Maryam Jehangir

Formação complementar

Idiomas

Áreas de atuação

Participação em eventos

Produções bibliográficas

• AHMAD, SYED FARHAN ; JEHANGIR, MARYAM ; SRIKULNATH, KORNSORN ; MARTINS, CESAR . Fish genomics and its impact on fundamental and applied research of vertebrate biology. REVIEWS IN FISH BIOLOGY AND FISHERIES , v. 10, p. 1007, 2021.

• SRIKULNATH, KORNSORN ; SINGCHAT, WORAPONG ; LAOPICHIENPONG, NARARAT ; AHMAD, SYED FARHAN ; JEHANGIR, MARYAM ; SUBPAYAKOM, NAVAPONG ; SUNTRONPONG, AORARAT ; JANGTARWAN, KORNSUANG ; PONGSANARM, TAVUN ; PANTHUM, THITIPONG ; ARIYARAPHONG, NATTAKAN ; CAMCUAN, JITLADA ; DUENGKAE, PRATEEP ; DOKKAEW, SAHABHOP ; MUANGMAI, NARONGRIT . Overview of the betta fish genome regarding species radiation, parental care, behavioral aggression, and pigmentation model relevant to humans. Genes & Genomics , v. 43, p. 91-104, 2021.

• MARTINS, CESAR ; JEHANGIR, MARYAM . A genomic glimpse of B chromosomes in cichlids. Genes & Genomics , v. 43, p. 199-208, 2021.

• AHMAD, SYED F. ; JEHANGIR, MARYAM ; CARDOSO, ADAUTO L. ; WOLF, IVAN R. ; MARGARIDO, VLADIMIR P. ; CABRAL-DE-MELLO, DIOGO C. ; O?NEILL, RACHEL ; VALENTE, GUILHERME T. ; MARTINS, CESAR . B chromosomes of multiple species have intense evolutionary dynamics and accumulated genes related to important biological processes. BMC GENOMICS , v. 21, p. 656, 2020.

• AHMAD, SYED ; SINGCHAT, WORAPONG ; JEHANGIR, MARYAM ; PANTHUM, THITIPONG ; SRIKULNATH, KORNSORN . Consequence of Paradigm Shift with Repeat Landscapes in Reptiles: Powerful Facilitators of Chromosomal Rearrangements for Diversity and Evolution (Running Title: Genomic Impact of Repeatson Chromosomal Dynamics in Reptiles). Genes , v. 11, p. 827, 2020.

• AHMAD, SYED FARHAN ; SINGCHAT, WORAPONG ; JEHANGIR, MARYAM ; SUNTRONPONG, AORARAT ; PANTHUM, THITIPONG ; MALAIVIJITNOND, SUCHINDA ; SRIKULNATH, KORNSORN . Dark Matter of Primate Genomes: Satellite DNA Repeats and Their Evolutionary Dynamics. Cells , v. 9, p. 2714, 2020.

• JEHANGIR, MARYAM ; AHMAD, SYED F. ; CARDOSO, ADAUTO L. ; RAMOS, ERICA ; VALENTE, GUILHERME T. ; MARTINS, CESAR . De novo genome assembly of the cichlid fish Astatotilapia latifasciata reveals a higher level of genomic polymorphism and genes related to B chromosomes. CHROMOSOMA , v. 128, p. 81-90, 2019.

• JEHANGIR, IRUM ; AHMAD, SYED FARHAN ; JEHANGIR, MARYAM ; JAMAL, ANWAR ; KHAN, MOMIN . Integration of bioinformatics and in vitro analysis reveal anti-leishmanial effects of azithromycin and nystatin. Current Bioinformatics , v. 14, p. 1-10, 2018.

• Ahmad FS ; Anwar, Z ; HUSSAIN, S. ; JEHANGIR, M. ; JEHANGIR, I. ; JAMAL, A. ; KHATTAK, J. Z. K. ; KHAN, A. A. . A detailed report on the specific area based percentage and diagnostic methods of hepatitis C in Khyber Pakhtunkhwa, Pakistan. Molecular and Biochemical Diagnosis , v. 2, p. 51-60, 2016.

• JEHANGIR, MARYAM ; AHMAD, SYED FARHAN . Structural Studies of Aspartic Endopeptidase pep2 from Neosartorya Fisherica Using Homolgy Modeling Techniques. International Journal on Bioinformatics & Biosciences , v. 3, p. 7-20, 2013.

• Ahmad FS ; JEHANGIR, MARYAM ; Hameed A ; KHATTAK, J. Z. K. . Molecular study of a consanguineous family with autosomal recessive mental retardation and speech disorder. Molecular Biology and Research Communication , v. 1, p. 83-93, 2012.

