Aled Edwards

Dr. Aled Edwards is founding and current CEO of the Structural Genomics Consortium (SGC), Professor at the University of Toronto and Visiting Professor at the University of Oxford. Trained as a protein biochemist at McGill University (with Peter Braun) and at Stanford University (with Roger Kornberg), his research interests include structural biology, host-virus interaction, functional proteomics and drug discovery. In 1997, he and Dr. Cheryl Arrowsmith, contemporaneously with others around the world, launched a pilot project in structural genomics. The publication of their pilot project represented the first report of a large-scale effort in structural biology. Since 2000, he and his colleagues have contributed to over 2,000 unique protein structures into the Protein Data Bank and collaborate on many publications. He is a world leader and pioneer on open access and open innovation approaches to drug discovery, and science outreach. During the next years one of his main challenges is to collaborate with Brazil and to bring one SGC hub to the country, and thus help expand the open access science concept and increase local training in structural genomics and drug discovery.

Informações coletadas do Lattes em 04/11/2022

Acadêmico

Formação acadêmica

Doutorado em Biochemistry

1983 - 1988

McGill University
Título: Phosphoryation of myelin-associated glycoprotein
Orientador: Peter Bruan

Pós-doutorado

1988 - 1992

Pós-Doutorado. , Stanford University.

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Francês

Compreende Razoavelmente, Fala Pouco, Lê Razoavelmente, Escreve Pouco.

Áreas de atuação

Grande área: Ciências Biológicas / Área: Bioquímica.

Orientou

Alexandra Ezersky

Towards Fully Automated Structure-based Function Prediction in Structural Genomics: A Case Study; 2007; Dissertação (Mestrado em Medical Research) - University of Toronto,; Coorientador: Aled Edwards;

Patricia Pan

Structure and biochemical functions of SIRT6; 2011; Tese (Doutorado em Medical Research) - Canadian Institutes for Health Research,; Orientador: Aled Edwards;

Limin Chen

Cell-type specific gene expression signature in liver underlies response to interferon therapy in chronic hepatitis C infection; 2010; Tese (Doutorado em Medical Research) - Canadian Institute for Health Research, Canada Graduate Scholarship (CGS) from the Canadian Institute of Health Res; Orientador: Aled Edwards;

Keith Pardee

The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta; ; 2009; Tese (Doutorado em Medical Research) - University of Toronto,; Orientador: Aled Edwards;

Bart Kus

Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro; 2004; Tese (Doutorado em Medical Research) - University of Toronto,; Orientador: Aled Edwards;

Valerie Booth

Structure of a Conserved Domain Common to Transcription Factors TFIIS, Elongin A and CRSP70; 2000; Tese (Doutorado em Medical Research) - University of Toronto,; Orientador: Aled Edwards;

Christopher M

Koth; Elongin from Saccharomyces cerevisiae; ; 2000; Tese (Doutorado em Medical Genetics and Microbiology) - University of Toronto,; Orientador: Aled Edwards;

Jeff Reinking

2009; University of Toronto,; Aled Edwards;

Claudio Gonzalez

2006; University of Toronto,; Aled Edwards;

KAREN L

MAXWELL; 2003; University of Toronto, Canadian Institutes for Health Research; Aled Edwards;

Alexei Savchenko

2003; University of Toronto,; Aled Edwards;

Pascale Macgregor

2001; University of Toronto,; Aled Edwards;

