Frederico Severino Martins

Formação complementar

Idiomas

Áreas de atuação

Participação em eventos

Participação em bancas

Orientou

Produções bibliográficas

• DE AGUIAR, ANTÔNIO SÉRGIO NAKAO ; DE CARVALHO, LUCAS BARBOSA RIBEIRO ; GOMES, CLAYSON MOURA ; CASTRO, MURILLO MORAES ; MARTINS, FREDERICO SEVERINO ; BORGES, LEONARDO LUIZ . Computational Insights into the Antioxidant Activity of Luteolin: Density Functional Theory Analysis and Docking in Cytochrome P450 17A1. PHARMACEUTICALS , v. 18, p. 410, 2025.

• LIMA, ERICA TIRZAH S. ; SANTOS, VICTORIA L. S. ; MOTA, WANESSA J. S. ; MARTINS, FREDERICO S. ; DE ALBUQUERQUE-JUNIOR, RICARDO L. C. ; SANTOS, ANDRÉ L. S. ; OLIVEIRA, SIMONE S. C. ; DE LIMA, JÉSSICA A. ; DE JESUS SANTOS, ADRIANA ; DOS SANTOS, COCHIRAN P. ; JAIN, SONA ; SOUTO, ELIANA B. ; CARDOSO, JULIANA C. ; SEVERINO, PATRÍCIA . Green Propolis Extract-Mediated Synthesis of Biogenic Silver Nanoparticles: In vitro Antileishmanial and Antibacterial Activities, Cytotoxicity and Ex vivo Irritation Testing. CHEMISTRY & BIODIVERSITY , v. 1, p. 1, 2025.

• MARTINS, FREDERICO SEVERINO ; KOLLIPARA, SIVACHARAN ; SIVADASU, PRAVEEN ; YU, MINGMING ; SEVERINO, PATRICIA ; SOUTO, ELIANA . The Innovation Paradox in Emerging Pharmaceutical Markets: Barriers and Opportunities for Sustainable Development. PHARMACEUTICAL RESEARCH , v. 2, p. 2, 2025.

• MACENTE, JULIA ; NAUWELAERTS, NINA ; BADÉE, JUSTINE MARINE ; BONAN, RODOLFO HERNANDES ; HUANG, MIAO'CHAN ; VAN NESTE, MARTJE ; SMITS, ANNE ; ALLEGAERT, KAREL ; NORDENG, HEDVIG ; HOVD, MARKUS ; MARTINS, FREDERICO SEVERINO ; ANNAERT, PIETER . Predicting Drug Transfer Into Human Milk With the Simcyp Simulator: A Contribution From the Project. Cpt-Pharmacometrics & Systems Pharmacology , v. 1, p. 1-15, 2025.

• KHAN, MOHAMMED SHAREEF ; KHAN, SOHEL MOHAMMED ; MARTINS, FREDERICO SEVERINO ; BODDU, RAJKUMAR ; SAINI, ANUJ KUMAR ; KOLLIPARA, SIVACHARAN . New Era in Bioequivalence Global Harmonization through ICH M13 Initiative: Critical Review on New Concepts, Alternative Approaches for High-Risk Products. XENOBIOTICA , v. 1, p. 1-23, 2025.

• KOLLIPARA, SIVACHARAN ; MARTINS, FREDERICO SEVERINO ; JEREB, REBEKA ; KRAJCAR, DEJAN ; AHMED, TAUSIF . Advancing Virtual Bioequivalence for Orally Administered Drug Products: Methodology, Real-World Applications and Future Outlook. PHARMACEUTICALS , v. 17, p. 876, 2024.

• AMARAL, VENÂNCIO A. ; SANTANA, VICTORIA L. ; LISBOA, ERIKA S. ; MARTINS, FREDRICO S. ; CHAUD, MARCO V. ; DE ALBUQUERQUE-JÚNIOR, RICARDO L. C. ; SANTANA, WANESSA ; SANTOS, COCHIRAN ; DE JESUS SANTOS, ADRIANA ; CARDOSO, JULIANA C. ; SOUTO, ELIANA B. ; SEVERINO, PATRÍCIA . Chitosan membranes incorporating Aloe vera glycolic extract with joint synthesis of silver nanoparticles for the treatment of skin lesions. Drug Delivery and Translational Research , v. 1, p. 1, 2024.

• WU, MENGYUAN ; FENG, KUN ; WU, XIAO ; LIU, CHANG ; ZHU, SHIXING ; MARTINS, FREDERICO S. ; YU, MINGMING ; LV, ZHIHUA ; YAN, MEIXING ; SY, SHERWIN K. B. . Prediction of tissue exposures of polymyxin-B, amikacin and sulbactam using physiologically-based pharmacokinetic modeling. Frontiers in Microbiology , v. 15, p. 1, 2024.

• GONZAGA, LUCAS WAMSER FONSECA ; EGITO, BEATRIZ MONTE ; COELHO, JOÃO BOSCO COSTA ; SOUZA, GABRIELA PEREIRA ; MARTINS, FREDERICO SEVERINO ; FERRANTE, MARCOS . Advances in Canine Anesthesia: Physiologically Based Pharmacokinetic Modeling for Predicting Propofol Plasma Profiles in Canines with Hepatic Impairment. PHARMACEUTICALS , v. 17, p. 1720, 2024.

• SCHALLER, STEPHAN ; MICHON, INGRID ; BAIER, VANESSA ; MARTINS, FREDERICO SEVERINO ; NOLAIN, PATRICK ; TANEJA, AMIT . Evaluation of BCRP-Related DDIs Between Methotrexate and Cyclosporin A Using Physiologically Based Pharmacokinetic Modelling. Drugs in R&D , v. 24, p. 1-17, 2024.

• BORGES, LEONARDO LUIZ ; MARTINS, FREDERICO SEVERINO ; FRANCO, JOÃO JOSÉ ; BAILÃO, ELISA FLÁVIA LUIZ CARDOSO ; CRUVINEL, WILSON DE MELO ; UYEMURA, SÉRGIO AKIRA ; CONCEIÇÃO, EDEMILSON CARDOSO DA . Effects of liquid extract from Plinia cauliflora fruits residues on Chinese hamsters biochemical parameters. BRAZILIAN JOURNAL OF BIOLOGY (ONLINE) , v. 83, p. 1, 2023.

• ZHANG, JIAYUAN ; WU, MENGYUAN ; DIAO, SHUO ; ZHU, SHIXING ; SONG, CHU ; YUE, JIALI ; MARTINS, FREDERICO S. ; ZHU, PEIJUAN ; LV, ZHIHUA ; ZHU, YUANQI ; YU, MINGMING ; SY, SHERWIN K. B. . Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing Escherichia coli and Klebsiella pneumoniae. PHARMACEUTICS , v. 15, p. 251, 2023.

