Opher Gileadi

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Produções bibliográficas

• AGAJANIAN, MEGAN J. WALKER, MATTHEW P. AXTMAN, ALISON D. RUELA-DE-SOUSA, ROBERTA R. SERAFIN, D. STEPHEN RABINOWITZ, ALEX D. GRAHAM, DAVID M. RYAN, MEAGAN B. TAMIR, TIGIST NAKAMICHI, YUKO GAMMONS, MELISSA V. BENNETT, JAMES M. COUÑAGO, RAFAEL M. DREWRY, DAVID H. ELKINS, JONATHAN M. GILEADI, CARINA GILEADI, OPHER GODOI, PAULO H. KAPADIA, NIRAV MÜLLER, SUSANNE SANTIAGO, ANDRÉ S. SORRELL, FIONA J. WELLS, CARROW I. FEDOROV, OLEG WILLSON, TIMOTHY M. , et al. ZUERCHER, WILLIAM J. MAJOR, MICHAEL B. ; WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Reports , v. 26, p. 79-93.e8, 2019.

• BULBROOK, D. ; BRAZIER, H. ; MAHAJAN, P. ; KLISZCZAK, M. ; FEDOROV, O. ; MARCHESE, F.P. ; AUBAREDA, A. ; CHALK, R. ; PICAUD, S. ; STRAIN-DAMERELL, C. ; FILIPPAKOPOULOS, P. ; Gileadi, O. ; CLARK, A.R. ; YUE, W.W. ; BURGESS-BROWN, N.A. ; DEAN, J.L.E. . Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment. JOURNAL OF MOLECULAR BIOLOGY , v. 430, p. 722-736, 2018.

• SANTIAGO, ANDRÉ DA SILVA ; COUÑAGO, RAFAEL M. ; RAMOS, PRISCILA ZONZINI ; GODOI, PAULO H. C. ; MASSIRER, KATLIN B. ; GILEADI, OPHER ; ELKINS, JONATHAN M. . Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors. Scientific Reports , v. 8, p. 14800, 2018.

• NEWMAN, JOSEPH A. ; AITKENHEAD, HAZEL ; SAVITSKY, PAVEL ; GILEADI, OPHER . Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5. NUCLEIC ACIDS RESEARCH (ONLINE) , v. 45, p. 4231-4243, 2017.

• BRADLEY, ANTHONY R. ; ECHALIER, AUDE ; FAIRHEAD, MICHAEL ; STRAIN-DAMERELL, CLAIRE ; BRENNAN, PAUL ; BULLOCK, ALEX N. ; BURGESS-BROWN, NICOLA A. ; CARPENTER, ELISABETH P. ; GILEADI, OPHER ; MARSDEN, BRIAN D. ; LEE, WEN HWA ; YUE, WYATT ; BOUNTRA, CHAS ; VON DELFT, FRANK . The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery. Essays in Biochemistry , v. 61, p. 495-503, 2017.

• COUÑAGO, RAFAEL M. ; ALLERSTON, CHARLES K. ; SAVITSKY, PAVEL ; AZEVEDO, HATYLAS ; GODOI, PAULO H. ; WELLS, CARROW I. ; MASCARELLO, ALESSANDRA ; DE SOUZA GAMA, FERNANDO H. ; MASSIRER, KATLIN B. ; ZUERCHER, WILLIAM J. ; GUIMARÃES, CRISTIANO R. W. ; GILEADI, OPHER . Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Scientific Reports , v. 7, p. 7501, 2017.

• DREWRY, DAVID H. ; WELLS, CARROW I. ; ANDREWS, DAVID M. ; ANGELL, RICHARD ; AL-ALI, HASSAN ; AXTMAN, ALISON D. ; CAPUZZI, STEPHEN J. ; ELKINS, JONATHAN M. ; ETTMAYER, PETER ; FREDERIKSEN, MATHIAS ; GILEADI, OPHER ; GRAY, NATHANAEL ; HOOPER, ALICE ; KNAPP, STEFAN ; LAUFER, STEFAN ; LUECKING, ULRICH ; MICHAELIDES, MICHAEL ; MÜLLER, SUSANNE ; MURATOV, EUGENE ; DENNY, R. ALDRIN ; SAIKATENDU, KUMAR S. ; TREIBER, DANIEL K. ; ZUERCHER, WILLIAM J. ; WILLSON, TIMOTHY M. . Progress towards a public chemogenomic set for protein kinases and a call for contributions. PLoS One , v. 12, p. e0181585, 2017.

