Philip Newsholme

Prof. Philip Newsholme estudou na Gosford Hill School, Kidlington, Oxford, Universidade de Birmingham e Universidade de Oxford no Reino Unido. Realizou sua formação de pós-doutorado no Departamento de Química Biológica da Universidade da Califórnia, Davis, CA, EUA e no Departamento de Bioquímica Clínica da Universidade de Cambridge, Reino Unido. Philip Newsholme mudou-se para o University College Dublin, Irlanda, em 1993, onde ele montou uma equipe de pesquisa que investiga nutrientes e a regulação endócrina e imunológica da secreção de insulina, área de pesquisa fundamental para a compreensão da fisiopatologia do diabetes tipo-2. Philip Newsholme mudou-se para assumir o cargo de Professor e Diretor da Faculdade de Ciências Biomédicas da Universidade Curtin, Perth WA, em setembro de 2011.

Informações coletadas do Lattes em 04/11/2022

Acadêmico

Formação acadêmica

Doutorado em D Phil In Biochemistry

1984 - 1987

University of Oxford
Título: Glutamine and immune fucntion in motor activity
Orientador: Eric Arthur Newsholme

Graduação em Biology

1979 - 1983

University of Oxford

Pós-doutorado

1990 - 1992

Pós-Doutorado. , University of Cambridge, CAM, Inglaterra.

1987 - 1990

Pós-Doutorado. , Ucla Medical School At Davis, UCLA,DAVIS, Estados Unidos.