• JEHANGIR, M. ; CARDOSO, A. L. ; Wasko, A.P ; Coan, R.L.B ; RAMOS, E. ; MARTINS, C. ; AHMAD, SYED FARHAN ; VENTURELLI, N. B. ; OLIVEIRA, J. I. ; Nakajima, RT . Chromo Comics. 1st. ed. Botucatu: , 2016. 16p .

• MARTINS, C. ; NAKAJIMA, R. T. ; RAMOS, E. ; FANTINATTI, B. ; VALENTI, G. T. ; CARDOSO, A. ; JEHANGIR, M. ; MARQUES, D. F. ; OLIVEIRA, J. I. ; BOVOLENTA, L. A. ; VENTURELLI, N. B. ; KOCHER, T. D. . Fishing for B chromosome effects. In: 22nd Inrenational Chrosome Conference(ICC), 2018, Prague. 22nd Inrenational Chrosome Conference(ICC), 2018.

• Ahmad FS ; JEHANGIR, M. ; CARDOSO, A. ; MARTINS, C. . FISH MAPPING OF 45S rRNA AND IHHB GENES ON AUTOSOMES AND B CHROMOSOME OF CICHLID FISH ASTATOTILAPIA LATIFASCIATA. In: 5th Brazillian meeting of cytogeentics and cytogenomics, 2017, Londrina. 5th Brazillian meeting of cytogeentics and cytogenomics, 2017.

• JEHANGIR, M. ; AHMAD, S. F. ; VALENTE, G. T. ; MARTINS, C. . A coverage based study of Ihhb and 45S RNA genes in the B chromosomes of Astatotilapia latificiata to highlight polymorphism levels. In: 21st International Chromosome Conference (ICC), 2016, Foz do Iguaçu. Cytogenet Genome, 2016. v. 148. p. 83-155.

• Ahmad FS ; VALENTE, G. T. ; JEHANGIR, M. ; coan R ; MARTINS, C. . Genomic Analysis of Transposable Elements in Astyanax correntinus with Focus on B Chromosome. In: 21st International Chromosome Conference (ICC), 2016, Foz do Iguaçu, Brazil. 21st International Chromosome Conference (ICC), 2016. v. 148. p. 83-155.

• MARTINS, C. ; NAKAJIMA, R. T. ; FANTINATTI, B. ; MARQUES, D. F. ; VENTURELLI, N. B. ; JEHANGIR, MARYAM ; JEHANGIR, M. ; RAMOS, E. ; OLIVEIRA, J. I. ; AHMAD, S. F. ; CARDOSO, A. ; VALENTI, G. T. . B chromosomes in the light of functiional analysis. In: 23rd International Colloquium of animal cytogenetics and genomics in Saint-Petersburg Russia, 2018, Saint-Petersburg. 23rd International Colloquium of animal cytogenetics and genomics in Saint-Petersburg Russia, 2018.

• JEHANGIR, M. ; Ahmad FS ; VALENTE, G. T. ; RAMOS, E. ; FANTINATTI, B. ; MARTINS, C. . Assembly of the cichlid fish Astatotilapia latifasciata genome with focus in B chromosome. In: 61 ° Congresso Brasileiro de Genética, 2015, 2015, Águas de Lindoia. 61 ° Congresso Brasileiro de Genética, 2015, 2015.

• JEHANGIR, M. ; AHMAD, S. F. ; CARDOSO, ADAUTO L. ; OLIVEIRA, J. I. ; MARTINS, CESAR . Chromosome-level assembly of Astatotilapia latifasciata genome and its implications for supernumerary and sex chromosomes evolution. 2020. (Apresentação de Trabalho/Conferência ou palestra).

• JEHANGIR, M. ; AHMAD, S. F. ; CARDOSO, A. L. ; MARTINS, CESAR . Identification of CpG islands enriched genes and their transcriptomics profiling in the genome of Astatotilapia latifasciata with B chromosome. 2020. (Apresentação de Trabalho/Simpósio).

• JEHANGIR, M. ; Ahmad FS ; VALENTI, G. T. ; MARTINS, C. . A Coverage-Based Study of ihhb and 45S rRNA Genes in the B Chromosomes of Astatotilapia latifasciata to Highlight Polymorphism Levels. 2016. (Apresentação de Trabalho/Conferência ou palestra).

• JEHANGIR, M. . Genome assembly of the cichlid fish astatotilapia latifasciata with focus in population genomics of B chromosome polymorphism. 2015. (Apresentação de Trabalho/Simpósio).