• AQUINO, BRUNO ; COUÑAGO, RAFAEL M. ; VERZA, NATALIA ; FERREIRA, LUCAS M. ; MASSIRER, KATLIN B. ; GILEADI, OPHER ; ARRUDA, PAULO . Structural Characterization of Maize SIRK1 Kinase Domain Reveals an Unusual Architecture of the Activation Segment. Frontiers in Plant Science , v. 8, p. 852, 2017.

• NEWMAN, JOSEPH A. ; COOPER, CHRISTOPHER D. O. ; ROOS, ANETTE K. ; AITKENHEAD, HAZEL ; OPPERMANN, UDO C. T. ; CHO, HEARN J. ; OSMAN, ROMAN ; GILEADI, OPHER . Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding. Plos One , v. 11, p. e0148762, 2016.

• LEVY, SHIRI ; ALLERSTON, CHARLES K. ; LIVEANU, VARDA ; HABIB, MOUNA R. ; GILEADI, OPHER ; SCHUSTER, GADI . Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease. Nucleic Acids Research , v. 44, p. 1813-1832, 2016.

• BRODERICK, RONAN ; NIEMINUSZCZY, JADWIGA ; BADDOCK, HANNAH T. ; DESHPANDE, RAJASHREE A. ; GILEADI, OPHER ; PAULL, TANYA T. ; MCHUGH, PETER J. ; NIEDZWIEDZ, WOJCIECH . EXD2 promotes homologous recombination by facilitating DNA end resection. Nature Cell Biology , v. 18, p. 271-280, 2016.

• LEE, SOOK Y. ; BREM, JÜRGEN ; PETTINATI, ILARIA ; CLARIDGE, TIMOTHY D. W. ; GILEADI, OPHER ; SCHOFIELD, CHRISTOPHER J. ; MCHUGH, PETER J. . Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo. Chemical Communications (London. 1996. Print) , v. 2016, p. 0000, 2016.

• VAZ, BRUNO ; POPOVIC, MARTA ; NEWMAN, JOSEPH A. ; FIELDEN, JOHN ; AITKENHEAD, HAZEL ; HALDER, SWAGATA ; SINGH, ABHAY NARAYAN ; VENDRELL, IOLANDA ; FISCHER, ROMAN ; TORRECILLA, IGNACIO ; DROBNITZKY, NEELE ; FREIRE, RAIMUNDO ; AMOR, DAVID J. ; LOCKHART, PAUL J. ; KESSLER, BENEDIKT M. ; MCKENNA, GILLIES W. ; GILEADI, OPHER ; RAMADAN, KRISTIJAN . Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair. MOLECULAR CELL , v. 64, p. 704-719, 2016.

• PIKE, ASHLEY C. W. ; GOMATHINAYAGAM, SHIVASANKARI ; SWUEC, PAOLO ; BERTI, MATTEO ; ZHANG, YING ; SCHNECKE, CHRISTINA ; MARINO, FRANCESCA ; VON DELFT, FRANK ; RENAULT, LUDOVIC ; COSTA, ALESSANDRO ; GILEADI, OPHER ; VINDIGNI, ALESSANDRO . Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures. Proceedings of the National Academy of Sciences of the United States of America , v. 112, p. 4286-4291, 2015.

• NEWMAN, JOSEPH A ; COOPER, CHRISTOPHER D. O. ; AITKENHEAD, HAZEL ; GILEADI, OPHER . Structural Insights into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2. The Journal of Biological Chemistry (Print) , v. 290, p. 8539-8549, 2015.

• IYAMA, T. ; LEE, S. Y. ; BERQUIST, B. R. ; Gileadi, O. ; BOHR, V. A. ; SEIDMAN, M. M. ; MCHUGH, P. J. ; WILSON, D. M. . CSB interacts with SNM1A and promotes DNA interstrand crosslink processing. Nucleic Acids Research , v. 43, p. 247-258, 2015.

• NEWMAN, J. A. ; SAVITSKY, P. ; ALLERSTON, C. K. ; BIZARD, A. H. ; OZER, O. ; SARLOS, K. ; LIU, Y. ; PARDON, E. ; STEYAERT, J. ; HICKSON, I. D. ; Gileadi, O. . Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes. Nucleic Acids Research , v. 43, p. 5221-5235, 2015.

