Alexandre Emmanuel Escargueil

Pós-doutorado

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Orientou

Produções bibliográficas

• MÉSANGE, PAUL ; BOUYGUES, ANAÏS ; FERRAND, NATHALIE ; SABBAH, MICHÈLE ; Escargueil, Alexandre E. ; SAVINA, ARIEL ; CHIBAUDEL, BENOIST ; TOURNIGAND, CHRISTOPHE ; ANDRÉ, THIERRY ; de Gramont, Aimery ; Larsen, Annette K. . Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of Status. CLINICAL CANCER RESEARCH , v. 24, p. 2548-2558, 2018.

• PRÉVOST, SÉBASTIEN ; DEZAIRE, AMBRE ; ESCARGUEIL, ALEXANDRE . Intramolecular Aryne-Furan Cycloadditions for the Synthesis of Anticancer Naphthalimides. JOURNAL OF ORGANIC CHEMISTRY , v. 83, p. 4871-4881, 2018.

• ZAGHOUANI, MEHDI ; GAYRAUD, OSCAR ; JACTEL, VINCENT ; PRÉVOST, SÉBASTIEN ; DEZAIRE, AMBRE ; SABBAH, MICHÈLE ; ESCARGUEIL, ALEXANDRE ; LAI, THANH-LAN ; LE'CLAINCHE, CHRISTOPHE ; ROCQUES, NATHALIE ; ROMERO, STÉPHANE ; GAUTREAU, ALEXIS ; BLANCHARD, FLORENT ; FRISON, GILLES ; NAY, BASTIEN . Multifaceted Study on a Cytochalasin Scaffold: Lessons on Reactivity, Multidentate Catalysis, and Anticancer Properties. CHEMISTRY-A EUROPEAN JOURNAL , v. 24, p. 16686-16691, 2018.

• E. ESCARGUEIL, ALEXANDRE ; PRADO, SOIZIC ; DEZAIRE, AMBRE ; CLAIRAMBAULT, JEAN ; K. LARSEN, ANNETTE ; G. SOARES, DANIELE . Genotype- or Phenotype-Targeting Anticancer Therapies? Lessons from Tumor Evolutionary Biology. CURRENT PHARMACEUTICAL DESIGN , v. 22, p. 6625-6644, 2017.

• BLANCHET, ELODIE ; PRADO, SOIZIC ; STIEN, DIDIER ; OLIVEIRA DA SILVA, JOCIVÂNIA ; FERANDIN, YOAN ; BATAILLER, NICOLE ; INTERTAGLIA, LAURENT ; ESCARGUEIL, ALEXANDRE ; LAMI, RAPHAËL . Quorum Sensing and Quorum Quenching in the Mediterranean Seagrass Posidonia oceanica Microbiota. FRONTIERS IN MARINE SCIENCE , v. 4, p. 218, 2017.

• ZANG, YI ; GENTA-JOUVE, GRÉGORY ; RETAILLEAU, PASCAL ; ESCARGUEIL, ALEXANDRE ; MANN, STÉPHANE ; NAY, BASTIEN ; PRADO, SOIZIC . Talaroketals A and B, unusual bis(oxaphenalenone) spiro and fused ketals from the soil fungus Talaromyces stipitatus ATCC 10500. ORGANIC & BIOMOLECULAR CHEMISTRY , v. 14, p. 2691-2697, 2016.

• LIMA, MICHELLE ; BOUZID, HANA ; Soares, Daniele G. ; SELLE, FRÉDÉRIC ; MOREL, CLAIRE ; GALMARINI, CARLOS M. ; HENRIQUES, JOÃO A. P. ; Larsen, Annette K. ; Escargueil, Alexandre E. . Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair. Oncotarget , v. 7, p. 25885, 2016.

• ZANG, YI ; GENTA-JOUVE, GRÉGORY ; Escargueil, Alexandre E. ; Larsen, Annette K. ; GUEDON, LAURA ; NAY, BASTIEN ; PRADO, SOIZIC . Antimicrobial Oligophenalenone Dimers from the Soil Fungus. JOURNAL OF NATURAL PRODUCTS , v. 79, p. 2991-2996, 2016.

• LORZ, ALEXANDER ; LORENZI, TOMMASO ; CLAIRAMBAULT, JEAN ; ESCARGUEIL, ALEXANDRE ; PERTHAME, BENOÎT . Modeling the Effects of Space Structure and Combination Therapies on Phenotypic Heterogeneity and Drug Resistance in Solid Tumors. BULLETIN OF MATHEMATICAL BIOLOGY , v. 77, p. 1-22, 2015.

• ZANG, YI ; GENTA-JOUVE, GRÉGORY ; SUN, TITHNARA ANTHONY ; LI, XUWEN ; DIDIER, BUISSON ; MANN, STÉPHANE ; MOURAY, ELISABETH ; Larsen, Annette K. ; Escargueil, Alexandre E. ; NAY, BASTIEN ; PRADO, SOIZIC . Unexpected talaroenamine derivatives and an undescribed polyester from the fungus Talaromyces stipitatus ATCC10500. PHYTOCHEMISTRY , v. 119, p. 70-75, 2015.

