Igor dos Santos Cestari

Bacharelado em Ciencias biologicas (UFPE) e mestrado e doutarado em biologia celular e molecular pelo Instituto Oswaldo Cruz. Atuou como posdoutor no Seattle Biomedical Research Center (USA, laboratorio do Ken Stuart). Atualmente e professor associado da McGill University, investigando mecanismo de evasao imune pelos protozoarios trypanosomatideos, com enfase a variacao antigenica, e desenvolvimento de drogas e vacinas para a doenca de Chagas.

Informações coletadas do Lattes em 17/07/2025

Acadêmico

Formação acadêmica

Doutorado em Biologia Celular e Molecular

2006 - 2010

Fundação Oswaldo Cruz
Título: Caracterizacao dos Mecanismos de ativacao e resistencia a lise mediada pelo complemento por Trypanosoma cruzi e oenvolvimento de microvesiculas de monocitos na evasao imune
Orientador: em London Metropolitan University ( Jameel M. Inal)
com Marcel Ivan Ramirez Araya. Bolsista do(a): Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Brasil.

Mestrado em Biologia Celular e Molecular

2004 - 2006

Fundação Oswaldo Cruz
Título: Trypanosoma cruzi e o sistema complemento: Mecanismos de ativação e caracterização funcional do gene CRIT em cepas de classe I e II, Ano de Obtenção: 2006
Marcel Ivan Ramirez Araya.Bolsista do(a): Fundação Oswaldo Cruz, FIOCRUZ, Brasil.

Graduação em Bacharelado em Ciências Biológicas

2000 - 2003

Universidade Federal de Pernambuco
Título: Mecanismos de Ativação do Sistema Complemento por Tripanossomatídeos
Orientador: Dr Marcel Ivan Ramirez Araya
Bolsista do(a): Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco, FACEPE, Brasil.

Pós-doutorado

2010 - 2018

Pós-Doutorado. , Center for Infectious Disease Research, CIDR, Estados Unidos. , Bolsista do(a): National Institutes of Health, NIH, Estados Unidos.

Formação complementar

2008 - 2008

Scientific trainning in Biochemistry. (Carga horária: 24h). , MRC Immunochemistry Unit, University of Oxford, MRC-OXFORD, Inglaterra.

2007 - 2007

Scientific trainning in Biochemistry. (Carga horária: 960h). , Welcome trust for molecular parasitology - University of Glasgow, WTMP, Escócia.

2005 - 2005

Sensibilização e Informação Em Biosegurança. (Carga horária: 40h). , Fundação Oswaldo Cruz, FIOCRUZ, Brasil.

2003 - 2003

I Curso de Biologia Molecular da Interação Parasit. (Carga horária: 80h). , Centro de Pesquisas Aggeu Magalhães, CPQAM-FIOCRUZ, Brasil.

2003 - 2003

Curso de Terapia Gênica: Teoria e Prática. (Carga horária: 80h). , Universidade Federal de São Paulo, UNIFESP, Brasil.

2001 - 2001

Curso Teórico Em Pós Genômica de Parasitas. (Carga horária: 50h). , Universidade Federal de Pernambuco, UFPE, Brasil.

2001 - 2001

I Workshop Em Proteômica Parasitária. , Universidade Federal de Pernambuco, UFPE, Brasil.

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Espanhol

Compreende Bem, Fala Bem, Lê Bem, Escreve Pouco.

Português

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Francês

Compreende Razoavelmente, Fala Razoavelmente, Lê Razoavelmente, Escreve Razoavelmente.

Áreas de atuação

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.

Grande área: Ciências Biológicas / Área: Parasitologia.

Grande área: Ciências Biológicas / Área: Bioquímica.

Grande área: Ciências Biológicas / Área: Imunologia.

Grande área: Ciências Biológicas / Área: Genética.

Participação em eventos

13th International Congress of Protistology/25th Annual Meeting of the Brazilian Society of Protozoology/26th Annual Meeting on Basic Research in Chagas Disase. Trypanosoma cruzi induce blood cells to release microvesicles that inhibit complement lysis and promote cell invasion. 2009. (Congresso).