• COOPER, CHRISTOPHER D. O. ; NEWMAN, JOSEPH A. ; AITKENHEAD, HAZEL ; ALLERSTON, CHARLES K. ; GILEADI, OPHER . Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev. The Journal of Biological Chemistry (Print) , v. 290, p. 13692-13709, 2015.

• ALLERSTON, CHARLES K. ; LEE, SOOK Y. ; NEWMAN, JOSEPH A. ; SCHOFIELD, CHRISTOPHER J. ; MCHUGH, PETER J. ; GILEADI, OPHER . The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities. Nucleic Acids Research (Online) , v. 43, p. 11047-11060, 2015.

• BREM, JÜRGEN ; VAN BERKEL, SANDER S. ; ZOLLMAN, DAVID ; LEE, SOOK Y. ; GILEADI, OPHER ; MCHUGH, PETER J. ; WALSH, TIMOTHY R. ; MCDONOUGH, MICHAEL A. ; SCHOFIELD, CHRISTOPHER J. . Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers. Antimicrobial Agents and Chemotherapy (Print) , v. 60, p. 142-150, 2015.

• NEWMAN, JOSEPH A. ; COOPER, CHRISTOPHER D.O. ; AITKENHEAD, HAZEL ; GILEADI, OPHER . Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway. Structure (London) , v. 23, p. 2319-2330, 2015.

• COOPER, CHRISTOPHER D.O. ; NEWMAN, JOSEPH A. ; GILEADI, OPHER . Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition. Biochemical Society Transactions , v. 42, p. 130-138, 2014.

• GILEADI, OPHER . Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development. Biochemical Society Transactions , v. 42, p. 108-113, 2014.

• CHATTERJEE, SUJOY ; ZAGELBAUM, JENNIFER ; SAVITSKY, PAVEL ; STURZENEGGER, ANDREAS ; HUTTNER, DIANA ; JANSCAK, PAVEL ; HICKSON, IAN D. ; GILEADI, OPHER ; ROTHENBERG, ELI . Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures. Nature Communications , v. 5, p. 5556, 2014.

• ROSENTHAL, ANDREW S. ; DEXHEIMER, THOMAS S. ; GILEADI, OPHER ; NGUYEN, GIANG H. ; CHU, WAI KIT ; HICKSON, IAN D. ; JADHAV, AJIT ; SIMEONOV, ANTON ; MALONEY, DAVID J. . Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorganic & Medicinal Chemistry Letters (Print) , v. 23, p. 5660-5666, 2013.

• FROESE, D. SEAN FOROUHAR, FARHAD TRAN, TIMOTHY H. VOLLMAR, MELANIE KIM, YI SEUL LEW, SCOTT NEELY, HELEN SEETHARAMAN, JAYARAMAN SHEN, YANG XIAO, RONG ACTON, THOMAS B. EVERETT, JOHN K. CANNONE, GIUSEPPE PURANIK, SRIHARSHA SAVITSKY, PAVEL KROJER, TOBIAS PILKA, EWA S. KIYANI, WASIM LEE, WEN HWA MARSDEN, BRIAN D. VON DELFT, FRANK ALLERSTON, CHARLES K. SPAGNOLO, LAURA GILEADI, OPHER MONTELIONE, GAETANO T. , et al. OPPERMANN, UDO YUE, WYATT W. TONG, LIANG ; Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations. Structure (London) , v. 21, p. 1182-1192, 2013.

• SHINTRE, C. A. ; PIKE, A. C. W. ; LI, Q. ; KIM, J.-I. ; BARR, A. J. ; GOUBIN, S. ; SHRESTHA, L. ; YANG, J. ; BERRIDGE, G. ; ROSS, J. ; STANSFELD, P. J. ; SANSOM, M. S. P. ; EDWARDS, A. M. ; BOUNTRA, C. ; MARSDEN, B. D. ; VON DELFT, F. ; BULLOCK, A. N. ; GILEADI, O. ; BURGESS-BROWN, N. A. ; CARPENTER, E. P. . Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proceedings of the National Academy of Sciences of the United States of America , v. 110, p. 9710-9715, 2013.

• BABBS, C. ; ROBERTS, N. A. ; SANCHEZ-PULIDO, L. ; MCGOWAN, S. J. ; AHMED, M. R. ; BROWN, J. M. ; SABRY, M. A. ; BENTLEY, D. R. ; MCVEAN, G. A. ; DONNELLY, P. ; GILEADI, O. ; PONTING, C. P. ; HIGGS, D. R. ; BUCKLE, V. J. . Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I. Haematologica (Roma) , v. 98, p. 1383-1387, 2013.

