Friederike Klempin

Pós-doutorado

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Áreas de atuação

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Orientou

Produções bibliográficas

• PETERMANN, MARKUS ; KRONENBERG, GOLO ; MOSIENKO, VALENTINA ; BADER, MICHAEL ; ALENINA, NATALIA ; HELLWEG, RAINER ; KLEMPIN, FRIEDERIKE . Alterations in BDNF Protein Concentrations in the Hippocampus do not Explain the Pro-Neurogenic Effect of Citalopram on Adult Neurogenesis. PHARMACOPSYCHIATRY , v. 54, p. 101-105, 2021.

• TURKIN, ANDREI ; TUCHINA, OKSANA ; KLEMPIN, FRIEDERIKE . Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY , v. 9, p. 39-43, 2021.

• CHIARELI, RAPHAELA ALMEIDA ; CARVALHO, GUSTAVO ALMEIDA ; MARQUES, BRUNO LEMES ; MOTA, LENNIA SOARES ; OLIVEIRA-LIMA, ONÉSIA CRISTINA ; GOMES, RODRIGO MELLO ; BIRBRAIR, ALEXANDER ; GOMEZ, RENATO SANTIAGO ; SIMÃO, FABRÍCIO ; KLEMPIN, FRIEDERIKE ; LEIST, MARCEL ; PINTO, MAURO CUNHA XAVIER . The Role of Astrocytes in the Neurorepair Process. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY , v. 9, p. 95-102, 2021.

• KLEMPIN, FRIEDERIKE ; SIMÃO, FABRICIO ; CUNHA XAVIER PINTO, MAURO . Editorial: Neurorepair Strategies to Induce Angiogenesis, Neurogenesis and Synaptic Plasticity. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY , v. 9, p. 81-82, 2021.

• SIDOROVA, MARIA ; KRONENBERG, GOLO ; MATTHES, SUSANN ; PETERMANN, MARKUS ; HELLWEG, RAINER ; TUCHINA, OKSANA ; BADER, MICHAEL ; ALENINA, NATALIA ; KLEMPIN, FRIEDERIKE . Enduring Effects of Conditional Brain Serotonin Knockdown, Followed by Recovery, on Adult Rat Neurogenesis and Behavior. Cells , v. 10, p. 3240, 2021.

• MARQUES, BRUNO LEMES ; OLIVEIRA-LIMA, ONÉSIA CRISTINA ; CARVALHO, GUSTAVO ALMEIDA ; DE ALMEIDA CHIARELLI, RAPHAELA ; RIBEIRO, RAUL IZIDORO ; PARREIRA, RICARDO CAMBRAIA ; DA MADEIRA FREITAS, ELIS MARRA ; RESENDE, RODRIGO RIBEIRO ; KLEMPIN, FRIEDERIKE ; ULRICH, HENNING ; GOMEZ, RENATO SANTIAGO ; PINTO, MAURO CUNHA XAVIER . Neurobiology of glycine transporters: From molecules to behavior. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS , v. 118, p. 97-110, 2020.

• KRONENBERG, GOLO ; KLEMPIN, FRIEDERIKE . Laying out the evidence for the persistence of neurogenesis in the adult human hippocampus. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE , v. 1, p. 2, 2019.

• VAN LINGEN, MARIKE ; SIDOROVA, MARIA ; ALENINA, NATALIA ; KLEMPIN, FRIEDERIKE . Lack of Brain Serotonin Affects Feeding and Differentiation of Newborn Cells in the Adult Hypothalamus. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY , v. 7, p. 65-69, 2019.

• KRONENBERG, GOLO ; UHLEMANN, RIA ; RICHTER, NADINE ; KLEMPIN, FRIEDERIKE ; WEGNER, STEPHANIE ; STAERCK, LILIAN ; WOLF, SUSANNE ; UCKERT, WOLFGANG ; KETTENMANN, HELMUT ; ENDRES, MATTHIAS ; GERTZ, KAREN . Distinguishing features of microglia- and monocyte-derived macrophages after stroke. ACTA NEUROPATHOLOGICA , v. 135, p. 551-568, 2018.