• CHISHOLM, R. H. ; LORENZI, T. ; LORZ, A. ; Larsen, A. K. ; ALMEIDA, L. N. D. ; Escargueil, A. ; CLAIRAMBAULT, J. . Emergence of Drug Tolerance in Cancer Cell Populations: An Evolutionary Outcome of Selection, Nongenetic Instability, and Stress-Induced Adaptation. CANCER RESEARCH , v. 75, p. 930-939, 2015.

• ROCCA, CÉLINE J ; SOARES, DANIELE G ; BOUZID, HANA ; HENRIQUES, JOÃO A P ; LARSEN, Annette K ; Escargueil, Alexandre E . BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder. CELL CYCLE , v. 14, p. 2080-2090, 2015.

• MÉSANGE, PAUL ; POINDESSOUS, Virginie ; SABBAH, MICHÈLE ; Escargueil, Alexandre E. ; de Gramont, Aimery ; Larsen, Annette K. . Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor.. Oncotarget , v. 5, p. 4709-4721, 2014.

• BORDIN, DIANA L. ; LIMA, MICHELLE ; LENZ, GUIDO ; Saffi, Jenifer ; MEIRA, LISIANE B. ; MÉSANGE, PAUL ; Soares, Daniele G. ; Larsen, Annette K. ; Escargueil, Alexandre E. ; Henriques, João A.P. . DNA alkylation damage and autophagy induction. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH , v. 753, p. 91-99, 2013.

• MATUO, R. ; SOUSA, F.G. ; Bonatto, D. ; MIELNICZKI-PEREIRA, A.A. ; SAFFI, J. ; SOARES, D.G. ; ESCARGUEIL, A.E. ; LARSEN, A.K. ; HENRIQUES, J.A.P. . ATP-dependent chromatin remodeling and histone acetyltransferases in 5-FU cytotoxicity in Saccharomyces cerevisiae. GENETICS AND MOLECULAR RESEARCH , v. 12, p. 1440-1456, 2013.

• PETITPREZ, AMÉLIE ; POINDESSOUS, Virginie ; OUARET, DJAMILA ; REGAIRAZ, MARIE ; BASTIAN, GÉRARD ; Guérin, Eric ; Escargueil, Alexandre E. ; Larsen, Annette K. . Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status. INTERNATIONAL JOURNAL OF ONCOLOGY , v. 42, p. 1644-1653, 2013.

• SOUSA, F. G. ; MATUO, R. ; Soares, D. G. ; Escargueil, A. E. ; Henriques, J. A. P. ; Larsen, A. K. ; SAFFI, J. . PARPs and the DNA damage response. Carcinogenesis (New York. Online) , v. 33, p. 1433-1440, 2012.

• Matuo, Renata ; SOUSA, FABRÍCIO G. ; Soares, Daniele G. ; BONATTO, Diego ; Saffi, Jenifer ; Escargueil, Alexandre E. ; Larsen, Annette K. ; Henriques, João Antonio Pêgas . Saccharomyces cerevisiae as a model system to study the response to anticancer agents. Cancer Chemotherapy and Pharmacology , v. 70, p. 491-502, 2012.

• Soares, Daniele G. ; Larsen, Annette K. ; Escargueil, Alexandre E. . The DNA damage response to monofunctional anticancer DNA binders. Drug Discovery Today. Disease Models , v. 9, p. e59-e67, 2012.

• Soares, Daniele&nbsp ; Battistella, Aude ; Rocca, Céline&nbsp ; Matuo, Renata ; Henriques, João&nbsp ; Larsen, Annette&nbsp ; Escargueil, Alexandre&nbsp . Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906. Biochemical Journal (London. 1984) , v. 437, p. 63-73, 2011.

• Soares, D. G. ; Machado, M. S. ; Rocca, C. J. ; Poindessous, V. ; Ouaret, D. ; Sarasin, A. ; Galmarini, C. M. ; Henriques, J. A. P. ; Escargueil, A. E. ; Larsen, A. K. . Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells. Molecular Cancer Therapeutics , v. 10, p. 1481-1489, 2011.

• Poindessous, V. ; Ouaret, D. ; El Ouadrani, K. ; Battistella, A. ; Megalophonos, V. F. ; Kamsu-Kom, N. ; Petitprez, A. ; Escargueil, A. E. ; Boudou, P. ; Dumont, S. ; Cervera, P. ; Flejou, J.-F. ; Andre, T. ; Tournigand, C. ; Chibaudel, B. ; de Gramont, A. ; Larsen, A. K. . EGFR- and VEGF(R)-Targeted Small Molecules Show Synergistic Activity in Colorectal Cancer Models Refractory to Combinations of Monoclonal Antibodies. Clinical Cancer Research (Print) , v. 17, p. 6522-6530, 2011.

