Felipe Leal Valentim

Pós-doutorado

Formação complementar

Idiomas

Áreas de atuação

Participação em eventos

Produções bibliográficas

• LEAL-VALENTIM, FELIPE ; Océane Konza ; Alexia Velasquez ; Ahmed Saadawi ; Nidhiben Patel ; Roberta Lorenzon ; Nicolas Tchitchek ; Encarnita Mariotti-Ferrandiz ; David Klatzmann ; Adrien Six . Transcriptomic module fingerprint reveals heterogeneity of whole blood transcriptome in type 1 diabetic patients. biorxiv , v. 1, p. 1, 2025.

• VALENTIM, FELIPE LEAL . Bioinformática, ciência de dados e biologia de sistemas para medicina de precisão. BIOINFO , v. 5, p. 25, 2025.

• LEAL-VALENTIM, FELIPE . Transcritome for Identification of Biomarkers for Diagnosis and Targeted Therapy of Type 1 Diabetes. preprints.org , v. 1, p. 1, 2025.

• GENMED Consortium ; Valentim, F.L . MORFEE: a new tool for detecting and annotating single nucleotide variants creating premature ATG codons from VCF files. bioRxiv.org - the preprint server for Biology , v. March 30, p. online, 2020.

• FRASER, KARL ; ROY, NICOLE C. ; GOUMIDI, LOUISA ; VERDU, ALEXANDRE ; SUCHON, PIERRE ; LEAL-VALENTIM, FELIPE ; TRÉGOUËT, DAVID-ALEXANDRE ; MORANGE, PIERRE-EMMANUEL ; MARTIN, JEAN-CHARLES . Plasma Biomarkers and Identification of Resilient Metabolic Disruptions in Patients With Venous Thromboembolism Using a Metabolic Systems Approach. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY , v. 40, p. 2527-2538, 2020.

• LEAL VALENTIM, FELIPE ; MOURIK, SIMON VAN ; POSÉ, DAVID ; KIM, MIN C. ; SCHMID, MARKUS ; VAN HAM, ROELAND C. H. J. ; BUSSCHER, MARCO ; SANCHEZ-PEREZ, GABINO F. ; MOLENAAR, JAAP ; ANGENENT, GERCO C. ; IMMINK, RICHARD G. H. ; VAN DIJK, AALT D. J. . A Quantitative and Dynamic Model of the Arabidopsis Flowering Time Gene Regulatory Network. Plos One , v. 10, p. e0116973, 2015.

• PAJORO, A. ; BIEWERS, S. ; DOUGALI, E. ; LEAL VALENTIM, F. ; MENDES, M. A. ; PORRI, A. ; COUPLAND, G. ; VAN DE PEER, Y. ; VAN DIJK, A. D. J. ; COLOMBO, L. ; DAVIES, B. ; ANGENENT, G. C. . The (r)evolution of gene regulatory networks controlling Arabidopsis plant reproduction: a two-decade history. Journal of Experimental Botany , v. 65, p. 4731-4745, 2014.

• BOYEN, PETER ; NEVEN, FRANK ; VAN DYCK, DRIES ; VALENTIM, FELIPE L. ; VAN DIJK, AALT D. J. . Mining Minimal Motif Pair Sets Maximally Covering Interactions in a Protein-Protein Interaction Network. IEEE/ACM Transactions on Computational Biology and Bioinformatics (Print) , v. 10, p. 73-86, 2013.

• IMMINK, R. G. H. ; POSE, D. ; FERRARIO, S. ; OTT, F. ; KAUFMANN, K. ; VALENTIM, F. L. ; DE FOLTER, S. ; VAN DER WAL, F. ; VAN DIJK, A. D. J. ; SCHMID, M. ; ANGENENT, G. C. . Characterization of SOC1's Central Role in Flowering by the Identification of Its Upstream and Downstream Regulators. Plant Physiology (Bethesda) , v. 160, p. 433-449, 2012.

• LEAL VALENTIM, FELIPE ; NEVEN, FRANK ; BOYEN, PETER ; VAN DIJK, AALT D. J. . Interactome-Wide Prediction of Protein-Protein Binding Sites Reveals Effects of Protein Sequence Variation in Arabidopsis thaliana. Plos One , v. 7, p. e47022, 2012.

• SAMPAIO, R. M. ; Felipe Leal Valentim ; SOUZA, L.de A. ; SILVA, R. M. A. . Inference Algorithms for Systems of Medical Diagnosis Aid Based on Bayesian Networks. INFOCOMP (UFLA. IMPRESSO) , v. 7, p. 90-96, 2008.

• Eduardo dos Santos Funcia ; Galo Antonio Carrillo Le Roux ; LEAL-VALENTIM, FELIPE ; Gilberto Francisco Martha de Souza . Extended Kalman filter combined with fault detection techniques for subsea oil pump predictive maintenance using simulated data. In: Conferência de Pesquisa e Inovação em Transição Energética ETRI/2025, 2025. ETRI, 2025.

