Michel Koole

Graduated as a master in Physics and trained as a Certified Medical Radiation Physicist, Michel Koole finished his PhD in 2002 at the University of Ghent (Belgium) with a doctoral thesis on quantitative SPECT imaging of the brain. After a postdoctoral fellowship, he worked for private software companies developing medical image analysis software, such as Hermes Medical Solutions and Agfa Healthcare. In 2007, he joined the Nuclear Medicine Department of UZ Gasthuisberg Leuven (Belgium), first as a medical physicist for the PET data analysis of contract research studies and at a later stage, as a research expert in quantitative molecular imaging. Mid 2012, he joined the medical physics team of the Nuclear Medicine and Molecular Imaging Department of the University Medical Center Groningen (the Netherlands), to strengthen research efforts in medical physics. Since October 2014, he has been appointed as Associate Professor at the KU Leuven (Belgium). Research interests mainly focus on translational aspects of PET imaging and quantitative hybrid PET/CT and PET/MRI imaging, in particular PET kinetic modelling, univariate and multivariate analysis of brain PET/MR imaging and multi-parametric lesion detection, segmentation and classification. He is also engaged in several (MR)PET-studies with leading pharmaceutical companies to support new drug development.

Informações coletadas do Lattes em 28/10/2024

Acadêmico

Formação acadêmica

Doutorado em Applied Sciences

1997 - 2002

Ghent University
Título: Quantitative SPECT imaging of the brain
Orientador: Stefaan Vandenberghe

Mestrado em Biomedical and Clinical Engineering

1995 - 1997

Ghent University
Título: Evaluatie en klinische implementatie van commerciële beeldfusiesoftware,Ano de Obtenção: 1997
Orientador: Stefaan Vandenberghe

Graduação em Physics

1992 - 1995

Ghent University

Pós-doutorado

2002 - 2003

Pós-Doutorado. , Ghent University, UGENT, Bélgica. , Grande área: Ciências da Saúde

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Francês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Holandês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Áreas de atuação

Grande área: Ciências da Saúde / Área: Medicina / Subárea: Nuclear Medicine.

Orientou

Masoomeh Rahimpour

Hybrid PET/MRI for improved tumor grading and detection of recurrent/residual disease in Neuro-Oncology; Início: 2018; Tese (Doutorado em Biomedical Sciences) - Katholieke Universiteit Leuven; (Orientador);

Nathalie Mertens

Synaptic density, tau and multiparametric PET-MR for quantitative functional assessment and prognosis in stroke and mild cognitive impairment; Início: 2018; Tese (Doutorado em Biomedical Sciences) - Katholieke Universiteit Leuven, Fonds Wetenschappelijk Onderzoek - Vlaanderen; (Orientador);

Martijn Devrome

Multimodal view on brain connectivity with simultaneous PET/MR; Início: 2017; Tese (Doutorado em Biomedical Sciences) - Katholieke Universiteit Leuven, Fonds Wetenschappelijk Onderzoek - Vlaanderen; (Orientador);

Paulo Rauli Rafeson Vasconcelos Caribé

Evaluation of image quality and reconstruction parameters in recent PET-CT and PET-MR system; 2020; Tese (Doutorado em Biomedical Engineering) - Ghent University, Conselho Nacional de Desenvolvimento Científico e Tecnológico; Orientador: Michel Koole;

Monique du Toit

A complex adaptive systems approach to whole body PET/CT imaging to improve tumor detection and tumor delineation; 2018; Tese (Doutorado em Medical Sciences) - University Medical Center Groningen, Abel Tasman talent program; Coorientador: Michel Koole;

Mingzan Zhuang

PET metrics for assessment of response to treatment and prediction of outcome; 2018; Tese (Doutorado em Medical Sciences) - University Medical Center Groningen, Abel Tasman talent program; Coorientador: Michel Koole;

Isadora Lopes Alves

Challenges and opportunities in quantitative brain PET imaging; 2017; Tese (Doutorado em Medical Sciences) - University Medical Center Groningen, Abel Tasman talent program; Coorientador: Michel Koole;

