Igor Anatolievich Degterev

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Produções bibliográficas

• RODRIGUES, M. C. ; MUEHLMANN, L. A. ; LONGO, J. P. F. ; SILVA, R. C. ; GRAEBNER, I.B. ; Igor A Degterev ; LUCCI, C. M. ; AZEVEDO, R. B. ; GARCIA, M. P. . Photodynamic Therapy Based on Arrabidaea chica (Crajiru) Extract Nanoemulsion: In vitro Activity against Monolayers and Spheroids of Human Mammary Adenocarcinoma MCF-7 Cells. Journal of Nanomedicine & Nanotechnology , v. 6, p. 3-6, 2015.

• DAGHASTANLI, NASSER ALI ; DEGTEREV, I.A. ; Olivera G.B. ; Seabra, A.B. ; Oliveira, M.G. ; BORISSEVICH, IOURI EVGENIEVICH . Formation of cytotoxic intermediates in the course of photodecomposition of a nitroheterocyclic antiseptic quinifuryl. Journal of Photochemistry and Photobiology. A, Chemistry , v. 184, p. 98-104, 2006.

• DEGTEREV, I.A. ; ROCHA-E-SILVA, THOMAZ A.A ; RANTIN, FRANCISCO TADEU ; MATSUMURA-TUNDISI, JOSE EDUARDO ; TUNDISI, JOSE GALICIA ; MATSUMURA-TUNDISI, TAKAKO . Dynamic of cytochrome P450 inducers in polluted sites of São Paulo City reservoirs.. Ecotoxicology and Environmental Safety , v. 59, p. 109-115, 2004.

• DEGTEREV, I.A. ; ROCHA-E-SILVA, THOMAZ A.A., ; ROSSA, MARCELO MUNIZ ; RANTIN, FRANCISCO TADEU ; MATSUMURA-TUNDISI, TAKAKO ; TUNDISI, JOSE GALICIA . Comparison of liver mixed-function oxygenase and antioxidant enzymes of vertebrates living under neotropical conditions.. Comparative Biochemistry and Physiology , v. 137C, p. 155-165, 2004.

• DEGTEREV, I.A. ; BORISSEVITCH, I. E. ; DAGHASTANLI, N. A. ; TEDESCO, A. C. . Photocytotoxicity of Quinifuryl, a 5-Nitrofuran-Ethenyl-Quinoline antiseptic, towards P388 MouseLeukemia Cells .. Brazilian Journal of Medical & Biological Research, v. 37, p. 1873-1879, 2004.

• DEGTEREV, I.A. ; BORISSEVITCH, I. E. ; ROSSA, M. M. ; DAGHASTANLI, N. A. ; SELISTRE-DE-ARAUJO, H. ; TEDESCO, A. C. . Cytotoxicity of a nitroheterocyclic compounds, quinifuryl and nitracrine, towards leukaemic and normal cells on the dark and under illumination with visible light.. Journal of Photochemistry and Photobiology. B, Biology , v. 75, p. 27-32, 2004.

• DEGTEREV, I.A. ; BORISSEVITCH , IOURI EVGENIEVICH ; DAGHASTANLI, NASSER ALI . Primary processes of photodecomposition of 2-(5´)-nitro-2`-furanyl)ethenyl-4-{N-[4´-(N,N-diethylamino)- 1´-methylbutyl] carbamoyl} quinoline. Effect of oxygen and compound concentration.. Journal of Photochemistry and Photobiology. A, Chemistry , v. 159, p. 213-217, 2003.

• DEGTEREV, I.A. ; ROSSA, MARCELO MUNIZ ; ROCHA-E-SILVA, THOMAZ A.A. ; TERRUGGI, CRISTINA H.B. ; TEDESCO, ANTONIO CLAUDIO ; ARAUJO, HELOISA S.S ; BORISSEVICH, IOURI EVGENIEVICH . Comparison of the cytotoxicity of two nitroheterociclic drugs (NHCD) towards transformed and non-transformed cells.. Pharmacological Research , v. 48, p. 369-375, 2003.

