Mauro Perretti

Possui graduação em Pharmaceutical Chemistry pela Università degli Studi di Firenze(1985), especialização em Pharmacology pela Università degli Studi di Firenze(1989) e doutorado em Faculty Of Science pela University of London(1996). Atualmente é professor titular da University of London e da William Harvey Research Institute. Tem experiência na área de Farmacologia.

Informações coletadas do Lattes em 10/11/2022

Acadêmico

Formação acadêmica

Doutorado em Faculty Of Science

1992 - 1996

University of London
Título: Lipocortin 1 and the control of neutrophil migration
Orientador: Roderick Flower
Grande área: Ciências Biológicas / Área: Farmacologia.

Especialização em Pharmacology

1986 - 1989

Università degli Studi di Firenze

Graduação em Pharmaceutical Chemistry

1979 - 1985

Università degli Studi di Firenze

Idiomas

Bandeira representando o idioma Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Bandeira representando o idioma Italiano

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Áreas de atuação

Grande área: Ciências Biológicas / Área: Farmacologia.

Participação em bancas

Aluno: Simon Jordan

PERRETTI, Mauro. Non-steroidal anti-inflammatory drugs: clinical issues. . 2001. Dissertação (Mestrado em Imperial College) - University of London.

Aluno: Joanne M Cousin

PERRETTI, Mauro. Effect of the protein phosphatase inhibitors, okadaic acid and calyculin A, on dexamethasone-mediated inhibition of neutrophil apoptosis. . 1998. Tese (Doutorado em Pós Graduação) - University Of Edinburgh.

Orientou

Patrícia Regina Soares de Souza

Papel do receptor GPR40 na artrite reumatoide; Início: 2013; Tese (Doutorado em Non Clinical PhD) - William Harvey Research Institute; (Orientador);

Simon Yona

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms; ; 2003; 0 f; Tese (Doutorado em Faculty Of Science) - University of London,; Orientador: Mauro Perretti;

Bristi Chatterjee

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms; ; 2003; 0 f; Tese (Doutorado em Faculty Of Science) - University of London,; Orientador: Mauro Perretti;

Maria Carollo

Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1alpha and MCP-1; ; 2001; 0 f; Tese (Doutorado em Faculty Of Science) - University of London,; Orientador: Mauro Perretti;

Stephen J Getting

MC3-R as a novel target for antiinflammatory therapy; ; 2000; 0 f; Tese (Doutorado em Faculty Of Science) - University of London,; Orientador: Mauro Perretti;

Felicity Gavins

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms; ; 2000; 0 f; Tese (Doutorado em Faculty Of Science) - University of London,; Orientador: Mauro Perretti;

Anita Tailor

Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC; ; 1999; 0 f; Tese (Doutorado em Faculty Of Science) - University of London,; Orientador: Mauro Perretti;

Maureen N Ajuebor

Investigation of the functional role played by the chemokine monocyte chemoattractant protein-1 in interleukin-1-induced murine peritonitis; ; 1998; 0 f; Tese (Doutorado em Faculty Of Science) - University of London,; Orientador: Mauro Perretti;

Lina H K Lim

Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1; ; 1998; 0 f; Tese (Doutorado em Faculty Of Science) - University of London,; Orientador: Mauro Perretti;

JG Harris

Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC); ; 1996; 0 f; Tese (Doutorado em Faculty Of Science) - University of London,; Orientador: Mauro Perretti;

Produções bibliográficas

  • YONA, S ; BUCKINGHAM, Jc ; PERRETTI, Mauro ; FLOWER, Rj . Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages. British Journal of Pharmacology , Inglaterra, v. 142, n.5, p. 890-8, 2004.

  • PERRETTI, Mauro ; SOLITO, e . Annexin 1 and neutrophil apoptosis.. Biochemical Society Transactions , v. 32, n.Pt-3, p. 507-510, 2004.

  • PERRETTI, Mauro ; FLOWER, Rj . Annexin 1 and the biology of the neutrophil.. Journal of Leukocyte Biology , v. 76, n.1, p. 25-29, 2004.