• ALLERSTON, CHARLES K. ; VON DELFT, FRANK ; GILEADI, OPHER . Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase. Plos One , v. 8, p. e57644, 2013.

• NGUYEN, GIANG HUONG ; DEXHEIMER, THOMAS S. ; ROSENTHAL, ANDREW S. ; CHU, WAI KIT ; SINGH, DHARMENDRA KUMAR ; MOSEDALE, GEORGINA ; BACHRATI, CSANÁD Z. ; SCHULTZ, LENA ; SAKURAI, MASAAKI ; SAVITSKY, PAVEL ; ABU, MIKA ; MCHUGH, PETER J. ; BOHR, VILHELM A. ; HARRIS, CURTIS C. ; JADHAV, AJIT ; GILEADI, OPHER ; MALONEY, DAVID J. ; SIMEONOV, ANTON ; HICKSON, IAN D. . A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells. Chemistry & Biology (London) , v. 20, p. 55-62, 2013.

• CANNING, P. ; COOPER, C. D. O. ; KROJER, T. ; MURRAY, J. W. ; PIKE, A. C. W. ; CHAIKUAD, A. ; KEATES, T. ; THANGARATNARAJAH, C. ; HOJZAN, V. ; MARSDEN, B. D. ; GILEADI, O. ; KNAPP, S. ; VON DELFT, F. ; BULLOCK, A. N. . Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases. The Journal of Biological Chemistry (Print) , v. 288, p. 7803-7814, 2013.

• TWIGG, STEPHEN R.F. ; LLOYD, DEBORAH ; JENKINS, DAGAN ; ELÇIOGLU, NURSEL E. ; COOPER, CHRISTOPHER D.O. ; AL-SANNAA, NOURIYA ; ANNAGÜR, ALI ; GILLESSEN-KAESBACH, GABRIELE ; HÜNING, IRINA ; KNIGHT, SAMANTHA J.L. ; GOODSHIP, JUDITH A. ; KEAVNEY, BERNARD D. ; BEALES, PHILIP L. ; GILEADI, OPHER ; MCGOWAN, SIMON J. ; WILKIE, ANDREW O.M. . Mutations in Multidomain Protein MEGF8 Identify a Carpenter Syndrome Subtype Associated with Defective Lateralization. American Journal of Human Genetics , v. 91, p. 897-905, 2012.

• SENGEROVA, B. ; ALLERSTON, C. K. ; ABU, M. ; LEE, S. Y. ; HARTLEY, J. ; KIAKOS, K. ; SCHOFIELD, C. J. ; HARTLEY, J. A. ; GILEADI, O. ; MCHUGH, P. J. . Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases. The Journal of Biological Chemistry (Print) , v. 287, p. 26254-26267, 2012.

• WATSON, ALEKSANDRA A. ; MAHAJAN, PRAVIN ; MERTENS, HAYDYN D.T. ; DEERY, MICHAEL J. ; ZHANG, WENCHAO ; PHAM, PETER ; DU, XIUXIA ; BARTKE, TILL ; ZHANG, WEI ; EDLICH, CHRISTIAN ; BERRIDGE, GEORGINA ; CHEN, YUN ; BURGESS-BROWN, NICOLA A. ; KOUZARIDES, TONY ; WIECHENS, NICOLA ; OWEN-HUGHES, TOM ; SVERGUN, DMITRI I. ; GILEADI, OPHER ; LAUE, ERNEST D. . The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4. Journal of Molecular Biology , v. 422, p. 3-17, 2012.

• KEATES, TRACY ; COOPER, CHRISTOPHER D.O. ; SAVITSKY, PAVEL ; ALLERSTON, CHARLES K. ; PHILLIPS, CLAIRE ; HAMMARSTRÖM, MARTIN ; DAGA, NEHA ; BERRIDGE, GEORGINA ; MAHAJAN, PRAVIN ; BURGESS-BROWN, NICOLA A. ; MÜLLER, SUSANNE ; GRÄSLUND, SUSANNE ; GILEADI, OPHER . Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation. New Biotechnology (Print) , v. 29, p. 515-525, 2012.

• KRASTANOVA, I. ; SANNINO, V. ; AMENITSCH, H. ; GILEADI, O. ; PISANI, F. M. ; ONESTI, S. . Structural and Functional Insights into the DNA Replication Factor Cdc45 Reveal an Evolutionary Relationship to the DHH Family of Phosphoesterases. The Journal of Biological Chemistry (Print) , v. 287, p. 4121-4128, 2012.