• DEGTEREV, I.A. ; RANTIN, F. ; Rocha-e-Silva T.A.A ; B. Farley ; K.O. Nonaka ; H.S. Selistre-de-Araujo . Spectral characteristics of a compound altering cytochrome P450 spectra from vertebrate suggest that it is a functional protein.. Comparative Biochemistry and Physiology , Elsevier Press, v. 130C, p. 53-66, 2001.

• DEGTEREV, I.A. ; LEITÃO, M. ; AFFONSO, E. ; SILVA, M. ; MEIRELLES, N. ; RANTIN, F. ; VERCESI, A. ; JUNQUEIRA, V. . The liver monooxigenase system of Brazilian freshwater fish. Comparative Biochemistry and Physiology , Elsevier Science Inc., v. 126, p. 29-38, 2000.

• DEGTEREV, I.A. ; NOGUEIRA P.C.L., MARSAIOLI A.J., VERCESI A. E. . Microsomal metabolism of quinifuryl - a nitrofuryl-ethenyl-quinoline antiseptic possessing antitumor activity in vitro. European Journal Of Drug Metabolism And Pharmacokinetics, Geneva, v. 24, p. 15-22, 1999.

• DEGTEREV, I.A. ; MARQUES M.B., MEIRELLES N.C., TATARSKAYA N.K., ZAI . Metabolic oxidation of dipyridamole (DPM) in mouse liver microsomes. Oxidation Communications, Budapest, v. 21, p. 120-126, 1998.

• DEGTEREV, I.A. ; MEIRELLES N.C., MALHEIROS S.V.P., TATARSKAYA N.K. . Biological membranes and liposomes protect red blood cells (RBC) against trifluoperazine-induced lysis which is possibly due to non-metabolic drug oxidation by the membranes. Oxidation Communications, Budapest, v. 21, p. 127-133, 1998.

• DEGTEREV, I.A. ; BUZUKOV A.A., ZAIKOV G.E. . Ionol. Distribution in the organism, metabolism and biological effects. A review.. Oxidation Communications, Budapest, v. 20, p. 11-36, 1997.

• DEGTEREV, I.A. ; MEIRELLES N.C., MALHEIROS S.V.P., RUGGEIRO A.C., T . Erythrocyte stabilization against trifluoperazine-induced lysis afforded by mouse liver microsomes. Pharmaceutical Chemistry Journal , Moscow, v. 30, p. 9-12, 1996.

• DEGTEREV, I.A. ; 36. BUZUKOV A.A., IL'ASOVA V.B., TABAK M., MEIREL . An ESR and spectrophotometric study of the denitration of nitroheterocyclic drugs by liver homogenates and their metabolic consumption by liver microsomes from cytochrome P-450-induced mice.. Chemico-Biological Interactions, v. 100, p. 113-124, 1996.

• DEGTEREV, I.A. ; BUZUKOV A.A., ILIASOVA V.B., TABAK M., TATARSKAYA . Metabolic denitration of Quinifuryl and Nitracrine in mouse liver homogenate.. Pharmaceutical Chemistry Journal , Moscow, v. 29, p. 3-8, 1995.

• DEGTEREV, I.A. ; ILIASOVA V.B., BUZUKOV A.A., TABAK M. . On the mechanism of metabolic denitration of nitroheterocyclic compounds.. Biophysics, Moscow, v. 39, p. 219-225, 1994.

• DEGTEREV, I.A. ; 34. MEIRELLES N.C., MALHEIROS S.V.P., RUGGEIRO A. . Mouse liver microsomes (MLM) protect erythrocytes against trifluoperazine (TFP) induced and mechanical hemolysis which are Mouse liver microsomes (MLM) protect erythrocytes against trifluoperazine (TFP) induced and mechanical hemolysis which are due to TFP microsomal transformation and to the action of unidentified water-soluble microsomal factor (UF).. European Journal Of Drug Metabolism And Pharmacokinetics, Geneva, v. 19, p. 349-357, 1994.

