Philippe Grellier

Possui doutorado em Bioquímica pela Universidade de Poitiers (1990). , atuando principalmente nos seguintes temas: plamodio e trypanosoma. Actual position: Professor at the National Museum of Natural History (MNHN), Associate Director of Department RDDM of MNHN, and Head of the team ?Adaptation of Protozoan to their Environment? (16 persons) of the UMR 5289 CNRS/MNHN and in charge of the MNHN Master. The general thematic of my group deals with the adaptation processes, both at the molecular and cellular level, of protozoa, free or parasitic, to their environment with the following objectives: the understanding of the mechanisms controlling the development of protozoa by identifying the key molecules and their regulation. In addition to the therapeutic interest that can emerge for the parasites, the identification of key molecules involved in vital processes allows the search for orthologs in other organisms, and therefore the comprehension and the comparison of their biological roles in organisms that are phylogenetically more or less close, illustrating thereby different evolutionary contexts. The acquisition of post-genomic analysis methodologies during the last years (transcriptomic, proteomic, inverse genetics...) allows us to propose an integrative approach at the interface between chemistry and biology, from the comprehension of the adaptative processes via the definition of their molecular basis to the functional analysis of the genes of interest and of their products. Our main models are the parasitic protozoa Plasmodium, belonging to the family of the Apicomlexa and responsible for malaria, and Trypanosoma, belonging to the Kinetoplastida and responsible for sleeping sickness and Chagas? disease. Other Apicomplexa, such as Gregarina as well as free ciliates are studied as well. Main research interests: - Molecular and evolutionary aspects of parasitic morphogenesis and differentiation, with a focus on Plasmodium falciparum, Trypanosoma brucei and Trypanosoma cruzi. - Definition of new chemotherapeutic targets and synthesis of specific inhibitors. - Research of new anti-parasite drugs or substances reversing parasite resistance derived from traditional medicine (ethnopharmcology, natural products). - Molecular cross-talk between bacteria and protozoa: intestinal bacteria?Giardia, cyanobacteria-ciliates.

Informações coletadas do Lattes em 10/11/2022

Acadêmico

Formação acadêmica

Doutorado em Bioquímica

1986 - 1990

Universidade de Poitiers
Título: Differentiation of P. falciparum merozoites and the reinvation phase of erytrocytes
Orientador: J Schrevel
Palavras-chave: Plamodio.Grande área: Ciências BiológicasSetores de atividade: Saúde Humana.

Orientou

Carlos García

Investigação da exflagelação de Plasmodium berghei utilizando ferramentas proteomicas; 2017; Tese (Doutorado em Patologia Molecular) - Universidade de Brasília,; Coorientador: Philippe Grellier;

Produções bibliográficas

SORRES, JONATHAN ; HEBRA, TÉO ; ELIE, NICOLAS ; LEMAN-LOUBIÈRE, CHARLOTTE ; GRAYFER, TATYANA ; Grellier, Philippe ; TOUBOUL, DAVID ; STIEN, DIDIER ; Eparvier, Véronique . Antiparasitic Ovalicin Derivatives from Pseudallescheria boydii, a Mutualistic Fungus of French Guiana Termites. MOLECULES , v. 27, p. 1182, 2022.
GARCIA, CARLOS HENRIQUE SARAIVA ; Depoix, Delphine ; CARVALHO, PAULO COSTA ; BASTOS, IZABELA MARQUES DOURADO ; RICART, CARLOS ANDRÉ ORNELAS ; DE SOUSA, MARCELO VALLE ; FERGUSON, DAVID J.P. ; SANTANA, JAIME MARTINS ; Grellier, Philippe ; Charneau, Sébastien . Comparative proteomic analysis of kinesin-8B deficient Plasmodium berghei during gametogenesis. Journal of Proteomics , v. 236, p. 104118, 2021.
DE OLIVEIRA, LUCAS SILVA ; ALBORGHETTI, MARCOS RODRIGO ; CARNEIRO, RENATA GARCIA ; BASTOS, IZABELA MARQUES DOURADO ; AMINO, ROGERIO ; Grellier, Philippe ; Charneau, Sébastien . Calcium in the Backstage of Malaria Parasite Biology. Frontiers in Cellular and Infection Microbiology , v. 11, p. 1, 2021.
DACHEUX, MÉLANIE ; CHAOUCH, SORAYA ; JOY, ALONSO ; LABAT, AMANDINE ; PAYRÉ, CHRISTINE ; PETIT-PAITEL, AGNÈS ; BIHL, FRANCK ; LAGRANGE, ISABELLE ; Grellier, Philippe ; TOUQUI, LHOUSSEINE ; LAMBEAU, GÉRARD ; DEREGNAUCOURT, CHRISTIANE . Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model. BIOCHIMIE , v. 189, p. 120-136, 2021.
OTOGO N?NANG, ELVIS ; LE POGAM, PIERRE ; NDONG MBA, THIERY ; SIMA OBIANG, CÉDRIC ; Mouray, Elisabeth ; Grellier, Philippe ; KUMULUNGUI, BRICE ; CHAMPY, PIERRE ; Beniddir, Mehdi A. . Targeted Isolation of Hemitheion from , a Proposed Biosynthetic Intermediate of Theionbrunonines. JOURNAL OF NATURAL PRODUCTS , v. 84, p. 1409-1413, 2021.
Depoix, Delphine ; MARQUES, SARA RUTE ; FERGUSON, DAVID JP ; CHAOUCH, SORAYA ; DUGUET, THOMAS ; SINDEN, ROBERT E ; Grellier, Philippe ; KOHL, LINDA . Vital role for Kinesin8B in axoneme assembly during male gamete formation and mosquito transmission. CELLULAR MICROBIOLOGY , v. 22, p. 1, 2020.
DUVAL, ROMAIN ; COTTET, KEVIN ; BLAUD, MAGALI ; MERCKX, ANAÏS ; HOUZÉ, SANDRINE ; Grellier, Philippe ; Lallemand, Marie-Christine ; MICHEL, SYLVIE . A Photoalkylative Fluorogenic Probe of Guttiferone A for Live Cell Imaging and Proteome Labeling in Plasmodium falciparum. MOLECULES , v. 25, p. 5139, 2020.
PEPE, DIONISSIA A. ; TOUMPA, DIMITRA ; ANDRÉ-BARRÈS, CHRISTIANE ; MENENDEZ, CHRISTOPHE ; Mouray, Elisabeth ; BALTAS, MICHEL ; Grellier, Philippe ; PAPAIOANNOU, DIONISSIOS ; ATHANASSOPOULOS, CONSTANTINOS M. . Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity. ACS Medicinal Chemistry Letters , v. 11, p. 921-927, 2020.
