Manuel Soto Alvarez

Idiomas

Áreas de atuação

Produções bibliográficas

• 2016 LAGE, DANIELA P. ; DUARTE, MARIANA C. ; CARVALHO, ANA MARIA R.S. ; COSTA, LOURENA E. ; MENDES, TIAGO A.O. ; VALE, DANNIELE L. ; MENEZES-SOUZA, DANIEL ; ROATT, BRUNO M. ; TAVARES, CARLOS A.P. ; SOTO, MANUEL ; COELHO, EDUARDO A.F. . A recombinant fusion protein displaying murine and human MHC class I- and II-specific epitopes protects against Leishmania amazonensis infection. CELLULAR IMMUNOLOGY , v. 313, p. 32, 2016.

• IBORRA, SALVADOR ; MARTÍNEZ-LÓPEZ, MARÍA ; CUETO, FRANCISCO J. ; CONDE-GARROSA, RUTH ; DEL FRESNO, CARLOS ; IZQUIERDO, HELENA M. ; ABRAM, CLARE L. ; MORI, DAIKI ; CAMPOS-MARTÍN, YOLANDA ; REGUERA, ROSA MARÍA ; KEMP, BENJAMIN ; YAMASAKI, SHO ; ROBINSON, MATTHEW J. ; SOTO, MANUEL ; LOWELL, CLIFFORD A. ; SANCHO, DAVID . Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection. IMMUNITY , v. 45, p. 788-801, 2016.

• DUARTE, MARIANA COSTA ; LAGE, DANIELA PAGLIARA ; MARTINS, VÍVIAN TAMIETTI ; CHÁVEZ-FUMAGALLI, MIGUEL ANGEL ; ROATT, BRUNO MENDES ; MENEZES-SOUZA, DANIEL ; GOULART, LUIZ RICARDO ; SOTO, MANUEL ; TAVARES, CARLOS ALBERTO PEREIRA ; COELHO, EDUARDO ANTONIO FERRAZ . Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis. SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL. REVISTA , v. 49, p. 398-407, 2016.

• MARTINS, VÍVIAN T. ; DUARTE, MARIANA C. ; LAGE, DANIELA P. ; COSTA, LOURENA E. ; CARVALHO, ANA MARIA R. S. ; MENDES, TIAGO A. O. ; ROATT, BRUNO M. ; MENEZES-SOUZA, DANIEL ; SOTO, MANUEL ; COELHO, EDUARDO A. F. . A recombinant chimeric protein composed by human and mice-specific CD4 + and CD8 + T cell epitopes protects against visceral leishmaniasis. PARASITE IMMUNOLOGY , v. 39, p. e12359, 2016.

• DUARTE, MARIANA C. ; TAVARES, GRASIELE S.V. ; VALADARES, DIOGO G. ; LAGE, DANIELA P. ; RIBEIRO, TATIANA G. ; LAGE, LETÍCIA M.R. ; RODRIGUES, MARCELLA R. ; FARACO, ANDRÉ A.G. ; SOTO, MANUEL ; DA SILVA, EDUARDO S. ; CHÁVEZ FUMAGALLI, MIGUEL A. ; TAVARES, CARLOS A.P. ; LEITE, JOÃO PAULO V. ; OLIVEIRA, JAMIL S. ; CASTILHO, RACHEL O. ; COELHO, EDUARDO A.F. . Antileishmanial activity and mechanism of action from a purified fraction of Zingiber officinalis Roscoe against Leishmania amazonensis. EXPERIMENTAL PARASITOLOGY , v. 166, p. 21-28, 2016.

• MARTINS, VÍVIAN TAMIETTI ; LAGE, DANIELA PAGLIARA ; DUARTE, MARIANA COSTA ; COSTA, LOURENA EMANUELE ; GARDE, ESTHER ; RODRIGUES, MARCELLA REZENDE ; CHÁVEZ-FUMAGALLI, MIGUEL ANGEL ; MENEZES-SOUZA, DANIEL ; ROATT, BRUNO MENDES ; TAVARES, CARLOS ALBERTO PEREIRA ; SOTO, MANUEL ; COELHO, EDUARDO ANTONIO FERRAZ . A new Leishmania-specific hypothetical protein, LiHyT, used as a vaccine antigen against visceral leishmaniasis. ACTA TROPICA , v. 154, p. 73-81, 2016.

• COELHO, EDUARDO ANTONIO FERRAZ ; COSTA, LOURENA EMANUELE ; LAGE, DANIELA PAGLIARA ; MARTINS, VÍVIAN TAMIETTI ; GARDE, ESTHER ; DE JESUS PEREIRA, NATHÁLIA CRISTINA ; LOPES, ELIANE GONÇALVES PAIVA ; BORGES, LUIZ FELIPE NUNES MENEZES ; DUARTE, MARIANA COSTA ; MENEZES-SOUZA, DANIEL ; DE MAGALHÃES-SOARES, DANIELLE FERREIRA ; CHÁVEZ-FUMAGALLI, MIGUEL ANGEL ; SOTO, MANUEL ; TAVARES, CARLOS ALBERTO PEREIRA . Evaluation of two recombinant Leishmania proteins identified by an immunoproteomic approach as tools for the serodiagnosis of canine visceral and human tegumentary leishmaniasis. VETERINARY PARASITOLOGY , v. 215, p. 63-71, 2015.

• LAGE, DANIELA PAGLIARA ; MARTINS, VÍVIAN TAMIETTI ; DUARTE, MARIANA COSTA ; GARDE, ESTHER ; CHÁVEZ-FUMAGALLI, MIGUEL ANGEL ; MENEZES-SOUZA, DANIEL ; ROATT, BRUNO MENDES ; TAVARES, CARLOS ALBERTO PEREIRA ; SOTO, MANUEL ; COELHO, EDUARDO ANTONIO FERRAZ . Prophylactic properties of a Leishmania -specific hypothetical protein in a murine model of visceral leishmaniasis. PARASITE IMMUNOLOGY , v. 37, p. n/a-n/a, 2015.

• DUARTE, MARIANA C. ; PIMENTA, DANIEL C. ; MENEZES-SOUZA, DANIEL ; MAGALHÃES, RUBENS D. M. ; DINIZ, JOÃO L. C. P. ; COSTA, LOURENA E. ; CHÁVEZ-FUMAGALLI, MIGUEL A. ; LAGE, PAULA S. ; BARTHOLOMEU, DANIELA C. ; ALVES, MARIA JULIA M. ; FERNANDES, ANA PAULA ; SOTO, MANUEL ; TAVARES, CARLOS A. P. ; GONÇALVES, DENISE U. ; ROCHA, MANOEL O. C. ; COELHO, EDUARDO A. F. . Proteins Selected in Leishmania (Viannia) braziliensis by an Immunoproteomic Approach with Potential Serodiagnosis Applications for Tegumentary Leishmaniasis. Clinical and Vaccine Immunology , v. 22, p. 1187-1196, 2015.