• WANG, A. T. ; SENGEROVA, B. ; CATTELL, E. ; INAGAWA, T. ; HARTLEY, J. M. ; KIAKOS, K. ; BURGESS-BROWN, N. A. ; SWIFT, L. P. ; ENZLIN, J. H. ; SCHOFIELD, C. J. ; GILEADI, O. ; HARTLEY, J. A. ; MCHUGH, P. J. . Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes & Development , v. 25, p. 1859-1870, 2011.

• PICAUD, SARAH ; KAVANAGH, KATHRYN L. ; YUE, WYATT W. ; LEE, WEN HWA ; MULLER-KNAPP, SUSANNE ; GILEADI, OPHER ; SACCHETTINI, JAMES ; OPPERMANN, UDO . Structural basis of fumarate hydratase deficiency. Journal of Inherited Metabolic Disease , v. 34, p. 671-676, 2011.

• CHEN, D. ; VOLLMAR, M. ; ROSSI, M. N. ; PHILLIPS, C. ; KRAEHENBUEHL, R. ; SLADE, D. ; MEHROTRA, P. V. ; VON DELFT, F. ; CROSTHWAITE, S. K. ; GILEADI, O. ; DENU, J. M. ; AHEL, I. . Identification of Macrodomain Proteins as Novel O-Acetyl-ADP-ribose Deacetylases. The Journal of Biological Chemistry (Print) , v. 286, p. 13261-13271, 2011.

• BERRIDGE, GEORGINA ; CHALK, ROD ; D'AVANZO, NAZZARENO ; DONG, LIANG ; DOYLE, DECLAN ; KIM, JUNG-IN ; XIA, XIAOBING ; BURGESS-BROWN, NICOLA ; DERISO, ANTONIO ; CARPENTER, ELISABETH PAULA ; GILEADI, OPHER . High-performance liquid chromatography separation and intact mass analysis of detergent-solubilized integral membrane proteins. Analytical Biochemistry (Print) , v. 410, p. 272-280, 2011.

• LUCIC, B. ; ZHANG, Y. ; KING, O. ; MENDOZA-MALDONADO, R. ; BERTI, M. ; NIESEN, F. H. ; BURGESS-BROWN, N. A. ; PIKE, A. C. W. ; COOPER, C. D. O. ; GILEADI, O. ; VINDIGNI, A. . A prominent  -hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation. Nucleic Acids Research , v. 39, p. 1703-1717, 2011.

• PANIGRAHI, G. B. ; SLEAN, M. M. ; SIMARD, J. P. ; GILEADI, O. ; PEARSON, C. E. . Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutS , but clustered slip-outs are poorly repaired. Proceedings of the National Academy of Sciences of the United States of America , v. 107, p. 12593-12598, 2010.

• SAVITSKY, PAVEL ; BRAY, JAMES ; COOPER, CHRISTOPHER D.O. ; MARSDEN, BRIAN D. ; MAHAJAN, PRAVIN ; BURGESS-BROWN, NICOLA A. ; GILEADI, OPHER . High-throughput production of human proteins for crystallization: The SGC experience. Journal of Structural Biology (Print) , v. 172, p. 3-13, 2010.

• VINDIGNI, ALESSANDRO ; MARINO, FRANCESCA ; GILEADI, OPHER . Probing the structural basis of RecQ helicase function. Biophysical Chemistry (Print) , v. 149, p. 67-77, 2010.

• PIKE, A. C. W. ; SHRESTHA, B. ; POPURI, V. ; BURGESS-BROWN, N. ; MUZZOLINI, L. ; COSTANTINI, S. ; VINDIGNI, A. ; GILEADI, O. . Structure of the human RECQ1 helicase reveals a putative strand-separation pin. Proceedings of the National Academy of Sciences of the United States of America , v. 106, p. 1039-1044, 2009.