Produções bibliográficas

2016 CARLESSI, RODRIGO ; WALZ, NIKITA ; CRUZAT, VINICIUS FERNANDES ; KEANE, KEVIN ; JOHN, ABRAHAM N. ; JIANG, FANG-XU ; CARNAGARIN, REVATHY ; DASS, CRISPIN R. ; NEWSHOLME, Philip . Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets. Molecular and Cellular Endocrinology (Print) , v. xx, p. xxx, 2016.
PERUMAL, VANATHI ; POHL, SEBASTIAN ; KEANE, KEVIN N. ; ARFUSO, FRANK ; NEWSHOLME, Philip ; FOX, SIMON ; DHARMARAJAN, ARUN . Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells. Experimental Cell Research , v. xx, p. xxx, 2016.
VERDILE, GIUSEPPE ; KEANE, KEVIN N. ; CRUZAT, VINICIUS F. ; MEDIC, SANDRA ; SABALE, MIHEER ; ROWLES, JOANNE ; WIJESEKARA, NADEEJA ; MARTINS, RALPH N. ; FRASER, PAUL E. ; NEWSHOLME, Philip . Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer?s Disease. Mediators of Inflammation (Print) , v. 2015, p. 1-17, 2015.
FIRNS, SARAH ; CRUZAT, VINICIUS FERNANDES ; KEANE, KEVIN NOEL ; JOESBURY, KAREN A. ; LEE, ANDY H. ; NEWSHOLME, Philip ; YOVICH, JOHN L. . The effect of cigarette smoking, alcohol consumption and fruit and vegetable consumption on IVF outcomes: a review and presentation of original data. Reproductive Biology and Endocrinology , v. 13, p. 134-134, 2015.
CALTON, EMILY K. ; KEANE, KEVIN N. ; NEWSHOLME, Philip ; SOARES, MARIO J. . The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies. Plos One , v. 10, p. e0141770-71, 2015.
KEANE, KEVIN ; HINCHLIFFE, PETER ; NAMDAR, NAVID ; CONCEICAO, JASON ; NEWSHOLME, Philip ; YOVICH, JOHN . Novel dehydroepiandrosterone troche supplementation improves the serum androgen profile of women undergoing in vitro fertilization. Drug Design, Development and Therapy , v. 9, p. 5569-78, 2015.
MCEVOY, BERNADETTE ; SUMAYAO, RODOLFO ; SLATTERY, CRAIG ; MCMORROW, TARA ; NEWSHOLME, Philip . Cystine accumulation attenuates insulin release from the pancreatic β-cell due to elevated oxidative stress and decreased ATP levels. Journal of Physiology (London. Print) , v. 593, p. 5167-5182, 2015.
VISWESWARAN, MALINI ; POHL, SEBASTIAN ; ARFUSO, FRANK ; NEWSHOLME, Philip ; DILLEY, RODNEY ; PERVAIZ, SHAZIB ; DHARMARAJAN, ARUN . Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt. International Journal of Biochemistry & Cell Biology , v. 68, p. 139-147, 2015.
CALTON, E. K. ; PATHAK, K. ; SOARES, M. J. ; ALFONSO, H. ; KEANE, K. N. ; NEWSHOLME, P. ; CUMMINGS, N. K. ; CHAN SHE PING-DELFOS, W. ; HAMIDI, A. . Vitamin D status and insulin sensitivity are novel predictors of resting metabolic rate: a cross-sectional analysis in Australian adults. European Journal of Nutrition (Print) , v. x, p. xxx-xxx, 2015.
KEANE, KEVIN NOEL ; CRUZAT, VINICIUS FERNANDES ; CARLESSI, RODRIGO ; DE BITTENCOURT, PAULO IVO HOMEM ; NEWSHOLME, Philip . Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β -Cell Dysfunction. Oxidative Medicine and Cellular Longevity (Print) , v. 2015, p. 1-15, 2015.
HOMEM DE BITTENCOURT, PAULO IVO ; NEWSHOLME, Philip . You, your children, your grandchildren, and their inflammatory responses are what you eat. Current Opinion in Clinical Nutrition and Metabolic Care , v. 18, p. 325-327, 2015.
