Elizabeth Shephard

Pós-doutorado

Formação complementar

Idiomas

Áreas de atuação

Participação em eventos

Orientou

Produções bibliográficas

• MILLER, MEGHAN ; ARNETT, ANNE B. ; SHEPHARD, ELIZABETH ; CHARMAN, TONY ; GUSTAFSSON, HANNA C. ; JOSEPH, HEATHER M. ; KARALUNAS, SARAH ; NIGG, JOEL T. ; POLANCZYK, GUILHERME V. ; SULLIVAN, ELINOR L. ; JONES, EMILY J. H. . Delineating early developmental pathways to ADHD: Setting an international research agenda. JCPP Advances , v. 3, p. e12144-e12144, 2023.

• TYE, CHARLOTTE ; MCEWEN, FIONA S. ; LIANG, HOLAN ; WOODHOUSE, EMMA ; UNDERWOOD, LISA ; SHEPHARD, ELIZABETH ; BARKER, EDWARD D. ; SHEERIN, FINTAN ; HIGGINS, NICHOLAS ; STEENBRUGGEN, JUUL ; BOLTON, PATRICK F. . Epilepsy severity mediates association between mutation type and ADHD symptoms in tuberous sclerosis complex. EPILEPSIA , v. 64, p. 30-35, 2023.

• BRANDI GOMES GODOY, PRISCILLA ; MCWILLIAMS, LORNA ; RODRIGUES DA SILVEIRA, LETICIA ; DE CESARO REVERS BIASÃO, MIRIAN ; SPEGGIORIN PEREIRA ALARCÃO, FERNANDA ; SEDA, LEONARDO ; GENEROSO CAMPOLI, RENATA ; LIANG, HOLAN ; DIVAN, GAURI ; LEADBITTER, KATHY ; GREEN, JONATHAN ; SHEPHARD, ELIZABETH . Acceptability and feasibility of a parent-mediated social-communication therapy for young autistic children in Brazil: A qualitative implementation study of Paediatric Autism Communication Therapy. AUTISM , p. 136236132211445, 2023.

• BELLATO, ALESSIO ; ADMANI, MUSKAAN ALEEZA ; DEAK, CAMILA ; FARHAT, LUIS CARLOS ; FONTANA ANTUNES DE OLIVEIRA, MARIA CAROLINA ; VASCONCELOS, REBECA ; MALANCHINI, MARGHERITA ; SHEPHARD, ELIZABETH ; MICHELINI, GIORGIA . Autonomic dysregulation and self-injurious thoughts and behaviours in children and young people: A systematic review and meta-analysis. JCPP Advances , v. 3, p. e12148-e12148, 2023.

• SHEPHARD, ELIZABETH ; MCEWEN, FIONA S. ; EARNEST, THOMAS ; FRIEDRICH, NINA ; MÖRTL, ISABELLE ; LIANG, HOLAN ; WOODHOUSE, EMMA ; TYE, CHARLOTTE ; BOLTON, PATRICK F. . Oscillatory neural network alterations in young people with tuberous sclerosis complex and associations with co-occurring symptoms of autism spectrum disorder and attention-deficit/hyperactivity disorder. CORTEX , v. 146, p. 50-65, 2022.

• VANES, LUCY D. ; TYE, CHARLOTTE ; TOURNIER, JACQUES-DONALD ; COMBES, ANNA J.E. ; SHEPHARD, ELIZABETH ; LIANG, HOLAN ; BARKER, GARETH J. ; NOSARTI, CHIARA ; BOLTON, PATRICK . White matter disruptions related to inattention and autism spectrum symptoms in tuberous sclerosis complex. NeuroImage-Clinical , v. 36, p. 103163, 2022.

• FARHAT, LUIS C. ; BRENTANI, HELENA ; DE TOLEDO, VICTOR HUGO CALEGARI ; SHEPHARD, ELIZABETH ; MATTOS, PAULO ; BARON'COHEN, SIMON ; THAPAR, ANITA ; CASELLA, ERASMO ; POLANCZYK, GUILHERME V. . ADHD and autism symptoms in youth: a network analysis. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY , v. 63, p. 143-151, 2022.

