Lora Lee Arnold

Áreas de atuação

Produções bibliográficas

• DODMANE, P. R. ; Arnold, L.L ; PENNINGTON, K. L. ; COHEN, SAMUEL M. . Orally administered nicotine induces urothelial hyperplasia in rats and mice.. Toxicology (Amsterdam) , v. 315, p. 49-54, 2014.

• DA ROCHA, MITSCHELI SANCHES ; ARNOLD, LORA L. ; DE OLIVEIRA, MARIA LUIZA COTRIM SARTOR ; CATALANO, SHADIA M. IHLASEH ; CARDOSO, ANA PAULA FERRAGUT ; PONTES, MERIELEN G. N. ; FERRUCIO, BIANCA ; DODMANE, PUTTAPPA R. ; COHEN, SAMUEL M. ; DE CAMARGO, JOÃO LAURO V. . Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework. Critical Reviews in Toxicology , v. 44, p. 1-14, 2014.

• Arnold, L.L ; SUZUKI, SHUGO ; YOKOHIRA, M. ; KAKIUCHI-KIYOTA, S. ; PENNINGTON, K. ; COHEN, S. M. . Time Course of Urothelial Changes in Rats and Mice Orally Administered Arsenite. Toxicologic Pathology , v. 42, p. 855-862, 2014.

• DODMANE, P. R. ; ARNOLD, L. ; PENNINGTON, K. ; THOMAS, D. J. ; COHEN, S. M. . Effect of dietary treatment with dimethylarsinous acid (DMA(III)) on the urinary bladder epithelium of arsenic (+3 oxidation state) methyltransferase (As3mt) knockout and C57BL/6 wild type female mice.. Toxicology (Amsterdam) , v. 305, p. 130-135, 2013.

• YAGER, J. W. ; GENTRY, P. R. ; THOMAS, R. S. ; PLUTA, L. ; EFREMENKO, A. ; BLACK, M. ; ARNOLD, L. ; MCKIM, J. M. ; WILGA, P. ; GILL, G. ; CHOE, K. ; CLEWELL, H. J. . Evaluation of gene expression changes in human primary uroepithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites.. Environmental and Molecular Mutagenesis (Online) , v. 54, p. 92-98, 2013.

• KAKIUCHI-KIYOTA, S. ; CRABBS, T. A. ; ARNOLD, L. ; PENNINGTON, K. ; COOK, J. C. ; MALARKEY, D. E. ; COHEN, S. M. . Evaluation of expression profiles of hematopoietic stem cell, endothelial cell, and myeloid cell antigens in spontaneous and chemically induced hemangiosarcomas and hemangiomas in mice.. Toxicologic Pathology , v. 41, p. 709-721, 2013.

• WEDEL, W. R. ; MUIRHEAD, D. E. ; ARNOLD, L. ; DODMANE, P. R. ; LELE, S. M. ; MANESS-HARRIS, L. ; HOYT, R. ; COHEN, S. M. . Urothelial cell intracytoplasmic inclusions after treatment of promyelocytic leukemia with arsenic trioxide.. Toxicological Sciences (Print) , v. 134, p. 271-275, 2013.

• LIU, L. ; KAKIUCHI-KIYOTA, S. ; ARNOLD, L. ; JOHANSSON, S. L. ; WERT, D. ; COHEN, S. M. . Pathogenesis of human hemangiosarcomas and hemangiomas.. Human Pathology (Print) , v. 44, p. 2302-2311, 2013.

• COHEN, SAMUEL M. ; Arnold, L.L ; BECK, B. D. ; LEWIS, A. S. ; ELDAN, M. . Evaluation of the carcinogenicity of inorganic arsenic.. Critical Reviews in Toxicology , v. 43, p. 711-752, 2013.

• DODMANE, P. R. ; Arnold, L.L ; MUIRHEAD, D. E. ; SUZUKI, S. ; YOKOHIRA, M. ; PENNINGTON, K. L. ; DAVE, B. J. ; LU, X. ; LE, X. C. ; COHEN, SAMUEL M. . Characterization of intracellular inclusions in the urothelium of mice exposed to inorganic arsenic.. Toxicological Sciences (Print) , v. 137, p. 36-46, 2013.