• GUERRA-PÉREZ, NATALIA ; RAMOS, EDURNE ; GARCÍA-HERNÁNDEZ, MARTA ; PINTO, CELIA ; SOTO, MANUEL ; MARTÍN, M. ELENA ; GONZÁLEZ, VÍCTOR M. . Molecular and Functional Characterization of ssDNA Aptamers that Specifically Bind Leishmania infantum PABP. PLoS One , v. 10, p. e0140048, 2015.

• MARTINS, VIVIAN TAMIETTI ; CHÁVEZ-FUMAGALLI, MIGUEL ANGEL ; LAGE, DANIELA PAGLIARA ; DUARTE, MARIANA COSTA ; GARDE, ESTHER ; COSTA, LOURENA EMANUELE ; SILVA, VIVIANE GOMES DA ; OLIVEIRA, JAMIL SILVANO ; MAGALHÃES-SOARES, DANIELLE FERREIRA DE ; TEIXEIRA, SANTUZA MARIA RIBEIRO ; FERNANDES, ANA PAULA ; SOTO, MANUEL ; TAVARES, CARLOS ALBERTO PEREIRA ; COELHO, EDUARDO ANTONIO FERRAZ . Antigenicity, Immunogenicity and Protective Efficacy of Three Proteins Expressed in the Promastigote and Amastigote Stages of Leishmania infantum against Visceral Leishmaniasis. PLoS One , v. 10, p. e0137683, 2015.

• PINEDA, MIGUEL A. ; CUERVO, HENAR ; FRESNO, MANUEL ; SOTO, MANUEL ; BONAY, PEDRO . Lack of Galectin-3 Prevents Cardiac Fibrosis and Effective Immune Responses in a Murine Model of Infection. JOURNAL OF INFECTIOUS DISEASES , v. 212, p. 1160-1171, 2015.

• COELHO, EDUARDO ANTONIO FERRAZ ; CHÁVEZ-FUMAGALLI, MIGUEL ANGEL ; COSTA, LOURENA EMANUELE ; TAVARES, CARLOS ALBERTO PEREIRA ; SOTO, MANUEL ; GOULART, LUIZ RICARDO . Theranostic applications of phage display to control leishmaniasis: selection of biomarkers for serodiagnostics, vaccination, and immunotherapy. SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL. REVISTA , v. 48, p. 370-379, 2015.

• CHÁVEZ-FUMAGALLI, MIGUEL ANGEL ; RIBEIRO, TATIANA GOMES ; CASTILHO, RACHEL OLIVEIRA ; FERNANDES, SIMONE ODÍLIA ANTUNES ; CARDOSO, VALBERT NASCIMENTO ; COELHO, CECÍLIA STEINBERG PERILO ; MENDONÇA, DÉBORA VASCONCELOS COSTA ; SOTO, MANUEL ; TAVARES, CARLOS ALBERTO PEREIRA ; FARACO, ANDRÉ AUGUSTO GOMES ; COELHO, EDUARDO ANTONIO FERRAZ . New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment. SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL. REVISTA , v. 48, p. 235-242, 2015.

• MARTINS, VIVIAN T. ; DUARTE, MARIANA C. ; CHÁVEZ-FUMAGALLI, MIGUEL A. ; MENEZES-SOUZA, DANIEL ; COELHO, CECÍLIA S. P. ; DE MAGALHÃES-SOARES, DANIELLE F. ; FERNANDES, ANA PAULA ; SOTO, MANUEL ; TAVARES, CARLOS A. P. ; COELHO, EDUARDO A. F. . A Leishmania-specific hypothetical protein expressed in both promastigote and amastigote stages of Leishmania infantum employed for the serodiagnosis of, and as a vaccine candidate against, visceral leishmaniasis. Parasites & Vectors , v. 8, p. 363, 2015.

• SOTO, MANUEL ; CORVO, LAURA ; GARDE, ESTHER ; RAMÍREZ, LAURA ; INIESTA, VIRGINIA ; BONAY, PEDRO ; GÓMEZ-NIETO, CARLOS ; GONZÁLEZ, VÍCTOR M. ; MARTÍN, M. ELENA ; ALONSO, CARLOS ; COELHO, EDUARDO A. F. ; BARRAL, ALDINA ; BARRAL-NETTO, MANOEL ; IBORRA, SALVADOR . Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice. PLoS Neglected Tropical Diseases , v. 9, p. e0003751, 2015.

• DE JESUS PEREIRA, NATHÁLIA CRISTINA ; RÉGIS, WILIAM CÉSAR BENTO ; COSTA, LOURENA EMANUELE ; DE OLIVEIRA, JAMIL SILVANO ; DA SILVA, ALANNA GOMES ; MARTINS, VIVIAN TAMIETTI ; DUARTE, MARIANA COSTA ; DE SOUZA, JOSÉ ROBERTO RODRIGUES ; LAGE, PAULA SOUSA ; SCHNEIDER, MÔNICA SANTOS ; MELO, MARIA NORMA ; SOTO, MANUEL ; SOARES, SANDRA AGUIAR ; TAVARES, CARLOS ALBERTO PEREIRA ; CHÁVEZ-FUMAGALLI, MIGUEL ANGEL ; COELHO, EDUARDO ANTONIO FERRAZ . Evaluation of adjuvant activity of fractions derived from agaricus blazei, when in association with the recombinant LiHyp1 protein, to protect against visceral leishmaniasis. EXPERIMENTAL PARASITOLOGY , v. 153, p. 180, 2015.

• PEREIRA, LAIS ; ABBEHUSEN, MELISSA ; TEIXEIRA, CLARISSA ; CUNHA, JUREMA ; NASCIMENTO, IVAN P. ; FUKUTANI, KYIOSHI ; DOS-SANTOS, WASHINGTON ; BARRAL, ALDINA ; DE OLIVEIRA, CAMILA INDIANI ; BARRAL-NETTO, MANOEL ; SOTO, MANOEL ; BRODSKYN, CLÁUDIA IDA . Vaccination with Leishmania infantum Acidic Ribosomal P0 but Not with Nucleosomal Histones Proteins Controls Leishmania infantum Infection in Hamsters. PLoS Neglected Tropical Diseases , v. 10, p. e0003490, 2015.

• PINEDA, M. A. ; CORVO, L. ; SOTO, M. ; FRESNO, M. ; BONAY, P. . Interactions of human galectins with Trypanosoma cruzi: Binding profile correlate with genetic clustering of lineages. GLYCOBIOLOGY , v. 25, p. 197-210, 2015.