• JEHANGIR, M. ; Ahmad FS ; VALENTE, G. T. ; RAMOS, E. ; MARTINS, C. . Genome assembly of the cichlid fish astatotilapia latifasciata with focus in B chromosome. 2015. (Apresentação de Trabalho/Congresso).

• JEHANGIR, M. ; JEHANGIR, M. . Homology modelling. 2010. (Apresentação de Trabalho/Seminário).

Projetos de pesquisa

• 2021 - Atual

  Isolation of B chromosome and sex-linked sequences to uncover their associated genomic rearrangements and evolutionary impact on Astatotilapia latifasciata genome, Descrição: The origins of B and sex chromosomes in cichlid fishes are among the most fundamental questions in evolutionary biology. Our understanding of the ways that these genetic materials appear and how that genetic material shapes population variation, remains incomplete. Repetitive elements, novel genes, and duplicated genes are the key sources to the new genetic material on which selection may act. Based on our previous findings (Jehangir et al. 2019), we hypothesize that the chromosomal rearrangements are part of an ongoing evolutionary process that results in a novel form of large-scale variation in B and sex chromosomes and might alter expression patterns and form novel transcripts. Here, we will use the highly rearranged genome of a cichlid fish, Astatotilpia latifasciata containing B chromosome to examine how evolutionary chromosomal rearrangements impact on gene function and regulation and to study its 3D genome organization. We will sequence the complete genome of A. latifasciata male individual with B chromosome by the PacBio SEQUEL II and Hi-C platforms to get chromosome level assembly. This project will allow generating a highly accurate annotated reference genome to uncover B and sex-linked sequences and analyze their expression level using the available RNAseq data. We propose a research plan (to be developed during 12 months internship abroad), aimed to deeply investigate B chromosome via applications of advanced comparative genomics, cytogenetics and bioinformatics methodologies. The analysis will comprise steps such as B chromosome assembly, isolation of sex chromosome sequences, comparative analysis, B chromosome associated rearrangements and validation of B and sex-linked sequences by qPCR and FISH. In addition, the centromeric regions, that are difficult to assemble, will be screened to isolate the satellite DNA of the B chromosome and sex-linked regions using fosmid cloning.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Maryam Jehangir - Integrante / Cesar martins - Integrante / SRIKULNATH, KORNSORN - Coordenador.

• 2019 - Atual

  Single molecule sequencing and chromatin conformation capture applied to B chromosome assembly in Astatotilapia latifasciata, Descrição: B chromosome (B) is extra unpaired karyotypic unit which is unique from the regular set of A chromosomes. A distinguished feature that makes the B different from the A complement is its inheritance in a non-Mendelian and irregular fashion. The current trends in omics technologies have unlocked exciting information about the genes and repeats contents on B chromosomes (Bs). The latest discoveries of genes on Bs signify that they can interact with regular chromosomes (As) and might play an important role in genome evolution. In this way, Bs have emerged as an interesting model system to study molecular evolutionary processes. But the molecular level investigation of Bs to study these phenomena, face limitations and the ongoing analysis has been hampered due to lack of high-quality sequence assemblies. Repeats pose the largest challenge for reference genome assembly, and the duplicated sequences on B chromosome are typically ignored during short sequencing assemblies. Here, we propose to perform the B chromosome assembly of a cichlid fish, Astatotilapia latifasciata and to improve the latest draft scaffolded version of its assembled genome into chromosomes level. We will assemble the B, using a combination of modern technologies, including long reads PacBio, utilizing already sequenced high coverage short Illumina reads data, and Hi-C technique followed by the validation of BioNano mapping and Florescent in situ hybridization (FISH). The final assembly will achieve superior continuity and accuracy and provide a new standard reference for the investigation of genes and repetitive sequences and B chromosome evolution. The development of this project will also enable us to trace the chromosomal events that have led to the formation of unusual B chromosome karyotypes. Finally, we will be able to recover a complete structure and genetic map of B, with deep insights on its genomic origin and function.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Maryam Jehangir - Integrante / Cesar martins - Coordenador., Financiador(es): CAPES - Centro Anhanguera de Promoção e Educação Social - Bolsa.