• DODMANE, P. R. ; Arnold, L.L ; KAKIUCHI-KIYOTA, S. ; QIU, F. ; LIU, X. ; RENNARD, S. I. ; COHEN, S. M. . Cytotoxicity and gene expression changes induced by inorganic and organic trivalent arsenicals in human cells.. Toxicology (Amsterdam) , v. 312, p. 18-29, 2013.

• CHEN, B. ; LU, X. ; SHEN, S. ; Arnold, L.L ; COHEN, S. M. ; LE, X. C. . Arsenic Speciation in the Blood of Arsenite-Treated F344 Rats. Chemical Research in Toxicology , v. 26, p. 952-962, 2013.

• DA ROCHA, MITSCHELI S. ; ARNOLD, LORA L. ; DODMANE, PUTTAPPA R. ; PENNINGTON, KAREN L. ; QIU, FANG ; DE CAMARGO, JOÃO LAURO V. ; COHEN, SAMUEL M. . Diuron metabolites and urothelial cytotoxicity: In vivo, in vitro and molecular approaches. Toxicology (Amsterdam) , v. 314, p. 238-246, 2013.

• DA ROCHA, M. S. ; DODMANE, P. R. ; ARNOLD, L. L. ; PENNINGTON, K. L. ; ANWAR, M. M. ; ADAMS, B. R. ; TAYLOR, S. V. ; WERMES, C. ; ADAMS, T. B. ; COHEN, S. M. . Mode of Action of Pulegone on the Urinary Bladder of F344 Rats. Toxicological Sciences (Print) , v. 128, p. 1-8, 2012.

• OBEROI, H. S. ; NUKOLOVA, N. V. ; LAQUER, F. C. ; POLUEKTOVA, L. Y. ; HUANG, J. ; ALNOUTI, Y. ; YOKOHIRA, M. ; ARNOLD, L. ; KABANOV, A. V. ; COHEN, S. M. ; BRONICH, T. K. . Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice.. International Journal of Nanomedicine (Online) , v. 7, p. 2557-2571, 2012.

• SUZUKI, S. ; ARNOLD, L. ; PENNINGTON, K. ; KAKIUCHI-KIYOTA, S. ; CHEN, B. ; LU, X. ; LE, X. C. ; COHEN, S. M. . Effects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium.. Toxicology (Amsterdam) , v. 299, p. 155-159, 2012.

• DA ROCHA, M. S. ; ARNOLD, L. L. ; PENNINGTON, K. L. ; MUIRHEAD, D. ; DODMANE, P. R. ; ANWAR, M. M. ; BATTALORA, M. ; DE CAMARGO, J. L. V. ; COHEN, S. M. . Diuron-Induced Rat Bladder Epithelial Cytotoxicity. Toxicological Sciences (Print) , v. 130, p. 281-288, 2012.

• COHEN, S. M. ; ARNOLD, L. . Chemical carcinogenesis.. Toxicological Sciences , v. 120, p. S76-S92, 2011.

• YOKOHIRA, M. ; ARNOLD, L. ; LAUTRAITE, S. ; SHEETS, L. ; WASON, S. ; STAHL, B. ; EIGENBERG, D. ; PENNINGTON, K. ; KAKIUCHI-KIYOTA, S. ; COHEN, S. M. . The effects of oral treatment with transfluthrin on the urothelium of rats and its metabolite, tetrafluorobenzoic acid on urothelial cells in vitro.. Food and Chemical Toxicology , v. 49, p. 1215-1226, 2011.

• YOKOHIRA, M. ; ARNOLD, L. ; PENNINGTON, K. ; SUZUKI, S. ; KAKIUCHI-KIYOTA, S. ; HERBIN-DAVIS, K. ; THOMAS, D. J. ; COHEN, S. M. . Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice. Toxicological Sciences , v. 121, p. 257-266, 2011.