Produções bibliográficas

EDWARDS, A. M. ; DAVIDSON, A. R. . Structural and Functional Studies of gpX of Escherichia coli Phage P2 Reveal a Widespread Role for LysM Domains in the Baseplates of Contractile-Tailed Phages. Journal of Bacteriology (Print) , v. 195, p. 5461-5468, 2013.
MASUM, HASSAN ; RAO, AARTHI ; GOOD, BENJAMIN M. ; TODD, MATTHEW H. ; EDWARDS, ALED M. ; CHAN, LESLIE ; BUNIN, BARRY A. ; SU, ANDREW I. ; THOMAS, ZAKIR ; BOURNE, PHILIP E. . Ten Simple Rules for Cultivating Open Science and Collaborative R&D. PLOS Computational Biology (Online) , v. 9, p. e1003244, 2013.
TAM, WILLIAM ; PELL, LISA G. ; BONA, DIANE ; TSAI, ALEX ; DAI, XIAO XIAN ; EDWARDS, ALED M. ; HENDRIX, ROGER W. ; MAXWELL, KAREN L. ; DAVIDSON, ALAN R. . Tail Tip Proteins Related to Bacteriophage λ gpL Coordinate an Iron-Sulfur Cluster. Journal of Molecular Biology , v. 425, p. 2450-2462, 2013.
PELL, LISA G. ; CUMBY, NICHOLE ; CLARK, TERESA E. ; TUITE, ASHLEIGH ; BATTAILE, KEVIN P. ; EDWARDS, ALED M. ; CHIRGADZE, NICKOLAY Y. ; DAVIDSON, ALAN R. ; MAXWELL, KAREN L. . A Conserved Spiral Structure for Highly Diverged Phage Tail Assembly Chaperones. Journal of Molecular Biology , v. 425, p. 2436-2449, 2013.
SHINTRE, C. A. ; PIKE, A. C. W. ; LI, Q. ; KIM, J.-I. ; BARR, A. J. ; GOUBIN, S. ; SHRESTHA, L. ; YANG, J. ; BERRIDGE, G. ; ROSS, J. ; STANSFELD, P. J. ; SANSOM, M. S. P. ; EDWARDS, A. M. ; BOUNTRA, C. ; MARSDEN, B. D. ; VON DELFT, F. ; BULLOCK, A. N. ; GILEADI, O. ; BURGESS-BROWN, N. A. ; CARPENTER, E. P. . Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proceedings of the National Academy of Sciences of the United States of America , v. 110, p. 9710-9715, 2013.
AEBERSOLD, RUEDI ; BADER, GARY D. ; EDWARDS, ALED M. ; VAN EYK, JENNIFER E. ; KUSSMANN, MARTIN ; QIN, JUN ; OMENN, GILBERT S. . The Biology/Disease-driven Human Proteome Project (B/D-HPP): Enabling Protein Research for the Life Sciences Community. Journal of Proteome Research (Print) , v. 12, p. 23-27, 2013.
STRUSHKEVICH, NATALLIA ; GILEP, ANDREI A. ; SHEN, LIMIN ; ARROWSMITH, CHERYL H. ; EDWARDS, ALED M. ; USANOV, SERGEY A. ; PARK, HEE-WON . Structural Insights into Aldosterone Synthase Substrate Specificity and Targeted Inhibition. Molecular Endocrinology (Baltimore, Md.) , v. 27, p. 315-324, 2013.
QUIGLEY, A. ; DONG, Y. Y. ; PIKE, A. C. W. ; DONG, L. ; SHRESTHA, L. ; BERRIDGE, G. ; STANSFELD, P. J. ; SANSOM, M. S. P. ; EDWARDS, A. M. ; BOUNTRA, C. ; VON DELFT, F. ; BULLOCK, A. N. ; BURGESS-BROWN, N. A. ; CARPENTER, E. P. . The Structural Basis of ZMPSTE24-Dependent Laminopathies. Science (New York, N.Y.) , v. 339, p. 1604-1607, 2013.
KNAPP, STEFAN ; ARRUDA, PAULO ; BLAGG, JULIAN ; BURLEY, STEPHEN ; DREWRY, DAVID H ; EDWARDS, ALED ; FABBRO, DORIANO ; GILLESPIE, PAUL ; GRAY, NATHANAEL S ; KUSTER, BERNHARD ; LACKEY, KAREN E ; MAZZAFERA, PAULO ; TOMKINSON, NICHOLAS C O ; WILLSON, TIMOTHY M ; WORKMAN, PAUL ; ZUERCHER, WILLIAM J . A public-private partnership to unlock the untargeted kinome. Nature Chemical Biology , v. 9, p. 3-6, 2012.
POREBSKI, PRZEMYSLAW J. ; KLIMECKA, MARIA ; CHRUSZCZ, MAKSYMILIAN ; NICHOLLS, ROBERT A. ; MURZYN, KRZYSZTOF ; CUFF, MARIANNE E. ; XU, XIAOHUI ; CYMBOROWSKI, MARCIN ; MURSHUDOV, GARIB N. ; SAVCHENKO, ALEXEI ; EDWARDS, ALED ; MINOR, WLADEK . Structural characterization of Helicobacter-pylori dethiobiotin synthetase reveals differences between family members. The FEBS Journal (Print) , v. 279, p. 1093-1105, 2012.
