via a lubricant or by the Ultrasonic (US) process after their immobilization. Some novel CDH representatives already show very low activity on glucose which should be removed by further genetic engineering.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Artur Manuel Cavaco Paulo - Coordenador.

• 2010 - 2012

  COTTONBLEACH - Improved Novel Eco-Friendly Bleaching System for Cotton Using Enzyme and Ultrasound Processes - FP7 243529, Descrição: Cotton textiles --the main natural-fiber textile used worldwide-- undergo a toxic and costly bleaching process that weighs heavily on the quality, cost and environmental impact of textile manufacture. CottonBleach proposes the development of an improved cotton bleaching technology, more respectful with the textiles and the environment, to improve the competitive edge of European textile SMEs. Current bleaching methods use hydrogen peroxide (H2O2) and sodium hypochlorite (NaClO, aka bleach), resulting in fabric damage, formation of toxic by-products and large amounts of water and energy to remove these chemicals. The proposed CottonBleach technology offers a non-toxic Totally Chlorine Free (TCF) bleaching technology using a combination of sequential enzymatic techniques enhanced through the use of ultrasound technology. This innovative technology will maintain the natural strength of the cotton fiber, providing significantly improved bleaching effectiveness with minimal fiber damage. The scientific objective of CottonBleach is to further investigate the use of ultrasound-enhanced enzymatic bleaching on an industrial scale of development, as manifested by recently published economic analysis which consider the use of enzymes as cost effective for textile mills to adopt. This proposal also fulfils the objectives of FP7 collective research in that it will expand the knowledge base of large communities of SMEs and develop innovative technology that has potential applications in the broader bleaching industry. . , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Artur Manuel Cavaco Paulo - Coordenador.

• 2009 - 2013

  NANOFOL Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases. SEVENTH FRAMEWORK PROGRAMME THEME [NMP] [FP7-NMP-2008-LARGE-2 (FP7 NMP-2008-4.0-1)], Descrição: NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: Design , development and production of nanobiodevices (FBN) targeting directly effector cells Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages Design of models that will enable to minimize animal experimentation. Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Artur Manuel Cavaco Paulo - Coordenador.

• 2006 - 2010

  Biorenew White Biotechnology for added value products from renewable plant polymers: Design of tailor-made biocatalysts and new Industrial bioprocesses. SIXTH FRAMEWORK PROGRAMME NMP2-CT-2006-026456, Descrição: Plant polymers are the main source of renewable materials in Earth. The use of biotechnology will permit to develop new routes for cellulose and lignin-based added value products, including speciality paper products and surfactants. The industrial utilization of cellulose includes pulps for the paper industry. However, its characteristics permits to use cellulose for speciality products whose potential is still to be fully investigated. Lignin is a heterogeneous aromatic polymer, highly recalcitrant towards degradation. Most industrial uses of cellulose require the previous removal of lignin, which is generally burnt at the mill. However, the chemical nature of lignin makes this polymer an interesting source of aromatic chemicals. Oxidoreductases are involved in both lignin biosynthesis and biodegradation. Therefore, they have the highest potential for modification of lignocellulosic materials and isolated lignins. However, the natural enzymes are far to optimally operate under industrial conditions. Some oxidoreductases have been extensively investigated in terms of structure-function relationships. This will allow a new approach based on tuning their catalytic and operational properties using protein-engineering tools, such as forced evolution, and site-directed mutagenesis. The applications of tailor-made enzymes will include among others: i) increase of strength and other properties of cellulose fibres, and improve refining; ii) production of lignin-free cellulose for high-quality products; iii) production of lignin-based surfactants (as dispersants and nano-emulsifiers) and adhesives. In this way, the IP will contribute to maintain the EU leading position in the market of industrial biotechnology. The potential impact is illustrated by the turnover of the EU Paper-Forest cluster that attains 400 000 million/year. In this way, the IP will contribute to transform a part of the EU chemical sector to more sustainable and eco-friendly manufacturing proce. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Artur Manuel Cavaco Paulo - Coordenador.