• DAMIANO, RODOLFO FURLAN ; MIGUEL, EURIPEDES CONSTANTINO ; SHEPHARD, ELIZABETH . Not only pharmacodynamic: the role of brain circuits in improving the treatment of suicidal thoughts and behaviors. REVISTA BRASILEIRA DE PSIQUIATRIA , v. 44, p. 113-113, 2022.

• SHEPHARD, ELIZABETH ; STERN, EMILY R. ; MIGUEL, EURÍPEDES C. . Obsessive-Compulsive Disorder Treatment Based on Neurocircuits. PSYCHIATRIC ANNALS , v. 52, p. 152-156, 2022.

• SHEPHARD, ELIZABETH ; STERN, EMILY R. ; VAN DEN HEUVEL, ODILE A. ; COSTA, DANIEL L. C. ; BATISTUZZO, MARCELO C. ; GODOY, PRISCILLA B. G. ; LOPES, ANTONIO C. ; BRUNONI, ANDRE R. ; HOEXTER, MARCELO Q. ; SHAVITT, ROSELI G. ; JANARDHAN REDDY, Y. C. ; LOCHNER, CHRISTINE ; STEIN, DAN J. ; SIMPSON, H. BLAIR ; MIGUEL, EURIPEDES C. . Expanding the heuristic neurocircuit-based taxonomy to guide treatment for OCD: reply to the commentary -Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder-. MOLECULAR PSYCHIATRY , v. 27, p. 3560-3561, 2022.

• GODOY, PRISCILLA BRANDI GOMES ; SUMIYA, FERNANDO MITSUO ; SEDA, LEONARDO ; SHEPHARD, ELIZABETH . A systematic review of observational, naturalistic, and neurophysiological outcome measures of nonpharmacological interventions for autism. REVISTA BRASILEIRA DE PSIQUIATRIA , v. 44, p. 5, 2022.

• ZHANG, ALEXA X. D. ; LIANG, HOLAN ; MCEWEN, FIONA S. ; TYE, CHARLOTTE ; WOODHOUSE, EMMA ; UNDERWOOD, LISA ; SHEPHARD, ELIZABETH ; SHEERIN, FINTAN ; BOLTON, PATRICK F. . Perinatal adversities in tuberous sclerosis complex: Determinants and neurodevelopmental outcomes. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY , v. 64, p. 1237-1245, 2022.

• SILVEIRA, JULIA BELIZÁRIO ; DAMIANO, RODOLFO FURLAN ; ABELAMA NETO, EMILIO ; GOMES, RAPHAEL NEVES DOS SANTOS MOSQUEIRA ; KLEIN, IZIO ; BORRIONE, LUCAS ; SUDBRACK, PEDRO ; GENTIL, ANDRÉ FELIX ; SHEPHARD, ELIZABETH ; BRUNONI, ANDRÉ RUSSOWSKI ; MIGUEL, EURÍPEDES CONSTANTINO ; ECHEVARRIA, MARCO ANTONIO NOCITO . Double cone coil repetitive transcranial magnetic stimulation for severe obsessive-compulsive disorder after reversible cerebral vasoconstriction syndrome with intracerebral hemorrhage: a case report. REVISTA BRASILEIRA DE PSIQUIATRIA , v. 44, p. 562-564, 2022.

• OLIVEIRA, JORDANA VERANO DE ; FATORI, DANIEL ; SHEPHARD, ELIZABETH ; XAVIER NETO, MAURO ; MATIJASEVICH, ALICIA ; FERRARO, ALEXANDRE ARCHANJO ; ROHDE, LUIS AUGUSTO ; CHIESA, ANNA MARIA ; MIGUEL, EURIPEDES CONSTANTINO ; POLANCZYK, GUILHERME V. . Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life. REVISTA BRASILEIRA DE PSIQUIATRIA , v. 44, p. 388-400, 2022.

• ZUCCOLO, PEDRO FONSECA ; CASELLA, CAIO BORBA ; FATORI, DANIEL ; SHEPHARD, ELIZABETH ; SUGAYA, LUISA ; GURGEL, WAGNER ; FARHAT, LUIS CARLOS ; ARGEU, ADRIANA ; TEIXEIRA, MONIKE ; OTOCH, LUARA ; POLANCZYK, GUILHERME V. . Children and adolescents' emotional problems during the COVID-19 pandemic in Brazil. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY , v. 32, p. 1083-1095, 2022.