BSP Spring and Malaria Meeting. MECHANISM OF COMPLEMENT LECTIN PATHWAY ACTIVATION AND RESISTANCE BY Trypanosoma cruzi. 2008. (Congresso).

ICOPA XI - International Congress in Parasitology. MECHANISM OF COMPLEMENT LECTIN PATHWAY ACTIVATION BY Trypanosoma cruzi. 2006. (Congresso).

XXI Meeting of SBPz, Annual meeting on basic research on Chagas´disese. International Congress of Chagas´disease. 2005. (Congresso).

XX Meeting of the SBPZ. A new annotation of trypanosomatids hypothetical proteins searching motifs and domains as functional patterns. 2004. (Congresso).

55 Reunião Anual da SBPC. Mecanismo de Ação do Sistema Complemento na defesa Imunológica contra Tripanossomatideos. 2003. (Congresso).

Disease Research Symposium 2003.Overexpressed CRP and CRIT genes confers resistence to complement mediated lysis in epimastigotes forms of T. cruzi. 2003. (Simpósio).

Jornada Norte/Nordeste de Inicação científica da FIOCRUZ. Diferentes Mecanismos de Ativação do Sistema Complemento em Tripanossomatídeos. 2003. (Congresso).

Seminário do Departamento de Imunologia, CPqAM-Fiocruz.Mecanismo de Ativação do Sistema Complemento por Trypanossomatídeos. 2003. (Seminário).

Tropical Disease Research Symposium.Prot-OGIM: A novel software to identify motifs in orphan genes from protozoan genomes program. 2003. (Simpósio).

XXX Annual Meeting on Basic Reseach in Chagas Disease. Prot-OGIM: A novel software to identify motifs in orphan genes from protozoan genomes program. 2003. (Congresso).

XXX Annual Meetin on Basic Research in Chagas Disease. Early Mechanism of complement-mediated lysis are diferent among T. cruzi lineage. 2003. (Congresso).

Congresso de Iniciação Científica. Mecanismo de ativação do Sistema Complemento porTripanossomatídeos. 2002. (Congresso).

IV Bienal Fiocruz. Entendendo os mecanismos de resistência a lise pelo complemento em tripanossomatídeos. 2002. (Congresso).

XXIX Annual Meeting on Basic Research in Chagas Disease. Dissecting the Mecanism of Resistence to Complement-Mediated Lysis on Trypanosomatids. 2002. (Congresso).