• BRACKE, A. ; SCHÄFER, S. ; VON BOHLEN UND HALBACH, V. ; KLEMPIN, F. ; BENTE, K. ; BRACKE, K. ; STAAR, D. ; VAN DEN BRANDT, J. ; HARZSCH, S. ; BADER, M. ; WENZEL, U. O. ; PETERS, J. ; VON BOHLEN UND HALBACH, O. . ATP6AP2 over-expression causes morphological alterations in the hippocampus and in hippocampus-related behaviour. Brain Structure & Function , v. 223, p. 2287-2302, 2018.

• KLEMPIN, F. ; MOSIENKO, VALENTINA ; Matthes S ; Villela DC ; Todiras M ; JM, P.Penninger JM ; BADER, MICHAEL ; ALENINA, NATALIA . Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response. CELLULAR AND MOLECULAR LIFE SCIENCES , p. 3625-363, 2018.

• WASINSKI, FREDERICK ; BATISTA, ROGERIO OLIVEIRA ; BADER, MICHAEL ; ARAUJO, RONALDO C. ; KLEMPIN, FRIEDERIKE . Bradykinin B2 receptor is essential to running-induced cell proliferation in the adult mouse hippocampus. Brain Structure & Function , v. 9, p. xxx, 2018.

• KRONENBERG, GOLO ; PETERMANN, MARKUS ; DORMANN, CHRISTOF ; BADER, MICHAEL ; GASS, PETER ; HELLWEG, RAINER ; KLEMPIN, FRIEDERIKE . Brain serotonin critically contributes to the biological effects of electroconvulsive seizures. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE , v. 268, p. 861-864, 2018.

• KLEMPIN, FRIEDERIKE ; GERTZ, KAREN ; KRONENBERG, GOLO . Redox homeostasis: unlocking the bottleneck in glia-to-neuron conversion. Stem Cell Investigation , v. 4, p. 7-7, 2017.

• KRONENBERG, GOLO ; MOSIENKO, VALENTINA ; GERTZ, KAREN ; ALENINA, NATALIA ; HELLWEG, RAINER ; KLEMPIN, FRIEDERIKE . Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE , v. 266, p. 281-284, 2016.

• WASINSKI, FREDERICK ; ESTRELA, GABRIEL R. ; ARAKAKI, ALINE M. ; BADER, MICHAEL ; ALENINA, NATALIA ; KLEMPIN, FRIEDERIKE ; ARAÚJO, RONALDO C. . Maternal Forced Swimming Reduces Cell Proliferation in the Postnatal Dentate Gyrus of Mouse Offspring. Frontiers in Neuroscience , v. 10, p. 402, 2016.

• NOTO, BETTINA ; KLEMPIN, FRIEDERIKE ; ALENINA, NATALIA ; BADER, MICHAEL ; FINK, HEIDRUN ; SANDER, SVENJA E. . Increased adult neurogenesis in mice with a permanent overexpression of the postsynaptic 5-HT 1A receptor. NEUROSCIENCE LETTERS , v. 633, p. 246-251, 2016.

• ALENINA, NATALIA ; KLEMPIN, FRIEDERIKE . The role of serotonin in adult hippocampal neurogenesis. BEHAVIOURAL BRAIN RESEARCH , v. 277, p. 49-57, 2015.

• WASINSKI, FREDERICK ; BACURAU, REURY FRANK PEREIRA ; ESTRELA, GABRIEL RUFINO ; KLEMPIN, FRIEDERIKE ; ARAKAKI, ALINE MIDORI ; BATISTA, ROGERIO OLIVEIRA ; MAFRA, FERNANDO FRANCISCO PAZELLO ; DO NASCIMENTO, LUCAS FRANCISCO RIBEIRO ; HIYANE, MEIRE IOSHIE ; VELLOSO, LÍCIO AUGUSTO ; CÂMARA, NIELS OLSEN SARAIVA ; ARAUJO, RONALDO CARVALHO . Exercise during pregnancy protects adult mouse offspring from diet-induced obesity. Nutrition & Metabolism , v. 12, p. 402, 2015.