• GODOY, PRISCILLA B. G. ; SHEPHARD, ELIZABETH ; ARGEU, ADRIANA ; SILVEIRA, LETICIA R. ; SALOMONE, ERICA ; ALDRED, CATHERINE ; GREEN, JONATHAN ; POLANCZYK, GUILHERME V. ; MATIJASEVICH, ALICIA . Social communication therapy for children at risk for neurodevelopmental difficulties: Protocol for a clinical trial. Annals of the New York Academy of Sciences , v. 1514, p. 104-115, 2022.

• SHEPHARD, ELIZABETH ; STERN, EMILY R. ; VAN DEN HEUVEL, ODILE A. ; COSTA, DANIEL L. C. ; BATISTUZZO, MARCELO C. ; GODOY, PRISCILLA B. G. ; LOPES, ANTONIO C. ; BRUNONI, ANDRE R. ; HOEXTER, MARCELO Q. ; SHAVITT, ROSELI G. ; REDDY, Y. C. JANARDHAN ; LOCHNER, CHRISTINE ; STEIN, DAN J. ; SIMPSON, H. BLAIR ; MIGUEL, EURIPEDES C. . Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder. MOLECULAR PSYCHIATRY , v. 26, p. 4583-4604, 2021.

• SHEPHARD, ELIZABETH ; BATISTUZZO, MARCELO C. ; HOEXTER, MARCELO Q. ; STERN, EMILY R. ; ZUCCOLO, PEDRO F. ; OGAWA, CAROLINA Y. ; SILVA, RENATA M. ; BRUNONI, ANDRE R. ; COSTA, DANIEL L. ; DORETTO, VICTORIA ; SARAIVA, LEONARDO ; CAPPI, CAROLINA ; SHAVITT, ROSELI G. ; SIMPSON, H. BLAIR ; VAN DEN HEUVEL, ODILE A. ; MIGUEL, EURIPEDES C. . Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research. REVISTA BRASILEIRA DE PSIQUIATRIA , v. 44, p. 187-200, 2021.

• GODOY, PRISCILLA B. G. ; SHEPHARD, ELIZABETH ; MILOSAVLJEVIC, BOSILJKA ; JOHNSON, MARK H. ; CHARMAN, TONY ; BARON-COHEN, SIMON ; BEDFORD, RACHAEL ; BOLTON, PATRICK F. ; CHANDLER, SUSIE ; ELSABBAGH, MAYADA ; FERNANDES, JANICE ; GARWOOD, HOLLY ; GLIGA, TEODORA ; HUDRY, KRISTELLE ; JONES, EMILY J. H. ; PASCO, GREG ; PICKLES, ANDREW ; TUCKER, LESLIE ; VOLEIN, AGNES . Brief Report: Associations Between Cognitive Control Processes and Traits of Autism Spectrum Disorder (ASD), attention-Deficit/Hyperactivity Disorder (ADHD) and Anxiety in Children at Elevated and Typical Familial Likelihood for ASD. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS , v. 51, p. 3001-3013, 2021.

• SHEPHARD, ELIZABETH ; ZUCCOLO, PEDRO F. ; IDREES, IMAN ; GODOY, PRISCILLA B.G. ; SALOMONE, ERICA ; FERRANTE, CAMILLA ; SORGATO, PAOLA ; CATÃO, LUÍS F.C.C. ; GOODWIN, AMY ; BOLTON, PATRICK F. ; TYE, CHARLOTTE ; GROOM, MADELEINE J. ; POLANCZYK, GUILHERME V. . Systematic Review and Meta-analysis: The Science of Early-Life Precursors and Interventions for Attention-Deficit/Hyperactivity Disorder. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY , v. 61, p. 187-226, 2021.