Produções bibliográficas

DUTRA, PATRÍCIA MARIA LOURENÇO ; RODRIGUES, LUCIANA SILVA ; PINHEIRO, ROBERTA OLMO ; PEREIRA MANFRO, WÂNIA FERRAZ ; Cestari, Igor ; DA-SILVA, SÍLVIA AMARAL GONÇALVES . Editorial: Cellular immune response and escape mechanisms of intracellular parasites. Frontiers in Immunology , v. 15, p. 1-2, 2024.
TOURAY, ABDOULIE ; STERNLIEB, TAMARA ; ISEBE, TONY ; Cestari, Igor . Identifying Antigenic Switching by Clonal Cell Barcoding and Nanopore Sequencing in Trypanosoma brucei. BIO-PROTOCOL , v. 13, p. 1-12, 2023.
TOURAY, ABDOULIE O ; RAJESH, RISHI ; ISEBE, TONY ; STERNLIEB, TAMARA ; LOOCK, MIRA ; KUTOVA, OKSANA ; Cestari, Igor . PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes. eLife , v. 12, p. 1-12, 2023.
HESLOP, RHIANNON ; GAO, MENGJIN ; BRITO LIRA, ANDRESSA ; STERNLIEB, TAMARA ; LOOCK, MIRA ; SANGHI, SAHIL RAO ; Cestari, Igor . Genome-Wide Libraries for Protozoan Pathogen Drug Target Screening Using Yeast Surface Display. ACS Infectious Diseases , v. 9, p. 1078-1091, 2023.
LOOCK, M. ; ANTUNES, L. B. ; HESLOP, R. ; LIRA, A. B. ; AFONSO, A. ; Cestari, I. . High-Efficiency Transformation and Expression of Genomic Libraries in Yeast. Methods And Protocols , v. 6, p. 1, 2023.
STERNLIEB, TAMARA ; LOOCK, MIRA ; GAO, MENGJIN ; Cestari, Igor . Efficient Generation of Genome-wide Libraries for Protein-ligand Screens Using Gibson Assembly. BIO-PROTOCOL , v. 12, p. 1-12, 2022.
ALTAMURA, FERNANDO ; RAJESH, RISHI ; CATTA-PRETA, CAROLINA M. C. ; MORETTI, NILMAR S. ; Cestari, Igor . The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets. DRUG DEVELOPMENT RESEARCH , v. Apr, p. 225, 2022.
MARAN, SUELLEN RODRIGUES ; FLECK, KRISTA ; MONTEIRO-TELES, NATÁLIA MELQUIE ; ISEBE, TONY ; WALRAD, PEGINE ; JEFFERS, VICTORIA ; Cestari, Igor ; VASCONCELOS, ELTON J.R. ; MORETTI, NILMAR . Protein acetylation in the critical biological processes in protozoan parasites. TRENDS IN PARASITOLOGY , v. 37, p. 815-830, 2021.
MARIN, PAULA ANDREA ; OBONAGA, RICARDO ; PAVANI, RAPHAEL SOUZA ; DA SILVA, MARCELO SANTOS ; DE ARAUJO, CHRISTIANE BEZERRA ; LIMA, ANDRÉ ARRUDA ; AVILA, CARLA CRISTI ; Cestari, Igor ; MACHADO, CARLOS RENATO ; ELIAS, MARIA CAROLINA . ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY , v. 8, p. 1, 2020.
Cestari, Igor ; STUART, KENNETH . The phosphoinositide regulatory network in Trypanosoma brucei: Implications for cell-wide regulation in eukaryotes. PLoS Neglected Tropical Diseases , v. 14, p. e0008689, 2020.
APHASIZHEVA, INNA ; ALFONZO, JUAN ; CARNES, JASON ; Cestari, Igor ; CRUZ-REYES, JORGE ; GÖRINGER, H. ULRICH ; HAJDUK, STEPHEN ; LUKE?, JULIUS ; MADISON-ANTENUCCI, SUSAN ; MASLOV, DMITRI A. ; MCDERMOTT, SUZANNE M. ; OCHSENREITER, TORSTEN ; READ, LAURIE K. ; SALAVATI, REZA ; SCHNAUFER, ACHIM ; SCHNEIDER, ANDRÉ ; SIMPSON, LARRY ; STUART, KENNETH ; YURCHENKO, VYACHESLAV ; ZHOU, Z. HONG . Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes. TRENDS IN PARASITOLOGY , v. 36, p. 337-355, 2020.
Cestari, Igor . Phosphoinositide signaling and regulation in Trypanosoma brucei: Specialized functions in a protozoan pathogen. PLoS Pathogens , v. 16, p. e1008167, 2020.
VIJAYAN, KAMALAKANNAN ; Cestari, Igor ; MAST, FRED D. ; GLENNON, ELIZABETH K.K. ; MCDERMOTT, SUZANNE M. ; KAIN, HEATHER S. ; BROKAW, ALYSSA M. ; AITCHISON, JOHN D. ; STUART, KENNETH ; KAUSHANSKY, ALEXIS . Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry. Iscience , v. 21, p. 603-611, 2019.