PALLA, DESPINA ; ANTONIOU, ANTONIA I. ; BALTAS, MICHEL ; MENENDEZ, CHRISTOPHE ; Grellier, Philippe ; Mouray, Elisabeth ; ATHANASSOPOULOS, CONSTANTINOS M. . Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline. MOLECULES , v. 25, p. 4858, 2020.
N'TAMON, AMON DIANE ; OKPEKON, ABOUA TIMOTHÉE ; BONY, NICAISE F. ; BERNADAT, GUILLAUME ; GALLARD, JEAN-FRANÇOIS ; KOUAMÉ, TAPÉ ; SÉON-MÉNIEL, BLANDINE ; Leblanc, Karine ; RHARRABTI, SOMIA ; Mouray, Elisabeth ; Grellier, Philippe ; AKE, MICHÈLE ; AMIN, N'CHO CHRISTOPHE ; CHAMPY, PIERRE ; Beniddir, Mehdi A. ; LE POGAM, PIERRE . Streamlined targeting of Amaryllidaceae alkaloids from the bulbs of Crinum scillifolium using spectrometric and taxonomically-informed scoring metabolite annotations. PHYTOCHEMISTRY , v. 179, p. 112485, 2020.
BOUCINHA, CAROLINA ; CAETANO, AMANDA R ; SANTOS, HELENA LC ; HELAERS, RAPHAEL ; VIKKULA, MIIKKA ; BRANQUINHA, MARTA HELENA ; DOS SANTOS, ANDRÉ LUIS SOUZA ; Grellier, Philippe ; MORELLI, KARINA ALESSANDRA ; D'AVILA-LEVY, CLAUDIA MASINI . Analysing ambiguities in trypanosomatids taxonomy by barcoding. Memórias do Instituto Oswaldo Cruz , v. 115, p. 1, 2020.
KOUAMÉ, TAPÉ ; OKPEKON, ABOUA TIMOTHÉE ; BONY, NICAISE F. ; N?TAMON, AMON DIANE ; GALLARD, JEAN-FRANÇOIS ; RHARRABTI, SOMIA ; Leblanc, Karine ; Mouray, Elisabeth ; Grellier, Philippe ; CHAMPY, PIERRE ; Beniddir, Mehdi A. ; LE POGAM, PIERRE . Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras. MOLECULES , v. 25, p. 2654, 2020.
SOW, CISSÉ ; LAUGHHUNN, ANDREW ; GIRARD, YVETTE A. ; LANTERI, MARION C. ; AMAR EL DUSOUQUI, SORAYA ; STASSINOPOULOS, ADONIS ; Grellier, Philippe . Inactivation of in whole blood using the amustaline and glutathione pathogen reduction technology. TRANSFUSION , v. 60, p. 799-805, 2020.
ALCOVER, CHARLOTTE FOX ; BERNADAT, GUILLAUME ; KABRAN, FAUSTIN A. ; LE POGAM, PIERRE ; Leblanc, Karine ; FOX RAMOS, ALEXANDER E. ; GALLARD, JEAN-FRANÇOIS ; Mouray, Elisabeth ; Grellier, Philippe ; Poupon, Erwan ; Beniddir, Mehdi A. . Molecular Networking Reveals Serpentinine-Related Bisindole Alkaloids from , a Previously Well-Investigated Species. JOURNAL OF NATURAL PRODUCTS , v. 83, p. 1207-1216, 2020.
D?AVILA-LEVY, CLAUDIA M. ; BEARZATTO, BERTRAND ; AMBROISE, JÉRÔME ; HELAERS, RAPHAËL ; BUTENKO, ANZHELIKA ; YURCHENKO, VYACHESLAV ; A. MORELLI, KARINA ; L. C. SANTOS, HELENA ; BROUILLARD, PASCAL ; Grellier, Philippe ; GALA, JEAN-LUC ; VIKKULA, MIIKKA . First Draft Genome of the Trypanosomatid Herpetomonas muscarum ingenoplastis through MinION Oxford Nanopore Technology and Illumina Sequencing. Tropical Medicine And Infectious Disease , v. 5, p. 25, 2020.
NGUYEN, VAN-KIEU ; GENTA-JOUVE, GRÉGORY ; DUONG, THUC-HUY ; Beniddir, Mehdi A. ; GALLARD, JEAN-FRANÇOIS ; FERRON, SOLENN ; BOUSTIE, JOËL ; Mouray, Elisabeth ; Grellier, Philippe ; CHAVASIRI, WARINTHORN ; LE POGAM, PIERRE . Eumitrins C-E: Structurally diverse xanthone dimers from the vietnamese lichen Usnea baileyi. FITOTERAPIA , v. 141, p. 104449, 2020.
LASSE, CAMILA ; AZEVEDO, CLÊNIA S. ; DE ARAÚJO, CARLA N. ; MOTTA, FLÁVIA N. ; ANDRADE, MILENE A. ; ROCHA, AMANDA PEREIRA ; SAMPAIO, IRACYARA ; Charneau, Sébastien ; GÈZE, MARC ; Grellier, Philippe ; Santana, Jaime M. ; BASTOS, IZABELA M. D. . Prolyl Oligopeptidase From Leishmania infantum: Biochemical Characterization and Involvement in Macrophage Infection. Frontiers in Microbiology , v. 11, p. 1, 2020.
Motta, Flávia Nader ; AZEVEDO, CLÊNIA DOS SANTOS ; NEVES, BEATRIZ PEREIRA ; NUNES DE ARAÚJO, CARLA ; Grellier, Philippe ; MARTINS DE SANTANA, JAIME ; DOURADO BASTOS, IZABELA MARQUES . Oligopeptidase B, a missing enzyme in mammals and a potential drug target for trypanosomatid diseases. BIOCHIMIE , v. x, p. 1, 2019.
DACHEUX, MÉLANIE ; Sinou, Véronique ; PAYRÉ, CHRISTINE ; JEAMMET, LOUISE ; Parzy, Daniel ; Grellier, Philippe ; DEREGNAUCOURT, CHRISTIANE ; LAMBEAU, GÉRARD . Antimalarial Activity of Human Group IIA Secreted Phospholipase A in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins. INFECTION AND IMMUNITY , v. 87, p. 1, 2019.