• ALARCÃO, FERNANDA SPEGGIORIN PEREIRA ; SHEPHARD, ELIZABETH ; FATORI, DANIEL ; AMÁVEL, RENATA ; CHIESA, ANNA ; FRACOLLI, LISLAINE ; MATIJASEVICH, ALICIA ; BRENTANI, HELENA ; NELSON, CHARLES A. ; LECKMAN, JAMES ; MIGUEL, EURÍPEDES CONSTANTINO ; POLANCZYK, GUILHERME V. . Promoting mother-infant relationships and underlying neural correlates: Results from a randomized controlled trial of a home¿visiting program for adolescent mothers in Brazil. DEVELOPMENTAL SCIENCE , v. 24, p. e13113, 2021.

• BELLATO, ALESSIO ; NORMAN, LUKE ; IDREES, IMAN ; OGAWA, CAROLINA Y. ; WAITT, ALICE ; ZUCCOLO, PEDRO F. ; TYE, CHARLOTTE ; RADUA, JOAQUIM ; GROOM, MADELEINE J. ; SHEPHARD, ELIZABETH . A systematic review and meta-analysis of altered electrophysiological markers of performance monitoring in Obsessive-Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (GTS), Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS , v. 131, p. 964-987, 2021.

• FATORI, DANIEL ; FONSECA ZUCCOLO, PEDRO ; SHEPHARD, ELIZABETH ; BRENTANI, HELENA ; MATIJASEVICH, ALICIA ; ARCHANJO FERRARO, ALEXANDRE ; APARECIDA FRACOLLI, LISLAINE ; CHIESA, ANNA MARIA ; LECKMAN, JAMES ; CONSTANTINO MIGUEL, EURIPEDES ; V. POLANCZYK, GUILHERME . A randomized controlled trial testing the efficacy of a Nurse Home Visiting Program for Pregnant Adolescents. Scientific Reports , v. 11, p. 14432-14432, 2021.

• SHEPHARD, ELIZABETH ; MILOSAVLJEVIC, BOSILJKA ; MASON, LUKE ; ELSABBAGH, MAYADA ; TYE, CHARLOTTE ; GLIGA, TEODORA ; JONES, EMILY JH. ; CHARMAN, TONY ; JOHNSON, MARK H. ; BARON-COHEN, SIMON ; BEDFORD, RACHAEL ; BOLTON, PATRICK ; CHANDLER, SUSIE ; FERNANDES, JANICE ; GARWOOD, HOLLY ; HUDRY, KRISTELLE ; PASCO, GREG ; PICKLES, ANDREW ; TUCKER, LESLIE ; VOLEIN, AGNES ; et.al . Neural and behavioural indices of face processing in siblings of children with autism spectrum disorder (ASD): A longitudinal study from infancy to mid-childhood. CORTEX , v. 127, p. 162-179, 2020.

• SILVEIRA, VITOR PORTELLA ; FRYDMAN, ILANA ; FONTENELLE, LEONARDO F. ; MATTOS, PAULO ; DE OLIVEIRA-SOUZA, RICARDO ; MOLL, JORGE ; HOEXTER, MARCELO QUEIROZ ; MIGUEL, EURÍPEDES CONSTANTINO ; MCLAUGHLIN, NICOLE C.R. ; SHEPHARD, ELIZABETH ; BATISTUZZO, MARCELO CAMARGO . Exploring response inhibition and error monitoring in obsessive-compulsive disorder. JOURNAL OF PSYCHIATRIC RESEARCH , v. 126, p. 26-33, 2020.

• GUI, ANNA ; MASON, LUKE ; GLIGA, TEODORA ; HENDRY, ALEXANDRA ; BEGUM ALI, JANNATH ; PASCO, GREG ; SHEPHARD, ELIZABETH ; CURTIS, CHARLES ; CHARMAN, TONY ; JOHNSON, MARK H. ; MEABURN, EMMA ; JONES, EMILY J. H. . Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD. DEVELOPMENT AND PSYCHOPATHOLOGY , v. 32, p. 1303-1322, 2020.

• EARNEST, TOM ; SHEPHARD, ELIZABETH ; TYE, CHARLOTTE ; MCEWEN, FIONA ; WOODHOUSE, EMMA ; LIANG, HOLAN ; SHEERIN, FINTAN ; BOLTON, PATRICK F. . Actigraph-Measured Movement Correlates of Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms in Young People with Tuberous Sclerosis Complex (TSC) with and without Intellectual Disability and Autism Spectrum Disorder (ASD). BRAIN SCIENCES , v. 10, p. 491, 2020.