Cestari, Igor . Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry. Jove-Journal of Visualized Experiments , v. Jun, p. 1, 2019.
Cestari, Igor ; MCLELAND-WIESER, HILARY ; STUART, KENNETH . Nuclear Phosphatidylinositol 5-Phosphatase Is Essential for Allelic Exclusion of Variant Surface Glycoprotein Genes in Trypanosomes. Molecular And Cellular Biology , v. 39, p. 1, 2019.
Cestari, Igor ; ANUPAMA, ATASHI ; STUART, KENNETH . Inositol polyphosphate multikinase regulation of life stage development. MOLECULAR BIOLOGY OF THE CELL , v. 29, p. 1137-1152, 2018.
Cestari, Igor ; STUART, KEN . Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes. CURRENT GENOMICS , v. 19, p. 1, 2018.
MORETTI, NILMAR SILVIO ; Cestari, Igor ; ANUPAMA, ATASHI ; STUART, KEN ; SCHENKMAN, SERGIO . Comparative Proteomic Analysis of Lysine Acetylation in Trypanosomes. JOURNAL OF PROTEOME RESEARCH , v. 17, p. 374-385, 2018.
Cestari, Igor ; HAAS, PAIGE ; MORETTI, NILMAR SILVIO ; SCHENKMAN, SERGIO ; STUART, KEN . Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites. CELL CHEMICAL BIOLOGY , v. 23, p. 608-617, 2016.
LI, QIONG ; LEIJA, CHRISTOPHER ; RIJO'FERREIRA, FILIPA ; CHEN, JUN ; Cestari, Igor ; STUART, KENNETH ; TU, BENJAMIN P. ; PHILLIPS, MARGARET A. . synthase is essential for viability and infectivity of despite a redundant purine salvage pathway. MOLECULAR MICROBIOLOGY , v. 97, p. 1006-1020, 2015.
Cestari, Igor ; STUART, KEN . Inositol phosphate pathway controls transcription of telomeric expression sites in trypanosomes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , v. 112, p. 1, 2015.
PHAN, ISABELLE Q. H. ; DAVIES, DOUGLAS R. ; MORETTI, NILMAR SILVIO ; SHANMUGAM, DHANASEKARAN ; Cestari, Igor ; ANUPAMA, ATASHI ; FAIRMAN, JAMES W. ; EDWARDS, THOMAS E. ; STUART, KENNETH ; SCHENKMAN, SERGIO ; MYLER, PETER J. . Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures. Acta Crystallographica Section F-Structural Biology Communications , v. 71, p. 615-621, 2015.
CARNES, JASON ; ANUPAMA, ATASHI ; BALMER, OLIVER ; JACKSON, ANDREW ; LEWIS, MICHAEL ; BROWN, ROB ; Cestari, Igor ; DESQUESNES, MARC ; GENDRIN, CLAIRE ; HERTZ-FOWLER, CHRISTIANE ; IMAMURA, HIDEO ; IVENS, ALASDAIR ; KO'ENÝ, LUDě ; LAI, DE-HUA ; MACLEOD, ANNETTE ; MCDERMOTT, SUZANNE M. ; MERRITT, CHRIS ; MONNERAT, SEVERINE ; MOON, WONJONG ; MYLER, PETER . Genome and Phylogenetic Analyses of Trypanosoma evansi Reveal Extensive Similarity to T. brucei and Multiple Independent Origins for Dyskinetoplasty. PLoS Neglected Tropical Diseases , v. 9, p. e3404, 2015.
KALIDAS, SAVITHA ; Cestari, Igor ; MONNERAT, SEVERINE ; LI, QIONG ; REGMI, SANDESH ; HASLE, NICHOLAS ; LABAIED, MEHDI ; PARSONS, MARILYN ; STUART, KENNETH ; PHILLIPS, MARGARET A. . Genetic Validation of Aminoacyl-tRNA Synthetases as Drug Targets in Trypanosoma brucei. EUKARYOTIC CELL , v. 13, p. 504-516, 2014.
Cestari, Igor ; KALIDAS, SAVITHA ; MONNERAT, SEVERINE ; ANUPAMA, ATASHI ; PHILLIPS, MARGARET A. ; STUART, KENNETH . A Multiple Aminoacyl-tRNA Synthetase Complex That Enhances tRNA-Aminoacylation in African Trypanosomes. Molecular And Cellular Biology , v. 33, p. 4872-4888, 2013.
Cestari, Igor ; STUART, KENNETH . Inhibition of Isoleucyl-tRNA Synthetase as a Potential Treatment for Human African Trypanosomiasis. JOURNAL OF BIOLOGICAL CHEMISTRY , v. 288, p. 14256-14263, 2013.