• COELHO, EDUARDO ; RIBEIRO, TATIANA ; FUSCALDI, LEONARDO ; SANTOS, MARA ; DUARTE, MARIANA ; LAGE, PAULA ; MARTINS, VIVIAN ; COSTA, LOURENA ; DINIZ, SIMONE ; CARDOSO, VALBERT ; CASTILHO, RACHEL ; SOTO, MANUEL ; TAVARES, CARLOS ALBERTO ; FUMAGALLI, MIGUEL ; RIBEIRO, JUCARA ; FARACO, ANDRE . An optimized nanoparticle delivery system based on chitosan and chondroitin sulfate molecules reduces the toxicity of amphotericin B and is effective in treating tegumentary leishmaniasis. International Journal of Nanomedicine , v. 9, p. 5341, 2014.

• COSTA, LOURENA EMANUELE ; GOULART, LUIZ RICARDO ; PEREIRA, NATHÁLIA CRISTINA DE JESUS ; LIMA, MAYARA INGRID SOUSA ; DUARTE, MARIANA COSTA ; MARTINS, VIVIAN TAMIETTI ; LAGE, PAULA SOUSA ; MENEZES-SOUZA, DANIEL ; RIBEIRO, TATIANA GOMES ; MELO, MARIA NORMA ; FERNANDES, ANA PAULA ; SOTO, MANUEL ; TAVARES, CARLOS ALBERTO PEREIRA ; CHÁVEZ-FUMAGALLI, MIGUEL ANGEL ; COELHO, EDUARDO ANTONIO FERRAZ . Mimotope-Based Vaccines of Leishmania infantum Antigens and Their Protective Efficacy against Visceral Leishmaniasis. PLoS One , v. 9, p. e110014, 2014.

• MAGALHÃES, RUBENS D. M. ; DUARTE, MARIANA C. ; MATTOS, ELICIANE C. ; MARTINS, VIVIAN T. ; LAGE, PAULA S. ; CHÁVEZ-FUMAGALLI, MIGUEL A. ; LAGE, DANIELA P. ; MENEZES-SOUZA, DANIEL ; RÉGIS, WILIAM C. B. ; MANSO ALVES, MARIA J. ; SOTO, MANUEL ; TAVARES, CARLOS A. P. ; NAGEN, RONALDO A. P. ; COELHO, EDUARDO A. F. . Identification of Differentially Expressed Proteins from Leishmania amazonensis Associated with the Loss of Virulence of the Parasites. PLoS Neglected Tropical Diseases , v. 8, p. e2764, 2014.

• RAMIREZ, LAURA ; CORVO, LAURA ; DUARTE, MARIANA C ; CHÁVEZ-FUMAGALLI, MIGUEL A ; VALADARES, DIOGO G ; SANTOS, DIEGO M ; DE OLIVEIRA, CAMILA I ; ESCUTIA, MARTA R ; ALONSO, CARLOS ; BONAY, PEDRO ; TAVARES, CARLOS AP ; COELHO, EDUARDO AF ; SOTO, MANUEL . Cross-protective effect of a combined L5 plus L3 Leishmania major ribosomal protein based vaccine combined with a Th1 adjuvant in murine cutaneous and visceral leishmaniasis. Parasites & Vectors , v. 7, p. 3, 2014.

• COSTA, L. E. ; LIMA, M. I. S. ; CHAVEZ-FUMAGALLI, M. A. ; SOUZA, D. M. ; MARTINS, V. T. ; DUARTE, M. C. ; LAGE, P. S. ; LOPES, E. G. P. ; LAGE, D. P. ; RIBEIRO, T. G. ; ANDRADE, P. H. R. ; DE MAGALHAES SOARES, D. F. ; SOTO, M. ; TAVARES, C. A. P. ; GOULART, L. R. ; COELHO, E. A. F. . Subtractive phage display selection from canine visceral leishmaniasis identifies novel epitopes that mimic Leishmania infantum antigens with potential serodiagnosis applications. Clinical and Vaccine Immunology , v. 21, p. 96, 2014.

• INIESTA, VIRGINIA ; BELINCHÓN-LORENZO, SILVIA ; SOTO, MANUEL ; FERNÁNDEZ-COTRINA, JAVIER ; MUÑOZ-MADRID, RUBÉN ; MONROY, ISABEL ; BAZ, VICTORIA ; GÓMEZ-LUQUE, ADELA ; PAREJO, JUAN CARLOS ; ALONSO, CARLOS ; NIETO, LUIS CARLOS GÓMEZ . Detection and chronology of parasitic kinetoplast DNA presence in hair of experimental Leishmania major infected BALB/c mice by Real Time PCR. ACTA TROPICA , v. 128, p. 468-472, 2013.

• SANTOS, DIEGO M. ; CARNEIRO, MARCIA W. ; DE MOURA, TATIANA R. ; SOTO, MANUEL ; LUZ, NÍVEA F. ; PRATES, DEBORACI B. ; IRACHE, JUAN MANUEL ; BRODSKYN, CLAUDIA ; BARRAL, ALDINA ; BARRAL-NETTO, MANOEL ; ESPUELAS, SOCORRO ; BORGES, VALÉRIA M. ; DE OLIVEIRA, CAMILA I. . PLGA nanoparticles loaded with KMP-11 stimulate innate immunity and induce the killing of Leishmania. Nanomedicine-Nanotechnology Biology and Medicine , v. 9, p. 985-995, 2013.

• SOUZA, ANA PAULA ; SOTO, MANUEL ; COSTA, JACKSON M. L. ; BOAVENTURA, VIVIANE S. ; DE OLIVEIRA, CAMILA I. ; CRISTAL, JUQUELINE R. ; BARRAL-NETTO, MANOEL ; BARRAL, ALDINA . Towards a More Precise Serological Diagnosis of Human Tegumentary Leishmaniasis Using Leishmania Recombinant Proteins. PLoS One , v. 8, p. e66110, 2013.

• CHAVEZ-FUMAGALLI, M. A. ; MARTINS, V. T. ; TESTASICCA, M. C. S. ; LAGE, D. P. ; COSTA, L. E. ; LAGE, P. S. ; DUARTE, M. C. ; KER, H. G. ; RIBEIRO, T. G. ; CARVALHO, F. A. A. ; REGIS, W. C. B. ; DOS REIS, A. B. ; TAVARES, C. A. P. ; SOTO, M. ; FERNANDES, A. P. ; COELHO, E. A. F. . Sensitive and Specific Serodiagnosis of Leishmania infantum Infection in Dogs by Using Peptides Selected from Hypothetical Proteins Identified by an Immunoproteomic Approach. Clinical and Vaccine Immunology , v. 20, p. 835-841, 2013.