• SHEPHARD, ELIZABETH ; TYE, CHARLOTTE ; ASHWOOD, KAREN L. ; AZADI, BAHAR ; JOHNSON, MARK H. ; CHARMAN, TONY ; ASHERSON, PHILIP ; MCLOUGHLIN, GRAINNE ; BOLTON, PATRICK F. . Oscillatory neural networks underlying resting-state, attentional control and social cognition task conditions in children with ASD, ADHD and ASD+ADHD. CORTEX , v. 117, p. 96-110, 2019.

• SHEPHARD, ELIZABETH ; FATORI, DANIEL ; MAURO, LARISSA REZENDE ; DE MEDEIROS FILHO, MAURO V. ; HOEXTER, MARCELO Q. ; CHIESA, ANNA M. ; FRACOLLI, LISLAINE A. ; BRENTANI, HELENA ; FERRARO, ALEXANDRE A. ; NELSON, CHARLES A. ; MIGUEL, EURIPEDES C. ; POLANCYK, GUILHERME V. . Effects of maternal psychopathology and education level on neurocognitive development in infants of adolescent mothers living in poverty in Brazil. BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING , v. 4, p. 925-934, 2019.

• OZONOFF, SALLY ; YOUNG, GREGORY S. ; BRIAN, JESSICA ; CHARMAN, TONY ; SHEPHARD, ELIZABETH ; SOLISH, ABBIE ; ZWAIGENBAUM, LONNIE . Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY , v. 57, p. 849-857.e2, 2018.

• SALOMONE, ERICA ; SHEPHARD, ELIZABETH ; MILOSAVLJEVIC, BOSILJKA ; JOHNSON, MARK H. ; CHARMAN, TONY . Adaptive Behaviour and Cognitive Skills: Stability and Change from 7 Months to 7 Years in Siblings at High Familial Risk of Autism Spectrum Disorder. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS , v. 48, p. 2901-2911, 2018.

• SHEPHARD, ELIZABETH ; GROOM, MADELEINE J. ; JACKSON, GEORGINA M. . Implicit sequence learning in young people with Tourette syndrome with and without co-occurring attention-deficit/hyperactivity disorder. Journal of Neuropsychology , v. 13, p. 1, 2018.

• SHEPHARD, ELIZABETH ; BEDFORD, RACHAEL ; MILOSAVLJEVIC, BOSILJKA ; GLIGA, TEODORA ; JONES, EMILY J.H. ; PICKLES, ANDREW ; JOHNSON, MARK H. ; CHARMAN, TONY . Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY , v. 60, p. 1, 2018.

• SHEPHARD, ELIZABETH ; TYE, CHARLOTTE ; ASHWOOD, KAREN L. ; AZADI, BAHAR ; ASHERSON, PHILIP ; BOLTON, PATRICK F. ; MCLOUGHLIN, GRAINNE . Resting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD-+-ADHD. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS , v. 48, p. 110-122, 2018.

• SHEPHARD, ELIZABETH ; MILOSAVLJEVIC, BOSILJKA ; PASCO, GREG ; JONES, EMILY J. H. ; GLIGA, TEODORA ; HAPPÉ, FRANCESCA ; JOHNSON, MARK H. ; CHARMAN, TONY . Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder. Autism Research , v. 10, p. 546-557, 2017.

• BEDFORD, RACHAEL ; GLIGA, TEODORA ; SHEPHARD, ELIZABETH ; ELSABBAGH, MAYADA ; PICKLES, ANDREW ; CHARMAN, TONY ; JOHNSON, MARK H. . Neurocognitive and observational markers: prediction of autism spectrum disorder from infancy to mid-childhood. Molecular Autism , v. 8, p. 49, 2017.

• MILOSAVLJEVIC, BOSILJKA ; SHEPHARD, ELIZABETH ; HAPPÉ, FRANCESCA G. ; JOHNSON, MARK H. ; CHARMAN, TONY . Anxiety and Attentional Bias to Threat in Children at Increased Familial Risk for Autism Spectrum Disorder. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS , v. 47, p. 3714-3727, 2017.