SIDARALA, VAIBHAV ; VELUTHAKAL, RAJAKRISHNAN ; SYEDA, KHADIJA ; VLAAR, CORNELIS ; NEWSHOLME, Philip ; KOWLURU, ANJANEYULU . Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1). Biochemical Pharmacology , v. 95, p. 301-310, 2015.
KRAUSE, MAURICIO ; BOCK, PATRICIA MARTINS ; TAKAHASHI, HILTON KENJI ; HOMEM DE BITTENCOURT, PAULO IVO ; NEWSHOLME, Philip . The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes. Clinical Science (1979) , v. 128, p. 789-803, 2015.
KRAUSE, MAURICIO ; HECK, THIAGO GOMES ; BITTENCOURT, ALINE ; SCOMAZZON, SOFIA PIZZATO ; NEWSHOLME, Philip ; CURI, RUI ; HOMEM DE BITTENCOURT, PAULO IVO . The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation-Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management. Mediators of Inflammation (Print) , v. 2015, p. 1-12, 2015.
VISWESWARAN, MALINI ; SCHIEFER, LUCA ; ARFUSO, FRANK ; DILLEY, RODNEY J. ; NEWSHOLME, Philip ; DHARMARAJAN, ARUN . Wnt Antagonist Secreted Frizzled-Related Protein 4 Upregulates Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells. Plos One , v. 10, p. e0118005-3, 2015.
KEANE, KEVIN ; CALTON, EMILY ; CRUZAT, VINICIUS ; SOARES, MARIO ; NEWSHOLME, Philip . The Impact of Cryopreservation on Human Peripheral Blood Leukocyte Bioenergetics.. Clinical Science (1979) , v. 128, p. 723-733, 2015.
CRUZAT, V. F. ; KEANE, K. N. ; SCHEINPFLUG, A. L. ; CORDEIRO, R. ; SOARES, M. ; NEWSHOLME, P. . Alanyl-Glutamine improves pancreatic -cell function following ex vivo inflammatory challenge. Journal of Endocrinology , v. 224, p. 261-271, 2014.
CRUZAT, VINICIUS ; KRAUSE, MAURÍCIO ; NEWSHOLME, Philip . Amino acid supplementation and impact on immune function in the context of exercise. Journal of the International Society of Sports Nutrition , v. 11, p. 61-61, 2014.
SCHIEFER, L ; VISWESWARAN, M ; PERUMAL, V ; ARFUSO, F ; GROTH, D ; Newsholme, P ; WARRIER, S ; DHARMARAJAN, A . Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiforme. Cancer Gene Therapy , v. 21, p. 297-303, 2014.
ELAHY, M. ; BAINDUR-HUDSON, S. ; NEWSHOLME, P. ; DASS, C. . Mechanisms of PEDF mediated protection against ROS damage in diabetic retinopathy and neuropathy. Journal of Endocrinology , v. 222, p. 129-139, 2014.
NEWSHOLME, Philip ; DE BITTENCOURT, PAULO I. HOMEM . The fat cell senescence hypothesis. Current Opinion in Clinical Nutrition and Metabolic Care , v. 17, p. 1-11, 2014.
NEWSHOLME, P. ; CRUZAT, V. ; ARFUSO, F. ; KEANE, K. N. . Nutrient regulation of insulin secretion and action. Journal of Endocrinology , v. 221, p. 105-120, 2014.
MULLOOLY, NIAMH ; VERNON, WENDY ; SMITH, DAVID M. ; NEWSHOLME, Philip . Elevated levels of branched-chain amino acids have little effect on pancreatic islet cells, but -arginine impairs function through activation of the endoplasmic reticulum stress response. Experimental Physiology (Print) , v. 99, p. 538-551, 2014.
KRAUSE, MAURICIO ; KEANE, KEVIN ; RODRIGUES-KRAUSE, JOSIANNE ; CROGNALE, DOMENICO ; EGAN, BRENDAN ; DE VITO, GIUSEPPE ; MURPHY, COLIN ; NEWSHOLME, Philip . Elevated levels of Extracellular Heat Shock Protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro. Clinical Science (1979) , v. 126, p. 739-752, 2013.