BEAULIEU, CHANDREE L ; SAMUELS, MARK E ; EKINS, SEAN ; MCMASTER, CHRISTOPHER R ; EDWARDS, ALED M ; KRAINER, ADRIAN R ; HICKS, GEOFFREY G ; FREY, BRENDAN J ; BOYCOTT, KYM M ; MACKENZIE, ALEX E . A generalizable pre-clinical research approach for orphan disease therapy. Orphanet Journal of Rare Diseases , v. 7, p. 39, 2012.
CUMBY, N. ; EDWARDS, A. M. ; DAVIDSON, A. R. ; MAXWELL, K. L. . The Bacteriophage HK97 gp15 Moron Element Encodes a Novel Superinfection Exclusion Protein. Journal of Bacteriology (Print) , v. 194, p. 5012-5019, 2012.
POPOVIC, A. ; WU, B. ; ARROWSMITH, C. H. ; EDWARDS, A. M. ; DAVIDSON, A. R. ; MAXWELL, K. L. . Structural and Biochemical Characterization of Phage FI Protein (gpFI) Reveals a Novel Mechanism of DNA Packaging Chaperone Activity. The Journal of Biological Chemistry (Print) , v. 287, p. 32085-32095, 2012.
NORMAN, T. C. ; BOUNTRA, C. ; EDWARDS, A. M. ; YAMAMOTO, K. R. ; FRIEND, S. H. . Leveraging Crowdsourcing to Facilitate the Discovery of New Medicines. Science Translational Medicine , v. 3, p. 88mr1-88mr1, 2011.
FILIPPOVA, EKATERINA V. ; CHRUSZCZ, MAKSYMILIAN ; CYMBOROWSKI, MARCIN ; GU, JUN ; SAVCHENKO, ALEXEI ; EDWARDS, ALED ; MINOR, WLADEK . Crystal structure of a putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) reveals an unusual dimer among TetR family proteins. Journal of Structural and Functional Genomics , v. 12, p. 149-157, 2011.
VEDADI, MASOUD BARSYTE-LOVEJOY, DALIA LIU, FENG RIVAL-GERVIER, SYLVIE ALLALI-HASSANI, ABDELLAH LABRIE, VIVIANE WIGLE, TIM J DIMAGGIO, PETER A WASNEY, GREGORY A SIARHEYEVA, ALENA DONG, AIPING TEMPEL, WOLFRAM WANG, SUN-CHONG CHEN, XIN CHAU, IRENE MANGANO, THOMAS J HUANG, XI-PING SIMPSON, CATHERINE D PATTENDEN, SAMANTHA G NORRIS, JACQUELINE L KIREEV, DMITRI B TRIPATHY, ASHUTOSH EDWARDS, ALED ROTH, BRYAN L JANZEN, WILLIAM P , et al. GARCIA, BENJAMIN A PETRONIS, ARTURAS ELLIS, JAMES BROWN, PETER J FRYE, STEPHEN V ARROWSMITH, CHERYL H JIN, JIAN ; A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature Chemical Biology , v. 7, p. 566-574, 2011.
COLWILL, KAREN PERSSON, HELENA JARVIK, NICHOLAS E WYRZUCKI, ARKADIUSZ WOJCIK, JOHN KOIDE, AKIKO KOSSIAKOFF, ANTHONY A KOIDE, SHOHEI SIDHU, SACHDEV DYSON, MICHAEL R PERSHAD, KRITIKA PAVLOVIC, JOHN D KARATT-VELLATT, ANEESH SCHOFIELD, DARREN J KAY, BRIAN K MCCAFFERTY, JOHN MERSMANN, MICHAEL MEIER, DORIS MERSMANN, JANA HELMSING, SASKIA HUST, MICHAEL DÜBEL, STEFAN BERKOWICZ, SUSIE FREEMANTLE, ALEXIA SPIEGEL, MICHAEL , et al. SAWYER, ALAN LAYTON, DANIEL NICE, EDOUARD DAI, ANNA ROCKS, OLIVER WILLITON, KELLY FELLOUSE, FREDERIC A HERSI, KADIJA PAWSON, TONY NILSSON, PETER SUNDBERG, M RTEN SJÖBERG, RONALD SIVERTSSON, SA SCHWENK, JOCHEN M TAKANEN, JENNY OTTOSSON HOBER, SOPHIA UHLÉN, MATHIAS DAHLGREN, LARS-GÖRAN FLORES, ALEX JOHANSSON, IDA WEIGELT, JOHAN CROMBET, LISSETTE LOPPNAU, PETER KOZIERADZKI, IVONA COSSAR, DOUG ARROWSMITH, CHERYL H EDWARDS, ALED M GRÄSLUND, SUSANNE ; A roadmap to generate renewable protein binders to the human proteome. Nature Methods , v. 8, p. 551-558, 2011.