• Matuo, Renata ; Sousa, Fabrício Garmus ; Escargueil, Alexandre E. ; Soares, Daniele G. ; Grivicich, Ivana ; Saffi, Jenifer ; Larsen, Annette K. ; Henriques, João Antonio Pêgas . DNA repair pathways involved in repair of lesions induced by 5-fluorouracil and its active metabolite FdUMP. Biochemical Pharmacology , v. 79, p. 147-153, 2010.

• Rocca, Céline J. ; POINDESSOUS, Virginie ; Soares, Daniele G. ; Ouadrani, Karima El ; SARASIN, Alain ; Guérin, Eric ; de Gramont, Aimery ; Henriques, João A.P. ; Escargueil, Alexandre E. ; Larsen, Annette K. . The NER proteins XPC and CSB, but not ERCC1, regulate the sensitivity to the novel DNA binder S23906: Implications for recognition and repair of antitumor alkylators. Biochemical Pharmacology , v. 80, p. 335-343, 2010.

• Matuo, Renata ; Sousa, Fabrício Garmus ; ESCARGUEIL, Alexandre Emmanuel ; Grivicich, Ivana ; Garcia-Santos, Daniel ; Chies, José Artur Bogo ; Saffi, Jenifer ; Larsen, Annette K. ; Henriques, João Antonio Pêgas . 5-Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line. JAT. Journal of Applied Toxicology , v. 29, p. 308-316, 2009.

• Escargueil, Alexandre E. ; SOARES, Daniele Grazziotin ; Salvador, Mirian ; Larsen, Annette K. ; HENRIQUES, João Antonio Pegas . What histone code for DNA repair?. Mutation Research. Reviews in Mutation Research (Print) , v. 658, p. 259-270, 2008.

• Escargueil, A. E. ; Poindessous, V. ; Soares, D. G. ; Sarasin, A. ; Cook, P. R. ; Larsen, A. K. . Influence of irofulven, a transcription-coupled repair-specific antitumor agent, on RNA polymerase activity, stability and dynamics in living mammalian cells. Journal of Cell Science , v. 121, p. 1275-1283, 2008.

• Escargueil, Alexandre&nbsp ; Larsen, Annette&nbsp . Mitosis-specific MPM-2 phosphorylation of DNA topoisomerase II? is regulated directly by protein phosphatase 2A. Biochemical Journal (London. 1984) , v. 403, p. 235, 2007.

• Soares, D. G. ; Escargueil, A. E. ; Poindessous, V. ; Sarasin, A. ; de Gramont, A. ; Bonatto, D. ; Henriques, J. A. P. ; Larsen, A. K. . From the Cover: Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743. Proceedings of the National Academy of Sciences of the United States of America , v. 104, p. 13062-13067, 2007.

• Orlowski, S. ; Martin, S. ; Escargueil, A. . P-glycoprotein and `lipid rafts : some ambiguous mutual relationships (floating on them, building them or meeting them by chance?). Cellular and Molecular Life Sciences (Printed ed.) , v. 63, n.9, p. 1038-1059, 2006.

• Skladanowski, A. ; COME, M G ; SABISZ, M ; Escargueil, A. E. ; LARSEN, A K . Downregulation of DNA topoisomerase IIalpha leads to prolonged cell cycle transit in G2 and early M and increased survival to microtubule-interacting agents. Molecular Pharmacology (Print) , n.3, p. 625-634, 2005.

• Iborra, F. J. ; Escargueil, A. E. ; KWEK, K Y ; AKOULITCHEV, A ; COOK, P R . Molecular cross-talk between the transcription, translation, and nonsense-mediated decay machineries. Journal of Cell Science , v. 117, n.6, p. 899-906, 2004.

• LARSEN, Annette K ; Escargueil, Alexandre E ; Skladanowski, Andrzej . Catalytic topoisomerase II inhibitors in cancer therapy. Pharmacology & Therapeutics (Oxford) , v. 99, n.2, p. 167-181, 2003.

• Garrigues, A. ; Escargueil, A. E. ; ORLOWSKI, S . The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane. Proceedings of the National Academy of Sciences of the United States of America , v. 99, n.16, p. 10347-10352, 2002.

• Escargueil, A. E. ; PLISOV, S Y ; SKLADANOWSKI, A ; BORGNE, A ; MEIJER, L ; GORBSKY, G J ; LARSEN, A K . Recruitment of cdc2 kinase by DNA topoisomerase II is coupled to chromatin remodeling. The FASEB Journal (Online) , n.12, p. 2288-2290, 2001.

• Larsen, Annette K. ; Escargueil, Alexandre E. ; Skladanowski, Andrzej . Resistance mechanisms associated with altered intracellular distribution of anticancer agents. Pharmacology & Therapeutics (Oxford) , v. 85, n.3, p. 217-229, 2000.

• Escargueil, A. E. ; PILSOV, S Y ; Filhol, O ; COCHET, C ; LARSEN, A K . Mitotic Phosphorylation of DNA Topoisomerase II alpha by Protein Kinase CK2 Creates the MPM-2 Phosphoepitope on Ser-1469. The Journal of Biological Chemistry (Print) , v. 275, p. 34710-34718, 2000.