• MARTINS, VIVIAN T. ; CHÁVEZ-FUMAGALLI, MIGUEL A. ; COSTA, LOURENA E. ; MARTINS, ADRIANA M. C. C. ; LAGE, PAULA S. ; LAGE, DANIELA P. ; DUARTE, MARIANA C. ; VALADARES, DIOGO G. ; MAGALHÃES, RUBENS D. M. ; RIBEIRO, TATIANA G. ; NAGEN, RONALDO A. P. ; DAROCHA, WANDERSON D. ; RÉGIS, WILIAM C. B. ; SOTO, MANUEL ; COELHO, EDUARDO A. F. ; FERNANDES, ANA PAULA ; TAVARES, CARLOS A. P. . Antigenicity and Protective Efficacy of a Leishmania Amastigote-specific Protein, Member of the Super-oxygenase Family, against Visceral Leishmaniasis. PLoS Neglected Tropical Diseases , v. 7, p. e2148, 2013.

• RAMÍREZ, LAURA ; SANTOS, DIEGO M. ; SOUZA, ANA P. ; COELHO, EDUARDO A.F. ; BARRAL, ALDINA ; ALONSO, CARLOS ; ESCUTIA, MARTA R. ; BONAY, PEDRO ; DE OLIVEIRA, CAMILA I. ; SOTO, MANUEL . Evaluation of immune responses and analysis of the effect of vaccination of the Leishmania major recombinant ribosomal proteins L3 or L5 in two different murine models of cutaneous leishmaniasis. VACCINE , v. 31, p. 1312, 2013.

• BELINCHÓN-LORENZO, SILVIA ; INIESTA, VIRGINIA ; PAREJO, JUAN CARLOS ; FERNÁNDEZ-COTRINA, JAVIER ; MUÑOZ-MADRID, RUBÉN ; SOTO, MANUEL ; ALONSO, CARLOS ; GÓMEZ NIETO, LUIS CARLOS . Detection of Leishmania infantum kinetoplast minicircle DNA by Real Time PCR in hair of dogs with leishmaniosis. VETERINARY PARASITOLOGY , v. 192, p. 43-50, 2013.

• FERNÁNDEZ-COTRINA, J. ; INIESTA, V. ; BELINCHÓN-LORENZO, S. ; MUÑOZ-MADRID, R. ; SERRANO, F. ; PAREJO, J.C. ; GÓMEZ-GORDO, L. ; SOTO, M. ; ALONSO, C. ; GÓMEZ-NIETO, L.C. . Experimental model for reproduction of canine visceral leishmaniosis by Leishmania infantum. VETERINARY PARASITOLOGY , v. 192, p. 118-128, 2013.

• CARNEIRO, MARCIA W. ; SANTOS, DIEGO M. ; FUKUTANI, KIYOSHI F. ; CLARENCIO, JORGE ; MIRANDA, JOSE CARLOS ; BRODSKYN, CLAUDIA ; BARRAL, ALDINA ; BARRAL-NETTO, MANOEL ; SOTO, MANUEL ; DE OLIVEIRA, CAMILA I. . Vaccination with L. infantum chagasi Nucleosomal Histones Confers Protection against New World Cutaneous Leishmaniasis Caused by Leishmania braziliensis. PLoS One , v. 7, p. e52296, 2012.

• VALADARES, DIOGO G. ; DUARTE, MARIANA C. ; RAMÍREZ, LAURA ; CHÁVEZ-FUMAGALLI, MIGUEL A. ; MARTINS, VIVIAN T. ; COSTA, LOURENA E. ; LAGE, PAULA S. ; RIBEIRO, TATIANA G. ; CASTILHO, RACHEL O. ; FERNANDES, ANA PAULA ; RÉGIS, WILIAM C.B. ; SOTO, MANUEL ; TAVARES, CARLOS A.P. ; COELHO, EDUARDO A.F. . Prophylactic or therapeutic administration of Agaricus blazei Murill is effective in treatment of murine visceral leishmaniasis. EXPERIMENTAL PARASITOLOGY , v. 132, p. 228-236, 2012.

• VALADARES, DIOGO G. ; DUARTE, MARIANA C. ; RAMÍREZ, LAURA ; CHÁVEZ-FUMAGALLI, MIGUEL A. ; LAGE, PAULA S. ; MARTINS, VIVIAN T. ; COSTA, LOURENA E. ; RIBEIRO, TATIANA G. ; RÉGIS, WILIAM C. B. ; SOTO, MANUEL ; FERNANDES, ANA PAULA ; TAVARES, CARLOS A. P. ; COELHO, EDUARDO A. F. . Therapeutic efficacy induced by the oral administration of Agaricus blazei Murill against Leishmania amazonensis. PARASITOLOGY RESEARCH , v. 111, p. 1807-1816, 2012.

• COELHO, VINICIO T. S. ; OLIVEIRA, JAMIL S. ; VALADARES, DIOGO G. ; CHÁVEZ-FUMAGALLI, MIGUEL A. ; DUARTE, MARIANA C. ; LAGE, PAULA S. ; SOTO, MANUEL ; SANTORO, MARCELO M. ; TAVARES, CARLOS A. P. ; FERNANDES, ANA PAULA ; COELHO, EDUARDO A. F. . Identification of Proteins in Promastigote and Amastigote-like Leishmania Using an Immunoproteomic Approach. PLoS Neglected Tropical Diseases , v. 6, p. e1430, 2012.

• OLIVEIRA, DULCILENE M. ; COSTA, MARIANA AMÁLIA F. ; CHAVEZ-FUMAGALLI, MIGUEL A. ; VALADARES, DIOGO G. ; DUARTE, MARIANA C. ; COSTA, LOURENA E. ; MARTINS, VIVIAN T. ; GOMES, ROSÂNGELA F. ; MELO, MARIA N. ; SOTO, MANUEL ; TAVARES, CARLOS ALBERTO P. ; COELHO, EDUARDO ANTONIO F. . Evaluation of parasitological and immunological parameters of Leishmania chagasi infection in BALB/c mice using different doses and routes of inoculation of parasites. PARASITOLOGY RESEARCH , v. 110, p. 1277-1285, 2012.

• ABÁNADES, DANIEL R. ; ARRUDA, LEONARDO V. ; ARRUDA, ELAINE S. ; PINTO, JOSÉ ROBERTO A. S. ; PALMA, MARIO S. ; AQUINO, DORLENE ; CALDAS, ARLENE J. ; SOTO, MANUEL ; BARRAL, ALDINA ; BARRAL-NETTO, MANOEL . Immunodominant Antigens of Leishmania chagasi Associated with Protection against Human Visceral Leishmaniasis. PLoS Neglected Tropical Diseases , v. 6, p. e1687, 2012.