Cestari, Igor ; STUART, KENNETH . A Spectrophotometric Assay for Quantitative Measurement of Aminoacyl-tRNA Synthetase Activity. SLAS Discovery , v. 18, p. 490-497, 2013.
Cestari, Igor ; EVANS-OSSES, INGRID ; SCHLAPBACH, LUREGN J. ; DE MESSIAS-REASON, IARA ; RAMIREZ, MARCEL I. . Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites. MOLECULAR IMMUNOLOGY , v. 53, p. 328-334, 2013.
CESTARI, I. ; Ansa-Addo, E. ; DEOLINDO, P. ; INAL, J. M. ; RAMIREZ, M. I. . Trypanosoma cruzi Immune Evasion Mediated by Host Cell-Derived Microvesicles. JOURNAL OF IMMUNOLOGY , v. 188, p. 1942-1952, 2012.
ANSA-ADDO, E. A. ; LANGE, S. ; STRATTON, D. ; ANTWI-BAFFOUR, S. ; CESTARI, I. ; RAMIREZ, M. I. ; MCCROSSAN, M. V. ; INAL, J. M. . Human Plasma Membrane-Derived Vesicles Halt Proliferation and Induce Differentiation of THP-1 Acute Monocytic Leukemia Cells. JOURNAL OF IMMUNOLOGY , v. 185, p. 5236-5246, 2010.
Cestari, Igor ; RAMIREZ, MARCEL I. . Inefficient Complement System Clearance of Trypanosoma cruzi Metacyclic Trypomastigotes Enables Resistant Strains to Invade Eukaryotic Cells. PLoS One , v. 5, p. e9721, 2010.
CESTARI, I. S. ; KRARUP, A. ; Sim, R.B. ; INAL, Jameel ; RAMIREZ, Marcel Ivan . Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi. MOLECULAR IMMUNOLOGY , v. 47, p. 426-437, 2009.
CESTARI, I. S. ; Evans?Osses, Ingrid ; Freitas, Juliana ; Inal, Jameel ; Ramirez, Marcel . Complement C2 Receptor Inhibitor Trispanning Confers an Increased Ability to Resist Complement?Mediated Lysis in. The Journal of Infectious Diseases , v. 198, p. 1276-1283, 2008.
CESTARI, I. S. ; HAVER, Nicolaas Johannes ; BARBOSA-SILVA, Adriano ; RAMIREZ, Marcel Ivan . PROTOGIM: A novel tool to search domains and motifs in hypothetical proteins of protozoan genomes. Parasitology Research , Short communication, v. 98, n.4, p. 375-377, 2006.
CESTARI, I. S. ; Ansa-Addo, E. ; PATHAK, P. ; RAMIREZ, Marcel Ivan ; INAL, JM . The intracellular Trypanosoma cruzi induces the release from monocytes of plasma membrane-derived microvesicles which protect the parasite from host complement. In: ICW Basel, XXII International Complement Workshop, 2008, Basel. Molecular Immunlogy. Oxford: Elsevier, 2008. v. 45. p. 4041-4282.
INAL, JM ; CESTARI, I. S. ; OSSES, Ingrid Solange Evans ; ARAYA, Marcel Ivan Ramirez . The C2 receptor CRIT protects Trypanosoma cruzi against classical and MBL-directed, but not alternative pathway complement activation. In: Meeting in Complement System, 2007, Switzland. The Journal of Immunology, 2007. v. 178. p. 14-14.
CESTARI, I. S. ; Ansa-Addo, E. ; INAL, JM ; RAMIREZ, Marcel Ivan . Trypanosoma cruzi induce blood cells to release microvesicles that stabilize C3 convertase and promote cell invasion.. In: Centenary of the Discovery of Chagas Disease, 2009, Rio de Janeiro. Centenary of the Discovery of Chagas Disease Abstracts, 2009.
CESTARI, I. S. ; Ansa-Addo, E. ; INAL, JM ; RAMIREZ, Marcel Ivan . Trypanosoma cruzi induce blood cells to release microvesicles that inhibit complement lysis and promote cell invasion.. In: 13th International Congress of Protistology/25th Annual Meeting of the Brazilian Society of Protozoology/26th Annual Meeting on Basic Research in Chagas Disase, 2009, Buzios. Abstracts of 13th International Congress of Protistology, 2009.
CESTARI, I. S. ; INAL, JM ; ARAYA, Marcel Ivan Ramirez . MECHANISM OF COMPLEMENT LECTIN PATHWAY ACTIVATION AND RESISTANCE BY Trypanosoma cruzi. In: BSP Spring and Malaria Meeting, 2008, Newcastle - UK. BSP Spring and Malaria Meeting. Newcastle, 2008. v. x.