• Scala, Denis ; Escargueil, Alexandre E. ; Couprie, Janine ; Larsen, Annette K. . The catalytic activities of DNA topoisomerase II are most closely associated with the DNA cleavage/religation steps. Biochimie (Paris. Print) , v. 81, p. 771-779, 1999.

• LARSEN, Annette K ; ESCARGUEIL, Alexandre Emmanuel . Les cibles liées à la réplication, à l?expression et à la stabilité du génome. In: Axel Kahn; Eric Raymond. (Org.). Thérapie ciblée des cancers. : , 2008, v. 2, p. -.

• LARSEN, Annette K ; ESCARGUEIL, Alexandre Emmanuel ; SKLADANOWSKI, A . From DNA damage to G2 arrest: The many roles of topoisomerase II.. In: Laurent MEIJER. (Org.). Prog. Cell Cycle Res. : , 2003, v. 5, p. 295-300.

• ESCARGUEIL, Alexandre Emmanuel . Implication des voies Fas et NF-kB dans la modulation du pouvoir oncogénique des mutants de l?EGFR dans le cancer du poumon. La lettre du Cancérologue, 01 jun. 2011.

• ESCARGUEIL, Alexandre Emmanuel . Patron et dynamique de l?instabilité génomique du cancer pancréatique métastatique. La lettre du Cancérologue, 01 fev. 2011.

• ESCARGUEIL, Alexandre Emmanuel . Changements protéomiques induits par les variations du nombre de copie des gènes dans les cellules cancéreuses. La lettre du Cancérologue, 01 out. 2010.

• ESCARGUEIL, Alexandre Emmanuel . Mécanisme de radio-sensibilisation des cellules de tumeurs pancréatiques par l?AZD7762, un nouvel inhibiteur sélectif des kinases Chk1/Chk2. La lettre du Cancérologue, 01 jul. 2010.

• ESCARGUEIL, Alexandre Emmanuel . Acquisition rapide et réversible d?une tolérance aux médicaments anticancéreux dans une population de cellules cancéreuses génétiquement homogène. La lettre du Cancérologue, 01 jul. 2010.

• ESCARGUEIL, Alexandre Emmanuel . Progression tumorale et hétérogénéité génomique. La lettre du Cancérologue, 01 abr. 2010.

• ESCARGUEIL, Alexandre Emmanuel . FKBP51 régule négativement Akt et modifie la réponse des cellules cancéreuses vis-à-vis des médicaments chimio-thérapeutiques. La lettre du Cancérologue, 01 set. 2009.

• ESCARGUEIL, Alexandre Emmanuel . Cancérogénèse induite par l?expression d?oncogène, limitée aux cellules souches. La lettre du Cancérologue, 01 jun. 2009.

• ESCARGUEIL, Alexandre Emmanuel . Méthode non-invasive pour prédire la réponse tumorale à la gemcitabine grâce à l?utilisation de la tomographie par émission de positron. La lettre du Cancérologue, 01 jun. 2009.

• ESCARGUEIL, Alexandre Emmanuel . Association entre niveaux d?espèces d?oxygène réactives et radiorésistance des cellules souches cancéreuses. La lettre du Cancérologue, 01 jun. 2009.

• ESCARGUEIL, Alexandre Emmanuel . Rôle de la méthylation de l?ADN dans le contrôle de l?expression des microARNs responsables de la suppression des métastases des cancers humains. La lettre du Cancérologue, 01 set. 2008.

• ESCARGUEIL, Alexandre Emmanuel . Combiner le lapatinib avec un inhibiteur de l?activité ADAM a un effet synergique sur l?inhibition de croissance. La lettre du Cancérologue, 01 set. 2008.

• ESCARGUEIL, Alexandre Emmanuel . Cibler PML pour éradiquer les cellules leucémiques initiatrices. La lettre du Cancérologue, 01 jul. 2008.

• ESCARGUEIL, Alexandre Emmanuel . TWIST est directement régulé par HIF-1alpha et promeut la formation de metastases. La lettre du Cancérologue, 01 maio 2008.

• ESCARGUEIL, Alexandre Emmanuel . L?expression de l?isoforme M2 de la pyruvate kinase est importante pour la croissance tumorale. La lettre du Cancérologue, 01 maio 2008.

• ESCARGUEIL, Alexandre Emmanuel . Rôle des microARNs endogènes humains dans la suppression des métastases du cancer du sein. La lettre du Cancérologue, 01 maio 2008.

• ESCARGUEIL, Alexandre Emmanuel . Nouvelle technologie pour isoler les cellules tumorales circulantes présentes dans le sang des patients atteints de cancer. La lettre du Cancérologue, , v. 17, 01 mar. 2008.

• ESCARGUEIL, Alexandre Emmanuel . Mise en avant des interconnexions existantes entre microenvironnement et tumeur favorisant l?angiogénèse tumorale. La lettre du Cancérologue, 01 mar. 2008.