• DEGTEREV, I.A. ; BUZUKOV A.A., ZAIKOV G.E. . Butylated Hydroxytoluene: pharmacokinetics, biological activity, metabolism and induction. A Review.. Journal Of Chemical And Biochemical Kinetics, New York, v. 2, p. 101-117, 1992.

• DEGTEREV, I.A. ; E, B. Y. . Biological and Phototransformation of 5-nitrofurilvinylquinoline derivatives. Interrelation with biological activity. Problems and possibilities of enhancing their therapeutic efficiency. A review.. Journal Of Chemical And Biochemical Kinetics, New York, v. 2, p. 259-265, 1992.

• DEGTEREV, I.A. ; BEKETOV B.N., BUZUKOV A.A., GUINOVKER A.G., TATARS . Induction of xenobiotic-metabolizing enzymes of mouse liver and embryo by metabolite of opistorkhys. Pharmaceutical Chemistry Journal , Moscow, v. 26, p. 26-30, 1992.

• DEGTEREV, I.A. ; POSTNIKOV L.M., BUZUKOV A.A. . Kinetic analysis of metabolic transformation of nitrohetrocyclic compounds. Pharmaceutical Chemistry Journal , Moscow, v. 25, p. 4-7, 1991.

• DEGTEREV, I.A. ; TATARSKAYA N.K., LEONOVA E.YU., BUZUKOV A.A., ZAIK . Effect of ascorbate and glutathione on microsomal metabolism of nitroheterocyclic drugs. Pharmaceutical Chemistry Journal , Moscow, v. 24, p. 22-26, 1990.

• DEGTEREV, I.A. ; TATARSKAYA N.K., BUZUKOV A.A. . Effect of catecholamines and relative structures on the microsomal metabolism of nitroheterocyclic drugs. Pharmaceutical Chemistry Journal , Moscow, v. 24, p. 26-29, 1990.

• DEGTEREV, I.A. ; BUZUKOV A.A., TATARSKAYA N.K., LEONOVA E.YU., SUKH . Metabolism of heterocyclic compounds in mouse liver microsomes. Pharmaceutical Chemistry Journal , Moscow, v. 24, p. 9-16, 1990.

• DEGTEREV, I.A. ; BUZUKOV A.A., LEONOVA E.YU., KONRADOV A.A. . Induction of mouse liver xenobiotic-metabolizing enzymes by BHT. Pharmaceutical Chemistry Journal , Moscow, v. 24, p. 16-19, 1990.

• DEGTEREV, I.A. ; VEROVSKIY V.N., SUKHOVA N.M., BUZUKOV A.A., LEONOV . Interrelation between structure, microsomal metabolizing activation, mouse toxicity, cytotoxicity and antitumor activity of heterocyclic- and nitroheterocyclic compounds. In vitro and in vivo study. Pharmaceutical Chemistry Journal , Moscow, v. 24, p. 20-24, 1990.

• DEGTEREV, I.A. ; SMIRNOV S.M., ZHURAV M.A., TATARSKAYA N.K., BORISE . Phototransformation of Quinifur. Nitroanion Radical Formation.. Chemical Physics , Moscow, v. 8, p. 17-23, 1989.

• DEGTEREV, I.A. ; SMIRNOV S.M., TATARSKAYA N.K., ZHURAV M.A., BORISE . Effect of Protonization on Spectral Features and Rate of Primary Processes of Quinifur Phototransformation. Chemical Physics , Moscow, v. 8, p. 1056-1059, 1989.

• DEGTEREV, I.A. ; TATARSKAYA N.K., ZHURAV M.A., SMIRNOV S.M., TARASO . Effect of Compound and Oxygen Concentration on Primary Processes of Quinifur Phototransformation.. Proceedings Of The Ussr Academy Of Sciences, Moscow, p. 804-809, 1989.

• DEGTEREV, I.A. ; BUZUKOV A.A., LEONOVA E.YU., ZAIKOV G.E. . Involving of cytochrome P-450 in adrenalin microsomal oxidation.. Pharmaceutical Chemistry Journal , Moscow, v. 23, p. 398-403, 1989.