KRAUSE, MAURICIO ; RODRIGUES-KRAUSE, JOSIANNE ; O?HAGAN, CIARA ; MEDLOW, PAUL ; DAVISON, GARETH ; SUSTA, DAVIDE ; BOREHAM, COLIN ; NEWSHOLME, Philip ; O?DONNELL, MARK ; MURPHY, COLIN ; VITO, GIUSEPPE . The effects of aerobic exercise training at two different intensities in obesity and type 2 diabetes: implications for oxidative stress, low-grade inflammation and nitric oxide production. European Journal of Applied Physiology (Print) , v. 114, p. 251-260, 2013.
SUMAYAO, RODOLFO ; MCEVOY, BERNADETTE ; MARTIN-MARTIN, NATALIA ; MCMORROW, TARA ; NEWSHOLME, Philip . Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line. Experimental Physiology (Print) , v. 98, p. 1505-1517, 2013.
ALVAREZ'DE'EULATE, EVA ; O'SULLIVAN, SHANE ; FLETCHER, SHARON ; NEWSHOLME, Philip ; ARRIGAN, DAMIEN W. M. . Ion-Transfer Electrochemistry of Rat Amylin at the Water-Organogel Microinterface Array and Its Selective Detection in a Protein Mixture. Chemistry - an Asian Journal (Print) , v. 8, p. 2096-2101, 2013.
GAUDEL, C. ; NONGONIERMA, A. B. ; MAHER, S. ; FLYNN, S. ; KRAUSE, M. ; MURRAY, B. A. ; KELLY, P. M. ; BAIRD, A. W. ; FITZGERALD, R. J. ; NEWSHOLME, P. . A Whey Protein Hydrolysate Promotes Insulinotropic Activity in a Clonal Pancreatic -Cell Line and Enhances Glycemic Function in ob/ob Mice. The Journal of Nutrition (Print) , v. 143, p. 1109-1114, 2013.
FERGUSON, LYNETTE R. ; NEWSHOLME, Philip . Editorial. Current Opinion in Clinical Nutrition and Metabolic Care , v. 16, p. 375-375, 2013.
HATANAKA, ELAINE ; DERMARGOS, ALEXANDRE ; HIRATA, APARECIDA EMIKO ; VINOLO, MARCO AURÉLIO RAMIREZ ; CARPINELLI, ANGELO RAFAEL ; NEWSHOLME, Philip ; ARMELIN, HUGO AGUIRRE ; CURI, RUI . Oleic, Linoleic and Linolenic Acids Increase ROS Production by Fibroblasts via NADPH Oxidase Activation. Plos One , v. 8, p. e58626, 2013.
SALVUCCI, MANUELA ; NEUFELD, ZOLTAN ; NEWSHOLME, Philip . Mathematical Model of Metabolism and Electrophysiology of Amino Acid and Glucose Stimulated Insulin Secretion: In Vitro Validation Using a β-Cell Line. Plos One , v. 8, p. e52611, 2013.
BORTOLON, JOSÉ RICARDO ; SILVA JUNIOR, ANTONIO JOSÉ DE ALMEIDA ; MURATA, GILSON MASAHIRO ; NEWSHOLME, Philip ; CURI, RUI ; PITHON-CURI, TANIA CRISTINA ; HATANAKA, ELAINE . Persistence of Inflammatory Response to Intense Exercise in Diabetic Rats. Experimental Diabetes Research (Print) , v. 2012, p. 1-8, 2012.
Newsholme, P ; KRAUSE, MAURÍCIO . Nutritional regulation of insulin secretion: implications for diabetes.. The Clinical Biochemist Reviews , v. 33, p. 35-47, 2012.
DA SILVA KRAUSE, M. ; BITTENCOURT, A. ; HOMEM DE BITTENCOURT, P. I. ; MCCLENAGHAN, N. H. ; FLATT, P. R. ; MURPHY, C. ; NEWSHOLME, P. . Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic -cell line and mouse islets. Journal of Endocrinology , v. 214, p. 301-311, 2012.
KRAUSE, MAURICIO ; RODRIGUES-KRAUSE, JOSIANNE ; O'HAGAN, CIARA ; DE VITO, GIUSEPPE ; BOREHAM, COLIN ; SUSTA, DAVIDE ; NEWSHOLME, Philip ; MURPHY, COLIN . Differential Nitric Oxide levels in the blood and skeletal muscle of Type 2 diabetic subjects may be consequence of adiposity: a preliminary study. Metabolism, Clinical and Experimental (Print) , v. 01, p. 01-02, 2012.
NEWSHOLME, P. ; REBELATO, E. ; ABDULKADER, F. ; KRAUSE, M. ; CARPINELLI, A. ; CURI, R. . Reactive oxygen and nitrogen species generation, antioxidant defenses, and -cell function: a critical role for amino acids. Journal of Endocrinology , v. 214, p. 11-20, 2012.
