Jesper Ryge

Pós-doutorado

Idiomas

Áreas de atuação

Produções bibliográficas

• TALPALAR, ADOLFO E. ; ENDO, TOSHIAKI ; LÖW, PETER ; BORGIUS, LOTTA ; HÄGGLUND, MARTIN ; DOUGHERTY, KIMBERLY J. ; RYGE, JESPER ; HNASKO, THOMAS S. ; KIEHN, OLE . Identification of Minimal Neuronal Networks Involved in Flexor-Extensor Alternation in the Mammalian Spinal Cord. Neuron (Cambridge, Mass.) , v. 71, p. 1071-1084, 2011.

• BERG, D. A. ; KIRKHAM, M. ; BELJAJEVA, A. ; KNAPP, D. ; HABERMANN, B. ; RYGE, J. ; TANAKA, E. M. ; SIMON, A. . Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain. Development (Cambridge) , v. 137, p. 4127-4134, 2010.

• HOLZ, A. ; KOLLMUS, H. ; RYGE, J. ; NIEDERKOFLER, V. ; DIAS, J. ; ERICSON, J. ; STOECKLI, E. T. ; KIEHN, O. ; ARNOLD, H.-H. . The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance. Development (Cambridge) , v. 137, p. 4249-4260, 2010.

• RYGE, JESPER ; WINTHER, OLE ; WIENECKE, JACOB ; SANDELIN, ALBIN ; WESTERDAHL, ANN-CHARLOTTE ; HULTBORN, HANS ; KIEHN, OLE . Transcriptional regulation of gene expression clusters in motor neurons following spinal cord injury. BMC Genomics , v. 11, p. 365, 2010.

• WIENECKE, J. ; WESTERDAHL, A-C. ; HULTBORN, H. ; KIEHN, O. ; RYGE, J. . Global Gene Expression Analysis of Rodent Motor Neurons Following Spinal Cord Injury Associates Molecular Mechanisms With Development of Postinjury Spasticity. Journal of Neurophysiology , v. 103, p. 761-778, 2010.

• RYGE, JESPER ; WESTERDAHL, ANN-CHARLOTTE ; ALSTR M, PREBEN ; KIEHN, OLE . Gene Expression Profiling of Two Distinct Neuronal Populations in the Rodent Spinal Cord. Plos One , v. 3, p. e3415, 2008.

• NISHIMARU, H. . Mammalian motor neurons corelease glutamate and acetylcholine at central synapses. Proceedings of the National Academy of Sciences of the United States of America , v. 102, p. 5245-5249, 2005.

• ALSTR M, PREBEN ; BEIERHOLM, ULRIK ; NIELSEN, CARSTEN DAHL ; Ryge, Jesper ; KIEHN, OLE . Reliability of neural encoding. Physica. A (Print) , v. 314, p. 61-68, 2002.

• BEIERHOLM, U. ; NIELSEN, C. D. ; RYGE, J. ; ALSTR M, PREBEN ; KIEHN, O. . Characterization of reliability of spike timing in spinal interneurons during oscillating inputs. Journal of Neurophysiology , v. 86, p. 1858-1868, 2001.

Projetos de pesquisa

• 2012 - Atual

  DDPDGENES, Descrição: The goal of this project is to determine whether the expression of developmental genes in defined subpopulations of DA neurons contributes to the specification of currently unrecognized midbrain DA neuron subtypes and whether their missexpression may contribute to the loss of DA neurons in the adulthood and to the pathogenesis of PD. Many developmental genes have been found to be implicated in the maintenance of midbrain DA neurons at postnatal and adult stages, as assessed by the loss of DA neurons in transgenic mice heterozygous for: Nurr1, Pitx3, FoxA2, en1. On the other hand, genes involved in the pathogenesis of genetic forms of PD, such as Lrkk2 and PINK1, do not cause cell death. In this project we hypothesize that a disregulation of the expression of developmental genes may play a previously unrecognized role in PD. We propose to identify subtypes of midbrain DA neurons at a molecular and functional level in: (i) the developing rodent and human ventral midbrain (VM), (ii) human neural and embryonic stem cell preparations differentiated into midbrain DA neurons, and (iii) DA neurons derived from induced pluripotent stem (iPS) cells generated from control and PD patients.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: / Mestrado profissional: (2) / Doutorado: (2) . , Integrantes: Jesper Ryge - Integrante / Sten Linnarsson - Coordenador / Ernest Arenas - Integrante / Roger Barker - Integrante / Rosario Sánchez Pernaute - Integrante / Olivier Hagens - Integrante / Carlos Villaescusa - Integrante / Amit Zeisel - Integrante / Simon Scott - Integrante / Saiful Islam - Integrante.