• DA SILVA, ROBSON A.A. ; TAVARES, NATÁLIA M. ; COSTA, DIRCEU ; PITOMBO, MAIANA ; BARBOSA, LARISSA ; FUKUTANI, KYIOSHI ; MIRANDA, JOSE C. ; DE OLIVEIRA, CAMILA I. ; VALENZUELA, JESUS G. ; BARRAL, ALDINA ; SOTO, MANUEL ; BARRAL-NETTO, MANOEL ; BRODSKYN, CLÁUDIA . DNA vaccination with KMP11 and Lutzomyia longipalpis salivary protein protects hamsters against visceral leishmaniasis. ACTA TROPICA , v. 120, p. 185-190, 2011.

• CARRIÓN, JAVIER ; FOLGUEIRA, CRISTINA ; SOTO, MANUEL ; FRESNO, MANUEL ; REQUENA, JOSE M . Leishmania infantum HSP70-II null mutant as candidate vaccine against leishmaniasis: a preliminary evaluation. Parasites & Vectors , v. 4, p. 150, 2011.

• IBORRA, S. ; SOTO, M. ; STARK-AROEIRA, L. ; CASTELLANO, E. ; ALARCON, B. ; ALONSO, C. ; SANTOS, E. ; FERNANDEZ-MALAVE, E. . H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity. BLOOD , v. 117, p. 5102-5111, 2011.

• GUERRA, NATALIA ; VEGA-SENDINO, MARÍA ; PÉREZ-MORGADO, M. ISABEL ; RAMOS, EDURNE ; SOTO, MANUEL ; GONZALEZ, VÍCTOR M. ; MARTÍN, M. ELENA . Identification and functional characterization of a poly(A)-binding protein from ( PABP). FEBS LETTERS , v. 585, p. 193-198, 2011.

• CHÁVEZ-FUMAGALLI, MIGUEL A. ; COSTA, MARIANA A.F. ; OLIVEIRA, DULCILENE M. ; RAMÍREZ, LAURA ; COSTA, LOURENA E. ; DUARTE, MARIANA C. ; MARTINS, VIVIAN T. ; OLIVEIRA, JAMIL S. ; OLORTEGI, CARLOS C. ; BONAY, PEDRO ; ALONSO, CARLOS ; TAVARES, CARLOS A.P. ; SOTO, MANUEL ; COELHO, EDUARDO A.F. . Vaccination with the Leishmania infantum ribosomal proteins induces protection in BALB/c mice against Leishmania chagasi and Leishmania amazonensis challenge. MICROBES AND INFECTION , v. 12, p. 967-977, 2010.

• RAMOS, EDURNE ; MORENO, MIGUEL ; MARTÍN, M. ELENA ; SOTO, MANUEL ; GONZALEZ, VÍCTOR M. . Selection of H3-Binding ssDNA Aptamers. Oligonucleotides. (Larchmont, NY) , v. 20, p. 207-213, 2010.

• SOUZA, ANA PAULA ; ANDRADE, BRUNO BEZERRIL ; AQUINO, DORLENE ; ENTRINGER, PETTER ; MIRANDA, JOSÉ CARLOS ; ALCANTARA, RUAN ; RUIZ, DANIEL ; SOTO, MANUEL ; TEIXEIRA, CLARISSA R. ; VALENZUELA, JESUS G. ; DE OLIVEIRA, CAMILA INDIANI ; BRODSKYN, CLÁUDIA IDA ; BARRAL-NETTO, MANOEL ; BARRAL, ALDINA . Using Recombinant Proteins from Lutzomyia longipalpis Saliva to Estimate Human Vector Exposure in Visceral Leishmaniasis Endemic Areas. PLoS Neglected Tropical Diseases , v. 4, p. e649, 2010.

• RAMÍREZ, LAURA ; IBORRA, SALVADOR ; CORTÉS, JIMENA ; BONAY, PEDRO ; ALONSO, CARLOS ; BARRAL-NETTO, MANOEL ; SOTO, MANUEL . BALB/c Mice Vaccinated with Leishmania major Ribosomal Proteins Extracts Combined with CpG Oligodeoxynucleotides Become Resistant to Disease Caused by a Secondary Parasite Challenge. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY , v. 2010, p. 1-10, 2010.

• ABANADES, DANIEL R ; RAMÍREZ, LAURA ; IBORRA, SALVADOR ; SOTERIADOU, KETTY ; GONZÁLEZ, VICTOR M ; BONAY, PEDRO ; ALONSO, CARLOS ; SOTO, MANUEL . Key role of the 3' untranslated region in the cell cycle regulated expression of the Leishmania infantum histone H2A genes: minor synergistic effect of the 5' untranslated region. BMC MOLECULAR BIOLOGY , v. 10, p. 48, 2009.

• SMIRLIS, DESPINA ; BOLETI, HARALABIA ; GAITANOU, MARIA ; SOTO, MANUEL ; SOTERIADOU, KETTY . Ran-GTPase interacts at the nuclear rim with linker histone H1. BIOCHEMICAL JOURNAL , v. 424, p. 367-374, 2009.

• COELHO, E. A. F. ; RAMIREZ, L. ; COSTA, M. A. F. ; COELHO, V. T. S. ; MARTINS, V. T. ; CHAVEZ-FUMAGALLI, M. A. ; OLIVEIRA, D. M. ; TAVARES, C. A. P. ; BONAY, P. ; NIETO, C. G. ; ABANADES, D. R. ; ALONSO, C. ; SOTO, M. . Specific Serodiagnosis of Canine Visceral Leishmaniasis Using Leishmania Species Ribosomal Protein Extracts. Clinical and Vaccine Immunology , v. 16, p. 1774-1780, 2009.

• DE OLIVEIRA, CAMILA I. ; NASCIMENTO, IVAN P. ; BARRAL, ALDINA ; SOTO, MANUEL ; BARRAL-NETTO, MANOEL . Challenges and perspectives in vaccination against leishmaniasis. PARASITOLOGY INTERNATIONAL , v. 58, p. 319-324, 2009.

• CARCELÉN, J. ; INIESTA, V. ; FERNÁNDEZ-COTRINA, J. ; SERRANO, F. ; PAREJO, J.C. ; CORRALIZA, I. ; GALLARDO-SOLER, A. ; MARAÑÓN, F. ; SOTO, M. ; ALONSO, C. ; GÓMEZ-NIETO, C. . The Chimerical Multi-Component Q protein from Leishmania in the absence of adjuvant protects dogs against an experimental Leishmania infantum infection. VACCINE , v. 27, p. 5964-5973, 2009.

• IBORRA, S ; PARODY, N ; ABANADES, D ; BONAY, P ; PRATES, D ; NOVAIS, F ; BARRALNETTO, M ; ALONSO, C ; SOTO, M . Vaccination with the Leishmania major ribosomal proteins plus CpG oligodeoxynucleotides induces protection against experimental cutaneous leishmaniasis in mice. MICROBES AND INFECTION , v. 10, p. 1133-1141, 2008.