• KAKIUCHI-KIYOTA, S. ; ARNOLD, L. ; YOKOHIRA, M. ; KOZA-TAYLOR, P. ; SUZUKI, S. ; VARNEY, M. ; PENNINGTON, K. ; COHEN, S. M. . Evaluation of direct and indirect effects of the PPARγ agonist troglitazone on mouse endothelial cell proliferation.. Toxicologic Pathology , v. 39, p. 1032-1045, 2011.

• KAKIUCHI-KIYOTA, S. ; ARNOLD, L. ; YOKOHIRA, M. ; SUZUKI, S. ; PENNINGTON, K. ; COHEN, S. M. . Evaluation of PPARγ agonists on rodent endothelial cell proliferation.. Toxicology (Amsterdam) , v. 287, p. 91-98, 2011.

• CHEN, B. ; ARNOLD, L. ; COHEN, S. M. ; THOMAS, D. J. ; LE, X. C. . Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water.. Toxicological Sciences , v. 124, p. 320-326, 2011.

• SUZUKI, S. ; ARNOLD, L. ; PENNINGTON, K. ; CHEN, B. ; NARANMANDURA, H. ; LE, X. C. ; COHEN, S. M. . Dietary administration of sodium arsenite to rats: Relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium. Toxicology and Applied Pharmacology , v. 244, p. 99-105, 2010.

• SUZUKI, S. ; ARNOLD, L. ; PENNINGTON, K. ; KAKIUCHI-KIYOTA, S. ; WEI, M. ; WANIBUCHI, H. ; COHEN, S. M. . Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat.. Toxicological Sciences , v. 113, p. 349-357, 2010.

• YOKOHIRA, M. ; ARNOLD, L. ; PENNINGTON, K. ; SUZUKI, S. ; KAKIUCHI-KIYOTA, S. ; HERBIN-DAVIS, K. ; THOMAS, D. J. ; COHEN, S. M. . Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report.. Toxicology and Applied Pharmacology , v. 246, p. 1-7, 2010.

• TANNEHILL-GREGG, S. H. ; DOMINICK, M. A. ; REISINGER, A. J. ; MOEHLENKAMP, J. D. ; WAITES, C. R. ; STOCK, D. A. ; SANDERSON, T. P. ; COHEN, S. M. ; ARNOLD, L. ; SCHILLING, B. E. . Strain-related differences in urine composition of male rats of potential relevance to urolithiasis.. Toxicologic Pathology , v. 37, p. 293-305, 2009.

• SUZUKI, S. ; ARNOLD, L. ; PENNINGTON, K. ; KAKIUCHI-KIYOTA, S. ; COHEN, S. M. . Effects of co-administration of dietary sodium arsenite and an NADPH oxidase inhibitor on the rat bladder. Toxicology (Amsterdam) , v. 261, p. 41-46, 2009.

• SUZUKI, S. ; ARNOLD, L. ; PENNINGTON, K. ; CHEN, B. ; LE, X. C. ; COHEN, S. M. . Effects of co-administration of dietary sodium arsenite and an epidermal growth factor receptor inhibitor on the rat bladder epithelium. Toxicology Letters , v. 187, p. 124-129, 2009.

• KAKIUCHI-KIYOTA, SATOKO ; VETRO, JOSEPH A. ; SUZUKI, SHUGO ; VARNEY, MICHELLE L. ; HAN, HUAI-YUN ; NASCIMENTO, MERIELEN ; PENNINGTON, KAREN L. ; ARNOLD, LORA L. ; SINGH, RAKESH K. ; COHEN, SAMUEL M. . Effects of the PPARγ agonist troglitazone on endothelial cells in vivo and in vitro: Differences between human and mouse. Toxicology and Applied Pharmacology , v. 237, p. 83-90, 2009.

• COHEN, S. M. ; Arnold, L.L ; SUZUKI, S. . Urinary tract calculi and bladder tumors. Cancer Risk Assessment. 1ed.: , 2010, v. , p. 501-512.