MAROZIEN', AUDRON' ; LESANAVI ; DAVIOUD-CHARVET, ELISABETH ; Aliverti, Alessandro ; Grellier, Philippe ; ?ARLAUSKAS, JONAS ; . Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase. MOLECULES , v. 24, p. 4509, 2019.
TERZIC, VIDA ; POUSSE, GUILLAUME ; MÉALLET-RENAULT, RACHEL ; Grellier, Philippe ; Dubois, Joëlle . Dibenzocyclooctynes: Effect of Aryl Substitution on Their Reactivity toward Strain-Promoted Alkyne-Azide Cycloaddition. JOURNAL OF ORGANIC CHEMISTRY , v. 84, p. 8542-8551, 2019.
HOLOTA, SERHII ; KRYSHCHYSHYN, ANNA ; DERKACH, HALYNA ; TRUFIN, YAROSLAVA ; DEMCHUK, INNA ; GZELLA, ANDRZEJ ; Grellier, Philippe ; LESYK, ROMAN . Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity. BIOORGANIC CHEMISTRY , v. 86, p. 126-136, 2019.
ALLAIN, THIBAULT ; CHAOUCH, SORAYA ; THOMAS, MYRIAM ; TRAVERS, MARIE-AGNÈS ; VALLE, ISABELLE ; LANGELLA, PHILIPPE ; Grellier, Philippe ; POLACK, BRUNO ; Florent, Isabelle ; BERMÚDEZ-HUMARÁN, LUIS G. . Bile Salt Hydrolase Activities: A Novel Target to Screen Anti-Giardia Lactobacilli?. Frontiers in Microbiology , v. 9, p. 1, 2018.
ALLAIN, THIBAULT ; CHAOUCH, SORAYA ; THOMAS, MYRIAM ; VALLÉE, ISABELLE ; BURET, ANDRÉ G. ; LANGELLA, PHILIPPE ; Grellier, Philippe ; POLACK, BRUNO ; BERMÚDEZ-HUMARÁN, LUIS G. ; Florent, Isabelle . Bile-Salt-Hydrolases from the Probiotic Strain Lactobacillus johnsonii La1 Mediate Anti-giardial Activity in Vitro and in Vivo. Frontiers in Microbiology , v. 8, p. 1, 2018.
GARCIA, CARLOS H.S. ; Depoix, Delphine ; QUEIROZ, RAYNER M.L. ; SOUZA, JAQUES M.F. ; FONTES, WAGNER ; DE SOUSA, MARCELO V. ; SANTOS, MARLON D.M. ; CARVALHO, PAULO C. ; Grellier, Philippe ; Charneau, Sébastien . Dynamic molecular events associated to Plasmodium berghei gametogenesis through proteomic approach. Journal of Proteomics , v. 180, p. 88-98, 2018.
KRYSHCHYSHYN, ANNA ; KAMINSKYY, DANYLO ; NEKTEGAYEV, IGOR ; Grellier, Philippe ; LESYK, ROMAN . Isothiochromenothiazoles-A Class of Fused Thiazolidinone Derivatives with Established Anticancer Activity That Inhibits Growth of Trypanosoma brucei brucei. Scientia Pharmaceutica , v. 86, p. 47, 2018.
OTOGO N?NANG, ELVIS ; BERNADAT, GUILLAUME ; Mouray, Elisabeth ; KUMULUNGUI, BRICE ; Grellier, Philippe ; Poupon, Erwan ; CHAMPY, PIERRE ; Beniddir, Mehdi A. . Theionbrunonines A and B: Dimeric Vobasine Alkaloids Tethered by a Thioether Bridge from. ORGANIC LETTERS , v. 20, p. 6596-6600, 2018.
AZEVEDO, CLÊNIA S. ; GUIDO, BRUNA C. ; PEREIRA, JHONATA L. ; NOLASCO, DIEGO O. ; CORRÊA, RAFAEL ; MAGALHÃES, KELLY G. ; MOTTA, FLÁVIA N. ; Santana, Jaime M. ; Grellier, Philippe ; BASTOS, IZABELA M. D. . Revealing a Novel Otubain-Like Enzyme from Leishmania infantum with Deubiquitinating Activity toward K48-Linked Substrate. FRONTIERS IN CHEMISTRY , v. 5, p. eCollection 201, 2017.
FOX RAMOS, ALEXANDER E. ; ALCOVER, CHARLOTTE ; EVANNO, LAURENT ; Maciuk, Alexandre ; Litaudon, Marc ; DUPLAIS, CHRISTOPHE ; BERNADAT, GUILLAUME ; GALLARD, JEAN-FRANÇOIS ; Jullian, Jean-Christophe ; Mouray, Elisabeth ; Grellier, Philippe ; Loiseau, Philippe M. ; POMEL, SÉBASTIEN ; Poupon, Erwan ; CHAMPY, PIERRE ; Beniddir, Mehdi A. . Revisiting Previously Investigated Plants: A Molecular Networking-Based Study of. JOURNAL OF NATURAL PRODUCTS , v. 80, p. 1007-1014, 2017.
ORTIZ, SERGIO ; DALI-YAHIA, KAMEL ; VASQUEZ-OCMIN, PEDRO ; GROUGNET, RAPHAËL ; Grellier, Philippe ; MICHEL, SYLVIE ; Maciuk, Alexandre ; BOUTEFNOUCHET, SABRINA . Heme-binding activity of methoxyflavones from Pentzia monodiana Maire (Asteraceae). FITOTERAPIA , v. 118, p. 1-5, 2017.
Charneau, Sébastien ; CORDEIRO, THUANYDE MOURA ; BORGHETTI, FABIAN ; CALDAS OLIVEIRA, SARAHC ; BASTOS, IZABELAMARQUES DOURADO ; DE SANTANA, JAIMEMARTINS ; Grellier, Philippe . Brazilian cerrado Qualea grandiflora Mart. leaves exhibit antiplasmodial and trypanocidal activities In vitro. Pharmacognosy Magazine , v. 13, p. 668, 2017.
N?NANG OBIANG, ELVIS OTOGO ; GENTA-JOUVE, GRÉGORY ; GALLARD, JEAN-FRANÇOIS ; KUMULUNGUI, BRICE ; Mouray, Elisabeth ; Grellier, Philippe ; EVANNO, LAURENT ; Poupon, Erwan ; CHAMPY, PIERRE ; Beniddir, Mehdi A. . Pleiokomenines A and B: Dimeric Aspidofractinine Alkaloids Tethered with a Methylene Group. ORGANIC LETTERS , v. 19, p. 6180-6183, 2017.
