Danilo Fernandes Pires

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Participação em eventos

Produções bibliográficas

• PIRES, D. F. ; THOMASI, A. B. D. ; WOOD, A. ; CURRIE, P. . DESIGNING TOOLS FOR EXACERBATING DYSTROPHIC PHENOTYPES IN ZEBRAFISH. In: XXV Congresso Brasileiro de Engenharia Biomédica ? CBEB 2016, 2016, Foz do Iguaçu. ANAIS DO XXV CBEB - EDIÇÃO 2016, 2016. v. 1. p. 428-431.

• DELAVIA THOMASI, ANA BEATRIZ ; FERNANDES PIRES, DANILO . DESIGNING TOOLS FOR EXACERBATING DYSTROPHIC PHENOTYPES IN ZEBRAFISH. In: IX Simpósio de Engenharia Biomédica, 2016. v. 1.

Outras produções

Projetos de pesquisa

• 2016 - 2017

  Dispositivo eletrônico para correção de postura corporal em ambientes de estudo e trabalho, Descrição: A questão problema que envolve esse trabalho é a posição sentada de que a maioria das pessoas que frequentam a universidade permanece durante grande parte do dia. Entre os estudantes, geralmente jovens, o incômodo com a dor ou reflexos da incorreta posição ao sentar pode não ser sentida em curto prazo, mas se não observada corretamente, pode levar problemas mais graves em longo prazo e, consequentemente, a tratamentos mais demorados e custosos. Sendo assim, a proposta do desenvolvimento de um dispositivo eletrônico de baixo custo para monitorar a postura corporal em tempo real pode contribuir em trabalhos de pesquisa e extensão, pois, acelera a capitação e processamento dos dados. Além disso, pode ser utilizado em cursos de Fisioterapia, por exemplo, acelerando o processo de investigação da causa do desconforto, contribuindo com a melhora na qualidade de vida das pessoas dentro das universidades e demais locais de trabalho que demandam de seus funcionários, um longo período na posição sentada.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Danilo Fernandes Pires - Integrante / Celso Iwata Frison - Coordenador.

• 2015 - 2015

  Eye position signals in area V6A of the medial parietal cortex, Descrição: Research conducted over the last years has concluded that the medial part of posterior parietal cortex (PPC) plays an important role in controlling visually guided actions in both humans and macaque monkeys. In order to understand neural activity related to eye position, this project focused on decoding those signals from the posterior parietal cortex (PPC). This study was specifically in the V6A area, which is inside PPC and contains visual neurons and neurons modulated by eye and hand movements. The encoding of action in depth by V6A cells is a recent area of study in neurophysiology, and signals related to eye position in depth was addressed in this study. Recent evidence suggests the activity of V6A neurons is related to the gaze depth (i.e. where the eyes look in 3D). In V6A there are also signals related to the direction of the gaze and very often one neuron can have both signals, thus encoding spatial location in three dimensional space. Neuronal data from 192 neurons of the V6A area of two macaque monkeys from a previous study was used in this project. The aim of this study was to decode the eye position in 3D space from the ensemble activity of V6A neurons. A decoding algorithm (decoder), which is based in a decoder developed in a previous study of other parietal areas (Morris et al. 2013) was used. Some results obtained in this study indicate that we can obtain more accurate and precise results by decoding 3D eye position with a combination of a large number of neurons and a reasonable period of neural activity. The main results suggest that the population activity from V6A can give us an accurate and precise estimation of the position in 3D space. Therefore, the results give us a better understanding of how the brain works and give us a reasonable decoding algorithm of neural activity. Thus, in a future project of neural prosthesis for disabled patients, this decoder can be used to interpret the movement intentions and then, send those signals to a robotic prosthesis aid in order to make it moves as a real arm.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Danilo Fernandes Pires - Integrante / Konstantinos Chatzidimitrakis - Coordenador / Adam Morris - Integrante.

• 2014 - 2015

  Designing Tools for Exacerbating Dystrophic Phenotypes in Zebrafish, Descrição: Muscular dystrophy comprises a heterogeneous group of genetic disorders that are characterized by progressive and irreversible degeneration of muscle mass. Each of the disrupted genes distinctively affects the gene expression of one component of the two protein complexes in the muscle cell membrane: the Integrin-associated complex or Dystrophin-associated glycoprotein complex. The latter links the Extracellular Matrix to the muscle internal actin cytoskeleton, preventing fiber detachment during muscle contraction and its malfunction leads to many different diseases. One of them results from a deficiency in the glycosylation of dystroglycan, leading laminin to fail to bind. As an example, Candyfloss (LAMA2) Zebrafish has shown that fibers detach naturally as the result of basement membrane failure, therefore the hypothesis is that a similar phenomenon would be observed when exacerbated fish using a small electroshock. Fish are conventionally electrocuted using a S88 Grass Stimulator, which is not efficient, since it electrocutes only one fish at a time. For this reason, we conducted studies to develop a new device (Thomasi - Pires Lid, TPL) with a design inspired on a 48 well plate. Not only does the TPL enable the electrocution of 48 fish at a time, but it can also be used to image the fish and analyze the swimming assay on the ZebraBox, improving productivity.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) . , Integrantes: Danilo Fernandes Pires - Integrante / Alasdair Wood - Coordenador / Ana Beatriz Delavia Thomasi - Integrante / Peter Currie - Integrante.

• 2014 - 2014

  Integrating a humanoid robotic arm to studies of arm reaching movements in primates, Descrição: To develop a task for being apply into brain activities research by programming a robotic arm (UR5, from Universal Robots).. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Danilo Fernandes Pires - Integrante / Konstantinos Chatzidimitrakis - Coordenador / Adam Morris - Integrante.

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