• MACENTE, JULIA ; NAUWELAERTS, NINA ; RUSSO, FRANCESCA M. ; DEPREST, JAN ; ALLEGAERT, KAREL ; LAMMENS, BART ; HERNANDES BONAN, RODOLFO ; TURNER, JESSICA M. ; KUMAR, SAILESH ; DINIZ, ANDREA ; MARTINS, FREDERICO S. ; ANNAERT, PIETER . PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia. Frontiers in Pharmacology , v. 14, p. 1, 2023.

• MARTINS, FREDERICO SEVERINO ; MARTINS, JOSÉ EDUARDO SEVERINO ; SEVERINO, PATRICIA ; ANNAERT, PIETER ; SY, SHERWIN K. B. . Physiologically-based pharmacokinetic modeling to inform combination dosing regimens of ceftaroline and daptomycin in special populations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY , v. 1, p. 7, 2023.

• NAUWELAERTS, NINA ; MACENTE, JULIA ; DEFERM, NEEL ; BONAN, RODOLFO HERNANDES ; HUANG, MIAO-CHAN ; VAN NESTE, MARTJE ; BIBI, DAVID ; BADEE, JUSTINE ; MARTINS, FREDERICO S. ; SMITS, ANNE ; ALLEGAERT, KAREL ; BOUILLON, THOMAS ; ANNAERT, PIETER . Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling-A Contribution from the ConcePTION Project. PHARMACEUTICS , v. 15, p. 1469, 2023.

• Severino Martins, Frederico ; BORGES, LUIZA ; OLIVEIRA DO COUTO, RENE ; SCHALLER, STEPHAN ; DE FREITAS, OSVALDO . Integration of artificial neural network and physiologically based biopharmaceutic models in the development of sustained-release formulations. BIOPHARMACEUTICS & DRUG DISPOSITION , v. 1, p. 1, 2023.

• KOLLIPARA, SIVACHARAN ; MARTINS, FREDERICO ; SANGHAVI, MAITRI ; SANTOS, GUSTAVO MENDES LIMA ; SAINI, ANUJ ; AHMED, TAUSIF . Role of Physiologically Based Biopharmaceutics Modeling (PBBM) in Fed Bioequivalence Study Waivers: Regulatory Outlook, Case Studies and Future Perspectives. JOURNAL OF PHARMACEUTICAL SCIENCES , v. 1, p. 123, 2023.

• PATEL, NIKUNJKUMAR ; CLARKE, JAMES F. ; SALEM, FARZANEH ; ABDULLA, TARIQ ; MARTINS, FREDERICO ; ARORA, SUMIT ; TSAKALOZOU, ELEFTHERIA ; HODGKINSON, ARRAN ; ARJMANDI'TASH, OMID ; CRISTEA, SINZIANA ; GHOSH, PRIYANKA ; ALAM, KHONDOKER ; RANEY, SAM G. ; JAMEI, MASOUD ; POLAK, SEBASTIAN . Multi-phase multi-layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin. Cpt-Pharmacometrics & Systems Pharmacology , v. 11, p. 8, 2022.

• ZHU, SHIXING ; SONG, CHU ; ZHANG, JIAYUAN ; DIAO, SHUO ; HEINRICHS, TOBIAS M. ; MARTINS, FREDERICO S. ; LV, ZHIHUA ; ZHU, YUANQI ; YU, MINGMING ; SY, SHERWIN K. B. . Effects of amikacin, polymyxin-B, and sulbactam combination on the pharmacodynamic indices of mutant selection against multi-drug resistant Acinetobacter baumannii. Frontiers in Microbiology , v. 13, p. 1, 2022.

• MARTINS, F. S. ; SY, SHERWIN K. B. ; CONCEIÇÃO, E. C ; FONSECA, M. J. V. ; FREITAS, O. . Pharmacokinetic-Pharmacodynamic Characterization of a Topical Photochemotherapy using Brosimum gaudichaudii in C56BL/6 mice. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy , v. 1, p. 1-1, 2021.

• FEDRIGO, NAYARA HELISANDRA ; SHINOHARA, DANIELLE ROSANI ; MAZUCHELI, JOSMAR ; NISHIYAMA, SHEILA ALEXANDRA BELINI ; CARRARA-MARRONI, FLORISTHER ELAINE ; MARTINS, FREDERICO SEVERINO ; ZHU, PEIJUAN ; YU, MINGMING ; SY, SHERWIN KENNETH B. ; TOGNIM, MARIA CRISTINA BRONHARO . Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy. Scientific Reports , v. 11, p. 11339, 2021.

• FENG, KUN ; JIA, NAN ; ZHU, PEIJUAN ; SY, SERUBBABEL ; LIU, YANFEI ; DONG, DANDAN ; ZHU, SHIXING ; ZHANG, JIAYUAN ; LIU, YUWEI ; MARTINS, FREDERICO S ; GONG, HUGH ; LV, ZHIHUA ; YU, MINGMING ; SY, SHERWIN K B ; ZHU, YUANQI . Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of harbouring serine- and New Delhi metallo-β-lactamases. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY , v. 1, p. 11339, 2021.

• SANTOS, LUIZ GUSTAVO DA FONSECA ; SEGALL, ADRIANA INÉS ; KI HAN, YONG ; KIZELMAN, MARIA PATRICIA ; FERREIRA, MAÍRA PERES ; SILVA, AMANDA CRISTINA FUNARI ; MARTINS, FREDERICO SEVERINO ; CASTRO, WHOCELY VICTOR DE ; FREITAS, OSVALDO DE ; COUTO, RENÊ OLIVEIRA DO . O efeito da divisão na qualidade e na liberação in vitro de cloridrato de metformina de comprimidos de liberação prolongada (XR). RESEARCH, SOCIETY AND DEVELOPMENT , v. 10, p. e368101119348, 2021.

• SCHALLER, STEPHAN ; MARTINS, FREDERICO S. ; BALAZKI, PAVEL ; BÖHM, SONJA ; BAUMGART, JOACHIM ; HILGER, RALF A. ; BEELEN, DIETRICH W. ; HEMMELMANN, CLAUDIA ; RING, ARNE . Evaluation of the Drug-Drug Interaction Potential of Treosulfan using a Physiologically-Based Pharmacokinetic Modelling Approach. British Journal of Clinical Pharmacology , v. 1, p. 555-601, 2021.

• MARTINS, FREDERICO SEVERINO ; SY, SHERWIN K.B. ; FONSECA, MARIA JOSÉ VIEIRA ; DE FREITAS, OSVALDO . Pharmacokinetics, Pharmacodynamics and Dermal Distribution of 5-Methoxypsoralen Based on a Physiologically Based Pharmacokinetic Model to Support Phytotherapy Using Brosimum gaudichaudii. PLANTA MEDICA , v. 85, p. 914, 2020.