Produções bibliográficas

KOOLE, MICHEL ; DEVROME, MARTIJN ; MERTENS, NATHALIE ; SERDONS, KIM ; LACROIX, BRIGITTE ; MERCIER, JOEL ; SCIBERRAS, DAVID ; MAGUIRE, PAUL ; VAN LAERE, KOEN . Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING , v. 46, p. 396-406, 2019.
VIEIRA, IGOR FAGNER ; ORY, DIETER ; CASTEELS, CINDY ; LIMA, FERNANDO R. A. ; VAN LAERE, KOEN ; BORMANS, GUY ; KOOLE, MICHEL . Volume-of-interest-based supervised cluster analysis for pseudo-reference region selection in [18F]DPA-714 PET imaging of the rat brain. EJNMMI Research , v. 8, p. 112, 2018.
DEVROME, MARTIJN ; VAN WEEHAEGHE, DONATIENNE ; DE VOCHT, JOKE ; VAN DAMME, PHILIP ; VAN LAERE, KOEN ; KOOLE, MICHEL . Glucose metabolic brain patterns to discriminate amyotrophic lateral sclerosis from Parkinson plus syndromes. EJNMMI Research , v. 8, p. 110, 2018.
SCHAEVERBEKE, JOLIEN ; EVENEPOEL, CHARLOTTE ; DECLERCQ, LIEVEN ; GABEL, SILVY ; MEERSMANS, KAREN ; BRUFFAERTS, ROSE ; ADAMCZUK, KATE ; DRIES, EVA ; VAN BOUWEL, KAREN ; SIEBEN, ANNE ; PIJNENBURG, YOLANDE ; PEETERS, RONALD ; BORMANS, GUY ; VAN LAERE, KOEN ; KOOLE, MICHEL ; DUPONT, PATRICK ; VANDENBERGHE, RIK . Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING , v. 45, p. 2342-2357, 2018.
SCHAEVERBEKE, JOLIEN ; GABEL, SILVY ; MEERSMANS, KAREN ; BRUFFAERTS, ROSE ; LIUZZI, ANTONIETTA GABRIELLA ; EVENEPOEL, CHARLOTTE ; DRIES, EVA ; VAN BOUWEL, KAREN ; SIEBEN, ANNE ; PIJNENBURG, YOLANDE ; PEETERS, RONALD ; BORMANS, GUY ; VAN LAERE, KOEN ; KOOLE, MICHEL ; DUPONT, PATRICK ; VANDENBERGHE, RIK . Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia. Alzheimers Research & Therapy , v. 10, p. 68, 2018.
CLEEREN, EVY ; CASTEELS, CINDY ; GOFFIN, KAROLIEN ; KOOLE, MICHEL ; VAN LAERE, KOEN ; JANSSEN, PETER ; VAN PAESSCHEN, WIM . Positron emission tomography imaging of cerebral glucose metabolism and type 1 cannabinoid receptor availability during temporal lobe epileptogenesis in the amygdala kindling model in rhesus monkeys. EPILEPSIA , v. 59, p. 959-970, 2018.
LOPES ALVES, ISADORA ; VÁLLEZ GARCÍA, DAVID ; PARENTE, ANDREA ; DOORDUIN, JANINE ; MARQUES DA SILVA, ANA MARIA ; KOOLE, MICHEL ; DIERCKX, RUDI ; WILLEMSEN, ANTOON ; BOELLAARD, RONALD . Correction to: Parametric Imaging of [11C]Flumazenil Binding in the Rat Brain. MOLECULAR IMAGING AND BIOLOGY , v. 20, p. 336-336, 2018.
EBENHAN, THOMAS ; SATHEKGE, MIKE M. ; LENGANA, THABO ; KOOLE, MICHEL ; GHEYSENS, OLIVIER ; GOVENDER, THAVENDRAN ; ZEEVAART, JAN R. . Ga-NOTA-Functionalized Ubiquicidin: Cytotoxicity, Biodistribution, Radiation Dosimetry, and First-in-Human PET/CT Imaging of Infections. JOURNAL OF NUCLEAR MEDICINE , v. 59, p. 334-339, 2018.
BECKERS, LIEN ; ORY, DIETER ; GERIC, IVANA ; DECLERCQ, LIEVEN ; KOOLE, MICHEL ; KASSIOU, MICHAEL ; BORMANS, GUY ; BAES, MYRIAM . Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration. MOLECULAR IMAGING AND BIOLOGY , v. 20, p. 94-102, 2018.
BILLAUD, EMILIE M. F. ; BELDERBOS, SARAH ; CLEEREN, FREDERIK ; MAES, WIM ; VAN DE WOUWER, MARLIES ; KOOLE, MICHEL ; VERBRUGGEN, ALFONS ; HIMMELREICH, UWE ; GEUKENS, NICK ; BORMANS, GUY . Pretargeted PET Imaging Using a Bioorthogonal F-Labeled -Cyclooctene in an Ovarian Carcinoma Model. BIOCONJUGATE CHEMISTRY , v. 28, p. 2915-2920, 2017.