TRIANA-VIDAL, LUZ ELENA ; CASTRO, MARIANA SOUZA ; PIRES JÚNIOR, OSMINDO RODRIGUES ; ÁLVARES, ALICE CUNHA MORALES ; DE FREITAS, SONIA MARIA ; FONTES, WAGNER ; VARGAS, JIMMY ALEXANDER GUERRERO ; ZÚIGA-BAOS, JORGE ALBERTO ; CORREIA BATISTA, ISABEL DE FÁTIMA ; Grellier, Philippe ; Charneau, Sébastien . Dendropsophin 1, a novel antimicrobial peptide from the skin secretion of the endemic Colombian frog Dendropsophus columbianus. NATURAL PRODUCT RESEARCH , v. x, p. 1-7, 2017.
D?AVILA-LEVY, CLAUDIA M. ; YURCHENKO, VYACHESLAV ; VOTPKA, JAN ; Grellier, Philippe . Protist Collections: Essential for Future Research. TRENDS IN PARASITOLOGY , v. 32, p. 840-842, 2016.
DE ALMEIDA, HUGO ; LEROUX, VINCENT ; Motta, Flávia Nader ; Grellier, Philippe ; MAIGRET, BERNARD ; Santana, Jaime M. ; BASTOS, IZABELA MARQUES DOURADO . Identification of novel Trypanosoma cruzi prolyl oligopeptidase inhibitors by structure-based virtual screening. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN , v. e1e, p. e1, 2016.
SOUIDENNE, DHIKRA ; Florent, Isabelle ; DELLINGER, MARC ; ROMDHANE, MOHAMED SALAH ; Grellier, Philippe ; FURUYA, HIDETAKA . Redescription of Dicyemennea eledones (Wagener, 1857) (Phylum Dicyemida) from Eledone cirrhosa (Lamarck, 1798) (Mollusca: Cephalopoda: Octopoda). SYSTEMATIC PARASITOLOGY , v. 93, p. 905-915, 2016.
TRAVERS, MARIE-AGNÈS ; SOW, CISSÉ ; ZIRAH, SÉVERINE ; DEREGNAUCOURT, CHRISTIANE ; CHAOUCH, SORAYA ; QUEIROZ, RAYNER M. L. ; Charneau, Sébastien ; ALLAIN, THIBAULT ; Florent, Isabelle ; Grellier, Philippe . Deconjugated Bile Salts Produced by Extracellular Bile-Salt Hydrolase-Like Activities from the Probiotic Lactobacillus johnsonii La1 Inhibit Giardia duodenalis In vitro Growth. Frontiers in Microbiology , v. 7, p. eCollect 2016, 2016.
SOUIDENNE, DHIKRA ; Florent, Isabelle ; DELLINGER, MARC ; JUSTINE, JEAN LOU ; ROMDHANE, MOHAMED SALAH ; FURUYA, HIDETAKA ; Grellier, Philippe . Diversity of apostome ciliates, spp. (Oligohymenophorea, Opalinopsidae), parasites of cephalopods of the Mediterranean Sea. Parasite , v. 23, p. 33, 2016.
GRAYFER, TATYANA D. ; Grellier, Philippe ; Mouray, Elisabeth ; DODD, ROBERT H. ; Dubois, Joëlle ; CARIOU, KEVIN . Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies. ORGANIC LETTERS , v. 18, p. 708-711, 2016.
BOSC, DAMIEN ; Mouray, Elisabeth ; COJEAN, SANDRINE ; FRANCO, CAIO HADDAD ; Loiseau, Philippe M. ; FREITAS-JUNIOR, LUCIO H. ; MORAES, CAROLINA BORSOI ; Grellier, Philippe ; Dubois, Joëlle . Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 109, p. 173-186, 2016.
MAI, HOANG LINH ; Grellier, Philippe ; PROST, ELISE ; LEMOINE, PASCALE ; POULLAIN, CYRIL ; Dumontet, Vincent ; DEGUIN, BRIGITTE ; VO, THI BACH HUE ; MICHEL, SYLVIE ; GROUGNET, RAPHAËL . Triterpenes from the exudate of Gardenia urvillei. PHYTOCHEMISTRY , v. 122, p. 193-202, 2016.
D'AVILA-LEVY, CLAUDIA MASINI ; BOUCINHA, CAROLINA ; KOSTYGOV, ALEXEI ; SANTOS, HELENA LÚCIA CARNEIRO ; MORELLI, KARINA ALESSANDRA ; GRYBCHUK-IEREMENKO, ANASTASIIA ; DUVAL, LINDA ; VOTPKA, JAN ; YURCHENKO, VYACHESLAV ; Grellier, Philippe ; LUKE?, JULIUS . Exploring the environmental diversity of kinetoplastid flagellates in the high-throughput DNA sequencing era. Memórias do Instituto Oswaldo Cruz , v. 10, p. 956-965, 2015.
VOTPKA, JAN ; D?AVILA-LEVY, CLAUDIA M. ; Grellier, Philippe ; MASLOV, DMITRI A. ; LUKE?, JULIUS ; YURCHENKO, VYACHESLAV . New Approaches to Systematics of Trypanosomatidae: Criteria for Taxonomic (Re)description. TRENDS IN PARASITOLOGY , v. 31, p. 460-469, 2015.
Charneau, Sébastien ; DE MESQUITA, MARIANA LAUNDRY ; BASTOS, IZABELA MARQUES DOURADO ; SANTANA, JAIME MARTINS ; DE PAULA, JOSÉ ELIAS ; Grellier, Philippe ; ESPINDOLA, LAILA SALMEN . In vitro investigation of Brazilian Cerrado plant extract activity against Plasmodium falciparum , Trypanosoma cruzi and T. brucei gambiense. NATURAL PRODUCT RESEARCH , v. 11, p. 1-7, 2015.
RAHUL, SURYAWANSHI ; CHANDRASHEKHAR, PATIL ; HEMANT, BORASE ; BIPINCHANDRA, SALUNKE ; Mouray, Elisabeth ; Grellier, Philippe ; SATISH, PATIL . In vitro antiparasitic activity of microbial pigments and their combination with phytosynthesized metal nanoparticles. PARASITOLOGY INTERNATIONAL , v. 64, p. 353-356, 2015.