• DEGTEREV, I.A. ; TATARSKAYA N.K., ZAIKOV G.E. . Kinetic investigation of nitrofuran microsomal biotransformation on the example of Quinifur.. Pharmaceutical Chemistry Journal , Moscow, v. 23, p. 530-537, 1989.

• DEGTEREV, I.A. ; TATARSKAYA N.K., ZAIKOV G.E. . Spectral investigation of Quinifur biotransformation mechanism. Pharmaceutical Chemistry Journal , Moscow, v. 23, p. 664-667, 1989.

• DEGTEREV, I.A. ; TATARSKAYA N.K., ZAIKOV G.E. . Effect of Ascorbic Acid and pH on Quinifur Biotransformation.. Pharmaceutical Chemistry Journal , v. 22, p. 912-918, 1988.

• DEGTEREV, I.A. ; 19. KUZMIN V.A., LEVIN P.P., BORISEVICH YU.E. . Triplet Excipleks of Nitrofuran Derivative with Aromatic Amines.. Proceedings Of The Ussr Academy Of Sciences, Moscow, p. 1510-1514, 1988.

• DEGTEREV, I.A. ; 16. BUZUKOV A.A., BRIN E.F., ZAIKOV G.E. . Kinetics and mechanism of initial stage of enzymatic transformation of radiosensitizer (nitrofuran derivative).. Chemical Physics , Moscow, v. 6, p. 356-360, 1987.

• DEGTEREV, I.A. ; VAKHNINA L.V., POPOV K.N., ZOZ N.N., BUZUKOV A.A. . Distribution of antitumor compound in plant tissues.. Proceedings Of The Ussr Academy Of Sciences, n.3, p. 473-476, 1987.

• DEGTEREV, I.A. ; BUZUKOV A.A., POPOV K.N., PAKHOMOV V.YU., SEREBRIA . On the mechanism of initial stage of BHT biotransformation.. Pharmaceutical Chemistry Journal , Moscow, v. 20, p. 784-787, 1986.

• DEGTEREV, I.A. ; BUZUKOV A.A., SHARF V.G., POPOV K.N., SEREBRIANIY . Comparative study of in vitro ledakrine metabolism in microsomes of EAC-cells and mouse liver. Pharmaceutical Chemistry Journal , v. 20, p. 412-417, 1986.

• DEGTEREV, I.A. ; KHODTSEV A.S., OSTROVSKIY M.A., ZAIKOV G.E. . Models of Autoimmune Diseases of Eye Retina. A review.. Human Physiology Rus, Moscow, v. 12, p. 100-109, 1986.

• DEGTEREV, I.A. ; SEREBRIANIY A.M., BUZUKOV A.A., POPOV K.N., FENTSO . In Vitro BHT metabolism in mouse and rat liver microsomes and EAC-cell microsomes.. Proceedings Of The Ussr Academy Of Sciences Biology, Moscow, n.5, p. 793-798, 1985.

• DEGTEREV, I.A. ; VORONINA S.S., TATARSKAYA N.K., SEREBRIANIY A.M., . Radiosensitizing activity and metabolism of some nitrofuran derivatives. 1. M-106.. Radiobiology Rus, v. 25, p. 748-751, 1985.

• DEGTEREV, I.A. ; GE, Z. . Ionol (BHT): Distribution in the organism, metabolism and biological effects. 1. Distribution in the organism and metabolism (Survey).. Pharmaceutical Chemistry Journal , Moscow, v. 19, p. 910-919, 1985.

• DEGTEREV, I.A. ; GE, Z. . Ionol (BHT): Distribution in the organism, metabolism and biological effects. 2. Biological effects of Ionol (Survey). Pharmaceutical Chemistry Journal , Moscow, v. 19, p. 1160-1168, 1985.

• DEGTEREV, I.A. ; Degterev, I.A> . Kinetics of BHT distribution in liver and tumor cells of EAT-bearing mice and intracellular distribution of H-labeled BHT. Experimental Oncology Rus, Kiev, n.1, p. 35-37, 1983.