NORMAN, T. ; EDWARDS, A. ; BOUNTRA, C. ; FRIEND, S. . The Precompetitive Space: Time to Move the Yardsticks. Science Translational Medicine , v. 3, p. 76cm10-76cm10, 2011.
OSIPIUK, JERZY ; XU, XIAOHUI ; CUI, HONG ; SAVCHENKO, ALEXEI ; EDWARDS, ALED ; JOACHIMIAK, ANDRZEJ . Crystal structure of secretory protein Hcp3 from Pseudomonas aeruginosa. Journal of Structural and Functional Genomics , v. 12, p. 21-26, 2011.
KLIMECKA, MARIA M. ; CHRUSZCZ, MAKSYMILIAN ; FONT, JOSE ; SKARINA, TATIANA ; SHUMILIN, IGOR ; ONOPRYIENKO, OLENA ; POREBSKI, PRZEMYSLAW J. ; CYMBOROWSKI, MARCIN ; ZIMMERMAN, MATTHEW D. ; HASSEMAN, JEREMY ; GLOMSKI, IAN J. ; LEBIODA, LUKASZ ; SAVCHENKO, ALEXEI ; EDWARDS, ALED ; MINOR, WLADEK . Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis. Journal of Molecular Biology , v. 410, p. 411-423, 2011.
PAN, P. W. ; FELDMAN, J. L. ; DEVRIES, M. K. ; DONG, A. ; EDWARDS, A. M. ; DENU, J. M. . Structure and Biochemical Functions of SIRT6. The Journal of Biological Chemistry (Print) , v. 286, p. 14575-14587, 2011.
EDWARDS, ALED M. ; ISSERLIN, RUTH ; BADER, GARY D. ; FRYE, STEPHEN V. ; WILLSON, TIMOTHY M. ; YU, FRANK H. . Too many roads not taken. Nature (London) , v. 470, p. 163-165, 2011.
GROOTENDORST, P. ; HOLLIS, A. ; LEVINE, D. K. ; POGGE, T. ; EDWARDS, A. M. . New approaches to rewarding pharmaceutical innovation. CMAJ. Canadian Medical Association Journal , v. 183, p. 681-685, 2011.
BABU, MOHAN ; BELOGLAZOVA, NATALIA ; FLICK, ROBERT ; GRAHAM, CHRIS ; SKARINA, TATIANA ; NOCEK, BOGUSLAW ; GAGARINOVA, ALLA ; POGOUTSE, OXANA ; BROWN, GREG ; BINKOWSKI, ANDREW ; PHANSE, SADHNA ; JOACHIMIAK, ANDRZEJ ; KOONIN, EUGENE V. ; SAVCHENKO, ALEXEI ; EMILI, ANDREW ; GREENBLATT, JACK ; EDWARDS, ALED M. ; YAKUNIN, ALEXANDER F. . A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Molecular Microbiology (Print) , v. 79, p. 484-502, 2011.
PELL, LISA G. ; GASMI-SEABROOK, GENEVIEVE M.C. ; MORAIS, MARC ; NEUDECKER, PHILIPP ; KANELIS, VOULA ; BONA, DIANE ; DONALDSON, LOGAN W. ; EDWARDS, ALED M. ; HOWELL, P. LYNNE ; DAVIDSON, ALAN R. ; MAXWELL, KAREN L. . The Solution Structure of the C-Terminal Ig-like Domain of the Bacteriophage λ Tail Tube Protein. Journal of Molecular Biology , v. 403, p. 468-479, 2010.
MA, X.-Z. ; BARTCZAK, A. ; ZHANG, J. ; KHATTAR, R. ; CHEN, L. ; LIU, M. F. ; EDWARDS, A. ; LEVY, G. ; MCGILVRAY, I. D. . Proteasome Inhibition In Vivo Promotes Survival in a Lethal Murine Model of Severe Acute Respiratory Syndrome. Journal of Virology (Print) , v. 84, p. 12419-12428, 2010.
LUO, HAI-BIN ; ZHENG, HEPING ; ZIMMERMAN, MATTHEW D. ; CHRUSZCZ, MAKSYMILIAN ; SKARINA, TATIANA ; EGOROVA, OLGA ; SAVCHENKO, ALEXEI ; EDWARDS, ALED M. ; MINOR, WLADEK . Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum. Journal of Structural Biology (Print) , v. 169, p. 304-311, 2010.
SENISTERRA, G. A. ; GHANEI, H. ; KHUTORESKAYA, G. ; DOBROVETSKY, E. ; EDWARDS, A. M. ; PRIVE, G. G. ; Vedadi, M. . Assessing the Stability of Membrane Proteins to Detect Ligand Binding Using Differential Static Light Scattering. Journal of Biomolecular Screening , v. 15, p. 314-320, 2010.
CHEN, LIMIN ; BOROZAN, IVAN ; SUN, JING ; GUINDI, MAHA ; FISCHER, SANDRA ; FELD, JORDAN ; ANAND, NITASHA ; HEATHCOTE, JENNY ; EDWARDS, ALED M. ; MCGILVRAY, IAN D. . Cell-Type Specific Gene Expression Signature in Liver Underlies Response to Interferon Therapy in Chronic Hepatitis C Infection. Gastroenterology (New York, N.Y. 1943) , v. 138, p. 1123-1133.e3, 2010.