AHAMED, MUNEER ; ATTILI, BALA ; VAN VEGHEL, DAISY ; OOMS, MAARTEN ; BERBEN, PHILIPPE ; CELEN, SOFIE ; KOOLE, MICHEL ; DECLERCQ, LIEVEN ; SAVINAINEN, JUHA R. ; LAITINEN, JARMO T. ; VERBRUGGEN, ALFONS ; BORMANS, GUY . Synthesis and preclinical evaluation of [ 11 C]MA-PB-1 for invivo imaging of brain monoacylglycerol lipase (MAGL). EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , v. 136, p. 104-113, 2017.
KOOLE, MICHEL ; VAN LAERE, KOEN ; AHMAD, RAWAHA ; CECCARINI, JENNY ; BORMANS, GUY ; VANDENBERGHE, WIM . Brain PET imaging of phosphodiesterase 10A in progressive supranuclear palsy and Parkinson's disease. MOVEMENT DISORDERS , v. 32, p. 943-945, 2017.
KHANAPUR, SHIVASHANKAR ; VAN WAARDE, AREN ; DIERCKX, RUDI A.J.O. ; ELSINGA, PHILIP H. ; KOOLE, MICHEL J.B. . Preclinical Evaluation and Quantification of F-Fluoroethyl and F-Fluoropropyl Analogs of SCH442416 as Radioligands for PET Imaging of the Adenosine A Receptor in Rat Brain. JOURNAL OF NUCLEAR MEDICINE , v. 58, p. 466-472, 2017.
ALVES, ISADORA L ; WILLEMSEN, ANTOON TM ; DIERCKX, RUDI A ; DA SILVA, ANA MARIA M ; KOOLE, MICHEL . Dual time-point imaging for post-dose binding potential estimation applied to a [ 11 C]raclopride PET dose occupancy study. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM , v. 37, p. 866-876, 2017.
DECLERCQ, LIEVEN ; ROMBOUTS, FREDERIK ; KOOLE, MICHEL ; FIERENS, KATLEEN ; MARIËN, JONAS ; LANGLOIS, XAVIER ; ANDRÉS, JOSÉ IGNACIO ; SCHMIDT, MARK ; MACDONALD, GREGOR ; MOECHARS, DIEDERIK ; VANDUFFEL, WIM ; TOUSSEYN, THOMAS ; VANDENBERGHE, RIK ; VAN LAERE, KOEN ; VERBRUGGEN, ALFONS ; BORMANS, GUY . Preclinical Evaluation of F-JNJ64349311, a Novel PET Tracer for Tau Imaging. JOURNAL OF NUCLEAR MEDICINE , v. 58, p. 975-981, 2017.
ALVES, ISADORA LOPES ; VÁLLEZ GARCÍA, DAVID ; PARENTE, ANDREA ; DOORDUIN, JANINE ; DIERCKX, RUDI ; MARQUES DA SILVA, ANA MARIA ; KOOLE, MICHEL ; WILLEMSEN, ANTOON ; BOELLAARD, RONALD . Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain. EJNMMI Research , v. 7, p. 17, 2017.
BILLAUD, EMILIE M. F. ; SHAHBAZALI, ELNAZ ; AHAMED, MUNEER ; CLEEREN, FREDERIK ; NOËL, TIMOTHY ; KOOLE, MICHEL ; VERBRUGGEN, ALFONS ; HESSEL, VOLKER ; BORMANS, GUY . Micro-flow photosynthesis of new dienophiles for inverse-electron-demand Diels-Alder reactions. Potential applications for pretargeted in vivo PET imaging. Chemical Science , v. 8, p. 1251-1258, 2017.
STRUYS, TOM ; GOVAERTS, KRISTOF ; OOSTERLINCK, WOUTER ; CASTEELS, CINDY ; BRONCKAERS, ANNELIES ; KOOLE, MICHEL ; VAN LAERE, KOEN ; HERIJGERS, PAUL ; LAMBRICHTS, IVO ; HIMMELREICH, UWE ; DRESSELAERS, TOM . evidence for long-term vascular remodeling resulting from chronic cerebral hypoperfusion in mice. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM , v. 37, p. 726-739, 2017.
TOSSICI-BOLT, LIVIA ; DICKSON, JOHN C. ; SERA, TEREZ ; BOOIJ, JAN ; ASENBAUN-NAN, SUSANNE ; BAGNARA, MARIA C. ; BORGHT, THIERRY VANDER ; JONSSON, CATHRINE ; DE NIJS, ROBIN ; HESSE, SWEN ; KOULIBALY, PIERRE M. ; AKDEMIR, UMIT O. ; KOOLE, MICHEL ; TATSCH, KLAUS ; VARRONE, ANDREA . [123I]FP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods. EJNMMI Physics , v. 4, p. 8, 2017.
VANDENBULCKE, MATHIEU ; BOUCKAERT, FILIP ; DE WINTER, FRANÇOIS-LAURENT ; KOOLE, MICHEL ; ADAMCZUK, KATARZYNA ; VANDENBERGHE, RIK ; EMSELL, LOUISE ; VAN LAERE, KOEN . Asymmetric Amyloid Deposition in the Brain Following Unilateral Electroconvulsive Therapy. BIOLOGICAL PSYCHIATRY , v. 81, p. e11-e13, 2017.