• INIESTA, VIRGINIA ; CORRALIZA, INÉS ; CARCELÉN, JESUALDO ; GÓMEZ GORDO, LUIS ; FERNÁNDEZ-COTRINA, JAVIER ; PAREJO, JUAN CARLOS ; CARRIÓN, JAVIER ; SOTO, MANUEL ; ALONSO, CARLOS ; GÓMEZ NIETO, CARLOS . Leishmania major infection in susceptible and resistant mice elicit a differential humoral response against a total soluble fraction and defined recombinant antigens of the parasite. PARASITOLOGY RESEARCH , v. 102, p. 887-893, 2008.

• IBORRA, S. ; ABÁNADES, D. R. ; PARODY, N. ; CARRIÓN, J. ; RISUEÑO, R. M. ; PINEDA, M. A. ; BONAY, P. ; ALONSO, C. ; SOTO, M. . The immunodominant T helper 2 (Th2) response elicited in BALB/c mice by the Leishmania LiP2a and LiP2b acidic ribosomal proteins cannot be reverted by strong Th1 inducers. CLINICAL AND EXPERIMENTAL IMMUNOLOGY , v. 150, p. 375-385, 2007.

• RAMOS, EDURNE ; PIÑEIRO, DAVID ; SOTO, MANUEL ; ABANADES, DANIEL R ; MARTÍN, M ELENA ; SALINAS, MATILDE ; GONZÁLEZ, VÍCTOR M . A DNA aptamer population specifically detects Leishmania infantum H2A antigen. LABORATORY INVESTIGATION , v. 87, p. 409, 2007.

• CARRION, J ; NIETO, A ; SOTO, M ; ALONSO, C . Adoptive transfer of dendritic cells pulsed with Leishmania infantum nucleosomal histones confers protection against cutaneous leishmaniosis in BALB/c mice. MICROBES AND INFECTION , v. 9, p. 735-743, 2007.

• CEPEDA, VICTORIA ; FUERTES, MIGUEL ; CASTILLA, JOSEFINA ; ALONSO, CARLOS ; QUEVEDO, CELIA ; SOTO, MANUAL ; PEREZ, JOSE . Poly(ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors in Cancer Chemotherapy. Recent Patents on Anti-Cancer Drug Discovery , v. 1, p. 39-53, 2006.

• PEREZ, JOSE ; SOTO, MANUEL ; QUEVEDO, CELIA ; ALONSO, CARLOS ; CEPEDA, VICTORIA ; FUERTES, MIGUEL ; NGUEWA, PAUL . Poly(ADP-ribose) Polymerase-1 Inhibitor 3-Aminobenzamide Enhances Apoptosis Induction by Platinum Complexes in Cisplatin-Resistant Tumor Cells. Medicinal Chemistry , v. 2, p. 47-53, 2006.

• CARRION, J. ; NIETO, A. ; IBORRA, S. ; INIESTA, V. ; SOTO, M. ; FOLGUEIRA, C. ; ABANADES, D. R. ; REQUENA, J. M. ; ALONSO, C. . Immunohistological features of visceral leishmaniasis in BALB/c mice. PARASITE IMMUNOLOGY , v. 28, p. 173-183, 2006.

• PASSOS, S. ; CARVALHO, L. P. ; ORGE, G. ; JERONIMO, S. M. ; BEZERRA, G. ; SOTO, M. ; ALONSO, C. ; CARVALHO, E. M. . Recombinant Leishmania Antigens for Serodiagnosis of Visceral Leishmaniasis. Clinical and Vaccine Immunology , v. 12, p. 1164-1167, 2005.

• QUIJADA, LUIS ; SOTO, MANUEL ; REQUENA, JOSÉ M. . Genomic DNA macroarrays as a tool for analysis of gene expression in Leishmania. EXPERIMENTAL PARASITOLOGY , v. 111, p. 64-70, 2005.

• IBORRA, S. ; CARRION, J. ; ANDERSON, C. ; ALONSO, C. ; SACKS, D. ; SOTO, M. . Vaccination with the Leishmania infantum Acidic Ribosomal P0 Protein plus CpG Oligodeoxynucleotides Induces Protection against Cutaneous Leishmaniasis in C57BL/6 Mice but Does Not Prevent Progressive Disease in BALB/c Mice. INFECTION AND IMMUNITY , v. 73, p. 5842-5852, 2005.

• CARVALHO, L. P. ; PASSOS, S. ; DUTRA, W. O. ; SOTO, M. ; ALONSO, C. ; GOLLOB, K. J. ; CARVALHO, E. M. ; RIBEIRO DE JESUS, A. . Effect of LACK and KMP11 on IFN-gamma Production by Peripheral Blood Mononuclear Cells from Cutaneous and Mucosal Leishmaniasis Patients. SCANDINAVIAN JOURNAL OF IMMUNOLOGY , v. 61, p. 337-342, 2005.

• REQUENA, JOSE M ; IBORRA, SALVADOR ; CARRIÓN, JAVIER ; ALONSO, CARLOS ; SOTO, MANUEL . Recent advances in vaccines for leishmaniasis. EXPERT OPINION ON BIOLOGICAL THERAPY , v. 4, p. 1505-1517, 2004.

• LARRETA, RUTH ; SOTO, MANUEL ; QUIJADA, LUIS ; FOLGUEIRA, CRISTINA ; ABANADES, DANIEL R ; ALONSO, CARLOS ; REQUENA, JOSE M . The expression of HSP83 genes in Leishmania infantum is affected by temperature and by stage-differentiation and is regulated at the levels of mRNA stability and translation. BMC MOLECULAR BIOLOGY , v. 5, p. 3, 2004.

• FUERTES, MIGUEL ANGEL ; PÉREZ, JOSÉ MANUEL ; SOTO, MANUEL ; MENÉNDEZ, MARGARITA ; ALONSO, CARLOS . Thermodynamic stability of the C-terminal domain of the human inducible heat shock protein 70. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS , v. 1699, p. 45-56, 2004.

• SOTO, MANUEL ; IBORRA, SALVADOR ; QUIJADA, LUIS ; FOLGUEIRA, CRISTINA ; ALONSO, CARLOS ; REQUENA, JOSE M. . Cell-cycle-dependent translation of histone mRNAs is the key control point for regulation of histone biosynthesis in Leishmania infantum. BIOCHEMICAL JOURNAL , v. 379, p. 617-625, 2004.

• PARODY, N. ; SOTO, M. ; REQUENA, J. M. ; ALONSO, C. . Adjuvant guided polarization of the immune humoral response against a protective multicomponent antigenic protein (Q) from Leishmania infantum. A CpG + Q mix protects Balb/c mice from infection. PARASITE IMMUNOLOGY , v. 26, p. 283-293, 2004.

