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SILVA, P. R. ; ALMEIDA, M. ; SILVA, J. M. ; ALBINO, S. ; SANTO, R. F. E. ; VILLARREAL, C. F. ; MOURA, R. O. ; SANTOS, V. L. . E)-2-cyano-3-(indol-3-yl)-N-phenylacrylamide, a Hybrid Compound Derived from Indomethacin and Paracetamol: Design, Synthesis and Evaluation of Anti-inflammatory Potential. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 21, p. 2591, 2020.
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PEREIRA, L. ; ABREU, L. S. ; SILVA, J. ; MACHADO, F. ; QUEIROGA, C. ; SANTO, R. F. E. ; SILVA, D. F. A. ; VILLARREAL, C. F. ; AGRA, M. ; SCOTTI, M. ; TAVARES, J. F. ; SILVA, M. S. . Bioactive Compounds from the Aerial Parts of Evolvulus linarioides. JOURNAL OF NATURAL PRODUCTS , v. May 4, p. 9b01189, 2020.
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LEMOS, PAULO VITOR FRANÇA ; OPRETZKA, LUÍZA CAROLINA FRANÇA ; ALMEIDA, LETÍCIA SANTOS ; CARDOSO, LUCAS GUIMARÃES ; DA SILVA, JÂNIA BETÂNIA ALVES ; DE SOUZA, CAROLINA OLIVEIRA ; Villarreal, Cristiane Flora ; DRUZIAN, JANICE IZABEL . Preparation and characterization of C-phycocyanin coated with STMP/STPP cross-linked starches from different botanical sources. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES , v. May 18, p. S0141-8130(20)3, 2020.
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ABREU, LUCAS SILVA ; DO NASCIMENTO, YURI MANGUEIRA ; DO ESPIRITO-SANTO, RENAN FERNANDES ; MEIRA, CÁSSIO SANTANA ; SANTOS, IVANILSON PIMENTA ; BRANDÃO, RAILDA BATISTA ; SOUTO, AUGUSTO LOPES ; GUEDES, MARIA LENISE SILVA ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora ; DA SILVA, MARCELO SOBRAL ; DA SILVA VELOZO, EUDES ; TAVARES, JOSEAN FECHINE . Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities. FITOTERAPIA , v. May 21, p. 104632, 2020.
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SILVA, L. B. ; CAMARGO, S. B. ; MORAES, R. A. ; MEDEIROS, C. F. A. ; JESUS, A. M. ; EVANGELISTA, A. F. ; VILLARREAL, C. F. ; QUINTAS-JUNIOR, L. J. ; VASCONCELOS, D. F. S. A. . Antihypertensive effect of carvacrol is improved after incorporation in -cyclodextrin as a drug delivery system. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY , v. Jun 22, p. 13364, 2020.
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EVANGELISTA, A. F. ; SOARES, M. B. P. ; VILLARREAL, C. F. . Cell-free therapy: a neuroregenerative approach to sensory neuropathy?. Neural Regeneration Research , v. 14, p. 1383-1384, 2019.
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DOS'SANTOS'COSTA, RAFAEL ; DO'ESPÍRITO-SANTO, RENAN FERNANDES ; ABREU, LUCAS SILVA ; DE'OLIVEIRA'AGUIAR, LEONARDO ; LEITE'FONTES, DARA ; FECHINE'TAVARES, JOSEAN ; SOBRAL'DA'SILVA, MARCELO ; BOTELHO'PEREIRA'SOARES, MILENA ; DA'SILVA'VELOZO, EUDES ; FLORA'VILLARREAL, CRISTIANE . Fluorescent Canthin-6-one Alkaloids from Simaba bahiensis : Isolation, Identification, and Cell-Labeling Properties. ChemPlusChem , v. 84, p. 260-267, 2019.
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OPRETZKA, L. C. F. ; SANTO, R. F. E. ; NASCIMENTO, O. A. ; ABREU, L. S. ; ALVES, I. M. ; DORING, E. ; SOARES, M. B. P. ; Velozo, ES ; LAUFER, S. A. ; VILLARREAL, C. F. . Natural chromones as potential anti-inflammatory agents: pharmacological properties and related mechanisms. INTERNATIONAL IMMUNOPHARMACOLOGY , v. 72, p. 31-39, 2019.