• MARTINS, FREDERICO S. ; ZHU, PEIJUAN ; HEINRICHS, M. TOBIAS ; SY, SHERWIN K. B. . Physiologically based pharmacokinetic-pharmacodynamic evaluation of meropenem plus fosfomycin in paediatrics. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY , v. 12, p. 1, 2020.

• MARTINS, FREDERICO SEVERINO ; SY, SHERWIN K. B. ; DA CONCEIÇÃO, EDEMILSON CARDOSO ; FONSECA, MARIA JOSÉ VIEIRA ; DE FREITAS, OSVALDO . Melanogenic Effect and Toxicity Assessments of Standardized Extract of Brosimum gaudichaudii. BRAZILIAN JOURNAL OF PHARMACOGNOSY , v. 12, p. 1-601, 2020.

• SILVA, D. B. ; VIEIRA, R. F. ; MARTINS, FREDERICO S. ; Conceição,C.E ; PALHARES, L. A. M. P. M. D. . Avaliação preliminar de cultivo de Mama-cadela (Brosimum gaudichaudii Trécul. - Moraceae) em diferentes substratos. Documentos (Centro Nacional de Recursos Genéticos e Biotecnologia) , v. 1, p. 111, 2020.

• BIESDORF, CARLA ; MARTINS, FREDERICO S. ; SY, SHERWIN K.B. ; DINIZ, ANDREA . Physiologically-based pharmacokinetics of ziprasidone in pregnant women. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY , v. 85, p. 914-923, 2019.

• MARTINS, FREDERICO S ; BORGES, L. L. ; RIBEIRO, C. S. ; REIFSCHNEIDER, F. J. B. ; CONCEIÇÃO, E. C . Novel approaches to extraction methods in recovery of capsaicin from habanero pepper (CNPH 15.192). Pharmacognosy Magazine , v. 13, p. 375, 2017.

• DE MORAIS RODRIGUES, MARIANACRISTINA ; BORGES, LEONARDOLUIZ ; MARTINS, FREDERICOSEVERINO ; MOURÃO, ROSA HELENAV ; DA CONCEIÇÃO, EDEMILSONCARDOSO . Optimization of ultrasound-assisted extraction of phenolic compounds from Myrcia amazonica DC. (Myrtaceae) leaves. Pharmacognosy Magazine , v. 12, p. 9, 2016.

• MARTINS, F. S. ; CONCEIÇÃO, E. C. . Evaluation of extraction method on the chemical composition in Apeiba tibourbou Aubl¿s extracts. Pharmacognosy Magazine , v. 11, p. 368-373, 2015.

• SILVA FILHO, O. P. ; OLIVEIRA, L. A. R. ; MARTINS, F. S. ; BORGES, LEONARDO L. ; FREITAS, O. ; CONCEIÇÃO, E. C . Obtainment of pellets using the standardized liquid extract of Brosimum gaudichaudii Trécul (Moraceae). Pharmacognosy Magazine , v. 11, p. 170-175, 2015.

• MARTINS, F. S. ; Pascoa,H. ; Paula, José R. ; CONCEIÇÃO, E. C. . Technical aspects on production of fluid extract from Brosimum gaudichaudii Trécul roots. Pharmacognosy Magazine , v. 11, p. 226-231, 2015.

• BORGES, LEONARDO L. ; MARTINS, FREDERICO S. ; Conceição, Edemilson C. ; SILVEIRA, DÂMARIS . Optimization of the Spray-Drying Process for Developing Jabuticaba Waste Powder Employing Response Surface Methodology. JOURNAL OF FOOD PROCESS ENGINEERING , v. 40, p. e12276, 2015.

• MARTINS, F. S. ; CONCEIÇÃO, E. C ; BANDEIRA, E. S. ; COSTA, R. M. R. ; SILVA, J. O. C. . The effects of extraction method on recovery rutin from Calendula officinalis L. (Asteraceae). Pharmacognosy Magazine , v. 10, p. 569, 2014.

• IVAN, A. L. M. ; SILVA, M. Z. C. E. ; MARTINEZ, R. M. ; FERREIRA, V. S. ; STEFFEN, V. S. ; VICENTINI, F. T. M. C. ; VILELA, F. M. P. ; MARTINS, FREDERICO S. ; ZARPELON, A. C. ; CUNHA, T. M. ; FONSECA, M. J. V. ; BARACAT, M. M. ; GEORGETTI, S. R. ; VERRI JR, W. A. ; CASAGRANDE, R. . Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro. Journal of Photochemistry and Photobiology. B, Biology , v. 138, p. 124-133, 2014.

• MARTINS, F. S. ; BORGES, L. L. ; PAULA, J.R. ; Conceição,C.E . Impact of different extraction methods on the quality of Dipteryx alata extracts. Revista Brasileira de Farmacognosia (Impresso) , v. 23, p. 521-526, 2013.

• Couto, Renê O. ; MARTINS, F. S. ; CHAUL, LUIZA T. ; Conceição, Edemilson C. ; FREITAS, LUIS ALEXANDRE P. ; Bara, Maria Teresa F. ; PAULA, J. R. . Spray drying of Eugenia dysenterica extract: effects of in-process parameters on product quality. Revista Brasileira de Farmacognosia (Impresso) , v. 23, p. 115-123, 2013.

• da Mota MF ; Benfica PL ; Batista AC ; MARTINS, F. S. ; PAULA, J.R. ; VALADARES, M.C . Investigation of Ehrlich ascites tumor cell death mechanisms induced by Synadenium umbellatum Pax.. Journal of Ethnopharmacology , v. 139, p. 319-329, 2012.

• OLIVEIRA, E. M. S. ; FARIAS, S. S. ; MARTINS, F. S. ; Pinto M.V ; Paula, José R. ; COUTO, R. O. ; PAULA, J.R. ; Conceição,C.E ; BARA, M. T. . Isolation and quantitative HPLC-PDA analysis of lupeol in phytopharmaceutical intermediate products from Vernonanthura ferruginea (Less.) H. Rob.. Química Nova (Impresso) , v. 35, p. 1041-1045, 2012.

• COUTO, R. O. ; OLIVEIRA, E. M. S. ; MARTINS, F. S. ; FREITAS, O. ; BARA, M. T. ; PAULA, J.R. ; Conceição,C.E . Processing of Apeiba tibourbou AUBL. extract via spray drying.. Acta Farmaceutica Bonaerense , v. 31, p. 104-111, 2012.

• COUTO, R. O. ; Conceição,C.E ; Chaul, L.T ; OLIVEIRA, E. M. S. ; MARTINS, F. S. ; BARA, M. T. ; Rezende,R.K ; Alves,F.S ; PAULA, J.R. . Spray-dried rosemary extracts: Physicochemical and antioxidant properties. Food Chemistry , v. 131, p. 99-105, 2011.