GUILLAUME, CAROLE ; PAYRÉ, CHRISTINE ; JEMEL, IKRAM ; JEAMMET, LOUISE ; BEZZINE, SOFIANE ; NAIKA, GAJENDRA S. ; BOLLINGER, JAMES ; Grellier, Philippe ; GELB, MICHAEL H. ; SCHRÉVEL, JOSEPH ; LAMBEAU, GÉRARD ; DEREGNAUCOURT, CHRISTIANE . Anti-Plasmodium falciparum Properties of the Full Set of Human Secreted Phospholipases A. INFECTION AND IMMUNITY , v. 83, p. 2453-2465, 2015.
MAI, LINH H. ; CHABOT, GUY G. ; Grellier, Philippe ; QUENTIN, LIONEL ; Dumontet, Vincent ; POULAIN, CYRIL ; ESPINDOLA, LAILA S. ; MICHEL, SYLVIE ; VO, HUE T.B. ; DEGUIN, BRIGITTE ; GROUGNET, RAPHAËL . Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 90, p. ePUB 2014, 2015.
MWANDE MAGUENE, GABIN ; Lekana-Douki, Jean-Bernard ; Mouray, Elisabeth ; Bousquet, Till ; Grellier, Philippe ; Pellegrini, Sylvain ; TOURE NDOUO, FOUSSEYNI SAMBA ; Lebibi, Jacques ; PÉLINSKI, LYDIE . Synthesis and invitro antiplasmodial activity of ferrocenyl aminoquinoline derivatives. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 90, p. 519-525, 2015.
HAVRYLYUK, DMYTRO ; ZIMENKOVSKY, BORYS ; KARPENKO, OLEXANDR ; Grellier, Philippe ; LESYK, ROMAN . Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 85, p. 245-254, 2014.
KRYSHCHYSHYN, ANNA ; KAMINSKYY, DANYLO ; Grellier, Philippe ; LESYK, ROMAN . Trends in research of antitrypanosomal agents among synthetic heterocycles. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 85, p. 51-64, 2014.
AKONO NTONGA, PATRICK ; BALDOVINI, NICOLAS ; Mouray, Elisabeth ; Mambu, Lengo ; BELONG, PHILIPPE ; Grellier, Philippe . Activity of , , and essential oils against and mature-stage larvae of s.s.. Parasite , v. 21, p. 33, 2014.
DELLINGER, MARC ; LABAT, AMANDINE ; PERROUAULT, LOÏC ; Grellier, Philippe . Haplomyxa saranae gen. nov. et sp. nov., a New Naked Freshwater Foraminifer. PROTIST , v. 165, p. 317-329, 2014.
KAMINSKYY, DANYLO ; KRYSHCHYSHYN, ANNA ; NEKTEGAYEV, IHOR ; VASYLENKO, OLEXANDR ; Grellier, Philippe ; LESYK, ROMAN . Isothiocoumarin-3-carboxylic acid derivatives: Synthesis, anticancer and antitrypanosomal activity evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 75, p. 57-66, 2014.
BASTOS, I. ; MOTTA, F. ; GRELLIER, P. ; SANTANA, J. . Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis. Current Medicinal Chemistry , v. 20, p. 3103-3115, 2013.
GALLET, CÉCILE ; DEMONCHY, RAPHAËL ; KOPPEL, CAROLE ; Grellier, Philippe ; KOHL, LINDA . A Protein Phosphatase 1 involved in correct nucleus positioning in trypanosomes. MOLECULAR AND BIOCHEMICAL PARASITOLOGY , v. 192, p. 49-54, 2013.
LI, XU-WEN ; HERRMANN, JENNIFER ; ZANG, YI ; Grellier, Philippe ; Prado, Soizic ; MÜLLER, ROLF ; NAY, BASTIEN . Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues. Beilstein Journal of Organic Chemistry , v. 9, p. 1551-1558, 2013.
THÉVENIN, MARION ; THORET, SYLVIANE ; Grellier, Philippe ; Dubois, Joëlle . Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth. BIOORGANIC & MEDICINAL CHEMISTRY , v. 21, p. 4885-4892, 2013.
HAVRYLYUK, DMYTRO ; ZIMENKOVSKY, BORYS ; VASYLENKO, OLEXANDR ; DAY, CRAIG W. ; SMEE, DONALD F. ; Grellier, Philippe ; LESYK, ROMAN . Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 66, p. 228-237, 2013.
DUBAR, FAUSTINE ; SLOMIANNY, CHRISTIAN ; KHALIFE, JAMAL ; DIVE, DANIEL ; KALAMOU, HADIDJATOU ; GUÉRARDEL, YANN ; Grellier, Philippe ; BIOT, CHRISTOPHE . The Ferroquine Antimalarial Conundrum: Redox Activation and Reinvasion Inhibition. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , v. 52, p. 7690-7693, 2013.
Fromentin, Yann ; GABORIAUD-KOLAR, NICOLAS ; LENTA, BRUNO NDJAKOU ; Wansi, Jean Duplex ; Buisson, Didier ; Mouray, Elisabeth ; Grellier, Philippe ; Loiseau, Philippe M. ; Lallemand, Marie-Christine ; MICHEL, SYLVIE . Synthesis of novel guttiferone A derivatives: In-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 65, p. 284-294, 2013.
FAROKHI, FERESHTEH ; Grellier, Philippe ; CLÉMENT, MONIQUE ; ROUSSAKIS, CHRISTOS ; LOISEAU, PHILIPPE ; GENIN-SEWARD, EMILIE ; KORNPROBST, JEAN-MICHEL ; BARNATHAN, GILLES ; WIELGOSZ-COLLIN, GAËTANE . Antimalarial Activity of Axidjiferosides, New -Galactosylceramides from the African Sponge Axinyssa djiferi. Marine Drugs , v. 11, p. 1304-1315, 2013.
2012 de Paula, José ; Espindola, Laila ; Bodo, Bernard ; Dubost, Lionel ; Deville, Alexandre ; Grellier, Philippe ; Mambu, Lengo . Spiranthenones A and B, Tetraprenylated Phloroglucinol Derivatives from the Leaves of. Planta Medica (Internet) , v. 78, p. 459-464, 2012.
Beniddir, Mehdi A. ; Grellier, Philippe ; Rasoanaivo, Philippe ; Loiseau, Philippe M. ; Bories, Christian ; Dumontet, Vincent ; Guéritte, Françoise ; Litaudon, Marc . Diarylheptanoid Glucosides from Pyrostria major and Their Antiprotozoal Activities. European Journal of Organic Chemistry (Print) , v. 2012, p. 1039-1046, 2012.
