Maria de Fatima Somerlate Barbosa

Pós-doutorado

Idiomas

Áreas de atuação

Produções bibliográficas

• BARBOSA, MARIA D.F.S. ; GOKEMEIJER, JOCHEM ; MARTIN, AARON D. ; BUSH, ALEX . Altering drug tolerance of surface plasmon resonance assays for the detection of anti-drug antibodies. Analytical Biochemistry (Print) , v. 441, p. 174-179, 2013.

• BARBOSA, MARIA D.F.S. ; GLEASON, CAROL R. ; PHILLIPS, KELLI R. ; BERISHA, FLORA ; STOUFFER, BRUCE ; WARRACK, BETHANNE M. ; CHEN, GUODONG . Addressing drug effects on cut point determination for an anti-drug antibody assay. Journal of Immunological Methods (Print) , v. 384, p. 152-156, 2012.

• BARBOSA, MARIA D.F.S. ; KUMAR, SANDEEP ; LOUGHREY, HELEN ; SINGH, SATISH K. . Biosimilars and biobetters as tools for understanding and mitigating the immunogenicity of biotherapeutics. Drug Discovery Today , v. 17, p. 1282-1288, 2012.

• BARBOSA, MARIA D.F.S. . Immunogenicity of biotherapeutics in the context of developing biosimilars and biobetters. Drug Discovery Today , v. 16, p. 345-353, 2011.

• BARBOSA, M. D. F. S. ; CELIS, E. . Immunogenicity of protein therapeutics and the interplay between tolerance and antibody responses. Drug Discovery Today , v. 12, p. 674-681, 2007.

• BARBOSA, M. D. F. S. ; Vielmeter, J. ; Chu, S. ; Jacinto, J. . Clinical link between MHC class II haplotype and interferon-beta (IFN-B) immunogenicity. Clinical Immunology (Orlando) , v. 118, p. 42-50, 2006.

• DeVito, J.A. ; Mills, J.A. ; Liu, V.G. ; Agarwal, A. ; Sizemore, C.F. ; Yao, Z. ; Stoughton, D.M. ; Cappielo, M.G. ; BARBOSA, M. D. F. S. ; Foster, L.A. ; D.L. Pompliano . An array of target-specific screening strains for antimicrobial discovery. Nature Biotechnology , v. 20, p. 478-483, 2002.

• BARBOSA, M. D. F. S. ; Lin, S. ; Markwalder, J.A. ; Mills, J.A. ; DeVito, J.A. ; TELEHA, C.A. ; Garlapati, V. ; Liu, C. ; Thompson, A. ; Trainor, J.L. ; D.L. Pompliano . Regulated expression of the Escherichia coli lepB gene as a tool for cellular testing of antimicrobial compounds that inhibit signal peptidase I in vitro. Antimicrobial Agents and Chemotherapy , v. 46, p. 3549-3554, 2002.

• BARBOSA, M. D. F. S. ; Ross, H.O. ; Hillman, M.C. ; Meade, R.P. ; Kurilla, M.G. ; D.L. Pompliano . A multi-target assay for inhibitors of membrane-associated steps of peptidoglycan biosynthesis. Analytical Biochemistry , v. 306, p. 17-22, 2002.

• BARBOSA, M. D. F. S. ; Yang, G. ; Fang, J. ; Kurilla, M.G. ; D.L. Pompliano . Development of a whole cell assay for peptidoglycan biosythesis inhibitors. Antimicrobial Agents and Chemotherapy , v. 46, p. 943-946, 2002.

• Stein, R.L. ; BARBOSA, M. D. F. S. ; Bruckner, R. . Kinetic and mechanistic studies of signal peptidase I from Escherichia coli. Biochemistry , v. 39, p. 7973-7983, 2000.

• BARBOSA, M. D. F. S. ; Barrat, F.J. ; Tchernev, V.T. ; Nguyen, Q.A. ; Mishra, V.S. ; Colman, S.D. ; Pastural, E. ; Dufourcq-Lagelouse, R. ; Holcombe, R.F. ; Wallace, M.R. ; Brandt, S.J. ; de Saint Basile, G. ; Kingsmore, S.F. . Identification of mutations in two major isoforms of the Chediak-Higashi syndrome gene in human and mouse. Human Molecular Genetics , v. 6, p. 1091-1098, 1997.

• Tchernev, V.T. ; BARBOSA, M. D. F. S. ; Detter, J.C. ; Patel, T.D. ; Wakeland, E.K. ; Gossler, A. ; Kingsmore, S.F. . Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering. Genomics (San Diego) , v. 40, p. 170-174, 1997.