• 2006 - 2010

  Lidwine Multifunctional Medical Textiles for wound (e.g. Decubitus) prevention and improved wound healing. SIXTH FRAMEWORK PROGRAMME NMP2-CT-2006-026741, Descrição: The project focuses on the development of multifunctional medical textiles to prevent wounds (such as Decubitus) on one hand and stimulate wound healing on the other hand. Three different approaches will be followed: 1. blood circulation stimulation: a textile-based massage cuff will be realized in which electric field sensitive contractive polymers are integrated. Alternatively electro-pulsed muscle stimulation will be realized by a textile integrated electrodes-circuits. 2. reduction of skin-textile friction: nano-coatings will be developed with this property based on brush-nanocoatings. 3. development of anti-bacterial textiles with controlled moisture management. Basic anti-bacterial properties will be realized by application of specific biopolymers and functionalized nanoparticles produced and applied by ultrasound. Additionally controlled (both initiation and rate of release) drug release will be developed in which the release will be controlled by an enzymatic switch. In this approach integration of the different systems developed will be an important issue for optimal performance. All products from the 3 approaches will be technically validated and evaluated in practise (hospitals). This project will contribute now, and in the future where people become older, to a substantial reduction in the medical cost by reduction of recovery days and by prevention (beyond 40 billion Euro/annum in Europe).. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Artur Manuel Cavaco Paulo - Coordenador.

• 2005 - 2009

  Bioseal - Development of biotechnology derived alternatives for sustainable detergents and innovative strategies of using sustainable ingredients by encapsulation and surfactant structuring. SIXTH FRAMEWORK PROGRAMME - Marie Curie Early Stage Researcher, Descrição: The Protect and Gamble European Technical Centre (B) and its partners offer the opportunity to 7 fellows to build up scientific-technological knowledge in the field of enzyme technology and encapsulation/surfactant structuring technology in order to develop sustainable detergents that will lead to significant reductions of detergent weight, energy, CO2 and solid waste. The training focuses on developing the scientific basis to create a detergent, which minimizes surfactant and bulk bleach level needs and rep laces it with different types of enzymes, biopolymers and biosurfactants.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Artur Manuel Cavaco Paulo - Coordenador.

• 2004 - 2006

  Ultratec Acceleration of textile processes by ultrasound technology., Descrição: The project objective is supporting long-term innovation of the European textile industry and increasing its competitiveness by means of the generation of relevant scientific knowledge to develop novel ultrasound processes for textile andnonwoven applications.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Artur Manuel Cavaco Paulo - Coordenador.

• 2002 - 2005

  Protex Modified proteases for the reduction of felting and shrinkage of wool textiles. EC Fifth Framework Programme, Descrição: The market value of wool is limited by the fact that consumers place increasingly high demands on machine wash ability and soft handle. Felting, which is a typical property of wool due to the configuration of the scales of the wool fibre, is a serious problem, especially during washing. Chlorination, followed by polymer deposition, is commonly used to confer shrink-resistance, but this involves major drawbacks with respect to chlorine and the environment. The main aspect of this proposal is to develop a novel enzymatic process for producing machine washable wool by limiting the enzymatic degradation of wool fibres to their cuticle scales. The novel engineered enzymes will be developed to achieve this goal. The radically new bioprocessing regimes for wool scouring and finishing processes, and commercial products will be developed. This would be a major technological breakthrough to completely replace a hazardous chemical preparation and finishing route. . , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Artur Manuel Cavaco Paulo - Coordenador.

• 2001 - 2005

  Biosyntex Biotechnical quality improvement of synthetic textile fibres, Descrição: The modification of synthetic fibres in order to obtain the desired end-product properties requires high amounts of energy and chemicals, which are partially discharged to the environment and are released from the end-products causing serious health risks. BioSynTex will develop new enzyme systems for the targeted modification of polyester (PET), polyacrylonitrile (PAN) and polyamide (PA/Ar) fibres. The obtained quality improving functionalities on the fibre surface will be characterised in detail. Eco-efficient finishing processes using the enzymatically modified fibres will be investigated in laboratory sale and larger scale using typical machinery. Savings of up to 30 % dye, 55 % energy and 20 % water during dyeing of textiles (clothing) and 45 % coupling agents during coating of PET (for tarpaulins) and 30 % of binders during the production of awning fabrics (from PAN) can be expected based on the new fibre functionalities.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Artur Manuel Cavaco Paulo - Coordenador.

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