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ROCHA, J. L. C. ; CALUMBY, R. F. A. T. ; SILVA, D. F. ; BRANDAO, H. N. ; VILLARREAL, C. F. ; LIMA, F.O. . Evaluation of Biological Activity of Polygala Boliviensis in Experimental Models. Iranian Journal of Pharmaceutical Research , v. 18, p. 793-802, 2019.
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ALLAHDADI, K. J. ; SANTANA, T. A. ; SANTOS, G. C. ; AZEVEDO, C. M. ; SANTO, R. F. E. ; EVANGELISTA, A. F. ; VILLARREAL, C. F. ; SANTOS, R. R. ; SOUZA, B. S. F. ; SOARES, M. B. P. . IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury. Stem Cell Research & Therapy , v. 10, p. 146, 2019.
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ABREU, L. S. ; ALVES, I. M. ; NASCIMENTO, Y. M. ; DANTAS, C. A. G. ; SANTO, R. F. E. ; Santos, G.G.L. ; SILVA, M. S. ; VILLARREAL, C. F. ; TAVARES, J. F. ; Velozo, ES . Antinociceptive compounds and LC-DAD-ESIMSn profile from Dictyoloma vandellianum leaves. PLoS One , v. 14, p. e0224575, 2019.
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SANTO, R. F. E. ; LIMA, M. S. ; JUIZ, P. J. ; OPRETZKA, L. C. F. ; NOGUEIRA, R. C. ; RIBEIRO, I. M. ; TOMASSINI, T. C. B. ; SOARES, M. B. P. ; VILLARREAL, C. F. . Physalis angulata concentrated ethanolic extract suppresses nociception and inflammation by modulating cytokines and prostanoids pathways. NATURAL PRODUCT RESEARCH , v. 24, p. 1-5, 2019.
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GAMA, K. B. ; SANTOS, D. ; EVANGELISTA, A. F. ; SILVA, D. N. ; ALCANTARA, A. C. ; SANTOS, R. R. ; SOARES, M. B. P. ; Villarreal, CF . Conditioned medium of bone marrow-derived mesenchymal stromal cells as a therapeutic approach to neuropathic pain: a pre-clinical evaluation. Stem Cells International , v. 2018, p. 12, 2018.
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CAMARGO, S. B. ; SIMOES, L. O. ; MEDEIROS, C. F. A. ; JESUS, A. M. ; FREGONEZE, J. B. ; EVANGELISTA, A. F. ; VILLARREAL, C. F. ; QUINTAS-JUNIOR, L. J. ; VASCONCELOS, D. F. S. A. . Antihypertensive potential of linalool and linalool complexed with -cyclodextrin: effects of subchronic treatment on blood pressure and vascular reactivity. BIOCHEMICAL PHARMACOLOGY , v. Feb, p. 15, 2018.
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EVANGELISTA, AFRÂNIO FERREIRA ; VANNIER-SANTOS, MARCOS ANDRÉ ; DE ASSIS SILVA, GESSICA SABRINA ; SILVA, DANIELA NASCIMENTO ; JUIZ, PAULO JOSÉ LIMA ; NONAKA, CAROLINA KYMIE VASQUES ; DOS SANTOS, RICARDO RIBEIRO ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora . Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades. Journal of Neuroinflammation , v. 15, p. 189, 2018.
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LAURIA, P. S. S. ; Silva, L L C ; SANTO, R. F. E. ; SOUZA, C. M. V. ; ZINGALI, R. B. ; CARUSO, M. B. ; SOARES, M. B. P. ; VILLARREAL, C. F. . Pain-like behaviors and local mechanisms involved in the nociception experimentally induced by Latrodectus curacaviensis spider venom. TOXICOLOGY LETTERS , v. Sep 24, p. pii: S0378-427, 2018.
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MOREIRA, DIOGO RODRIGO MAGALHAES ; SANTOS, DOURIVALDO SILVA ; DO ESPÍRITO SANTO, RENAN FERNANDES ; EVANGELISTA DOS SANTOS, FLÁVIA ; DE OLIVEIRA FILHO, GEVANIO BEZERRA ; LEITE, ANA CRISTINA LIMA ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora . Structural improvement of new thiazolidinones compounds with antinociceptive activity in experimental chemotherapy-induced painful neuropathy. Chemical Biology & Drug Design (Print) , v. 21, p. 1757, 2017.
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PAZ, ODAILSON SANTOS ; DE JESUS PINHEIRO, MILENA ; FERNANDES DO ESPIRITO SANTO, RENAN ; Villarreal, Cristiane Flora ; CASTILHO, MARCELO SANTOS . Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 136, p. 487-496, 2017.