  • PERRETTI, Mauro ; ONGINI, e ; NUNEZ, M Del Carmen ; ROMAGNOLI, R ; BARALDI, Pg . Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide. . Journal of Medicinal Chemistry , v. 47, n.3, p. 711-719, 2004.

  • PERRETTI, Mauro . MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. . Journal of Leukocyte Biology , 2004.

  • PERRETTI, Mauro . Inflammatory resolution: new opportunities for drug discovery. . Nature Reviews Drug Discovery, v. 3, p. 401-416, 2004.

  • PERRETTI, Mauro . The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1. . Journal of Pharmacology and Experimental Therapeutics , v. 310, p. 1133-1141, 2004.

  • PERRETTI, Mauro . Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides. . Pain (Amsterdam) , v. 109, p. 52-63, 2004.

  • PERRETTI, Mauro . Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. . Journal of Immunological Methods , v. 172, p. 4493-4502, 2004.

  • PERRETTI, Mauro . Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. . Arthritis and Rheumatism , v. 50, p. 976-984, 2004.

  • PERRETTI, Mauro . Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide. . Journal of Medicinal Chemistry , v. 47, p. 711-719, 2004.

  • PERRETTI, Mauro . The annexin 1 receptor(s): is the plot unravelling? . Trends in Pharmacological Sciences , v. 24, p. 574-579, 2003.

  • PERRETTI, Mauro . A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation. . The American Journal of Pathology , v. 163, p. 1505-1515, 2003.

  • PERRETTI, Mauro . Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. . Journal of Immunology (Baltimore) , v. 171, p. 3245-3252, 2003.

  • PERRETTI, Mauro . Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids. . Digestive And Liver Disease, v. 35, p. 41-48, 2003.

  • PERRETTI, Mauro . A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. . The FASEB Journal , v. 17, p. 1544-1546, 2003.

  • PERRETTI, Mauro . Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides. . Journal of Pharmacology and Experimental Therapeutics , v. 306, p. 631-637, 2003.

  • PERRETTI, Mauro . Annexin 1: an endogenous anti-inflammatory protein. . News In Phisiological Sciences, v. 18, p. 60-64, 2003.

  • PERRETTI, Mauro . Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. . Journal of Immunology (Baltimore) , v. 170, p. 3323-3330, 2003.

  • PERRETTI, Mauro . Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. . Blood Cells, Molecules & Diseases , v. 101, p. 4140-4147, 2003.

  • PERRETTI, Mauro . Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. . Biochemical Pharmacology , v. 65, p. 153-159, 2003.

  • PERRETTI, Mauro . Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. . The FASEB Journal , v. 17, p. 253-255, 2003.

  • PERRETTI, Mauro . The annexin-1 knockout mouse: what it tells us about the inflammatory response. . Canadian Journal of Physiology and Pharmacology , v. 53, p. 541-553, 2002.

  • PERRETTI, Mauro . Annexin 1 localisation in tissue eosinophils as detected by electron microscopy. . Mediators of Inflammation , v. 11, p. 287-292, 2002.

  • PERRETTI, Mauro . Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model. . Journal of Immunology (Baltimore) , v. 169, p. 2085-2092, 2002.

  • PERRETTI, Mauro . Regulation of leukocyte-endothelial interactions by glucocorticoids. . Ann. N. Y. Academy Scien., v. 966, p. 108-118, 2002.

  • PERRETTI, Mauro . A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones. . The FASEB Journal , v. 16, p. 730-732, 2002.

  • PERRETTI, Mauro . Chemokines as novel therapeutic targets in inflammatory diseases. . Biochemical Pharmacology , v. 63, p. 1191-1196, 2002.

  • PERRETTI, Mauro . Characterization of CXC and CC chemokine expression in a murine model of chronic granuloma. . Inflammation Research , v. 51, p. 110-111, 2002.

  • PERRETTI, Mauro . Cell localization of the anti-inflammatory protein annexin 1 during experimental inflammatory response. . Italian Journal of Anatomy and Embryology , v. 106, p. 69-77, 2001.

  • PERRETTI, Mauro . Analysis of the temporal expression of chemokines and chemokine receptors during experimental granulomatous inflammation: role and expression of MIP-1alpha and MCP-1. . Brazilian Journal Of Pharmacology, v. 134, p. 1166-1179, 2001.