• Moraes, C. S. S ; MARTINS, F. S. ; BARA, M. T. ; PAULA, J.R. ; Conceição,C.E . Characterization and quality control of Ocimum gratissimum L. leaf powder and development of a standardized ethanolic extract. Journal of Pharmacy Research , v. 4, p. 3256-2358, 2011.

• MARTINS, F. S. ; Moraes, C. S. S ; PAULA, J.R. ; BARA, M. T. ; Conceição,C.E . Obtainment and characterization of raw material of Brosimum gaudichaudii Trecul (Moraceae). Journal of Pharmacy Research , v. 4, p. 3772-3775, 2011.

• MARTINS, F. S. ; SCHALLER, STEPHAN . Modeling Drug Metabolism and Excretion. In: Taylor & Francis. (Org.). Modeling Drug Metabolism and Excretion. 4ed.Boca Raton: CRC Press, 2024, v. 1, p. 100-114.

• Castro,T.R ; MARTINS, F. S. ; BARA, M. T. ; Paula, José R. ; CONCEIÇÃO, E. C . Optimization of Extratoin Hydroalcoholic Brosimmum Gaudichaudii Trécul (Moraceae). In: 8º International Congress of Pharmaceutical Sciencies, 2011, Ribeirão Preto. . Anais do 8º International Congress of Pharmaceutical Sciencies, 2011.

• MARTINS, F. S. ; CONCEIÇÃO, E. C . Extração e caracterização do lipídes dos óleos de sementes de Apeiba Tibourbou Aubl (pau jangada, pente de macaco) por CCD procedntes de diferentes regiões do estado de Goiás. In: Congresso de pesquisa, ensino e extensão, 2008, Goiânia. CONPEEX, 2008.

• CONCEIÇÃO, E. C ; Eduardo Ramirez Asquieri ; Eric de Souza Gil ; FARIA, B. E. F. ; MARTINS, F. S. ; Fernado D Correia ; BARA,M.T ; Renata P. Duarte ; PAULA, Jose Realino de ; GARROTE, C. F. D. . AVALIAÇÃO DO COMPORTAMENTO REOLOGICO DE EMULÕES COSMETICAS COM ÓLEOS DE AÇÍ (EUTERPE OLERACEA MART) E MARACUJÁ(PASSIFLORA EDULIS). In: 4ª Congresso de Palantas Oleaginosas, Óleos, Gurduras e Biodisel, 2007, Varginha. Biodiesel: Combustível Ecológico, 2007. v. 2. p. 175-175.

• MARTINS, F. S. ; POLAK, S. ; PATEL, N. ; JAMEI, M. . Development and validation of a dermal PBPK model for prediction of the hair follicular absorption of caffeine: Application of the Simcyp MechDermA model. In: 14th Eur ISSX, Germany, 2017, Cologne. 14th Eur ISSX, Germany, 2017.

• MARTINS, F. S. ; PATEL, N. ; POLAK, S. ; JAMEI, M. . Multi-phase Multi-layer MechDermA model: Development, verification and application of a PBPK-PD model of dermal absorption for transdermal product assessment. In: Gordon Research Conference, 2017, Boston. Gordon Research Conference, 2017.

• MARTINS, F. S. ; BARA, M. T. ; Paula, José R. ; CONCEIÇÃO, E. C . Optimization of the ultrasound-assisted of psoralen and bergapten from Brosimum gaudichaudii Trécul roots.. In: XXII SIMPÓSIO DE PLANTAS MEDICINAIS DO BRASIL, 2012, Bento Gonçalves. Anais XXII SPMB, 2012.

• BORGES, L. L. ; MARTINS, F. S. ; CONCEIÇÃO, E. C ; SILVEIRA, D. . Validation of analytical method for quantification of ellagic acid in fruits peels from Myrciaria cauliflora (Mart.) O. Berg.. In: XXII SIMPÓSIO DE PLANTAS MEDICINAIS DO BRASIL, 2012, Bento Gonçalves. Anais XXII SPMB, 2012.

• GALVAO, M. A. M. ; MARTINS, F. S. ; CONCEIÇÃO, E. C . Determination of total phenols and flavonoids for evaluation of antioxidant activity in vitro and characterization of furanocoumarins by HPLC in seeds of Brosimum gaudichaudii Trécul (Moraceae). In: XXII SIMPÓSIO DE PLANTAS MEDICINAIS DO BRASIL, 2012. Anais XXII SPMB, 2012.

• MARTINS, F. S. ; Moraes, C. S. S ; Cardoso, N.Q ; CONCEIÇÃO, E. C . Caracterização da droga vegetal de Brasimim gaudichaudii Trécul. In: 63ª Reunião Anual da SBPC, 2011, Goiânia. Anais/Resumos da 62ª Reunião Anual da SBPC, 2011.

• Faria,M,J.M ; SOUSA, J. N. ; Cardoso, N.Q ; MARTINS, F. S. ; BARA, M. T. ; Paula, José R. ; CONCEIÇÃO, E. C . COMPARISON OF THEREE METHODS OF EXTRACTION OF TANNINS PRESENTS IN THE STEM BARKS OF Stryphnodendron adstringes (MARTIUS) COVILLE (BARBATIMÃO). In: 3º Conference on Natural Products,XXIX RESEM and VII SFL Held, 2011, Ouro Preto. Anais 3º Conference on Natural Products,XXIX RESEM and VII SFL Held, 2011.

• SANTOS, J. P. F. ; MARTINS, F. S. ; CONCEIÇÃO, E. C . Extração e caracterização dos lipídeos dos óleos das sementes de Annona crassiflora Mart.. In: 63ª Reunião Anual da SBPC, 2011, Goiânia. Anais 63ª Reunião Anual da SBPC, 2011.

• Moraes, C. S. S ; MARTINS, F. S. ; CONCEIÇÃO, E. C . Obtenção do extrato etanólico de Ocimum gratissimum L. In: 63º Reunião Anual da SPPC, 2011, Goiânia. Anais/Resumos da 62ª Reunião Anual da SBPC, 2011.

• Alcântara,G.A ; BORGES, L. L. ; MARTINS, F. S. ; Martins, M.R ; SOUSA, J. N. ; CONCEIÇÃO, E. C . Optmization of Ultrasound-Assisted of Phenolic compounds from Rosa centiflora by Response Surface Metodology. In: 3º Conference on Natural Products,XXIX RESEM and VII SFL Held, 2011. Anais do 3º Conference on Natural Products,XXIX RESEM and VII SFL Held, 2011.

• Miguel, K.P.R ; Moraes, C. S. S ; MARTINS, F. S. ; SILVA FILHO, O. ; CONCEIÇÃO, E. C . Validation of Analytical Method for Determination of Total Phenols in Ocimim gratissimum L. Leaves. In: 3º Conference on Natural Products,XXIX RESEM and VII SFL Held, 2011. Anais da 3º Conference on Natural Products,XXIX RESEM and VII SFL Held, 2011.