CESTARI, I. S. ; OSSES, Ingrid Solange Evans ; HUI, K-M ; INAL, Jameel ; ARAYA, Marcel Ivan Ramirez . Mechanism of Lectin Complement Pathway Activation By Trypanosoma cruzi. In: 11th International Congress of Parasitology ICOPA XI, 2006, Glasgow. 11th International Congress of Parasitology ICOPA XI, 2006.
CESTARI, I. S. . THE ROLE OF THE MANNAN-BINDING LECTIN ACCEPTORS IN THE LECTIN COMPLEMENT PATHWAY ACTIVATION BY. In: XXII Reunião Anual da Sociedade Brasileira de Protozoologia/XXXIII Reunião Anual sobre Pesquisa Básica em Doença de Chagas, 2006, Caxambu-MG. Anais da XXII Reunião Anual da Sociedade Brasileira de Protozoologia/XXXIII Reunião Anual sobre Pesquisa Básica em Doença de Chagas, 2006.
CESTARI, I. S. ; OSSES, Ingrid Solange Evans ; INAL, Jameel ; ARAYA, Marcel Ivan Ramirez . MECHANISM OF COMPLEMENT LECTIN PATHWAY ACTIVATION BY Trypanosoma cruzi. In: ICOPA XI - International Congress in Parasitology, 2006, Glasgow. ICOPA XI - International Congress in Parasitology, 2006. v. x.
CESTARI, I. S. . Mechanism of Lectin Complement Pathway activation by T. cruzi. In: XXXII Annual Meeting on basic research in Chagas Disease, 2005, Caxambu, MG. XXXII Annual Meeting on basic research in Chagas Disease, 2005. v. 1. p. 149-149.
CESTARI, I. S. ; HAVER, Nicolaas Johannes ; BARBOSA-SILVA, Adriano ; ARAYA, Marcel Ivan Ramirez . A new annotation of trypanosomatids hypothetical proteins searching motifs and domains as functional patterns. In: XX Meeting of the SBPZ, 2004, Caxambu-MG, 2004.
CESTARI, I. S. ; Carvalho, ARB ; SILVA, RL ; RAMIREZ, Marcel Ivan . Prot-OGIM: A novel software to identify motifs in orphan genes from protozoan geneme programs. In: International Congress of Chagas Disease, 2003, Caxambu. Revista do Instituto de Medicina Tropical de São Paulo, 2003. v. 45. p. 157-157.
CESTARI, I. S. ; FREITAS, JC ; DALIRY, A ; OSSES, Ingrid Solange Evans ; ARAYA, Marcel Ivan Ramirez . Early mechanism of complement-mediated lysis are different among T. Cruzi lineage. In: International Congress of Chagas Disease, 2003, Caxambu-MG. Revista do Instituto de Medicina Tropical de São Paulo (Impresso), 2003. v. 45. p. 136-137.
CESTARI, I. S. ; FREITAS, JC ; INAL, Jameel ; RAMIREZ, Marcel Ivan . Diferentes Mecanismos de Ativação do Sistema Complemento em Tripanossomatídeos. In: I Jornada Norte Nordeste de Iniciação Científica FIOCRUZ, 2002, Salvador. I Jornada Norte Nordeste de Iniciação Científica FIOCRUZ, 2002. v. I.
CESTARI, I. S. ; FREITAS, JC ; INAL, JM ; ARAYA, Marcel Ivan Ramirez . Dissecting the mecanism of resistence to complement-mediated lysis on trypanosomatids. In: International Congress of Chagas Disease, 2002, Caxambu-MG. Revista do Instituto de Medicina Tropical de São Paulo (Impresso), 2002. v. 44. p. 128-128.
CESTARI, I. S. ; Krarup, A. ; Sim, R.B. ; INAL, Jameel ; RAMIREZ, Marcel Ivan . Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi.. Molecular Immunology , 2009.
CESTARI, I. S. ; Ansa-Addo, E. ; RAMIREZ, Marcel Ivan ; INAL, JM . Trypanosoma cruzi and the complement system: Mecanism of lectin pathway activation and the role of microvesicles in the evasion of lysis. 2008. (Apresentação de Trabalho/Comunicação).
CESTARI, I. S. ; RAMIREZ, Marcel Ivan . Mecanismo de evasao ao sistema complemento pelo Trypanosoma cruzi. 2003. (Apresentação de Trabalho/Seminário).