FELIPE, E.T. ; MAESTRI, J.S. ; KANUNFRE, C.C. ; CURI, R. ; NEWSHOLME, P. ; CARPINELLI, A.R. ; OLIVEIRA-EMILIO, H.R. . Cytotoxicity and cytoprotective effects of citrus flavonoids on insulin-secreting cells BRIN-BD11: beneficial synergic effects. Natural Product Research (Print) , v. 27, p. 1-4, 2012.
RODRIGUES-KRAUSE, JOSIANNE ; KRAUSE, MAURICIO ; O?HAGAN, C. ; VITO, GIUSEPPE ; BOREHAM, COLIN ; MURPHY, COLIN ; NEWSHOLME, Philip ; COLLERAN, GERARD . Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?. Cell Stress & Chaperones (Print) , v. 17, p. 293-302, 2012.
TAKAHASHI, HILTON KENJI ; CAMBIAGHI, TAVANE DAVID ; LUCHESSI, AUGUSTO DUCATI ; HIRABARA, SANDRO MASSAO ; VINOLO, MARCO AURELIO RAMIREZ ; NEWSHOLME, Philip ; CURI, RUI . Activation of survival and apoptotic signaling pathways in lymphocytes exposed to palmitic acid. Journal of Cellular Physiology (Print) , v. 227, p. 339-350, 2012.
MAGDALON, JULIANA ; HATANAKA, ELAINE ; ROMANATTO, TALITA ; RODRIGUES, HOSANA G ; KUWABARA, WILSON MT ; SCAIFE, CAITRIONA ; NEWSHOLME, Philip ; CURI, RUI . A proteomic analysis of the functional effects of fatty acids in NIH 3T3 fibroblasts. Lipids in Health and Disease , v. 10, p. 218-218, 2011.
KRAUSE, M. S. ; MCCLENAGHAN, N. H. ; FLATT, P. R. ; HOMEM DE BITTENCOURT, P. I. ; MURPHY, C. ; NEWSHOLME, P. . L-Arginine is essential for pancreatic -cell functional integrity, metabolism and defense from inflammatory challenge. Journal of Endocrinology , v. 211, p. 87-97, 2011.
NEWSHOLME, P. ; KRAUSE, M. ; NEWSHOLME, E. A. ; STEAR, S. J. ; BURKE, L. M. ; CASTELL, L. M. . BJSM reviews: A to Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--Part 18. British Journal of Sports Medicine , v. 45, p. 230-232, 2011.
SPÉGEL, PETER ; MALMGREN, SIRI ; SHAROYKO, VLADIMIR V. ; NEWSHOLME, Philip ; KOECK, THOMAS ; MULDER, HINDRIK . Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines. Biochemical Journal (London. 1984) , v. 435, p. 277-284, 2011.
NEWSHOLME, Philip ; ABDULKADER, F. ; REBELATO, E. ; ROMANATTO, T. ; PINHEIRO, C. H. ; VITZEL, K. F. ; SILVA, E. P. ; BAZOTTE, R. B. ; Procópio, J ; CURI, RUI ; Gorjão, R ; PITHON-CURI, TANIA CRISTINA . Amino acids and diabetes: implications for endocrine, metabolic and immune function. Frontiers in Bioscience , v. 16, p. 315-339, 2011.
KEANE, DEIRDRE C. ; TAKAHASHI, HILTON K. ; DHAYAL, SHALINEE ; MORGAN, NOEL G. ; CURI, RUI ; NEWSHOLME, Philip . Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line. Clinical Science (1979) , v. 120, p. 195-206, 2011.
MASTERS, SETH L ; DUNNE, AISLING ; SUBRAMANIAN, SHOBA L ; HULL, REBECCA L ; TANNAHILL, GILLIAN M ; SHARP, FIONA A ; BECKER, CHRISTINE ; FRANCHI, LUIGI ; YOSHIHARA, EIJI ; CHEN, ZHE ; MULLOOLY, NIAMH ; MIELKE, LISA A ; HARRIS, JAMES ; COLL, REBECCA C ; MILLS, KINGSTON H G ; MOK, K HUN ; NEWSHOLME, Philip ; NUÑEZ, GABRIEL ; YODOI, JUNJI ; KAHN, STEVEN E ; LAVELLE, ED C ; O'NEILL, LUKE A J . Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nature Immunology (Print) , v. 11, p. 897-904, 2010.
WOLF, G. ; AUMANN, N. ; MICHALSKA, M. ; BAST, A. ; SONNEMANN, J. ; BECK, J. F. ; LENDECKEL, U. ; NEWSHOLME, P. ; WALTHER, R. . Peroxiredoxin III protects pancreatic cells from apoptosis. Journal of Endocrinology , v. 207, p. 163-175, 2010.