• DODMANE, P. R. ; Arnold, L.L ; PENNINGTON, K. L. ; COHEN, SAMUEL M. . Orally administered nicotine induces urothelial hyperplasia in rats and mice.. In: 53rd Annual Meeting and ToxExpo, 2014, Phoenix. The Toxicologist, 2014.

• KAKIUCHI-KIYOTA, S. ; CRABBS, T. A. ; Arnold, L.L ; PENNINGTON, K. L. ; COOK, J. C. ; MALARKEY, D. E. ; COHEN, SAMUEL M. . Expression profiles of hematopoietic stem cell, endothelial cell, and myeloid cell antigens in spontaneous and chemically induced hemangiomas (HA) and hemangiosarcomas (HS) in mice. In: 52nd Annual Meeting and ToxExpo, 2013, San Antonio. The Toxicologist, 2013.

• Arnold, L.L ; DODMANE, P. R. ; PENNINGTON, K. L. ; COHEN, SAMUEL M. . Effects of treatment with dimethylarsinous acid (DMAIII) on the urinary bladder epithelium of female arsenic methyltransferase (As3mt) knockout mice and wild type mice.. In: 52nd Annual Meeting and ToxExpo, 2013, San Antonio. The Toxicologist, 2013.

• DODMANE, P. R. ; Arnold, L.L ; PENNINGTON, K. L. ; COHEN, SAMUEL M. . Gene expression changes induced by various arsenicals in vitro.. In: 52nd Annual Meeting and ToxExpo, 2013, San Francisco. The Toxicologist, 2013.

• DODMANE, P. R. ; DA ROCHA, M. S. ; Arnold, L.L ; PENNINGTON, K. L. ; ANWAR, M. M. ; ADAMS, B. R. ; TAYLOR, S. V. ; ADAMS, T. B. ; COHEN, SAMUEL M. . Evaluation of the urothelial cytotoxicity of pulegone. In: 51st Annual Meeting and ToxExpo, 2012, San Francisco. The Toxicologist, 2012.

• DA ROCHA, M. S. ; Arnold, L.L ; PENNINGTON, K. L. ; ANWAR, M. M. ; BATTALORA, M. ; DE CAMARGO, J. L. V. ; COHEN, SAMUEL M. . Evaluation of diuron s mode of action: in vivo and in vitro approaches. In: 51st Annual Meeting and ToxExpo, 2012, San Francisco. The Toxicologist, 2012.

• DA ROCHA, M. S. ; Arnold, L.L ; PENNINGTON, K. L. ; ANWAR, M. M. ; BATTALORA, M. ; DE CAMARGO, J. L. V. ; COHEN, SAMUEL M. . Evaluation of diuron s mode of action: in vivo and in vitro approaches. In: 51st Annual Meeting and ToxExpo, 2012, San Francisco. The Toxicologist, 2012.

• YOKOHIRA, M. ; Arnold, L.L ; PENNINGTON, K. L. ; SUZUKI, SHUGO ; KAKIUCHI-KIYOTA, S. ; HERBIN-DAVIS, K. ; THOMAS, D. J. ; IMAIDA, K. ; COHEN, SAMUEL M. . Severe urinary bladder cytotoxicity and regenerative hyperplasia with dose response induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice.. In: 50th Annual Meeting and ToxExpo, 2011, Washington, DC. The Toxicologist, 2011. v. 120.

• KAKIUCHI-KIYOTA, S. ; Arnold, L.L ; KOZA-TAYLOR, P. ; SUZUKI, SHUGO ; COHEN, SAMUEL M. . Analysis of peroxisome proliferator-activated receptor gamma (PPARγ) agonist troglitazone-induced transcriptional changes in mouse endothelial cells.. In: 50th Annual Meeting and ToxExpo, 2011, Washington, DC. The Toxicologist, 2011. v. 120.