• 2016 - 2018

  Integration of bioinformatics and in vitro analysis reveal anti-leishmanial effects of azithromycin and nystatin, Descrição: Leishmaniasis is the major cause of mortality in under-developed countries. One of the main problems in leishmaniasis is the limited number of drug options, resistance and side effects. Such a situation requires to study the new chemical series with antileishmanial activity. We have applied a integrative approach based on computational and in vitro methods to elucidate the efficacy of different antibacterial and antifungal drugs against Leishmania tropica (KWH23). Firstly these compounds were analyzed using insilico molecular docking. This analysis showed that the nystatin and azithromycin interacted with the active site amino acids of the target protein leishmanolysin. The nystatin, followed by azithromycin, produced the lowest binding energies indicating their inhibitive activity against the target. The efficacy of the docked drugs was further validated invitro which showed that our bioinformatics based predictions completely agreed with experimental results. Stock solutions of drugs, media preparation and parasites cultures were performed according to the standard invitro protocol. We found that the half maximal inhibitory concentration (IC50) value of dosage form of nystatin (10,000,00 U) and pure nystatin was 0.0528 g/ml and 0.003 g /ml respectively. The IC50 value of combined azithromycin and nystatin (dosage and pure form) were 0.156 g/ml and 0.0023 g /ml respectively. It was observed that IC50 value of nystatin is better than azithromycin and pure form of drugs were having significant activity than dosage form of drugs. From these results it is also proven that pure drugs combination result is much better than all tested drugs results. The results of both in vitro and in silico studies clearly indicated that comparatively, nystatin is the potential candidate drug in combat against Leishmania tropica.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Maryam Jehangir - Integrante / AHMAD, SYED FARHAN - Integrante / Irum Jehangir - Integrante / Anwar Jamal - Integrante / Momin Khan - Coordenador.

• 2015 - 2017

  GENOME ASSEMBLY OF THE CICHLID FISH ASTATOTILAPIA LATIFASCIATA WITH FOCUS IN POPULATION GENOMICS OF B CHROMOSOME POLYMORPHISM, Descrição: B chromosomes (Bs) are additional to the standard regular chromosome set (As), and present in all groups of eukaryotes. A reference genome is key to understand genomics aspects of an organism. Here, we present the de novo genome assembly of the cichlid fish A. latifasciata: a well known model to study Bs. The assembly of A. latifasciata genome has not been performed so far. The main focus of this study is to analyze and assemble the A. latifasciata genome with no B (B-) and with B (B+) chromosomes. The assembled draft B- and B+ genomes comprised of 774 Mb and 781 Mb with 1.8 Mb and 2.5Mb of N50 value of scaffolds respectively, and spanning 23,391 number of genes. High coverage data with Illumina sequencing was obtained for males and females with 0B, 1B and 2B chromosomes to provide information regarding the population polymorphism of these genomes. We observed a high scale genomic diversity in all analyzed genomes showing a high rate/frequency of population polymorphism with no evident effect of B chromosome presence. However, the B specific single nucleotide polymorphisms were found in the sequences that were located on B chromosome. While, the whole-genome rearrangements (inter chromosomal translocations) were detected in B+ genome, and structural variations including insertions, deletions, inversions and duplications were predicted in a representative genomic region of B chromosome. These results bring an evidence that existence of Bs in a genome should favour the accumulations of mutations and structural polymorphisms in the amlified genomic regions present on B chromosmes. In addition, we also performed the coverage based sequence study coupled with FISH mapping which revealed: 1) the existence of high copy number of inactive Indian Hedgehog b (IHHB) gene on B chromosome emerging as a pseudogene after series of duplication events ultimately becoming a major structural component of B; 2) B chromosome have incorporated the entire 45S RNA cluster (18S ribosomal RNA, internal transcribed spacer 1, 5.8S ribosomal RNA, internal transcribed spacer 2, and 28S ribosomal RNA) from the A complement set. The assembly of A. latifasciata genome will serve as a reference for genetic analysis and the approach presented in this paper opens the perspective to advance understanding B chromosomes biology.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: / Mestrado profissional: (1) . , Integrantes: Maryam Jehangir - Integrante / Cesar martins - Coordenador., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Bolsa.

• 2010 - 2011

  STRUCTURAL STUDIES OF ASPARTIC ENDOPEPTIDASE pep2 FROM NEOSARTORYA FISHERICA USING HOMOLGY MODELING TECHNIQUES, Descrição: Aspartic endo peptidase pep2 protein of neosartorya fisherica belongs from aspartic acid proteases that depend on aspartic acid residues for their catalytic activity. Catalytic mechanism has been proposed for the hydrolysis of proteins to peptides or free amino acids. It is accomplished the putative proteolytic activity of the conidial surface. Therefore, if it is not act like an allergen itself but on the conidial surface may well play an important role in the processing or signaling to allergens and causing different rare human infections such as (lungs aspergillosis and mycotic keratitis). To understand its different aspects, 3D structure model of (AEP pep2) was generated according to the structural coordinates of template (Proteinase A) with the help of MODELLER ( 9v8) software . To validate the energy and geometry in the model used PROCHECK and web server ProSA which determines that the predicted model to be stable and flexible.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Maryam Jehangir - Integrante / Noreen Asim - Coordenador.