• DEGTEREV, I.A. ; POPOV K.N., ZAIKOV G.E. . Kinetics of distribution of methyl damage introduced by C14 -nitrosourea to EAT-bearing mice.. Experimental Oncology Rus, Kiev, n.2, p. 54-58, 1982.

• DEGTEREV, I.A. ; Degterev, I.A> . Combined Adsorption of Albumin and g-Globuline on Polyethylene Surface.. Vysokomolecularnye Soedinenia J Polymer Sci Rus, Moscow, v. 22A, p. 519-521, 1980.

• DEGTEREV, I.A. ; POPOV K.N., BOROVKOVA N.K., TSEPALOVA N.A., ZAIKOV . Interaction of serum albumin with polymer hydrogels. Vysokomolecularnie Soiedinenia J Polymer Sci Rus, v. 22B, p. 1633-1636, 1980.

• DEGTEREV, I.A. ; JANOVSKIY M.A., ZHOMOV V.I., FRANK YU.A., ZAPOROZ . As is Concerned to Chemical Reaction in Chromatographic Regime.. Kinetica i Kataliz Kinetics And Catalysis Rus, Moscow, v. 17, p. 973-976, 1976.

• DEGTEREV, I.A. ; GONIKBERG E.M., UNUKOVITCH M.S., SHISHKOV A.V., F . Preparation of H3-Ribonuclease by Method of Tritium Activation at High Temperature and its Purification.. Reports Of The Ussr Academy Of Sciences, Moscow, v. 229, p. 112-115, 1976.

• DEGTEREV, I.A. ; JANOVSKIY M.A. , GATI D., ZHOMOV V.I., FRANK Y . Chromatographic Effect at Catalytic Isomerization of Olefins.. Magyar Chem Folyoirat Hungria, Budapest, n.11, p. 500-503, 1975.

• DEGTEREV, I.A. ; SHVEDCHIKOV A.P., DZANTIEV B.G. . Reactions of Excited Radicals. Photolysis of i-C3H7I and of Mixtures HI + C2H6 and HI + CH3 -CH2 =CH2. Khimia Vysokikh Energyi J High Energy Chemistry Rússia, Moscow, n.5, p. 162-163, 1972.

• DEGTEREV, I.A. ; SHVEDCHIKOV A.P., DZANTIEV B.G., FILATOV E.S. . Reactions of Hydrogen Atoms with Olefins. Photolysis of Mixtures HI with CF3 -CH2=CH2.. Proccedings Of The Moscow State University, Moscow, n.5, p. 596-597, 1972.

• DEGTEREV, I.A. ; G, S. A. P. D. B. . Reactions of Excited Propyl Radicals at the Photolysis of Iodine Propyl in Gas Phase. Khim Vys Energyi J Of High Energy Chemistry Rus, Moscow, n.4, p. 181-189, 1970.

• DEGTEREV, I.A. ; TODOROV I.N., ZAIKOV G.E., LEONOVA E.YU., TATARSKA . Bioactive Compounds: Biotransformation and Biological Action. 1. ed. New York: Nova Science Publishers, Inc., 1993. v. 1. 291p .

• DEGTEREV, I.A. ; MEIRELLES N.C., VERCESI A.E., DA SILLVA M.E.F. . Redox properties of hepatic cytochromes of Prochilodus scrofa (curimbata), a Brazilian freshwater fish. In: A.L. Val, V.M.F. Almeida e Val. (Org.). Biology of Tropical Fishes. 1ed.Manaus: INPA, 1999, v. , p. 253-261.

• DEGTEREV, I.A. ; GE, T. N. Z. . Kinetics and Mechanisms of Microsomal Metabolism of Nitroheterocyclic Compounds - 5-nitrofuran and 1-nitroacridine derivatives - and Relationship with Biological Activity of these Compounds.. In: Todorov I.N., Zaikov G.E., Degterev I.A. (Org.). Bioactive Compounds: Biotransformation and Biological Action. 1ed.New York: Nova Science Publishers. Inc., 1993, v. , p. 155-200.