• ESCARGUEIL, Alexandre Emmanuel . L?angiostatine inhibe la migration des monocytes/macrophages via la disruption des filaments d?actine. La lettre du Cancérologue, 01 mar. 2008.

• ESCARGUEIL, Alexandre Emmanuel . L?implication des gènes de la famille ID dans la réinitiation tumorale liée à la formation de métastases pulmonaires initiées par des cellules de cancer du sein. La lettre du Cancérologue, 01 mar. 2008.

• ESCARGUEIL, Alexandre Emmanuel . Débat sur comment évaluer et approuver les tests génétiques. La lettre du Cancérologue, , v. 16, 01 mar. 2007.

• ESCARGUEIL, Alexandre Emmanuel . Lorsque la pression influe sur l?adhésion des cellules du cancer du côlon via la voie PI3K/Akt. La lettre du Cancérologue, , v. 16, 01 mar. 2007.

• ESCARGUEIL, Alexandre Emmanuel . Structures des mutants de l?EGFR caractéristiques du cancer du poumon : interaction avec ses inhibiteurs. La lettre du Cancérologue, , v. 16, 01 mar. 2007.

• LARSEN, Annette K ; SOARES, Daniele Grazziotin ; ESCARGUEIL, Alexandre Emmanuel ; POINDESSOUS, Virginie ; ROCCA, Celine ; KOEPPEL, F ; SARASIN, Alain ; HENRIQUES, João Antonio Pegas . Lesion processing of novel antitumor alkylators: mechanism of action and use in response prediction. In: 29th Winter meeting of the EORTC-PAMM Group, 2008, Palermo. 29th Winter meeting of the EORTC-PAMM Group, 2008.

• ROCCA, Celine ; POINDESSOUS, V ; SOARES, Daniele Grazziotin ; ESCARGUEIL, Alexandre Emmanuel ; SARASIN, A ; HICKMAN, J ; LÉONCE, S ; PIERRÉ, A ; LARSEN, Annette K . Deficiency of the BRCA2 tumor suppressor and homologous recombination is accompanied by increased sensitivity to the monofunctional alkylator S23906. In: 29th Winter meeting of the EORTC-PAMM Group, 2008, Palermo. 29th Winter meeting of the EORTC-PAMM Group, 2008.

• ESCARGUEIL, Alexandre Emmanuel . Irofulven as a new tool to study Transcription Coupled Repair in living mammalian cells. In: III Meeting in Fundamental Aspects of DNA Repair and Mutagenesis, 2007, São Paulo. III Meeting in Fundamental Aspects of DNA Repair and Mutagenesis, 2007.

• ROCCA, Celine ; POINDESSOUS, V ; SOARES, Daniele Grazziotin ; ESCARGUEIL, Alexandre Emmanuel ; SARASIN, Alain ; HICKMAN, J ; LÉONCE, S ; PIERRÉ, A ; LARSEN, Annette K . The minor-groove alkylator S23906 induces double-strand breaks that are repaired by homologous recombination. In: 28th Winter meeting of the EORTC-PAMM Group, Berlin, Germany, 2007, Berlin. Targeted Oncology, 2007. v. 2. p. 53S.

• Pencreach e ; ESCARGUEIL, Alexandre Emmanuel ; KEDINGER M ; GUERIN E ; GAUB M . Etude de l'effet de la pifithrin-alpha sur la prolifération et l'induction de la mort cellulaire après traitement par le CPT-11 dans un modèle de lignée de cancer du colon. In: 3émes journées francophones de Pathologie Digestive, Société Nationale Française de Gastroentérologie, 2007, Lyon. 3émes journées francophones de Pathologie Digestive, Société Nationale Française de Gastroentérologie, 2007.

• SOARES, Daniele Grazziotin ; ESCARGUEIL, Alexandre Emmanuel ; POINDESSOUS, V ; de Gramont, A. ; SARASIN, A ; BONATTO, Diego ; HENRIQUES, João Antonio Pegas ; LARSEN, Annette K . Replication and homologous recombination repair regulate DNA double strand break formation by the antitumor alkylator ecteinascidin 743. In: III Meeting in Fundamental Aspects of DNA Repair and Mutagenesis, 2007, São Paulo. III Meeting in Fundamental Aspects of DNA Repair and Mutagenesis, 2007.

• Sousa, Fabrício Garmus ; Matuo, Renata ; Grivicich, Ivana ; Zamin l ; Lenz G ; Escargueil, Alexandre E ; Henriques, João Antonio Pêgas ; Saffi, Jenifer . p38MAPK-dependent anti-mutagenesis and citotoxicity induced by Agaricus blazei beta-glucan. In: VIII Congresso da SBMCTA, 2007, Angra dos Reis. Brazilian Journal of Toxicology, 2007. v. 20. p. 72.