LEURQUIN-STERK, GIL ; CELEN, SOFIE ; VAN LAERE, KOEN ; KOOLE, MICHEL ; BORMANS, GUY ; LANGLOIS, XAVIER ; VAN HECKEN, ANNE ; TE RIELE, PAULA ; ALCÁZAR, JESÚS ; VERBRUGGEN, ALFONS ; DE HOON, JAN ; ANDRÉS, JOSE-IGNACIO ; SCHMIDT, MARK E. . What We Observe In Vivo Is Not Always What We See In Vitro: Development and Validation of C-JNJ-42491293, A Novel Radioligand for mGluR2. JOURNAL OF NUCLEAR MEDICINE , v. 58, p. 110-116, 2017.
LOPES ALVES, ISADORA ; VÁLLEZ GARCÍA, DAVID VÁLLEZ ; PARENTE, ANDREA ; DOORDUIN, JANINE ; DA SILVA, ANA MARIA MARQUES ; KOOLE, MICHEL ; DIERCKX, RUDI ; WILLEMSEN, ANTOON ; BOELLAARD, RONALD . Parametric Imaging of [11C]Flumazenil Binding in the Rat Brain. MOLECULAR IMAGING AND BIOLOGY , v. 20, p. 114-123, 2017.
ALVES, ISADORA L ; MELES, SANNE K ; WILLEMSEN, ANTOON TM ; DIERCKX, RUDI A ; MARQUES DA SILVA, ANA M ; LEENDERS, KLAUS L ; KOOLE, MICHEL . Dual time point method for the quantification of irreversible tracer kinetics: A reference tissue approach applied to [ 18 F]-FDOPA brain PET. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM , v. 37, p. 0271678X1668413, 2016.
OOMS, MAARTEN ; ATTILI, BALA ; CELEN, SOFIE ; KOOLE, MICHEL ; VERBRUGGEN, ALFONS ; VAN LAERE, KOEN ; BORMANS, GUY . [18F]JNJ42259152 binding to phosphodiesterase 10A, a key regulator of medium spiny neuron excitability, is altered in the presence of cyclic AMP. JOURNAL OF NEUROCHEMISTRY , v. 139, p. 897-906, 2016.
ORY, D. ; CELEN, S. ; GIJSBERS, R. ; VAN DEN HAUTE, C. ; POSTNOV, A. ; KOOLE, M. ; VANDEPUTTE, C. ; ANDRES, J.-I. ; ALCAZAR, J. ; DE ANGELIS, M. ; LANGLOIS, X. ; BHATTACHARYA, A. ; SCHMIDT, M. ; LETAVIC, M. A. ; VANDUFFEL, W. ; VAN LAERE, K. ; VERBRUGGEN, A. ; DEBYSER, Z. ; BORMANS, G. . Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates. JOURNAL OF NUCLEAR MEDICINE , v. 57, p. 1436-1441, 2016.
KERNER, GERALD S. M. A. ; KOOLE, MICHEL J. B. ; BONGAERTS, ALPHONS H. H. ; PRUIM, JAN ; GROEN, HARRY J. M. . Total Body Metabolic Tumor Response in ALK Positive Non-Small Cell Lung Cancer Patients Treated with ALK Inhibition. PLoS One , v. 11, p. e0149955, 2016.
LEURQUIN-STERK, GIL ; POSTNOV, ANDREY ; DE LAAT, BART ; CASTEELS, CINDY ; CELEN, SOFIE ; CRUNELLE, CLEO L. ; BORMANS, GUY ; KOOLE, MICHEL ; VAN LAERE, KOEN . Kinetic modeling and long-term test-retest reproducibility of the mGluR5 PET tracer F-FPEB in human brain. SYNAPSE , v. 70, p. 153-162, 2016.
VAN BINNEBEEK, S. ; VANBILLOEN, B. ; BAETE, K. ; TERWINGHE, C. ; KOOLE, M. ; MOTTAGHY, F. M. ; CLEMENT, P. M. ; MORTELMANS, L. ; BOGAERTS, K. ; HAUSTERMANS, K. ; NACKAERTS, K. ; VAN CUTSEM, E. ; VERSLYPE, C. ; VERBRUGGEN, A. ; DEROOSE, C. M. . Comparison of diagnostic accuracy of 111In-pentetreotide SPECT and 68Ga-DOTATOC PET/CT: A lesion-by-lesion analysis in patients with metastatic neuroendocrine tumours. EUROPEAN RADIOLOGY , v. 26, p. 900-909, 2016.
VAN BINNEBEEK, SOFIE ; KOOLE, MICHEL ; TERWINGHE, CHRISTELLE ; BAETE, KRISTOF ; VANBILLOEN, BERT ; HAUSTERMANS, KARINE ; CLEMENT, PAUL ; BOGAERTS, KRIS ; VERBRUGGEN, ALFONS ; NACKAERTS, KRIS ; VAN CUTSEM, ERIC ; VERSLYPE, CHRIS ; MOTTAGHY, FELIX ; DEROOSE, CHRISTOPHE . Dynamic 68Ga-DOTATOC PET/CT and static image in NET patients. NUKLEARMEDIZIN-NUCLEAR MEDICINE , v. 55, p. 104-114, 2016.
ORY, DIETER ; POSTNOV, ANDREY ; KOOLE, MICHEL ; CELEN, SOFIE ; DE LAAT, BART ; VERBRUGGEN, ALFONS ; VAN LAERE, KOEN ; BORMANS, GUY ; CASTEELS, CINDY . Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [18F]DPA-714 PET. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING , v. 43, p. 163-172, 2016.