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ESPÍRITO-SANTO, RENAN FERNANDES ; MEIRA, CASSIO SANTANA ; COSTA, RAFAEL DOS SANTOS ; SOUZA FILHO, OTÁVIO PASSOS ; EVANGELISTA, AFRANIO FERREIRA ; TROSSINI, GUSTAVO HENRIQUE GOULART ; FERREIRA, GLAUCIO MONTEIRO ; VELOZO, EUDES DA SILVA ; Villarreal, Cristiane Flora ; Pereira Soares, Milena Botelho . The anti-inflammatory and immunomodulatory potential of braylin: Pharmacological properties and mechanisms by in silico, in vitro and in vivo approaches. PLoS One , v. 12, p. e0179174, 2017.
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LAROCCA, T. F. ; MACEDO, C. T. ; SOUZA, B. S. F. ; MASCARENHAS, Y. S. ; VILLARREAL, C. F. ; MATOS, A. C. ; SILVA, D. N. ; SILVA, K. N. ; SOUZA, C. L. E. M. ; SOARES, M. B. P. ; SANTOS, R. R. . Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study. CYTOTHERAPY , p. S1465-3249(17), 2017.
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SÃO PEDRO, ANDRÉ ; FERNANDES, RENAN ; FLORA VILLARREAL, CRISTIANE ; FIALHO, ROSANA ; CABRAL ALBUQUERQUE, ELAINE . Opioid-based micro and nanoparticulate formulations: alternative approach on pain management. Journal of Microencapsulation , v. 1, p. 1-12, 2016.
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PINTOS, L. A. ; MEIRA, C. S. ; VILLARREAL, C. F. ; VANNIER-SANTOS, M. A. ; TOMASSINI, T. C. B. ; GALVAO-CASTRO, B. ; SOARES, M. B. P. ; GRASSI, M. F. R. . Physalin F, a seco-steroid from Physalis angulata L., has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy. Biomedicine & Pharmacotherapy , v. 79, p. 129-134, 2016.
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NASCIMENTO, O. A. ; SANTO, R. F. E. ; OPRETZKA, L. C. F. ; BARBOSA FILHO, J. M. ; GUTIERREZ, S. J. C. ; VILLARREAL, C. F. ; SOARES, M. B. P. . Pharmacological Properties of Riparin IV in Models of Pain and Inflammation. Molecules (Basel. Online) , v. 21, p. 1757, 2016.
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SANTANA, M. F. ; GUIMARAES, A. G. ; CHAVES, D. O. ; SILVA, J. C. ; BONJARDIM, L. R. ; LUCCA JUNIOR, W. ; FERRO, J. N. S. ; BARRETO, E. O. ; SANTO, F. E. ; Pereira Soares, Milena Botelho ; Villarreal, CF ; QUINTANS, J. S. S. ; QUINTAS-JUNIOR, L. J. . The anti-hyperalgesic and anti-inflammatory profiles of p-Cymene: Evidence for the involvement of opioid system and cytokines. Pharmaceutical Biology , v. 9, p. 1-8, 2015.
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SOUZA, GUILHERME R. ; CUNHA, THIAGO M. ; RANGEL L. SILVAA, CELINA M. LOTUFO ; VERRI, WALDICEU A. ; FUNEZ, MANI I. ; VILLARREAL, CHRISTIANE F. ; TALBOT, JHIMMY ; SOUSA, LIRLANDIA P. ; PARADA, CARLOS A. ; CUNHA, FERNANDO Q. ; FERREIRA, SERGIO H. . Involvement of Nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception. Pharmacology, Biochemistry and Behavior , v. 19, p. 1, 2015.
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QUINTANS, JULLYANA ; BARRETO, ROSANA ; DE LUCCA, WALDECY ; VILLARREAL, CRISTIANE ; KANETO, CARLA ; SOARES, MILENA ; BRANCO, ALEXSANDRO ; ALMEIDA, JACKSON ; TARANTO, ALEX ; ANTONIOLLI, ANGELO ; FREITAS, RIVELILSON ; QUINTANS-JÚNIOR, LUCINDO . Evidence for the Involvement of Spinal Cord-Inhibitory and Cytokines-Modulatory Mechanisms in the Anti-Hyperalgesic Effect of Hecogenin Acetate, a Steroidal Sapogenin-Acetylated, in Mice. Molecules (Basel. Online) , v. 19, p. 8303-8316, 2014.