• IBORRA, S. ; SOTO, M. ; CARRION, J. ; NIETO, A. ; FERNANDEZ, E. ; ALONSO, C. ; REQUENA, J. M. . The Leishmania infantum Acidic Ribosomal Protein P0 Administered as a DNA Vaccine Confers Protective Immunity to Leishmania major Infection in BALB/c Mice. INFECTION AND IMMUNITY , v. 71, p. 6562-6572, 2003.

• QUIJADA, LUIS ; SOTO, MANUEL ; ALONSO, CARLOS ; REQUENA, JOSÉ M. . High-efficiency plating method for Leishmania infantum. MOLECULAR AND BIOCHEMICAL PARASITOLOGY , v. 130, p. 139-141, 2003.

• REQUENA, JOSE M. ; QUIJADA, LUIS ; SOTO, MANUEL ; ALONSO, CARLOS . Conserved nucleotides surrounding the trans-splicing acceptor site and the translation initiation codon in Leishmania genes. EXPERIMENTAL PARASITOLOGY , v. 103, p. 78-81, 2003.

• MOLANO, I. ; ALONSO, M.GARC''A ; MIRÓN, C. ; REDONDO, E. ; REQUENA, J.M. ; SOTO, M. ; NIETO, C.GÓMEZ ; ALONSO, C. . A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY , v. 92, p. 1-13, 2003.

• DE CARVALHO, LUCAS PEDREIRA ; SOTO, MANUEL ; JERÔNIMO, SELMA ; DONDJI, BLAISE ; BACELLAR, OLÍVIA ; LUZ, VIVIANE ; ORGE, GLÓRIA ORGE ; ALONSO, CARLOS ; JESUS, AMÉLIA R. ; CARVALHO, EDGAR M. . Characterization of the immune response to Leishmania infantum recombinant antigens. MICROBES AND INFECTION , v. 5, p. 7-12, 2003.

• REQUENA, JOSE M ; ALONSO, CARLOS ; SOTO, MANUEL . More panantigens in Leishmania. TRENDS IN PARASITOLOGY , v. 17, p. 64, 2001.

• SOTO, M. ; ALONSO, C. ; REQUENA, J. M. . The Leishmania infantum acidic ribosomal protein LiP2a induces a prominent humoral response in vivo and stimulates cell proliferation in vitro and interferon-gamma (IFN-gamma) production by murine splenocytes. CLINICAL AND EXPERIMENTAL IMMUNOLOGY , v. 122, p. 212-218, 2000.

• REQUENA, JOSE M ; SOTO, MANUEL ; DORIA, MAR''A D ; ALONSO, CARLOS . Immune and clinical parameters associated with Leishmania infantum infection in the golden hamster model. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY , v. 76, p. 269-281, 2000.

• REQUENA, JOSE MAR''A ; ALONSO, CARLOS ; SOTO, MANUEL . Evolutionarily Conserved Proteins as Prominent Immunogens during Leishmania Infections. Parasitology Today (Regular ed. Print) (Cessou em 2000. Cont. ISSN 1471-4922 Trends in Parasitology) , v. 16, p. 246-250, 2000.

• QUIJADA, LUIS ; SOTO, MANUEL ; ALONSO, CARLOS ; REQUENA, JOSE M. . Identification of a putative regulatory element in the 3--untranslated region that controls expression of HSP70 in Leishmania infantum. MOLECULAR AND BIOCHEMICAL PARASITOLOGY , v. 110, p. 79-91, 2000.

• SOTO, MANUEL ; QUIJADA, LUIS ; ALONSO, CARLOS ; REQUENA, JOSE M. . Histone synthesis in Leishmania infantum is tightly linked to DNA replication by a translational control. BIOCHEMICAL JOURNAL , v. 346, p. 99-105, 2000.

• LARRETA, RUTH ; SOTO, MANUEL ; ALONSO, CARLOS ; REQUENA, JOSE M. . Leishmania infantum: Gene Cloning of the GRP94 Homologue, Its Expression as Recombinant Protein, and Analysis of Antigenicity. EXPERIMENTAL PARASITOLOGY , v. 96, p. 108-115, 2000.

• NIETO, C.G ; GARC''A-ALONSO, M ; REQUENA, J.M ; MIRÓN, C ; SOTO, M ; ALONSO, C ; NAVARRETE, I . Analysis of the humoral immune response against total and recombinant antigens of Leishmania infantum: correlation with disease progression in canine experimental leishmaniasis. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY , v. 67, p. 117-130, 1999.

• SOTO, M. ; REQUENA, J. M. ; QUIJADA, L. ; PEREZ, M. J. ; NIETO, C. G. ; GUZMAN, F. ; PATARROYO, M. E. ; ALONSO, C. . Antigenicity of the Leishmania infantum histones H2B and H4 during canine viscerocutaneous leishmaniasis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY , v. 115, p. 342-349, 1999.

• MARÍA REQUENA, JOSE ; SOTO, MANUEL ; QUIJADA, LUIS ; ALONSO, CARLOS . Genes and Chromosomes of Leishmania infantum. MEMORIAS DO INSTITUTO OSWALDO CRUZ , v. 92, p. 853-858, 1997.

• SOTO, MANUEL ; QUIJADA, LUIS ; ALONSO, CARLOS ; REQUENA, JOSE M . Molecular cloning and analysis of expression of the Leishmania infantum histone H4 genes1Note: Nucleotide sequence data reported in this paper have been submitted to the EMBL/GenBank/DDBJ databases with the accession numbers Y13915 (cDNA LiH4-1) and Y13916 (cDNA LiH4-2).1. MOLECULAR AND BIOCHEMICAL PARASITOLOGY , v. 90, p. 439-447, 1997.

• QUIJADA, L. ; SOTO, M. ; ALONSO, C. ; REQUENA, J. M. . Analysis of Post-transcriptional Regulation Operating on Transcription Products of the Tandemly Linked Leishmania infantum hsp70 Genes. JOURNAL OF BIOLOGICAL CHEMISTRY , v. 272, p. 4493-4499, 1997.

• REQUENA, JOSE M ; SOTO, MANUEL ; QUIJADA, LUIS ; CARRILLO, GRACIELA ; ALONSO, CARLOS . A region containing repeated elements is associated with transcriptional termination of Leishmania infantum ribosomal RNA genes1Note: Nucleotide sequences data reported in this paper are available in the EMBL, GenBank- and DDJB data bases under the accession number X99114.1. MOLECULAR AND BIOCHEMICAL PARASITOLOGY , v. 84, p. 101-110, 1997.