Projetos de pesquisa

2018 - Atual

Hybrid PET/MRI for improved tumor grading and detection of recurrent/residual disease in Neuro-Oncology, Descrição: The aim of this project is to take advantage of hybrid PET/MRI for simultaneous imaging of brain tumour metabolism using PET and tumour angiogenesis and morphology using MRI. In a first stage, an automated analysis of dynamic amino acid PET data to provide the end user with an objective and accurate metabolic profile of the primary tumour or potential local recurrences will be developed. Next, a multi-parametric approach combining this metabolic profile with structural and perfusion MRI will be evaluated for improved tumour grading and enhanced therapy response prediction, evaluated by clinical follow-up and post therapy PET/MRI scanning. This approach will involve the evaluation and further development of multi-parametric segmentation and classification techniques for brain tumour lesions.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Michel Koole - Coordenador / Karolien Goffin - Integrante / Masoomeh Rahimpour - Integrante.
2017 - Atual

Multimodal view on brain connectivity with simultaneous PET/MR, Descrição: The objective is to combine structural (SC) and functional (FC) connectivity information derived from multiparametric MR data with the simultaneous acquired metabolic connectivity (MC) information from PET. A graph approach is intended, representing the brain as a network constituted by nodes (parcellated brain regions) and edges expressing the connection strength between the nodes. Deeper understanding of disease progression will be obtained by investigating how network parameters change over time.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Michel Koole - Coordenador / Koenraad Van Laere - Integrante / Martijn Devrome - Integrante.

Prêmios

2009

Rotblat medal, Physics in Medicine and Biology.

2001

Dombal Student prize, European Society for Engineering and Medicine.

Histórico profissional

Endereço profissional

Katholieke Universiteit Leuven. , Herestraat 49, Leuven, 3000 - Leuven, - Bélgica, Telefone: (32) 16341242

Experiência profissional

2014 - Atual

Katholieke Universiteit Leuven, KU Leuven

Vínculo: Civil servant, Enquadramento Funcional: Associate Professor, Regime: Dedicação exclusiva.

Atividades

01/2014
Pesquisa e desenvolvimento, Nuclear Medicine and Molecular Imaging.,Linhas de pesquisa
01/2014
Conselhos, Comissões e Consultoria, Faculty of Medicine.,Cargo ou função, Member (as senior academic staff) of the Council of the Faculty of Medicine.
01/2014
Conselhos, Comissões e Consultoria, Department of Imaging & Pathology.,Cargo ou função, Member (as senior academic staff) of the Council of the Department of Imaging & Pathology.

2012 - 2014

University Medical Center Groningen

Vínculo: Formal labor contract, Enquadramento Funcional: Medical Radiation Physicist, Regime: Dedicação exclusiva.

Atividades

01/2012 - 01/2014
Pesquisa e desenvolvimento, Nuclear Medicine and Molecular Imaging department.,Linhas de pesquisa