• DEGTEREV, I.A. ; LEONOVA E.YU., TATARSKAYA N.K. . Mechanism of Microsomal Oxidation of Adrenaline. In: Todorov I.N., Zaikov G.E., Degterev I.A.. (Org.). Bioactive Compounds: Biotransformation and Biological Action. 1ed.New York: Nova Science Publishers, Inc., 1993, v. , p. 235-256.

• DEGTEREV, I.A. ; LEONOVA E.Y., ZAIKOV G.E. . Fundamental Possibilities of Modulating Microsomal Metabolism of Nitroheterocyclic Compounds - Prospects for Controlling their Therapeutic Effect. In: Todorov I.N., Zaikov G.E., Degterev I.. (Org.). Bioactive Compounds: Biotransformation and Biological Action. New York: Nova Science Publishers, Inc., 1993, v. , p. 201-234.

• DEGTEREV, I.A. ; 9. BUZUKOV A.A., ZAIKOV G.E. . Technic of an in vitro determination of BHT metabolites.. In: Burlakova E.B., Krugliakova K.E., Shishk. (Org.). Study of synthetic and natural antioxidants in vivo and in vitro. 1ed.Moscow: Nauka (Science Publs.), 1992, v. 1, p. 89-93.

• DEGTEREV, I.A. ; 10. BUZUKOV A.A., ZAIKOV G.E. . Preparation and purification of Tritium labeled BHT. Radioactivity measurements. In: Burlakova E.B., Krugliakova K.E., Shishk. (Org.). Study of synthetic and natural antioxidants in vivo and in vitro. 1ed.Moscow: Nauka (Science Publs.), 1992, v. , p. 103-104.

• DEGTEREV, I.A. ; AFFONSO E.G., DA SILVA M.E., MEIRELLES N.C., RANTI . Comparative study of the liver monooxigenase system of Brazilian fish. In: International Congress on the Biology of Fish, 1998, Baltimore. Special adaptations of tropical fish. Baltimore MD: Towson University, 1998. p. 101-105.

• DEGTEREV, I.A. ; BRIN E.F., BUZUKOV A.A., KOGARKO B.S. . Analyses of mechanism of enzyme-catalytic reaction inhibited by oxygen in the solution of an inverse problem.. In: Conferencia Unsteady-stable processes in catalysis, 1986, Novosibirsk. Unsteady-stable processes in catalysis. Novosibirsk: Institute of Catalysis of the USSR Academy of Sciences, 1986. p. 19-20.

• DEGTEREV, I.A. ; LEITÃO M.A.S., AFFONSO E.G., DA SILVA M.E.F, MEIRE . Peculiarities of adaptation of the neotropical freshwater fish: unusual enzyme(s) of the liver endoplasmic reticulum. FASEB Journal , Bethesda, v. 13, p. A1364, 1999.

• DEGTEREV, I.A. ; E. WAJNBERG, S.R.W. LOURO, A.E. VERCESI . Simultaneous formation of nitric oxide, superoxide anion, and peroxynitrite during microsomal metabolism of nitroheterocyclic antibiotics.. FASEB Journal , Bethesda, v. 13, p. A1457, 1999.

• DEGTEREV, I.A. ; MEIRELLES N.C., DA SILLVA M.E.F., GRIJALBA M.T., V . Peculiarities of hepatic cytochromes from Prochilodus scrofa ( a Brazilian freashwater fish). FASEB Journal , Bethesda, v. 11, p. A829., 1997.

• DEGTEREV, I.A. ; MALHEIROS S.V.P., MEIRELLES N.C., YUSHMANOV V.E., . Water soluble componenets of mouse liver cells protects red blood cells (RBC) against spontaneous and TFP-induced lysis. FASEB Journal , Bethesda, v. 11, p. Water, 1997.

• DEGTEREV, I.A. ; MARQUES M.B., MEIRELLES N.C. . Fluorescence study of dipyridamole (DIP) interaction with mouse liver microsomes (MLM) and red blood cells (RBC) ghosts. FASEB Journal , Bethesda, v. 11, p. A1310, 1997.

• DEGTEREV, I.A. ; GRIJALBA M.T., VERCESI A.E . Nitroheterocyclic antibiotics (NHCA) produce peroxynitrite during metabolism in liver microsomes. FASEB Journal , Bethesda, v. 11, p. A1310, 1997.