• ESCARGUEIL, Alexandre Emmanuel ; POINDESSOUS, V ; ROCCA, C ; SARASIN, A ; PIERRÉ, A ; LARSEN, A K . Nucleotide excision repair plays a major role in the sensitivity to S23906, a novel minor groove alkylating agent in clinical development. In: 27th Winter meeting of the EORTC-PAMM Group, 2006, Edimburgo, 2006.

• ESCARGUEIL, Alexandre Emmanuel . RNA Polymerase II as a modulator of Irofulven cytotoxicity. In: 27th Winter meeting of the EORTC-Pharmacology And Molecular Mechanisms Group, 2006, Edimburgo. 27th Winter meeting of the EORTC-Pharmacology And Molecular Mechanisms Group, 2006.

• POINDESSOUS, Virginie ; ROCCA, Celine ; SOARES, Daniele Grazziotin ; ESCARGUEIL, Alexandre Emmanuel . The cytotoxic activity of the monofunctional alkylator S23906 is mediated by generation of DNA double strand breaks that are repaired by homologous recombination in mammalian cells. In: 18th EORTC-NCI-AACR Symposium on "Molecular Targets and Cancer Therapeutics", 2006, Prague. European Journal of Cancer Supplements, 2006. v. 4. p. 91.

• ESCARGUEIL, Alexandre Emmanuel ; SKLADANOWSKI, A ; COME, M G ; SABISZ, M ; LARSEN, Ak . Specific downregulation of the mitotic regulator DNA topoisomerase IIalpha in vincristine-resistant cells leads to prolonged G2 transit and increased survival to microtubule-interacting agents. In: 26th Winter meeting of the EORTC-PAMM Group, 2005, Arcachon, 2005.

• SKLADANOWSKI, A ; COME, M G ; SABISZ, M ; ESCARGUEIL, Alexandre Emmanuel ; LARSEN, Ak . Topoisomerase IIalpha directly influence the cellular resistance to microtubule-interacting agents. In: 17th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, 2005, Filadelfia. Clinical Cancer Research Supplements, 2005. v. 11. p. 9174.

• POINDESSOUS, V ; ROCCA, C ; ESCARGUEIL, Alexandre Emmanuel ; SARASIN, A ; LÉONCE, S ; PIERRE, A ; LARSEN, A K . Marked sensitivity of Nucleotide Excision Repair-deficient cells to the novel minor groove binder S23906. In: 17th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, 2005, Filadelfia. Clinical Cancer Research Supplements, 2005. v. 11. p. 9016.

• ESCARGUEIL, Alexandre Emmanuel . Irofulven, a novel alkylating agent with an unique DNA repair and resistance profile. In: 26th Winter meeting of the EORTC-Pharmacology And Molecular Mechanisms Group, 2005, Arcachon. 26th Winter meeting of the EORTC-Pharmacology And Molecular Mechanisms Group, 2005.

• KOEPPEL, F ; ANNEREAU, J P ; ESCARGUEIL, Alexandre Emmanuel ; LEVAIQUE, H ; POINDESSOUS, V ; SZAKACS, G ; RAYMOND, e ; LAAR, e S Van ; WATERS, S J ; GOTTESMAN, M ; LARSEN, A K . Acquired irofulven-resistance is mediated by a novel and drug-specific resistance mechanism associated with overexpression of ABCA12. In: 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, 2004, Geneva. European Journal of Cancer Supplements, 2004. v. 2. p. 190.

• ESCARGUEIL, Alexandre Emmanuel ; IBORRA, F J ; KWEK, K Y ; AKOULITCHEV, A ; COOK, P R . Inter-connexion moléculaire des machineries de transcription, traduction et de détection des ARNs non correctement transcrits. In: Colloque du Groupe Thématique Interaction Acides Nucléiques-Protéines et expression du génome, Société Française de Biochimie et Biologie Moléculaire, 2003, Figeac. Colloque du Groupe Thématique Interaction Acides Nucléiques-Protéines et expression du génome, Société Française de Biochimie et Biologie Moléculaire, 2003.

• ESCARGUEIL, Alexandre Emmanuel ; IBORRA, F J ; COOK, P R . Trascription factories and the rediscovery of an old nuclear function - translation. In: Conférences Jacques-Monod Non coding RNAs : function in translation and regulation of genes expression, 2003, Aussois, 2003.

• ESCARGUEIL, Alexandre Emmanuel ; PLISOV, S Y ; SKLADANOWSKI, A ; BORGNE, A ; MEIJER, L ; GORBSKY, Gj ; LARSEN., A K . Nuclear recruitment of cdc2 kinase (CDK1) by DNA topoisomerase II is coupled to chromatin remodeling. In: Annual meeting of American Association for Cancer Research, 2002, San Francisco. Proceedings of the American Association for Cancer Research, 2002. v. 43. p. 160.

• LARSEN, A K ; LEMKE, K ; OESTERGAARD, V ; ANDERSEN, A H ; VEKRIS, A ; HAAZ, M C ; ROBERT, J ; ESCARGUEIL, Alexandre Emmanuel ; SKLADANOWSKI, A . Topoisomerases and transcriptional regulation. In: EORTC-NCI-AACR symposium on Molecular Targets and Cancer Therapeutics, 2002, Frankfurt. European Journal of Cancer Supplements, 2002. v. 38. p. 71.