CHEN, L. ; SUN, J. ; MENG, L. ; HEATHCOTE, J. ; EDWARDS, A. M. ; MCGILVRAY, I. D. . ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment. Journal of General Virology (Print) , v. 91, p. 382-388, 2010.
HORNER, M. A. ; PARDEE, K. ; LIU, S. ; KING-JONES, K. ; LAJOIE, G. ; EDWARDS, A. ; KRAUSE, H. M. ; THUMMEL, C. S. . The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis. Genes & Development , v. 23, p. 2711-2716, 2009.
WANG, SHUREN ; KIRILLOVA, OLGA ; CHRUSZCZ, MAKSYMILIAN ; GRONT, DOMINIK ; ZIMMERMAN, MATTHEW D. ; CYMBOROWSKI, MARCIN T. ; SHUMILIN, IGOR A. ; SKARINA, TATIANA ; GORODICHTCHENSKAIA, ELENA ; SAVCHENKO, ALEXEI ; EDWARDS, ALED M. ; MINOR, WLADEK . The crystal structure of the AF2331 protein from DSM 4304 forms an unusual interdigitated dimer with a new type of α + β fold. Protein Science (Print) , v. 18, p. 2410-2419, 2009.
ALLALI'HASSANI, ABDELLAH ; WASNEY, GREGORY A. ; CHAU, IRENE ; HONG, BUM SOO ; SENISTERRA, GUILLERMO ; LOPPNAU, PETER ; SHI, ZHEN ; MOULT, JOHN ; EDWARDS, ALED M. ; ARROWSMITH, CHERYL H. ; PARK, HEE WON ; SCHAPIRA, MATTHIEU ; VEDADI, MASOUD . A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. Biochemical Journal (London. 1984) , v. 424, p. 15-26, 2009.
EDWARDS, ALED M ; BOUNTRA, CHAS ; KERR, DAVID J ; WILLSON, TIMOTHY M . Open access chemical and clinical probes to support drug discovery. Nature Chemical Biology , v. 5, p. 436-440, 2009.
WERNIMONT, AMY ; EDWARDS, ALED . In Situ Proteolysis to Generate Crystals for Structure Determination: An Update. Plos One , v. 4, p. e5094, 2009.
EDWARDS, ALED . Large-Scale Structural Biology of the Human Proteome. Annual Review of Biochemistry (Print) , v. 78, p. 541-568, 2009.
PARDEE, KEITH I. ; XU, XIAOHUI ; REINKING, JEFF ; SCHUETZ, ANJA ; DONG, AIPING ; LIU, SUYA ; ZHANG, RONGGUANG ; TIEFENBACH, JENS ; LAJOIE, GILLES ; PLOTNIKOV, ALEXANDER N. ; BOTCHKAREV, ALEXEY ; KRAUSE, HENRY M. ; EDWARDS, ALED . The Structural Basis of Gas-Responsive Transcription by the Human Nuclear Hormone Receptor REV-ERBβ. PLoS Biology (Cessou em 2006. Cont. ISSN 1545-7885 PLoS Biology (Online)) , v. 7, p. e43, 2009.
BROWN, G. ; SINGER, A. ; LUNIN, V. V. ; PROUDFOOT, M. ; SKARINA, T. ; FLICK, R. ; KOCHINYAN, S. ; SANISHVILI, R. ; JOACHIMIAK, A. ; EDWARDS, A. M. ; SAVCHENKO, A. ; YAKUNIN, A. F. . Structural and Biochemical Characterization of the Type II Fructose-1,6-bisphosphatase GlpX from Escherichia coli. The Journal of Biological Chemistry (Print) , v. 284, p. 3784-3792, 2009.
NOCEK, B. ; KOCHINYAN, S. ; PROUDFOOT, M. ; BROWN, G. ; EVDOKIMOVA, E. ; OSIPIUK, J. ; EDWARDS, A. M. ; SAVCHENKO, A. ; JOACHIMIAK, A. ; YAKUNIN, A. F. . Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria. Proceedings of the National Academy of Sciences of the United States of America , v. 105, p. 17730-17735, 2008.
EDWARDS, ALED . Open-source science to enable drug discovery. Drug Discovery Today , v. 13, p. 731-733, 2008.
BOROZAN, IVAN ; CHEN, LIMIN ; PAEPER, BRYAN ; HEATHCOTE, JENNY E ; EDWARDS, ALED M ; KATZE, MICHAEL ; ZHANG, ZHAOLEI ; MCGILVRAY, IAN D . MAID : An effect size based model for microarray data integration across laboratories and platforms. BMC Bioinformatics , v. 9, p. 305, 2008.