• GRÄSLUND, SUSANNE NORDLUND, PÄR WEIGELT, JOHAN BRAY, JAMES GILEADI, OPHER KNAPP, STEFAN OPPERMANN, UDO ARROWSMITH, CHERYL HUI, RAYMOND MING, JINRONG DHE-PAGANON, SIRANO PARK, HEE-WON SAVCHENKO, ALEXEI YEE, ADELINDA EDWARDS, ALED VINCENTELLI, RENAUD CAMBILLAU, CHRISTIAN KIM, ROSALIND KIM, SUNG-HOU RAO, ZIHE SHI, YUNYU TERWILLIGER, THOMAS C KIM, CHANG-YUB HUNG, LI-WEI WALDO, GEOFFREY S , et al. PELEG, YOAV ALBECK, SHIRA UNGER, TAMAR DYM, ORLY PRILUSKY, JAIME SUSSMAN, JOEL L STEVENS, RAY C LESLEY, SCOTT A WILSON, IAN A JOACHIMIAK, ANDRZEJ COLLART, FRANK DEMENTIEVA, IRINA DONNELLY, MARK I ESCHENFELDT, WILLIAM H KIM, YOUNGCHANG STOLS, LUCY WU, RUYING ZHOU, MIN BURLEY, STEPHEN K EMTAGE, J SPENCER SAUDER, J MICHAEL THOMPSON, DEVON BAIN, KEVIN LUZ, JOHN GHEYI, TARUN ZHANG, FRED ATWELL, SHANE ALMO, STEVEN C BONANNO, JEFFREY B FISER, ANDRAS SWAMINATHAN, SIVASUBRAMANIAN STUDIER, F WILLIAM CHANCE, MARK R SALI, ANDREJ ACTON, THOMAS B XIAO, RONG ZHAO, LI MA, LI CHUNG HUNT, JOHN F TONG, LIANG CUNNINGHAM, KELLIE INOUYE, MASAYORI ANDERSON, STEPHEN JANJUA, HELEEMA SHASTRY, RITU HO, CHI KENT WANG, DONGYAN WANG, HUANG JIANG, MEI MONTELIONE, GAETANO T STUART, DAVID I OWENS, RAYMOND J DAENKE, SUSAN SCHÜTZ, ANJA HEINEMANN, UDO YOKOYAMA, SHIGEYUKI BÜSSOW, KONRAD GUNSALUS, KRISTIN C ; Protein production and purification. Nature Methods , v. 5, p. 135-146, 2008.

• BURGESS-BROWN, NICOLA A. ; SHARMA, SUJATA ; SOBOTT, FRANK ; LOENARZ, CHRISTOPH ; OPPERMANN, UDO ; GILEADI, OPHER . Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. Protein Expression and Purification (Print) , v. 59, p. 94-102, 2008.

• Gileadi O ; BURGESS-BROWN, N. A. ; COLEBROOK, S. M. ; BERRIDGE, G. ; SAVITSKY, P. ; SMEE, C. E. A. ; LOPPNAU, P. ; JOHANSSON, C. ; SALAH, E. ; PANTIC, N. H. . High throughput production of recombinant human proteins for crystallography.. Methods in Molecular Biology (Clifton, N.J.) , v. 426, p. 221, 2008.

• NG, STANLEY S. ; KAVANAGH, KATHRYN L. ; MCDONOUGH, MICHAEL A. ; BUTLER, DANICA ; PILKA, EWA S. ; LIENARD, BENOIT M. R. ; BRAY, JAMES E. ; SAVITSKY, PAVEL ; GILEADI, OPHER ; VON DELFT, FRANK ; ROSE, NATHAN R. ; OFFER, JOHN ; SCHEINOST, JOHANNA C. ; BOROWSKI, TOMASZ ; SUNDSTROM, MICHAEL ; SCHOFIELD, CHRISTOPHER J. ; OPPERMANN, UDO . Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature (London) , v. 448, p. 87-91, 2007.

• GILEADI, OPHER ; KNAPP, STEFAN ; LEE, WEN HWA ; MARSDEN, BRIAN D. ; MÜLLER, SUSANNE ; NIESEN, FRANK H. ; KAVANAGH, KATHRYN L. ; BALL, LINDA J. ; DELFT, FRANK ; DOYLE, DECLAN A. ; OPPERMANN, UDO C. T. ; SUNDSTRÖM, MICHAEL . The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins. Journal of Structural and Functional Genomics , v. 8, p. 107-119, 2007.

• JOHANSSON, C. ; KAVANAGH, K. L. ; GILEADI, O. ; OPPERMANN, U. . Reversible Sequestration of Active Site Cysteines in a 2Fe-2S-bridged Dimer Provides a Mechanism for Glutaredoxin 2 Regulation in Human Mitochondria. The Journal of Biological Chemistry (Print) , v. 282, p. 3077-3082, 2007.