• NARBOUX-NÊME, NICOLAS ; ANGENARD, GAELLE ; MOSIENKO, VALENTINA ; KLEMPIN, FRIEDERIKE ; PITYCHOUTIS, POTHITOS M. ; DENERIS, EVAN ; BADER, MICHAEL ; GIROS, BRUNO ; ALENINA, NATALIA ; GASPAR, PATRICIA . Postnatal Growth Defects in Mice with Constitutive Depletion of Central Serotonin. ACS Chemical Neuroscience , v. 4, p. 171-181, 2013.

• LAUTNER, R. Q. ; VILLELA, D. C. ; FRAGA-SILVA, R. A. ; SILVA, N. ; VERANO-BRAGA, T. ; COSTA-FRAGA, F. ; JANKOWSKI, J. ; JANKOWSKI, V. ; SOUSA, F. ; ALZAMORA, A. ; SOARES, E. ; BARBOSA, C. ; KJELDSEN, F. ; OLIVEIRA, A. ; BRAGA, J. ; SAVERGNINI, S. ; MAIA, G. ; PELUSO, A. B. ; PASSOS-SILVA, D. ; KLEMPIN, F. . Discovery and Characterization of Alamandine: A Novel Component of the Renin-Angiotensin System. CIRCULATION RESEARCH , v. 112, p. 1104-1111, 2013.

• RAMIREZ-RODRIGUEZ, G. ; BABU, H. ; KLEMPIN, F. ; KRYLYSHKINA, O. ; BAEKELANDT, V. ; GIJSBERS, R. ; DEBYSER, Z. ; OVERALL, R. W. ; NICOLA, Z. ; FABEL, K. ; KEMPERMANN, G. . The   Crystallin Domain of Small Heat Shock Protein b8 (Hspb8) Acts as Survival and Differentiation Factor in Adult Hippocampal Neurogenesis. JOURNAL OF NEUROSCIENCE , v. 33, p. 5785-5796, 2013.

• KLEMPIN, F. ; BEIS, D. ; MOSIENKO, V. ; KEMPERMANN, G. ; BADER, M. ; ALENINA, N. . Serotonin Is Required for Exercise-Induced Adult Hippocampal Neurogenesis. JOURNAL OF NEUROSCIENCE , v. 33, p. 8270-8275, 2013.

• KLEMPIN, FRIEDERIKE ; MARR, ROBERT A. ; PETERSON, DANIEL A. . Modification of Pax6 and Olig2 Expression in Adult Hippocampal Neurogenesis Selectively Induces Stem Cell Fate and Alters Both Neuronal and Glial Populations. STEM CELLS , v. 30, p. 500-509, 2012.

• EHNINGER, DAN ; WANG, LI-PING ; KLEMPIN, FRIEDERIKE ; RÖMER, BENEDIKT ; KETTENMANN, HELMUT ; KEMPERMANN, GERD . Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice. CELL AND TISSUE RESEARCH , v. 345, p. 69-86, 2011.

• KLEMPIN, FRIEDERIKE ; KRONENBERG, GOLO ; CHEUNG, GISELLE ; KETTENMANN, HELMUT ; KEMPERMANN, GERD . Properties of Doublecortin-(DCX)-Expressing Cells in the Piriform Cortex Compared to the Neurogenic Dentate Gyrus of Adult Mice. PLoS One , v. 6, p. e25760, 2011.

• Klempin . Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis. Frontiers in Molecular Neuroscience , v. 3, p. xxx, 2010.

• RAMÍREZ-RODRÍGUEZ, GERARDO ; KLEMPIN, FRIEDERIKE ; BABU, HARISH ; BENÍTEZ-KING, GLORIA ; KEMPERMANN, GERD . Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice. NEUROPSYCHOPHARMACOLOGY , v. 34, p. 2180-2191, 2009.