• SOTO, M. ; REQUENA, J. M. ; QUIJADA, L. ; GOMEZ, L. C. ; GUZMAN, F. ; PATARROYO, M. E. ; ALONSO, C. . Characterization of the antigenic determinants of the Leishmania infantum histone H3 recognized by antibodies elicited during canine visceral leishmaniasis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY , v. 106, p. 454-461, 1996.

• ANGEL, SERGIO O. ; REQUENA, JOSE M. ; SOTO, MANUEL ; CRIAGO, DOMINGO ; ALONSO, CARLOS . During canine leishmaniasis a protein belonging to the 83-kDa heat-shock protein family elicits a strong humoral response. ACTA TROPICA , v. 62, p. 45-56, 1996.

• QUIJADA, LUIS ; REQUENA, JOSE M. ; SOTO, MANUEL ; GÓMEZ, LUIS C. ; GUZMAN, FANNY ; PATARROYO, MANUEL E. ; ALONSO, CARLOS . Mapping of the linear antigenic determinants of the Leishmania infantum Hsp70 recognized by leishmaniasis sera. IMMUNOLOGY LETTERS , v. 52, p. 73-79, 1996.

• SOTO, MANUEL ; REQUENA, JOSE M. ; QUIJADA, LUIS ; GARCÍA, MERCEDES ; GUZMAN, FANNY ; PATARROYO, MANUEL E. ; ALONSO, CARLOS . Mapping of the linear antigenic determinants from the Leishmania infantum histone H2A recognized by sera from dogs with leishmaniasis. IMMUNOLOGY LETTERS , v. 48, p. 209-214, 1995.

• SOTO, M. ; REQUENA, J.M. ; QUIJADA, L. ; GUZMAN, F. ; PATARROYO, M.E. ; ALONSO, C. . Identification of the Leishmania infantum P0 ribosomal protein epitope in canine visceral leishmaniasis. IMMUNOLOGY LETTERS , v. 48, p. 23-28, 1995.

• SOTO, M ; REQUENA, J ; MOREIRA, D ; ALONSO, C . Assignment of genes to chromosomes: karyotype and ploidy. FEMS MICROBIOLOGY LETTERS , v. 129, p. 27-32, 1995.

• REQUENA, JOSE M. ; SOTO, MANUEL ; ALONSO, CARLOS . Bacteriophage λ: long-term stored stocks ready for lysis. TRENDS IN GENETICS , v. 9, p. 4, 1993.

• SOTO, MANUEL ; REQUENA, JOSE MARIA ; GOMEZ, LUIS CARLOS ; NAVARRETE, IGNACIO ; ALONSO, CARLOS . Molecular characterization of a Leishmania donovani infantum antigen identified as histone H2A. European Journal of Biochemistry (Print) (Cessou em 2004. Cont. ISSN 1742-464X The FEBS Journal (Print)) , v. 205, p. 211-216, 1992.

Projetos de pesquisa

• 2015 - 2016

  Desenvolvimento de sistemas rápidos, sensíveis e específicos para o diagnóstico da leishmaniose visceral canina?., Situação: Concluído; Natureza: Pesquisa. , Integrantes: Manuel Soto Alvarez - Coordenador / Mário Steindel - Integrante / Edmundo Carlos Grisard - Integrante / Ana Lúcia Abreu -Silva - Integrante / Camila Indiani de Oliveira - Integrante / Laura Ramírez García - Integrante / Alessandra Gutierrez de Oliveira - Integrante / Eliane Mattos Piranda - Integrante / Maria do Socorro Pires e Cruz - Integrante / Aldina Maria Prado Barral - Integrante., Financiador(es): Conselho Nacional de Desenvolvimento Científico e Tecnológico - Auxílio financeiro.

• 2015 - Atual

  Development of biotechnological tools for the prevention of leishmaniasis: from DNA vaccines to leishmanization with a genetically attenuated strain, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Manuel Soto Alvarez - Coordenador / Esther Garde - Integrante / Jose Carlos Solana - Integrante / Laura Ramirez - Integrante., Financiador(es): Instituto de Salud Carlos III - Auxílio financeiro.

• 2014 - 2016

  Development of pan-Leishmania vaccines based on antigenic proteins recognized by the sera from VL patients., Situação: Concluído; Natureza: Pesquisa. , Integrantes: Manuel Soto Alvarez - Coordenador / Manoel barral-Netto - Integrante., Financiador(es): Conselho Nacional de Desenvolvimento Científico e Tecnológico - Bolsa.

• 2012 - 2014

  Analysis of the antigenicity and immunogenicity of Leishmania translation initiation factors, Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (3) . , Integrantes: Manuel Soto Alvarez - Coordenador / Laura Ramírez García - Integrante / Maria Vega - Integrante / LIna Jimena Cortés Salinas - Integrante., Financiador(es): Instituto de Salud Carlos III - Auxílio financeiro.

• 2011 - 2012

  Analysis of the antigenic and immunogenic properties of Leishmania PABPs: Implications in diagnosis and vaccine design, Descrição: Analysis of the antigenic and immunogenic properties of Leishmania PABPs: Implications in diagnosis and vaccine design). 7ª Convocatoria Proyectos de Cooperación Interuniversitaria UAM-Santander con América Latina. 01-06-2011 to 30-05-2012. HEAD INVESTIGATOR: Manuel Soto. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Manuel Soto Alvarez - Coordenador / Manoel barral-Netto - Integrante., Financiador(es): Banco Santander - Espanha - Auxílio financeiro.

• 2009 - 2011

  Antigenicity and immunogenicity of Leishmania ribosomal proteins, Descrição: Antigenicity and immunogenicity of Leishmania ribosomal proteins) FIS PI080101 Instituto de Salud Carlos III. Ministerio de Ciencia e Innovación. 2009-11. HEAD INVESTIGATOR: Manuel Soto. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Manuel Soto Alvarez - Coordenador / Daniel Ruiz Abánades - Integrante / Carlos Alonso - Integrante., Financiador(es): Instituto de Salud Carlos III - Auxílio financeiro.

• 2008 - 2009

  Desarrollo de vacunas basadas en las proteínas ácidas ribosomales de Leishmania infantum., Situação: Concluído; Natureza: Pesquisa. , Integrantes: Manuel Soto Alvarez - Coordenador / Manoel barral-Netto - Integrante., Financiador(es): Agencia Espanhola de Cooperación Internacional - Auxílio financeiro.

• 2007 - 2011

  Mecanismos de Controle e immunoprofilaxia na leishmaniose, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Manuel Soto Alvarez - Integrante / Aldina Maria Prado Barral - Coordenador / Oscar Daniel Salomón - Integrante / Socorro Espuelas - Integrante / Jorge Arévalo - Integrante / Félix Tapia - Integrante / Gabriela Santos-Gomes - Integrante., Financiador(es): Programa Ibero-Americano de Ciencia y Tecnologia para el Desarrollo - Auxílio financeiro.