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LIMA, M. S. ; EVANGELISTA, A. F. ; Santos, G.G.L. ; RIBEIRO, I. M. ; TOMASSINI, T. C. B. ; SOARES, M. B. P. ; VILLARREAL, C. F. . Antinociceptive Properties of Physalins from. Journal of Natural Products (Print) , v. 14, p. 141114114615000, 2014.
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MENDONCA, M. V. P. ; LAROCCA, T. F. ; SOUZA, B. S. ; VILLARREAL, C. F. ; SILVA, L. F. M. ; MATOS, A. C. ; NOVAES, M. A. ; BAHIA, C. M. P. ; MARTINEZ, A. C. ; KANETO, C. M. ; SOARES, M. B. P. ; SANTOS, R. R. . Safety And Neurological Assessments After Autologous Transplantation Of Bone Marrow Mesenchymal Stem Cells In Subjects With Chronic Spinal Cord Injury. Stem Cell Research & Therapy , v. 5, p. 126, 2014.
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Guimarães, E.T. ; CRUZ, G. ; ALMEIDA, T. F. ; SOLANO, B. ; KANETO, C. M. ; VASCONCELOS, J. F. ; Santos, Ricardo Ribeiro dos ; Villarreal, CF ; Soares, Milena Botelho Pereira . Transplantation of Stem Cells Obtained From Murine Dental Pulp Improves Pancreatic Damage, Renal Function, and Painful Diabetic Neuropathy in Diabetic Type 1 Mouse Model. CELL TRANSPLANTATION , v. 22, p. 2345-2354, 2013.
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GAMA, K. B. ; QUINTANS, J. S.S ; ANTONIOLLI, A. R. ; QUINTAS-JUNIOR, L. J. ; SANTANA, W. A. ; BRANCO, A. ; SOARES, M. B. P. ; VILLARREAL, C. F. . Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate. Journal of Natural Products (Print) , p. 130225100857009, 2013.
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LIMA, MILENA DA SILVA ; QUINTANS-JÚNIOR, LUCINDO J. ; DE SANTANA, WAGNO ALCÂNTARA ; MARTINS KANETO, CARLA ; Pereira Soares, Milena Botelho ; Villarreal, Cristiane Flora . Anti-inflammatory effects of carvacrol: Evidence for a key role of interleukin-10. EUROPEAN JOURNAL OF PHARMACOLOGY , v. 699, p. 112-117, 2013.
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LIMA, F.O. ; ALVES, V. ; BARBOSA FILHO, J. M. ; Almeida, J R G S ; RODRIGUES, L. C. ; SOARES, M. B. P. ; Villarreal, CF . Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition. PTR. Phytotherapy Research , v. 27, p. 1557-1563, 2013.
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Villarreal, Cristiane Flora ; Funez, Mani Indiana ; CUNHA, FERNANDO DE QUEIROZ ; Parada, Carlos Amílcar ; Ferreira, Sérgio Henrique . The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR , v. 103, p. 678-683, 2013.
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Alves C Q ; David, Jorge M. ; David, Juceni P. ; Villarreal, CF ; SOARES, M. B. P. ; Queiroz, LP ; Aguiar, RM . FLAVONOIDS AND OTHER BIOACTIVE PHENOLICS ISOLATED FROM Cenostigma macrophyllum (LEGUMINOSAE). Química Nova (Impresso) , v. 35, p. 1137-1140, 2012.
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Santos, G.G.L. ; Silva, L L C ; SOARES, M. B. P. ; VILLARREAL, C. F. . Antinociceptive properties of Micrurus lemniscatus venom. Toxicon (Oxford) , v. 60, p. 1005-1012, 2012.
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Nonato, Fabiana Regina ; SANTANA, DANIELLE GOMES ; DE MELO, FLAVIELLE MARTINS ; DOS SANTOS, GISELE GRAÇA LEITE ; BRUSTOLIM, DANIELLE ; CAMARGO, ENILTON A. ; DE SOUSA, DAMIÃO P. ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora . Anti-inflammatory properties of rose oxide. International Immunopharmacology (Print) , v. 14, p. 779-784, 2012.
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de Lima, Fla?via Oliveira ; Nonato, Fabiana Regina ; Couto, Ricardo David ; Barbosa Filho, Jose? Maria ; Nunes, Xirley Pereira ; Ribeiro dos Santos, Ricardo ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora . Mechanisms Involved in the Antinociceptive Effects of 7-Hydroxycoumarin. Journal of Natural Products (Print) , p. 110318135324064, 2011.