• SILVA, R. M. A. ; M. C. G Resende ; P. Festa ; Felipe Leal Valentim ; J. C. Alves ; D. M. Silva ; F. S. Menezes ; BALEEIRO, G. B. ; PIRES, D. M. . GRASP with path-relinking for some molecular biology consensus problems. In: VIII Metaheuristic International Conference, 2009, Hamburgo. VIII Metaheuristic International Conference, 2009.

• SILVA, R. M. A. ; BRANDAO, F. G. ; BALEEIRO, G. B. ; Felipe Leal Valentim ; MENDONÇA, A. R. de ; PIRES, D. M. . Fuzzy and neuro-fuzzy estimates of the total height of eucalyptus trees. In: ACM Symposium on Applied Computing, 2008, Fortaleza. Proceedings of the 2008 ACM symposium on Applied computing. p. 1772-1776.

• SILVA, R. M. A. ; Felipe Leal Valentim ; ALVES, M. de C. . Bayesian approaching for Asian Suprema soybean rust incidence study in different conditions of temperatures and leaf wetness. In: Hybrid Intelligent Systems, 2007, Kaiserslautern. Hybrid Intelligent Systems, 2007. HIS 2007. 7th International Conference on, 2007. p. 101-106.

• SILVA, R. M. A. ; MENDONÇA, A. R. de ; BRANDAO, F. G. ; PIRES, D. M. ; BALEEIRO, G. B. ; OLIVEIRA, A. A. S. ; Felipe Leal Valentim ; CALEGARIO, N. . Fuzzy and Neuro-Fuzzy Modeling for Total Volume study of Eucalyptus sp. In: Hybrid Intelligent Systems, 2007, Kaiserslautern. Hybrid Intelligent Systems, 2007. HIS 2007. 7th International Conference on, 2007. p. 358-361.

• CHAVES, S. S ; SILVA, G. F. F. e ; VALENTIM, F. L. ; CHALFUN-JUNIOR, A. . A first scan at the Brazilian Coffee Genome database for microRNA prediction. In: International Conference of the Brazilian Association for Bioinformatics and computational Biology, 2009, Angra dos Reis. Proceedings of the 5 International Conference of the Brazilian Association for Bioinformatics and computational Biology, 2009.

• CHAVES, S. S ; SILVA, G. F. F. e. ; VALENTIM, F. L. ; CHALFUN-JUNIOR, A. . Busca por microRNAs em Coffea arabica, Coffea canephora e Coffea racemosa. In: XXII Congresso de Iniciação Científica da UFLA CIUFLA, 2009, Lavras. XXII Congresso de Iniciação Científica da UFLA CIUFLA, 2009.

• CHAVES, S. S. ; SILVA, G. F. F. e. ; VALENTIM, F. L. ; COELHO, C. P. ; CHALFUN-JUNIOR, A. . IDENTIFICATION OF PUTATIVE COFFEE RNAs REGULATORS OF FLORAL HOMEOTIC GENES. In: III Simpósio Brasileiro de Genética Molecular de Plantas, 2011, Ilhéus. III Simpósio Brasileiro de Genética Molecular de Planta, 2011.

• Felipe Leal Valentim ; SILVA, R. M. A. ; ALVES, M. de C. . Modelos de Redes Bayesianas para Incidência da Ferrugem Asiática, Cultivar Suprema, em Diferentes Condições de Temperatura e Molhamento Foliar. In: XXXOX Simpósio Brasileiro de Pesquisa Operacional, 2007, Fortaleza. Anais do XXXIX SBPO, 2007. p. 2677-2678.

• VALENTIM, F. L. ; Aalt-Jan van Dijk . Lecturer of Master class 'Protein Interaction site prediction'. 2012. (Apresentação de Trabalho/Outra).

• VALENTIM, F. L. ; Aalt-Jan van Dijk . Master class 'Quantitative modelling of gene regulatory network of flowering time control'. 2011. (Apresentação de Trabalho/Outra).

• VALENTIM, F. L. . Protein structure comparison via contact map alignment. 2009. (Apresentação de Trabalho/Conferência ou palestra).

• VALENTIM, F. L. . Estudo e Implementação de Algoritmos de Inferência e Aprendizado em Redes Bayesianas. 2007. (Apresentação de Trabalho/Conferência ou palestra).

• LEAL-VALENTIM, FELIPE . Transimmunom whole blood RNA-seq data from type 1 diabetic patients and healthy volunteers. Pubmed, 2020 (Pubmed GEO database).

• LEAL-VALENTIM, FELIPE ; Simon van Mourik ; David Posé ; Min Chul Kim ; Markus Schmid ; Roeland van Ham ; Marco Busscher ; Gabino Sánchez-Pérez ; Jaap Molenaar ; Richard G H Immink . Transcription profiling by array of Arabidopsis thaliana wild type (Col-0) and flowering time mutants to investigate synchronized induction of flowering 2013 (Database).