BELOGLAZOVA, N. ; BROWN, G. ; ZIMMERMAN, M. D. ; PROUDFOOT, M. ; MAKAROVA, K. S. ; KUDRITSKA, M. ; KOCHINYAN, S. ; WANG, S. ; CHRUSZCZ, M. ; MINOR, W. ; KOONIN, E. V. ; EDWARDS, A. M. ; SAVCHENKO, A. ; YAKUNIN, A. F. . A Novel Family of Sequence-specific Endoribonucleases Associated with the Clustered Regularly Interspaced Short Palindromic Repeats. The Journal of Biological Chemistry (Print) , v. 283, p. 20361-20371, 2008.
CHEN, LIMIN ; BOROZAN, IVAN ; MILKIEWICZ, PIOTR ; SUN, JING ; MENG, XIANGBIN ; COLTESCU, CATALINA ; EDWARDS, ALED M. ; OSTROWSKI, MARIO A. ; GUINDI, MAHA ; HEATHCOTE, ELIZABETH J. ; MCGILVRAY, IAN D. . Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver International (Print) , v. 28, p. 997-1010, 2008.
EDWARDS, ALED . Bermuda Principles meet structural biology. Nature Structural and Molecular Biology , v. 15, p. 116-116, 2008.
SELZNER, NAZIA ; CHEN, LIMIN ; BOROZAN, IVAN ; EDWARDS, ALED ; HEATHCOTE, E. JENNY ; MCGILVRAY, IAN . Hepatic gene expression and prediction of therapy response in chronic hepatitis C patients. Journal of Hepatology , v. 48, p. 708-713, 2008.
GRÄSLUND, SUSANNE NORDLUND, PÄR WEIGELT, JOHAN BRAY, JAMES GILEADI, OPHER KNAPP, STEFAN OPPERMANN, UDO ARROWSMITH, CHERYL HUI, RAYMOND MING, JINRONG DHE-PAGANON, SIRANO PARK, HEE-WON SAVCHENKO, ALEXEI YEE, ADELINDA EDWARDS, ALED VINCENTELLI, RENAUD CAMBILLAU, CHRISTIAN KIM, ROSALIND KIM, SUNG-HOU RAO, ZIHE SHI, YUNYU TERWILLIGER, THOMAS C KIM, CHANG-YUB HUNG, LI-WEI WALDO, GEOFFREY S , et al. PELEG, YOAV ALBECK, SHIRA UNGER, TAMAR DYM, ORLY PRILUSKY, JAIME SUSSMAN, JOEL L STEVENS, RAY C LESLEY, SCOTT A WILSON, IAN A JOACHIMIAK, ANDRZEJ COLLART, FRANK DEMENTIEVA, IRINA DONNELLY, MARK I ESCHENFELDT, WILLIAM H KIM, YOUNGCHANG STOLS, LUCY WU, RUYING ZHOU, MIN BURLEY, STEPHEN K EMTAGE, J SPENCER SAUDER, J MICHAEL THOMPSON, DEVON BAIN, KEVIN LUZ, JOHN GHEYI, TARUN ZHANG, FRED ATWELL, SHANE ALMO, STEVEN C BONANNO, JEFFREY B FISER, ANDRAS SWAMINATHAN, SIVASUBRAMANIAN STUDIER, F WILLIAM CHANCE, MARK R SALI, ANDREJ ACTON, THOMAS B XIAO, RONG ZHAO, LI MA, LI CHUNG HUNT, JOHN F TONG, LIANG CUNNINGHAM, KELLIE INOUYE, MASAYORI ANDERSON, STEPHEN JANJUA, HELEEMA SHASTRY, RITU HO, CHI KENT WANG, DONGYAN WANG, HUANG JIANG, MEI MONTELIONE, GAETANO T STUART, DAVID I OWENS, RAYMOND J DAENKE, SUSAN SCHÜTZ, ANJA HEINEMANN, UDO YOKOYAMA, SHIGEYUKI BÜSSOW, KONRAD GUNSALUS, KRISTIN C ; Protein production and purification. Nature Methods , v. 5, p. 135-146, 2008.
PROUDFOOT, MICHAEL ; SANDERS, STEPHEN A. ; SINGER, ALEX ; ZHANG, RONGGUANG ; BROWN, GREG ; BINKOWSKI, ANDREW ; XU, LINDA ; LUKIN, JONATHAN A. ; MURZIN, ALEXEY G. ; JOACHIMIAK, ANDRZEJ ; ARROWSMITH, CHERYL H. ; EDWARDS, ALED M. ; SAVCHENKO, ALEXEI V. ; YAKUNIN, ALEXANDER F. . Biochemical and Structural Characterization of a Novel Family of Cystathionine β-Synthase Domain Proteins Fused to a Zn Ribbon-Like Domain. Journal of Molecular Biology , v. 375, p. 301-315, 2008.
EDWARDS, ALED M. ; EDWARDS, ELIZABETH A. . A Future for the Protein Structure Initiative. Structure (London) , v. 15, p. 1525-1526, 2007.
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Outras produções