• GARCIA, N. ; MARTINS, F. S. ; BORGES, L. L. ; Cardoso, N.Q ; CONCEIÇÃO, E. C . OPTIMIZATION OF ULTRASOUND-ASSISTED EXTRACTION OF PHENOLS FROM Hibiscus sabdariffa L. In: 3º Conference on Natural Products,XXIX RESEM and VII SFL Held, 2011. Anais do 3º Conference on Natural Products,XXIX RESEM and VII SFL Held, 2011.

• CONCEIÇÃO, E. C ; Alcântara,G.A ; MARTINS, F. S. ; PAULA, J.R. ; BARA, M. T. ; Silva,D.B ; Marques,B.R . Avaliação da Influência da Idade nos Teores de Psoraleno e Bergapteno em Extratos de Brosimum Gaudichaudii Trecul (MARACEAE). In: XXI Simpósio de Plantas Medicinais do Brasil, 2010, Jõao Pessoa-PB. Anais do XXI Simpósio de Plantas Medicinais do Brasil, 2010.

• MACENTE, J. ; NAUWELAERTS, N. ; BADEE, U. M. ; BONAN, R. H. ; HUANG, M. ; NESTE, M. V. ; ALLEGAERT, K. ; MARTINS, F. S. ; ANNAERT, P. . PHYSIOLOGICALLY-BASED PHARMACOKINETICS MODELLING TO PREDICT DRUG CONCENTRATION IN HUMAN MILK: A CONTRIBUTION FROM THE CONCEPTION PROJECT. 2024. (Apresentação de Trabalho/Congresso).

• MARTINS, F. S. ; Couto, R.O ; FREITAS, O. . Establishment of Virtual Bioequivalence via DoE-PBBM Model: A Donepezil Case Study. 2023. (Apresentação de Trabalho/Congresso).

• MACENTE, J. ; NAUWELAERTS, N. ; MARTINS, F. S. ; ANNAERT, PIETER . Physiologically-based Pharmacokinetics modelling to predict the systemic exposure of medicines in infants via breastmilk: a contribution from the ConcePTION Project.. 2023. (Apresentação de Trabalho/Congresso).

• NAUWELAERTS, N. ; MACENTE, J. ; BONAN, R. H. ; MARTINS, F. S. ; ANNAERT, PIETER ; MARTINS, FREDERICO S . Physiologically Based Pharmacokinetic (PBPK) Modelling to Predict Human Milk Exposure to medicines: a contribution from the ConcePTION Project. 2023. (Apresentação de Trabalho/Congresso).

• MACENTE, J. ; NAUWELAERTS, N. ; MARTINS, F. S. ; ANNAERT, PIETER . Application of Physiologically-Based Pharmacokinetics using Simcyp to predict the exposure to Valproic Acid in human milk and pediatrics. 2022. (Apresentação de Trabalho/Congresso).

• MACENTE, J. ; NAUWELAERTS, N. ; MARTINS, F. S. ; ANNAERT, PIETER . Application of Physiologically-Based Pharmacokinetics using Simcyp to predict the exposure to Valproic Acid in human milk and pediatrics. 2022. (Apresentação de Trabalho/Conferência ou palestra).

• RE, F. ; CASTRO, F. A. ; SOUZA, F. P. ; LIMA, M. M. S. ; CRISTOFOLETTI, R. ; SCHALLER, S. ; DINIZ, A. ; MARTINS, F. S. . Using Physiologically Based Absorption Modeling to assess the failing bioequivalence of ziprasidone capsules. 2020. (Apresentação de Trabalho/Congresso).

• MARTINS, F. S. . Application of Physiologically Based Pharmacokinetic (PBPK) Modelling to Support First in Human dose selection.. 2019. (Apresentação de Trabalho/Conferência ou palestra).

• POLAK, S. ; MARTINS, F. S. ; PATEL, N. . Predicting diclofenac systemic and synovial fluid concentrations after dermal application using the Multi-Phase Multi-Layer MechDermA PBPK model. 2017. (Apresentação de Trabalho/Conferência ou palestra).

• N. Patel, ; MARTINS, F. S. ; JAMEI, M. ; POLAK, S. . Integration of Physicochemical Product Characteristics within a Mechanistic Dermal PBPK Model to Support Virtual Bioequivalence Evaluation of Topical Drug Products: A Case Study with Acyclovir Topical Creams. 2017. (Apresentação de Trabalho/Congresso).

• ABIDULA, T. ; PATEL, N. ; POLAK, S. ; MARTINS, F. S. . Quantitative prediction of dermal drug absorption using MPML-MechDermA model: Relative effects of application site on rivastigmine pharmacokinetics from a transdermal delivery system. 2017. (Apresentação de Trabalho/Comunicação).

• MARTINS, F. S. ; PATEL, N. ; POLAK, S. . Development and validation of Dermal PBPK model towards virtual bioequivalence assessment: Prediction of dermal drug absorption of various Ibuprofen formulations using Simcyp MechDermA model. 2016. (Apresentação de Trabalho/Conferência ou palestra).

• MARTINS, F. S. ; Bara MTF ; PAULA, J.R. ; CONCEIÇÃO, E. C . Optimization of the ultrasound-assisted of psoralen and bergapten from Brosimum gaudichaudii Trécul roots.. 2012. (Apresentação de Trabalho/Simpósio).

• MATOS, M. A. J. ; MARTINS, F. S. ; CONCEIÇÃO, E. C . Determination of Total Phenols and Flavonoids for evaluation of antioxidant activity in vitro and characterization of furanocoumarins by HPLC in seeds of Brosimum gaudichaudii Trécul (Moraceae). 2012. (Apresentação de Trabalho/Simpósio).

• BORGES, L. L. ; MARTINS, F. S. ; Conceição,C.E . Validation of analitical method for quantificationof ellagic acid in fruits of peels from Myrciaria cauliflora. (Mart) O.Berg. 2012. (Apresentação de Trabalho/Simpósio).

• SANTOS, J. P. F. ; MARTINS, F. S. ; CONCEIÇÃO, E. C . Extração e caracterização dos lipídeos dos óleos das sementes de Annona crassiflora Mart.. 2011. (Apresentação de Trabalho/Congresso).

• Mulser,H. ; MARTINS, F. S. ; Miguel, K.P.R ; Pascoa,H. ; BARA, M. T. ; PAULA, J.R. ; CONCEIÇÃO, E. C . Validation of analytical method for dertemination of polyphenols in Rosmarinus officinalis L.. 2011. (Apresentação de Trabalho/Congresso).