MICHALSKA, MARTA ; WOLF, GABRIELE ; WALTHER, REINHARD ; NEWSHOLME, Philip . Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H O -induced mouse islet or clonal pancreatic β-cell dysfunction. Bioscience Reports , v. 30, p. 445-453, 2010.
NEWSHOLME, Philip ; HOMEM DE BITTENCOURT, PAULO I. ; O' HAGAN, CIARA ; DE VITO, GIUSEPPE ; MURPHY, COLIN ; KRAUSE, MAURICIO S. . Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide. Clinical Science (1979) , v. 118, p. 341-349, 2009.
NEWSHOLME, P. ; MORGAN, D. ; REBELATO, E. ; OLIVEIRA-EMILIO, H. C. ; PROCOPIO, J. ; CURI, R. ; CARPINELLI, A. . Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia (Berlin) , v. 52, p. 2489-2498, 2009.
KIELY, A. ; ROBINSON, A. ; MCCLENAGHAN, N. H ; FLATT, P. R ; NEWSHOLME, P. . Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 -cell insulin secretion and signal transduction. Journal of Endocrinology , v. 202, p. 365-373, 2009.
BENDER, KATRIN ; MAECHLER, PIERRE ; MCCLENAGHAN, NEVILLE H. ; FLATT, PETER R. ; NEWSHOLME, Philip . Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism. Clinical Science (1979) , v. 117, p. 321-330, 2009.
VINOLO, MARCO A. R. ; HATANAKA, ELAINE ; LAMBERTUCCI, RAFAEL H. ; NEWSHOLME, Philip ; CURI, RUI . Effects of short chain fatty acids on effector mechanisms of neutrophils. Cell Biochemistry and Function , v. 27, p. 48-55, 2009.
MCCLENAGHAN, NEVILLE H. ; SCULLION, SIOBHAN M. ; MION, BRIAN ; HEWAGE, CHANDRALAL ; MALTHOUSE, J. PAUL G. ; FLATT, PETER R. ; NEWSHOLME, Philip ; BRENNAN, LORRAINE . Prolonged L-alanine exposure induces changes in metabolism, Ca handling and desensitization of insulin secretion in clonal pancreatic β-cells. Clinical Science (1979) , v. 116, p. 341-351, 2009.
KEANE, DEIRDRE ; NEWSHOLME, Philip . Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic β-cells. Biochemical Society Transactions , v. 36, p. 955-958, 2008.
O?GORMAN, DONAL J. ; YOUSIF, OBADA ; DIXON, GORDON ; MCQUAID, SIOBHAN ; MURPHY, ELAINE ; RAHMAN, YOUSIF ; GASPARRO, DECLAN ; PACINI, GIOVANNI ; NEWSHOLME, Philip ; NOLAN, JOHN J. . In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: A distinct sub-phenotype. Diabetes Research and Clinical Practice (Print) , v. 80, p. 365-370, 2008.
NEWSHOLME, P. ; BENDER, K. ; KIELY, A. ; BRENNAN, L. . Amino acid metabolism, insulin secretion and diabetes. Biochemical Society Transactions , v. 35, p. 1180-1186, 2007.
KIELY, A. ; MCCLENAGHAN, N. H ; FLATT, P. R ; NEWSHOLME, P. . Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic -cell line. Journal of Endocrinology , v. 195, p. 113-123, 2007.
NEWSHOLME, P. ; HABER, E. P. ; HIRABARA, S. M. ; REBELATO, E. L. O. ; PROCOPIO, J. ; MORGAN, D. ; OLIVEIRA-EMILIO, H. C. ; CARPINELLI, A. R. ; CURI, R. . Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. Journal of Physiology (London. Print) , v. 583, p. 9-24, 2007.
CALDER, PHILIP C ; DIMITRIADIS, GEORGE ; NEWSHOLME, Philip . Glucose metabolism in lymphoid and inflammatory cells and tissues. Current Opinion in Clinical Nutrition and Metabolic Care , v. 10, p. 531-540, 2007.
