Mohamed Abdelsalam

I have obtained my PhD in Pharmaceutical Sciences from the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo/in a Joint Collaboration with Mayo Clinic School of Medicine, Department of Internal Medicine, MN, United States. My PhD thesis was entitled: Synthesis, antiurolithic activity and biotransformation studies of galloylquinic acids from Copaifera species by filamentous fungi. I have got my Master's (2012) and Bachelor Degrees (2008) in Pharmaceutical Sciences from the Faculty of Pharmacy, University of Alexandria, Egypt. My Master's thesis was entitled: Cytotoxicity, antiviral and tissue culture-based biotransformation study of Berberis vulgaris (L.). I am currently working as a Lecturer of Pharmacognosy at Faculty of Pharmacy, Delta University for Science and Technology, Egypt. I worked as Teaching Assistant at the Department of Pharmaceutical Organic Chemistry (2008-2010). Research Assistant at Cell Culture Unit, Medical Research Institute, University of Alexandria University (2010-2012), during which I was a part of the team of the research project entitled: Efficient anti-HCV vaccine with protein-transduced dendritic cells, Project No. 1557, STDF, Egypt. My overarching research interests revolve around the discovery of new biological molecules as potential drug leads/candidates based on natural products (microbial and medicinal plants secondary metabolites). I perform biological and pharmacological screenings of bioactive isolated and/or semi-synthesized compounds. I use a combination of Pharmaceutical Chemistry and Modern Chemical biology techniques to answer the how, who, where and how fast questions of natural organic molecules as potential entities in drug discovery. More specifically, I am interested in answering biological questions by directly probing living systems at the chemical level as well as examining the direct and intimate relationship between the activity of semi-synthesized plant secondary metabolites, filamentous fungi-transformed molecules and how that signature may translate between generating library of new drug candidates and their structure-activity relationship (SAR). Moreover, the use of cell bioreactors at the meeting point between engineered and biological chemical synthesis. The biological assays I am using involve in vitro and ex vivo cell culture models, molecular biology, cytotoxicity as well as in vivo Drosophila models. My PhD research work included three parts: total synthesis of a bioactive polyphenolic compound; antiurolithic assays based on identifying Calcium oxalate monohydrate-binding proteins of renal cells and their inhibition, Drosophila ex vivo and in vivo crystallization models, ROS scavenging activity; biotransformation of polyphenolics by filamentous fungi. My Master research involved: antiviral, antitumor and biotransformations studies using plant cell culture. I picked up an International Prize of BIOVISION Next/TWAS/Université de Lyon/Pulsalys SATT Lyon St-Etienne, 2015, Lyon, France, in recognition of the most innovative Ph.D. project and its contribution towards life sciences.

Informações coletadas do Lattes em 04/11/2022

Acadêmico

Formação acadêmica

Doutorado em Nephrology and Hypertension - Department of Internal Medicine

2017 - 2018

Mayo Clinic Minnesota
Título: Biological study of the inhibitory effects of some natural and synthetic molecules on calcium oxalate monohydrate adherence to renal cells and crystallization (in vitro and in vivo models using Drosophila melanogaster)
Orientador: Prof. Jairo Kenupp Bastos
com Coorientador: Prof. John Charles Lieske. Bolsista do(a): National Institute of Heath, NIH, Estados Unidos.

Doutorado em Programa de Pós-Graduação em Ciências Farmacêuticas

2015 - 2018

Universidade de São Paulo
Título: Synthesis, antiurolithic activity and biotransformation studies of galloylquinic acids from Copaifera species by filamentous fungi
Orientador: em Mayo Clinic School of Medicine, U.S.A ( Professor John Charles Lieske)
com Professor Jairo Kenupp Bastos. Coorientador: Professor John Charles Lieske. Bolsista do(a): The World Academy of Sciences, TWAS-CNPQ, Itália.

Mestrado em Pharmaceutical Sciences

2010 - 2012

Alexandria University
Título: Cytotoxicity, Antiviral and Tissue Culture-based Biotransformation Study of Berberis vulgaris (L.), Ano de Obtenção: 2012
Orientador: Prof. Fathy Kandeel El-Fiky
Coorientador: Prof. Doaa Ghareeb. Bolsista do(a): Science and Technology Development Fund, STDF, Egito.