• AMIT, R. ; GILEADI, O. ; STAVANS, J. . Direct observation of RuvAB-catalyzed branch migration of single Holliday junctions. Proceedings of the National Academy of Sciences of the United States of America , v. 101, p. 11605-11610, 2004.

• NYSKA, ABRAHAM ; CUMMINGS, CONNIE ; VAINSHTEIN, ANYA ; NADLER, JONATHAN ; EZOV, NATHAN ; GRUNFELD, YONA ; GILEADI, OPHER ; BEHAR, VERED . Electron Microscopy of Wet Tissues: A Case Study in Renal Pathology. Toxicologic Pathology (Print) , v. 32, p. 357-363, 2004.

• THIBERGE, S. ; NECHUSHTAN, A. ; SPRINZAK, D. ; GILEADI, O. ; BEHAR, V. ; ZIK, O. ; CHOWERS, Y. ; MICHAELI, S. ; SCHLESSINGER, J. ; MOSES, E. . Scanning electron microscopy of cells and tissues under fully hydrated conditions. Proceedings of the National Academy of Sciences of the United States of America , v. 101, p. 3346-3351, 2004.

• BARSHACK, IRIS ; KOPOLOVIC, JURI ; CHOWERS, YEHUDA ; GILEADI, OPHER ; VAINSHTEIN, ANYA ; ZIK, ORY ; BEHAR, VERED . A Novel Method for -Wet- SEM. Ultrastructural Pathology , v. 28, p. 29-31, 2004.

• GILEADI, OPHER ; SABBAN, ALON . Squid Sperm to Clam Eggs: Imaging Wet Samples in a Scanning Electron Microscope. The Biological Bulletin (Lancaster) , v. 205, p. 177, 2003.

• ALI, B. M. J. ; AMIT, R. ; BRASLAVSKY, I. ; OPPENHEIM, A. B. ; Gileadi, O. ; STAVANS, J. . Compaction of single DNA molecules induced by binding of integration host factor (IHF). Proceedings of the National Academy of Sciences of the United States of America , v. 98, p. 10658-10663, 2001.

• JONA, GHIL ; WITTSCHIEBEN, BIRGITTE Ø. ; SVEJSTRUP, JESPER Q. ; GILEADI, OPHER . Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo. Gene (Amsterdam) , v. 267, p. 31-36, 2001.

• BRASLAVSKY, I. ; AMIT, R. ; Jaffar Ali BM ; Gileadi O. ; OPPENHEIM, A. B. ; STAVANS, J. . Objective-type dark-field illumination for scattering from microbeads.. Applied Optics , v. 40, p. 5650, 2001.

• JONA, GHIL ; CHODER, MORDECHAI ; GILEADI, OPHER . Glucose starvation induces a drastic reduction in the rates of both transcription and degradation of mRNA in yeast. Biochimica et Biophysica Acta, N. Gene Structure and Expression , v. 1491, p. 37-48, 2000.

• OSTAPENKO, DENIS ; GILEADI, OPHER . Rad25p, a DNA helicase subunit of yeast transcription factor TFIIH, is required for promoter escape in vivo. Gene (Amsterdam) , v. 245, p. 109-117, 2000.

• KOBOR, MICHAEL S ; ARCHAMBAULT, JACQUES ; LESTER, WILLIAM ; HOLSTEGE, FRANK C.P ; GILEADI, OPHER ; JANSMA, DAVID B ; JENNINGS, EZRA G ; KOUYOUMDJIAN, FIONA ; DAVIDSON, ALAN R ; YOUNG, RICHARD A ; GREENBLATT, JACK . An Unusual Eukaryotic Protein Phosphatase Required for Transcription by RNA Polymerase II and CTD Dephosphorylation in S. cerevisiae. Molecular Cell , v. 4, p. 55-62, 1999.

• ESPINOZA, F. ; Gileadi O. ; FARRELL, A. ; NOURSE, J. ; CHAMBERLIN, H. ; MORGAN, D. . Cak1 is required for Kin28 phosphorylation and activation in vivo.. Molecular and Cellular Biology (Print) , v. 18, p. 6365, 1998.

• FRIDLENDER, M. ; SITRIT, Y. ; SHAUL, O. ; Gileadi O. ; LEVI, A. . Analysis of the Ac promoter: structure and regulation.. Molecular Genetics and Genomics (Print) , v. 258, p. 306, 1998.