  • PERRETTI, Mauro . Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment. . European Journal of Pharmacology , v. 429, p. 263-278, 2001.

  • PERRETTI, Mauro . Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action. . The FASEB Journal , v. 15, p. 2247-2256, 2001.

  • PERRETTI, Mauro . Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity. . European Journal of Pharmacology , v. 426, p. 123-130, 2001.

  • PERRETTI, Mauro . Morphological alteration of peritoneal mast cells and macrophages in the mouse peritoneal cavity during the early phases of an allergic inflammatory reaction. . Cell Biology International , v. 25, p. 795-803, 2001.

  • PERRETTI, Mauro . Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. . The American Journal of Pathology , v. 158, p. 1969-1973, 2001.

  • PERRETTI, Mauro . Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. . Brazilian Journal Of Pharmacology, v. 133, p. 217-228, 2001.

  • PERRETTI, Mauro . Natural and synthetic agonists of the melanocortin receptor type 3 possess anti-inflammatory properties. . Journal of Leukocyte Biology , v. 69, p. 98-104, 2001.

  • PERRETTI, Mauro . Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1. . Clinical and Experimental Immunology , v. 123, p. 62-67, 2001.

  • PERRETTI, Mauro . Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression. . The American Journal of Pathology , v. 158, p. 603-615, 2001.

  • PERRETTI, Mauro . 21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties. . Brazilian Journal Of Pharmacology, v. 131, p. 1345-1354, 2000.

  • PERRETTI, Mauro . Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment. . The FASEB Journal , v. 14, p. 1867-1869, 2000.

  • PERRETTI, Mauro . An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: modulation by inflammation and dexamethasone. . Laboratory Investigation , v. 80, p. 1429-1438, 2000.

  • PERRETTI, Mauro . Association between kinin B(1) receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules. . Journal of Experimental Medicine , v. 192, p. 367-380, 2000.

  • PERRETTI, Mauro . The microcirculation and inflammation: site of action for glucocorticoids. . Microcirculation (New York) , v. 7, p. 147-161, 2000.

  • PERRETTI, Mauro . Heparin and inflammation: a new use for an old GAG? . Gut (London) , v. 47, p. 14-15, 2000.

  • PERRETTI, Mauro . Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I). . Life Sciences , v. 66, p. 265-270, 2000.

  • PERRETTI, Mauro . Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis. . Cell Biology International , v. 24, p. 163-174, 2000.

  • PERRETTI, Mauro . Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-kappaB but not protein tyrosine kinase: comparison to induction of iNOS. . Mediators of Inflammation , v. 8, p. 77-84, 1999.

  • PERRETTI, Mauro . Differential modulation of annexin I binding sites on monocytes and neutrophils. . Mediators of Inflammation , v. 8, p. 53-62, 1999.

  • PERRETTI, Mauro . Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx. . Inflammation Research , v. 48, p. 140-141, 1999.

  • PERRETTI, Mauro . Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC. . Gut (London) , v. 45, p. 705-712, 1999.

  • PERRETTI, Mauro . Inducible expression of the kinin B1 receptor in the endotoxemic heart: mechanisms of des-Arg9bradykinin-induced coronary vasodilation. . Brazilian Journal Of Pharmacology, v. 128, p. 275-282, 1999.

  • PERRETTI, Mauro . Contrasting roles for RANTES and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in a murine model of allergic peritonitis. . Clinical and Experimental Immunology , v. 117, p. 223-229, 1999.

  • PERRETTI, Mauro . POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. Journal of Immunology (Baltimore) , v. 162, p. 7446-7453, 1999.

  • PERRETTI, Mauro . Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions. . Journal of Leukocyte Biology , v. 65, p. 583-589, 1999.

  • PERRETTI, Mauro . Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1. . Brazilian Journal Of Pharmacology, v. 126, p. 1307-1314, 1999.

  • PERRETTI, Mauro . B1 receptors as a new inflammatory target. Could this B the 1? . Trends in Pharmacological Sciences , v. 20, p. 100-104, 1999.

  • PERRETTI, Mauro . Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation. . Biochemical and Biophysical Research Communications , v. 255, p. 279-282, 1999.