• COHEN, SAMUEL M. ; Arnold, L.L ; LAUTRAITE, S. ; SHEETS, L. ; WASON, S. ; STAHL, B. ; EIGENBERG, D. ; PENNINGTON, K. L. ; KAKIUCHI-KIYOTA, S. ; YOKOHIRA, M. . The effects of oral treatment with transfluthrin on the bladder epithelium of rats and mice and its metabolite, tetrafluorobenzoic acid on urothelial cells in vitro.. In: 50th Annual Meeting and ToxExpo, 2011, Washington, DC. The Toxicologist, 2011. v. 120.

• Arnold, L.L ; KAKIUCHI-KIYOTA, S. ; PENNINGTON, K. L. ; COHEN, SAMUEL M. . Cytotoxicity of arsenicals on human bronchial epithelial cells in vitro. In: 50th Annual Meeting and ToxExpo, 2011, Washington, DC. The Toxicologist, 2011. v. 120.

• KAKIUCHI-KIYOTA, S. ; SINGH, RAKESH K. ; VETRO, JOSEPH A. ; VARNEY, MICHELLE L. ; HAN, HUAI-YUN ; SUZUKI, SHUGO ; PENNINGTON, K. L. ; Arnold, L.L ; COHEN, SAMUEL M. . Evaluation of the effects of the PPARγ agonist troglitazone on cytotoxicity and mitogenesis of endothelial cells: Differences between human and mouse.. In: 48thAnnual Meeting and ToxExpo, 2009, Baltimore. The Toxicologist, 2009. v. 108.

• SUZUKI, SHUGO ; Arnold, L.L ; PENNINGTON, K. L. ; CHEN, B. ; LE, X. C. ; COHEN, SAMUEL M. . Dose effects of arsenite on rodent bladder urothelium. In: 48th Annual Meeting and ToxExpo, 2009, Baltimore. The Toxicologist, 2009. v. 108. p. 1646.

• KAKIUCHI-KIYOTA, S. ; YOKOHIRA, M. ; SUZUKI, SHUGO ; Arnold, L.L ; PENNINGTON, K. L. ; SINGH, RAKESH K. ; COHEN, SAMUEL M. . Effects of peroxisome proliferator-activated receptor gamma (PPAR γ) agonists on endothelial cells: differences between sarcomagenic troglitazone and non-sarcomagenic pioglitazone.. In: 48th Annual Meeting and ToxExpo, 2009, Baltimore. The Toxicologist, 2009. v. 114. p. 516.

• YOKOHIRA, M. ; WEI, M. ; WANIBUCHI, H. ; SUZUKI, SHUGO ; PENNINGTON, K. L. ; KAKIUCHI-KIYOTA, S. ; Arnold, L.L ; COHEN, SAMUEL M. . Effects of oral administration of pioglitazone, sodium saccharin or sodium o-phenylphenate on the expression of oncomodulin in the bladder epithelium of male F344 rats. In: 48th Annual Meeting and ToxExpo, 2009, Baltimore. The Toxicologist, 2009. v. 114. p. 1300.

• Arnold, L.L ; YOKOHIRA, M. ; PENNINGTON, K. L. ; SUZUKI, SHUGO ; KAKIUCHI-KIYOTA, S. ; HERBIN-DAVIS, K. ; THOMAS, D. J. ; COHEN, SAMUEL M. . Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. In: 48th Annual Meeting and ToxExpo, 2009, Baltimore. The Toxicologist, 2009. v. 114.

• DA ROCHA, M. S. ; Arnold, L.L ; DODMANE, P. R. ; DE OLIVEIRA, MARIA LUIZA COTRIM SARTOR ; CARDOSO, ANA PAULA FERRAGUT ; NASCIMENTO, MERIELEN ; PENNINGTON, K. L. ; MUIRHEAD, D. ; QIU, FANG ; COHEN, SAMUEL M. ; DE CAMARGO, J. L. V. . Elucidating The Carcinogenic Mode of Action of Diuron on Rat Urothelium.. 2014. (Apresentação de Trabalho/Congresso).

