Soledad Marton Garcia

Possui doutorado em Bioquímica y Biologia Molecular - Insti de Parasitología y Biomedicina ´López-Neyra (2012). Tem experiência na área de Bioquímica, com ênfase em Biologia Molecular My work has focused on RNA biology. My PhD research was centered on the study of hepatitis C virus (HCV) cis acting replication element (CRE), located in the 3 end coding region of the genomic RNA. We did an in vitro selection method (SELEX), to select RNA aptamers that bind to the HCV-CRE. Our results show that RNA aptamers could be used as molecular tools for studying essential genomic element and highlight the potential of CRE as a target for the development of anti-HCV therapies. For my master studies at the Institut Pasteur in Montevideo, I studied differences in microRNA expression profile between CLL (Chronic Lymphocytic Leukemia) patients and controls by cloning small RNAs. Both experiences allowed me to dominate molecular biology techniques, cell culture, and interpret and analyze results and at the same time develop a critical spirit.

Informações coletadas do Lattes em 10/11/2022

Acadêmico

Formação acadêmica

Doutorado em Bioquímica y Biologia Molecular

2008 - 2012

Insti de Parasitología y Biomedicina "López-Neyra
Título: Selección y caracterización de RNAs dirigidos contra el dominio genómico CRE del virus de la hepatitis C (HCV)
Orientador: Alfredo Berzal-Herranz
Bolsista do(a): Agência Espanhola de Cooperação Internacional. Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular. Setores de atividade: Pesquisa e desenvolvimento científico.

Mestrado em Msc Molecular and Cellular Biology

2005 - 2008

Instituto Pasteur-Montevideo
Orientador: Alfonso Cayota
Bolsista do(a): Agencia Nacional de Investigación e Innovación. Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular. Grande Área: Ciências Biológicas / Área: Biologia Geral. Setores de atividade: Pesquisa e desenvolvimento científico.

Graduação em Biochemistry

1998 - 2005

Universidad de la Republica Uruguay

Idiomas

Inglês

Compreende Razoavelmente, Fala Razoavelmente, Lê Razoavelmente, Escreve Razoavelmente.

Espanhol

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Português

Compreende Razoavelmente, Fala Razoavelmente, Lê Razoavelmente, Escreve Razoavelmente.

Áreas de atuação

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.

Participação em eventos

V Meeting of RNA Spanish Network. Valencia, Spain.. RNA aptamers directed against genomic hepatitis C virus CRE domain .. 2012. (Encontro).

XI Congreso Nacional de Virología.. Characterization of the Hepatitis C Virus genomic domain, CRE, as a potential therapeutic target . 2011. (Congresso).

4th European Congress of Virology.. A long-range RNA-RNA interaction between the 5 and the 3 ends of the hepatitis C virus genome .. 2010. (Congresso).

4th Nucleic Acid Chemical Biology (NACB) PhD Summer School.. Isolation and characterization of inhibitor RNAs directed against conserved regions of hepatitis C virus, HCV. . 2009. (Outra).

XII Conference of the Uruguayan Biosciences Society.. Cloning-based analysis of small RNAs in B-lymphocytes from patients with Chronic Lymphocytic Leukemia .. 2007. (Oficina).

International Workshop on Chronic Lymphocytic Leukemia.. CLL cells significantly underexpress miRNAs 181a, 30d and let-7a and differentially express a set of miRNA genes according to prognostic molecular markers .. 2007. (Oficina).

71st Cold Spring Harbor Symposia: Regulatory RNAs.. Cloning-based analysis of small RNAs in B lymphocytes from patients with chronic lymphocytic leukemia .. 2006. (Simpósio).

V meeting of biochemistry and molecular biology.. Small RNA expression in B lymphocyte of Chronic lymphocytic leukemia patients .. 2006. (Encontro).

International symposium on myosin V.. Sorting of axonal RNPs by molecular motors :. 2004. (Simpósio).

2nds meeting of biochemistry and molecular biology.Localización de diferentes componentes de ribonucleopartículas en las placas ribosomales periaxoplásmicas de axones mielínicos. 2003. (Encontro).

Produções bibliográficas

Marton, S. ; Romero-López, C. ; Berzal-Herranz, A. . RNA aptamer-mediated interference of HCV replication by targeting the CRE-5BSL3.2 domain. Journal of Viral Hepatitis (Print) , v. 20, p. 103-112, 2013.
2012 Marton, Soledad ; Berzal-Herranz, Beatriz ; Garmendia, Eva ; Berzal-Herranz, Alfredo . Anti-HCV RNA Aptamers Targeting the Genomic cis-Acting Replication Element. Pharmaceuticals , v. 5, p. 49-60, 2012.
2010 Marton, Soledad ; Reyes-Darias, José A. ; Sánchez-Luque, Francisco J. ; Romero-López, Cristina ; Berzal-Herranz, Alfredo . In Vitro and Ex Vivo Selection Procedures for Identifying Potentially Therapeutic DNA and RNA Molecules. Molecules (Basel. Online) , v. 15, p. 4610-4638, 2010.
2007 Marton, S ; Garcia, M R ; Robello, C ; Persson, H ; Trajtenberg, F ; Pritsch, O ; Rovira, C ; Naya, H ; Dighiero, G ; Cayota, A . Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. Leukemia , v. 22, p. 330-338, 2007.

Histórico profissional

Endereço profissional

Fundação Oswaldo Cruz. , Rua Professor Algacyr Munhoz Mader - de 2891/2892 ao fim, Cidade Industrial, 81350010 - Curitiba, PR - Brasil, Telefone: (41) 33163230

Experiência profissional

2008 - 2012

AGENCIA ESPAÑOLA DE COOPERACIÓN INTERNACIONAL

Vínculo: Scholarship, Enquadramento Funcional: PhD research, Regime: Dedicação exclusiva.

2007 - 2007

Universidad de la Republica Uruguay

Vínculo: , Enquadramento Funcional: Professor in Biochemistry practical courses, Carga horária: 20

Outras informações:
Preparation of laboratory equipment for practical courses, to explain to students the activities and correct the student informs.