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Nonato, Fabiana Regina ; Nogueira, Tâmara Magalhães Oliveira ; de Almeida Barros, Taís Adelita ; Lucchese, Angélica Maria ; Oliveira, Carlos Eduardo Cordeiro ; Santos, Ricardo Ribeiro dos ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora . Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1? inhibition. Journal of Ethnopharmacology , v. 136, p. 518-524, 2011.
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de Oliveira, Cristiane Metzker ; Nonato, Fabiana Regina ; de Lima, Flávia Oliveira ; Couto, Ricardo David ; David, Juceni P. ; David, Jorge M. ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora . Antinociceptive Properties of Bergenin. Journal of Natural Products (Print) , v. 74, p. 2062-2068, 2011.
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De Almeida Barros, Taís A. ; De Freitas, Luis A.R. ; Filho, José M.B. ; Nunes, Xirley P. ; Giulietti, Ana M. ; De Souza, Glória E. ; Dos Santos, Ricardo R. ; Soares, Milena B.P. ; Villarreal, Cristiane F. . Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain. Journal of Pharmacy and Pharmacology , v. 62, p. 205-213, 2010.
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SACHS, D ; VILLARREAL, C. F. ; Cunha, FQ ; Parada, CA ; Ferreira, SH . The role of PKA and PKC pathways in prostaglandin E2-mediated hypernociception. British Journal of Pharmacology , v. 156, p. 826-834, 2009.
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Villarreal, Cristiane Flora ; Sachs, Daniela ; Funez, Mani Indiana ; Parada, Carlos Amílcar ; de Queiroz Cunha, Fernando ; Ferreira, Sérgio Henrique . The peripheral pro-nociceptive state induced by repetitive inflammatory stimuli involves continuous activation of protein kinase A and protein kinase C epsilon and its NaV1.8 sodium channel functional regulation in the primary sensory neuron. BIOCHEMICAL PHARMACOLOGY , v. 77, p. 867-877, 2009.
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Nonato, Fabiana Regina ; Barros, Tais Adelita Almeida ; Lucchese, Angélica Maria ; Oliveira, Carlos Eduardo Cordeiro ; Santos, Ricardo Ribeiro dos ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora . Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract. Journal of Ethnopharmacology , v. 125, p. 102-107, 2009.
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VILLARREAL, C. F. ; Funez MI ; Cunha FQ ; Parada CA ; Ferreira SH . Acute and persistent nociceptive paw sensitisation in mice: The involvement of distinct signalling pathways. Life Sciences (1973) , v. 85, p. 822-829, 2009.
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Villarreal, Cristiane Flora ; Prado, Wiliam Alves . Modulation of persistent nociceptive inputs in the anterior pretectal nucleus of the rat. PAIN , v. 132, p. 42-52, 2007.
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VILLARREAL, C ; SACHS, D ; DEQUEIROZCUNHA, F ; PARADA, C ; FERREIRA, S ; VILLARREAL, C. F. . The role of Na1.8 sodium channel in the maintenance of chronic inflammatory hypernociception. NEUROSCIENCE LETTERS , USA, v. 386, n.2, p. 72-77, 2005.
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Kina, Vania Aparecida V. ; VILLARREAL, C. F. ; Prado, Wiliam A. . The effects of intraspinal L-NOARG or SIN-1 on the control by descending pathways of incisional pain in rats. Life Sciences , USA, v. 76, n.17, p. 1939-1951, 2005.
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VILLARREAL, C. F. ; Kina, Vania Aparecida V ; Prado, Wiliam Alves . Participation of brainstem nuclei in the pronociceptive effect of lesion or neural block of the anterior pretectal nucleus in a rat model of incisional pain. Neuropharmacology , USA, v. 47, n.1, p. 117-127, 2004.
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VILLARREAL, C. F. ; Kina, Vania Aparecida V ; Prado, Wiliam A . Antinociception induced by stimulating the anterior pretectal nucleus in two models of pain in rats. Clinical and Experimental Pharmacology & Physiology , USA, v. 31, n.9, p. 608-613, 2004.
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VILLARREAL, C. F. ; Del Bel E A ; PRADO, W. A. . Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat. PAIN , Estados Unidos, v. 103, p. 163-174, 2003.