• DEGTEREV, I.A. ; MARQUES M.B., MEIRELLES N.C. . Metabolic and non-metabolic dipyridamole (DPM) interactions with biomembranes. Progress in Biophysics and Molecular Biology , Amsterdam, v. 65, p. 218-218, 1996.

• DEGTEREV, I.A. ; GRAEBNER, I.B. . EXTRATOS DE PLANTAS AMAZÔNICAS COMO PROMISSORAS FOTOSSENSIBILIZANTES PARA TERAPIA FOTODINÂMICA DO CANCRO E DE DOENÇAS INFECCIOSAS. 2013. (Apresentação de Trabalho/Congresso).

• DEGTEREV, I. A. ; NOVAS ABORDAGENS DA TERAPIA FOTODINÂMICA (TFD). PLANTAS AMAZÔNICAS COMO FONTE POTENCIAL DOS NOVOS FOTOSSENSIBILIZADORES PARA TFD.. 2011. (Apresentação de Trabalho/Outra).

• DEGTEREV, I. A. ; PLANTAS AMAZÔNICAS COMO FONTES DOS NOVOS FOTOSSENSIBILIZADORES PARA TERAPIA FOTODINÂMICA. 2011. (Apresentação de Trabalho/Congresso).

• DEGTEREV, I. A. ; ABORDAGEM FOTODINÂMICA NA TERAPIA DO CÂNCER. 2010. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; FOTOQUIMIOTERAPIA: PERSPECTIVAS DE USO DAS DROGAS NITROHETEROCICLICAS NO TRATAMENTO DE CÂNCER E DOENÇAS DE PELE. 2004. (Apresentação de Trabalho/Simpósio).

• DEGTEREV, I. A. ; FOTOQUIMIOTERAPIA ? PRINCÍPIOS BÁSICOS E ALGUMAS APLICAÇÕES. 2004. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; PRINCÍPIOS DE ENTREGA DIRIGIDA DAS DROGAS. APLICAÇÃO PARA AGENTES NITROHETEROCICLICOS. 2004. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; COMPOSTOS NITROHETEROCICLICOS ? UM NOVO CLASSE DE DROGAS PARA TERAPIA E FOTOTERAPIA DE CÂNCER. 2003. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; DROGAS NITROHETEROCICLICAS: INTERLIGAÇÕES ENTRE ESTRUTURA, REATIVIDADES BIO- E FOTOQUÍMICA, TOXICIDADE E AÇÃO TERAPÊUTICA. 2003. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; COMPOSTOS NITROHETEROCICLICOS ? UM NOVO CLASSE DE DROGAS PARA TERAPIA E FOTOTERAPIA DE CÂNCER. 2003. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; DROGAS NITROHETEROCÍCLICAS (DNHC). METABOLISMO, MECANISMOS DE TOXICIDADE E EFEITOS TERAPÊUTICOS, PERSPECTIVAS DAS ABORDAGENS NA MEDICINA ANTICANCERÍGENA. 2002. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; PROSPECTS OF TARGETED DELIVERY OF AND PHOTOCHEMISTRY WITH NITROHETEROCYCLIC DRUGS. 2001. (Apresentação de Trabalho/Congresso).

• DEGTEREV, I. A. ; MECANISMOS MOLECULARES DO METABOLISMO DE DROGAS E TOXINAS. CONEXÃO COM AÇÃO BIOLÓGICA. POSSIBILIDADES DE MODELAGENS QUÍMICAS. 1998. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; ANTIBIOTICS. MECHANISMS OF ACTION, TARGETED DELIVERY, PROBLEMS OF THERAPEUTIC ACTIVITY. 1998. (Apresentação de Trabalho/Congresso).