• Gileadi, O. . Partial Truncation of the Yeast RNA Polymerase II Carboxyl-terminal Domain Preferentially Reduces Expression of Glycolytic Genes. The Journal of Biological Chemistry (Print) , v. 270, p. 31255-31261, 1995.

• FEAVER, WILLIAM J. ; HENRY, N. L. ; BUSHNELL, D. A. ; SAYRE, M. H. ; BRICKNER, J. ; Gileadi O. ; KORNBERG, ROGER D. . Yeast TFIIE. Cloning, expression, and homology to vertebrate proteins.. The Journal of Biological Chemistry (Print) , v. 269, p. 27549, 1994.

• Gileadi, O ; FEAVER, W. ; KORNBERG, R. . Cloning of a subunit of yeast RNA polymerase II transcription factor b and CTD kinase. Science (New York, N.Y.) , v. 257, p. 1389-1392, 1992.

• RACHMILEWITZ, J. ; Gileadi, O. ; ELDAR-GEVA, T. ; SCHNEIDER, T. ; DE-GROOT, N. ; HOCHBERG, A. . Transcription of the H19 gene in differentiating cytotrophoblasts from human placenta. Molecular Reproduction and Development , v. 32, p. 196-202, 1992.

• PF'TZ, MARITA ; GILEADI, OPHER ; WERNER, DIETER . Identification of human satellite DNA sequences associated with chemically resistant nonhistone polypeptide adducts. Chromosoma , v. 101, p. 609-617, 1992.

• FEAVER, WILLIAM J. ; GILEADI, OPHER ; LI, YANG ; KORNBERG, ROGER D. . CTD kinase associated with yeast RNA polymerase II initiation factor b. Cell (Cambridge) , v. 67, p. 1223-1230, 1991.

• FEAVER, WILLIAM J. ; Gileadi O. ; KORNBERG, ROGER D. . Purification and characterization of yeast RNA polymerase II transcription factor b.. The Journal of Biological Chemistry (Print) , v. 266, p. 19000-19005, 1991.

• Gileadi, O. ; LORBERBOUM, H. ; GROOT, N. ; HOCHBERG, A. A. . Location of RNase and RNase inhibitor on free cytoplasmic mRNA-protein particles from human placenta. Molecular Biology Reports , v. 9, p. 241-244, 1984.

• GILEADI, OPHER . Recombinant Protein Expression in E. coli : A Historical Perspective. Methods in Molecular Biology. 1ed.: Springer New York, 2017, v. 1586, p. 3-10.

• Opher Gileadi ; VERZA, N.Verza, N . Da inovação aberta à descoberta de medicamentos. EMBRAPA ciencia para vida.

• OWENS, RAYMOND J. ; GILEADI, OPHER . Streamlining the production of proteins for structural biology. BIOPHYSICAL REVIEWS , 2019.

• LIM, MICHAEL ; NEWMAN, JOSEPH A. ; WILLIAMS, HANNAH L. ; MASINO, LAURA ; AITKENHEAD, HAZEL ; GRAVARD, ANGELINE E. ; GILEADI, OPHER ; SVEJSTRUP, JESPER Q. . A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin. STRUCTURE , 2019.

• MUNIZ, JOAO R.C. ; SZETO, NATALIE WING-SUM ; FRISE, REBECCA ; LEE, WEN HWA ; WANG, XIAN-SONG ; THÖNY, BEAT ; HIMMELREICH, NASTASSJA ; BLAU, NENAD ; HSIAO, KWANG-JEN ; LIU, TZE-TZE ; GILEADI, OPHER ; OPPERMANN, UDO ; VON DELFT, FRANK ; YUE, WYATT W. ; TANG, NELSON LEUNG-SANG . Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency. PATHOLOGY , 2019.

• Gileadi, O. ; COUNAGO, R. ; SOUZA, R. R. ; GODOI, P. ; GILEADI, C. ; REIS, M. ; SALMAZO, A. ; VERZA, N. ; MASIRRER, K. ; ARRUDA, P. . Chemical Probes: A Route for Exploration of Under-Studied Protein Kinases as Novel Drug Targets. 2016. (Apresentação de Trabalho/Conferência ou palestra).

Outras produções

Projetos de pesquisa

• 2015 - Atual

  SGC-UNICAMP kinase chemical biology center, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Opher Gileadi - Coordenador / Paulo Arruda - Integrante / Rafael Counago - Integrante., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Bolsa.

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