• SHEPHARD, ELIZABETH ; JACKSON, GEORGINA M. ; GROOM, MADELEINE J. . The effects of co-occurring ADHD symptoms on electrophysiological correlates of cognitive control in young people with Tourette syndrome. Journal of Neuropsychology , v. 10, p. 223-238, 2016.

• SHEPHARD, E. ; JACKSON, G.M. ; GROOM, M.J. . Learning and altering behaviours by reinforcement: Neurocognitive differences between children and adults. Developmental Cognitive Neuroscience , v. 7, p. 94-105, 2014.

• BENSON, PHILIP J. ; BEEDIE, SARA A. ; SHEPHARD, ELIZABETH ; GIEGLING, INA ; RUJESCU, DAN ; ST. CLAIR, DAVID . Simple Viewing Tests Can Detect Eye Movement Abnormalities That Distinguish Schizophrenia Cases from Controls with Exceptional Accuracy. BIOLOGICAL PSYCHIATRY , v. 72, p. 716-724, 2012.

• SHEPHARD, E. ; GROOM, MADELEINE J. ; Jackson, GM . Co-occurring ADHD symptoms and electrophysiological correlates of cognitive control in Tourette syndrome. In: Marc E. Lavoie, Andrea E. Cavanna. (Org.). The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics. 3ed.: , 2022, v. 3, p. 1-441.

Projetos de pesquisa

• 2021 - Atual

  Efeitos de fatores biológicos e ambientais e intervenção psicossocial nas vias neurodesenvolvimentais precoces em crianças vulneráveis, Descrição: O transtorno do espectro do autismo (TEA) e o transtorno do déficit de atenção/hiperatividade (TDAH) são condições comuns e prejudiciais ao neurodesenvolvimento. A identificação precoce de bebês em risco de desenvolver TEA e/ou TDAH e o uso de intervenções preventivas para limitar o surgimento e o impacto dos sintomas são estratégias preventivas importantes para reduzir o impacto desses transtornos. O principal objetivo deste projeto de Jovem Pesquisador é estabelecer o primeiro estudo longitudinal prospectivo de bebês em risco familiar para TEA e TDAH em um contexto de país de baixa e média renda (LMIC - Brasil). O estudo investigará como o risco familiar de TEA e TDAH afeta trajetórias precoces de neurodesenvolvimento em bebês que vivem em um LMIC, como as alterações nas trajetórias precoces de neurodesenvolvimento se relacionam com o surgimento de TEA e TDAH posteriormente no desenvolvimento, e se fatores de risco biológicos (inflamação, função do sistema de resposta ao estresse) e ambientais (pobreza, trauma na infância, estresse materno) mediam os efeitos negativos do risco familiar de TEA e TDAH nas vias neurodesenvolvimentais precoces. Os resultados deste projeto farão uma contribuição significativa para a literatura existente de países de alta renda (HICs) sobre como o risco familiar de TEA e TDAH afeta o desenvolvimento infantil e a generalização de descobertas anteriores para bebês que crescem em ambientes desfavorecidos. Os resultados também fornecerão novas evidências cruciais relação à eficácia da intervenção psicossocial preventiva para bebês vulneráveis em LMICs, que atualmente é uma prioridade global.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Elizabeth Shephard - Coordenador.

• 2020 - 2021

  Entendendo o processamento emocional no TDAH: a análise de dados eletrofisiológicos empíricos em pré-escolares, Descrição: A regulação emocional corresponde à capacidade de o indivíduo, por uma série de mecanismos, modular as respostas emocionalmente evocadas pelos mais diversos estímulos de forma a controlar e eventualmente alterar seu estado emocional conforme a situação, oferecendo possibilidades adaptativas do comportamento bastante importantes na vida social dos indivíduos e na conquista de seus objetivos. Esses mecanismos, conforme sugerido por uma série de evidências, estão de alguma forma alterados em transtornos do neurodesenvolvimento, com destaque para o TDAH (Transtorno do Déficit de Atenção com Hiperatividade). O presente estudo visa a propor uma análise dos correlatos eletrofisiológicos, especificamente os ERPs (potenciais relacionados a eventos), do processamento emocional em crianças pré-escolares com TDAH. Esse projeto irá contribuir significativamente para o campo dos estudos em neurodesenvolvimento por fornecer novas informações sobre os mecanismos neurais subjacentes aos problemas de regulação emocional em jovens crianças diagnosticadas com TDAH.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Elizabeth Shephard - Coordenador / Guilherme V Polanczyk - Integrante / Luís Felipe Chagas Caldeira Catão - Integrante.