• ESCARGUEIL, Alexandre Emmanuel ; PLISOV, S Y ; SKLADANOWSKI, A ; BORGNE, A ; MEIJER, L ; GORBSKY, G J ; LARSEN, Ak . Le recrutement de la protéine kinase mitotique cdc2 par l'ADN topoisomérase II est couplé à la restructuration de la chromatine. In: Colloque du Groupe Thématique Interaction Acides Nucléiques-Protéines et expression du génome, Société Française de Biochimie et Biologie Moléculaire, 2001, Figeac. Colloque du Groupe Thématique Interaction Acides Nucléiques-Protéines et expression du génome, Société Française de Biochimie et Biologie Moléculaire, 2001.

• ESCARGUEIL, Alexandre Emmanuel ; PLISOV, S Y ; SKLADANOWSKI, A ; BORGNE, A ; MEIJER, L ; GORBSKY, G J ; LARSEN, A K . Targeting of cdc2 kinase to DNA is mediated by DNA topoisomerase II alpha and is accompanied by chromatin remodeling.. In: Gordon's Research Conference, 2000, Oxford. Gordon's Research Conference, 2000.

• ESCARGUEIL, Alexandre Emmanuel ; SCALA, D ; ROSILIO, V ; COULAUD, D ; DELAIN, e ; RAYMOND, e ; INGBER, D ; SKLADANOWSKI, A ; NICKERSON, J ; LARSEN, A K . Le nucléosquelette: une nouvelle cible pour les médicaments anticancéreux. In: XXème Forum de Cancérologie, 2000, Paris, 2000.

• ESCARGUEIL, Alexandre Emmanuel ; LARSEN, A K ; PLISOV, S Y ; SCALA, D ; BORGNE, A ; MEIJER, L ; GORBSKY, G J . Cdc2 kinase regulates DNA topoisomerase II by physical contact, not by phosphorylation: a novel property of cyclin-dependent kinases. In: ISREC Meeting on the Cell cycle and Cancer, 1999, Lausanne, 1999.

• ESCARGUEIL, Alexandre Emmanuel ; PLISOV, S Y ; SCALA, D ; BORGNE, A ; MEIJER, L ; GORBSKY, G J ; LARSEN, A K . Formation of molecular complexes between DNA-topoisomerase II and p34cdc2-cyclin B stimulates topoisomerase II activities independent of phosphorylation. In: Annual meeting of American Association for Cancer Research, 1998, New Orleans. Proceedings of the American Association for Cancer Research, 1998. v. 39. p. 574.

• ESCARGUEIL, Alexandre Emmanuel ; PLISOV, S Y ; SCALA, D ; BORGNE, A ; MEIJER, L ; GORBSKY, G J ; LARSEN, A K . La formation du complexe moléculaire entre l'ADN-topoisomérase II et la p34cdc2-cycline B stimule l'activité catalytique de la topoisomérase II indépendamment de sa phosphorylation. In: Colloque du groupe thématique Phosphorylation des protéines, Société Française de Biochimie et Biologie Moléculaire, 1998, Arcachon. Colloque du groupe thématique Phosphorylation des protéines, Société Française de Biochimie et Biologie Moléculaire, 1998.

• ESCARGUEIL, Alexandre Emmanuel ; PLISOV, S Y ; SCALA, D ; BORGNE, A ; MEIJER, L ; GORBSKY, G J ; LARSEN, A K . The activity of DNA-topoisomerase II is stimulated by association with the mitotic kinase CDK1 (p34cdc2-cyclin B). In: The eight Conference on DNA Topoisomerases in Therapy, 1997, Amsterdam. The eight Conference on DNA Topoisomerases in Therapy, 1997.

Projetos de pesquisa

• 2004 - Atual

  Caracterização de novos medicamentos anticâncer, Descrição: Este estudo visa caracterisar os efeitos transcripcionais do agente anticâncer Irofulven. Este novo composto, desenvolvido pelo grupo farmacêutico MGI Pharma, é um agente alquilante capaz de induzir lesões no DNA. Contrariarmente a outros agentes alquilantes, como por exemplo cisplatina, as lesões induzidas por este copmposto são unicamente e especificamente reconhecidas e reparadas pelo sistema de reparação acoplado à transcrição (Transcription Coupled Nucleotide Excision Repair, TC-NER). Recentemente, nos mostramos que este composto é capaz de inibir especificamente a transcrição ligada a atividade de RNA polimerase II e não daquelas ligadas as atividades das RNAs polimerases I e III. Em vista disto, este composto constitui uma importante ferramenta para estudar os processos de reparação e sua ligação com os mecanismos de transcrição ligados com a atividade da RNA polimerase II. Ainda, este projeto deve permitir de melhorar a compreensão dos mecanismos de citotoxicidade deste novo medicamento antitumoral.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (0) / Especialização: (0) / Mestrado acadêmico: (0) / Mestrado profissional: (0) / Doutorado: (0) . , Integrantes: Alexandre Emmanuel Escargueil - Integrante / Annette K Larsen - Coordenador / Virginie Poindessous - Integrante., Financiador(es): Ipsen Beaufour - Remuneração.