• Castro,T.R ; MARTINS, F. S. ; BARA, M. T. ; PAULA, J.R. ; CONCEIÇÃO, E. C . Optimization of Extratoin Hydroalcoholic Brosimmum Gaudichaudii Trécul (Moraceae). 2011. (Apresentação de Trabalho/Congresso).

• Miguel, K.P.R ; Moraes, C. S. S ; MARTINS, F. S. ; Pascoa,H. ; Mulser,H. ; BARA, M. T. ; PAULA, J.R. ; CONCEIÇÃO, E. C . Ultrasound-Assisted Extration of Total Phenol in Apeiba tirbourbou Aubl Influence of the alcoholic concentration. 2011. (Apresentação de Trabalho/Congresso).

• Moraes, C. S. S ; MARTINS, F. S. ; CONCEIÇÃO, E. C . Obtenção do extrato etanólico de Ocimum gratissimum L. 2011. (Apresentação de Trabalho/Outra).

• MARTINS, F. S. ; Moraes, C. S. S ; CONCEIÇÃO, E. C ; Cardoso, N.Q . Caracterização da droga vegetal de Brasimim gaudichaudii Trécul. 2011. (Apresentação de Trabalho/Outra).

• Miguel, K.P.R ; Moraes, C. S. S ; MARTINS, F. S. ; SILVA FILHO, O. ; CONCEIÇÃO, E. C . Validation of Analytical Method for Determination of Total Phenols in Ocimim gratissimum L. Leaves. 2011. (Apresentação de Trabalho/Conferência ou palestra).

• Alcântara,G.A ; BORGES, L. L. ; MARTINS, F. S. ; GARCIA, N. ; SOUSA, J. N. ; CONCEIÇÃO, E. C . Optmization of Ultrasound-Assisted of Phenolic compounds from Rosa centiflora by Response Surface Metodology. 2011. (Apresentação de Trabalho/Conferência ou palestra).

• MARTINS, F. S. ; Moraes, C. S. S ; Loures,P.K.R ; Paula, José R. ; BARA, M. T. ; CONCEIÇÃO, E. C . Characterization of Brosimum Gaudichaudii Trécul (MORACEAE) Roots Powder. 2011. (Apresentação de Trabalho/Conferência ou palestra).

• Couto, R.O ; CONCEIÇÃO, E. C ; Chaul, L.T ; MARTINS, F. S. ; BARA, M. T. ; Paula, José R. . ROLE OF IN-PROCESS PARAMETERS ON THE PHYSICO-MECHANICAL PROPERTIES OF SPRAY-DRIED ROSEMARY EXTRACTS. 2011. (Apresentação de Trabalho/Conferência ou palestra).

• Couto RO ; CONCEIÇÃO, E. C ; Chaul, L.T ; OLIVEIRA, E. M. S. ; MARTINS, F. S. ; Rezende,R.K ; BARA, M. T. ; PAULA, Jose Realino de . PHYSICOCHEMICAL AND ANTIOXIDANT PROPERTIES OF SPRAY-DRIED ROSEMARY EXTRACTS. 2011. (Apresentação de Trabalho/Conferência ou palestra).

• Faria,M,J.M ; SOUSA, J. N. ; Cardoso, N.Q ; MARTINS, F. S. ; BARA, M. T. ; PAULA, Jose Realino de ; CONCEIÇÃO, E. C . COMPARISON OF THEREE METHODS OF EXTRACTION OF TANNINS PRESENTS IN THE STEM BARKS OF Stryphnodendron adstringes (MARTIUS) COVILLE (BARBATIMÃO). 2011. (Apresentação de Trabalho/Conferência ou palestra).

• GARCIA, N. ; Martins, M.R ; MARTINS, F. S. ; BORGES, L. L. ; Cardoso, N.Q ; CONCEIÇÃO, E. C . OPTIMIZATION OF ULTRASOUND-ASSISTED EXTRACTION OF PHENOLS FROM Hibiscus sabdariffa L. 2011. (Apresentação de Trabalho/Conferência ou palestra).

• Juliana Dias Santos ; MARTINS, F. S. ; Godois,R.M ; Lutosa,K.R.M.D ; Macedo,T.C.M ; CONCEIÇÃO, E. C . Principais Irregularidades de Fitoterápicos em Goiânia nos Anos de 2007, 2008 e 2009. 2010. (Apresentação de Trabalho/Outra).

• MARTINS, F. S. ; Moraes, C. S. S ; PAULA, J.R. ; BARA, M. T. ; CONCEIÇÃO, E. C . Desenvolvimento de Método Analítico Para Analise dos Áscidos Graxos Provenientes Das Sementes de Apeiba tirbourbou Aubl. 2010. (Apresentação de Trabalho/Outra).

• Alcântara,G.A ; MARTINS, F. S. ; PAULA, J.R. ; BARA, M. T. ; Silva,D.B ; Marques,B.R ; CONCEIÇÃO, E. C . Infuência da Idade nos Teores de Psoraleno e Bergapteno em Extratos de Brosimum Gaudichaudi Trecul (Moraceae). 2010. (Apresentação de Trabalho/Simpósio).

• MARTINS, F. S. ; CONCEIÇÃO, E. C . Extração e Caracterização dos Lípideos dos Óleos de Sementes de Pterodon Amarginatus Vogel (Sucupira Branca). 2010. (Apresentação de Trabalho/Congresso).

• Couto RO ; ARAUJO R.R ; MARTINS, F. S. ; BARA, M. T. ; CONCEIÇÃO, E. C ; PAULA, Jose Realino de . Role of Technological Adjuvants on Eugenia Dysenterica DC. (Myrtaceae) Spray-Drying. 2009. (Apresentação de Trabalho/Congresso).

• Sampaio BL ; PAULA, J.R. ; Couto RO ; MARTINS, F. S. . Variability on phenolic compounds contents of Lafoensia pacari A. St.-Hill. Collected in different regions. 2009. (Apresentação de Trabalho/Congresso).

• Couto RO ; MARTINS, F. S. ; Sampaio BL ; Ferri PH ; CONCEIÇÃO, E. C ; PAULA, J.R. ; BARA, M. T. . Teor e composição dos óleos essenciais das folhas de uma população de Eugenia dysenterica (MYRTACEA). 2009. (Apresentação de Trabalho/Congresso).

• MARTINS, F. S. ; Couto RO ; PAULA, J.R. ; Sampaio BL ; CONCEIÇÃO, E. C . Extração e caracterização dos óleos fixos provenientes das amêndoas de Caryocar brasiliense Cambess (CARYOCARACEAE).(. 2009. (Apresentação de Trabalho/Congresso).

• Sampaio BL ; PAULA, J.R. ; Couto RO ; MARTINS, F. S. ; Sá FAS ; Costa EA . Determinação dos teores de fenóis presentes nas folhas e nas cascas de Lafoensia pacari A. ST-HILL. 2009. (Apresentação de Trabalho/Congresso).