• McMurtrie, E.B. ; BARBOSA, M. D. F. S. ; Zerial, M. ; Kingsmore, S.F. . Genetic mapping of Rab20 on mouse chromosome 6. Mammalian Genome , v. 8, p. 291-292, 1997.

• McMurtrie, E.B. ; BARBOSA, M. D. F. S. ; Zerial, M. ; Kingsmore, S.F. . Rab17 and rab18, small GTPases with specificity for polarized epithelial cells: genetic mapping in the mouse. Genomics (San Diego) , v. 45, p. 623-625, 1997.

• BARBOSA, M. D. F. S. ; Nguyen, Q.A. ; Tchernev, V.T. ; Ashley, J.A. ; Detter, J.C. ; Blaydes, S.M. ; Brandt, S.J. ; R.C. Hodgman ; Solari, R.C. ; Lovett, M. ; Kingsmore, S.F. . Identification of the homologous beige and Chediak-Higashi syndrome genes. Nature (London) , v. 382, p. 262-265, 1996.

• Kingsmore, S.F. ; BARBOSA, M. D. F. S. ; Tchernev, V.T. ; Lossie, A.C. ; Seldin, M.F. ; Holcombe, R.F. . Positional cloning of the Chediak-Higashi syndrome gene: genetic mapping of the beige locus on mouse chromosome 13. Journal of Investigative Medicine , v. 44, p. 454-461, 1996.

• Kingsmore, S.F. ; BARBOSA, M. D. F. S. ; Nguyen, Q.A. ; Ashley, J.A. ; Blaydes, S.M. ; Tchernev, V.T. ; Detter, J.C. ; Lovett, M. . Physical mapping of the beige critical region on mouse Chromomose 13. Mammalian Genome , v. 7, p. 773-775, 1996.

• BARBOSA, M. D. F. S. ; Wakeland, E.K. ; Zerial, M. ; Kingsmore, S.F. . Genetic mapping of the Rab5a and Rab5b genes on mouse Chromosomes 17 and 2, respectively. Mammalian Genome , v. 7, p. 166-167, 1996.

• BARBOSA, M. D. F. S. ; Johnson, S.A. ; Achey, K. ; Gutierrez, M.J. ; Wakeland, E.K. ; Kingsmore, S.F. . The Rab protein family: genetic mapping of six Rab genes in the mouse. Genomics (San Diego) , v. 30, p. 439-444, 1995.

• BARBOSA, M. D. F. S. ; Johnson, S.A. ; Achey, K. ; Gutierrez, M.J. ; Wakeland, E.K. ; Kingsmore, S.F. . Genetic mapping of the choroideremia-like, rab escort protein-2 gene on mouse Chromosome 1. Mammalian Genome , v. 6, p. 488-489, 1995.

• BARBOSA, M. D. F. S. ; Ingram, L.O. . Expression of the Zymomonas mobilis alcohol dehydrogenase II (adhB) and pyruvate decarboxylase (pdc) genes in Bacillus. Current Microbiology , v. 28, p. 279-282, 1994.

• BARBOSA, M. D. F. S. ; Yomano, L.P. ; Ingram, L.O. . Cloning, sequencing and expression of stress genes from the ethanol-producing bacterium Zymomonas mobilis: the groESL operon. Gene (Amsterdam) , v. 148, p. 51-57, 1994.

• Aldrich, H.C. ; MCDOWELL, L. ; BARBOSA, M. D. F. S. ; Yomano, L.P. ; Scopes, R.K. ; Ingram, L.O. . Immunocytochemical localization of glycolytic and fermentative enzymes in Zymomonas mobilis. Journal of Bacteriology , v. 174, p. 4504-4508, 1992.

• BARBOSA, M. D. F. S. ; Beck, M.J. ; Fein, J.E. ; Potts, D. ; L.O. Ingram . Efficient fermentation of pinus sp. acid hydrolysates by an ethanologenic strain of Escherichia coli. Applied and Environmental Microbiology , v. 58, p. 1382-1384, 1992.

• BARBOSA, M. D. F. S. ; Lee, H. . Plasma membrane Mg2+ -ATPase of Pachysolen tannophilus: characterization and role in alcohol tolerance. Applied and Environmental Microbiology , v. 57, p. 1880-1885, 1991.

• Roberto, I.C. ; Lacis, L.S. ; BARBOSA, M. D. F. S. ; Mancilha, I.M. . Utilization of sugar cane bagasse hemicellulosic hydrolysate by Pichia stipitis for the production of ethanol. Process Biochemistry , v. 26, p. 15-21, 1991.

