Bruno Alvim Chrisostomo

Formação complementar

Idiomas

Áreas de atuação

Produções bibliográficas

• GONZAGA, VIRGÍNIA DE ALENCAR MUNIZ ; CHRISOSTOMO, BRUNO ALVIM ; POLI, ALESSANDRA LIMA ; SCHMITT, CARLA CRISTINA . Preparation, Characterization and Photostability of Nanocomposite Films Based on Poly(acrylic acid) and Montmorillonite. MATERIALS RESEARCH , v. 21, p. 1, 2018.

• SHATRUK, MICHAEL ; PHAN, HOA ; CHRISOSTOMO, BRUNO A. ; SULEIMENOVA, AKMARAL . Symmetry-breaking structural phase transitions in spin crossover complexes. COORDINATION CHEMISTRY REVIEWS , v. 289, p. 62-73, 2015.

• BA Chrisostomo ; Mori RC . Estudo de caso: Férias Mer-curiosas. In: Salete Linhares Queiroz; Carolina Sotério. (Org.). Estudos de caso: abordagem para o ensino de química. 1ed.São Carlos, SP: Diagrama Editorial, 2023, v. , p. 16-27.

• BA Chrisostomo . Considerations on the nature of scientific knowledge and literature. 2022. (Apresentação de Trabalho/Seminário).

• BA Chrisostomo ; KASSEBOEHMER, A. C. . Integrating the Cognitive Acceleration through Science Education (CASE) Method for teaching with The Big 5 Model of Personality for the classroom context. 2022. (Apresentação de Trabalho/Comunicação).

• BA Chrisostomo . Molecular Design, Synthesis and Trypanocidal Activity of Cysteine Protease Reversible Covalent Inhibitors: On the Selectivity of Cruzain and Cathepsin L. 2018. (Apresentação de Trabalho/Seminário).

Outras produções

Projetos de pesquisa

• 2021 - Atual

  Investigation of Soil Organic Matter and Sediment Organic Matter of Nhecolândia, Sub-Region in the Brazilian Pantanal, Descrição: This project is a constituent (Research Action 2: Genesis and Dynamics of the Soil-Lakes System of Pantanal) of Thematic Project 2016/14227-5 (FAPESP) which presents the following main activities, contextualized for the Nhecolândia sub-region, Brazilian Pantanal: (1) measurement of greenhouse gas (GHG) emissions in established time periods; (2) verification of the role of the soil in the genesis and (3) in the general dynamics of the lakes; (4) mapping microbial diversity in waters of the lakes and (5) monitoring chemical composition in relation to it; (6) geochronological dating of the minerals in the sediments and in the soil; (7) use of isotopic signatures of clay minerals as indicators of the properties of parental waters; (8) verification of the lake sensitivities to external perturbations, e.g. climate change; (9) evaluation of the potential of remote sensing data for characterization of the different lakes; and (10) extrapolation of the greenhouse gas emission data to the entire area of Nhecolândia, beyond the local pilot study area. Having the stated Thematic Project as background, this project is defined as the study of soil organic matter (SOM) and sediments of Nhecolândia. Expected data is applicable to the understanding of the bio-geo-chemical functioning of the lakes (carbon, nitrogen and arsenic dependent environmental processes) and to the fluxes of greenhouse gases. This end will be accomplished implementing analytical techniques: Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) Spectroscopy, Fluorescence Spectroscopy (Excitation, Emission, Synchronized, Excitation-Emission Matrices (EEMs), Time-Resolved Fluorescence Spectroscopy and Laser-Induced Fluorescence Spectroscopy (LIF)). Results will be analyzed by Parallel Factor Analysis (PARAFAC).. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Bruno Alvim Chrisostomo - Integrante / Débora Marcondes Bastos Pereira - Coordenador.