MORGAN, D. ; OLIVEIRA-EMILIO, H. R. ; KEANE, D. ; HIRATA, A. E. ; SANTOS DA ROCHA, M. ; BORDIN, S. ; CURI, R. ; NEWSHOLME, P. ; CARPINELLI, A. R. . Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line. Diabetologia (Berlin) , v. 50, p. 359-369, 2007.
NEWSHOLME, Philip ; KEANE, DEIRDRE ; WELTERS, HANNAH J. ; MORGAN, NOEL G. . Life and death decisions of the pancreatic β-cell: the role of fatty acids. Clinical Science (1979) , v. 112, p. 27-42, 2007.
CURI, RUI ; NEWSHOLME, P. ; PROCOPIO, J. ; LAGRANHA, C. ; Gorjão, R ; PITHON-CURI, TANIA CRISTINA . Glutamine, gene expression, and cell function. Frontiers in Bioscience (Print) , v. 12, p. 344-357, 2007.
BRENNAN, LORRAINE ; HEWAGE, CHANDRALAL ; MALTHOUSE, J. P. G. ; McClenaghan, Neville H. ; FLATT, PETER R. ; NEWSHOLME, Philip . Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism. The FEBS Journal (Print) , v. 273, p. 5160-5168, 2006.
BENDER, K. ; NEWSHOLME, P. ; BRENNAN, L. ; MAECHLER, P. . The importance of redox shuttles to pancreatic β-cell energy metabolism and function. Biochemical Society Transactions , v. 34, p. 811-814, 2006.
CORLESS, M. ; KIELY, A. ; MCCLENAGHAN, N. ; FLATT, P. ; NEWSHOLME, Philip . Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell linek. Journal of Endocrinology , v. 190, p. 719-727, 2006.
GORJÃO, RENATA ; VERLENGIA, ROZANGELA ; LIMA, THAIS MARTINS DE ; SORIANO, FRANCISCO GARCIA ; BOAVENTURA, MARIA FERNANDA CURY ; KANUNFRE, CARLA CHRISTINE ; PERES, CARMEM MALDONADO ; SAMPAIO, SANDRA CONCUZZO ; OTTON, ROSEMARI ; FOLADOR, ALESSANDRA ; MARTINS, EDGAIR FERNANDES ; CURI, TANIA CRISTINA PITHON ; PORTIOLLI, ÉRICA PAULA ; NEWSHOLME, Philip ; CURI, RUI . Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function. Clinical Nutrition (Edinburgh) , v. 25, p. 923-938, 2006.
PATTERSON, S. ; FLATT, P. ; BRENNAN, LORRAINE ; NEWSHOLME, Philip ; MCCLENAGHAN, N. . Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion. Journal of Endocrinology , v. 189, p. 301-310, 2006.
CURY-BOAVENTURA, MARIA F. ; GORJÃO, RENATA ; DE LIMA, THAÍS MARTINS ; NEWSHOLME, Philip ; CURI, RUI . Comparative toxicity of oleic and linoleic acid on human lymphocytes. Life Sciences (1973) , v. 78, p. 1448-1456, 2006.
CUNNINGHAM, GRAINNE A. ; MCCLENAGHAN, NEVILLE H. ; FLATT, PETER R. ; NEWSHOLME, Philip . L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis. Clinical Science (1979) , v. 109, p. 447-455, 2005.
CURI, R. ; LAGRANHA, C.J. ; DOI, S.Q. ; SELLITTI, D.F. ; PROCOPIO, J. ; PITHON-CURI, T.C. ; CORLESS, M. ; NEWSHOLME, P. . Molecular mechanisms of glutamine action. Journal of Cellular Physiology (Print) , v. 204, p. 392-401, 2005.
NEWSHOLME, Philip ; BRENNAN, LORRAINE ; RUBI, BLANCA ; MAECHLER, PIERRE . New insights into amino acid metabolism, β-cell function and diabetes. Clinical Science (1979) , v. 108, p. 185-194, 2005.
VERLENGIA, ROZANGELA ; GORJÃO, RENATA ; KANUNFRE, CARLA CRISTINE ; BORDIN, SILVANA ; LIMA, THAIS MARTINS ; MARTINS, EDGAIR FERNANDES ; NEWSHOLME, Philip ; CURI, RUI . Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells. Lipids , v. 39, p. 857-864, 2004.
MARTINS, EDGAIR FERNANDES ; MIYASAKA, C. K. ; NEWSHOLME, Philip ; CURI, RUI ; CARPINELLI, ANGELO RAFAEL . Changes of fatty acid composition in incubated rat pancreatic islets. Diabetes & Metabolism , v. 30, p. 21-27, 2004.