• 2019 - 2021

  A multimodal neuroimaging investigation of changes in neural circuitry during early interventions for neurodevelopmental disorders, Descrição: The objective of this fellowship project is to design and implement longitudinal multimodal neuroimaging methods for investigating changes in neural circuitry in infants and young children that are associated with early interventions for neurodevelopmental disorders (NDs). Brain activity will be assessed using two neuroimaging techniques, electroencephalography (EEG) and functional near infra-red spectroscopy (fNIRS), to measure brain circuits on complementary spatiotemporal scales. Neuroimaging data will be collected in a prospective longitudinal design with assessments conducted pre- and post- early interventions. These methods will be employed across three randomised controlled trials (RCTs) of early interventions for different neurodevelopmental problems (autism spectrum disorder, attention-deficit/hyperactivity disorder, and infants of adolescent mothers living in poverty). Across all three interventions, graph-theoretical and longitudinal statistical analysis methods will be used to compute and analyse pre- vs. post-intervention changes in neural circuitry of the participating infants and young children and assess how those changes relate to improvements in children?s cognition, behaviour and symptoms of NDs. The results of this project will yield novel information about the neurobiological effects of currently available early interventions for a range of neurodevelopmental problems, which could be used to promote the use of specific interventions and in supporting public policies for early intervention use in vulnerable populations.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) / Mestrado acadêmico: (2) / Doutorado: (1) . , Integrantes: Elizabeth Shephard - Coordenador / Guilherme V Polanczyk - Integrante., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Bolsa.

• 2018 - 2021

  Associations between maternal risk-factors, infant cognition and behavior, and infant neurophysiological activity in infants of adolescent mothers living in a poor region of São Paulo, Brazil, Descrição: Adolescent motherhood remains common in developing countries and is associated with a range of risk factors that adversely impact infant neurocognitive development, including socio-economic depravation, low maternal education, and increased maternal psychiatric problems. Yet, few empirical studies have examined neurocognitive functioning in infants born to adolescent mothers, and no published work has used neuroimaging or neurophysiology to directly assess how risk factors associated with adolescent motherhood in developing countries affect early-life brain development. Understanding precisely how brain development is affected in infants of adolescent mothers and which specific maternal risk-factors brain alterations relate to will be crucial in designing targeted and effective interventions to prevent impaired neurocognitive development in these infants. In this study, we are examining associations between maternal risk-factors (education level and symptoms of anxiety, depression and ADHD) and indices of infant neurocognitive development (oscillatory power and functional connectivity obtained from resting-state EEG, cognitive and language ability, temperament) in a sample (n = 50) of adolescent mothers and their infants living in an impoverished area of São Paulo, Brazil.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Elizabeth Shephard - Coordenador / Euripedes C Miguel - Integrante / Guilherme V Polanczyk - Integrante / Daniel Fatori - Integrante / Anna M Chiesa - Integrante / Helena Brentani - Integrante / Lislaine Fracolli - Integrante / Alexandre Ferraro - Integrante.