Outras produções

Projetos de pesquisa

• 2024 - 2024

  Transcriptome and entropy analysis of lung squamous cell carcinoma progression and staging, Descrição: A bolsa foi concluída, o relatório CNPQ foi entregue e o artigo foi submetido em 2025. Está sob revisão/revisão.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Felipe Leal Valentim - Integrante / Nicolas Carels - Coordenador / Carlyle Lima - Integrante.

• 2024 - Atual

  NPO6_Metodologias para inspeção baseada em risco de equipamento submarino: aplicação para sistema de bombeamento elétrico submerso., Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Felipe Leal Valentim - Coordenador / Gilberto Francisco Martha de Souza - Integrante.

• 2022 - 2023

  bioinformatics of genomic surveillance from GISAID database, Descrição: https://github.com/datasciencebioinformatics/genomicSurveillanceR. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Felipe Leal Valentim - Coordenador.

• 2020 - 2022

  PREcision MEDicine in Coronary Artery Disease An interdisciplinary and translational approach towards early detection and precise therapy of subclinical myocardial ischemia leading to coronary artery disease PREMED-CAD, Descrição: Cardiovascular disease (CVD) represents the most important cause of morbidity and mortality in the EU, and causes an enormous socioeconomic impact with almost 200 Billion Euros annual costs. Despite the knowledge on CV risk factors and several biomarkers, current, existing tools fail to adequately identify subjects at short-term risk. Therefore, innovative approaches to enhance risk assessment and early identification of "at-risk subjects" are urgently needed. Within PREMED-CAD, we will take an interdisciplinary and translational approach integrating knowledge from CAD epidemiology, imaging, bioinformatics, statistics and molecular biology. PREMED-CAD builds on existing biomarker data of distinct CAD and subclinical myocardial ischemia phenotypes, functional imaging data, epidemiological cohort data and biobanks, bioinformatical methodologies and animal models. Existing blood-based and clinical biomarkers will be integrated in a biomarker signature. This signature will be validated in atherosclerosis-prone mouse models and human cohorts. The validated signature will be translated in an ongoing existing large preventive clinical trial comprising 3,000 patients with subclinical ischemia. PREMED-CAD will enable us to 1) pave the way for affordable tools for early recognition of individuals at immediate and short-term CAD risk, 2) identify the need for interventional strategies, 3) explore the molecular pathophysiology and signature of myocardial ischemia in a comprehensive view, and 4) apply precision medicine to affected individuals using an already financed clinical trial.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Felipe Leal Valentim - Integrante / David-Alexandre Trégouët - Coordenador.

• 2016 - 2019

  Transimmunom, Descrição: Chronic inflammation, a condition present in various diseases including those with an immune component, is an important cause of morbidity/mortality in the developed world. Recent advances in the pathophysiology of autoinflammatory/autoimmune diseases have led to a re-examination of their nosology. It now appears that autoinflammatory and autoimmune diseases do not represent two distinct categories of disorders. Rather, they form a disease continuum ranging from pure autoinflammatory disorders to pure autoimmune diseases, encompassing a large panel of inflammatory diseases with some autoimmune component, and vice versa. A wide range of disorders fall into this disease category. These are rare or common disorders, whose management requires an integrated approach in which clinicians from internal medicine or medical specialties and research teams collaborate closely in translational research programs.The aims include: Aim 1: Establishment of disease healthy donor cohortsAim 2: Defining the normal ImmunomeAim 3: Defining the immunome of the different diseases studiedAim 4: Identification of novel genes involved in AISsAim 5: T repertoire analyses by deep sequencingAim 6: Data modelling Biomarker discovery. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Felipe Leal Valentim - Integrante / Adrien Six - Integrante / David Klatzmann - Coordenador., Número de produções C, T & A: 1

• 2010 - 2014

  Modelling the molecular network of flowering time control, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Felipe Leal Valentim - Coordenador / Brendan Davies - Integrante / Gerco Angenent - Integrante / Lucia Colombo - Integrante / George Coupland - Integrante / Robert Sablowski - Integrante / Birgit Lewicki-Potapov - Integrante / Pawel Krajewski - Integrante / Yves Van de Peer - Integrante / Aalt-Jan van Dijk - Integrante / Sandra Biewers - Integrante / Alice Pajoro - Integrante / Marta Mendes - Integrante / Aimone Porri - Integrante / Katharina Schiessl - Integrante / Miguel Godinho - Integrante / Pedro Madrigal Bayonas - Integrante / Evangelia Dougali - Integrante / Juliet Thompson - Integrante.

• 2010 - 2012

  Prediction of protein-protein binding motifs from Arabidopsis Interactome, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Felipe Leal Valentim - Coordenador / Frank Neven - Integrante / Peter Boyen - Integrante / Aalt-Jan van Dijk - Integrante.