• STEINER, BARBARA ; KUPSCH, ANDREAS ; SIEBERT, EBERHARD ; HOSMANN, KAI ; KLEMPIN, FRIEDERIKE ; MORGENSTERN, RUDOLF ; WINTER, CHRISTINE . Unilateral lesion of the subthalamic nucleus transiently provokes bilateral subacute glial cell proliferation in the adult rat substantia nigra. NEUROSCIENCE LETTERS , v. 430, p. 103-108, 2008.

• KLEMPIN, FRIEDERIKE ; KEMPERMANN, GERD . Adult hippocampal neurogenesis and aging. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (INTERNET) , v. 257, p. 271-280, 2007.

• STEINER, BARBARA ; KLEMPIN, FRIEDERIKE ; WANG, LIPING ; KOTT, MONIKA ; KETTENMANN, HELMUT ; KEMPERMANN, GERD . Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis. GLIA (ONLINE) , v. 54, p. 805-814, 2006.

• PLÜMPE, TOBIAS ; EHNINGER, DAN ; STEINER, BARBARA ; KLEMPIN, FRIEDERIKE ; JESSBERGER, SEBASTIAN ; BRANDT, MORITZ ; RÖMER, BENEDIKT ; RODRIGUEZ, GERARDO ; KRONENBERG, GOLO ; KEMPERMANN, GERD . Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation.. BMC NEUROSCIENCE , v. 7, p. 77, 2006.

• KLEMPIN, F. ; Horner, PJ ; Kaspar, B . Keystone, Winterconference on brain research. 2010. (Apresentação de Trabalho/Congresso).

Outras produções

Projetos de pesquisa

• 2017 - 2018

  Lack of brain serotonin affects feeding and differentiation of newborn cells in the adult hypothalamus, Descrição: Given the potential role of serotonin in energy balance (e.g. satiety), and altered energy expenditure in Tph2-/- mice, a direct approach is eminent. Here, we will investigate changes in food intake, and precursor cell proliferation and survival in the adult hypothalamus at baseline and following high cholesterol diet (HCD).. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (1) . , Integrantes: Friederike Klempin - Coordenador / Marike van Lingen - Integrante., Financiador(es): Berlin Institute of Health - Auxílio financeiro.

• 2017 - Atual

  The role of microglia cells in the pro-neurogenic effect of serotonin, Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: / Mestrado profissional: (1) / Doutorado: (1) . , Integrantes: Friederike Klempin - Coordenador / Andrei Turkin - Integrante / Oksana Tuchina - Integrante.

• 2014 - 2020

  Identifying the mechanisms of antidepressant drug action in mice lacking brain serotonin, Descrição: Major depression is a serious mental disorder, which affects up to 15% of the population. Pharmacological manipulation of serotonin (5-HT) leads to clinical improvement associated with a delayed increase in hippocampal neurogenesis. ?State of the art? therapy consists of selective serotonin reuptake inhibitors (SSRIs), however, not all patients respond to this treatment. Intriguingly, tianeptine, which acts as a selective serotonin reuptake enhancer (SSRE) is also a potent antidepressant and has therefore been called a ?hypothesis killer?. Here we propose that the lack of a clear mechanism for SSRI function significantly limits our ability to effectively manage depression. In this proposal we a) take advantage of our recent insights into the role of serotonin in activity-dependent neurogenesis, b) apply a powerful genetic model that lacks brain serotonin to test a variety of pro-, and antidepressive stimuli that will directly translate to the clinical situation, and c) explore the interplay of brain-derived neurotrophic factor (BDNF) and serotonin.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Friederike Klempin - Coordenador / Golo Kronenberg - Integrante / Markus Petermann - Integrante., Financiador(es): Berlin Institute of Health - Auxílio financeiro.

• 2014 - 2016

  Serotonergic mechanisms and therapeutic relevance of neuron (re)generation in the adult brain, Descrição: Today?s serotonin pharmacotherapy is based on treatment outcome that lacks a clear understanding of the underlying therapeutic mechanisms but also the pathways that produce counter-indications. Here, I propose new insights will come from pharmacologically targeting receptors in combination with a powerful imaging approach for the in vivo assessment of mechanism of serotonin action.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Friederike Klempin - Coordenador., Financiador(es): Deutsche Forschungsgemeinschaft - Auxílio financeiro.

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