Graduação em Pharmaceutical Sciences

2003 - 2008

Alexandria University

Pós-doutorado

2019

Pós-Doutorado. , Universitat de Barcelona, UB, Espanha. , Bolsista do(a): Marie Curie European Horizon 2020 Co-fund, MSCA, Espanha.

Formação complementar

2011 - 2011

Gas Chromatography/Mass Spectroscopy Management. (Carga horária: 24h). , University of Mansoura, Faculty of Science, Department of Chemistry, MU, Egito.

2010 - 2010

Hands on Basic Techniques of Cellular Immunology a. (Carga horária: 40h). , Alexandria University, AU, Egito.

2009 - 2009

Biological Health Hazards. (Carga horária: 3h). , Institute of Graduate Studies and Research, University of Alexandria, IGSR, Egito.

2009 - 2009

Introduction to Environmental Toxicology. (Carga horária: 3h). , Institute of Graduate Studies and Research, University of Alexandria, IGSR, Egito.

2009 - 2009

Applied Ecology. (Carga horária: 3h). , Institute of Graduate Studies and Research, University of Alexandria, IGSR, Egito.

2007 - 2007

Multidisciplinary Pharmaceutical Training. (Carga horária: 42h). , Arab Company for Gelatin and Pharmaceutical Products, certified ISO 9001, ACGPP, Egito.

2007 - 2007

Training. (Carga horária: 7h). , Pharco Pharmaceutical Company, Alexandria, PPC, Egito.

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Espanhol

Compreende Razoavelmente, Fala Razoavelmente, Lê Razoavelmente, Escreve Pouco.

Português

Compreende Bem, Fala Pouco, Lê Bem, Escreve Pouco.

Francês

Compreende Razoavelmente, Fala Razoavelmente, Lê Razoavelmente, Escreve Razoavelmente.

Árabe

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Áreas de atuação

Grande área: Ciências da Saúde / Área: Farmácia / Subárea: Farmacognosia.

Grande área: Ciências Biológicas / Área: Farmacologia / Subárea: Pharmacological and biological activities of natural products.

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biotechnology, cell culture and biotransformation.

Participação em eventos

American Society of Nephrology Meeting. The Synthesized Plant Metabolite 3,4,5-Tri-O-Galloylquinic Acid Methyl Ester Inhibits Calcium Oxalate Crystal Growth in a Drosophila Model, Downregulates Renal Cell Surface Annexin A1 Expression, and Decreases Crystal Adhesion to Cells. 2017. (Congresso).

Pharmacy Up to Date Conference, at Kafrelshikh University.Anti-HCV of Berberis vulgaris (L.). 2014. (Encontro).

IUFRO Tree Biotechnology. Berberine and Berberrubine by Cell Suspension Cultures of Dodonaea Viscosa and Ocimum basilicum. 2013. (Congresso).

TWAS-ARO.Cytotoxic, Anti-HCV, Anticholinesterase and Antioxidant Activities of the Ethanolic Extract of Berberis vulgaris roots, Berberine, Di-berberine sulfate and Berberrubine. 2013. (Encontro).

BioVisionAlexandria. 2012. (Congresso).

Nanotechnology and its Applications. 2009. (Oficina).

Nanotechnology and Nano Gold Particles. 2009. (Seminário).

Diabetes Day conference. 2006. (Feira).