NEWSHOLME, Philip ; ANGELOS, K. L. ; WALSH, D. A. . High and intermediate affinity calmodulin binding domains of the alpha and beta subunits of phosphorylase kinase and their potential role in phosphorylation-dependent activation of the holoenzyme.. The Journal of Biological Chemistry (Print) , v. 267, p. 810-818, 1992.
WALSH, D. A. ; NEWSHOLME, P. ; CAWLEY, K. C. ; van PATTEN, S. M. ; ANGELOS, K. L. . Motifs of protein phosphorylation and mechanisms of reversible covalent regulation. Physiological Reviews , v. 71, p. 285-304, 1991.
ALMEIDA, A. F. ; CURI, RUI ; NEWSHOLME, Philip ; NEWSHOLME, E. A. . Maximal activities of key enzymes of glutaminolysis, glycolysis, Krebs cycle and pentose-phosphate pathway of several tissues in mature and aged rats. International Journal of Biochemistry , v. 21, p. 937-940, 1989.
CURI, R ; Newsholme, P ; NEWSHOLME, E A . Metabolism of pyruvate by isolated rat mesenteric lymphocytes, lymphocyte mitochondria and isolated mouse macrophages. Biochemical Journal (London. 1984) , v. 250, p. 383-388, 1988.
Newsholme, P ; GORDON, S ; NEWSHOLME, E A . Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages. Biochemical Journal (London. 1984) , v. 242, p. 631-636, 1987.
CURI, R. ; NEWSHOLME, P. ; NEWSHOLME, E.A. . Intracellular distribution of some enzymes of the glutamine utilisation pathway in rat lymphocytes. Biochemical and Biophysical Research Communications (Print) , v. 138, p. 318-322, 1986.
Newsholme, P ; CURI, R ; GORDON, S ; NEWSHOLME, E A . Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochemical Journal (London. 1984) , v. 239, p. 121-125, 1986.
KEANE, KEVIN ; NEWSHOLME, Philip . Vitamins & Hormones. 1. ed. Filadélfia, USA: Elsevier, 2014. v. 1. 33p .
NEWSHOLME, Philip ; Gaudel, Celine ; Krause, Maurico . Mitochondria and Diabetes. An Intriguing Pathogenetic Role. Advances in Experimental Medicine and Biology. 1ed.New York: Springer Netherlands, 2012, v. 942, p. 235-247.
NEWSHOLME, Philip ; Gaudel, Celine ; McClenaghan, Neville H. . Nutrient Regulation of Insulin Secretion and β-Cell Functional Integrity. Advances in Experimental Medicine and Biology. 1ed.New York: Springer Netherlands, 2010, v. 654, p. 91-114.
Haber, Esther P. ; Procópio, Joaquim ; Carvalho, Carla R.O. ; Carpinelli, Angelo R. ; NEWSHOLME, Philip ; CURI, RUI . New Insights into Fatty Acid Modulation of Pancreatic β Cell Function. International Review of Cytology. 1ed.New York: Elsevier, 2006, v. 248, p. 1-41.

Histórico profissional

Endereço profissional

Curtin University of Technology, Faculty of Health Sciences. , Faculty of Health Sciences and CHIRI GPOBoxU1987, WA, 6845 - Perth, - Austrália, Telefone: (618) 92667425, URL da Homepage:

Experiência profissional

1993 - 2011

University College Dublin

Vínculo: , Enquadramento Funcional: Professor titular, Carga horária: 40, Regime: Dedicação exclusiva.

Atividades

10/1993
Ensino, Medicine, Nível: Graduação,Disciplinas ministradas, Biochemistry for the Medical Sciences

2011 - Atual

Curtin University of Technology

Vínculo: Servidor Público, Enquadramento Funcional: Professor Titular, Diretor do Instituto, Carga horária: 40, Regime: Dedicação exclusiva.