Outras produções

CESTARI, I. S. ; HAVER, Nicolaas Johannes ; BARBOSA-SILVA, Adriano ; ARAYA, Marcel Ivan Ramirez . PROTOGIM (Protozoan Gene Identification Motifs). 2004.

Projetos de pesquisa

2022 - Atual

Therapeutic peptides for Chagas disease: a new approach to cardiovascular diseases, Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (6) . , Integrantes: Igor dos Santos Cestari - Coordenador / Nir Qvit - Integrante / Guillermo Daniel Alonso - Integrante., Financiador(es): International Development Research Centre - Auxílio financeiro.
2020 - 2023

Lexpression des gènes dévasion immunitaire et variation antigénique des trypanosomes, Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: / Mestrado profissional: (1) / Doutorado: (1) . , Integrantes: Igor dos Santos Cestari - Coordenador., Financiador(es): Fonds de recherche du Québec - Nature et technologies - Auxílio financeiro.
2020 - Atual

Transcriptional control of telomeric expression sites and antigenic variation, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Igor dos Santos Cestari - Coordenador., Financiador(es): Canada Foundation for Innovation - Auxílio financeiro.
2020 - Atual

Signalling and regulation of antigenic variation in trypanosomes, Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: / Mestrado profissional: (2) / Doutorado: (3) . , Integrantes: Igor dos Santos Cestari - Coordenador., Financiador(es): Canadian Institute for Health Research - Auxílio financeiro.
2019 - Atual

Transcriptional control of telomeric expression sites and antigenic variation, Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (2) . , Integrantes: Igor dos Santos Cestari - Coordenador., Financiador(es): Natural Sciences and Engineering Research Council - Auxílio financeiro.

Prêmios

2024

William Dawson Scholar Award, McGill University.

2019

NSERC Discovery Launch Supplement Award, Natural Sciences and Engineering Research Council of Canada.

2015

Zigman Brener award, Brazilian Society of Protozoology.

2015

F1000Prime Recommendation, Faculty of 1000.

2009

Walter Colli Prize, 13th International Congress of Protistology.

2005

Menção Honrosa, Sociedade Brasileira de Protozoologia, XXXII Annual Meeting on basic research in Chagas Disease.

Histórico profissional

Endereço profissional

McGill University, Institute of Parasitology. , 21111 Lakeshore Rd, Quebec District, H9X3V9 - Sainte-Anne-De-Bellevue, - Canadá, Telefone: (514) 6988729, URL da Homepage:

Experiência profissional

2024 - Atual

McGill University

Vínculo: Formal labor contract, Enquadramento Funcional: Associate Professor, Regime: Dedicação exclusiva.

2018 - 2024

McGill University

Vínculo: Formal labor contract, Enquadramento Funcional: Assistant Professor, Regime: Dedicação exclusiva.

2008 - 2008

MRC Immunochemistry Unit, University of Oxford

Vínculo: Visitor Research, Enquadramento Funcional: Visitor Research, Carga horária: 40, Regime: Dedicação exclusiva.

2007 - 2008

London Metropolitan University

Vínculo: PhD Collaborative degree, Enquadramento Funcional: Visitor Research, Carga horária: 40, Regime: Dedicação exclusiva.

2007 - 2007

Welcome trust for molecular parasitology - University of Glasgow

Vínculo: Visitor Research, Enquadramento Funcional: Visitor Research, Carga horária: 40, Regime: Dedicação exclusiva.

2010 - 2018

Seattle Biomedical Research Institute, Seattle BioMed

Vínculo: Formal labor contract, Enquadramento Funcional: Postdoctoral Scientist, Carga horária: 40