• 2018 - 2019

  The effects of psychosocial risks/intervention and neuropsychiatric symptoms on social functioning and neural networks in Brazilian infants, children, and young people, Descrição: The proposed visiting researcher grant will support research activities of Dr Elizabeth Shephard from the Institute of Psychiatry, Psychology, & Neuroscience, King?s College London, to be conducted at the Department of Psychiatry, University of São Paulo with the host Professor Euripedes Constantino Miguel. Dr Shephard has expertise in using cognitive neuroscience techniques to study neural and cognitive mechanisms involved in neurodevelopmental disorders, and in mapping risk pathways to neurodevelopmental disorders via longitudinal studies of children with familial or genetic risk. During the 12 months (26/02/2018 ? 25/02/2019) of the grant, Dr Shephard will analyse data from FAPESP-funded projects, including the National Institute for Developmental Psychiatry (INDP-II), applying her techniques to address three related questions about neurodevelopment in Brazilian infants, children, and young people: 1) Which cognitive factors mediate the relationship between exposure to family violence and conflict and the development of children?s social functioning? 2) How is the developmental trajectory of infant neurocognitive risk-markers for attention-deficit/hyperactivity disorder influenced by socioeconomic depravation and parenting intervention? 3) Can abnormalities in neural habituation and hyperconnectivity explain some of the symptoms of obsessive-compulsive disorder? Dr Shephard?s visit is in line with one of the key goals of the USP Department of Psychiatry and the INDP-II ? to increase internationalisation of developmental psychiatry research in São Paulo by exchange of researchers with other leading institutions around the world. In addition to providing analytical support to the research projects, she will give lectures and workshops in using neurophysiology to understand neuropsychiatric disorders, and participate in the Obsessive-Compulsive Disorders Program (PROTOC) at USP, assisting with the development of new research proposals.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Elizabeth Shephard - Coordenador / Euripedes C Miguel - Integrante., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Bolsa.

• 2018 - Atual

  Electrophysiological correlates of symptom improvement with deep brain stimulation treatment in OCD, Descrição: Deep brain stimulation (DBS) is an effective treatment option for ~60% of individuals with refractory obsessive-compulsive disorder (OCD). Still, precisely how DBS changes brain function and how those changes lead to improvements (or non-improvements) in symptoms are not fully understood. In this project, we aim to address this issue by longitudinally examining gradual changes in both neural activity and OCD symptoms over a 1-year pre-to-post-surgery period in patients with refractory OCD undergoing DBS treatment. We aim to identify 1) electrophysiological correlates of symptom improvement that could be investigated in future as targets for non-invasive (TMS/tDCS) brain stimulation treatments, and 2) pre-surgery neural characteristics that differentiate DBS responders from non-responders.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Elizabeth Shephard - Coordenador / Marcelo Q Hoexter - Integrante / Antonio C Lopes - Integrante / Euripedes C Miguel - Integrante.

• 2015 - 2018

  Electroencephalographic markers of neural network abnormalities underlying risk for autism spectrum disorders and attention deficit hyperactivity disorder, Descrição: This project seeks to characterise the nature of aberrant brain connectivity in ASD, ADHD and ASD+ADHD using methodologically rigorous state-of-the-art approaches and a novel research design that compares findings from cases of ASD, ADHD and ASD+ADHD with and without a specific genetic disorder (Tuberous Sclerosis) in two existing, well-characterised samples. We will examine the relationship between connectivity measures and other well-established neurophysiological and cognitive markers of ASD, ADHD and ASD+ADHD compared to controls. Together, the findings will elucidate the nature and specificity of abnormalities in brain circuitry in ASD, ADHD and ASD+ADHD.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) / Mestrado acadêmico: (3) . , Integrantes: Elizabeth Shephard - Coordenador / Patrick F Bolton - Integrante / Charlotte Tye - Integrante / Tony Charman - Integrante / Mark H Johnson - Integrante / Philip Asherson - Integrante / Grainne McLoughlin - Integrante.

• 2013 - 2016

  British Autism Study of Infant Siblings - 7-year follow-up (BASIS-7), Descrição: In this project, we conducted a 7-year longitudinal follow-up of a cohort of infants at high familial risk for ASD seen previously by our group at ages 6 months to 3 years. At age 7 years, we re-examined symptoms of ASD and aspects of brain and behavioural functioning that were associated with high-risk status and ASD/atypical developmental outcome at 3 years. The aims were to investigate a) the stability of symptoms (and diagnoses) of ASD across childhood, and b) the longer-term developmental trajectory of neurocognitive characteristics associated with ASD or high-risk status and how these relate to mid-childhood developmental outcome. Furthermore, we examined whether the clinical and neurocognitive measures obtained in infancy and toddlerhood could predict developmental outcome (e.g. diagnosis of ASD) and neurocognitive functioning in mid-childhood. http://www.basisnetwork.org/. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Elizabeth Shephard - Coordenador / Tony Charman - Integrante / Mark H Johnson - Integrante / Emily JH Jones - Integrante / Bosiljka Milosavljevic - Integrante / Francesca Happe - Integrante.

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