Edwards, AM . 1DegreeBio. 2010.

Edwards, AM . Center for Structural Genomics of Infectious Disease. 2007.

Edwards, AM . Alberta Heritage Foundation for Medical Research. 2007.

Edwards, AM . North American Conditional Mouse Knock-out Consortium (NorCOMM). 2007.

Edwards, AM . NIH Protein Structure Initiative. 2006.

Edwards, AM . NIH Midwest Center for Structural Genomics. 2000.

Histórico profissional

Endereço profissional

University of Toronto. , 101 College Street, MaRS South Tower, Suite 706 M5G 1L7, N/A, 3 - Toronto, - Canadá, Telefone: (416) 9463795

Experiência profissional

2007 - Atual

University of Oxford

Vínculo: Visitor Professor, Enquadramento Funcional: Visiting Professor of Chemical Biology

1997 - 2003

University of Toronto

Vínculo: Formal labor contract, Enquadramento Funcional: Associate Professor

2003 - Atual

Structural Genomics Consortium

Vínculo: Formal labor contract, Enquadramento Funcional: Chief Executive

1999 - 2001

Affinium Pharmaceuticals Inc

Vínculo: Formal labor contract, Enquadramento Funcional: Chief Scientific Officer

1998 - 1999

Chalon Biotech, Inc

Vínculo: Formal labor contract, Enquadramento Funcional: Chief Executive Officer

1992 - 1997

Mcmaster University, MacMaster

Vínculo: Formal labor contract, Enquadramento Funcional: Assistant Professor, Department of