Zohaib Nisar Khan

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Áreas de atuação

Participação em eventos

Produções bibliográficas

• AMADEU DE OLIVEIRA, FLÁVIA ; MACVINISH, LESLEY J. ; AMIN, SIMRAN ; HERATH, DULENI ; JEGGLE, PIA ; MELA, IOANNA ; PIERI, MARIA ; SHARMA, CHETANYA ; JARVIS, GAVIN E. ; LEVY, FLÁVIA M. ; SANTESSO, MARIANA R. ; KHAN, ZOHAIB N. ; LEITE, ALINE L. ; OLIVEIRA, RODRIGO C. ; BUZALAF, MARÍLIA A.R. ; EDWARDSON, J. MICHAEL . The effect of fluoride on the structure, function, and proteome of intestinal epithelia. ENVIRONMENTAL TOXICOLOGY , v. 33, p. 63-71, 2017.

• SANTIAGO, A.C. ; KHAN, Z.N. ; MIGUEL, M.C. ; GIRONDA, C.C. ; SOARES-COSTA, A. ; PELÁ, V.T. ; LEITE, A.L. ; EDWARDSON, J.M. ; BUZALAF, M.A.R. ; HENRIQUE-SILVA, F. . A New Sugarcane Cystatin Strongly Binds to Dental Enamel and Reduces Erosion. Journal of Dental Research , v. 96, p. 1051-1057, 2017.

• KHAN, ZOHAIB NISAR ; LEITE, ALINE DE LIMA ; CHARONE, SENDA ; SABINO, ISABELA TOMAZINI ; MARTINI, TATIANA ; PEREIRA, HELOÍSA APARECIDA BARBOSA DA SILVA ; OLIVEIRA, RODRIGO CARDOSO ; BUZALAF, MARÍLIA AFONSO RABELO . Liver proteome of mice with different genetic susceptibilities to the effects of fluoride. Journal of Applied Oral Science , v. 24, p. 250-257, 2016.

• KHAN, Z.N. ; SABIR, M. ; KAYANI, M.A. ; SAEED, M. . Acetylation of Retinoblastoma Like Protein2 (Rb2/p130) in Tumor Tissues. Asian Pacific Journal of Cancer Prevention , v. 14, p. 2255-2258, 2013.

• KHAN, Z. N. ; SABINO, ISABELA TOMAZINI ; MELO, C. ; MARTINI, TATIANA ; PEREIRA, HELOÍSA APARECIDA BARBOSA DA SILVA ; BUZALAF, M. A. R. . Liver proteome of mice with distinct genetic susceptibilities to fluorosis treated with different concentrations of F in the drinking water. Biological Trace Element Research , 2018.

Projetos de pesquisa

• 2015 - 2017

  Proteomic analysis of the static and compensated magnetic field inclined to in-vitro cell proliferation, Situação: Concluído; Natureza: Pesquisa.

• 2014 - 2015

  Incidence, Dose-response effect of Fluoride on parameters related to insulin resistance in mice strains with different susceptibilities to fluorosis, Situação: Concluído; Natureza: Pesquisa.

• 2014 - 2014

  Effect of supplementation of soft drinks with magnesium lactate on their erosive potential, Situação: Concluído; Natureza: Pesquisa.

• 2014 - Atual

  Proteomic Analysis of Liver in mice with different susceptibilities to Fluorosis, Descrição: Concern over the possible carcinogenic potential of fluoride has been voiced over the past 25 years. It has also been suggested that there may be an association between lifetime exposure to low level fluoride in drinking water and the susceptibility to hip joint fracture in old age. Fluoride in various chemical forms, doses, and exposures has physicochemical and biologic effects on cells and tissues. A narrow therapeutic/toxicity window and biphasic actions further complicate our understanding of fluoride?s effects. Fluorides mediate their actions through MAPK signaling pathways, leading to changes in gene expression, cell stress, and even cell death. The uncertainty associated with increased intake of fluoride is a major area of concern in an aging world population and needs further clarification by detailed examination to reach a more definite conclusion. The wide spread use of F has added to caries decline more over the excessive intake may effect the bone metabolism and enamel development which ultimately leads to skeletal and dental fluorosis.Many sources are there for flouride intake such as drinking water,use of dental products, food, toothpastes and infant formulas [1].Strong evidences are there to prove that increase in prevalence of dental fluorosis is linked to both flouridated and non fluoridated communities [2]. Although the exact mechanism by which flouride affects bio mineralization process are still to be interpreted [3,4].It`s been already proposed that genetic determinants influence the susceptibility to dental fluorosis in humans [5] and mice [6] respectively.In this context of DF two strains of mice have been identified with different responses to the effects of F in the mineralized tissues.The A/J strain is "Susceptible" with the rapid onset of development of DF, while the 129P3/J is "resistant" with minimum development of DF [6] not only this the mentioned to strains also differ towards their susceptibilities to the effect of F in bone [7,8]. Evidences are also there to suggest that drinking water fluoride levels over 2.0mg/L can cause damage to liver and kidney functions in children and that the dental fluorosis was independent of damage to the liver but not the kidney [9]. Further studies on the mechanisms and significance underlying damage to the liver without dental fluorosis in the exposed children are warranted.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Zohaib Nisar khan - Integrante / Marilia Afonso Rabelo Buzalaf - Coordenador.

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