Produções bibliográficas

ABD EL-SALAM, MOHAMED ; FURTADO, NIEGE ; HASKIC, ZEJFA ; LIESKE, JOHN ; BASTOS, JAIRO . Antiurolithic activity and biotransformation of galloylquinic acids by Aspergillus alliaceus ATCC10060, Aspergillus brasiliensis ATCC 16404, and Cunninghamella elegans ATCC 10028b. BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY , v. 18, p. 101012, 2019.
RIBEIRO, VICTOR PENA ; ARRUDA, CAROLINE ; ABD EL-SALAM, MOHAMED ; BASTOS, JAIRO KENUPP . Brazilian medicinal plants with corroborated anti-inflammatory activities: a review. PHARMACEUTICAL BIOLOGY , v. 56, p. 253-268, 2018.
ABD EL-SALAM, MOHAMED ; BASTOS, JAIRO KENUPP ; HAN, JING JING ; PREVIDI, DANIEL ; COELHO, EDUARDO B. ; DONATE, PAULO M ; ROMERO, MICHAEL F. ; LIESKE, JOHN . The Synthesized Plant Metabolite 3,4,5-Tri-O-Galloylquinic Acid Methyl Ester Inhibits Calcium Oxalate Crystal Growth in a Drosophila Model, Downregulates Renal Cell Surface Annexin A1 Expression, and Decreases Crystal Adhesion to Cells. JOURNAL OF MEDICINAL CHEMISTRY , v. 61, p. 1609-1621, 2018.
Mohamed Abd El-Salam ; MEKKY, H. ; EMB El-Naggar ; GHAREEB, D. ; EL-DEMELLAWY, M.Maha El-Demellawy ; FIKY, F. E.Fathy El Fiky . BIOLOGICAL ACTIVITIES OF BERBERIS VULGARIS CONSTITUENTS: CYTOTOXICITY, ANTIHEPATITIS C VIRUS AND ANTI-ACETYLCHOLINE ESTERASE. JOURNAL OF PHARMACEUTICAL BIOLOGY , v. 2, p. 89-97, 2016.
ABD EL-SALAM, M. ; MEKKY, H. ; EL-NAGGAR, E.M.B. ; GHAREEB, D. ; EL-DEMELLAWY, M. ; EL-FIKY, F. . Hepatoprotective properties and biotransformation of berberine and berberrubine by cell suspension cultures of Dodonaea viscosa and Ocimum basilicum. South African Journal of Botany , v. 97, p. 191-195, 2015.
Mohamed Abd El-Salam ; Jairo K. Bastos ; HAN, J. J. ; PREVIDI, D. ; DONATES, P. ; ROMERO, M. ; LIESKE, J. . The plant 3,4,5-tri-O-galloyl quinic acid methyl ester inhibits calcium oxalate crystals growth in a Drosophila model and decreases renal cell Annexin A1 surface expression and crystal adhesion. 2017. (Apresentação de Trabalho/Conferência ou palestra).
ABD EL-SALAM, MOHAMED ; BASTOS, JAIRO KENUPP ; PREVIDI, D. ; DONATE, PAULO M . Efficient synthesis and characterization of the natural polyphenolic 3,4,5-tri-O-galloylquinic acid methyl ester as a potential bioactive antiurolithic candidate. 2017. (Apresentação de Trabalho/Conferência ou palestra).
ABD EL-SALAM, M. ; GHAREEB, D. ; MEKKY, H. ; EL-NAGGAR, E.M.B. ; EL-DEMELLAWY, M.Maha El-Demellawy ; FIKY, F. E.Fathy El Fiky . Cytotoxic, Anti-HCV, Anticholinesterase and Antioxidant Activities of the Ethanolic Extract of Berberis vulgaris roots, Berberine, Di-berberine sulfate and Berberrubine. 2013. (Apresentação de Trabalho/Conferência ou palestra).
Mohamed A. Abd El-Salam ; GHAREEB, D. ; MEKKY, H. ; EL-NAGGAR, E.M.B. ; EL-DEMELLAWY, M.Maha El-Demellawy ; FIKY, F. E.Fathy El Fiky . Biotransformation of Berberine and Berberrubine by Cell Suspension Cultures of Dodonaea viscosa and Ocimum basilicum. 2013. (Apresentação de Trabalho/Conferência ou palestra).
GHAREEB, D. ; Mohamed A. Abd El-Salam . In vivo generation of splenic dendritic cell subsets by Berberis vulgaris extract. 2011. (Apresentação de Trabalho/Conferência ou palestra).

Prêmios

2018

TRAVEL ALLOWANCE Grant for Marie Sklodowska-Curie Individual Fellowship applicants living outside Belgium - Master class at KU Leuven, Leuven, BELGIUM, KU-Leuven, Belgium.

2017

American Society of Nephrology (ASN) Kidney STARS Award recipient, New Orleans, U.S.A (https://www.asn-online.org/grants/travel/recipients.aspx?app=MSR), ASN, New Orleans, USA.

2017

Best Presented Poster (grant of 1000 $R) - PhD Research work, University of Sao Paulo, Department of Pharmaceutical Sciences.