• MARTINS, F. S. ; CONCEIÇÃO, E. C . Extração e caracterização dos lipídeos dos óleos de sementes de Apeiba Tibourbou Aubl (pau jangada, pente de macaco) por Cromatografia em Fase Gasosa procedntes de diferentes regiões do estado de Goiás. 2009. (Apresentação de Trabalho/Congresso).

• MARTINS, F. S. ; CONCEIÇÃO, E. C . Extração e caracterização dos lipídes dos óleos de sementes de Apeiba Tibourbou Aubl (pau jangada, pente de macaco) por CCD procedentes de diferentes regiões do estado de Goiás. 2008. (Apresentação de Trabalho/Congresso).

• CONCEIÇÃO, E. C ; PAULA, Jose Realino de ; GARROTE, Clévia Ferreira Duarte ; FARIA, B. E. F. ; Eduardo Ramirez Asquieri ; BARA,M.T ; MARTINS, F. S. ; Fernado D Correia ; Eric de Souza Gil ; Renata P. Duarte . AVALIAÇÃO DO COMPORTAMANETO REOLÓGICO DE EMULSÕES COSMÉTICAS COM OS ÓLEOS DE AÇAÍ( EUTERPE OLERACEA MART) E MARACUJÁ(PASSIFLORA EDULIS). 2007. (Apresentação de Trabalho/Congresso).

Outras produções

Projetos de desenvolvimento

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2014 - 2018

  Multi-phase Multi-layer MechDermA (Mechanistic Dermal Absorption) Model for geriatrics and effect of sex on physiologic parameters, Descrição: A grant from the U.S. Food and Drug Administration (FDA) will support the enhancement of a technology that is playing an increasingly important role in the drug development process. The Office of Generic Drugs has awarded Certara a three-year grant valued at up to $400,000 to support expanded capabilities for its Simcyp Simulator, a physiologically based pharmacokinetic (PBPK) modeling platform. The platform, which is used by most major pharmaceutical companies and regulatory agencies, is used to analyse dosing regimens, determine drug-drug interactions, inform study design and guide appropriate labelling language. Project number 1U01FD005225-01. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Frederico Severino Martins - Coordenador / Sebastian Polak - Integrante / Nikunjkumar Patel - Integrante.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento.

• 2014 - 2018

  Multi-phase Multi-layer MechDermA (Mechanistic Dermal Absorption) Model for geriatrics and effect of sex on physiologic parameters, Descrição: A grant from the U.S. Food and Drug Administration (FDA) will support the enhancement of a technology that is playing an increasingly important role in the drug development process. The Office of Generic Drugs has awarded Certara a three-year grant valued at up to $400,000 to support expanded capabilities for its Simcyp Simulator, a physiologically based pharmacokinetic (PBPK) modeling platform. The platform, which is used by most major pharmaceutical companies and regulatory agencies, is used to analyse dosing regimens, determine drug-drug interactions, inform study design and guide appropriate labelling language. Project number 1U01FD005225-01. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Frederico Severino Martins - Coordenador / Sebastian Polak - Integrante / Nikunjkumar Patel - Integrante.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2018 - Atual

  Multi-phase, Multi-layer (MPML) MechDermA skin model, Descrição: This grant will fund enhancements to Certara?s PBPK multi-phase, multi-layer (MPML) MechDermA skin model to include the quantitative description of disease-triggered histological and functional modifications to the skin. The resulting models will be able to factor in the thickness of various skin layers, presence of cracks, dryness, modification of blood flow and skin temperature, sebaceous gland infection and inflammation, flaking, and the presence of pustules, comedones, vacuoles, cysts, and pseudocysts. Histopathological modifications to Simcyp?s healthy skin model will permit development of models for specific skin diseases. The resulting disease models will all be verified using clinical data from the literature. The inclusion of skin disease states in PBPK models will help pharma companies to develop non-Q1/Q2/Q3 formulations and simulate their in vivo performance in patient populations to further support their substitutability in diseased skin. In evaluating bioequivalence, the FDA uses Q1 to define qualitative equivalence (test and reference products contain the same active and inactive ingredients), Q2 for quantitative equivalence (test and reference products contain the same amounts of active and inactive ingredients), and Q3 for physicochemical attributes of a specific dosage form. Grant of U$ 400 000,00. , Situação: Em andamento; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante / Michael Roberts - Integrante.

• 2014 - 2018

  Multi-phase Multi-layer MechDermA (Mechanistic Dermal Absorption) Model for geriatrics and effect of sex on physiologic parameters, Descrição: A grant from the U.S. Food and Drug Administration (FDA) will support the enhancement of a technology that is playing an increasingly important role in the drug development process. The Office of Generic Drugs has awarded Certara a three-year grant valued at up to $400,000 to support expanded capabilities for its Simcyp Simulator, a physiologically based pharmacokinetic (PBPK) modeling platform. The platform, which is used by most major pharmaceutical companies and regulatory agencies, is used to analyse dosing regimens, determine drug-drug interactions, inform study design and guide appropriate labelling language. Project number 1U01FD005225-01. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante., Financiador(es): U.S. Food and Drug Administration - Cooperação.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2018 - Atual

  Multi-phase, Multi-layer (MPML) MechDermA skin model, Descrição: This grant will fund enhancements to Certara?s PBPK multi-phase, multi-layer (MPML) MechDermA skin model to include the quantitative description of disease-triggered histological and functional modifications to the skin. The resulting models will be able to factor in the thickness of various skin layers, presence of cracks, dryness, modification of blood flow and skin temperature, sebaceous gland infection and inflammation, flaking, and the presence of pustules, comedones, vacuoles, cysts, and pseudocysts. Histopathological modifications to Simcyp?s healthy skin model will permit development of models for specific skin diseases. The resulting disease models will all be verified using clinical data from the literature. The inclusion of skin disease states in PBPK models will help pharma companies to develop non-Q1/Q2/Q3 formulations and simulate their in vivo performance in patient populations to further support their substitutability in diseased skin. In evaluating bioequivalence, the FDA uses Q1 to define qualitative equivalence (test and reference products contain the same active and inactive ingredients), Q2 for quantitative equivalence (test and reference products contain the same amounts of active and inactive ingredients), and Q3 for physicochemical attributes of a specific dosage form. Grant of U$ 400 000,00. , Situação: Em andamento; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante / Michael Roberts - Integrante.