• BARBOSA, M. D. F. S. ; Lee, H. ; Collins-Thompson, D. . Additive effects of alcohols, their acidic by-products and temperature on the yeast Pachysolen tannophilus. Applied and Environmental Microbiology , v. 56, p. 545-550, 1990.

• BARBOSA, M. D. F. S. ; Lee, H. ; Schneider, H. ; Forsberg, C.W. . Temperature mediated changes of D-xylose metabolism in the yeast Pachysolen tannophilus. FEMS Microbiology Letters , v. 72, p. 35-40, 1990.

• Schneider, H. ; Lee, H. ; BARBOSA, M. D. F. S. ; Kubicek, C.P. ; James, A.P. . Physiological properties of a mutant of Pachysolen tannophilus deficient in NADPH-dependent D-xylose reductase. Applied and Environmental Microbiology , v. 55, p. 2877-2881, 1989.

• BARBOSA, M. D. F. S. ; de Medeiros, M.B ; Mancilha, I.M. ; Schneider, H. ; Lee, H. . Screening of yeasts for production of xylitol from D-xylose and some factors which affect xylitol yield in Candida guilliermondii. Journal of Industrial Microbiology , v. 3, p. 241-251, 1988.

• Lee, H. ; Atkin, A.L. ; BARBOSA, M. D. F. S. ; Dorscheid, D.R. ; Schneider, H. . Effect of biotin limitation on the conversion of xylose to ethanol and xylitol by Pachysolen tannophilus and Candida guilliermondii. Enzyme and Microbial Technology , v. 10, p. 81-84, 1988.

• Lee, H. ; Biely, P. ; Latta, R.K. ; BARBOSA, M. D. F. S. ; Schneider, H. . Utililation of xylan by yeasts and its conversion to ethanol by Pichia stipitis strains. Applied and Environmental Microbiology , v. 52, p. 320-324, 1986.

• BARBOSA, M. D. F. S. ; Silva, D.O. ; Pinheiro, A.D.R. ; Guimaraes, W.V. ; Borges, A.C. . Production of beta-D-galactosidase from Kluyveromyces fragilis grown on cheese whey. Journal of Dairy Science , v. 68, p. 1618-1623, 1985.

• BARBOSA, M. D. F. S. . Rational development of a pre-clinical immunogenicity-testing platform.. 2006. (Apresentação de Trabalho/Conferência ou palestra).

• BARBOSA, M. D. F. S. . Strategies for the rational development of a pre-clinical immunogenicity-testing platform. 2006. (Apresentação de Trabalho/Conferência ou palestra).

• BARBOSA, M. D. F. S. . Exploiting Clinical Data for the Rational Development of a Pre-Clinical Immunogenicity Testing Platform: IFN-beta as a Case Study. 2006. (Apresentação de Trabalho/Conferência ou palestra).

• BARBOSA, M. D. F. S. . Practical considerations for an immunogenicity assessment strategy. 2005. (Apresentação de Trabalho/Conferência ou palestra).

• BARBOSA, M. D. F. S. . Clinical link between MHC class II haplotype and immunogenicity of a therapeutic protein. 2005. (Apresentação de Trabalho/Conferência ou palestra).

• BARBOSA, M. D. F. S. . Testing protein immunogenicity with ex vivo T-cell assays. 2005. (Apresentação de Trabalho/Conferência ou palestra).

• BARBOSA, M. D. F. S. . Factors involved in immunogenicity of therapeutic proteins: implications for in silico predictions, rational protein design and selection of assays for pre-clinical screening. 2005. (Apresentação de Trabalho/Conferência ou palestra).

• BARBOSA, M. D. F. S. ; Chamberlain, Aaron K. ; Desjarlais, John, R. . Optimized proteins that target Ep-CAM 2009 (US Patent number 7557190).

• Marshall, S.A. ; BARBOSA, M. D. F. S. . (WO/2005/014641) CILIARY NEUROTROPHIC FACTOR VARIANTS 2004 ((WO/2005/014641) Patent application).

• Kingsmore, S.F. ; BARBOSA, M. D. F. S. . (WO/1997/028262) LYST1 AND LYST2 GENE COMPOSITIONS AND METHODS OF USE 1997 (Patent application).

• L.O. Ingram ; BARBOSA, M. D. F. S. . (US Patent number 5,482,846) Ethanol production in Gram-positive microbes 1996 (US Patent number 5,482,846).