Beniddir, Mehdi A. ; Martin, Marie-Thérèse ; Tran Huu Dau, Marie-Elise ; Grellier, Philippe ; Rasoanaivo, Philippe ; Guéritte, Françoise ; Litaudon, Marc . Goniomedines A and B: Unprecedented Bisindole Alkaloids Formed through Fusion of Two Indole Moieties via a Dihydropyran Unit. Organic Letters (Print) , v. 14, p. 4162-4165, 2012.
Dalla-Vechia, Luciana ; Dassonville-Klimpt, Alexandra ; Grellier, Philippe ; Sonnet, Pascal ; Gosmann, Grace ; Gnoatto, Simone C. B. . ChemInform Abstract: The Beckmann Rearrangement Applied to Ursolic Acid with Antimalarial Activity in Medicinal Chemistry Studies.. ChemInform , v. 43, p. no-no, 2012.
Fromentin, Yann ; Grellier, Philippe ; Wansi, Jean Duplex ; Lallemand, Marie-Christine ; Buisson, Didier . Yeast-Mediated Xanthone Synthesis through Oxidative Intramolecular Cyclization. Organic Letters (Print) , v. x, p. 120917151551000-x, 2012.
Morel, Sylvie ; Landreau, Anne ; Nguyen, Van Hung ; Derbré, Séverine ; Grellier, Philippe ; Le Pape, Patrice ; Pagniez, Fabrice ; Litaudon, Marc ; Richomme, Pascal . Preparative Isolation, Fast Centrifugal Partition Chromatography Purification and Biological Activity of Cajaflavanone from Derris ferruginea Stems. Phytochemical Analysis , v. 23, p. 152-158, 2012.
Muoz-Durango, Katalina ; Maciuk, Alexandre ; Harfouche, Abha ; Torijano-Gutiérrez, Sandra ; Jullian, Jean-Christophe ; Quintin, Jérôme ; Spelman, Kevin ; Mouray, Elisabeth ; Grellier, Philippe ; Figadère, Bruno . Detection, Characterization, and Screening of Heme-Binding Molecules by Mass Spectrometry for Malaria Drug Discovery. Analytical Chemistry (Washington) , v. 84, p. 3324-3329, 2012.
ZELISKO, NATALIYA ; ATAMANYUK, DMYTRO ; VASYLENKO, OLEXANDR ; Grellier, Philippe ; LESYK, ROMAN . Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , v. 22, p. 7071-7074, 2012.
Cebrian-Torrejon, Gerardo ; Spelman, Kevin ; Munoz-Durango, Katalina ; Cech, Nadja B. ; Maciuk, Alexandre ; Gutierrez, Sandra Torijano ; Poupon, Erwan ; Fournet, Alain ; Ferreira, Maria Elena ; Leblanc, Karine ; Figadere, Bruno ; Grellier, Philippe ; Arias, Antonieta Rojas de . The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparum. Revista Brasileira de Farmacognosia (Impresso) , v. 21, p. 652-661, 2011.
Guillon, Jean ; Desplat, Vanessa ; Grellier, Philippe ; Forfar, Isabelle ; Ravanello, FranÃois ; Sonnet, Pascal ; Mouray, Elisabeth ; Jarry, Christian ; Belisle-Fabre, Solene ; LÃger, Jean-Michel ; Pinaud, NoÃl ; DÃlÃris, GÃrard ; Moreau, StÃphane ; MulliÃ, Catherine ; Gosmann, Grace ; Le-Naour, Augustin . New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: Synthesis, and in vitro antimalarial activity â Part II. European Journal of Medicinal Chemistry , v. 46, p. 2310-2326, 2011.
Mwande-Maguene, Gabin ; Jakhlal, Jouda ; Lekana-Douki, Jean-Bernard ; Mouray, Elisabeth ; Bousquet, Till ; Pellegrini, Sylvain ; Grellier, Philippe ; Ndouo, Fousseyni Samba Toure ; Lebibi, Jacques ; Pelinski, Lydie . One-pot microwave-assisted synthesis and antimalarial activity of ferrocenyl benzodiazepines. New Journal of Chemistry (1987) , v. 35, p. 2412, 2011.
Marti, Guillaume ; Eparvier, Véronique ; Moretti, Christian ; Prado, Soizic ; Grellier, Philippe ; Hue, Nathalie ; Thoison, Odile ; Delpech, Bernard ; Guéritte, Françoise ; Litaudon, Marc . Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae). Phytochemistry , v. 71, p. 964-974, 2010.
Bourjot, Mélanie ; Apel, Cécile ; Martin, Marie-Thérèse ; Grellier, Philippe ; Nguyen, Van ; Guéritte, Françoise ; Litaudon, Marc . Antiplasmodial, Antitrypanosomal, and Cytotoxic Activities of Prenylated Flavonoids Isolated from the Stem Bark of. Planta Medica (Internet) , v. 76, p. 1600-1604, 2010.
Berg, M. ; Kohl, L. ; Van der Veken, P. ; Joossens, J. ; Al-Salabi, M. I. ; Castagna, V. ; Giannese, F. ; Cos, P. ; Versees, W. ; Steyaert, J. ; GRELLIER, P. ; Haemers, A. ; Degano, M. ; Maes, L. ; de Koning, H. P. ; Augustyns, K. . Evaluation of Nucleoside Hydrolase Inhibitors for Treatment of African Trypanosomiasis. Antimicrobial Agents and Chemotherapy (Online) , v. 54, p. 1900-1908, 2010.
Bastos, Izabela M.D. ; Motta, Flávia Nader ; Charneau, Sébastien ; Augustyns, Koen ; Dubost, Lionel ; Motta, FlÃvia Nader ; Santana, Jaime M. ; Charneau, SÃbastien ; Grellier, Philippe . Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice. Microbes and Infection , v. 12, p. 457-466, 2010.
Duez, Stéphanie ; Coudray, Laëtitia ; Mouray, Elisabeth ; Grellier, Philippe ; Dubois, Joëlle . Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues. Bioorganic & Medicinal Chemistry (Print) , v. 18, p. 543-556, 2010.
Grellier, Philippe ; Marozien, Audron ; Nivinskas, Henrikas ; arlauskas, Jonas ; Aliverti, Alessandro ; nas, Narimantas . Antiplasmodial activity of quinones: Roles of aziridinyl substituents and the inhibition of Plasmodium falciparum glutathione reductase. Archives of Biochemistry and Biophysics (Print) , v. 494, p. 32-39, 2010.