2015

BIOVISION Next/TWAS/Université de Lyon/Pulsalys SATT Lyon St-EtBIOVISION Next/TWAS/Université de Lyon/Pulsalys SATT Lyon St-Etienne Awarienne Award, in recognition of the most innovative PhD Project, University of Lyon, FRANCE.

2015

TWAS-CNPq Full PhD Fellowship, Trieste, Italy in Collaboration with University of Sao Paulo, Brazil.

2007

Certificate of Merit for the presentation of scientific work entitled " Bird Flu ", Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria.

2007

Certificate of Merit for the presentation of scientific work entitle " Acne ", Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria.

2007

Full mark merit regarding the presentation entitled " Familial Hypertension ", Department of Pharmacology, Faculty of Pharmacy, University of Alexandria.

Histórico profissional

Endereço profissional

Faculty of Pharmacy, Delta University for Science and Technology, Department of Pharmacognosy. , International Coastal Road in front of Industrial Area., Gamasa, Mansoura, Dakahlia Governorate, - Egito - Caixa-postal: 08015, Telefone: (02050) 2770140, Ramal: 02050, Fax: (02050) 2770145, URL da Homepage:

Experiência profissional

2018 - Atual

Faculty of Pharmacy, Delta University for Science and Technology

Vínculo: Servidor Público, Enquadramento Funcional: Lecturer of Pharmacognosy (on a study leave), Regime: Dedicação exclusiva.

2013 - 2015

Faculty of Pharmacy, Delta University for Science and Technology

Vínculo: Servidor Público, Enquadramento Funcional: Assistant Lecturer of Pharmacognosy, Carga horária: 18, Regime: Dedicação exclusiva.

Outras informações:
-Academic Advisor of 30 undergraduate pharmacy students -Assisting in teaching undergraduate students, courses ranging in size from 280-400 students. -Assisting in course material preparations including laboratory experiments, lectures, exams, homework, and practice problems. -Led weekly laboratory and/or problem-solving and for undergraduate students. -Supervised students in final projects, graded exams and weekly homework. - Teaching the following courses: *Course (role): Phytochemistry-1 (Instructor) Duties: Prepared and presented practical classes Classes Given:Two per/week *Course (role): Pharmacognosy-1, PG212 (Instructor) Duties: Prepared and presented practical classes Classes Given:Two per/week *Course (role): Pharmacognosy-2, PG313 (Instructor) Duties: Prepared and presented practical classes Classes Given: Two per/week *Course (role): Botany, PG111 (Lab instructor) Duties: Prepared and presented practical classes Classes Given: Two per/week *Course (role): General Microbiology, MB 201; Histology, PB 203; *Course: Pharmaceutical Organic Chemistry-1, PC 111 (Lab instructor) Classes Given: Two per/week Duties:Presented and helped in practical classes Classes Given: One per/week

2010 - 2012

Medical Technology Centre, Medical Research Institute, UA

Vínculo: Civil servant, Enquadramento Funcional: Laboratory Instructor, Carga horária: 30, Regime: Dedicação exclusiva.

Outras informações:
Instructing and demonstrating: -Basic techniques in mammalian cell culture for researchers, postgraduate and undergraduate students.

2010 - 2010

Department of Biochemistry, Faculty of Science, University of Alexandria

Vínculo: Civil servant, Enquadramento Funcional: Laboratory Instructor, Carga horária: 48

Outras informações:
Demonstarting in the training course of ?Biological Fluids between Routine Laboratory Investigations and New Modern Technology?, an intensive 6-Days workshop on Biological Fluids Analysis.

2010 - 2010

Genetic Engineering and Biotechnology Research Institute

Vínculo: Civil servant, Enquadramento Funcional: Organizer and Lab instructor, Carga horária: 60

Outras informações:
Instructing at the workshop entitled ?Bioassays of Medicinal Plants? for researchers, postgraduate and undergraduate students.

2010 - 2012

Alexandria University

Vínculo: Civil servant, Enquadramento Funcional: Research Assistant, Carga horária: 25

2008 - 2010

Alexandria University

Vínculo: Formal labor contract, Enquadramento Funcional: Teaching Assistant, Carga horária: 21