• FENG, S. ; DING, S. J. ; DODMANE, P. R. ; SCOTCHEN, J. ; Arnold, L.L ; YOUNG, N. L. ; MARSHALL, A. G. ; COHEN, SAMUEL M. . Identification of the interaction of trivalent arsenicals with metallothionein by use of ultrahigh resolution mass spectrometry.. 2013. (Apresentação de Trabalho/Conferência ou palestra).

• LIU, X. ; KAKIUCHI-KIYOTA, S. ; Arnold, L.L ; JOHANSSON, S. L. ; WERT, D. ; COHEN, SAMUEL M. . Pathogenesis of human hemangiosarcomas. 2013. (Apresentação de Trabalho/Congresso).

• DA ROCHA, M. S. ; Arnold, L.L ; PENNINGTON, K. L. ; DODMANE, P. R. ; ANWAR, M. M. ; MUIRHEAD, D. ; DE CAMARGO, J. L. V. ; COHEN, SAMUEL M. . Evaluation of diuron s mode of action. 2012. (Apresentação de Trabalho/Simpósio).

• DA ROCHA, M. S. ; Arnold, L.L ; PENNINGTON, K. L. ; DODMANE, P. R. ; ANWAR, M. M. ; DE OLIVEIRA, MARIA LUIZA COTRIM SARTOR ; MUIRHEAD, D. ; DE CAMARGO, J. L. V. ; COHEN, SAMUEL M. . Diuron urothelium toxicity. 2012. (Apresentação de Trabalho/Congresso).

• CLEWELL, H. J. ; EFREMENKO, A. ; BLACK, M. ; THOMAS, R. S. ; WILGA, P. ; Arnold, L.L ; GENTRY, P. R. ; YAGER, J. W. . Arsenic-induced gene expression changes in primary human uroepithelial cells. 2011. (Apresentação de Trabalho/Congresso).

• YAGER, J. W. ; EFREMENKO, A. ; BLACK, M. ; THOMAS, R. S. ; WILGA, P. ; Arnold, L.L ; GENTRY, P. R. ; CLEWELL, H. J. . Genomic changes in primary human uroepithelial cells following 24 hour exposure to mixtures of arsenite and its principal methylated metabolites. 2011. (Apresentação de Trabalho/Congresso).

• YAGER, J. W. ; CLEWELL, H. J. ; THOMAS, R. S. ; EFREMENKO, A. ; BLACK, M. ; GILL, G. ; WAGNER, H. ; MCKIM, J. M. ; WILGA, P. ; COHEN, SAMUEL M. ; Arnold, L.L ; GENTRY, P. R. . Evaluation of genomic changes in human primary uroepithelial cells following exposures to inorganic arsenic and it s methylated metabolites.. 2010. (Apresentação de Trabalho/Conferência ou palestra).

• CHEN, B. ; MCKNIGHT-WHITFORD, A. ; Arnold, L.L ; SUZUKI, SHUGO ; PENNINGTON, K. L. ; COHEN, SAMUEL M. ; LE, X. C. . Determination of arsenic species in urine and serum samples from rats exposed to arsenite.. 2009. (Apresentação de Trabalho/Conferência ou palestra).

Projetos de pesquisa

• 2013 - Atual

  National Institutes of Health (2P20GM103480-06), Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Lora Lee Arnold - Coordenador / Samuel M. Cohen - Integrante / Tatiana Bronich - Integrante.

• 2012 - 2013

  Investigations on the Mode of Action of Inorganic Arsenic Carcinogenesis, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Lora Lee Arnold - Integrante / Samuel M. Cohen - Coordenador.

• 2012 - 2013

  Cytotoxicity, proliferation and apoptosis in mouse and human endothelial cells, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Lora Lee Arnold - Integrante / Samuel M. Cohen - Coordenador.

• 2012 - 2013

  Mechanistic Study for Carcinogenicity of DSP-8658 in Male Rats. Follow-up Urinalysis Evaluation in Rats, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Lora Lee Arnold - Integrante / COHEN, SAMUEL M. - Coordenador.