Demonchy, R. ; Blisnick, T. ; Deprez, C. ; Toutirais, G. ; Loussert, C. ; Marande, W. ; GRELLIER, P. ; Bastin, P. ; Kohl, L. . Kinesin 9 family members perform separate functions in the trypanosome flagellum. The Journal of Cell Biology , v. 187, p. 615-622, 2009.
Florent, Isabelle ; Grellier, Philippe ; Porcel, Betina M ; BrÃhÃlin, Laurent ; Guillaume, Elodie ; Artiguenave, FranÃois ; Da Silva, Corinne ; Gascuel, Olivier ; Charneau, SÃbastien ; Wincker, Patrick ; MarÃchal, Eric . A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism. BMC Genomics , v. 10, p. 235, 2009.
Henchiri, Hichem ; Bodo, Bernard ; Deville, Alexandre ; Dubost, Lionel ; Zourgui, Lazhar ; Raies, Aly ; Grellier, Philippe ; Mambu, Lengo . Sesquiterpenoids from Teucrium ramosissimum. Phytochemistry , v. 70, p. 1435-1441, 2009.
Paunescu, Emilia ; Susplugas, Sophie ; Boll, Emmanuelle ; Varga, Richard ; Mouray, Elisabeth ; Grosu, Ion ; Grellier, Philippe ; Melnyk, Patricia . Replacement of the 4-Hydroxy Group of Amodiaquine and Amopyroquine by Aromatic and Aliphatic Substituents: Synthesis and Antimalarial Activity. Chemmedchem (Internet) , v. 4, p. 549-561, 2009.
Nguyen, Ngoc Tuan ; Pham, Van Cuong ; Litaudon, Marc ; Gueritte, Francoise ; Grellier, Philippe ; Nguyen, Van Tuyen ; Nguyen, Van Hung . Antiplasmodial Alkaloids from. Journal of Natural Products (Print) , v. 71, p. 2057-2059, 2008.
Guillon, Jean ; Moreau, Stéphane ; Mouray, Elisabeth ; Sinou, Véronique ; Forfar, Isabelle ; Fabre, Solene Belisle ; Desplat, Vanessa ; Millet, Pascal ; Parzy, Daniel ; Jarry, Christian ; Grellier, Philippe . New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: Synthesis, and in vitro antimalarial activity. Bioorganic & Medicinal Chemistry (Print) , v. 16, p. 9133-9144, 2008.
Paunescu, E. ; Susplugas, S. ; Boll, E. ; Varga, R. A. ; Mouray, E. ; GRELLIER, P. ; Melnyk, P. . Synthesis and Antimalarial Activity of New Amino Analogues of Amodiaquine. Medicinal Chemistry (Hilversum) , v. 4, p. 407-425, 2008.
De Cian, Anne ; Grellier, Philippe ; Mouray, Elisabeth ; Depoix, Delphine ; Bertrand, Hélène ; Monchaud, David ; Teulade-Fichou, Marie-Paule ; Mergny, Jean-Louis ; Alberti, Patrizia . Telomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds. ChemBioChem (Print) , v. 9, p. 2730-2739, 2008.
Robert, Vincent ; Bourgouin, Catherine ; Depoix, Delphine ; Thouvenot, Catherine ; Lombard, Marie-Noëlle ; Grellier, Philippe . Malaria and obesity: obese mice are resistant to cerebral malaria. Malaria Journal (Online) , v. 7, p. 81, 2008.
Ramanandraibe, Voahangy ; Grellier, Philippe ; Martin, Marie-Thérèse ; Deville, Alexandre ; Joyeau, Roger ; Ramanitrahasimbola, David ; Mouray, Elisabeth ; Rasoanaivo, Philippe ; Mambu, Lengo . Antiplasmodial Phenolic compounds from. Planta Medica (Internet) , v. 74, p. 417-421, 2008.
Grellier, Philippe ; GRELLIER, P. ; BENACH, J. ; LABAIED, M. ; GIL, H. ; MONSALVE, G. ; ALFONSO, R. ; SAWYER, L. ; LIN, L. ; STEIERT, M. ; DUPUIS, K. ; Gil, Horacio ; Charneau, SÃbastien ; Labaied, Mehdi ; Steiert, Matthias ; Dupuis, Kent ; Sawyer, Lynette ; Lin, Lily ; Monsalve, Gloria ; Benach, Jorge ; Alfonso, Ryan . Photochemical inactivation with amotosalen and long-wavelength ultraviolet light of Plasmodium and Babesia in platelet and plasma components. Transfusion (Arlington, Va.) , v. 48, p. 1676-1684, 2008.
Gnoatto, Simone C.B. ; Guillon, Jean ; Grellier, Philippe ; Gosmann, Grace ; Demailly, Catherine ; Verli, Hugo ; Ferreira, Thais B. ; Sonnet, Pascal ; Nascimento, Sophie Da ; Vechia, Luciana Dalla ; Susplugas, Sophie ; Dassonville-Klimpt, Alexandra ; Zimmer, Karine R. . Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents. Bioorganic & Medicinal Chemistry (Print) , v. 16, p. 771-782, 2008.
Delarue-Cochin, Sandrine ; Grellier, Philippe ; Maes, Louis ; Mouray, Elisabeth ; Sergheraert, Christian ; Melnyk, Patricia . Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline. European Journal of Medicinal Chemistry , v. 43, p. 2045-2055, 2008.
GRELLIER, P. . Trypanosoma cruzi Prolyl Oligopeptidase Tc80 Is Involved in Nonphagocytic Mammalian Cell Invasion by Trypomastigotes. The Journal of Biological Chemistry (Print) , v. 276, p. 47078-47086, 2001.
GRELLIER, P. . Synthesis and Activity of Pyrrolidinyl- and Thiazoldinyl-Dipeptides Derivatives as Inhibitors of the Tc80 Prolyl Oligopeptidase from Trypanosoma cruzi.. European Journal of Medicinal Chemistry , v. 35, p. 1-10, 2000.
GRELLIER, P. . Selective and reversible effects of vinca alkaloids on Trypanosoma cruzi epimastigote forms : blockage of cytokinesis without inhibition of the organelle duplication. Cell Motility and the Cytoskeleton , v. 42, p. 36-47, 1999.
GRELLIER, P. . Identification and synthesis of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library. Chemical and Pharmaceutical Bulletin , v. 47, p. 194-199, 1999.
GRELLIER, P. . Automated parallel synthesis of a tetrahydroisoquinolin-based library : potential prolyl endopeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters , v. 9, p. 437-442, 1999.