• 2014 - 2018

  Multi-phase Multi-layer MechDermA (Mechanistic Dermal Absorption) Model for geriatrics and effect of sex on physiologic parameters, Descrição: A grant from the U.S. Food and Drug Administration (FDA) will support the enhancement of a technology that is playing an increasingly important role in the drug development process. The Office of Generic Drugs has awarded Certara a three-year grant valued at up to $400,000 to support expanded capabilities for its Simcyp Simulator, a physiologically based pharmacokinetic (PBPK) modeling platform. The platform, which is used by most major pharmaceutical companies and regulatory agencies, is used to analyse dosing regimens, determine drug-drug interactions, inform study design and guide appropriate labelling language. Project number 1U01FD005225-01. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante., Financiador(es): U.S. Food and Drug Administration - Cooperação.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2016 - 2019

  Multi-phase, Multi-layer (MPML) MechDermA skin model, Descrição: This grant will fund enhancements to Certara?s PBPK multi-phase, multi-layer (MPML) MechDermA skin model to include the quantitative description of disease-triggered histological and functional modifications to the skin. The resulting models will be able to factor in the thickness of various skin layers, presence of cracks, dryness, modification of blood flow and skin temperature, sebaceous gland infection and inflammation, flaking, and the presence of pustules, comedones, vacuoles, cysts, and pseudocysts. Histopathological modifications to Simcyp?s healthy skin model will permit development of models for specific skin diseases. The resulting disease models will all be verified using clinical data from the literature. The inclusion of skin disease states in PBPK models will help pharma companies to develop non-Q1/Q2/Q3 formulations and simulate their in vivo performance in patient populations to further support their substitutability in diseased skin. In evaluating bioequivalence, the FDA uses Q1 to define qualitative equivalence (test and reference products contain the same active and inactive ingredients), Q2 for quantitative equivalence (test and reference products contain the same amounts of active and inactive ingredients), and Q3 for physicochemical attributes of a specific dosage form. Grant of U$ 400 000,00. , Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante / Michael Roberts - Integrante.

• 2014 - 2018

  Multi-phase Multi-layer MechDermA (Mechanistic Dermal Absorption) Model for geriatrics and effect of sex on physiologic parameters, Descrição: A grant from the U.S. Food and Drug Administration (FDA) will support the enhancement of a technology that is playing an increasingly important role in the drug development process. The Office of Generic Drugs has awarded Certara a three-year grant valued at up to $400,000 to support expanded capabilities for its Simcyp Simulator, a physiologically based pharmacokinetic (PBPK) modeling platform. The platform, which is used by most major pharmaceutical companies and regulatory agencies, is used to analyse dosing regimens, determine drug-drug interactions, inform study design and guide appropriate labelling language. Project number 1U01FD005225-01. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante., Financiador(es): U.S. Food and Drug Administration - Cooperação.

• 2009 - 2010

  Extração e caracterização dos lipídes dos óleos das sementes de Pterodon emarginatus Vogel (sucupira branca), Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Coordenador.

• 2016 - 2019

  Multi-phase, Multi-layer (MPML) MechDermA skin model, Descrição: This grant will fund enhancements to Certara?s PBPK multi-phase, multi-layer (MPML) MechDermA skin model to include the quantitative description of disease-triggered histological and functional modifications to the skin. The resulting models will be able to factor in the thickness of various skin layers, presence of cracks, dryness, modification of blood flow and skin temperature, sebaceous gland infection and inflammation, flaking, and the presence of pustules, comedones, vacuoles, cysts, and pseudocysts. Histopathological modifications to Simcyp?s healthy skin model will permit development of models for specific skin diseases. The resulting disease models will all be verified using clinical data from the literature. The inclusion of skin disease states in PBPK models will help pharma companies to develop non-Q1/Q2/Q3 formulations and simulate their in vivo performance in patient populations to further support their substitutability in diseased skin. In evaluating bioequivalence, the FDA uses Q1 to define qualitative equivalence (test and reference products contain the same active and inactive ingredients), Q2 for quantitative equivalence (test and reference products contain the same amounts of active and inactive ingredients), and Q3 for physicochemical attributes of a specific dosage form. Grant of U$ 400 000,00. , Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante / Michael Roberts - Integrante.

• 2014 - 2018

  Multi-phase Multi-layer MechDermA (Mechanistic Dermal Absorption) Model for geriatrics and effect of sex on physiologic parameters, Descrição: A grant from the U.S. Food and Drug Administration (FDA) will support the enhancement of a technology that is playing an increasingly important role in the drug development process. The Office of Generic Drugs has awarded Certara a three-year grant valued at up to $400,000 to support expanded capabilities for its Simcyp Simulator, a physiologically based pharmacokinetic (PBPK) modeling platform. The platform, which is used by most major pharmaceutical companies and regulatory agencies, is used to analyse dosing regimens, determine drug-drug interactions, inform study design and guide appropriate labelling language. Project number 1U01FD005225-01. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante., Financiador(es): U.S. Food and Drug Administration - Cooperação.

• 2016 - 2019

  Multi-phase, Multi-layer (MPML) MechDermA skin model, Descrição: This grant will fund enhancements to Certara?s PBPK multi-phase, multi-layer (MPML) MechDermA skin model to include the quantitative description of disease-triggered histological and functional modifications to the skin. The resulting models will be able to factor in the thickness of various skin layers, presence of cracks, dryness, modification of blood flow and skin temperature, sebaceous gland infection and inflammation, flaking, and the presence of pustules, comedones, vacuoles, cysts, and pseudocysts. Histopathological modifications to Simcyp?s healthy skin model will permit development of models for specific skin diseases. The resulting disease models will all be verified using clinical data from the literature. The inclusion of skin disease states in PBPK models will help pharma companies to develop non-Q1/Q2/Q3 formulations and simulate their in vivo performance in patient populations to further support their substitutability in diseased skin. In evaluating bioequivalence, the FDA uses Q1 to define qualitative equivalence (test and reference products contain the same active and inactive ingredients), Q2 for quantitative equivalence (test and reference products contain the same amounts of active and inactive ingredients), and Q3 for physicochemical attributes of a specific dosage form. Grant of U$ 400 000,00. , Situação: Concluído; Natureza: Desenvolvimento. , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante / Michael Roberts - Integrante.

• 2014 - 2018

  Multi-phase Multi-layer MechDermA (Mechanistic Dermal Absorption) Model for geriatrics and effect of sex on physiologic parameters, Descrição: A grant from the U.S. Food and Drug Administration (FDA) will support the enhancement of a technology that is playing an increasingly important role in the drug development process. The Office of Generic Drugs has awarded Certara a three-year grant valued at up to $400,000 to support expanded capabilities for its Simcyp Simulator, a physiologically based pharmacokinetic (PBPK) modeling platform. The platform, which is used by most major pharmaceutical companies and regulatory agencies, is used to analyse dosing regimens, determine drug-drug interactions, inform study design and guide appropriate labelling language. Project number 1U01FD005225-01. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Frederico Severino Martins - Integrante / Sebastian Polak - Coordenador / Nikunjkumar Patel - Integrante., Financiador(es): U.S. Food and Drug Administration - Cooperação.

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