  • PERRETTI, Mauro . Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. . Journal of Immunology (Baltimore) , v. 162, p. 1685-1691, 1999.

  • PERRETTI, Mauro ; OLIANI, Sonia Maria . Localization of the anti-inflammatory protein annexin 1 in several cell types during an on-going inflammatory response. In: P. M. Motta. (Org.). Advances in microanatomy of cells and tissues, biophisical and biochemical correlates. Roma: Italian Journal of Anatomy and Embryology, 2000, v. 7, p. -.

  • PERRETTI, Mauro . Nitro-steroids and galectins, new ways to drug discovery. 2002. (Apresentação de Trabalho/Comunicação).

  • PERRETTI, Mauro . Annexin 1 receptor and neutrophil biology. 2001. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . The annexin 1 receptor. 2001. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Anti-inflammatory agonists: new perspectives for drug therapy. 2001. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Annexin 1 and the neutrophil. 2001. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Annexin 1 peptides. 2000. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Pharmacology of leukocyte migration. 2000. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Bradykinin B1 receptor and other novel targets for anti-inflammatory therapy. 2000. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Pharmacological modulation of leukocyte of leukocyte migration. 2000. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Leukocyte annexin 1 receptor. 2000. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Lipocortin 1 modulates neutrophils recruitment.. 1999. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . The annexin 1 pathway in human leukocytes. 1999. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Anti-inflammatory mediators that regulate leukocyte emigration. 1999. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Annexin 1and the process of cell migration. 1999. (Apresentação de Trabalho/Seminário).

  • PERRETTI, Mauro . Anti-inflammatory mediators. 1999. (Apresentação de Trabalho/Seminário).

Outras produções

PERRETTI, Mauro . Editor of Journal of Pharmacological and Toxicological Methods. 2001.

PERRETTI, Mauro . Editor of Inflammation Research. 2000.

PERRETTI, Mauro . Editor of Microcirculation. 1999.

PERRETTI, Mauro . Editor fo the British Journal of Pharmacology. 1998.

Projetos de pesquisa

  • 2013 - Atual

    Papel do receptor GPR40 na artrite reumatoide, Descrição: Papel do receptor GPR40 na artrite reumatoide. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (1) Doutorado: (2) . , Integrantes: Mauro Perretti - Coordenador / Patricia Regina Soares de Souza - Integrante / Lucy Victoria Norling - Integrante.

Prêmios

2000

Quintiles Prize, British Pharmacological Society.

1998

Cattlin Prize, Joint Research Board of the Special Trustees of St. Bartholomew´s Hospital.

1997

Fellowship of the Arthritis Research Campaign, Arthritis Research Campaign.

Histórico profissional

Endereço profissional

  • The William Harvey Research Institute, Department Of Biochemical Pharmacology. , Charterhouse Square, NA, 16 - Londres, - Inglaterra, Telefone: (44) 0207882606, Fax: (44) 207882607, URL da Homepage:

Experiência profissional

2013 - Atual

William Harvey Research Institute

Vínculo: , Enquadramento Funcional:

1991 - 1993

University of London

Vínculo: pesquisador, Enquadramento Funcional: pesquisador, Carga horária: 0, Regime: Dedicação exclusiva.

Atividades

  • 09/2001

    Ensino, Medicine, Nível: Graduação,Disciplinas ministradas, Immunopharmacology

  • 09/2000

    Direção e administração, St. Bartholomew'S Hospital Medical College, The William Harvey Research Institute.,Cargo ou função, Vice-chefe do Dept of Biochemical Pharmacology.

  • 05/1993 - 04/1998

    Pesquisa e desenvolvimento , St. Bartholomew'S Hospital Medical College, The William Harvey Research Institute.,Linhas de pesquisa

  • 05/1991 - 04/1993

    Pesquisa e desenvolvimento , St. Bartholomew'S Hospital Medical College, The William Harvey Research Institute.,Linhas de pesquisa

Propriedade Intelectual

Patentes (1)

Criando um monitoramento

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continuar

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Criando um monitoramento

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Para criar um monitoramento é preciso estar cadastrado

continuar

15 segundos

para se cadastrar

+ de 900 mil

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