• 2001 - 2004

  Transcrição e Tradução Nuclear, Descrição: Este projeto teve como objetivo identificar as diversas substâncias associadas ao RNA em curso de sintese e, em particular, melhor compreender os processos de tradução de RNA que se desenvolvem no nucleo. Em um artigo publicado na J. Cell Sci. em 2004, nos mostramos a associação das maquinarias de transcrição, de tradução, mas também de degradação de RNA não corretamente transcritos ("non-sense mediated mRNA decay") no interior do nucleo de células de mamiferos. Esta tematica original teve por ambição apresentar uma nova visão da associação entre os processos necessarios a fidelidade da transcrição de genes e sua organisação no nucleo da célula.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (0) / Especialização: (0) / Mestrado acadêmico: (0) / Mestrado profissional: (0) / Doutorado: (0) . , Integrantes: Alexandre Emmanuel Escargueil - Integrante / Peter R Cook - Coordenador., Financiador(es): Federation Of European Biochemical Societies - Remuneração.

• 2000 - 2001

  Transportadores de Membrana e Resistência Celular, Descrição: A P-glicopreoteina é um transportador do tipo ""ATP-Binding Cassette", presente na membrana citoplasmica, responsavel pelo fenotipo de multi-resistência as drogas. Esta proteina catalisa, de maneira ATP-dependente o transporte de numerosos compostos. Contudo, em ausência de substrato, a P-glicoproteina apresenta uma atividade basal de hidrolise de ATP. Neste sentido, em um artigo publicado na Proc. Natl. Acad. Sci. em 2002, nos mostramos que esta atividade basal esta associada à translocação do colesterol entre os folhetos internos e externos da membrana citoplasmica ao nivel de estruturas membranarias chamadas "caveolae", as quais a P-glicoproteina esta associada e que contém diversos elementos de sinalização celular implicados na endocitose, transcitose e cancerogênese.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (0) / Especialização: (0) / Mestrado acadêmico: (0) / Mestrado profissional: (0) / Doutorado: (0) . , Integrantes: Alexandre Emmanuel Escargueil - Coordenador / Stéphane Orlowski - Integrante., Financiador(es): Ministere Des Armées - Remuneração.

• 1996 - 2000

  Função e Regulação da DNA Topoisomerase II alpha nas fases precoces da mitose., Descrição: Os inibidores de topoisomerases são potentes indutores de quebras no DNA e são um dos grupos de agentes mais amplamente utilisados na clinica. Danos no DNA e a ausência da atividade de top II vão induzir fatores que promovem o bloqueio das células em fase G2 do ciclo celular. Este bloqueio é principlamente controlado via ativação da quinase mitotica principal cdc2. Nesta situação de dano, mesmo quando a mitose esta iniciada em sua fase precoce, a célula continua capaz de ativar os pontos de controle e de bloquear seu ciclo celular a fim de reparar as eventuais lesões desenvolvidas. A top II alpha apresenta um papel crucial no curso da mitose participando dos processos de condensação de cromossomos e de segregação de cromatides irmãs. A fim de melhor esclarecer seu papel no controle da transição G2/M, nos procuramos entender as funções e regulações desta enzima no curso das fases precoces da mitose. Este trabalho mostrou a interaçao direta entre a topoisomerase II alpha e a quinase mitotica cdc2. Esta interação, descrita no artigo publicado no The FASEB J. em 2001, é capaz de induzir um aumento da capacidade da top II alpha de ligar de maneira covalente ao DNA e é também responsavel por selecionar o alvo da quinase cdc2 nos cromossomos. Paralelamente, em um artigo publicado na J. Biol. Chem. em 2000 nos identificamos os residuos e a proteina quinase (CK2) responsaveis pela formação do fosfo-epitope MPM-2 na top II alpha. A possivel associação da topoisomerase II alpha com o peptideo peptidil-prolil-isomerase Pin1 (proteina implicada no controle da transição G2/M) depende da fosforilaçao deste residuo. Estes resultados mostraram que além de ser a causa de danos no DNA e de induzir pontos de controle do ciclo celular, a top II alpha participa também diretamente no controle da entrada das células em mitose. Através da sua interação com as proteinas cdc2 e Pin1 ela participa na modulação das fases precoces da mitose e na sua reversão em casos de danos.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (0) / Especialização: (0) / Mestrado acadêmico: (0) / Mestrado profissional: (0) / Doutorado: (0) . , Integrantes: Alexandre Emmanuel Escargueil - Integrante / Annette K Larsen - Coordenador., Financiador(es): Ministere de l Education Superieure Et de La Recherche - Remuneração.

Prêmios