GRELLIER, P. . Involvement of calyculin A-sensitive phosphatase(s) in the differentiation of Trypanosoma cruzi trypomastigotes to amastigotes. Molecular and Biochemical Parasitology , v. 98, p. 239-252, 1999.
GRELLIER, P. . Plasmepsin II, an acidic hemoglobinase from the Plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton. The Journal of Biological Chemistry , v. 274, p. 14218-14223, 1999.
GRELLIER, P. . Host cell and malarial targets for Docetaxel (TaxotereR) during the erythrocytic development of Plasmodium falciparum. The Journal of Eukaryotic Microbiology , v. 45, p. 171-183, 1998.
GRELLIER, P. . Chemotherapy of experimental Trypanosoma cruzi infection with specific IgG-chlorambucil conjugate. Laboratory Investigation , v. 78, p. 707-714, 1998.
GRELLIER, P. . Photodecontamination of blood components : advantages and drawbacks. Clin Heemorheol Microcircul, v. 18, p. 299-308, 1998.
GRELLIER, P. . Trypanosoma cruzi 80 kDa proteinase with specificity to collagen I and IV. Biochemical Journal (London) , v. 324, p. 129-137, 1997.
GRELLIER, P. . New trends in chemoterapy on human and animal blood parasites. Zeitschrift Für Parasitenkunde (Parasitology Research) , v. 82, p. 283-284, 1996.
GRELLIER, P. . Antimalarial activity of alkaloids isolated from Cryptolepis sanguinolenta, cryptolepine and isocryptolepine. Phyotherapy Res, v. 10, p. 317-321, 1996.
GRELLIER, P. . In vitro and in vivo inhibition of erythrocytic development of malarial parasites by docetaxel (Taxotere).. Antimicrobial Agents and Chemotherapy , v. 40, p. 358-361, 1996.
GRELLIER, P. . Bisbenzylisoquinolines as modulators of chloroquinoresistance in Plamodium falciparum and MDR in tumor cell. Antimicrobial Agents and Chemotherapy , v. 40, p. 1476-1481, 1996.
GRELLIER, P. . Actin in the acrosome of the spermatozoa of the crab, Cancer Pagurus L. (Decapoda, Crustacea. Molecular Reproduction and Development , v. 38, p. 178-186, 1994.
GRELLIER, P. . Inhibition of the intraerythrocytic development of Plasmodium falciparum and Babesia divergens by HMG-CoA reductase inhibitors. Antimicrobial Agents and Chemotherapy , v. 38, p. 1144-1148, 1994.
GRELLIER, P. . Interaction between docetaxel (Taxotere) and Plasmodium falciparum-infected erythrocytes. PNAS. Proceedings of the National Academy of Sciences of the United States of America , v. 91, p. 8472-8476, 1994.
GRELLIER, P. . A large polygenic family expressed during the erythrocytic schizogony of Plasmodium falciparum. Molecular and Biochemical Parasitology , v. 68, p. 221-233, 1994.
GRELLIER, P. . Plasmodium falciparum proteinase: cloning of the putative gene coding for the merozoite proteinase for erythrocyte invasion (MPEI) and determination of hydrolysis sites of spectrin by Pf37 proteinase. Memórias do Instituto Oswaldo Cruz , v. 89, p. 45-47, 1994.
GRELLIER, P. . Characterization of a new 60 kDa rhoptry protein of Plasmodium falciparum expressed in late schizogony. Biology Of The Cell, v. 82, p. 129-138, 1994.
GRELLIER, P. . Plasmodium falciparum proteinases and red blood cell invasion. Parasitology (London) , v. 35, p. 103-105, 1993.
GRELLIER, P. . New approaches in in vitro cultures of Plasmodium falciparum and Babesia divergens by using serum-free medium. Memórias do Instituto Oswaldo Cruz , v. 87, p. 71-75, 1992.
GRELLIER, P. . Purification and characterization of a new 120 kDa alkaline proteinase of Trypanosoma cruzi.. Biochemical and Biophysical Research Communications , v. 187, p. 1466-1473, 1992.
GRELLIER, P. . Characterization of a monoclonal antibody to human proacrosin and its use in acrosomal status evaluation. European Journal of Histochemistry , v. 39, p. 273-282, 1991.
GRELLIER, P. . Isolation and characterization of a soluble antigen complex of Plasmodium falciparum with pyrogenic propertie. Acta Patho Logyca Microbiol Immunol Sscand, v. 99, p. 21-29, 1991.
GRELLIER, P. . Lipid traffic between high density lipoproteins and the Plasmodium falciparum infected red blood cells. International Journal of Biochemistry & Cell Biology , v. 112, p. 267-277, 1991.
GRELLIER, P. . Identification and localization of a soluble antigen, Ag2, of 136 kDa from Plasmodium falciparum in vitro cultures. Acta Pathologyca Immunol Scand, v. 99, p. 155-162, 1991.
GRELLIER, P. . Peptide derivatives specific for a Plasmodium falciparum proteinase inhibit the human erythrocyte invasion by merozoite. European Journal of Medicinal Chemistry , v. 34, p. 3029-3035, 1991.
GRELLIER, P. . The native form of the Plasmodium falciparum Pf68 neutral proteinase is an Mr 105,000 polypeptide. Zeitschrift Für Parasitenkunde (Parasitology Research) , v. 77, p. 720-722, 1991.
GRELLIER, P. . Induction in vitro de la schizogonie de Plasmodium falciparum par les lipoprotéines humaines de haute densité (HDL). C R Acad Sci Paris, v. 311, p. 361-367, 1990.
GRELLIER, P. . Biochemical characterization, localization and immunostimulating properties of a soluble glycoprotein, Ag1, isolated from in vitro cultures of Plasmodium falciparum. Zeitschrift Für Parasitenkunde (Parasitology Research) , v. 76, p. 657-661, 1990.
GRELLIER, P. . Purification and characterization of a Plasmodium falciparum neutral endopeptidase: identification in purified merozoites. Zeitschrift Für Parasitenkunde (Parasitology Research) , v. 75, p. 455-460, 1989.
GRELLIER, P. . Neutral proteases involved in the reinvasion of erythrocytes by Plasmodium merozoites. Biology Of The Cell, v. 64, p. 233-245, 1988.
GRELLIER, P. . Peptide derivatives specific for a Plasmodium falciparum protease involved in red blood cell invasion by merozoites. Peptide Chemistry And Biology, v. 12, p. 662-663, 1987.

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