• 2018 - 2019

  Molecular Design, Synthesis and Trypanocidal Activity of Cysteine Protease Reversible Covalent Inhibitors: On the Selectivity of Cruzain and Cathepsin L, Descrição: Cysteine proteases (CPs) are important therapeutic targets in a range of human diseases, including Chagas disease (cruzain), Leishmaniasis (CPs) and various cancers (cathepsins). We have an established research program for developing CP reversible covalent inhibitors as novel trypanocidal agents. This program has recently identified a series of new potent chemical entities against cruzain, cysteine protease B of Leishmania mexicana (LmCPB) and human cathepsin L (hCATL). Neq0593 and Neq0594 are better than one of the only two approved drugs for Chagas disease. Moreover, we have also discovered that other cruzain inhibitors also inhibit cathepsin L (hCatL), a promising target for the prevention of metastasis in various cancers. Notwithstanding these are promising leads, there is considerable room for optimisation, as well as for new chemotypes. In this project, we propose to combine our knowledge and expertise in CP reversible covalent inhibition with novel computational methods for hypothesis driven molecular design for the discovery of new reversible covalent inhibitors of cruzain and hCatL. We will focus on compounds containing an activated nitrile, an electrophile that is able to form a reversible covalent bond with the catalytic cysteine in the protease active site. The reversibility can alleviate the possibility of "off-target" binding that are present in most irreversible covalent inhibitors. We will design new libraries of nitriles, as well as focused libraries based on our inhibitors. We will computationally screen these libraries to select putative candidates designed for improved potency and specificity using our new state-of-the-art machine learning tools. The compounds will be synthesized, assessed experimentally in vitro and in cell based assays, possibly leading to the first selective reversible covalent inhibitors for the two aforementioned CPs.. , Situação: Desativado; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Bruno Alvim Chrisostomo - Integrante / Carlos Alberto Montanari - Coordenador., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Bolsa.

• 2015 - 2016

  Symmetry-breaking structural phase transitions in spin crossover complexes, Descrição: We review spin-crossover (SCO) complexes of 3d transition metal ions that exhibit structural phase transitions (SPTs) associated with changes in the space group symmetry. An analysis of the existing cases extracted by data-mining the Cambridge Structural Database reveals that they can be classified according to the particular cause of symmetry breaking. One class of complexes exhibits the SPT caused by concerted displacive atomic motions due to the change in the metal-ligand bond lengths during the SCO. Such transitions are usually abrupt, with strong coupling between the SCO and SPT. The second class is characterized by symmetry lowering due to the stabilization of an intermediate mixed high-spin/low-spin state. The abruptness of the SCO is not a necessity in such case. Finally, in the third class, the SPT takes place due to the crystallographic ordering of peripheral groups, counter ions, or solvent molecules that are remote from the SCO centers. Such SPTs exhibit only weak coupling (if any) to the SCO. This analysis is expected to assist in the design of multifunctional SCO materials that rely on the symmetry-breaking SPTs.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Mestrado acadêmico: (1) / Doutorado: (1) . , Integrantes: Bruno Alvim Chrisostomo - Integrante / SHATRUK, MICHAEL - Coordenador / PHAN, HOA - Integrante / SULEIMENOVA, AKMARAL - Integrante., Número de produções C, T & A: 1

• 2014 - 2015

  Preparation, Characterization and Photostability of Nanocomposite Films Based on Poly(acrylic acid) and Montmorillonite, Descrição: Polyacrylic acid (PAA)/clay mineral (SWy-1) nanocomposites were prepared by intercalation in solution and their photostability was evaluated. For the nanocomposite films containing 5, 10 and 20 wt % in SWy-1 mass occurred intercalation along with some clay exfoliation, while for PAA/30%SWy-1, the intercalation of PAA chains into the clay interlayers was observed. Scanning Electron Microscopy (SEM) images of the films suggested that nanocomposite films are homogeneous, indicating efficient dispersion of the polymer matrix into the SWy-1 clay. The thermal degradation temperatures of depolymerisation for the nanocomposite films were higher (362-370 °C) than pure PAA (361 °C), which means that the presence of SWy-1 clay promotes thermal stabilization.The photooxidative degradation of pure PAA and nanocomposite films was followed using Size Exclusion Chromatography (SEC). The degradation rate constant for pure PAA was higher than nanocomposite films; therefore, the increase of SWy-1concentration detained the degradation of PAA. The presence of SWy-1 clay contributes for the photostabilization of the material. SWy-1 has ability to disperse the incident light as well as also to absorb part of the UV light instead of PAA, hence minimizing the degradation rate.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Bruno Alvim Chrisostomo - Integrante / Carla Cristina Schmitt Cavalheiro - Coordenador., Número de produções C, T & A: 1

• 2012 - 2013

  Natural polysaccharide hydrolysis by terrestrial and aquatic microorganism, Descrição: Investigation of cellulolysis via enzymatic cellulase reaction involving a variety of microorganisms.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Bruno Alvim Chrisostomo - Coordenador / Andre Luiz Meleiro Porto - Integrante.

Prêmios