• DEGTEREV, I. A. ; METABOLISMO DE ANTIBIÓTICOS NITROHETEROCÍCLICAS E O MECANISMO DE SUAS AÇÕES CITOSTÁTICAS. 1997. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; POSSIBLE SOLUTION OF THE PROBLEMS OF THE NITRO GROUP-CONTAINING DRUGS EFFICACY MAY BE THEIR TARGETED DELIVERY. 1997. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; METABOLISMO E AÇÃO BIOLÓGICA DE DROGAS LIBERADORAS DE ÓXIDO NÍTRICO. 1995. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; DROGAS NITROHETEROCÍCLICAS: BIOTRANSFORMAÇÃO E AÇÃO BIOLÓGICA. 1995. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; BIOTRANSFORMAÇÃO E AÇÃO BIOLÓGICA DE DROGAS NITROHETEROCÍCLICAS. 1995. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; METABOLISMO E MECANISMO DE AÇÃO BIOLÓGICA DE DROGAS HETEROCÍCLICAS. PERSPECTIVAS DE SUAS REGULAÇÃO. 1993. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; BIOTRANSFORMAÇÃO DE COMPOSTOS BIOATIVOS. 1993. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; METABOLISMO DE FENOTIAZINAS E DERIVADOS DE NITROFURANO. 1993. (Apresentação de Trabalho/Seminário).

• DEGTEREV, I. A. ; INTERAÇÃO DE TRIFLUOPERAZINA COM ERITRÓCITOS. PROTEÇÃO MICROSSOMAL CONTRA HEMÓLISE. 1993. (Apresentação de Trabalho/Seminário).

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Projetos de pesquisa

• 2010 - 2012

  ESTRATÉGIAS PARA O DESENVOLVIMENTO DE NOVOS FÁRMACOS A PARTIR DE EXTRATOS DE PLANTAS AMAZÔNICAS, Descrição: Durante de realização do Projeto foi feita uma descoberta principal. É o que existem vários plantas amazônicas cujos extratos ou óleos absorvem e emitem a luz com energia ressonante com oxigênio molecular e que podem servir como fotossensibilizantes na Terapia Fotodinâmica. Está provado que óleo de Açaí e extratos de Crajiru e de folhas de Sucuuba efetivamente inibem crescimento de células cancerígenas em cultura (cânceres de mama e de boca) sob iluminação com a luz de laser vermelho. Estes extratos e óleo de Pataoá também inibiram crescimento de fungo Cândido albicans, e bactérias Staphylococcus aureus. Nos ambos os casos foram observados efeitos fotodinâmicos, i.e., a inibição foi bem mais pronunciado quando o sistema foi iluminado com a luz visível. Os experimentos in vivo mostraram alta efetividade de extratos de folhas de Sucuuba e de Crajiru, imobilizados em nanoemulções, como os potencias agentes antiinflamatórios. Foram elucidados os mecanismos dos efeitos fotodinâmicos observados usando as metodologias avançados e foi provado que os extratos (óleos) em questão, quando estão associados com as nanoemulções, entram em membranas celulares e ativam formação de espécies reativos de oxigênio (inclusive oxigênio singlete) e assim causa morte das células-alvos. Os dados obtidos mostram que apoptose é o provável mecanismo da morte de células cancerígenas causada por efeito fotodinâmico. Foi estabelecida a cooperação cientifica entre CCBN/UFAC e laboratórios de Microbiologia e de Imunologia da Unesp/Botucatu/SP, Departamento de Ecologia da Unesp/Rio Claro/SP, Instituto e com Departamento de Genética e Morfologia do ICB-UnB/DF. Com o material cientifico obtido nesta cooperação estão em preparação vários artigos científicos. Três estudantes da UFAC foram envolvidos em cooperação e fizeram estágios nestas Universidades adquirindo as habilidades de pesquisa cientifica na área de terapia fotodinâmica e nanomedicina. Três professores da UFAC estão participan. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (3) / Doutorado: (2) . , Integrantes: Igor Anatolievich Degterev - Coordenador / Fernando S. E. D. Viana de Faria - Integrante / Alexandrina Sartori - Integrante / Angela M.V. de Campos Suares - Integrante / Ilmar B. Graebner - Integrante., Financiador(es): Fundação de Tecnologia do Estado do Acre - Auxílio financeiro.